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https://www.readbyqxmd.com/read/28208028/early-life-wildfire-smoke-exposure-is-associated-with-immune-dysregulation-and-lung-function-decrements-in-adolescence
#1
Carolyn Black, Joan E Gerriets, Justin H Fontaine, Richart W Harper, Nicholas J Kenyon, Fern Tablin, Edward S Schelegle, Lisa A Miller
RATIONALE: The long-term health effects of wildfire smoke exposure in pediatric populations are not known. OBJECTIVE: To determine if early life exposure to wildfire smoke can affect parameters of immunity and airways physiology that are detectable with maturity. METHODS: We studied a mixed gender cohort of rhesus macaque monkeys that were exposed as infants to ambient wood smoke from a series of Northern California wildfires in the summer of 2008...
February 16, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28192646/higher-expression-of-toll-like-receptors-3-7-8-and-9-in-pityriasis-rosea
#2
Mostafa Abou El-Ela, Mohamed El-Komy, Rania Abdel Hay, Rehab Hegazy, Amin Sharobim, Laila Rashed, Khalda Sayed Amr
Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Materials and Methods: Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study...
February 13, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28186978/combination-antiretroviral-therapy-cart-restores-hiv-1-infection-mediated-impairment-of-jak-stat-signaling-pathway
#3
Man-Qing Liu, Min Zhao, Wen-Hua Kong, Li Tang, Fang Wang, Ze-Rong Zhu, Xia Wang, Hong-Yan Qiu, Dun-Jin Zhou, Xu Wang, Wen-Zhe Ho, Wang Zhou
JAK-STAT signaling pathway has a crucial role in host innate immunity against viral infections, including HIV-1. We therefore examined the impact of HIV-1 infection and combination antiretroviral therapy (cART) on JAK-STAT signaling pathway. Compared to age-matched healthy donors (n = 18), HIV-1-infected subjects (n = 18) prior to cART had significantly lower expression of toll-like receptors (TLR-1/4/6/7/8/9), the IFN regulatory factors (IRF-3/7/9), and the antiviral factors (OAS-1, MxA, A3G, PKR, and Tetherin)...
February 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28184217/chlamydial-lipoproteins-stimulate-toll-like-receptors-1-2-mediated-inflammatory-responses-through-myd88-dependent-pathway
#4
Yong Wang, Qiong Liu, Ding Chen, Jie Guan, Linghui Ma, Guangming Zhong, Hengping Shu, Xiang Wu
Chlamydiae are very important pathogens which could cause several types of diseases in human, but little is known about its pathogenic mechanism. In order to elucidate host inflammatory response and the signal pathway induced by Chlamydial lipoproteins, the predicted lipoproteins of Chlamydia trachomatis were tested for their ability to induce the release of proinflammatory cytokines by mouse macrophages or human TLR (Toll-Like Receptor) expressing cell lines. The results showed that recombinant proteins of C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28182798/expression-of-genes-belonging-to-the-interacting-tlr-cascades-nadph-oxidase-and-mitochondrial-oxidative-phosphorylation-in-septic-patients
#5
Laura A Nucci, Sidnéia S Santos, Milena K C Brunialti, Narendra Kumar Sharma, Flavia R Machado, Murillo Assunção, Luciano C P de Azevedo, Reinaldo Salomao
BACKGROUND AND OBJECTIVES: Sepsis is a complex disease that is characterized by activation and inhibition of different cell signaling pathways according to the disease stage. Here, we evaluated genes involved in the TLR signaling pathway, oxidative phosphorylation and oxidative metabolism, aiming to assess their interactions and resulting cell functions and pathways that are disturbed in septic patients. MATERIALS AND METHODS: Blood samples were obtained from 16 patients with sepsis secondary to community acquired pneumonia at admission (D0), and after 7 days (D7, N = 10) of therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28174321/time-course-effect-of-lps-on-tlrs-expression-and-steroidogenesis-in-the-goose-ovary
#6
ShiJia Ying, JiaJia Guo, ZiChun Dai, HuanXi Zhu, JianNing Yu, WeiMing Ma, JiaYI Li, Muhammad Faheem Akhtar, ZhenDan Shi
The ovary of Chinese goose is easily infected by microorganisms because of mating behaviour on water, which causes decreased laying performance. This study investigated the time course effect of lipopolysaccharide (LPS) on the steroidogenesis and mRNA expression of Toll-like receptors (TLRs), a class of key pattern recognition receptor, in the breeding goose ovary. The laying geese were treated intravenously with LPS for 0, 6, 12, 24 and 36 h, and all birds were slaughtered approximately 8 h after oviposition...
