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Young adult breast cancer

Abhishek Bhandari, Melissa Woodhouse, Samir Gupta
Colorectal cancer (CRC) incidence and mortality are rising among young adults. Our aim was to contrast the relative incidence and mortality of CRC to other common cancers among young adults in the USA. We used Surveillance, Epidemiology, and End Results registry data to compare cancer site-specific and age-specific mortality and incident rates for adults younger than age 50. We summarized extracted data, both overall, and stratified by sex. We found CRC was the third leading cause of cancer death among adults younger than age 50, after breast and lung cancer (1...
November 18, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Mary Peavey, Sara Arian, William Gibbons, Karen Lu, David Gershenson, Terri Woodard
PURPOSE: Adolescents and young adults (AYAs) receiving cancer treatments that may impair fertility should receive counseling about risk of infertility and options for fertility preservation (FP) before treatment and/or during survivorship. Our objective was to define the AYA patient population referred to an on-site fertility consultation service within a comprehensive cancer center and determine factors associated with patients proceeding with FP treatment. METHODS: We conducted a retrospective chart review of AYA women who completed a consultation at the MD Anderson Fertility Preservation and Family Building Service during the first year of service...
November 15, 2016: Journal of Adolescent and Young Adult Oncology
Katherine E Henson, Raoul C Reulen, David L Winter, Chloe J Bright, Miranda M Fidler, Clare Frobisher, Joyeeta Guha, Kwok F Wong, Julie Kelly, Angela B Edgar, Martin G McCabe, Jeremy Whelan, David J Cutter, Sarah C Darby, Mike M Hawkins
BACKGROUND: Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly of cardiac disease that is increased in other cancer populations where cardiotoxic treatments have been used. METHODS: The Teenage and Young Adult Cancer Survivor Study cohort comprises 200 945 5-year survivors of cancer diagnosed at 15 to 39 years of age in England and Wales from 1971 to 2006, and followed to 2014...
November 15, 2016: Circulation
Rahul Gosain, YaoYao Pollock, Dharamvir Jain
Aging poses an unique opportunity to study cancer biology and treatment in older adults. Breast cancer is often studied in young women; however, much investigation remains to be done on breast cancer in our expanding elderly population. Diagnostic and management strategies applicable to younger patients cannot be empirically used to manage older breast cancer patients. Lack of evidence-based data continues to be the major impediment toward delivery of personalized cancer care to elderly breast cancer patients...
November 2016: Current Oncology Reports
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Amanda Eng, Mona Jeffreys, Martin O Leach, David Hawkes, Isabel Dos Santos Silva
BACKGROUND: Breast density, the amount of fibroglandular tissue in the adult breast for a women's age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events early in life. In the present study, we investigated the association between pre-natal exposures and breast tissue composition. METHODS: A sample of 500 young, nulliparous women (aged approximately 21 years) from a U...
October 12, 2016: Breast Cancer Research: BCR
Emilie Cordina-Duverger, Thérèse Truong, Antoinette Anger, Marie Sanchez, Patrick Arveux, Pierre Kerbrat, Pascal Guénel
BACKGROUND: Overweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain over the lifetime in postmenopausal breast cancer is not well documented. METHODS: We conducted a population-based case-control study on breast cancer in France that included 739 cases and 815 population controls in postmenopausal women. Height, weight at age 20, 40 and 50 as well as weight one year before diagnosis were obtained during in-person interviews...
September 29, 2016: BMC Cancer
Devin C Flaherty, Rashmi Bawa, Claire Burton, Melanie Goldfarb
BACKGROUND: Breast cancer is one of the most common cancers in female adolescent and young adults (AYA; age 15-39 years). However, few data exist detailing either in situ or invasive breast cancer in male AYAs. METHODS: All male AYA breast cancer cases were identified in the National Cancer Data Base (1998-2010). Demographics, tumor, and treatment predictors of overall survival (OS) were determined for both patients with in situ and invasive tumors. RESULTS: Of 677 male AYAs, 122 patients (18 %) had in situ breast cancer, while 555 patients (82 %) were found to have invasive breast cancer...
September 20, 2016: Annals of Surgical Oncology
Akemi Kataoka, Takayuki Iwamoto, Eriko Tokunaga, Ai Tomotaki, Hiraku Kumamaru, Hiroaki Miyata, Naoki Niikura, Masaaki Kawai, Keisei Anan, Naoki Hayashi, Shinobu Masuda, Koichiro Tsugawa, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Takayuki Kinoshita, Seigo Nakamura, Yutaka Tokuda
PURPOSE: The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. METHODS: Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 %), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35-50 years), and older adult (OA; >50 years) patients...
