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https://www.readbyqxmd.com/read/29779267/%C3%AE-synuclein-activates-innate-immunity-but-suppresses-interferon-%C3%AE-expression-in-murine-astrocytes
#1
Jintang Wang, Zheng Chen, Jeremy Walston, Peisong Gao, Maolong Gao, Sean X Leng
Glial activation and neuroinflammation contribute to pathogenesis of neurodegenerative diseases, linked to neuron loss and dysfunction. α-Synuclein (α-syn), as a metabolite of neuron, can induce microglia activation to trigger innate immune response. However, whether α-syn, as well as its mutants (A53T, A30P and E46K), induces astrocyte activation and inflammatory response is not fully elucidated. In this study, we used A53T mutant and wildtype α-syns to stimulate primary astrocytes in dose- and time-dependent manners (0...
May 19, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29767328/a-placebo-controlled-efficacy-study-of-the-intravesical-immunomodulators-tmx-101-and-tmx-202-in-an-orthotopic-bladder-cancer-rat-model
#2
Johannes Falke, Christina A Hulsbergen-van de Kaa, Roberto Maj, Egbert Oosterwijk, J Alfred Witjes
PURPOSE: TMX-101 and TMX-202 are formulations of toll-like receptor 7 (TLR-7) agonists, under investigation for the treatment of urothelial carcinoma. Our goal was to evaluate the efficacy of intravesical instillations of TMX-101 or TMX-202 in an orthotopic bladder cancer rat model. METHODS: Four groups of 14 rats received an instillation with isogenic AY-27 tumor cells on day 0, starting tumor development. On day 2 and 5, the rats were treated with an intravesical instillation of TMX-101 0...
May 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29762247/lymph-node-with-the-highest-fdg-uptake-predicts-distant-metastasis-free-survival-in-patients-with-locally-advanced-nasopharyngeal-carcinoma
#3
Hojin Cho, Sung Hoon Kim, Hyunjeong Kim, Yoon Woo Koh, Se-Heon Kim, Eun Chang Choi, Mijin Yun
PURPOSE: Distant failure is a major concern in patients with nasopharyngeal carcinoma. We evaluated whether the metabolic features on 18F-FDG PET/CT can predict distant metastasis-free survival (DMFS) in patients with locally advanced nasopharyngeal carcinoma. METHODS: We retrospectively reviewed 51 patients stage III, IVA, and IVB nasopharyngeal carcinoma who underwent 18F-FDG PET/CT at staging. The SUVmax for the primary site and the lymph nodes with the highest uptake as well as at the farthest station were divided by the SUVmean of the background liver (TLR, NLR-H, and NLR-F, respectively)...
May 14, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29755453/clec10a-is-a-specific-marker-for-human-cd1c-dendritic-cells-and-enhances-their-toll-like-receptor-7-8-induced-cytokine-secretion
#4
Lukas Heger, Silke Balk, Jennifer J Lühr, Gordon F Heidkamp, Christian H K Lehmann, Lukas Hatscher, Ariawan Purbojo, Arndt Hartmann, Fayna Garcia-Martin, Shin-Ichiro Nishimura, Robert Cesnjevar, Falk Nimmerjahn, Diana Dudziak
Dendritic cells (DCs) are major players for the induction of immune responses. Apart from plasmacytoid DCs (pDCs), human DCs can be categorized into two types of conventional DCs: CD141+ DCs (cDC1) and CD1c+ DCs (cDC2). Defining uniquely expressed surface markers on human immune cells is not only important for the identification of DC subpopulations but also a prerequisite for harnessing the DC subset-specific potential in immunomodulatory approaches, such as antibody-mediated antigen targeting. Although others identified CLEC9A as a specific endocytic receptor for CD141+ DCs, such a receptor for CD1c+ DCs has not been discovered, yet...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29747237/treponema-denticola-chymotrypsin-like-proteinase-is-present-in-early-stage-mobile-tongue-squamous-cell-carcinoma-and-related-to-the-clinicopathological-features
#5
Dyah Listyarifah, Mikko T Nieminen, Laura K Mäkinen, Caj Haglund, Daniel Grenier, Valtteri Häyry, Dan Nordström, Marcela Hernandez, Tülay Yucel-Lindberg, Taina Tervahartiala, Mari Ainola, Timo Sorsa, Jaana Hagström
BACKGROUND: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. However the role of Td in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of Td-CTLP in early-stage mobile tongue squamous cell carcinoma (MTSCC) and its relation to clinical and pathological characteristics...