February 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28168366/evolution-of-patency-rates-of-self-expandable-bare-metal-stents-for-endovascular-treatment-of-femoro-popliteal-arterial-occlusive-disease-does-stent-design-matter
#7
Karla Maria Treitl, Benedikt Woerner, Regina Schinner, Michael Czihal, Susan Notohamiprodjo, Ulrich Hoffmann, Marcus Treitl
OBJECTIVE: To analyse the patency rates of femoro-popliteal stenting with different self-expandable Nitinol stent-designs. METHODS: Two hundred and twenty-two patients (142 (64%) male; age 72.4 ± 11.6 years) with symptomatic femoro-popliteal peripheral arterial occlusive disease (PAOD) underwent percutaneous transluminal angioplasty (PTA) and stenting with three different Nitinol stents (interwoven IW: n = 70; closed-cell CC: n = 85; open-cell OC: n = 67)...
February 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28166799/toll-like-receptor-3-activation-selectively-reverses-hiv-latency-in-microglial-cells
#8
David Alvarez-Carbonell, Yoelvis Garcia-Mesa, Stephanie Milne, Biswajit Das, Curtis Dobrowolski, Roxana Rojas, Jonathan Karn
BACKGROUND: Multiple toll-like receptors (TLRs) are expressed in cells of the monocytic lineage, including microglia, which constitute the major reservoir for human immunodeficiency virus (HIV) infection in the brain. We hypothesized that TLR receptor mediated responses to inflammatory conditions by microglial cells in the central nervous system (CNS) are able to induce latent HIV proviruses, and contribute to the etiology of HIV-associated neurocognitive disorders. RESULTS: Newly developed human microglial cell lines (hµglia), obtained by immortalizing human primary microglia with simian virus-40 (SV40) large T antigen and the human telomerase reverse transcriptase, were used to generate latently infected cells using a single-round HIV virus carrying a green fluorescence protein reporter (hµglia/HIV, clones HC01 and HC69)...
February 6, 2017: Retrovirology
https://www.readbyqxmd.com/read/28163279/impact-of-vessel-diameter-measured-by-preprocedural-computed-tomography-angiography-on-immediate-and-late-outcomes-of-endovascular-therapy-for-iliac-artery-diseases
#9
Sung-Jin Hong, Young-Guk Ko, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
BACKGROUND: We evaluated whether vessel diameters measured by preprocedural computed tomography angiography (CTA) affects the immediate and late outcomes of endovascular therapy for iliac artery diseases.Methods and Results:A total of 254 patients who underwent endovascular treatment for iliac artery diseases were retrospectively evaluated. Minimum vessel diameters were measured on preprocedural CTA images at target lesions, common iliac arteries, and external iliac arteries (EIA)...
February 3, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28159691/studies-on-expression-pattern-of-toll-like-receptor-5-tlr5-in-edwardsiella-tarda-infected-pangasianodon-hypophthalmus
#10
Poojashree Kachigere Jayaramu, Gayatri Tripathi, A Pavan Kumar, Jeena Keezhedath, Mujahid Khan Pathan, Pani Prasad Kurcheti
TLR5 is one of the important PRR (pathogen recognition receptors) and plays a fundamental role in pathogen recognition and activation of innate immune responses. It recognizes bacterial flagellin and stimulates the production of proinflammatory cytokines, through signalling via the adaptor protein MyD88. In this study, we characterized partial TLR5 (soluble form) gene from Pangasianodon hypophthalmus and analysed its expression profile upon challenge by Edwardsiella tarda. Bioinformatic analysis of gene sequence revealed a putative protein of 266 amino acids with four Leucine rich repeats...
