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https://www.readbyqxmd.com/read/29352372/improving-pet-quantification-of-small-animal-68ga-dota-labeled-pet-ct-studies-by-using-a-ct-based-positron-range-correction
#1
Jacobo Cal-Gonzalez, Juan José Vaquero, Joaquín L Herraiz, Mailyn Pérez-Liva, María Luisa Soto-Montenegro, Santiago Peña-Zalbidea, Manuel Desco, José Manuel Udías
PURPOSE: Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [68Ga]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC)...
January 19, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29351447/cigarette-smoke-dampens-anti-viral-signaling-in-small-airway-epithelial-cells-by-disrupting-tlr3-cleavage
#2
Parker F Duffney, Claire E McCarthy, Aitor Nogales, Thomas H Thatcher, Luis Martinez-Sobrido, Richard P Phipps, Patricia J Sime
Cigarette smokers and people exposed to secondhand smoke are at an increased risk for pulmonary viral infections, yet the mechanism responsible for this heightened susceptibility is not understood. To understand the effect of cigarette smoke on susceptibility to viral infection we used an air-liquid interface culture system, and exposed primary human small airway epithelial cells (SAEC) to whole cigarette smoke followed by treatment with the viral mimetic polyinosinic polycytidylic acid (poly I:C) or influenza A virus (IAV)...
December 14, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29345364/the-n-terminal-peptide-moiety-of-the-mycobacterium-tuberculosis-19-kda-lipoprotein-harbors-rp105-agonistic-properties
#3
Thomas E Schultz, Karl-Heinz Wiesmüller, Megan Lucas, Karen M Dobos, Alan G Baxter, Antje Blumenthal
Radioprotective 105 kDa (RP105, CD180) is a member of the Toll-like receptor (TLR) family that interacts with TLR2 and facilitates recognition of mature lipoproteins expressed by Mycobacterium tuberculosis and Mycobacterium bovis BCG. In this study, we used synthetic lipopeptide analogs of the M. tuberculosis 19 kDa lipoprotein to define structural characteristics that promote RP105-mediated host cell responses. A tripalmitoylated lipopeptide composed of the first 16 N-terminal amino acids of the M. tuberculosis 19 kDa lipoprotein induced RP105-dependent TNF and IL-6 production by macrophages...
January 9, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29344995/activation-of-human-cd141-and-cd1c-dendritic-cells-in-vivo-with-combined-tlr-3-and-tlr-7-8-ligation
#4
Frances E Pearson, Karshing Chang, Yoshihito Minoda, Ingrid M Leal Rojas, Oscar L Haigh, Ghazal Daraj, Kirsteen M Tullett, Kristen J Radford
Mice reconstituted with human hematopoietic stem cells are valuable models to study aspects of the human immune system in vivo. We describe a humanized mouse model (hu mice) in which fully functional human CD141+ and CD1c+ myeloid and CD123+ plasmacytoid dendritic cells (DC) develop from human cord blood CD34+ cells in immunodeficient mice. CD141+ DC are the human equivalents of murine CD8+ /CD103+ DC which are essential for the induction of tumor-inhibitory cytotoxic T lymphocyte (CTL) responses, making them attractive targets to exploit for the development of new cancer immunotherapies...
January 18, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29342502/antiphospholipid-antibodies-inhibit-trophoblast-toll-like-receptor-and-inflammasome-negative-regulators
#5
Melissa J Mulla, Ingrid C Weel, Julie A Potter, Stefan M Gysler, Jane E Salmon, Maria T S Peraçoli, Carla V Rothlin, Lawrence W Chamley, Vikki M Abrahams
OBJECTIVE: Women with antiphospholipid antibodies (aPL) are at risk for pregnancy complications associated with poor placentation and placental inflammation. While these antibodies are heterogeneous, some anti-β2 GPI antibodies can activate human first trimester trophoblast TLR4 and NLRP3. The objective of this study was to determine the role of negative regulators of TLR and inflammasome function in aPL-induced trophoblast inflammation. METHODS: Human trophoblast cells were treated with or without anti-β2 GPI aPL or control IgG in the presence or absence of the common TAM receptor ligand, GAS6, or the autophagy inducer, rapamycin...
