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https://www.readbyqxmd.com/read/29626115/macrophage-microglial-ezh2-facilitates-autoimmune-inflammation-through-inhibition-of-socs3
#1
Xingli Zhang, Yan Wang, Jia Yuan, Ni Li, Siyu Pei, Jing Xu, Xuan Luo, Chaoming Mao, Junli Liu, Tao Yu, Shucheng Gan, Qianqian Zheng, Yinming Liang, Weixiang Guo, Ju Qiu, Gabriela Constantin, Jin Jin, Jun Qin, Yichuan Xiao
Histone 3 Lys27 (H3K27) trimethyltransferase Ezh2 is implicated in the pathogenesis of autoimmune inflammation. Nevertheless, the role of Ezh2 in macrophage/microglial activation remains to be defined. In this study, we identified that macrophage/microglial H3K27me3 or Ezh2, rather than functioning as a repressor, mediates toll-like receptor (TLR)-induced proinflammatory gene expression, and therefore Ezh2 depletion diminishes macrophage/microglial activation and attenuates the autoimmune inflammation in dextran sulfate sodium-induced colitis and experimental autoimmune encephalomyelitis...
April 6, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29622449/one-year-clinical-outcome-of-biodegradable-polymer-sirolimus-eluting-stent-in-all-comers-population-insight-from-the-ulisse-registry-ultimaster-italian-multicenter-all-comers-stent-registry
#2
Cosmo Godino, Alessandro Beneduce, Giuseppe Ferrante, Alfonso Ielasi, Andrea Carlo Pivato, Mauro Chiarito, Alberto Cappelletti, Giulia Perfetti, Valeria Magni, Eugenio Prati, Stefania Falcone, Adele Pierri, Stefano De Martini, Matteo Montorfano, Rosario Parisi, David Rutigliano, Nicola Locuratolo, Angelo Anzuini, Maurizio Tespilli, Alberto Margonato, Alberto Benassi, Carlo Briguori, Franco Fabbiocchi, Bernhard Reimers, Antonio Bartorelli, Antonio Colombo
BACKGROUND: This study was designed to confirm in a large population of unselected patients the promising results of Ultimaster® biodegradable polymer sirolimus-eluting stent (BP-SES) already shown in previous trial. METHODS: ULISSE is an observational, multicenter, national registry evaluating all patients undergoing PCI with the Ultimaster® BP-SES. Incidence of 1-year TLF (cardiac death or target vessel MI or clinically indicated TLR) was the primary endpoint...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29615799/idelalisib-impairs-trem-1-mediated-neutrophil-inflammatory-responses
#3
Astrid Alflen, Nicole Stadler, Pamela Aranda Lopez, Daniel Teschner, Matthias Theobald, Georg Heß, Markus P Radsak
Triggering receptor expressed on myeloid cells (TREM)-1 on polymorphonuclear neutrophils (PMN) regulates innate immune activation in infectious and non-infectious conditions. TREM-1 ligation activates phosphatidyl-inositol 3 kinase (PI3K) triggering all neutrophil effector functions. As idelalisib is a PI3K inhibitor in clinical use for the treatment of non-Hodgkin lymphomas, we asked whether this inhibitor affects PMN functionalities. We analyzed PMNs from healthy donors or lymphoma patients for oxidative burst, phagocytosis, activation markers and IL-8 release upon TREM-1 or TLR ligation ex vivo...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29609129/nebulized-lidocaine-ameliorates-allergic-airway-inflammation-via-downregulation-of-tlr2
#4
Lixia Wang, Muzi Wang, Shuai Li, Huimei Wu, Qiying Shen, Shihai Zhang, Lei Fang, Rongyu Liu
Nebulized lidocaine has been suggested to be beneficial in asthma therapy, but the underlying mechanisms are little known. We aimed to investigate whether Toll-like receptor (TLR) 2 was involved in the protective effect of lidocaine on allergic airway inflammation. Female C57BL/6 mice were sensitized and challenged with ovalbumin (OVA). Meanwhile, some of the mice were treated with TLR2 agonist (Pam3CSK4, 100 μg) intraperitoneally in combination with OVA on day 0. Just after allergen provocation, mice were treated with inhaled lidocaine or vehicle for 30 min...
