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3D biocompatibility

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https://www.readbyqxmd.com/read/29236117/liquid-crystal-elastomer-foams-with-elastic-properties-specifically-engineered-as-biodegradable-brain-tissue-scaffolds
#1
M E Prévôt, H Andro, S L M Alexander, S Ustunel, C Zhu, Z Nikolov, S T Rafferty, M T Brannum, B Kinsel, L T J Korley, E J Freeman, J A McDonough, R J Clements, E Hegmann
Tissue regeneration requires 3-dimensional (3D) smart materials as scaffolds to promote transport of nutrients. To mimic mechanical properties of extracellular matrices, biocompatible polymers have been widely studied and a diverse range of 3D scaffolds have been produced. We propose the use of responsive polymeric materials to create dynamic substrates for cell culture, which goes beyond designing only a physical static 3D scaffold. Here, we demonstrated that lactone- and lactide-based star block-copolymers (SBCs), where a liquid crystal (LC) moiety has been attached as a side-group, can be crosslinked to obtain Liquid Crystal Elastomers (LCEs) with a porous architecture using a salt-leaching method to promote cell infiltration...
December 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29232108/biocompatible-electroactive-tetra-aniline-conjugated-peptide-nanofibers-for-neural-differentiation
#2
Idil Arioz, Ozlem Erol, Gokhan Bakan, F Begum Dikecoglu, Ahmet Emin Topal, Mustafa Urel, Aykutlu Dana, Ayse B Tekinay, Mustafa O Guler
Peripheral nerve injuries cause devastating problems for the quality of the patients' lives and regeneration following a damage to the peripheral nervous system is limited depending on the degree of the damage. Use of nanobiomaterials can provide therapeutic approaches for the treatment of peripheral nerve injuries. Electroactive biomaterials, in particular, can provide a promising cure for the regeneration of nerve defects. Here, a supramolecular electroactive nanosystem with tetra(aniline) (TA) containing peptide nanofibers was developed and utilized for nerve regeneration...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29231281/novel-3d-neuron-regeneration-scaffolds-based-on-synthetic-polypeptide-containing-neuron-cue
#3
Zhen-Hua Wang, Yen-Yu Chang, Jhih-Guang Wu, Chia-Yu Lin, Hsiao-Lung An, Shyh-Chyang Luo, Tang K Tang, Wei-Fang Su
Neural tissue engineering has become a potential technology to restore the functionality of damaged neural tissue with the hope to cure the patients with neural disorder and to improve their quality of life. This paper reports the design and synthesis of polypeptides containing neuron stimulate, glutamic acid, for the fabrication of biomimetic 3D scaffold in neural tissue engineering application. The polypeptides are synthesized by efficient chemical reactions. Monomer γ-benzyl glutamate-N-carboxyanhydride undergoes ring-opening polymerization to form poly(γ-benzyl-l-glutamate), then hydrolyzes into poly(γ-benzyl-l-glutamate)-r-poly(glutamic acid) random copolymer...
December 12, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29228474/controlled-electrospray-generation-of-non-spherical-alginate-microparticles
#4
Morteza Jeyhani, Sze Yi Mak, Stephen Sammut, Ho Cheung Shum, Dae Kun Hwang, Scott Tsai
Electrospraying is a technique used to generate microparticles in a high throughput manner. For biomedical applications, a biocompatible electrosprayed material is often desirable. Using polymers, such as alginate hydrogels, makes it possible to create biocompatible and biodegradable microparticles that can be used for cell encapsulation, to be employed as drug carriers, and for use in 3D cell culturing. Evidence in the literature suggests that the morphology of the biocompatible microparticles is relevant in controlling the dynamics of the microparticles in drug delivery and 3D cell culturing applications...