May 10, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29742464/gastrointestinal-microbiota-and-mucosal-immune-gene-expression-in-neonatal-pigs-reared-in-a-cross-fostering-model
#6
Nidia Maradiaga, Brian Aldridge, Mohamed Zeineldin, James Lowe
Cross fostering is employed to equalize the number of piglet between litters ensuring colostrum intake for their survival and growth. However, little is known about the impact of cross fostering on the intestinal microbiota and mucosal immune gene expression of the neonatal pig. The objective of this study was to determine the influence of maternal microbial communities on the gastrointestinal (GI) microbiota and mucosal immune gene expression in young pigs reared in a cross-fostering model. Piglets were given high quality colostrum from birth dam or foster dam upon birth...
May 6, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29723847/epigallocatechin-3-gallate-regulates-anti-inflammatory-action-through-67-kda-laminin-receptor-mediated-tollip-signaling-induction-in-lipopolysaccharide-stimulated-human-intestinal-epithelial-cells
#7
Eui-Baek Byun, Woo Sik Kim, Nak-Yun Sung, Eui-Hong Byun
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) is a condition that involves chronic inflammation in all or part of the digestive tract. Often painful and debilitating, IBD can lead to life-threatening complications and increase the risk for colon cancer. In this study, we investigated the epigallocatechin-3-gallate (EGCG) mediated anti-inflammation response in lipopolysaccharide (LPS)-stimulated human colorectal cells through the negative regulator of Toll-like receptor (TLR) signaling...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29722563/damage-associated-molecular-patterns-damps-in-resuscitated-hemorrhagic-shock-are-mitigated-by-peritoneal-fluid-administration
#8
Paul J Matheson, Mark A Eid, Matthew A Wilson, Victoria S Graham, Samuel A Matheson, Jessica Lee Weaver, Cynthia D Downard, Jason W Smith
INTRODUCTION: Conventional resuscitation (CR) of hemorrhagic shock (HS), a significant cause of trauma mortality, is I.V. blood and fluids. CR restores central hemodynamics, but vital organ flow can drop causing hypoperfusion, hypoxia, Damage-Associated Molecular Patterns (DAMPs), and remote organ dysfunction (i.e., lung). CR plus Direct Peritoneal Resuscitation (DPR) prevents intestinal and hepatic hypoperfusion. We hypothesized that DPR prevents lung injury in HS/CR by altering DAMPs...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29720034/peptidoglycan-and-lipoteichoic-acid-induces-differential-mrna-response-of-immune-related-genes-in-pbmc-of-crossbred-tharparkar-cattle-and-murrah-buffalo
#9
Sourabh Sulabh, Manjit Panigrahi, Sheikh Firdous Ahmad, Rajat Varshney, Ankita Verma, Naseer Ahmad Baba, Satish Kumar, Soni Kumari, Anuj Chauhan, Pushpendra Kumar, Bharat Bhushan
Subclinical mastitis, generally caused by Staphylococcus aureus, has a global economic impact all over the world. Hence, it needs to be resolved on higher priority which may be attained via. selection of mastitis resistant animals or inclusion of mastitis resistant trait into herd apart from management care. Diverse hosts with various genetic make-ups encounter pathogens in a diverse manner which in turn leads to contradicting outcome of the disease. Identification of species-wise or breed-wise differential expressed genes in response to S...
May 2, 2018: Animal Biotechnology
https://www.readbyqxmd.com/read/29717111/low-doses-of-lps-exacerbate-the-inflammatory-response-and-trigger-death-on-tlr3-primed-human-monocytes
#10
Marta Monguió-Tortajada, Marcella Franquesa, Maria-Rosa Sarrias, Francesc E Borràs
TLR sensing of pathogens triggers monocyte activation to initiate the host innate immune response to infection. Monocytes can dynamically adapt to different TLR agonists inducing different patterns of inflammatory response, and the sequence of exposure to TLRs can dramatically modulate cell activation. Understanding the interactions between TLR signalling that lead to synergy, priming and tolerance to TLR agonists may help explain how prior infections and inflammatory conditioning can regulate the innate immune response to subsequent infections...