March 30, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29606967/effects-of-oregano-essential-oil-on-brain-tlr4-and-tlr2-gene-expression-and-depressive-like-behavior-in-a-rat-model
#5
Azam Amiresmaeili, Samira Roohollahi, Ali Mostafavi, Nayere Askari
The aim of the present study was to evaluate the effects of oregano essential oil (OEO) on the hippocampus and prefrontal cortex TLR 2/4 gene expression and depressive like behavior induced by chronic unpredictable stress (CUS). Sucrose preference and forced swim tests were adopted to examine the antidepressant effect. Control (CON), OEO, CUS, and CUS + OEO groups were used. The OEO and CUS + OEO groups received OEO (0.2 mL/kg, i.p.), CON and CUS received saline (0.2 mL/kg, i.p.), and the positive drug groups of CUS rats received fluoxetine (10 mg/kg) and diazepam (3 mg/kg) once daily for 14 days...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29605095/activated-renal-tubular-wnt-%C3%AE-catenin-signaling-triggers-renal-inflammation-during-overload-proteinuria
#6
Dickson W L Wong, Wai Han Yiu, Kam Wa Chan, Ye Li, Bin Li, Sarah W Y Lok, Makoto M Taketo, Peter Igarashi, Loretta Y Y Chan, Joseph C K Leung, Kar Neng Lai, Sydney C W Tang
Imbalance of Wnt/β-catenin signaling in renal cells is associated with renal dysfunction, yet the precise mechanism is poorly understood. Previously we observed activated Wnt/β-catenin signaling in renal tubules during proteinuric nephropathy with an unknown net effect. Therefore, to identify the definitive role of tubular Wnt/β-catenin, we generated a novel transgenic "Tubcat" mouse conditionally expressing stabilized β-catenin specifically in renal tubules following tamoxifen administration...
March 28, 2018: Kidney International
https://www.readbyqxmd.com/read/29603875/toll-like-receptor-2-and-3-enhance-melanogenesis-and-melanosome-transport-in-human-melanocytes
#7
AutSaaya Koike, Kenshi Yamasaki, Takeshi Yamauchi, Mai Inoue, Ryoko Shimada-Ohmori, Kenichiro Tsuchiyama, Setsuya Aiba
Because little is known about how the innate immune response influences skin pigmentation, we examined whether Toll-like receptor (TLR) agonists participate in melanogenesis and melanosome transportation. We observed that TLR2/2 agonist HKLM and TLR3 agonist Poly(I:C) increased the amount of extracellular melanin from primary human epidermal melanocytes. HKLM, but not Poly(I:C), increased the melanogenic genes such as tyrosinase and dopachrome tautomerase. Poly(I:C) increased the expression of Rab27A, a molecule that facilitates melanosome transport to perimembranous actin filament...
March 30, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29602972/the-potential-role-of-toll-like-receptor-4-asp299gly-polymorphism-and-its-association-with-recurrent-cystic-echinococcosis-in-postoperative-patients
#8
Jafar Noori, Adel Spotin, Ehsan Ahmadpour, Mahmoud Mahami-Oskouei, Homayoun Sadeghi-Bazargani, Tohid Kazemi, Ebrahim Sakhinia, Leili Aghebati-Maleki, Firooz Shahrivar
The study of pathogenesis mechanisms of larval stages in the Taeniidae has recently focused on host genetic factors, particularly toll-like receptor (TLR) variations. However, the potential role of TLR4 polymorphism in hydatidosis has not yet been sufficiently elucidated in postoperative patients. In this case-control investigation, 80 patients from Iran, including 40 with acute hydatidosis (AH) and 40 with recurrent hydatidosis (RH), and 80 ethnically matched controls were evaluated from February 2015 to February 2017...
March 30, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29602153/lymphocytic-choriomeningitis-virus-infection-of-dendritic-cells-interferes-with-tlr-induced-il-12-il-23-cytokine-production-in-an-il-10-independent-manner
#9
Nor Fazila Che Mat, Sarah Siddiqui, Divya Mehta, Kyle Seaver, Andra Banete, Torki Alothaimeen, Katrina Gee, Sameh Basta
Dendritic cells produce IL-12 and IL-23 in response to viral and bacterial infection and these cytokines are responsible for successful pathogen clearance. How sequential viral and bacterial infections affect the production of IL-12 and IL-23 is currently not known. Our study demonstrates that in dendritic cells infected with Lymphocytic choriomeningitis virus (LCMV), TLR activation with bacterial PAMPs resulted in reduced IL-12 and IL-23 expression compared to non-infected cells. Furthermore, expression of other proinflammatory cytokines, TNF-α and IL-6, were not inhibited under these conditions...
