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3D biocompatibility

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https://www.readbyqxmd.com/read/28088072/microstructural-mechanical-and-corrosion-characteristics-of-heat-treated-mg-1-2zn-0-5ca-wt-alloy-for-use-as-resorbable-bone-fixation-material
#1
Hamdy Ibrahim, Andrew D Klarner, Behrang Poorganji, David Dean, Alan A Luo, Mohammad Elahinia
Mg-Zn-Ca alloys have grabbed most of the recent attention in research attempting to develop an Mg alloy for bone fixation devices due to their superior biocompatibility. However, early resorption and insufficient strength remain the main problems that hinder their use. Heat treatment has previously been thoroughly studied as a post-shaping process, especially after the fabrication of complex parts (e.g. porous structures) by 3D-printing or powder metallurgy. In this work, the effect of heat treatment on Mg-1...
January 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28079984/medical-application-of-glycosaminoglycans-a-review
#2
REVIEW
Alexander Köwitsch, Guoying Zhou, Thomas Groth
The characteristic molecular composition of the different glycosaminoglycans (GAG) is related to their role as structural components and regulators of a multitude of functions of proteins, cells and tissues in the human body. Therefore, it is not surprising that GAG are widely used as coating materials for implants, components of 3D-constructs like tissue engineering scaffolds and hydrogels, but also as diagnostic devices like biosensors and in controlled release applications. Beside a physisorption or encapsulation of GAG, these applications often require their chemical modification to allow a stable covalent attachment on surfaces or cross-linking reactions with other molecules...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28072428/3d-modelling-on-biodegradable-nanoparticle-enhanced-cryoablation-of-liver-tumor-based-on-real-anatomical-model
#3
S Y Xu, Z Z He, Y X Zhou, J Liu
BACKGROUND: Nanoparticle-enhanced freezing is of great importance for developing a conformal targeted cryoablation for liver tumor with complex shape. However, the safety and biocompatibility of nanoparticles should also be of major concerns. OBJECTIVE: This study is to investigate the enhanced cryoablation mediated by the MgO nanoparticles which are nontoxic, biodegradable, and have few side-effects on the human body. MATERIALS AND METHODS: A three-dimensional numerical model has been developed based on a real geometrical anatomical structure to characterize such nanocryosurgical freezing of liver tumor...
November 2016: Cryo Letters
https://www.readbyqxmd.com/read/28071597/three-dimensional-printing-of-a-microneedle-array-on-personalized-curved-surfaces-for-dual-pronged-treatment-of-trigger-finger
#4
Seng Han Lim, Jian Yao Ng, Lifeng Kang
The hand function of patients who suffer from trigger finger can be impaired by the use of traditional splints. There is also a risk of systemic side effects with oral non-steroidal anti-inflammatory drugs (NSAIDs) used for pain relief. Microneedle-assisted transdermal drug delivery offers an attractive alternative for local delivery of NSAIDs. However, traditional microneedle arrays fabricated on flat surfaces are unable to deliver drugs effectively across the undulating skin surface of affected finger(s)...
January 10, 2017: Biofabrication
https://www.readbyqxmd.com/read/28068621/formation-of-porous-hpcl-lpcl-ha-scaffolds-with-supercritical-co2-gas-foaming-method
#5
M Zahedi Moghadam, Sh Hassanajili, F Esmaeilzadeh, M Ayatollahi, M Ahmadi
Scaffold is a 3D porous structure that is made of different materials, such as synthetic and natural polymers. It plays the role of a synthetic extracellular matrix and permits adhesion, proliferation and differentiation of the cells. Porosity and pore size are the important factors for any 3D scaffold used in bone tissue engineering. In this study, porous scaffolds were prepared by adding hydroxyapatite (HA) nanoparticles as filler to the polymeric matrix of polycaprolactone (PCL) blends with two different molecular weight by using supercritical CO2 (ScCO2) foaming method...