January 17, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29338314/inflammatory-cytokines-in-the-papillary-tips-and-urine-of-nephrolithiasis-patients
#6
Andrew Yang Sun, Bryan Hinck, Benjamin R Cohen, Karen Keslar, Robert L Fairchild, Manoj Monga
INTRODUCTION: Intrarenal inflammation has been implicated in the pathogenesis of nephrolithiasis, with prior work showing increased urine levels of IL-6, IL-8, and CCL-2 in stone patients. However, no studies have assessed for inflammation in the renal papillae. We sought to characterize novel papillary tip and urinary biomarkers in stone patients. METHODS: 92 patients with nephrolithiasis undergoing percutaneous nephrolithotomy were enrolled. Papillary tip biopsies, kidney urine, and bladder urine were collected, as well as voided urine from 8 healthy volunteers...
January 16, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29331320/zika-dengue-and-yellow-fever-viruses-induce-differential-anti-viral-immune-responses-in-human-monocytic-and-first-trimester-trophoblast-cells
#7
Huanle Luo, Evandro R Winkelmann, Ildefonso Fernandez-Salas, Li Li, Sandra V Mayer, Rogelio Daniz-Lozano, Rosa Ma Sanchez-Casas, Nikos Vasilakis, Robert Tesh, Alan D Barrett, Scott C Weaver, Tian Wang
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the same species of mosquitoes. However, YFV and DENV have been rarely reported to cause congenital diseases. Here, we compared infection with a contemporary ZIKV strain (FSS13025) to YFV17D and DENV-4 in human monocytic cells (THP-1) and first-trimester trophoblasts (HTR-8)...
January 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29330675/recognizing-conserved-non-canonical-localization-patterns-of-toll-like-receptors-in-tissues-and-across-species
#8
REVIEW
Glenn Hamonic, J Alex Pasternak, Heather L Wilson
Toll-like receptors (TLR) 1, 2, 4, 5 and 6 were originally characterized as exclusively expressed on the cell surface and TLR 3, 7, 8 and 9 were said to be localized to the endosomes. However, continued research in this area shows that TLR localization may be altered across cell-types, and in response to stimulation, age or disease. Mucosal surfaces must remain tolerant to the commensal flora and thus intracellular or basal lateral localization of TLRs at mucosal surfaces may be necessary to prevent induction of an inflammatory response to commensal flora while still allowing the possibility for the receptors to prime an immune response when a pathogen has crossed the epithelial barrier...
January 12, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29329218/molecular-and-physiological-effects-on-the-small-intestine-of-weaner-pigs-following-feeding-with-deoxynivalenol-contaminated-feed
#9
J Alex Pasternak, Vaishnavi Iyer Aka Aiyer, Glenn Hamonic, A Denise Beaulieu, Daniel A Columbus, Heather L Wilson
We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets were fed traditional Phase I, Phase II and Phase III diets with the control group receiving 0.20-0.40 ppm DON (referred to as the Control group) and treatment group receiving much higher level of DON-contaminated wheat (3.30-3.80 ppm; referred to as DON-contaminated group). Feeding a DON-contaminated diet had no impact on average daily feed intake (ADFI) (p < 0...
January 12, 2018: Toxins
https://www.readbyqxmd.com/read/29325294/-effects-of-lactobacillus-paracasei-n1115-combined-with-fructooligosaccharides-on-non-alcoholic-fatty-liver-disease-induced-by-high-fat-diet-in-mice
#10
F F Yao, P Y Zheng, H Huang, L M Bai, Y R Ding, L Mei, S M Liu
Objective: To investigate the effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides (FOS) on non-alcoholic fatty liver disease (NAFLD) in mice and its possible mechanism. Methods: A total of 50 male C57 mice were randomly and equally divided into five experimental groups. Group 1 received a normal diet (ND). Other four groups received a high-fat diet (HFD) to establish NAFLD models. In addition to HFD, group 3 received Lactobacillus paracasei N1115 (2.2×10(9) CFU/mL), group 4 received FOS (4 g/kg per day), and group 5 received Lactobacillus paracasei N1115 (2...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29313272/tenascin-c-a-biomarker-of-disease-activity-in-early-ankylosing-spondylitis
#11
Latika Gupta, Shruti Bhattacharya, Amita Aggarwal
Monocytes of patients with ankylosing spondylitis (AS) over-express toll-like receptor (TLR) 4. Tenascin-C (TNC) is an endogenous TLR4 ligand. Thus, we studied the serum and synovial fluid levels of TNC in AS. TNC was measured in serum of 36 AS patients (ASAS 2010 criteria) and 39 healthy controls by ELISA. Twenty-two patients were followed up after 3 months of standard treatment. Five paired serum-synovial fluid samples were also analyzed. Disease activity was assessed by BASDAI, ASDAS, swollen joint count, ESR, and CRP...