January 31, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28150119/second-generation-versus-first-generation-drug-eluting-stents-in-patients-with-and-without-diabetes-mellitus-pooled-analysis-from-the-reset-and-next-trials
#11
Kenji Nakatsuma, Hiroki Shiomi, Masahiro Natsuaki, Takeshi Morimoto, Keiichi Igarashi, Kazushige Kadota, Toshiya Muramatsu, Kengo Tanabe, Yoshihiro Morino, Takashi Akasaka, Yoshihisa Nakagawa, Ken Kozuma, Takeshi Kimura
The impact of second-generation drug-eluting stent (G2-DES) implantations compared with first-generation drug-eluting stents (G1-DES) implantations on long-term clinical outcomes after percutaneous coronary intervention in patients with and without diabetes mellitus (DM) has not yet been adequately assessed. This pooled analysis compared 3-year clinical outcomes between G1- and G2-DES according to the presence or absence of DM, using individual patient-level data from the RESET and NEXT trials. Among 6431 patients, G1-DES and G2-DES were used in 713 and 2211 patients, respectively, in the DM stratum, and 887 and 2620 patients, respectively, in the non-DM stratum...
February 1, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28139053/anti-inflammatory-effects-of-the-petasin-phyto-drug-ze339-are-mediated-by-inhibition-of-the-stat-pathway
#12
Sabrina A Steiert, Ulrich M Zissler, Adam M Chaker, Julia Esser-von-Bieren, Daniela Dittlein, Ferdinand Guerth, Constanze A Jakwerth, Guido Piontek, Catherine Zahner, Juergen Drewe, Claudia Traidl-Hoffmann, Carsten B Schmidt-Weber, Stefanie Gilles
Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB4 in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll-like-receptor (TLR)-ligands or cytokines, in presence or absence of Ze339...
January 31, 2017: BioFactors
https://www.readbyqxmd.com/read/28134982/%C3%AE-synuclein-induces-microglial-cell-migration-through-stimulating-hif-1%C3%AE-accumulation
#13
Hongfei Qiao, Xijing He, Qiaojun Zhang, Ni Zhang, Libo Li, Yanping Hui, Wenjuan Li, Dong Wang, Zhonghen Wu
Microglial cell migration and infiltration plays a critical role in spinal cord injury after thoracoabdominal aortic surgery. In our previous study, α-synuclein, a presynaptic protein was shown to be released from injured neurons and cause microglial cell activation. Here, we aimed to explore the effect of α-synuclein on microglial cell migration. Primary microglial cells were isolated from Sprague-Dawley rats and then exposed different doses (0.2, 0.4, and 0.6 μM) of α-synuclein oligomers. The mRNA and protein levels of HIF-1α were then analyzed by qRT-PCR and Western blot...
January 30, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28128079/is-there-a-link-between-human-herpesvirus-infection-and-toll-like-receptors-in-the-pathogenesis-of-pityriasis-rosea-a-case-control-study
#14
Mostafa Abou El-Ela, Eman Shaarawy, Mohamed El-Komy, Marwa Fawzy, Rania Abdel Hay, Rehab Hegazy, Amin Sharobim, Nadine Moustafa, Laila Rashed, Khalda Sayed Sayed Amr
Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Biopsy was obtained from the PR lesion and from the healthy skin of controls for detection of HHV-6 and 7 as well as TLRs 2, 3, 4, 7, 8, and 9 gene expression using real-time polymerase chain reaction (PCR)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28126350/peptostreptococcus-anaerobius-induces-intracellular-cholesterol-biosynthesis-in-colon-cells-to-induce-proliferation-and-causes-dysplasia-in-mice
#15
Ho Tsoi, Eagle Sh Chu, Xiang Zhang, Jianqiu Sheng, Daniel Nakatsu, Siew C Ng, Anthony Wh Chan, Francis Kl Chan, Joseph Jy Sung, Jun Yu
BACKGROUND & AIMS: Stool samples from patients with colorectal cancer (CRC) have a higher abundance of Peptostreptococcus anaerobius than stool from individuals without CRC, based on metagenome sequencing. We investigated whether P anaerobius contributes to colon tumor formation in mice and its possible mechanisms of carcinogenesis. METHODS: We performed quantitative PCR analyses to measure P anaerobius in 112 stool samples and 255 colon biopsies from patients with CRC or advanced adenoma and from healthy individuals (controls) undergoing colonoscopy examination at hospitals in Hong Kong and Beijing...
