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https://www.readbyqxmd.com/read/28726576/recent-developments-in-thiolated-polymeric-hydrogels-for-tissue-engineering-applications
#1
Mani Gajendiran, Jae-Sung Rhee, Kyobum Kim
This review focuses on the recent strategy in the preparation of thiolated polymers and fabrication of their hydrogel matrices. The mechanism involved in the synthesis of thiolated polymers and fabrication of thiolated polymer hydrogels is exemplified with suitable schematic representations reported in the recent literature. The 2-iminothiolane namely "Traut's reagent" has been widely employed for effectively thiolating the natural polymers such as collagen and gelatin which contain free amino group in their back bone...
July 20, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28717129/3d-printed-scaffolds-of-calcium-silicate-doped-%C3%AE-tcp-synergize-with-co-cultured-endothelial-and-stromal-cells-to-promote-vascularization-and-bone-formation
#2
Yuan Deng, Chuan Jiang, Cuidi Li, Tao Li, Mingzheng Peng, Jinwu Wang, Kerong Dai
Synthetic bone scaffolds have potential application in repairing large bone defects, however, inefficient vascularization after implantation remains the major issue of graft failure. Herein, porous β-tricalcium phosphate (β-TCP) scaffolds with calcium silicate (CS) were 3D printed, and pre-seeded with co-cultured human umbilical cord vein endothelial cells (HUVECs) and human bone marrow stromal cells (hBMSCs) to construct tissue engineering scaffolds with accelerated vascularization and better bone formation...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715970/scaffold-in-scaffold-potential-to-induce-growth-and-differentiation-of-cardiac-progenitor-cells
#3
Matteo Ciocci, Federico Mochi, Felicia Carotenuto, Emilia Di Giovanni, Paolo Prosposito, Roberto Francini, Fabio De Matteis, Igor Reshetov, Mauro Casalboni, Sonia Melino, Paolo Di Nardo
The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical signals concurring to modulate cell function to ultimately drive cell fate. In the present study, a combination of optimal mechanical and biochemical properties has been considered to design a one-component 3D multitextured hydrogel scaffold in order to favor cell-scaffold interactions...
July 17, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28715113/calcium-deposition-in-photocrosslinked-poly-pro-hyp-gly-hydrogels-encapsulated-rat-bone-marrow-stromal-cells
#4
Farah Nurlidar, Keisuke Yamane, Mime Kobayashi, Kayo Terada, Tsuyoshi Ando, Masao Tanihara
Reproducing the features of the extracellular matrix is important for fabricating three-dimensional (3D) scaffolds for tissue regeneration. A collagen-like polypeptide, poly(Pro-Hyp-Gly), is a promising material for 3D scaffolds because of its excellent physical properties, biocompatibility, and biodegradability. In this paper, we present a novel photocrosslinked poly(Pro-Hyp-Gly) hydrogel as a 3D scaffold for simultaneous rat bone marrow stromal cell (rBMSC) encapsulation. The hydrogels were fabricated using visible-light photocrosslinking at various concentrations of methacrylated poly(Pro-Hyp-Gly) (20-50 mg/mL) and irradiation times (3 or 5 min)...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28709910/silicon-zinc-glycerol-hydrogel-a-potential-immunotropic-agent-for-topical-application
#5
Tat'yana G Khonina, Maria V Ivanenko, Oleg N Chupakhin, Alexander P Safronov, Ekaterina A Bogdanova, Maxim S Karabanalov, Vasily V Permikin, Leonid P Larionov, Lyudmila I Drozdova
Nanoparticles synthesized using sol-gel method are promising agents for biomedical applications, in particular for the therapy and diagnosis of various diseases. Using silicon and zinc glycerolates as biocompatible precursors we synthesized by the sol-gel method a new bioactive silicon-zinc-containing glycerohydrogel combining the positive pharmacological properties of the precursors. In the present work the structural features of silicon-zinc-containing glycerohydrogel and its immunotropic properties were studied...
July 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28699619/highly-defined-3d-printed-chitosan-scaffolds-featuring-improved-cell-growth
#6
Lisa Elviri, Ruben Foresti, Carlo Bergonzi, Francesca Zimetti, Cinzia Marchi, Annalisa Bianchera, Franco Bernini, Marco Silvestri, Ruggero Bettini
The augmented demand for medical devices devoted to tissue regeneration and possessing a controlled micro-architecture means there is a need for industrial scale-up in the production of hydrogels. A new 3D printing technique was applied to the automation of a freeze-gelation method for the preparation of chitosan scaffolds with controlled porosity. For this aim, a dedicated 3D printer was built in-house: a preliminary effort has been necessary to explore the printing parameter space to optimize the printing results in terms of geometry, tolerances and mechanical properties of the product...