November 2016: Breast Cancer Research and Treatment
Valérie Laurence, Maria Marples, Daniel P Stark
The pattern of cancer seen in young people changes with increasing age, transitioning from childhood- to adult-type cancer in adolescence and the third decade. The risk factors, presentation and biology of cancer in young adults differ from those in the older adult population. Factors of particular significance in adolescents and young adults (AYAs) include genetic predisposition to adult-type cancer, diagnostic uncertainty, long-term morbidity and considerations of fertility. New systemic therapies are being introduced that can prolong life and even increase the chance of cure, but the impact on AYAs is uncertain, as these patients are often under-represented in clinical trials...
2016: Progress in Tumor Research
Marco Perez, Javier Peinado-Serrano, Jose Manuel Garcia-Heredia, Irene Felipe-Abrio, Cristina Tous, Irene Ferrer, Javier Martin-Broto, Carmen Saez, Amancio Carnero
Sarcomas are malignant tumors accounting for a high percentage of cancer morbidity and mortality in children and young adults. Surgery and radiation therapy are the accepted treatments for most sarcomas; however, patients with metastatic disease are treated with systemic chemotherapy. Many tumors display marginal levels of chemoresponsiveness, and new treatment approaches are needed. MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas. The levels of MAP17 could be used as a prognostic marker to predict the response to bortezomib in hematological malignancies and in breast tumors...
August 22, 2016: Oncotarget
Amanda N Henning, Jill D Haag, Bart M G Smits, Michael N Gould
In understanding the etiology of breast cancer, the contributions of both genetic and environmental risk factors are further complicated by the impact of breast developmental stage. Specifically, the time period ranging from childhood to young adulthood represents a critical developmental window in a woman's life when she is more susceptible to environmental hazards that may affect future breast cancer risk. Although the effects of environmental exposures during particular developmental Windows of Susceptibility (WOS) are well documented, the genetic mechanisms governing these interactions are largely unknown...
August 2016: PLoS Genetics
Sara Giordano, Elizabeth Garrett-Mayer, Navdha Mittal, Kristin Smith, Lee Shulman, Carolyn Passaglia, William Gradishar, Mary Ellen Pavone
PURPOSE: Mutations in the BRCA1/2 genes are associated with breast and ovarian cancer susceptibility. Recent studies have suggested that the BRCA mutation might be associated with occult primary ovarian insufficiency. To evaluate fertility, several studies have validated anti-Mullerian hormone (AMH) as a direct biomarker for ovarian aging and it is considered a quantitative marker of ovarian reserve. We hypothesize that BRCA1 gene mutations will be negatively associated with AMH levels...
August 11, 2016: Journal of Adolescent and Young Adult Oncology
Julie Williams Merten, Alexander Parker, Adrienne Williams, Jessica L King, Erin Largo-Wight, Morsal Osmani
Cancer is the second leading cause of death in the USA. Incidence and mortality rates for cancer have risen steadily and cost the healthcare system over $264 billion annually. Cancer risk can be reduced by restricting alcohol consumption, avoiding tobacco, eating a balanced diet, limiting sun exposure, exercising, and seeking routine cancer screenings. The purpose of this study is to examine cancer risk factor knowledge among college students. Researchers surveyed undergraduate and graduate students (n = 758) at a mid-sized public university in the Southeast about their knowledge regarding cancer risk factors including smoking, alcohol consumption, diet, obesity, hypertension, and human papillomavirus (HPV)...
August 6, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Giovanna Mariscotti, Paolo Belli, Daniela Bernardi, Beniamino Brancato, Massimo Calabrese, Luca A Carbonaro, Beatrice Cavallo-Marincola, Francesca Caumo, Paola Clauser, Laura Martinchich, Stefania Montemezzi, Pietro Panizza, Federica Pediconi, Alberto Tagliafico, Rubina M Trimboli, Chiara Zuiani, Francesco Sardanelli
Women who underwent chest radiation therapy (CRT) during pediatric/young-adult age (typically, lymphoma survivors) have an increased breast cancer risk, in particular for high doses. The cumulative incidence from 40 to 45 years of age is 13-20 %, similar to that of BRCA mutation carriers for whom contrast-enhanced magnetic resonance imaging (MRI) is recommended. However, in women who underwent CRT, MRI sensitivity is lower (63-80 %) and that of mammography higher (67-70 %) than those observed in women with hereditary predisposition, due to a higher incidence of ductal carcinoma in situ with microcalcifications and low neoangiogenesis...