January 3, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28049497/two-differentially-structured-collagen-scaffolds-for-potential-urinary-bladder-augmentation-proof-of-concept-study-in-a-g%C3%A3-ttingen-minipig-model
#6
Dorothea Leonhäuser, Katja Stollenwerk, Volker Seifarth, Isabella M Zraik, Michael Vogt, Pramod K Srinivasan, Rene H Tolba, Joachim O Grosse
BACKGROUND: The repair of urinary bladder tissue is a necessity for tissue loss due to cancer, trauma, or congenital abnormalities. Use of intestinal tissue is still the gold standard in the urological clinic, which leads to new problems and dysfunctions like mucus production, stone formation, and finally malignancies. Therefore, the use of artificial, biologically derived materials is a promising step towards the augmentation of this specialised tissue. The aim of this study was to investigate potential bladder wall repair by two collagen scaffold prototypes, OptiMaix 2D and 3D, naïve and seeded with autologous vesical cells, as potential bladder wall substitute material in a large animal model...
January 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28040366/3d-printed-transparent-facemasks-in-the-treatment-of-facial-hypertrophic-scars-of-young-children-with-burns
#7
Yating Wei, Cecilia W P Li-Tsang, Jun Liu, Lihua Xie, Shukai Yue
INTRODUCTION: Facial burns could create serious scar problems resulting disfigurement particularly on children. The conventional methods of producing transparent face masks for scar control remains complex and require dexterous skills of experienced clinician and patients' compliance during fitting. In this study, we adopted a portable 3D scanning and Computer-Aided Design (CAD) to produce 3D-printed transparent facemasks. Its efficacy was tested on two children with facial burns resulting hypertrophic scars...
December 28, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28028917/preparation-of-a-calcium-carbonate-based-bone-substitute-with-cinnamaldehyde-crosslinking-agent-with-potential-anti-inflammatory-properties
#8
Anne Handrini Dewi, Ika Dewi Ana, John Jansen
Calcium sulfate (CS), also known as POP (Plaster of Paris) is a self-setting, biocompatible and osteoconductive biomaterial with a long history for the treatment of skeletal defects. However, calcium sulfate cements show a too fast resorption rate and are unable to provide a long term 3D framework during the osteogenesis process. In our previous studies, it was found that the incorporation of CaCO3 and CaCO3 hydrogel provided enhanced mechanical and degradation properties of POP composites. Furthermore, it was also found that the use of cinnamaldehyde to crosslink CaCO3 hydrogel may have some advantages, e...
December 28, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28026926/3d-printing-biocompatible-polyurethane-poly-lactic-acid-graphene-oxide-nanocomposites-anisotropic-properties
#9
Qiyi Chen, Joey Dacula Mangadlao, Jaqueline D Wallat, Al Christopher C de Leon, Jonathan K Pokorski, Rigoberto C Advincula
Blending thermoplastic polyurethane (TPU) with poly (lactic acid) (PLA) is a proven method to achieve a much more mechanically-robust material while the addition of graphene oxide (GO) is increasingly applied in polymer nanocomposites to further tailor their properties. On the other hand, additive manufacturing (AM) has high flexibility of structure design which can significantly expand the application of materials in many fields. This study demonstrates the fused deposition modeling(FDM) 3D printing of TPU/PLA/GO nanocomposites and its potential application as biocompatible materials...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28024631/gold-nanoparticle-filled-biodegradable-photopolymer-scaffolds-induced-muscle-remodeling-in-vitro-and-in-vivo-findings
#10
Adam Zsedenyi, Balazs Farkas, Gaser N Abdelrasoul, Ilaria Romano, Edina Gyukity-Sebestyen, Katalin Nagy, Maria Harmati, Gabriella Dobra, Sandor Kormondi, Gabor Decsi, Istvan Balazs Nemeth, Alberto Diaspro, Fernando Brandi, Szabolcs Beke, Krisztina Buzas
Therapeutic stem cell transplantation bears the promise of new directions in organ and tissue replacement, but a number of its difficulties and perils are also well known. Our goal was to develop a method of transplantation by which the transplanted cells remain confined to the transplantation site and induce favorable processes. With the help of mask-projection excimer laser stereolithography, 3D hybrid nanoscaffolds were fabricated from biodegradable, photocurable PPF:DEF resin with incorporated gold nanoparticles (Au NPs)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024598/design-and-characterization-of-3d-hybrid-collagen-matrixes-as-a-dermal-substitute-in-skin-tissue-engineering
