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https://www.readbyqxmd.com/read/29221139/epstein-barr-virus-in-tumor-infiltrating-b-cells-of-myasthenia-gravis-thymoma-an-innocent-bystander-or-an-autoimmunity-mediator
#1
Paola Cavalcante, Stefania Marcuzzo, Sara Franzi, Barbara Galbardi, Lorenzo Maggi, Teresio Motta, Raffaella Ghislandi, Antonella Buzzi, Luisella Spinelli, Lorenzo Novellino, Fulvio Baggi, Carlo Antozzi, Fabio Conforti, Tommaso Martino De Pas, Massimo Barberis, Pia Bernasconi, Renato Mantegazza
The thymus plays a key role in myasthenia gravis (MG), a B cell-mediated autoimmune disorder affecting neuromuscular junction. Most MG patients have thymic abnormalities, including hyperplasia and thymoma, a neoplasm of thymic epithelial cells. Epstein-Barr virus (EBV) is associated with autoimmune diseases and tumors. Recently, we showed EBV persistence and reactivation in hyperplastic MG thymuses, suggesting that EBV might contribute to intra-thymic B cell dysregulation in MG patients. Here, we investigated EBV involvement in thymoma-associated MG, by searching for EBV markers in MG (n=26) and non-MG (n=14) thymomas...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219030/laser-atherectomy-combined-with-drug-coated-balloon-angioplasty-is-associated-with-improved-1-year-outcomes-for-treatment-of-femoropopliteal-in-stent-restenosis
#2
Damianos G Kokkinidis, Prio Hossain, Omar Jawaid, Bejan Alvandi, T Raymond Foley, Gagan D Singh, Stephen W Waldo, John R Laird, Ehrin J Armstrong
PURPOSE: To examine whether laser atherectomy combined with drug-coated balloons (laser + DCB) can improve the outcomes of femoropopliteal (FP) in-stent restenosis (ISR). METHODS: A dual-center retrospective study was conducted of 112 consecutive patients (mean age 70.3±10.6 years; 86 men) with Tosaka class II (n=29; diffuse stenosis) or III (n=83; occlusion) FP-ISR lesions. Sixty-two patients (mean age 68.5±10 years; 51 men) underwent laser + DCB while the other 50 patients (mean age 72...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29214713/stent-graft-treatment-for-infra-inguinal-arterial-disease-for-either-instent-restenosis-and-denovo-lesions-associated-with-very-high-rates-of-failure
#3
Maheswara S Golla, Subasit Acharji, Timir K Paul, Praveena Madapathi, Lawrence A Garcia
BACKGROUND: FDA approved the Gore Viabahn (WL Gore, Flagstaff, AZ, USA) stent for both femoro-popliteal arterial denovo and instent restenosis (ISRS) lesions. To date there is little data on Viabahn stent graft outcomes in ISRS arterial disease. METHODS: Between 2007 and 2014 we identified 734 patients who underwent 1573 endovascular interventions in our institution for infra-inguinal revascularization. Among these, 48 patients had 143 Viabahn stents placed. Of these, 26 patients had 94 stents placed for ISRS and 22 patients had 49 stents placed for denovo lesions...
December 7, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29211884/impact-of-current-and-past-cancer-history-on-the-risk-of-cardiovascular-events-following-percutaneous-coronary-intervention-a-kumamoto-university-malignancy-and-atherosclerosis-kuma-study
#4
Noriaki Tabata, Daisuke Sueta, Eiichiro Yamamoto, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Kenshi Yamanaga, Masanobu Ishii, Kenji Sakamoto, Hisanori Kanazawa, Koichiro Fujisue, Shinsuke Hanatani, Hirofumi Soejima, Seiji Hokimoto, Yasuhiro Izumiya, Sunao Kojima, Hiroshige Yamabe, Koichi Kaikita, Kenichi Tsujita
Background: As progress is made in successfully treating cancer, there is increasing need to focus on the risk and complexity of treating cardiovascular events in cancer survivors - thus, the field of onco-cardiology/cardio-oncology has emerged. We examined the differential incidence of cardiovascular events after percutaneous coronary intervention (PCI) in patients with or without cancer. Methods and Results: Participants were divided into a non-cancer group and a cancer group, which consisted of patients who were receiving or had ever received cancer treatment...
