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3D biocompatibility

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https://www.readbyqxmd.com/read/28208019/cyanographene-and-graphene-acid-emerging-derivatives-enabling-high-yield-and-selective-functionalization-of-graphene
#1
Aristides Bakandritsos, Martin Pykal, Piotr Blonski, Petr Jakubec, Demetrios D Chronopoulos, Katerina Polakova, Vasilios Georgakilas, Klára Čépe, Ondrej Tomanec, Vaclav Ranc, Athanasios B Bourlinos, Radek Zboril, Michal Otyepka
Efficient and selective methods for covalent derivatization of graphene are needed because they enable tuning of graphene's surface and electronic properties, thus expanding its application potential. However, existing approaches based mainly on chemistry of graphene and graphene oxide achieve only limited level of functionalization due to chemical inertness of the surface and non-selective simultaneous attachment of different functional groups, respectively. Here we present a conceptually different route based on synthesis of cyanographene via the controllable substitution and defluorination of fluorographene...
February 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28191927/foldectures-3d-molecular-architectures-from-self-assembly-of-peptide-foldamers
#2
Sung Hyun Yoo, Hee-Seung Lee
The wide range of fascinating supramolecular architectures found in nature, from DNA double helices to giant protein shells, inspires researchers to mimic the diverse shapes and functions of natural systems. Thus, a variety of artificial molecular platforms have been developed by assembling DNA-, peptide-, and protein-based building blocks for medicinal and biological applications. There has also been a significant interest in the research of non-natural oligomers (i.e., foldamers) that fold into well-defined secondary structures analogous to those found in proteins, because the assemblies of foldamers are expected not only to form biomimetic supramolecular architectures that resemble those of nature but also to display unique functions and unprecedented topologies at the same time due to their different folding propensities from those of natural building blocks...
February 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28187519/development-of-a-novel-alginate-polyvinyl-alcohol-hydroxyapatite-hydrogel-for-3d-bioprinting-bone-tissue-engineered-scaffolds
#3
Stephanie T Bendtsen, Sean P Quinnell, Mei Wei
3D printed biomaterials used as personalized tissue substitutes have the ability to promote and enhance regeneration in areas of defected tissue. The challenge with 3D printing for bone tissue engineering remains the selection of a material with optimal rheological properties for printing in addition to biocompatibility and capacity for uniform cell incorporation. Hydrogel biomaterials may provide sufficient printability to allow cell encapsulation and bioprinting of scaffolds with uniform cell distribution...
February 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28185928/biologically-active-and-biomimetic-dual-gelatin-scaffolds-for-tissue-engineering
#4
P Sánchez, J L Pedraz, G Orive
We have designed, developed and optimized Genipin cross-linked 3D gelatin scaffolds that were biologically active and biomimetic, show a dual activity both for growth factor and cell delivery. Type B gelatin powder was dissolved in DI water. 100mg of genipin was dissolved in 10ml of DI water. Three genipin concentrations were prepared: 0.1%, 0.2% and 0.3% (w/v). Solutions were mixed at 40°C and under stirring and then left crosslinking for 72h. Scaffolds were obtained by punching 8 mm-cylinders into ethanol 70% solution for 10min and then freeze-drying...