December 11, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29225151/injectable-in-situ-forming-gel-based-on-lyotropic-liquid-crystal-for-persistent-postoperative-analgesia
#5
Liling Mei, Yecheng Xie, Ying Huang, Bei Wang, Jintian Chen, Guilan Quan, Xin Pan, Hu Liu, Lili Wang, Xianguo Liu, Chuanbin Wu
Local anesthetics have been widely used for postoperative analgesia. However, multiple injections or local infiltration is required due to the short half-lives of local anesthetics after single injection, which results in poor compliance and increasing medical expense. In this study, an in situ forming gel (ISFG) based on lyotropic liquid crystal was developed to deliver bupivacaine hydrochloride (BUP) for long-acting postoperative analgesia. BUP-ISFG was designed to be administrated as a precursor solution which would spontaneously transform into gel with well-defined internal nanostructures for sustained drug release at the site of administration when exposed to physiological fluid...
December 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29214803/shear-thinning-and-thermo-reversible-nanoengineered-inks-for-3d-bioprinting
#6
Scott A Wilson, Lauren M Cross, Charles W Peak, Akhilesh K Gaharwar
Three-dimensional (3D) printing is an emerging approach for rapid fabrication of complex tissue structures using cell-loaded bioinks. However, 3D bioprinting has hit a bottleneck in progress because of the lack of suitable bioinks that are printable, have high shape fidelity, and are mechanically resilient. In this study, we introduce a new family of nanoengineered bioinks consisting of kappa-carrageenan (κCA) and two-dimensional (2D) nanosilicates (nSi). κCA is a biocompatible, linear, sulfated polysaccharide derived from red algae and can undergo thermo-reversible and ionic gelation...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29214219/3d-printing-of-bacteria-into-functional-complex-materials
#7
Manuel Schaffner, Patrick A Rühs, Fergal Coulter, Samuel Kilcher, André R Studart
Despite recent advances to control the spatial composition and dynamic functionalities of bacteria embedded in materials, bacterial localization into complex three-dimensional (3D) geometries remains a major challenge. We demonstrate a 3D printing approach to create bacteria-derived functional materials by combining the natural diverse metabolism of bacteria with the shape design freedom of additive manufacturing. To achieve this, we embedded bacteria in a biocompatible and functionalized 3D printing ink and printed two types of "living materials" capable of degrading pollutants and of producing medically relevant bacterial cellulose...
December 2017: Science Advances
https://www.readbyqxmd.com/read/29203812/a-highly-printable-and-biocompatible-hydrogel-composite-for-direct-printing-of-soft-and-perfusable-vasculature-like-structures
#8
Ratima Suntornnond, Edgar Yong Sheng Tan, Jia An, Chee Kai Chua
Vascularization is one major obstacle in bioprinting and tissue engineering. In order to create thick tissues or organs that can function like original body parts, the presence of a perfusable vascular system is essential. However, it is challenging to bioprint a hydrogel-based three-dimensional vasculature-like structure in a single step. In this paper, we report a new hydrogel-based composite that offers impressive printability, shape integrity, and biocompatibility for 3D bioprinting of a perfusable complex vasculature-like structure...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29186036/a-new-bone-substitute-developed-from-3d-prints-of-polylactide-pla-loaded-with-collagen-i-an-in-vitro-study
#9
Ulrike Ritz, Rebekka Gerke, Hermann Götz, Stefan Stein, Pol Maria Rommens
Although a lot of research has been performed, large segmental bone defects caused by trauma, infection, bone tumors or revision surgeries still represent big challenges for trauma surgeons. New and innovative bone substitutes are needed. Three-dimensional (3D) printing is a novel procedure to create 3D porous scaffolds that can be used for bone tissue engineering. In the present study, solid discs as well as porous cage-like 3D prints made of polylactide (PLA) are coated or filled with collagen, respectively, and tested for biocompatibility and endotoxin contamination...
November 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29183847/breath-figures-in-tissue-engineering-and-drug-delivery-state-of-the-art-and-future-perspectives
#10
REVIEW
Maria Teresa Calejo, Tanja Ilmarinen, Heli Skottman, Minna Kellomäki
The breath figure (BF) method is an easy, low-cost method to prepare films with a highly organized honeycomb-like porous surface. The particular surface topography and porous nature of these materials makes them valuable substrates for studying the complex effects of topography on cell fate, and to produce biomimetic materials with high performance in tissue engineering. Numerous researchers over the last two decades have studied the effects of the honeycomb topography on a variety of primary and immortalized cell lines, and drew important conclusions that can be translated to the construction of optimal biomaterials for cell culture...
