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3D biocompatibility

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https://www.readbyqxmd.com/read/29026706/development-of-novel-drug-eluting-stents-for-acute-myocardial-infarction
#1
REVIEW
Doo Sun Sim, Myung Ho Jeong
Delayed arterial healing at culprit sites after drug-eluting stent (DES) placement for acute myocardial infarction (AMI) is associated with increased risk of late stent thrombosis. The Korea Acute Myocardial Infarction Registry was established in commemoration of the 50(th) anniversary of Korea Circulation Society. Between November 2005 and December 2016, more than 62,000 patients were registered from 50 primary percutaneous coronary intervention (PCI) centers in Korea. DES in AMI may be safe and effective, however, there is concern about increased stent thrombosis after DES implantation in AMI patients, requiring longer-term dual anti-platelet therapy to reduce the risk of late stent thrombosis...
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28994582/internal-light-source-driven-photoelectrochemical-3d-rgo-cellulose-device-based-on-cascade-dna-amplification-strategy-integrating-target-analog-chain-and-dna-mimic-enzyme
#2
Feifei Lan, Linlin Liang, Yan Zhang, Li Li, Na Ren, Mei Yan, Shenguang Ge, Jinghua Yu
.In this work, a chemiluminescence-driven collapsible greeting card-like photoelectrochemical lab-on-paper device (GPECD) with hollow channel was demonstrated, in which target-triggering cascade DNA amplification strategy was ingeniously introduced. The GPECD had the functions of reagents storage and signal collection, and the change of configuration could control fluidic path, reaction time and alterations in electrical connectivity. In addition, three-dimentional reduced graphene oxide affixed Au flower was in situ grown on paper cellulose fiber for achieving excellent conductivity and biocompatibility...
October 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28985202/3d-bioprinting-using-stem-cells
#3
REVIEW
Chin Siang Ong, Pooja Yesantharao, Chen Yu Huang, Gunnar Mattson, Joseph Boktor, Takuma Fukunishi, Huaitao Zhang, Narutoshi Hibino
Recent advances have allowed for three-dimensional (3D) printing technologies to be applied to biocompatible materials, cells and supporting components, creating a field of 3D bioprinting that holds great promise for artificial organ printing and regenerative medicine. At the same time, stem cells, such as human induced pluripotent stem cells, have driven a paradigm shift in tissue regeneration and the modeling of human disease, and represent an unlimited cell source for tissue regeneration and the study of human disease...
October 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28976366/recombinant-spider-silk-based-bioinks
#4
Elise DeSimone, Kristin Schacht, Alexandra Pellert, Thomas Scheibel
Bioinks, 3D cell culture systems which can be printed, are still in the early development stages. Currently, extensive research is going into designing printers to be more accommodating to bioinks, designing scaffolds with stiff materials as support structures for the often soft bioinks, and modifying the bioinks themselves. Recombinant spider silk proteins, a potential biomaterial component for bioinks, have high biocompatibility, can be processed into several morphologies and can be modified with cell adhesion motifs to enhance their bioactivity...
October 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28972546/functionalization-of-biomedical-ti6al4v-via-in-situ-alloying-by-cu-during-laser-powder-bed-fusion-manufacturing
#5
Pavel Krakhmalev, Igor Yadroitsev, Ina Yadroitsava, Olga de Smidt
The modern medical industry successfully utilizes Laser Powder Bed Fusion (LPBF) to manufacture complex custom implants. Ti6Al4V is one of the most commonly used biocompatible alloys. In surgery practice, infection at the bone-implant interface is one of the key reasons for implant failure. Therefore, advanced implants with biocompatibility and antibacterial properties are required. Modification of Ti alloy with Cu, which in small concentrations is a proven non-toxic antibacterial agent, is an attractive way to manufacture implants with embedded antibacterial functionality...