March 26, 2018: Cytokine
https://www.readbyqxmd.com/read/29593736/type-i-interferon-independent-dendritic-cell-priming-and-antitumor-t-cell-activation-induced-by-a-mycoplasma-fermentans-lipopeptide
#10
Yohei Takeda, Masahiro Azuma, Kenji Funami, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
Mycoplasma fermentans -derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) 2/TLR6. Short proteolytic products including macrophage-activating lipopeptide 2 (MALP2) have been utilized as antitumor immune-enhancing adjuvants. We have chemically synthesized a short form of MALP2 named MALP2s ( S -[2,3-bis(palmitoyloxy)propyl]-CGNNDE). MALP2 and MALP2s provoke natural killer (NK) cell activation in vitro but only poorly induce tumor regression using in vivo mouse models loading NK-sensitive tumors...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29589098/two-year-clinical-outcomes-of-the-consequent-trial-can-femoropopliteal-lesions-be-treated-with-sustainable-clinical-results-that-are-economically-sound
#11
Thomas Albrecht, Matthias Waliszewski, Catherine Roca, Ulf Redlich, Jörg Tautenhahn, Maciej Pech, Zuhir Halloul, Özlem Gögebakan, Dirk-Roelfs Meyer, Ines Gemeinhardt, Thomas Zeller, Stefan Müller-Hülsbeck, Ilka Ott, Gunnar Tepe
PURPOSE: The previously reported 6-month angiographic and 12-month clinical outcomes of the CONSEQUENT trial demonstrated the safety and efficacy of a novel paclitaxel-resveratrol-coated balloon for the treatment of lesions in the femoropopliteal segment. The purpose of this report is to present the 2-year results including a cost-benefit analysis for Germany. MATERIALS AND METHODS: Patients with symptomatic peripheral artery occlusive disease in femoropopliteal lesions were randomized either to drug-coated balloon (DCB, n = 78) or plain old balloon angioplasty (POBA, n = 75)...
March 27, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29583049/role-of-toll-like-receptor-4-and-caspase-3-8-and-9-in-lipopolysaccharide-induced-delay-of-apoptosis-in-equine-neutrophils
#12
Stacy L Anderson, Hugh G G Townsend, Baljit Singh
OBJECTIVE To evaluate the effect of lipopolysaccharide (LPS) on apoptosis of equine neutrophils in vitro. SAMPLE Venous blood samples from 40 adult horses. PROCEDURES Neutrophils were isolated from blood samples and cultured with or without LPS from Escherichia coli O55:B5 for 12 or 24 hours. Neutrophil apoptosis was assessed by use of cytologic examination, annexin V and propidium iodide staining quantified with flow cytometry, coincubation with inducers of intrinsic and extrinsic apoptosis or a toll-like receptor (TLR) 4 inhibitor, and measurement of caspase-3, -8, and -9 activities...
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29582430/human-periodontal-ligament-cells-exhibit-no-endotoxin-tolerance-upon-stimulation-with-porphyromonas-gingivalis-lipopolysaccharide
#13
A Blufstein, C Behm, P Q Nguyen, X Rausch-Fan, O Andrukhov
BACKGROUND/OBJECTIVES: Endotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endotoxins such as lipopolysaccharides (LPS) at low concentrations. The aim of this study was to investigate, whether pretreatment with Porphyromonas gingivalis leads to endotoxin tolerance induction and possible alterations in toll-like receptor (TLR) 2- and 4-induced response in human periodontal ligament cells (hPDLCs). MATERIAL AND METHODS: Primary hPDLCs were pretreated with P...
March 26, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29577815/the-efficacy-of-drug-eluting-stent-for-recurrent-central-venous-restenosis-in-a-patient-undergoing-hemodialysis
#14
Sadanori Shintaku, Tomoyasu Sato, Hideki Kawanishi, Misaki Moriishi, Shinichiro Tsuchiya
INTRODUCTION: Recurrent central venous restenosis is problematic in patients with ipsilateral arteriovenous fistula. We report our experience using a drug-eluting stent for the treatment of recurrent central vein restenosis. CASE REPORT: A 60-year-old man consulted our hospital because of recurrent swelling of his left upper limb with radial-cephalic arteriovenous fistula that originated in the distal forearm. More than 3 years prior, two bare-metal stents were placed for the obstructed lesions in the left subclavian and brachiocephalic venous lesions, and repeated balloon angioplasty for recurrent in-stent stenosis was performed approximately every 3 months...