November 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29172145/a-novel-3d-bioprinted-flexible-and-biocompatible-hydrogel-bioelectronic-platform
#11
Shweta Agarwala, Jia Min Lee, Wei Long Ng, Michael Layani, Wai Yee Yeong, Shlomo Magdassi
Bioelectronics platforms are gaining widespread attention as they provide a template to study the interactions between biological species and electronics. Decoding the effect of the electrical signals on the cells and tissues holds the promise for treating the malignant tissue growth, regenerating organs and engineering new-age medical devices. This work is a step forward in this direction, where bio- and electronic materials co-exist on one platform without any need for post processing. We fabricate a freestanding and flexible hydrogel based platform using 3D bioprinting...
November 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29167720/peek-polymer-in-orthodontics-a-pilot-study-on-children
#12
Gaetano Ierardo, Valeria Luzzi, Michela Lesti, Iole Vozza, Orlando Brugnoletti, Antonella Polimeni, Maurizio Bossù
The purpose of the study has been making the orthodontic space maintainers in PEEK polymer (Polyetheretherketone) through a digital workflow. New digital technologies are taking hold in diagnosis, therapy and in dental laboratories. The digital world can help dentist in diagnosis and therapy: -diagnosis through the acquisition of radiographic images (CBCT) or scanners which allow the creation of 3D digital models - about therapy thanks to dental CAD CAM system. It consists of design devices through an dedicated software CAD and then realize devices through CAM system...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29154874/preparation-and-characterization-of-three-dimensional-scaffolds-based-on-hydroxypropyl-chitosan-graft-graphene-oxide
#13
P R Sivashankari, A Moorthi, K Mohamed Abudhahir, M Prabaharan
Hydroxypropyl chitosan (HPCH), a water soluble derivative of chitosan, is widely considered for tissue engineering and wound healing applications due to its biocompatibility and biodegradability. Graphene oxide (GO) is a carbon-based nanomaterial which is capable of imparting desired properties to the scaffolds. Hence, the integration of GO into HPCH could allow for the production of HPCH-based scaffolds with improved swelling character, mechanical strength, and stability aimed at being used in tissue engineering...
November 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29134412/engineered-bone-scaffolds-with-dielectrophoresis-based-patterning-using-3d-printing
#14
Zhijie Huan, Henry K Chu, Hongbo Liu, Jie Yang, Dong Sun
Patterning of cells into a specific pattern is an important procedure in tissue engineering to facilitate tissue culture and ingrowth. In this paper, a new type of 3D-printed scaffold utilizing dielectrophoresis (DEP) for active cell seeding and patterning was proposed. This scaffold adopted a concentric-ring design that is similar to native bone tissues. The scaffold was fabricated with a commercial three-dimensional (3D) printer. Polylactic Acid (PLA) was selected as the material for the printer and the fabricated scaffold was coated with gold to enhance the conductivity for DEP manipulation...
November 13, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29129026/micromechanical-study-of-the-load-transfer-in-a-polycaprolactone-collagen-hybrid-scaffold-when-subjected-to-unconfined-and-confined-compression
#15
A P G Castro, D Lacroix
Scaffolds are used in diverse tissue engineering applications as hosts for cell proliferation and extracellular matrix formation. One of the most used tissue engineering materials is collagen, which is well known to be a natural biomaterial, also frequently used as cell substrate, given its natural abundance and intrinsic biocompatibility. This study aims to evaluate how the macroscopic biomechanical stimuli applied on a construct made of polycaprolactone scaffold embedded in a collagen substrate translate into microscopic stimuli at the cell level...