#11
Giriprasath Ramanathan, Sivakumar Singaravelu, Thangavelu Muthukumar, Sitalakshmi Thyagarajan, Paramasivan Thirumalai Perumal, Uma Tiruchirapalli Sivagnanam
The highly interconnected porous dressing material was fabricated with the utilization of novel collagen (COL-SPG) for the efficient healing of the wound. Herein, we report the fabrication of 3D collagen impregnated with bioactive extract (COL-SPG-CPE) to get rid of infection at the wound site. The resultant 3D collagen matrix was characterized physiochemically using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and mechanical property. The dressing substrate possesses the high swelling ability, increase in the porosity, in vitro enzymatic degradability and antibacterial property...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024594/an-injectable-poly-caprolactone-trifumarate-gelatin-microparticles-pcltf-gmps-scaffold-for-irregular-bone-defects-physical-and-mechanical-characteristics
#12
Nisreen Mohammed Al-Namnam, Muralithran Govindan Kutty, Wen Lin Chai, Kien Oon Ha, Kah Hwi Kim, Chong Huat Siar, Wei Cheong Ngeow
Recently, a modified form of a three-dimension (3D) porous poly(caprolactone-trifumarate) (PCLTF) scaffold has been produced using a fabrication technique that involves gelatin microparticles porogen leaching. This poly(caprolactone trifumarate-gelatin microparticles) (PCLTF-GMPs) scaffold has been shown to be biocompatible, more flowable clinically, and has a shorter degradation time as compared to its existing predecessors. In this report, a detailed characterization of this new scaffold was performed by testing its cytocompatibility, analyzing the surface topography, and understanding its thermal, physical and mechanical properties...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024569/strontium-hydroxyapatite-chitosan-nanohybrid-scaffolds-with-enhanced-osteoinductivity-for-bone-tissue-engineering
#13
Yong Lei, Zhengliang Xu, Qinfei Ke, Wenjing Yin, Yixuan Chen, Changqing Zhang, Yaping Guo
For the clinical application of bone tissue engineering with the combination of biomaterials and mesenchymal stem cells (MSCs), bone scaffolds should possess excellent biocompatibility and osteoinductivity to accelerate the repair of bone defects. Herein, strontium hydroxyapatite [SrHAP, Ca10-xSrx(PO4)6(OH)2]/chitosan (CS) nanohybrid scaffolds were fabricated by a freeze-drying method. The SrHAP nanocrystals with the different x values of 0, 1, 5 and 10 are abbreviated to HAP, Sr1HAP, Sr5HAP and Sr10HAP, respectively...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28009506/earthicle-the-design-of-a-conceptually-new-type-of-particle
#14
Vuk Uskoković, Sebastian Pernal, Victoria M Wu
The conception and the steps made in the design of a conceptually new type of composite particle, so-called "earthicle", are being described. This particle is meant to roughly mimic the layered structure of the Earth, having zerovalent iron core, silicate mantle, and a thin carbonaceous crust resembling the biosphere and its geological remnants. Particles are made in a stable colloidal form in an aqueous medium, involving chemical precipitation and pyrolysis of citric acid in the solution. The effects of various synthesis parameters were studied, including borohydride and oleate concentrations, APTES/TEOS molar ratio, chemical nature of the carbon precursors, and others...
January 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28008428/materials-and-scaffolds-in-medical-3d-printing-and-bioprinting-in-the-context-of-bone-regeneration
#15
Martin Heller, Heide-Katharina Bauer, Elisabeth Goetze, Matthias Gielisch, Ibrahim T Ozbolat, Kazim K Moncal, Elias Rizk, Hermann Seitz, Michael Gelinsky, Heinz C Schröder, Xiaohong H Wang, Werner E G Müller, Bilal Al-Nawas
The structural and functional repair of lost bone is still one of the biggest challenges in regenerative medicine. In many cases, autologous bone is used for the reconstruction of bone tissue; however, the availability of autologous material is limited, which always means additional stress to the patient. Due to this, more and more frequently various biocompatible materials are being used instead for bone augmentation. In this context, in order to ensure the structural function of the bone, scaffolds are implanted and fixed into the bone defect, depending on the medical indication...
