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3D biocompatibility

Daiheon Lee, Joseph P Park, Mi-Young Koh, Pureum Kim, Junhee Lee, Mikyung Shin, Haeshin Lee
Mussel-inspired adhesive coatings on biomedical devices have attracted significant interest due to their unique properties such as substrate independency and high efficiency. The key molecules for mussel-inspired adhesive coatings are catechol and amine groups. Along with the understanding of catechol chemistry, chitosan-catechol has also been developed as a representative mussel-inpired adhesive polymer that contains catechol and amine groups for adhesiveness. Herein, we demonstrated the direct writability of chitosan-catechol as a bioink for 3D printing, one of the additive techniques...
April 18, 2018: Biomaterials Science
Benjamin C Streifel, Jeffrey G Lundin, Allix M Sanders, Karli A Gold, Thomas S Wilems, Sierra J Williams, Elizabeth Cosgriff-Hernandez, James H Wynne
A novel hemostatic and absorbent wound dressing material compatible with 3D printing is developed to address deficiencies in current wound dressing protocol. The design involves an open celled, microporous hydrogel foam via a high internal phase emulsion (HIPE) template with biocompatible components and tunable hemostatic character by kaolin loading, the viscosity and cure kinetics of which are tailored for 3D printing applications. The use of nontoxic mineral oil organic phase results in cytocompatability with human dermal fibroblasts...
April 17, 2018: Macromolecular Bioscience
Yi Zhang, Yi Cheng, Cong Chen, Qi Liu, Xinyu Bi, Lei Duan, Jiamin Liu, Mengqi Wan, Lanye Huang, Ke Hu
Tumor metastasis and invasiveness are research hotspots in tumor therapy. Previous research demonstrated that cells expressing high level of CD36 might initiate metastasis in certain human oral carcinomas cell lines. Multicellular spheroids (MCS) culture technique has been extensively studied both in fundamental and applied research. In our previous research, we invented novel 3D anisotropic magnetic hydrogels (AMHs) which were composed of magnetic nanoparticle assemblies and biocompatible hydrogels. We further applied them as cell culture substrate in vitro...
March 1, 2018: Journal of Biomedical Nanotechnology
Qiuxia Fu, Cheng Duan, Zishuo Yan, Yan Li, Yang Si, Lifang Liu, Jianyong Yu, Bin Ding
Nanofiber-based hydrogels (NFHGs) prepared by the combination of traditional hydrogels and novel nanofibers have demonstrated great potential in various application fields, owing to their integrated advantages of superhydrophilicity, high water-holding capacity, good biocompatibility, enhanced mechanical strength, and excellent structural tenability. In this review, a comprehensive overview of the structure design and synthetic strategy of NFHGs derived from electrospinning technique, weaving, freeze-drying, 3D printing, and molecular self-assembling method is provided...
April 14, 2018: Macromolecular Rapid Communications
Xiaoxia Mao, Guifang Chen, Zihan Wang, Yuanguang Zhang, Xiaoli Zhu, Genxi Li
Hydrogels are of great interest in the field of biosensing for their good biocompatibility, plasticity, and capability of providing 3D scaffolds. Nevertheless, the application of hydrogels has not been linked with broad surface biosensing systems yet. To overcome the limitations, here for the first time, surface-immobilized pure DNA hydrogels were synthesized using a surficial primer-induced strategy and adopted for biosensing applications. The DNA hydrogel 3D scaffold is successfully constructed on a transparent ITO electrode, which facilitates both colourimetric and electrochemical measurements...
January 28, 2018: Chemical Science
Lingli Li, Conglie Lu, Lei Wang, Mei Chen, Jacinta F White, Xiaojuan Hao, Keith M McLean, Hao Chen, Timothy C Hughes
In this study, an injectable, photo-curable gelatin system, consisting of acrylated gelatin and thiolated gelatin, with tunable mechanical, biodegradation and biological properties was used as a potential cell supportive scaffold for the repair of focal corneal wounds. The mechanical property of hydrogels can be readily modified (post-cure shear modulus of between 0.3 and 22 kPa) by varying the ratio of acrylate to thiol groups, photo intensity and solids content, and the biodegradation times also varied with change of solids content...
April 5, 2018: ACS Applied Materials & Interfaces
Lu Lu
Electrochemical (bio)sensors have attracted much attention due to their high sensitivity, fast response time, biocompatibility, low cost and easy miniaturization. Specially, ever-growing necessity and interest have given rise to the fast development of electrochemical (bio)sensors for the detection of small biomolecules. They play enormous roles in the life processes with various biological function, such as life signal transmission, genetic expression and metabolism. Moreover, their amount in body can be used as an indicator for diagnosis of many diseases...