March 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29571972/immunoinformatics-approaches-to-design-a-novel-multi-epitope-subunit-vaccine-against-hiv-infection
#15
Rajan Kumar Pandey, Rupal Ojha, Veeranarayanan Surya Aathmanathan, Muthukalingan Krishnan, Vijay Kumar Prajapati
The end goal of HIV vaccine designing requires novel strategies to elicit a strong humoral and cell-mediated immune response. The emergence of drug resistance and the requirement of next line treatment necessitate the finding of the potential and immunogenic vaccine candidate. This study employed a novel immunoinformatics approach to design multi-epitope subunit vaccine against HIV infection. Here, we designed the subunit vaccine by the combination of CTL, HTL and BCL epitopes along with suitable adjuvant and linkers...
March 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29571731/hmgb1-mediates-hadv-7-infection-induced-pulmonary-inflammation-in-mice
#16
Zhengzhen Tang, Na Zang, Yangxi Fu, Zhixu Ye, Sisi Chen, Shi Mo, Luo Ren, Enmei Liu
Human adenovirus (HAdV) is a common respiratory pathogen in children, with no safe and effective treatment currently available. HAdV type 7 (HAdV-7), in particular, causes severe pediatric pneumonia with a high incidence of sequelae and mortality. Clinical data and animal experiments suggest that HAdV-7-induced pneumonia promotes cell necrosis, releasing a large number of inflammatory mediators. In recent years, the high mobility group box-1 (HMGB1) protein, released by necrotic cells, has been shown to play important roles in several viral infections...
March 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29570768/tim-3-exacerbates-kidney-ischemia-reperfusion-injury-through-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-and-an-nlrc4-inflammasome-activation
#17
Yunshan Guo, Jing Zhang, Xingqiang Lai, Miaojuan Chen, Yunshan Guo
T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) as a member of immunoglobulin superfamily, has been shown to play a crucial role in host adaptive immunity and tolerance. However, its role in kidney ischemia-reperfusion injury (IRI) remains unknown. In this study, we investigated the role and mechanism of Tim-3 signaling after kidney IRI. In an established murine model of kidney IRI, we found that Tim-3 expression is enhanced on monocytes/macrophages. Anti-Tim-3 Ab RMT3-23 ameliorates biochemical and histologic kidney injury, reduces apoptosis, decreases macrophage infiltration and cytokine production in ischemic kidneys...
March 23, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29568891/tissue-expression-of-toll-like-receptors-2-3-4-and-7-in-swine-in-response-to-the-shimen-strain-of-classical-swine-fever-virus
#18
Zhi Cao, Minping Zheng, Huifang Lv, Kangkang Guo, Yanming Zhang
The Toll-like receptors (TLRs) of the innate immune system provide the host with the ability to detect and respond to viral infections. The present study aimed to investigate the mRNA and protein expression levels of TLR2, 3, 4 and 7 in porcine tissues upon infection with the highly virulent Shimen strain of classical swine fever virus (CSFV). Reverse transcription‑quantitative polymerase chain reaction was used to detect the mRNA expression levels of CSFV and TLR, whereas western blotting was used to detect the expression levels of TLR proteins...
March 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29560427/deficiency-of-toll-like-receptors-2-3-or-4-extends-life-expectancy-in-huntington-s-disease-mice
#19
Kathleen Griffioen, Mark P Mattson, Eitan Okun
Huntington's disease (HD), an autosomal dominant neurodegenerative disorder characterized by progressive striatal and cortical atrophy, has been strongly linked with neuroinflammation. Toll-like receptors, a family of innate immune receptors, are a major pathway for neuroinflammation with pleiotropic effects on neuronal plasticity and neurodevelopment. We assessed whether deficiency for TLRs 2, 3 or 4 affects life expectancy in the N171-82Q mouse model of HD. Our data indicate that homozygous TLRs 2 and 3 as well as heterozygous TLR4 deficiency significantly extends the life expectancy of HD mice...
January 2018: Heliyon
https://www.readbyqxmd.com/read/29559671/infant-anemia-is-associated-with-reduced-tlr-stimulated-cytokine-responses-and-increased-nasopharyngeal-colonization-with-moxarella-catarrhalis
#20
Sui-Ling Liao, Shih-Yun Hsu, Shen-Hao Lai, Shih-Hsiang Chen, Man-Chin Hua, Tsung-Chieh Yao, Li-Chen Chen, Ming-Han Tsai, Jing-Long Huang
Anemia is a major public health problem in young children. Reports on the role of anemia on infectious diseases remained controversial. We aim to investigate the effect of anemia on innate immunity, nasopharyngeal bacterial colonization, and subsequent infectious outcome. Blood tests were examined at the age of 12 months. TLR-induced cytokine production was assessed by ELISA. Bacteria from nasopharyngeal specimens were identified with traditional culture. Clinical infectious diseases were followed yearly until 3 years of age...
March 20, 2018: Scientific Reports
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