December 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29208238/toll-like-receptor-2-mediates-local-innate-immune-response-against-trypanosoma-cruzi-in-ex%C3%A2-vivo-infected-human-placental-chorionic-villi-explants
#5
Christian Castillo, Lorena Muñoz, Ileana Carrillo, Ana Liempi, Lisvaneth Medina, Norbel Galanti, Juan Diego Maya, Ulrike Kemmerling
BACKGROUND: Congenital Chagas disease is caused by the protozoan parasite Trypanosoma cruzi that must cross the placental barrier during transmission. The trophoblast constitutes the first tissue in contact with the maternal-blood circulating parasite. Importantly, the congenital transmission rates are low, suggesting the presence of local placental defense mechanisms. On the other hand, the placenta is considered an immune regulatory organ since it acts as a modulator of fetal and maternal immune responses...
December 2017: Placenta
https://www.readbyqxmd.com/read/29205492/9-month-results-of-polymer-free-sirolimus-eluting-stents-in-young-patients-compared-to-a-septuagenarian-and-octogenarian-all-comer-population
#6
Behrouz Kherad, Matthias Waliszewski, Matthias Leschke, Muhammad Ali Kader, Liew Houng Bang, Fernando Lozano Ruiz-Poveda, Burkert Pieske, Florian Krackhardt
OBJECTIVES: To evaluate the 9-month safety and efficacy of polymer-free sirolimus eluting drug eluting stents in septuagenarians and octogenarians. METHODS: An all-comer, worldwide single armed trial (ClinicalTrials.gov Identifier NCT02629575) was conducted to demonstrate the safety and efficacy of an ultra-thin strut, polymer-free sirolimus eluting stent (PF-SES). The primary endpoint was the 9-month target revascularization rate (TLR). Secondary endpoints included the rates of major adverse cardiac events (MACE), stent thrombosis (ST) and bleeding (BARC) in septuagenarians (≥70 years, <80 years), and in octogenarians (≥80 years) to be compared to the younger patient group (<70 years)...
December 4, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29203209/comparative-efficacy-of-two-paclitaxel-coated-balloons-with-different-excipient-coatings-in-patients-with-coronary-in-stent-restenosis-a-pooled-analysis-of-the-intracoronary-stenting-and-angiographic-results-optimizing-treatment-of-drug-eluting-stent-in-stent
#7
Roisin Colleran, Michael Joner, Sebastian Kufner, Felix Altevogt, Franz-Josef Neumann, Mohamed Abdel-Wahab, Janika Bohner, Christian Valina, Gert Richardt, Bernhard Zrenner, Salvatore Cassese, Tareq Ibrahim, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Robert A Byrne
BACKGROUND: Angioplasty with paclitaxel-coated balloons (PCB) is recommended for treatment of patients with coronary in-stent restenosis (ISR) according to European clinical practice guidelines. Most clinical trials have investigated iopromide-based PCB and there is a paucity of data comparing efficacy against butyryl-tri-hexyl citrate (BTHC)-based PCB. Our aim was to compare the performance of two widely-used PCB in the treatment of coronary ISR. METHODS: We analysed patients treated with BTHC- or iopromide-PCB for treatment of drug-eluting stent ISR in the setting of 2 consecutive trials with identical inclusion and exclusion criteria...
November 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29201195/anti-nociceptive-effect-of-dexmedetomidine-in-a-rat-model-of-monoarthritis-via-suppression-of-the-tlr4-nf-%C3%AE%C2%BAb-p65-pathway
#8
Dong Ji, Yalan Zhou, Shuangshuang Li, Dai Li, Hui Chen, Yuanchang Xiong, Yuqiu Zhang, Hua Xu
As a therapeutic target for neuropathic pain, the anti-nociceptive effects of α 2-adrenoceptors (α2AR) have attracted attention. Dexmedetomidine (DEX), a potent and highly selective α2AR agonist, has exhibited significant analgesic effects in neuropathic pain, but the underlying mechanism has remained elusive. The present study investigated the effect of DEX on Toll-like receptor (TLR)4 and nuclear factor (NF)-κB p65 expression, as well as the production of pro-inflammatory cytokines. The rat monoarthritis (MA) model was induced by intra-articular injection of complete Freund's adjuvant (CFA) at the ankle joint...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29199612/involvement-of-different-genes-expressions-during-immunological-and-inflammatory-responses-in-vitiligo
#9
Chandra Kant Sharma, Monika Sharma, Kanika Prasad
Vitiligo is a condition of the skin distinguished by hypo-pigmentation. Etiology of this disorder is unknown, and several theories and mechanisms have been hypothesized. The inflammatory response in vitiligo is thought to be mediated by polymorphism in genes such as FOXP3, ACE, APE, GSTP1, TLR, SOD, CTLA-4, TAP/LMP gene cluster, etc. Theories including reactive oxygen species model, Nrf2-antioxidant response element (ARE) pathway, WNT pathway, tyrosinase activity, biochemical, molecular, and cellular alterations have been hypothesized to explain vitiligo pathogenesis...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29196206/divergence-of-protein-sensing-tlr-4-5-and-nucleic-acid-sensing-tlr-3-7-within-the-reptilian-lineage
#10
Manisha Priyam, Mamta Tripathy, Umesh Rai, Soma Mondal Ghorai
No abstract text is available yet for this article.
