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3D biocompatibility

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https://www.readbyqxmd.com/read/27925441/anodized-3d-printed-titanium-implants-with-dual-micro-and-nano-scale-topography-promote-interaction-with-human-osteoblasts-and-osteocyte-like-cells
#1
Karan Gulati, Matthew Prideaux, Masakazu Kogawa, Luis Lima-Marques, Gerald J Atkins, David M Findlay, Dusan Losic
The success of implantation of materials into bone is governed by effective osseointegration, requiring biocompatibility of the material and the attachment and differentiation of osteoblastic cells. To enhance cellular function in response to the implant surface, micro- and nano-scale topography have been suggested as essential. In this study, we present bone implants based on 3D-printed titanium alloy (Ti6Al4V), with a unique dual topography composed of micron-sized spherical particles and vertically aligned titania nanotubes...
December 7, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27919840/development-fabrication-and-evaluation-of-a-novel-biomimetic-human-breast-tissue-derived-breast-implant-surface
#2
S Barr, E W Hill, A Bayat
: Breast implant use has tripled in the last decade with over 320,000 breast implant based reconstructions and augmentations performed in the US per annum. Unfortunately a considerable number of women will experience capsular contracture, the irrepressible and disfiguring, tightening and hardening of the fibrous capsule that envelops the implant. Functionalising implant surfaces with biocompatible tissue-specific textures may improve in-vivo performance. A novel biomimetic breast implant is presented here with anti-inflammatory in-vitro abilities...
December 2, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27918540/in-vivo-quantification-of-spatially-varying-mechanical-properties-in-developing-tissues
#3
Friedhelm Serwane, Alessandro Mongera, Payam Rowghanian, David A Kealhofer, Adam A Lucio, Zachary M Hockenbery, Otger Campàs
The mechanical properties of the cellular microenvironment and their spatiotemporal variations are thought to play a central role in sculpting embryonic tissues, maintaining organ architecture and controlling cell behavior, including cell differentiation. However, no direct in vivo and in situ measurement of mechanical properties within developing 3D tissues and organs has yet been performed. Here we introduce a technique that employs biocompatible, magnetically responsive ferrofluid microdroplets as local mechanical actuators and allows quantitative spatiotemporal measurements of mechanical properties in vivo...
December 5, 2016: Nature Methods
https://www.readbyqxmd.com/read/27901555/osteoblast-seeded-bioglass-gelatin-nanocomposite-a-promising-bone-substitute-in-critical-size-calvarial-defect-repair-in-rat
#4
Behrooz Johari, Mehdi Kadivar, Shirin Lak, Mazaher Gholipourmalekabadi, Aleksandra M Urbanska, Masoud Mozafari, Maryam Ahmadzadehzarajabad, Asaad Azarnezhad, Samane Afshari, Jamil Zargan, Saeid Kargozar
INTRODUCTION: Amid the plethora of methods to repair critical bone defects, there is no one perfect approach. In this study, we sought to evaluate a potent 3-dimensional (3D) bioactive SiO2-CaO-P2O5 glasses (bioglass)/gelatin (gel) scaffold for its biocompatibility by seeding cells as well as for its regenerative properties by animal implantation. METHODS: Osteoblast cells were seeded onto nanocomposite scaffolds to investigate the process of critical-size calvarial defect via new bone formation...