January 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29303613/cellular-differentiation-of-non-transformed-intestinal-epithelial-cells-is-regulated-by-lactobacillus-rhamnosus-and-l-casei-strains
#12
J Kolinska, M Zakostelecka, Z Zemanova, V Lisa, J Golias, H Kozakova, B Dvorak
The aim of this study was to characterize an in vitro modulating effect of three commensal Lactobacillus strains on cellular differentiation of non-transformed crypt-like rat small intestinal cell line IEC-18. IEC-18 was grown on extracellular matrix (ECM), with or without presence of Lactobacillus strains. Gene expression of IEC-18 bacterial detection system - such as Toll-like receptors TLR-2, TLR-4, signal adapter MyD88, cytoplasmic NOD2 receptor, inflammatory cytokines IL-18, IL-1beta, chemokine IL-8 and enzyme caspase-1 - was evaluated using real-time PCR...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29302765/anti-inflammatory-effect-of-dna-polymeric-molecules-in-a-cell-model-of-osteoarthritis
#13
Ahreum Baek, MinGi Kim, Sung Hoon Kim, Sung-Rae Cho, Hyun Jung Kim
The DNA polymeric molecules polydeoxynucleotide (PDRN) and polynucleotide (PN) can be used as new alternative treatment for osteoarthritis (OA); however, the underlying mechanisms are not fully understood. In this study, we investigated the effect of PDRN and PN on gene-expression profiles in a cell model of OA using transcriptome analysis. Under hypoxic conditions, human chondrosarcoma cells were stressed for 24 h in the presence of interleukin (IL)-1β and subsequently treated with PDRN, PN, or hyaluronic acid (HA) for another 24 h, followed by transcriptome analysis...
January 4, 2018: Inflammation
https://www.readbyqxmd.com/read/29289655/construction-immune-protection-and-innate-immune-response-of-shuffled-polyvalent-ompas-vaccines
#14
Sheng-Nan Wang, Zhi-Xue Cheng, Xiao-Peng Ling, Xiao Chu, Xuan-Xian Peng, Hui Li
Our previous studies demonstrated that molecular breeding via DNA shuffling directs the evolution of polyvalent vaccines with desired traits, which leads to generation of polyvalent ompA vaccines using Vibrio alginolyticus VA0764 primers. Here, we replaced VA0764 primers with Edwardsiella tarda ompA primers to generate new polyvalent ompA vaccines by DNA shuffling of the same five ompA genes from four species of bacteria E. tarda, V. parahaemolyticus, V. alginolyticus and Escherichia coli. We identified four polyvalent vaccine candidates from a eukaryotic expressing library EompAs-FE containing 82 ompAs using active immune protection against V...