November 28, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29195133/effects-of-fish-oils-on-ex-vivo-b-cell-responses-of-obese-subjects-upon-bcr-tlr-stimulation-a-pilot-study
#11
William Guesdon, Rasagna Kosaraju, Patricia Brophy, Angela Clark, Steve Dillingham, Shahnaz Aziz, Fiona Moyer, Kate Willson, James R Dick, Shivajirao Prakash Patil, Nicholas Balestrieri, Michael Armstrong, Nichole Reisdroph, Saame Raza Shaikh
The long-chain n-3 polyunsaturated fatty acids (LC-PUFAs) eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) in fish oil have immunomodulatory properties. B cells are a poorly studied target of EPA/DHA in humans. Therefore, in this pilot study, we tested how n-3 LC-PUFAs influence B-cell responses of obese humans. Obese men and women were assigned to consume four 1-g capsules per day of olive oil (OO, n=12), fish oil (FO, n=12) concentrate or high-DHA-FO concentrate (n=10) for 12 weeks in a parallel design...
November 2, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29193143/anti-inflammatory-and-anti-apoptotic-effects-of-the-combination-of-ligusticum-chuanxiong-and-radix-paeoniae-against-focal-cerebral-ischaemia-via-tlr4-myd88-mapk-nf-%C3%AE%C2%BAb-signalling-pathway-in-mcao-rats
#12
Junfei Gu, Shulan Su, Jianming Guo, Yue Zhu, Ming Zhao, Jin-Ao Duan
OBJECTIVE: This study was performed to assess the anti-inflammatory and anti-apoptotic effects of the combination of Ligusticum chuanxiong and Radix Paeoniae (XS) on focal cerebral ischaemic stroke. METHODS: MCAO rats were used to evaluate the effect of XS on stroke. Cerebral water content was measured, and the levels of IFN-γ, IL-1β, IL-6 and IL-12 in serum and brain were assessed by ELISA kits. Protein expressions including p-p38, p-38, TLR-4, p-ERK, ERK, TLR-5, NF-κBp65, Myd88, Caspase-3 and Caspase-12 were examined by WB and IHC...
November 28, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29192951/first-in-man-study-of-dedicated-bifurcation-cobalt-chromium-sirolimus-eluting-stent-bioss-lim-c-3-month-results
#13
Robert J Gil, Jacek Bil, Adam Kern, Tomasz Pawłowski
BACKGROUND: The optimal approach to coronary bifurcations treatment by PCI is still a subject of debate and the dedicated bifurcation stents are one of proposed solutions. AIM: The aim of this report was to assess effectiveness and safety profile of a new dedicated bifurcation stent - sirolimus-eluting BiOSS® LIM C (Balton, Poland) at the first 3 months of the 12-month Registry. METHODS: This is the two-center registry, which enrolls patients with NSTE-ACS and stable angina...
December 1, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29190881/toll-like-receptor-expression-in-human-non-small-cell-lung-carcinoma-potential-prognostic-indicators-of-disease
#14
Alison K Bauer, Brad L Upham, Elizabeth A Rondini, Meredith A Tennis, Kalpana Velmuragan, David Wiese
Introduction: Lung cancer remains the highest cause of cancer mortality worldwide. Toll-like receptors (TLR) are innate immune receptors that have both pro- and anti-tumorigenic properties. Based on findings from epidemiological studies and in rodents, we hypothesized that elevated TLR expression would be a positive prognostic indicator of disease in non-small cell lung carcinoma patients. Results: Higher mRNA expression of TLR1-3 and 5-8 were significantly associated with increased overall survival (OS) when analyzed individually or as a group in both non-small cell lung carcinoma (NSCLC) patients and in the adenocarcinoma (ADC) subtype...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29183810/identification-structural-characterization-and-expression-analysis-of-toll-like-receptors-2-and-3-from-gibel-carp-carassius-auratus-gibelio
#15
Yuding Fan, Yong Zhou, Lingbing Zeng, Nan Jiang, Wenzhi Liu, Jianqing Zhao, Qiwang Zhong
Toll-like receptors (TLRs) are important components of innate immunity. TLRs recognize pathogen-associated molecular patterns (PAMPs) and initiate downstream signaling pathways in response. In present study, we report the identification of two TLRs from gibel carp (Carassius auratus gibelio), TLR2 and TLR3 (designated CagTLR2 and CagTLR3, respectively). We report on the genomic structures and mRNA expression patterns of CagTLR2 and CagTLR3. Five exons and four introns were identified from the genomic DNA sequence of CagTLR3 (4749 bp in total length); this genomic organization is similar to that of TLR3 in zebrafish and human...