July 12, 2016: La Radiologia Medica
Chung-Sik Oh, Seung-Hyun Lee, Young-Bum Yoo, Jung-Hyun Yang, Seong-Hyop Kim
Distribution of A118G single nucleotide polymorphism (SNP) in the mu-opioid receptor 1 gene (OPRM1) differs with ethnicity. We assessed the distribution of this SNP in Korean women with breast cancer and compared it with that in women of other ethnicities with breast cancer. Distribution of SNP genotypes was as follows: 49.8% for AG genotype, 40.6% for AA genotype, and 9.6% for GG genotype. Logistic regression analysis showed a negative association between the presence of the G allele at position 118 of OPRM1 and breast cancer in the studied population (odds ratios [OR], 0...
June 2016: Journal of Breast Cancer
Sadeer G Al-Kindi, Guilherme H Oliveira
AIM: To describe the incidence of cardiovascular mortality (CVM) in survivors of major cancers and identify its trends over the past two decades. METHODS: We used the surveillance, epidemiology and end-results 19 registry to identify young adults (20-49 years), diagnosed with the following major primary cancers: Lung, breast, liver/intrahepatic bile duct, pancreas, prostate, colorectal, and ovarian from 1990 through 2012 and identified the cumulative incidence of CVM after adjusting for confounding factors...
June 26, 2016: World Journal of Cardiology
Adebola A Adedimeji, David Lounsbury, Oluwafemi Popoola, Chioma Asuzu, Akinmayowa Lawal, V Oladoyin, Cassandra Crifase, Ilir Agalliu, Viswanathan Shankar, Akindele Adebiyi
BACKGROUND: Cancers constitute a significant public health problem in Nigeria. Breast, cervix and prostate cancers are leading causes of cancer-related deaths. Changing diets, lifestyles, HIV/AIDS and macro-structural factors contribute to cancer morbidity and mortality. Poor health information linking cancer risk to individual behaviors, environmental pollutants and structural barriers undermine prevention/control efforts. Studies suggest increasing health literacy and empowering individuals to take preventive action will improve outcomes and mitigate impact on a weak health system...
May 24, 2016: Psycho-oncology
Kimberly A Bertrand, Heather J Baer, E John Orav, Catherine Klifa, Ajay Kumar, Nola M Hylton, Erin S LeBlanc, Linda G Snetselaar, Linda Van Horn, Joanne F Dorgan
BACKGROUND: Emerging evidence suggests positive associations between serum anti-Müllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk. METHODS: We examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC)...
July 2016: Cancer Epidemiology, Biomarkers & Prevention
Luca Gianni, Tadeusz Pienkowski, Young-Hyuck Im, Ling-Ming Tseng, Mei-Ching Liu, Ana Lluch, Elżbieta Starosławska, Juan de la Haba-Rodriguez, Seock-Ah Im, Jose Luiz Pedrini, Brigitte Poirier, Paolo Morandi, Vladimir Semiglazov, Vichien Srimuninnimit, Giulia Valeria Bianchi, Domenico Magazzù, Virginia McNally, Hannah Douthwaite, Graham Ross, Pinuccia Valagussa
BACKGROUND: In the primary analysis of the NeoSphere trial, patients given neoadjuvant pertuzumab, trastuzumab, and docetaxel showed a significantly improved pathological complete response compared with those given trastuzumab and docetaxel after surgery. Here, we report 5-year progression-free survival, disease-free survival, and safety. METHODS: In this multicentre, open-label, phase 2 randomised trial in hospitals and medical clinics, treatment-naive adults with locally advanced, inflammatory, or early-stage HER2-positive breast cancer were randomly assigned (1:1:1:1) to receive four neoadjuvant cycles of trastuzumab (8 mg/kg loading dose, followed by 6 mg/kg every 3 weeks) plus docetaxel (75 mg/m(2) every 3 weeks, increasing to 100 mg/m(2) from cycle 2 if tolerated; group A), pertuzumab (840 mg loading dose, followed by 420 mg every 3 weeks) and trastuzumab plus docetaxel (group B), pertuzumab and trastuzumab (group C), or pertuzumab and docetaxel (group D)...
June 2016: Lancet Oncology
Randeep Singh, Rashmi Shirali, Sonali Chatterjee, Arun Adhana, Ramandeep Singh Arora
BACKGROUND AND OBJECTIVES: Although cancer in adolescents and young adults (AYAs) is increasingly an area of focus, there is a paucity of clinical and epidemiological data from developing countries. Our objective was to analyze the geographical distribution, sex ratio, histology, and disease patterns of cancers in AYA. MATERIALS AND METHODS: All patients aged 15-29 years with the diagnosis of cancer who were registered with two hospitals in New Delhi during a 12-month period from January 2014 to December 2014 were included...
April 2016: Indian Journal of Medical and Paediatric Oncology
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