November 29, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27877865/three-dimensional-printed-macroporous-polylactic-acid-hydroxyapatite-composite-scaffolds-for-promoting-bone-formation-in-a-critical-size-rat-calvarial-defect-model
#5
Haifeng Zhang, Xiyuan Mao, Zijing Du, Wenbo Jiang, Xiuguo Han, Danyang Zhao, Dong Han, Qingfeng Li
We have explored the applicability of printed scaffold by comparing osteogenic ability and biodegradation property of three resorbable biomaterials. A polylactic acid/hydroxyapatite (PLA/HA) composite with a pore size of 500 μm and 60% porosity was fabricated by three-dimensional printing. Three-dimensional printed PLA/HA, β-tricalcium phosphate (β-TCP) and partially demineralized bone matrix (DBM) seeded with bone marrow stromal cells (BMSCs) were evaluated by cell adhesion, proliferation, alkaline phosphatase activity and osteogenic gene expression of osteopontin (OPN) and collagen type I (COL-1)...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27875939/injectable-shape-memorizing-3d-hyaluronic-acid-cryogels-3d-ma-ha-for-skin-sculpting-and-soft-tissue-reconstruction
#6
Liying Cheng, Kai Ji, Ting-Yu Shih, Anthony Haddad, Giorgio Giatsidis, David J Mooney, Dennis P Orgill, Christoph S Nabzdyk
Introduction Hyaluronic acid based (HA) fillers are used for various cosmetic procedures. However, due to filler migration and degradation, reinjections of the fillers are often required. Methacrylated HA (MA-HA) can be made into injectable, shape-memorizing fillers (3D MA-HA) aimed to address this issue. In this study shape retention, firmness and biocompatibility of 3D MA-HA injected subcutaneously in mice were evaluated. Methods Fifteen mice, each receiving two subcutaneous injections in their back, were divided into 4 groups receiving HA, MA-HA, 3D MA-HA or saline, respectively...
November 22, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27872844/fabrication-of-poly-%C3%AE%C2%B5-caprolactone-scaffolds-reinforced-with-cellulose-nanofibers-with-and-without-the-addition-of-hydroxyapatite-nanoparticles
#7
Pedro Morouço, Sara Biscaia, Tânia Viana, Margarida Franco, Cândida Malça, Artur Mateus, Carla Moura, Frederico C Ferreira, Geoffrey Mitchell, Nuno M Alves
Biomaterial properties and controlled architecture of scaffolds are essential features to provide an adequate biological and mechanical support for tissue regeneration, mimicking the ingrowth tissues. In this study, a bioextrusion system was used to produce 3D biodegradable scaffolds with controlled architecture, comprising three types of constructs: (i) poly(ε-caprolactone) (PCL) matrix as reference; (ii) PCL-based matrix reinforced with cellulose nanofibers (CNF); and (iii) PCL-based matrix reinforced with CNF and hydroxyapatite nanoparticles (HANP)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27865067/laminin-modified-and-aligned-phbv-peo-nanofibrous-nerve-conduits-promote-peripheral-nerve-regeneration
#8
Xiao-Feng Zhang, Hai-Xia Liu, Lazarus Santiago Ortiz, Zhong-Dang Xiao, Ning-Ping Huang
Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has received much attention for its biodegradability and biocompatibility, characteristics which are required in tissue engineering. In this study, polyethylene oxide (PEO)-incorporated PHBV nanofibers with random or aligned orientation were obtained by electrospinning. For further use in vivo, the nanofiber films were made into nerve conduits after treated with NH3 plasma, which could improve the hydrophilicity of inner surfaces of nerve conduits and then facilitate laminin adsorption via electrostatic interaction for promoting cell adhesion and proliferation...
November 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27865007/anisotropic-materials-for-skeletal-muscle-tissue-engineering
#9
Soumen Jana, Sheeny K Lan Levengood, Miqin Zhang
Repair of damaged skeletal-muscle tissue is limited by the regenerative capacity of the native tissue. Current clinical approaches are not optimal for the treatment of large volumetric skeletal-muscle loss. As an alternative, tissue engineering represents a promising approach for the functional restoration of damaged muscle tissue. A typical tissue-engineering process involves the design and fabrication of a scaffold that closely mimics the native skeletal-muscle extracellular matrix (ECM), allowing organization of cells into a physiologically relevant 3D architecture...