February 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28183670/influence-of-different-grained-powders-and-pellets-made-of-niobium-and-ti-42nb-on-human-cell-viability
#5
Jana Markhoff, Markus Weinmann, Christian Schulze, Rainer Bader
Nowadays, biomaterials can be used to maintain or replace several functions of the human body if necessary. Titanium and its alloys, i.e. Ti6Al4V are the most common materials (70 to 80%) used for structural orthopedic implants due to their unique combination of good mechanical properties, corrosion resistance and biocompatibility. Addition of β-stabilizers, e.g. niobium, can improve the mechanical properties of such titanium alloys further, simultaneously offering excellent biocompatibility. In this in vitro study, human osteoblasts and fibroblasts were cultured on different niobium specimens (Nb Amperit, Nb Ampertec), Nb sheets and Ti-42Nb (sintered and 3D-printed by selective laser melting, SLM) and compared with forged Ti6Al4V specimens...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28165099/3d-printing-of-concentrated-emulsions-into-multiphase-biocompatible-soft-materials
#6
Marianne R Sommer, Lauriane Alison, Clara Minas, Elena Tervoort, Patrick A Rühs, André R Studart
3D printing via direct ink writing (DIW) is a versatile additive manufacturing approach applicable to a variety of materials ranging from ceramics over composites to hydrogels. Due to the mild processing conditions compared to other additive manufacturing methods, DIW enables the incorporation of sensitive compounds such as proteins or drugs into the printed structure. Although emulsified oil-in-water systems are commonly used vehicles for such compounds in biomedical, pharmaceutical, and cosmetic applications, printing of such emulsions into architectured soft materials has not been fully exploited and would open new possibilities for the controlled delivery of sensitive compounds...
February 6, 2017: Soft Matter
https://www.readbyqxmd.com/read/28150412/new-application-of-three-dimensional-printing-biomaterial-in-nasal-reconstruction
#7
Sun Hwa Park, Byeong Gon Yun, Joo Yun Won, Won Soo Yun, Jin Hyung Shim, Mi Hyun Lim, Do Hyun Kim, Sang A Baek, Yahya Dhafer Alahmari, Jun Ho Jeun, Se Hwan Hwang, Sung Won Kim
OBJECTIVES: Polycaprolactone (PCL) is an U.S. Food and Drug Administration-approved synthetic biodegradable polymer and is easily fabricated into three-dimensional (3D) structures. In this study, the 3D-printed PCL implant for nasal augmentation was further evaluated for its suitability for nasal surgeries such as septoplasty and rhinoplasty. METHODS: Ten New Zealand White rabbits were included and divided into study and sham groups (7 and 3, respectively). A lateral incision was made on the nasal dorsum and a pocket formed in the subperichondrial plane between the upper lateral cartilage and nasal septum...
February 1, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28140524/micropatterning-of-reagent-free-high-energy-crosslinked-gelatin-hydrogels-for-bioapplications
#8
Benedikt Heyart, Astrid Weidt, Emilia I Wisotzki, Mareike Zink, Stefan G Mayr
Hydrogels are crosslinked polymeric gels of great interest in the field of tissue engineering, particularly as biocompatible cell or drug carriers. Reagent-free electron irradiated gelatin is simple to manufacture, inexpensive and biocompatible. Here, the potential to micropattern gelatin hydrogel surfaces during electron irradiation crosslinking was demonstrated as a promising microfabrication technique to produce thermally stable structures on highly relevant length scales for bioapplications. In the present work, grooves of 3...
January 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28135637/fabrication-and-characterization-of-baghdadite-nanostructured-scaffolds-by-space-holder-method
#9
Sorour Sadeghzade, Fateme Shamoradi, Rahmatollah Emadi, Fariborz Tavangarian
Porous baghdadite scaffold has received great attention as a candidate for bone tissue engineering application due to its remarkable bioactivity, biocompatibility, and good bone formation ability. A few studies have been focused on improving the mechanical properties of baghdadite scaffolds. Recently, space holder method has been introduced as a new and viable technique to prepare bioceramic scaffolds with interconnected pores and suitable mechanical properties. In this study, for the first time, 3D baghdadite scaffolds with interconnected porosity were produced using space holder method...
January 24, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28129145/a-biocompatible-near-infrared-3d-tracking-system
#10
Ryan Decker, Azad Shademan, Justin Opfermann, Simon Leonard, Peter Kim, Axel Krieger
A fundamental challenge in soft-tissue surgery is that target tissue moves and deforms, becomes occluded by blood or other tissue, and is difficult to differentiate from surrounding tissue. We developed small biocompatible near-infrared fluorescent (NIRF) markers with a novel fused plenoptic and NIR camera tracking system, enabling 3D tracking of tools and target tissue while overcoming blood and tissue occlusion in the uncontrolled, rapidly changing surgical environment. In this work, we present the tracking system and marker design and compare tracking accuracies to standard optical tracking methods using robotic experiments...