March 28, 2018: Biosensors & Bioelectronics
Margarita Zhuravleva, Zarema Gilazieva, Timofei E Grigoriev, Alexey D Shepelev, Timur Kh Tenchurin, Roman Kamyshinsky, Sergey V Krasheninnikov, Sergei Orlov, Gina Caralogli, Svetlana Archipova, Mark J Holterman, Mikhail Mavlikeev, Roman V Deev, Sergei N Chvalun, Paolo Macchiarini
Artificial tissue-engineered grafts offer a potential alternative to autologous tissue grafts for patients, which can be traumatic. After decellularizing Papio hamadryas esophagus and studying the morphology and physical properties of the extracellular matrix (ECM), we generated electrospun polyamide-6 based scaffolds to mimic it. The scaffolds supported a greater mechanical load than the native ECM and demonstrated similar 3D microstructure, with randomly aligned fibers, 90% porosity, 29 μm maximal pore size, and average fiber diameter of 2...
March 30, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
T Limongi, A Rocchi, F Cesca, H Tan, E Miele, A Giugni, M Orlando, M Perrone Donnorso, G Perozziello, Fabio Benfenati, Enzo Di Fabrizio
Biopolymers are increasingly employed for neuroscience applications as scaffolds to drive and promote neural regrowth, thanks to their ability to mediate the upload and subsequent release of active molecules and drugs. Synthetic degradable polymers are characterized by different responses ranging from tunable distension or shrinkage to total dissolution, depending on the function they are designed for. In this paper we present a biocompatible microfabricated poly-ε-caprolactone (PCL) scaffold for primary neuron growth and maturation that has been optimized for the in vitro controlled release of brain-derived neurotrophic factor (BDNF)...
March 29, 2018: Molecular Neurobiology
Cameron J Bloomquist, Michael B Mecham, Mark D Paradzinsky, Rima Janusziewicz, Samuel B Warner, J Christopher Luft, Sue J Mecham, Andrew Z Wang, Joseph M DeSimone
Mass customization along with the ability to generate designs using medical imaging data makes 3D printing an attractive method for the fabrication of patient-tailored drug and medical devices. Herein we describe the application of Continuous Liquid Interface Production (CLIP) as a method to fabricate biocompatible and drug-loaded devices with controlled release properties, using liquid resins containing active pharmaceutical ingredients (API). In this work, we characterize how the release kinetics of a model small molecule, rhodamine B-base (RhB), are affected by device geometry, network crosslink density, and the polymer composition of polycaprolactone- and poly (ethylene glycol)-based networks...
March 26, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Mojtaba Ghanbari Mehrabani, Ramin Karimian, Bahareh Mehramouz, Mahdi Rahimi, Hossein Samadi Kafil
One of the most serious challenge in wound care is difficulty of the infection control in wound healing process. Wound dressings with antimicrobial effects are useful to minimize the bacterial infections of wounds. In this study a biocompatible and biodegradable silk fibroin/chitin nanocomposite scaffolds with various content of silver nanoparticles (0.001, 0.01, and 0.1%) were fabricated via freeze-drying method for successful wound dressing application. The nanocomposite scaffolds have biocompatibility with high antimicrobial effects, good mechanical properties, and high porosity...
March 23, 2018: International Journal of Biological Macromolecules
Andrew Dobos, Taraka Sai Pavan Grandhi, Sudhakar Godeshala, Deirdre R Meldrum, Kaushal Rege
Scaffolds generated from naturally occurring and synthetic polymers have been investigated in several applications because of their biocompatibility and tunable chemo-mechanical properties. Existing methods for generation of 3D polymeric scaffolds typically cannot be parallelized, suffer from low throughputs, and do not allow for quick and easy removal of the fragile structures that are formed. Current molds used in hydrogel and scaffold fabrication using solvent casting and porogen leaching are often single-use and do not facilitate 3D scaffold formation in parallel...
March 25, 2018: Biotechnology and Bioengineering
Raquel Silva, Raminder Singh, Bapi Sarker, Dimitrios G Papageorgiou, Judith A Juhasz-Bortuzzo, Judith A Roether, Iwona Cicha, Joachim Kaschta, Dirk W Schubert, Konstantinos Chrissafis, Rainer Detsch, Aldo R Boccaccini
Hydrogels from natural polymers are widely used in tissue engineering due to their unique properties, especially when regarding the cell environment and their morphological similarity to the extracellular matrix (ECM) of native tissues. In this study, we describe the production and characterization of novel hybrid hydrogels composed of alginate blended with elastin from bovine neck ligament. The properties of elastin as a component of the native ECM were combined with the excellent chemical and mechanical stability as well as biocompatibility of alginate to produce two hybrid hydrogels geometries, namely 2D films obtained using sonication treatment and 3D microcapsules produced by pressure-driven extrusion...