November 16, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27858378/label-free-3d-ag-nanoflower-based-electrochemical-immunosensor-for-the-detection-of-escherichia-coli-o157-h7-pathogens
#10
He Huang, Minghuan Liu, Xiangsheng Wang, Wenjie Zhang, Da-Peng Yang, Lianhua Cui, Xiansong Wang
It is highly desirable to develop a rapid and simple method to detect pathogens. Combining nanomaterials with electrochemical techniques is an efficient way for pathogen detection. Herein, a novel 3D Ag nanoflower was prepared via a biomineralization method by using bovine serum albumin (BSA) as a template. It was adopted as a sensing interface to construct an electrochemical bacteria immunosensor for the rapid detection of foodborne pathogens Escherichia coli (E. coli) O157:H7. Bacterial antibody was immobilized onto the surface of Ag nanoflowers through covalent conjugation...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27857076/3d-visualization-of-additive-occlusion-and-tunable-full-spectrum-fluorescence-in-calcite
#11
David C Green, Johannes Ihli, Paul D Thornton, Mark A Holden, Bartosz Marzec, Yi-Yeoun Kim, Alex N Kulak, Mark A Levenstein, Chiu Tang, Christophe Lynch, Stephen E D Webb, Christopher J Tynan, Fiona C Meldrum
From biomineralization to synthesis, organic additives provide an effective means of controlling crystallization processes. There is growing evidence that these additives are often occluded within the crystal lattice. This promises an elegant means of creating nanocomposites and tuning physical properties. Here we use the incorporation of sulfonated fluorescent dyes to gain new understanding of additive occlusion in calcite (CaCO3), and to link morphological changes to occlusion mechanisms. We demonstrate that these additives are incorporated within specific zones, as defined by the growth conditions, and show how occlusion can govern changes in crystal shape...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27845276/3d-scaffold-with-effective-multidrug-sequential-release-against-bacteria-biofilm
#12
Rafaela García-Alvarez, Isabel Izquierdo-Barba, María Vallet-Regí
Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous regeneration and local multidrug therapy so as to avoid bacterial growth, drug resistance and the feared side effects. Herein, hierarchical 3D multidrug scaffolds based on nanocomposite bioceramic and polyvinyl alcohol (PVA) prepared by rapid prototyping with an external coating of gelatin-glutaraldehyde (Gel-Glu) have been fabricated...
November 11, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27834642/magnetic-particle-imaging-a-resovist-based-marking-technology-for-guide-wires-and-catheters-for-vascular-interventions
#13
Julian Haegele, Nikolaos Panagiotopoulos, Sjef Cremers, Ju Rgen Rahmer, Jochen Franke, Robert L Duschka, Sarah Vaalma, Michael Heidenreich, Jo Rn Borgert, Paul Borm, Jo Rg Barkhausen, Florian M Vogt
Magnetic particle imaging (MPI) is able to provide high temporal and good spatial resolution, high signal to noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs), over a wide range practically relevant concentrations. Thus, MPI is proposed as a promising future method for guidance of vascular interventions. To implement this, devices such as guide wires and catheters have to be discernible in MPI, which can be achieved by coating already commercially available devices with SPIOs...
October 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27830490/soft-3d-printed-phantom-of-the-human-kidney-with-collecting-system
#14
Fabian Adams, Tian Qiu, Andrew Mark, Benjamin Fritz, Lena Kramer, Daniel Schlager, Ulrich Wetterauer, Arkadiusz Miernik, Peer Fischer
Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys...
November 9, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27826004/cell-infiltrative-hydrogel-fibrous-scaffolds-for-accelerated-wound-healing
#15
Xin Zhao, Xiaoming Sun, Lara Yildirimer, Qi Lang, Zhi Yuan William Lin, Reila Zheng, Yuguang Zhang, Wenguo Cui, Nasim Annabi, Ali Khademhosseini
: Development of natural protein-based fibrous scaffolds with tunable physical properties and biocompatibility is highly desirable to construct a three-dimensional (3D), fully cellularized scaffold for wound healing. Herein, we demonstrated a simple and effective technique to construct electrospun 3D fibrous scaffolds for accelerated wound healing using a photocrosslinkable hydrogel based on methacryloylated gelatin (GelMA). We found that the physical properties of the photocrosslinkable hydrogel including water retention, stiffness, strength, elasticity and degradation can be tailored by changing the light exposure time...