November 11, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29128598/histological-and-radiological-evaluation-of-subcutaneous-implants-in-mouse-of-a-3d-printable-material-fulcure-720-and-experimental-application-in-mandibular-reconstruction
#16
J Megías Barrera, L García-Consuegra, A Novoa, S Costilla, S Junquera, G Ascani
INTRODUCTION: The aim of this study was to evaluate the bioactivity of FullCure compared to porous polyethylene implants (Medpor) in rats prior to custom-made scaffold support manufacturing for mandible segmental defects (MSD) reconstruction in sheep. METHODS: 12 Fullcure and Medpor laminaes were implanted in the left and right dorsum respectively of 6 wistar rats. Toxicity was assessed by skin, kidney and liver histopathology 3 months post-implantation. Computed Tomography (CT) was carried out in order to assess radiological differences between implants...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29121558/high-performance-and-versatile-electrochemical-aptasensor-based-on-self-supported-nanoporous-gold-microelectrode-and-enzyme-induced-signal-amplification
#17
Lei Shi, Xiaojiao Rong, Yan Wang, Shiming Ding, Wanying Tang
Herein, novel and versatile electrochemical aptasensors were constructed on a self-supported nanoporous gold (np-Au) microelectrode, integrating with an exonuclease III (Exo III) induced signal amplification strategy. Self-supported np-Au microelectrode with 3D bicontinuous nanoporous structures possesses tremendously large specific area, clean surface, high stability and biocompatibility, bringing about significant advantages in both molecular recognition and signal response. As paradigms, two analytes of bisphenol A (BPA) and ochratoxin A (OTA) were selected to demonstrate the superiority and versatility of designed aptasensors...
November 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29114098/production-of-composite-scaffold-containing-silk-fibroin-chitosan-and-gelatin-for-3d-cell-culture-and-bone-tissue-regeneration
#18
Jianqing Li, Qiuke Wang, Yebo Gu, Yu Zhu, Liang Chen, Yunfeng Chen
BACKGROUND Bone tissue engineering, a powerful tool to treat bone defects, is highly dependent on use of scaffolds. Both silk fibroin (SF) and chitosan (Cs) are biocompatible and actively studied for reconstruction of tissue engineering. Gelatin (Gel) is also widely applied in the biomedical field due to its low antigenicity and physicochemical stability. MATERIAL AND METHODS In this study, 4 different types of scaffolds were constructed - SF, SF/Cs, SF/Gel, and SF/Cs/Gel - and we compared their physical and chemical properties as well as biological characterization of these scaffolds to determine the most suitable scaffold for use in bone regeneration...
November 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29111850/chitosan-based-coatings-in-the-prevention-of-intravascular-catheter-associated-infections
#19
Gracia Mendoza, Anna Regiel-Futyra, Alejandra Tamayo, Marta Monzon, Silvia Irusta, Miguel Angel de Gregorio, Agnieszka Kyzioł, Manuel Arruebo
Central venous access devices play an important role in patients with prolonged intravenous administration requirements. In the last years, the coating of these devices with bactericidal compounds has emerged as a potential tool to prevent bacterial colonization. Our study describes the modification of 3D-printed reservoirs and silicone-based catheters, mimicking central venous access devices, through different approaches including their coating with the well known biocompatible and bactericidal polymer chitosan, with the anionic polysaccharide alginate; also, plasma treated surfaces were included in the study to promote polymer adhesion...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29111048/ultra-high-mechanical-properties-of-porous-composites-based-on-regenerated-cellulose-and-cross-linked-poly-ethylene-glycol
#20
Jian Teng, Biao Yang, Liang-Qing Zhang, Sheng-Qiang Lin, Ling Xu, Gan-Ji Zhong, Jian-Hua Tang, Zhong-Ming Li
The ultra-high mechanical, biocompatible and biodegradable porous regenerated cellulose/poly(ethylene glycol) (RC/PEG) composites with double network structure were fabricated via an simple method to dissolve cellulose followed by UV irradiation. The porous structure of RC/PEG was sensitively altered by PEG contents, which led to the porous structure morphology transition from 3D fibrillar network to close-grained sheet-like-network with the loading of cross-linked PEG. The porous RC/PEG showed excellent mechanical properties, i...
January 1, 2018: Carbohydrate Polymers
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