January 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28125549/o-001-a-diagnostic-approach-of-immune-dysregulation-on-very-early-onset-ibd
#16
Judith Kelsen, Noor Dawany, Maire Conrad, Kathleen Sullivan, Edward Behrens, Marcella Devoto
BACKGROUND: Immune deficiencies have been associated with inflammatory bowel disease (IBD), and are reported to be particularly enriched in patients with very early-onset IBD (VEO-IBD). However, the actual frequency of primary immune deficiencies in an unselected cohort of patients with VEO-IBD is not known, nor is the optimal screening approach for this population. This study was undertaken to identify a diagnostic approach that will enhance identification of children with primary immune deficiencies who present with VEO-IBD...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28124644/differences-in-innate-immune-response-gene-regulation-in-the-middle-ear-of-children-who-are-otitis-prone-and-in-those-not-otitis-prone
#17
Ravinder Kaur, Janet Casey, Michael Pichichero
OBJECTIVE: Acute otitis media (AOM) causes an inflammatory response in the middle ear. We assessed differences in innate immune responses involved in bacterial defense at onset of AOM in children who were stringently defined as otitis prone (sOP) and children not otitis prone (NOP). STUDY DESIGN: Innate immune genes analysis from middle ear fluid (MEF) samples of children. METHODS: Genes of toll-like receptors (TLR), nod-like and retinoic acid-inducible gene-I-like receptors, downstream effectors important for inflammation and apoptosis, including cytokines and chemokines, were studied from MEF samples by using a real-time polymerase chain reaction array...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28114971/molecular-alterations-in-skeletal-muscle-in-rheumatoid-arthritis-are-related-to-disease-activity-physical-inactivity-and-disability
#18
Kim M Huffman, Ryan Jessee, Brian Andonian, Brittany N Davis, Rachel Narowski, Janet L Huebner, Virginia B Kraus, Julie McCracken, Brian F Gilmore, K Noelle Tune, Milton Campbell, Timothy R Koves, Deborah M Muoio, Monica J Hubal, William E Kraus
BACKGROUND: To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. METHODS: Persons with seropositive or erosive RA (n = 51) and control subjects matched for age, gender, race, body mass index (BMI), and physical activity (n = 51) underwent assessment of disease activity, disability, pain, physical activity and thigh muscle biopsies. Muscle tissue was used for measurement of pro-inflammatory markers, transcriptomics, and comprehensive profiling of metabolic intermediates...
January 23, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28114604/topical-imiquimod-plus-nab-paclitaxel-for-breast-cancer-cutaneous-metastases-a-phase-2-clinical-trial
#19
Lupe G Salazar, Hailing Lu, Jessica L Reichow, Jennifer S Childs, Andrew L Coveler, Doreen M Higgins, James Waisman, Kimberly H Allison, Yushe Dang, Mary L Disis
Importance: Salvage chemotherapy for recurrent chest wall lesions in breast cancer results in response rates of 20% to 30%. Preclinical studies showed significant disease regression could be induced in murine chest wall mammary cancers with a topical toll-like receptor (TLR)-7 agonist, imiquimod. Objective: To evaluate the safety and objective response rate (ORR) of imiquimod in combination with systemic albumin bound paclitaxel in treatment-refractory breast cancer of the chest wall...
January 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28106157/tlr4-antagonist-fp7-inhibits-lps-induced-cytokine-production-and-glycolytic-reprogramming-in-dendritic-cells-and-protects-mice-from-lethal-influenza-infection
#20
Laure Perrin-Cocon, Anne Aublin-Gex, Stefania E Sestito, Kari Ann Shirey, Mira C Patel, Patrice André, Jorge C Blanco, Stefanie N Vogel, Francesco Peri, Vincent Lotteau
Dysregulated Toll-like receptor (TLR)-4 activation is involved in acute systemic sepsis, chronic inflammatory diseases, such as atherosclerosis and diabetes, and in viral infections, such as influenza infection. Thus, therapeutic control of the TLR4 signalling pathway is of major interest. Here we tested the activity of the small-molecule synthetic TLR4 antagonist, FP7, in vitro on human monocytes and monocyte-derived dendritic cells (DCs) and in vivo during influenza virus infection of mice. Our results indicate that FP7 antagonized the secretion of proinflammatory cytokines (IL-6, IL-8, and MIP-1β) by monocytes and DCs (IC50 < 1 μM) and prevented DC maturation upon TLR4 activation by ultrapure lipopolysaccharide (LPS)...
January 20, 2017: Scientific Reports
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