May 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29715306/pentoxifylline-dexamethasone-and-azithromycin-demonstrate-distinct-age-dependent-and-synergistic-inhibition-of-tlr-and-inflammasome-mediated-cytokine-production-in-human-newborn-and-adult-blood-in-vitro
#11
Esther M Speer, David J Dowling, Jianjin Xu, Lukasz S Ozog, Jaime A Mathew, Avinash Chander, Donglei Yin, Ofer Levy
INTRODUCTION: Neonatal inflammation, mediated in part through Toll-like receptor (TLR) and inflammasome signaling, contributes to adverse outcomes including organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which potently suppresses cytokine production in newborn cord blood, is a candidate neonatal anti-inflammatory agent. We hypothesized that combinations of PTX with other anti-inflammatory agents, the steroid dexamethasone (DEX) or the macrolide azithromycin (AZI), may exert broader, more profound and/or synergistic anti-inflammatory activity towards neonatal TLR- and inflammasome-mediated cytokine production...
2018: PloS One
https://www.readbyqxmd.com/read/29708510/tumor-secreted-pros1-inhibits-macrophage-m1-polarization-to-reduce-antitumor-immune-response
#12
Eric Ubil, Laura Caskey, Alisha Holtzhausen, Debra Hunter, Charlotte Story, H Shelton Earp
Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In contrast, tumor cells with CRISPR-based deletion of Pros1 failed to inhibit M1 polarization. Tumor cell-associated Pros1 action was abrogated in macrophages from Mer- and Tyro3- but not Axl-KO mice. In addition, several other murine and human tumor cell lines suppressed macrophage M1 cytokine expression induced by IFN-γ and LPS...
April 30, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29702280/crosstalk-between-toll-like-receptor-3-and-notch-signaling-contributes-to-cd14-monocytes-activity-in-enterovirus-71-infected-hand-foot-and-mouth-disease
#13
Jie Hao, Peiling Li, Yunjiao Tian, Yanhua Wang, Suqing Li, Lina Wang, Shujun Li
Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate the crosstalk between TLR and Notch in inflammatory regulation in EV71 infection. Thirty-seven EV-71-indcued HFMD (16 mild and 21 severe cases) and eleven normal control (NC) were enrolled. CD14+ monocytes were purified, and were stimulated with either TLR3/4 agonists [poly(I: C) or LPS] or Notch signaling inhibitor...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29702142/dual-tlr-agonist-nanodiscs-as-a-strong-adjuvant-system-for-vaccines-and-immunotherapy
#14
Rui Kuai, Xiaoqi Sun, Wenmin Yuan, Lukasz J Ochyl, Yao Xu, Alireza Hassani Najafabadi, Lindsay Scheetz, Min-Zhi Yu, Ishina Balwani, Anna Schwendeman, James J Moon
Recent studies have shown that certain combinations of Toll-like receptor (TLR) agonists can induce synergistic immune activation. However, it remains challenging to achieve such robust responses in vivo in a manner that is effective, facile, and amenable for clinical translation. Here, we show that MPLA, a TLR4 agonist, and CpG, a TLR9 agonist, can be efficiently co-loaded into synthetic high-density lipoprotein nanodiscs, forming a potent adjuvant system (ND-MPLA/CpG) that can be readily combined with a variety of subunit antigens, including proteins and peptides...
April 24, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29701288/cytokine-expression-profile-in-the-bone-anchored-hearing-system-12-week-results-from-a-prospective-randomized-controlled-study
#15
Tim George Ate Calon, Joost van Tongeren, Omar Omar, Martin Lars Johansson, Robert-Jan Stokroos
OBJECTIVE: To study the effect of implanting the percutaneous bone-anchored hearing system (BAHS) itself and inflammation of the peri-abutment skin warrant clarification. In this study, we aimed to acquire further insight into the immune responses related to BAHS surgery and peri-implant skin inflammation. MATERIALS AND METHODS: During surgery and 12 weeks post-implantation, skin biopsies were obtained. If applicable, additional biopsies were taken during cases of inflammation...
April 27, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29698675/human-choroidal-melanocytes-express-functional-toll-like-receptors-tlrs
#16
Adrian V Cioanca, Peter J McCluskey, Steven S Eamegdool, Michele C Madigan
Toll-like receptors (TLRs) are a class of pattern recognition receptors that sense highly conserved pathogen associated antigenic determinants, triggering an innate immune response and subsequently instructing the adaptive immune system so that together, the pathogen can be eliminated. TLRs are widely distributed in human ocular tissues and cell types, and are active players in ocular inflammation. To date, the presence and function of TLRs on human choroidal melanocytes (HCMs), the most abundant choroidal cell type, have not been characterized...