January 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28123295/platelet-functionalized-three-dimensional-poly-%C3%AE%C2%B5-caprolactone-fibrous-scaffold-prepared-using-centrifugal-spinning-for-delivery-of-growth-factors
#11
Michala Rampichová, Matej Buzgo, Andrea Míčková, Karolína Vocetková, Věra Sovková, Věra Lukášová, Eva Filová, Franco Rustichelli, Evžen Amler
Bone and cartilage are tissues of a three-dimensional (3D) nature. Therefore, scaffolds for their regeneration should support cell infiltration and growth in all 3 dimensions. To fulfill such a requirement, the materials should possess large, open pores. Centrifugal spinning is a simple method for producing 3D fibrous scaffolds with large and interconnected pores. However, the process of bone regeneration is rather complex and requires additional stimulation by active molecules. In the current study, we introduced a simple composite scaffold based on platelet adhesion to poly-ε-caprolactone 3D fibers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28120511/collagen-heparin-sulfate-scaffolds-fabricated-by-a-3d-bioprinter-improved-mechanical-properties-and-neurological-function-after-spinal-cord-injury-in-rats
#12
Chong Chen, Ming-Liang Zhao, Ren-Kun Zhang, Gang Lu, Chang-Yu Zhao, Feng Fu, Hong-Tao Sun, Sai Zhang, Yue Tu, Xiao-Hong Li
Effective treatments promoting axonal regeneration and functional recovery for spinal cord injury (SCI) are still in the early stages of development. Most approaches have been focused on providing supportive substrates for guiding neurons and overcoming the physical and chemical barriers to healing that arise after SCI. Although collagen has become a promising natural substrate with good compatibility, its low mechanical properties restrict its potential applications. The mechanical properties mainly rely on the composition and pore structure of scaffolds...
January 25, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28113546/magnetic-particle-imaging-a-resovist-based-marking-technology-for-guide-wires-and-catheters-for-vascular-interventions
#13
Julian Haegele, Sjef Cremers, Jurgen Rahmer, Jochen Franke, Sarah Vaalma, Michael Heidenreich, Joern Borgert, Paul Borm, Joerg Barkhausen, Florian Vogt
Magnetic Particle Imaging (MPI) is able to provide high temporal and good spatial resolution, high signal to noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs), over a wide range practically relevant concentrations. Thus, MPI is proposed as a promising future method for guidance of vascular interventions. To implement this, devices such as guide wires and catheters have to be discernible in MPI, which can be achieved by coating already commercially available devices with SPIOs...
April 27, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28113330/towards-retrieving-force-feedback-in-robotic-assisted-surgery-a-supervised-neuro-recurrent-vision-approach
#14
Angelica I Aviles Rivero, Samar M Alsaleh, James K Hahn, Alicia Casals
Robotic-assisted minimally invasive surgeries have gained a lot of popularity over conventional procedures as they offer many benefits to both surgeons and patients. Nonetheless, they still suffer from some limitations that affect their outcome. One of them is the lack of force feedback which restricts the surgeon's sense of touch and might reduce precision during a procedure. To overcome this limitation, we propose a novel force estimation approach that combines a vision based solution with supervised learning to estimate the applied force and provide the surgeon with a suitable representation of it...
December 15, 2016: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28112836/amino-acids-and-peptide-based-supramolecular-hydrogels-for-three-dimensional-cell-culture
#15
REVIEW
Xiao-Qiu Dou, Chuan-Liang Feng
Supramolecular hydrogels assembled from amino acids and peptide-derived hydrogelators have shown great potential as biomimetic three-dimensional (3D) extracellular matrices because of their merits over conventional polymeric hydrogels, such as non-covalent or physical interactions, controllable self-assembly, and biocompatibility. These merits enable hydrogels to be made not only by using external stimuli, but also under physiological conditions by rationally designing gelator structures, as well as in situ encapsulation of cells into hydrogels for 3D culture...