March 20, 2018: International Journal of Biological Macromolecules
Héloïse Ragelle, Mark W Tibbitt, Shang-Yun Wu, Michael A Castillo, George Z Cheng, Sidharta P Gangadharan, Daniel G Anderson, Michael J Cima, Robert Langer
The proliferation of computer-aided design and additive manufacturing enables on-demand fabrication of complex, three-dimensional structures. However, combining the versatility of cell-laden hydrogels within the 3D printing process remains a challenge. Herein, we describe a facile and versatile method that integrates polymer networks (including hydrogels) with 3D-printed mechanical supports to fabricate multicomponent (bio)materials. The approach exploits surface tension to coat fenestrated surfaces with suspended liquid films that can be transformed into solid films...
March 22, 2018: Nature Communications
Hyunhee Ahn, Ravi R Patel, Anthony J Hoyt, Angela S P Lin, F Brennan Torstrick, Robert E Guldberg, Carl P Frick, R Dana Carpenter, Christopher M Yakacki, Nick J Willett
Poly(para-phenylene) (PPP) is a novel aromatic polymer with higher strength and stiffness than polyetheretherketone (PEEK), the gold standard material for polymeric load-bearing orthopaedic implants. The amorphous structure of PPP makes it relatively straightforward to manufacture different architectures, while maintaining mechanical properties. PPP is promising as a potential orthopaedic material; however, the biocompatibility and osseointegration have not been well investigated. The objective of this study was to evaluate biological and mechanical behavior of PPP, with or without porosity, in comparison to PEEK...
March 18, 2018: Acta Biomaterialia
Cristiane Patricia Pissinato Pere, Sophia N Economidou, Gurprit Lall, Clémentine Ziraud, Joshua S Boateng, Bruce D Alexander, Dimitrios A Lamprou, Dennis Douroumis
In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations., trehalose and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also facilitate rapid release rates. Circular dichroism and Raman analysis demonstrated that all carriers maintained the native form of insulin with xylitol presenting the best performance...
March 16, 2018: International Journal of Pharmaceutics
Yuan-Sheng Lee, Nirveek Bhattacharjee, Albert Folch
Here we demonstrate a 3D-printable microvalve that is transparent, built with a biocompatible resin, and has a simple architecture that can be easily scaled up into large arrays. The open-at-rest valve design is derived from Quake's PDMS valve design. We used a stereolithographic (SL) 3D printer to print a thin (25 or 10 μm-thick) membrane (1200 or 500 μm-diam.) that is pneumatically pressed (∼3-6 psi) over a bowl-shaped seat to close the valve. We used poly(ethylene diacrylate) (MW = 258) (PEG-DA-258) as the resin because it yields transparent cytocompatible prints...
March 19, 2018: Lab on a Chip
Magdalini Tsintou, Kyriakos Dalamagkas, Alexander Seifalian
Central Nervous System (CNS) repair has been a challenge, due to limited CNS tissue regenerative capacity. The emerging tools that neural engineering has to offer have opened new pathways towards the discovery of novel therapeutic approaches for CNS disorders. Collagen has been a preferable material for neural tissue engineering due to its similarity to the extracellular matrix, its biocompatibility, and antigenicity. The aim was to compare properties of a plastically compressed collagen hydrogel with the ones of a promising collagen-genipin injectable hydrogel and a collagen-only hydrogel for clinical CNS therapy applications...
2018: International Journal of Biomaterials
Karteek Kadimisetty, Jinzhao Song, Aoife M Doto, Young Hwang, Jing Peng, Michael G Mauk, Frederic D Bushman, Robert Gross, Joseph N Jarvis, Changchun Liu
Molecular diagnostics that involve nucleic acid amplification tests (NAATs) are crucial for prevention and treatment of infectious diseases. In this study, we developed a simple, inexpensive, disposable, fully 3D printed microfluidic reactor array that is capable of carrying out extraction, concentration and isothermal amplification of nucleic acids in variety of body fluids. The method allows rapid molecular diagnostic tests for infectious diseases at point of care. A simple leak-proof polymerization strategy was developed to integrate flow-through nucleic acid isolation membranes into microfluidic devices, yielding a multifunctional diagnostic platform...
March 10, 2018: Biosensors & Bioelectronics
Tao Li, Mingzheng Peng, Zezheng Yang, Xiaojun Zhou, Yuan Deng, Chuan Jiang, Ming Xiao, Jinwu Wang
To promote vascularization of tissue-engineered bone, IFN-γ polarizing macrophages to M1 was loaded on 5% calcium silicate/β-tricalcium phosphate (CaSiO3 -β-TCP) scaffolds. IFN-γ and Si released from the scaffold were designed to polarize M1 and M2 macrophages, respectively. β-TCP, CaSiO3 -β-TCP, and IFN-γ@CaSiO3 -β-TCP were fabricated and biocompatibilities were evaluated. Polarizations of macrophages were detected by flow cytometry. Human umbilical vein endothelial cells with GFP were cultured and induced on Matrigel with conditioned culture medium extracted from culture of macrophages loaded on scaffolds for evaluating angiogenesis...
March 13, 2018: Acta Biomaterialia
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