July 12, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28699281/promoting-cell-migration-in-tissue-engineering-scaffolds-with-graded-channels
#7
Degang Yang, Zhitong Zhao, Fan Bai, Shutao Wang, Antoni P Tomsia, Hao Bai
Ideal bone scaffolds having good biocompatibility, good biodegradability, and beneficial mechanical properties are the basis for bone tissue engineering. Specifically, cell migration within 3D scaffolds is crucial for bone regeneration of critical size defects. In this research, hydroxyapatite scaffolds with three different types of architectures (tortuous, parallel, and graded channels) are fabricated using the freeze-casting (ice-templating) method. While most studies promote cell migration by chemical factors, it can be greatly enhanced by introducing only graded channels as compared with tortuous or parallel channels...
July 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28698531/microfluidic-platform-for-the-long-term-on-chip-cultivation-of-mammalian-cells-for-lab-on-a-chip-applications
#8
Frank Bunge, Sander van den Driesche, Michael J Vellekoop
Lab-on-a-Chip (LoC) applications for the long-term analysis of mammalian cells are still very rare due to the lack of convenient cell cultivation devices. The difficulties are the integration of suitable supply structures, the need of expensive equipment like an incubator and sophisticated pumps as well as the choice of material. The presented device is made out of hard, but non-cytotoxic materials (silicon and glass) and contains two vertical arranged membranes out of hydrogel. The porous membranes are used to separate the culture chamber from two supply channels for gases and nutrients...
July 10, 2017: Sensors
https://www.readbyqxmd.com/read/28686242/keratin-dissolution-extraction-and-biomedical-application
#9
REVIEW
Amin Shavandi, Tiago H Silva, Adnan A Bekhit, Alaa El-Din A Bekhit
Keratinous materials such as wool, feathers and hooves are tough unique biological co-products that usually have high sulfur and protein contents. A high cystine content (7-13%) differentiates keratins from other structural proteins, such as collagen and elastin. Dissolution and extraction of keratin is a difficult process compared to other natural polymers, such as chitosan, starch, collagen, and a large-scale use of keratin depends on employing a relatively fast, cost-effective and time efficient extraction method...
July 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28677805/designer-d-form-self-assembling-peptide-scaffolds-promote-the-proliferation-and-migration-of-rat-bone-marrow-derived-mesenchymal-stem-cells
#10
Shuo Chen, Ao Zhou, Bin He, Weikang Zhao, Xiaojun Chen, Dianming Jiang
Self-assembling peptide (SAP) nanofiber hydrogel scaffolds have become increasingly important in tissue engineering due to their outstanding bioactivity and biodegradability. However, there is an initial concern on their long-term clinical use, since SAPs made of L-form amino acid sequences are sensitive to enzymatic degradation. In this study, we present a designer SAP, D-RADA16, made of all D-amino acid. We investigated the nanofiber morphology of D-RADA16, its potential for the culture of bone marrow-derived mesenchymal stem cells (BMSCs), and the proteolytic resistance of the biomaterial...
July 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28672214/polysaccharide-matrices-used-in-3d-in%C3%A2-vitro-cell-culture-systems
#11
REVIEW
Dorina Diekjürgen, David W Grainger
Polysaccharides comprise a diverse class of polymeric materials with a history of proven biocompatibility and continual use as biomaterials. Recent focus on new matrices appropriate for three-dimensional (3D) cell culture offers new opportunities to apply polysaccharides as extracellular matrix mimics. However, chemical and structural bases for specific cell-polysaccharide interactions essential for their utility as 3-D cell matrices are not well defined. This review describes how these naturally sourced biomaterials satisfy several key properties for current 3D cell culture needs and can also be synthetically modified or blended with additional components to tailor their cell engagement properties...
June 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/28671759/electroactive-3d-scaffolds-based-on-silk-fibroin-and-water-borne-polyaniline-for-skeletal-muscle-tissue-engineering
#12
Mengyao Zhang, Baolin Guo
Silk fibroin (SF) with good biocompatibility and degradability has great potential for tissue engineering. However, the SF based scaffolds lack the electroactivity to regulate the myogenic differentiation for the regeneration of muscle tissue, which is sensitive to electrical signal. Herein, a series of electroactive biodegradable scaffolds based on SF and water-soluble conductive poly(aniline-co-N-(4-sulfophenyl) aniline) (PASA) via a green method for skeletal muscle tissue engineering are designed. SF/PASA scaffolds are prepared by vortex of aqueous solution of SF and PASA under physiological condition...