December 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29285955/novel-nitinol-stent-for-lesions-up-to-24-cm-in-the-superficial-femoral-and-proximal-popliteal-arteries-24-month-results-from-the-tigris-randomized-trial
#15
John R Laird, Thomas Zeller, Christian Loewe, Jack Chamberlin, Richard Begg, Peter A Schneider, Aravinda Nanjundappa, Frank Bunch, Scott Schultz, Stuart Harlin, Alexandra Lansky, Michael R Jaff
PURPOSE: To evaluate the safety and effectiveness of the TIGRIS stent for lesions up to 24 cm in the superficial femoral and proximal popliteal arteries (SFA/PPA). METHODS: This prospective, multicenter, randomized study enrolled 274 subjects at 36 sites in the United States and Europe. Subjects were randomly assigned in a 3:1 ratio to treatment with the TIGRIS stent (n=197; mean age 66.7±9.28 years; 141 men) or LifeStent (n=70; mean age 67.9±8.87 years; 49 men)...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29278354/long-term-clinical-outcomes-of-a-crystalline-sirolimus-eluting-coronary-stent-with-a-fully-bioabsorbable-polymer-coating-five-year-outcomes-from-the-dessolve-i-and-ii-trials
#16
William Wijns, Mathias Vrolix, Stefan Verheye, Danny Schoors, Ton Slagboom, Marcel Gosselink, Edouard Benit, David Kandzari, Dennis Donohoe, John A Ormiston
AIMS: The aim was to evaluate the five-year clinical results of a sirolimus-eluting stent (MiStent SES) with a bioabsorbable coating designed for sustained drug delivery during and after rapid polymer dissolution. METHODS AND RESULTS: The five-year results from the DESSOLVE I and II trials including major adverse cardiac events (MACE), target lesion failure (TLF), target vessel failure (TVF), and stent thrombosis (ST) at five-year follow-up are reported. In DESSOLVE I, 10...
December 26, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29262324/caspase-1-engagement-and-tlr-induced-c-flip-expression-suppress-asc-caspase-8-dependent-apoptosis-by-inflammasome-sensors-nlrp1b-and-nlrc4
#17
Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H V Saavedra, Nathalia M de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D'Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC. Here, we show that NLRP1b and NLRC4 trigger caspase-8-mediated apoptosis as an alternative cell death program in caspase-1-/- macrophages and intestinal epithelial organoids (IECs). The caspase-8 adaptor FADD was recruited to ASC specks, which served as cytosolic platforms for caspase-8 activation and NLRP1b/NLRC4-induced apoptosis...
December 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/29251204/directional-atherectomy-with-antirestenotic-therapy-vs-drug-coated-balloon-angioplasty-alone-for-common-femoral-artery-atherosclerotic-disease
#18
Konstantinos Stavroulakis, Arne Schwindt, Giovanni Torsello, Efthymios Beropoulis, Arne Stachmann, Christiane Hericks, Leonie Bollenberg, Theodosios Bisdas
PURPOSE: To report an experience using directional atherectomy (DA) with antirestenotic therapy (DAART) in the form of drug-coated balloon (DCB) angioplasty vs DCB angioplasty alone in common femoral artery (CFA) occlusive lesions. METHODS: A retrospective review was conducted of 47 consecutive patients (mean age 71 years; 26 men) treated between October 2011 and July 2016 using either DCB angioplasty alone (n=26) or DAART (n=21) for CFA lesions. The majority of patients had lifestyle-limiting claudication (14 DCB and 15 DAART)...
February 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29241180/high-mobility-group-box1-inhibitor-glycyrrhizic-acid-attenuates-kidney-injury-in-streptozotocin-induced-diabetic-rats
#19
Hong Zhang, Ru Zhang, Juan Chen, Min Shi, Wei Li, Xiangcheng Zhang
BACKGROUND/AIMS: High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and mechanisms of an HMGB1 inhibitor, glycyrrhizic acid (GA), in renal injury with the streptozotocin (STZ)-induced rat model. METHODS: The diabetic rat was generated by intraperitoneal injection of STZ and then treated with the HMGB1 inhibitor GA or saline for 8 weeks...
November 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29240962/long-term-outcomes-after-percutaneous-revascularization-of-complex-coronary-bifurcation-lesions-using-a-dedicated-self-expanding-biolimus-eluting-stent-system
#20
Andreas S Triantafyllis, Johan Bennett, Efstathios Pagourelias, Keir McCutcheon, Tom Adriaenssens, Peter R Sinnaeve, Walter Desmet, Christophe Dubois
BACKGROUND: To evaluate long-term clinical outcomes after treatment of complex bifurcation lesions with the AXXESS dedicated self-expanding biolimus A9-eluting bifurcation stent. METHODS: Between 2004 and 2013, 123 patients with complex bifurcation lesions were treated in a single center with the AXXESS stent in the proximal main vessel (MV) and additional drug-eluting stents in branches when required. Median follow-up was 5 years. Primary endpoint was the rate of major adverse cardiac events (MACE)...
December 14, 2017: Cardiology Journal
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