October 3, 2017: Materials
https://www.readbyqxmd.com/read/28972200/fibrinogen-modified-sodium-alginate-as-a-scaffold-material-for-skin-tissue-engineering
#6
Elena V Solovieva, Alexander Yu Fedotov, Vasily E Mamonov, Vladimir S Komlev, Andrey A Panteleyev
In search for a new pro-angiogenic scaffold material suitable for skin bioengineering and grafting therapy, we have fabricated a number of composite sodium alginate (AG) - fibrinogen (FG) sponge scaffolds using the freeze-drying approach. Thrombin was added to drive FG/fibrin conversion, while ε-aminocapronic acid (εAc) was used as antifibrinolytic component. The slow rates of scaffold biodegradation were achieved by using Ca2+ and Mg2+ cations as cross-linking agents. The novel thrombin-modified AG-FG scaffolds with highly interconnected porous structure were evaluated using scanning electron microscopy, tensile testing and pycnometric analysis...
October 3, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28966095/3d-printing-of-hybrid-biomaterials-for-bone-tissue-engineering-calcium-polyphosphate-microparticles-encapsulated-by-polycaprolactone
#7
Meik Neufurth, Xiaohong Wang, Shunfeng Wang, Renate Steffen, Maximilian Ackermann, Natalie D Haep, Heinz C Schröder, Werner E G Müller
Here we describe the formulation of a morphogenetically active bio-ink consisting of amorphous microparticles (MP) prepared from Ca(2+) and the physiological inorganic polymer, polyphosphate (polyP). Those MP had been fortified by mixing with poly-ε-caprolactone (PCL) to allow 3D-bioprinting. The resulting granular PCL/Ca-polyP-MP hybrid material, liquefied by short-time heating to 100°C, was used for the 3D-printing of tissue-like scaffolds formed by strands with a thickness of 400 µm and a stacked architecture leaving ≈0...
September 28, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28955752/preparation-and-characterization-of-cockle-shell-aragonite-nanocomposite-porous-3d-scaffolds-for-bone-repair
#8
Saffanah Khuder Mahmood, Md Zuki Abu Bakar Zakaria, Intan Shameha Binti Abdul Razak, Loqman Mohamed Yusof, Alhaji Zubair Jaji, Isa Tijani, Nahidah Ibrahim Hammadi
The demands for applicable tissue-engineered scaffolds that can be used to repair load-bearing segmental bone defects (SBDs) is vital and in increasing demand. In this study, seven different combinations of 3 dimensional (3D) novel nanocomposite porous structured scaffolds were fabricated to rebuild SBDs using an extraordinary blend of cockle shells (CaCo3) nanoparticles (CCN), gelatin, dextran and dextrin to structure an ideal bone scaffold with adequate degradation rate using the Freeze Drying Method (FDM) and labeled as 5211, 5400, 6211, 6300, 7101, 7200 and 8100...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28953408/injectable-shear-thinning-fluorescent-hydrogel-formed-by-cellulose-nanocrystals-and-graphene-quantum-dots
#9
Amir Khabibullin, Moien Alizadehgiashi, Nancy Khuu, Elisabeth Prince, Moritz Tebbe, Eugenia Kumacheva
In the search for new building blocks of nanofibrillar hydrogels, cellulose nanocrystals (CNCs) have attracted great interest because of their sustainability, biocompatibility, ease of surface functionalization, and mechanical strength. Making these hydrogels fluorescent extends the range of their applications in tissue engineering, bioimaging, and biosensing. We report the preparation and properties of a multifunctional hydrogel formed by CNCs and graphene quantum dots (GQDs). We show that although CNCs and GQDs are both negatively charged, hydrogen bonding and hydrophobic interactions overcome the electrostatic repulsion between these nanoparticles and yield a physically cross-linked hydrogel with tunable mechanical properties...
October 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28952527/additive-manufacturing-of-poly-3-hydroxybutyrate-co-3-hydroxyhexanoate-poly-%C3%AE%C2%B5-caprolactone-blend-scaffolds-for-tissue-engineering
#10
Dario Puppi, Andrea Morelli, Federica Chiellini
Additive manufacturing of scaffolds made of a polyhydroxyalkanoate blended with another biocompatible polymer represents a cost-effective strategy for combining the advantages of the two blend components in order to develop tailored tissue engineering approaches. The aim of this study was the development of novel poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/ poly(ε-caprolactone) (PHBHHx/PCL) blend scaffolds for tissue engineering by means of computer-aided wet-spinning, a hybrid additive manufacturing technique suitable for processing polyhydroxyalkanoates dissolved in organic solvents...