November 4, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27821857/establishing-antibacterial-multilayer-films-on-the-surface-of-direct-metal-laser-sintered-titanium-primed-with-phase-transited-lysozyme
#16
Binbin Guan, Haorong Wang, Ruiqing Xu, Guoying Zheng, Jie Yang, Zihao Liu, Man Cao, Mingyao Wu, Jinhua Song, Neng Li, Ting Li, Qing Cai, Xiaoping Yang, Yanqiu Li, Xu Zhang
Direct metal laser sintering is a technology that allows the fabrication of titanium (Ti) implants with a functional gradation of porosity and surface roughness according to three-dimensional (3D) computer data. The surface roughness of direct metal laser sintered titanium (DMLS-Ti) implants may provide abundant binding sites for bacteria. Bacterial colonization and subsequent biofilm formation can cause unsatisfactory cell adhesion and implant-related infections. To prevent such infections, a novel phase-transited lysozyme (PTL) was utilized as an initial functional layer to simply and effectively prime DMLS-Ti surfaces for subsequent coating with antibacterial multilayers...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27815012/three-dimensional-printed-final-occlusal-splint-for-orthognathic-surgery-design-and-validation
#17
E Shaheen, Y Sun, R Jacobs, C Politis
Orthognathic surgery is indicated for the treatment of significant skeletal malocclusion and is normally prepared using conventional face bows combined with two-dimensional cephalometric analysis and manually made splints. With recent developments in oral imaging, more orthognathic surgeries are being planned using three-dimensional computer-aided design and manufacturing (3D CAD/CAM) software. The purpose of this study was to present a protocol for the design and 3D printing of final digital occlusal splints based on 3D planning of orthognathic surgery and to validate the accuracy of these splints...
November 1, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27813008/lipid-membrane-encapsulation-of-a-3d-dna-nano-octahedron
#18
Steven D Perrault, William M Shih
Structural DNA nanotechnology methods such as DNA origami allow for the synthesis of highly precise nanometer-scale materials (Rothemund, Nature 440:297-302, 2006; Douglas et al., Nature 459:414-418, 2009). These offer compelling advantages for biomedical applications. Such materials can suffer from structural instability in biological environments due to denaturation and nuclease digestion (Hahn et al., ACS Nano 2014; Perrault and Shih, ACS Nano 8:5132-5140, 2014). Encapsulation of DNA nanostructures in a lipid membrane compartmentalizes them from their environment and prevents denaturation and nuclease digestion (Perrault and Shih, ACS Nano 8:5132-5140, 2014)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27806758/-biological-evaluation-of-three-dimensional-printed-co-poly-lactic-acid-glycolic-acid-tri-calcium-phosphate-scaffold-for-bone-reconstruction
#19
S Y Li, M Zhou, Y X Lai, Y M Geng, S S Cao, X M Chen
Objective: To biologically evaluate the three-dimensional(3D) printed co-poly lactic acid/glycolic acid/tri-calcium phosphate(PLGA/TCP) scaffold which could be used for repairing oral and maxillofacial bone defects, and to provide experimental evidence for its further research and clinical application. Methods: PLGA/TCP scaffolds were fabricated using low temperature rapid prototyping technique. Micro-CT and scanning electron microscope(SEM) were used to characterize the surface morphology. MC3T3-E1 cells were seeded onto the scaffold and stained with the rhodamine phalloidin and calcein acetomethoxy...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27805793/production-of-hollow-bacterial-cellulose-microspheres-using-microfluidics-to-form-an-injectable-porous-scaffold-for-wound-healing
#20
Jiaqing Yu, Tzu-Rung Huang, Zhen Han Lim, Rongcong Luo, Rupali Reddy Pasula, Lun-De Liao, Sierin Lim, Chia-Hung Chen
Bacterial cellulose (BC) is a biocompatible material with high purity and robust mechanical strength used to fabricate desirable scaffolds for 3D cell culture and wound healing. However, the chemical resistance of BC and its insolubility in the majority of solutions make it difficult to manipulate using standard chemical methods. In this study, a microfluidic process is developed to produce hollow BC microspheres with desirable internal structures and morphology. Microfluidics is used to generate a core-shell structured microparticle with an alginate core and agarose shell as a template to encapsulate Gluconacetobacter xylinus for long-term static culture...
November 2, 2016: Advanced Healthcare Materials
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