January 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28112762/3d-printable-conducting-hydrogels-containing-chemically-converted-graphene
#16
Sepidar Sayyar, Sanjeev Gambhir, Johnson Chung, David L Officer, Gordon G Wallace
The development of conducting 3D structured biocompatible scaffolds for the growth of electroresponsive cells is critical in the field of tissue engineering. This work reports the synthesis and 3D processing of UV-crosslinkable conducting cytocompatible hydrogels that are prepared from methacrylated chitosan (ChiMA) containing graphenic nanosheets. The addition of chemically converted graphene resulted in mechanical and electrical properties of the composite that were significantly better than ChiMA itself, as well as improved adhesion, proliferation and spreading of L929 fibroblasts cells...
January 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28106378/cell-selective-apoptosis-induced-by-polymorphic-alteration-of-self-assembled-silica-nano-webs
#17
Meysam Keshavarz, Bo Tan, Krishnan Venkatakrishnan
The biocompatibility of silicon-based nanomaterial makes it suitable for biophysical and biomedical applications. However, the application of silicon-based nanomaterials has been mainly restricted to nanoparticles (NPs) as a potential drug carrier and the extracellular matrix (ECM) as a platform for cell adhesion and proliferation. Here, we introduced silica NPs self-assembled into a 3D nano-web architecture that was shown to inherit the therapeutic and proliferative attributes of both NPs and ECMs. The self-assembled silica nano-web (SNW) has, therefore, not only shown targeted drug-like behavior in HeLa cells without the use of bio-markers but also has shown ECM characteristics...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28095322/competent-processing-techniques-for-scaffolds-in-tissue-engineering
#18
REVIEW
Ranjna C Dutta, Madhuri Dey, Aroop K Dutta, Bikramjit Basu
Engineering a functional tissue ex vivo requires a synchronized effort towards developing technologies for ECM mimicking scaffold and cultivating tissue-specific cells in an integrated and controlled manner. Cell-interactive scaffolds in three dimensions (3D), designed and processed appropriately with an apt biomaterial to yield optimal porosity and mechanical strength is the key in tissue engineering (TE). In order to accomplish these facets in a 3D scaffold, multiple techniques and processes have been explored by researchers all over the world...
January 14, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28093365/vitamin-b3-metal-organic-frameworks-as-potential-delivery-vehicles-for-therapeutic-nitric-oxide
#19
Rosana V Pinto, Fernando Antunes, João Pires, Vanessa Graça, Paula Brandão, Moisés L Pinto
: The synthesis and structural characterization of two isostructural metal (M=Ni, Co) 3D framework structure that integrate vitamin B3 building blocks with NO delivery capabilities and low toxicity is presented. The compounds with a formula [M2(μ2-H2O)(μ-vitamin B3)4]·2H2O contain two crystallographic distinct divalent metal centers connected by a bridging water and carboxylate group from vitamin B3. The porous compounds have the capability of storing and releasing nitric oxide (NO) in a slow and reversible manner, with released amounts of 2...
January 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28093363/alignment-of-collagen-fiber-in-knitted-silk-scaffold-for-functional-massive-rotator-cuff-repair
#20
Zefeng Zheng, Jisheng Ran, Weishan Chen, Yejun Hu, Ting Zhu, Xiao Chen, Zi Yin, Boon Chin Heng, Gang Feng, Huihui Le, Chenqi Tang, Jiayun Huang, Yangwu Chen, Yiting Zhou, Pioletti Dominique, Weiliang Shen, Hong-Wei Ouyang
: Rotator cuff tear is one of the most common types of shoulder injuries, often resulting in pain and physical debilitation. Allogeneic tendon-derived decellularized matrices do not have appropriate pore size and porosity to facilitate cell infiltration, while commercially-available synthetic scaffolds are often inadequate at inducing tenogenic differentiation. The aim of this study is to develop an advanced 3D aligned collagen/silk scaffold (ACS) and investigate its efficacy in a rabbit massive rotator cuff tear model...
January 13, 2017: Acta Biomaterialia
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