2016: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28007548/enhanced-neuroprotection-with-decellularized-brain-extracellular-matrix-containing-bfgf-after-intracerebral-transplantation-in-parkinson-s-disease-rat-model
#16
Qian Lin, Ho Lun Wong, Fu-Rong Tian, Ya-Dong Huang, Jie Xu, Jing-Jing Yang, Pian-Pian Chen, Zi-Liang Fan, Cui-Tao Lu, Ying-Zheng Zhao
Extracellular matrix-based biomaterials have many advantages over synthetic polymer materials for regenerative medicine applications. In central nervous system (CNS), basic fibroblast growth factor (bFGF) is widely studied as a potential agent for Parkinson's disease (PD). However, the poor stability of bFGF hampered its clinical use. In this study, CNS-derived biologic scaffold containing bFGF was used to enhance and extend the neuroprotective effect of bFGF on PD targeted therapy. Decellularized brain extracellular matrix (dcBECM) was prepared by chemical extraction...
December 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28000756/a-magnetic-soft-endoscopic-capsule-inflated-intragastric-balloon-for-weight-management
#17
Thanh Nho Do, Khek Yu Ho, Soo Jay Phee
Overweight and obesity have been identified as a cause of high risk diseases like diabetes and cancer. Although conventional Intragastric Balloons (IGBs) have become an efficient and less invasive method for overweight and obesity treatment, the use of conventional tools such as catheter or endoscope to insert and remove the IGBs from the patient's body causes nausea, vomiting, discomfort, and even gastric mucous damage. To eliminate these drawbacks, we develop a novel magnetic soft capsule device with gas-filled balloon inflation...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000609/an-i-in-vitro-i-3d-model-using-collagen-coated-gelatin-nanofibers-for-studying-breast-cancer-metastasis
#18
Janani Guru, Mamatha Pillai, Selvakumar Rajendran, Amitava Bhattacharyya, Sabarinath Chandrasekharan
Study of breast cancer metastasis is limited due to poor knowledge in molecular progression of breast tumor and varied heterogeneity. For better understanding of tumor metastasis, a reliable 3D <i>in vitro</i> model bridging the gap between 2D cultures and <i>in vivo</i> animal model studies is highly needed. Our study is focused on two keypoints (i) designing a 3D microenvironment for studying metastasis and (ii) simulating the metastasis milieu by inducing epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET)...
December 21, 2016: Biofabrication
https://www.readbyqxmd.com/read/27998214/fabrication-of-a-highly-aligned-neural-scaffold-via-a-table-top-stereolithography-3d-printing-and-electrospinning
#19
Se-Jun Lee, Margaret Nowicki, Brent Harris, Lijie Grace Zhang
3D bioprinting is a rapidly emerging technique in the field of tissue engineering to fabricate extremely intricate and complex biomimetic scaffolds in the range of micrometers. Such customized 3D printed constructs can be used for the regeneration of complex tissues such as cartilage, vessels and nerves. However, the 3D printing techniques often offer limited control over the resolution and compromised mechanical properties due to short selection of printable inks. To address these limitation, we combined stereolithography and electrospinning techniques to fabricate a novel 3D biomimetic neural scaffold with a tunable porous structure and embedded aligned fibers...
December 21, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27995526/chitosan-based-matrices-prepared-by-gamma-irradiation-for-tissue-regeneration-structural-properties-vs-preparation-method
#20
REVIEW
Maria Helena Casimiro, Joana J H Lancastre, Alexandra P Rodrigues, Susana R Gomes, Gabriela Rodrigues, Luís M Ferreira
In the last decade, new generations of biopolymer-based materials have attracted attention, aiming its application as scaffolds for tissue engineering. These engineered three-dimensional scaffolds are designed to improve or replace damaged, missing, or otherwise compromised tissues or organs. Despite the number of promising methods that can be used to generate 3D cell-instructive matrices, the innovative nature of the present work relies on the application of ionizing radiation technology to form and modify surfaces and matrices with advantage over more conventional technologies (room temperature reaction, absence of harmful initiators or solvents, high penetration through the bulk materials, etc...
February 2017: Topics in Current Chemistry (Journal)
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