July 3, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28661650/superflexible-wood
#13
Jianwei Song, Chaoji Chen, Chengwei Wang, Yudi Kuang, Yongfeng Li, Feng Jiang, Yiju Li, Emily Hitz, Ying Zhang, Boyang Liu, Amy Gong, Huiyang Bian, J Y Zhu, Jianhua Zhang, Jun Li, Liangbing Hu
Flexible porous membranes have attracted increasing scientific interest due to their wide applications in flexible electronics, energy storage devices, sensors, and bioscaffolds. Here, inspired by nature, we develop a facile and scalable top-down approach for fabricating a superflexible, biocompatible, biodegradable three-dimensional (3D) porous membrane directly from natural wood (coded as flexible wood membrane) via a one-step chemical treatment. The superflexibility is attributed to both physical and chemical changes of the natural wood, particularly formation of the wavy structure formed by simple delignification induced by partial removal of lignin/hemicellulose...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28659629/engineering-biodegradable-and-biocompatible-bio-ionic-liquid-conjugated-hydrogels-with-tunable-conductivity-and-mechanical-properties
#14
Iman Noshadi, Brian W Walker, Roberto Portillo-Lara, Ehsan Shirzaei Sani, Nayara Gomes, Mohammad Reza Aziziyan, Nasim Annabi
Conventional methods to engineer electroconductive hydrogels (ECHs) through the incorporation of conductive nanomaterials and polymers exhibit major technical limitations. These are mainly associated with the cytotoxicity, as well as poor solubility, processability, and biodegradability of their components. Here, we describe the engineering of a new class of ECHs through the functionalization of non-conductive polymers with a conductive choline-based bio-ionic liquid (Bio-IL). Bio-IL conjugated hydrogels exhibited a wide range of highly tunable physical properties, remarkable in vitro and in vivo biocompatibility, and high electrical conductivity without the need for additional conductive components...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28653854/a-thermogelling-supramolecular-hydrogel-with-sponge-like-morphology-as-a-cytocompatible-bioink
#15
Thomas Lorson, Sebastian Jaksch, Michael M Lübtow, Tomasz Jüngst, Jürgen Groll, Tessa Lühmann, Robert Luxenhofer
Biocompatible polymers that form thermoreversible supramolecular hydrogels have gained great interest in biomaterials research and tissue engineering. When favorable rheological properties are achieved at the same time, they are particularly promising candidates as material that allow for the printing of cells, so-called bioinks. We synthesized a novel thermogelling block copolymer and investigated the rheological properties of its aqueous solution by viscosimetry and rheology. The polymers undergo thermogelation between room temperature and body temperature, form transparent hydrogels of surprisingly high strength (G' > 1000 Pa) and show rapid and complete shear recovery after stress...
June 27, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28653043/bioactive-polymeric-scaffolds-for-tissue-engineering
#16
Scott Stratton, Namdev B Shelke, Kazunori Hoshino, Swetha Rudraiah, Sangamesh G Kumbar
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity...
December 2016: Bioactive Materials
https://www.readbyqxmd.com/read/28645662/development-of-a-3d-printable-maxillofacial-silicone-part-ii-optimization-of-moderator-and-thixotropic-agent
#17
Swati K Jindal, Martyn Sherriff, Mark G Waters, James E Smay, Trevor J Coward
STATEMENT OF PROBLEM: Conventionally, maxillofacial prostheses are fabricated by hand carving the missing anatomic defect in wax and creating a mold into which pigmented silicone elastomer is placed. Digital technologies such as computer numerical control milling and 3-dimensional (3D) printing have been used to prepare molds, directly or indirectly, into which a biocompatible pigmented silicone elastomer can be placed. PURPOSE: The purpose of this in vitro study was to develop a silicone elastomer that could be 3D printed directly without a mold to create facial or body prostheses by varying its composition...
June 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28639959/3d-printing-current-use-in-facial-plastic-and-reconstructive-surgery
#18
Tsung-Yen Hsieh, Raj Dedhia, Brian Cervenka, Travis T Tollefson
PURPOSE OF REVIEW: To review the use of three-dimensional (3D) printing in facial plastic and reconstructive surgery, with a focus on current uses in surgical training, surgical planning, clinical outcomes, and biomedical research. To evaluate the limitations and future implications of 3D printing in facial plastic and reconstructive surgery. RECENT FINDINGS: Studies reviewed demonstrated 3D printing applications in surgical planning including accurate anatomic biomodels, surgical cutting guides in reconstruction, and patient-specific implants fabrication...
August 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28636315/fabrication-of-hierarchical-macroporous-biocompatible-scaffolds-by-combining-pickering-high-internal-phase-emulsion-templates-with-three-dimensional-printing
#19
Ting Yang, Yang Hu, Chaoyang Wang, Bernard P Binks
Biocompatible and biodegradable porous scaffolds with adjustable pore structure have aroused increasing interest in bone tissue engineering. Here, we report a facile method to fabricate hierarchical macroporous biocompatible (HmPB) scaffolds by combining Pickering high internal phase emulsion (HIPE) templates with three-dimensional (3D) printing. HmPB scaffolds composed of a polymer matrix of poly(l-lactic acid), PLLA, and poly(ε-caprolactone), PCL, are readily fabricated by solvent evaporation of 3D printed Pickering HIPEs which are stabilized by hydrophobically modified silica nanoparticles (h-SiO2)...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28629097/emerging-bone-tissue-engineering-via-polyhydroxyalkanoate-pha-based-scaffolds
#20
REVIEW
Janice Lim, Mingliang You, Jian Li, Zibiao Li
Polyhydroxyalkanoates (PHAs) are a class of biodegradable polymers derived from microorganisms. On top of their biodegradability and biocompatibility, different PHA types can contribute to varying mechanical and chemical properties. This has led to increasing attention to the use of PHAs in numerous biomedical applications over the past few decades. Bone tissue engineering refers to the regeneration of new bone through providing mechanical support while inducing cell growth on the PHA scaffolds having a porous structure for tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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