May 24, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952490/photocurable-bioink-for-the-inkjet-3d-pharming-of-hydrophilic-drugs
#11
Giovanny F Acosta-Vélez, Chase S Linsley, Madison C Craig, Benjamin M Wu
Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry...
January 28, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952482/polysaccharide-fabrication-platforms-and-biocompatibility-assessment-as-candidate-wound-dressing-materials
#12
REVIEW
Donald C Aduba, Hu Yang
Wound dressings are critical for wound care because they provide a physical barrier between the injury site and outside environment, preventing further damage or infection. Wound dressings also manage and even encourage the wound healing process for proper recovery. Polysaccharide biopolymers are slowly becoming popular as modern wound dressings materials because they are naturally derived, highly abundant, inexpensive, absorbent, non-toxic and non-immunogenic. Polysaccharide biopolymers have also been processed into biomimetic platforms that offer a bioactive component in wound dressings that aid the healing process...
January 18, 2017: Bioengineering
https://www.readbyqxmd.com/read/28938862/rgdfk-peptide-modified-alginate-scaffold-for-cell-transplantation-and-cardiac-neovascularization
#13
Hugo Sondermeijer, Piotr Witkowski, Tetsunori Seki, Arnoud van der Laarse, Silviu Itescu, Mark Adam Hardy
Cell implantation for tissue repair is a promising new therapeutic strategy. Although direct injection of cells into tissue is appealing, cell viability and retention are not very good. Cell engraftment and survival following implantation are dependent on a sufficient supply of oxygen and nutrients via functional microcirculation as well as a suitable local microenvironment for implanted cells. Here, we describe the development of a porous, biocompatible, 3-dimensional alginate scaffold covalently modified with the synthetic cyclic RGDfK (Arg-Gly-Asp-D-Phe-Lys)-peptide...
September 22, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28934914/new-concept-of-3d-printed-bone-clip-polylactic-acid-hydroxyapatite-silk-composite-for-internal-fixation-of-bone-fractures
#14
Yeung Kyu Yeon, Hae Sang Park, Jung Min Lee, Ji Seung Lee, Young Jin Lee, Md Tipu Sultan, Ye Bin Seo, Ok Joo Lee, Soon Hee Kim, Chan Hum Park
Open reduction with internal fixation is commonly used for the treatment of bone fractures. However, postoperative infection associated with internal fixation devices (intramedullary nails, plates, and screws) remains a significant complication, and it is technically difficult to fix multiple fragmented bony fractures using internal fixation devices. In addition, drilling in the bone to install devices can lead to secondary fracture, bone necrosis associated with postoperative infection. In this study, we developed bone clip type internal fixation device using three- dimensional (3D) printing technology...
September 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28930358/fabrication-and-characterization-of-a-3d-bioprinted-nanoparticle-hydrogel-hybrid-device-for-biomimetic-detoxification
#15
Maggie S Chen, Yue Zhang, Liangfang Zhang
A biomimetic micro/nanodevice is 3D bioprinted using polyethylene glycol (PEG) hydrogel as the supporting platform, along with the red blood cell (RBC) membrane-coated nanoparticles (RBC-NPs) encapsulated in the hydrogel as the detoxification mechanism. RBC-NPs are prepared through a nanoprecipitation and coating method and then mixed into the poly(ethylene glycol) diacrylate (PEGDA) monomer solution for 3D bioprinting through photopolymerization. This resulting detoxification device is engineered with multiple inner channels for the RBC-NPs to nonspecifically soak up the various toxins flowing through the channels...