November 26, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29181004/identification-of-secretory-leukoprotease-inhibitor-as-an-endogenous-negative-regulator-in-allergic-effector-cells
#16
Shintaro Matsuba, Toshiki Yabe-Wada, Kazuya Takeda, Tetsuya Sato, Mikita Suyama, Toshiyuki Takai, Toshiaki Kikuchi, Toshihiro Nukiwa, Akira Nakamura
Mast cells, basophils, and eosinophils are central effectors in allergic inflammatory disorders. These cells secrete abundant serine proteases as well as chemical mediators and cytokines; however, the expression profiles and functions of their endogenous inhibitors remain elusive. We found that murine secretory leukoprotease inhibitor (SLPI) is expressed in basophils and eosinophils but in not in mast cells. SLPI-deficient (Slpi-/-) basophils produce more cytokines than wild-type mice after IgE stimulation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29171715/restenosis-patterns-after-bioresorbable-vascular-scaffold-implantation-angiographic-substudy-of-the-ghost-eu-registry
#17
Moritz Baquet, Holger Nef, Tomasso Gori, Azeem Latib, Davide Capodanno, Carlo Di Mario, Manel Sabate, Antonio Colombo, Corrado Tamburino, Julinda Mehilli
OBJECTIVES: To evaluate pattern of in-BVS-restenosis after bioresorbable vascular scaffold (BVS) implantation. BACKGROUND: In-stent restenosis morphology impacts target lesion revascularization (TLR) rates and clinical outcomes. Although several trials report on outcomes after BVS implantation, information about in-BVS restenosis pattern is still lacking. METHODS: Between November 2011 and January 2014, in 7 of 10 European centers participating in the GHOST-EU registry, 668 patients underwent BVS implantation...
November 24, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29168541/evaluation-of-bioresorbable-vascular-scaffolds-in-acute-coronary-syndrome-a-two-center-one-year-follow-up-analysis
#18
Sylwia Iwańczyk, Jarosław Hiczkiewicz, Aleksander Araszkiewicz, Magdalena Łanocha, Daria Adamczak, Wojciech Faron, Stefan Grajek, Maciej Lesiak
BACKGROUND: Bioresorbable vascular scaffolds (BVS) have emerged as a new treatment option in cardiovascular medicine. Nonetheless, there is still limited data on the use of these novel devices in patients with acute coronary syndromes (ACS). The purpose of this study was to evaluate the feasibility and efficacy of BVS implantation in patients with ACS. METHODS: The present report is a prospective, two-centre registry that involved 165 consecutive patients hospitalized with the diagnosis of ACS and treated with the Absorb BVS (Abbot Vascular, Santa Clara, USA)...
November 23, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29167614/thirty-day-and-one-year-clinical-outcomes-of-bioresorbable-vascular-scaffold-implantation-a-single-center-experience
#19
Wei-Chieh Lee, Chiung-Jen Wu, Chien-Jen Chen, Cheng-Hsu Yang, Shu-Kai Hsueh, Hon-Kan Yip, Chi-Ling Hang, Chih-Yuan Fang, Hsiu-Yu Fang
Background: Available data on the use of the Bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, CA) in real-world patients is limited, particularly in Asian populations. The aim of this study was to assess clinical outcomes of patients treated with a BVS in real-world practice in Taiwan. Methods: This study focused on 156 patients with coronary artery disease and a total of 249 lesions who received BVS implantation from October 2012 to October 2015...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29164710/expression-profiles-of-immunity-and-reproductive-genes-during-transition-period-in-holstein-cattle
#20
A I Ateya, M S Hussein, H M Ghanem, R M Saleh, W B El-Domany, Y Y Elseady
The transition period is a critical time for dairy cows as the animal is subjected to the physiological stress accompanying parturition. Immunosuppression and health status were examined during this period in 80 Holstein cows. Blood samples were taken from each cow 3, 2 and 1 week before and after calving, and at calving (0 day). RNA was extracted and subjected to real-time PCR to determine mRNA levels for the immune-related genes TLR 2, 4, 6, 7 and β-defensin 5 in addition to the reproduction-related genes prolactin and IGF-I...
November 21, 2017: Reproduction in Domestic Animals, Zuchthygiene
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