April 23, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29691767/prognostic-impact-of-final-kissing-balloon-technique-after-crossover-stenting-for-the-left-main-coronary-artery-from-the-aoi-lmca-registry
#17
Koji Nishida, Mamoru Toyofuku, Takeshi Morimoto, Masanobu Ohya, Yasushi Fuku, Hirooki Higami, Kyohei Yamaji, Hiromi Muranishi, Yuhei Yamaji, Daisuke Furukawa, Tomohisa Tada, Euihong Ko, Kazushige Kadota, Kenji Ando, Hiroki Sakamoto, Takashi Tamura, Kazuya Kawai, Takeshi Kimura
It is still uncertain whether the final kissing balloon technique (FKBT) is mandatory after crossover stenting for the left main coronary artery (LMCA). Assessing Optimal Percutaneous Coronary Intervention for LMCA (AOI-LMCA) registry, a 6-center retrospective registry, enrolled 1809 consecutive patients for LMCA stenting in Japan. In the present analysis, 5-year clinical outcomes were compared between non-FKBT (n = 160) and FKBT (n = 578) groups in patients treated with crossover stenting with drug-eluting stents from the LMCA to the left anterior descending artery...
April 24, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29691386/toll-like-receptors-mediated-pathways-activate-inflammatory-responses-in-the-esophageal-mucosa-of-adult-eosinophilic-esophagitis
#18
Ángel Arias, María Vicario, David Bernardo, José M Olalla, Marina Fortea, Ana Montalban-Arques, Pilar Martínez-Fernández, Ana M González-Castro, Teresa Mota-Huertas, Laura Arias-González, Alfredo J Lucendo
OBJECTIVES: Esophageal microbiota and regulation of adaptive immunity are increasingly being investigated in eosinophilic esophagitis (EoE). Toll-like receptors (TLRs) play a central role in the initiation and maintenance of innate immune activity. Our objective was to characterize the esophageal and duodenal innate immune response in EoE and its modulation by dietary therapy. METHODS: Esophageal and duodenal biopsy samples were collected from 10 adults with untreated EoE, before and after effective treatment with a six-food elimination diet (SFED), and 10 controls with normal esophagus...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29688175/implantation-techniques-pre-dilatation-sizing-and-post-dilatation-and-the-incidence-of-scaffold-thrombosis-and-revascularization-in-lesions-treated-with-an-everolimus-eluting-bioresorbable-vascular-scaffold-insights-from-the-aida-trial
#19
Ruben Yannick G Tijssen, Robin P Kraak, Joelle Elias, Ivo M van Dongen, Deborah Nancy Kalkman, Martina Nassif, Yohei Sotomi, Taku Asano, Yuki Katagiri, Carlos Collet, Jan J Piek, Jose P S Henriques, Robbert J de Winter, Jan G Tijssen, Yoshinobu Onuma, Patrick W Serruys, Joanna J Wykrzykowska
AIMS: Absorb bioresorbable vascular scaffold (Absorb BVS) specific implantation strategies have been proposed to optimize outcomes. We analyzed whether the occurrence of definite scaffold thrombosis (ScT) and target lesion revascularization (TLR) in Absorb-treated AIDA patients was influenced by scaffold implantation techniques. METHODS AND RESULTS: Absorb BVS implantation in 1074 lesions was graded according to definitions of optimal implantation based on pre-dilatation, sizing, and post-dilatation (PSP)...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29686890/efficacy-and-safety-of-polymer-free-ultrathin-strut-sirolimus-probucol-coated-drug-eluting-stents-for-chronic-total-occlusions-insights-from-the-coroflex-isar-2000-worldwide-registry
#20
Ahmad Syadi Mahmood Zuhdi, Florian Krackhardt, Matthias W Waliszewski, Muhammad Dzafir Ismail, Michael Boxberger, Wan Azman Wan Ahmad
Objective: Coronary revascularization in chronic total occlusion (CTO) is associated with improved clinical outcomes. The choice of the coronary stent is crucial in maintaining long-term vessel patency after CTO revascularization. We investigated the efficacy and safety of polymer-free ultrathin strut sirolimus-probucol coated drug-eluting stents (PF-SES) for CTO lesions. Methods: Patients with CTO lesions treated with PF-SES were identified from the prospective multicenter international ISAR 2000 registry...
2018: Cardiology Research and Practice
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