October 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28930091/proposal-to-assess-printability-of-bioinks-for-extrusion-based-bioprinting-and-evaluation-of-rheological-properties-governing-bioprintability
#16
Naomi Claire Paxton, Willi Smolan, Thomas Böck, Ferry P W Melchels, Juergen Groll, Tomasz Juengst
The development and formulation of printable inks for extrusion-based 3D bioprinting has been a major challenge in the field of biofabrication. Inks, often polymer solutions with the addition of crosslinking to form hydrogels, must not only display adequate mechanical properties for the chosen application, but also show high biocompatibility as well as printability. Here we describe a reproducible two-step method for the assessment of the printability of inks for bioprinting, focussing firstly on screening ink formulations to assess fibre formation and the ability to form 3D constructs before presenting a method for the rheological evaluation of inks to characterise the yield point, shear thinning and recovery behaviour...
September 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28929935/development-of-arginine-glycine-aspartate-immobilized-3d-printed-poly-propylene-fumarate-scaffolds-for-cartilage-tissue-engineering
#17
Chi Bum Ahn, Youngjo Kim, Sung Jean Park, Yongsung Hwang, Jin Woo Lee
Poly(propylene fumarate) (PPF) has known to be a good candidate material for cartilage tissue regeneration because of its excellent mechanical properties during its degradation processes. Here, we describe the potential application of PPF-based materials as 3D printing bioinks to create macroporous cell scaffolds using micro-stereolithography (MSTL). To improve cell-matrix interaction of seeded human chondrocytes within the PPF-based 3D scaffolds, we immobilized arginine-glycine-aspartate (RGD) peptide onto the PPF scaffolds...
September 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28929741/visible-light-neural-stimulation-on-graphitic-carbon-nitride-graphene-photocatalytic-fibers
#18
Zhongyang Zhang, Ruodan Xu, Zegao Wang, Mingdong Dong, Bianxiao Cui, Menglin Chen
Light stimulation allows remote and spatiotemporally accurate operation that has been applied as effective, noninvasive means of therapeutic interventions. Here, visible-light neural stimulation of graphitic carbon nitride (g-C3N4), an emerging photocatalyst with visible-light optoelectronic conversion, was for the first time investigated. Specifically, g-C3N4 was combined with graphene oxide (GO) in a three-dimensional manner on the surfaces of electrospun polycaprolactone/gelatin (PG) fibers and functioned as a biocompatible interface for visible-light stimulating neuronal differentiation...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925683/3d-nanostructured-palladium-functionalized-graphene-aerogel-supported-fe3o4-for-enhanced-ru-bpy-3-2-based-electrochemiluminescent-immunosensing-of-prostate-specific-antigen
#19
Lei Yang, Yueyuan Li, Yong Zhang, Dawei Fan, Xuehui Pang, Qin Wei, Bin Du
We developed a novel Ru(bpy)3(2+)-based electrochemiluminescence (ECL) immunosensor utilizing palladium nanoparticle (Pd NP)-functionalized graphene-aerogel-supported Fe3O4 (FGA-Pd) for real-sample analysis of prostate specific antigen (PSA). 3D nanostructured FGA-Pd, as a novel ECL carrier, was prepared by in situ reduction. Large amounts of Ru(bpy)3(2+) could combine with FGA-Pd via electrostatic interaction to establish a brand-new ECL emitter (Ru@FGA-Pd) for improving ECL efficiency. The obtained Ru@FGA-Pd composite was utilized to label the secondary antibody, which generated strong ECL signals with tripropylamine (TPrA) as a coreactant...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28923968/soft-tubular-microfluidics-for-2d-and-3d-applications
#20
Wang Xi, Fang Kong, Joo Chuan Yeo, Longteng Yu, Surabhi Sonam, Ming Dao, Xiaobo Gong, Chwee Teck Lim
Microfluidics has been the key component for many applications, including biomedical devices, chemical processors, microactuators, and even wearable devices. This technology relies on soft lithography fabrication which requires cleanroom facilities. Although popular, this method is expensive and labor-intensive. Furthermore, current conventional microfluidic chips precludes reconfiguration, making reiterations in design very time-consuming and costly. To address these intrinsic drawbacks of microfabrication, we present an alternative solution for the rapid prototyping of microfluidic elements such as microtubes, valves, and pumps...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
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