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https://www.readbyqxmd.com/read/28729250/stellarex-drug-coated-balloon-for-treatment-of-femoropopliteal-disease-12-month-outcomes-from-the-randomized-illumenate-pivotal-and-pharmacokinetic-studies
#1
Prakash Krishnan, Peter Faries, Khusrow Niazi, Ash Jain, Ravish Sachar, William B Bachinsky, Joseph A Cardenas, Martin Werner, Marianne Brodmann, J A Mustapha, Carlos I Mena-Hurtado, Michael R Jaff, Andrew H Holden, Sean P Lyden
Background -Drug-coated balloons (DCB) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Due to differences in excipients, paclitaxel dose and coating morphologies, varying clinical outcomes have been observed with different DCBs. We report the results of two studies investigating the pharmacokinetic (PK) and clinical outcomes of a new DCB to treat femoropopliteal disease. Methods -In the ILLUMENATE Pivotal Study, 300 symptomatic patients (Rutherford class 2-4), were randomized to DCB (N=200) or standard angioplasty (PTA) (N=100)...
July 20, 2017: Circulation
https://www.readbyqxmd.com/read/28725012/phycocyanin-attenuates-pulmonary-fibrosis-via-the-tlr2-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#2
Chengcheng Li, Yan Yu, Wenjun Li, Bo Liu, Xudong Jiao, Xinyu Song, Changjun Lv, Song Qin
Our aim was to investigate the effects of phycocyanin (PC) on bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, C57 BL/6 wild-type (WT) mice and toll-like receptor (TLR) 2 deficient mice were treated with PC for 28 days following BLM exposure. Serum and lung tissues were collected on days 3, 7 and 28. Data shows PC significantly decreased the levels of hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast specific protein-1 (S100A4) and α-smooth muscle actin (α-SMA) but dramatically increased E-cadherin and podoplanin (PDPN) expression on day 28...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715767/non-human-primates-as-a-model-for-understanding-the-mechanism-of-action-of-toll-like-receptor-based-vaccine-adjuvants
#3
REVIEW
Elizabeth A Thompson, Karin Loré
While transgenic mouse models are powerful for understanding how the immune system is manipulated by vaccines, they cannot fully recapitulate the characteristics of the innate immune responses leading to adaptive immunity after vaccination in humans. Outbred non-human primates are far more representative models of human vaccine responses as there is high degree of similarities in immune cell subset distributions, receptor expression (including toll-like receptors; TLRs), and immune cell functions, in addition to modeling doses and injection sites more accurately...
July 14, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28714525/dedicated-bifurcation-stents-or-regular-drug-eluting-stents-in-distal-left-main-stenosis-a-retrospective-study
#4
Adam Kern, Robert J Gil, Krystian Bojko, Bartłomiej Rzeszowski, Krzysztof Bednarski, Jerzy Górny, Jacek Bil
BACKGROUND: Mainly atherosclerosis develops in distal left main (LM) within bifurcation or trifurcation. The aim of this study was to analyze the strategy of distal LM stenosis treatment and associated clinical outcomes in a large hospital in Northern Poland. METHODS: The study population consisted of consecutive patients with stable coronary artery disease or acute coronary syndrome (ACS) and distal LM stenosis who were hospitalized between June 2012 and June 2013...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28711715/novel-peptide-motifs-from-lysozyme-suppress-pro-inflammatory-cytokines-in-macrophages-by-antagonizing-toll-like-receptor-and-lps-scavenging-action
#5
Hisham R Ibrahim, Kosuke Hamasaki, Takeshi Miyata
Lysozyme is commonly found in spots where bacterial infections are most likely to enter the body. Earlier we found that lysozyme possesses five antimicrobial peptide motifs in its N-terminal region which can be generated by newborn pepsin. In this study, we explore the role of these peptides in the anti-inflammatory activity of lysozyme. The five peptides, helix1 (H1), helix2 (H2), H1 and H2 connected with a loop (HLH), H2 extended with either 2 β-strands (H2-S12) or 3 β-strands (H2-S13), were synthesized and examined for anti-inflammatory action...
July 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28711708/ezetimibe-and-simvastatin-combination-inhibits-and-reverses-the-pro-inflammatory-and-pro-atherogenic-effects-of-cream-in-obese-patients
#6
Husam Ghanim, Kelly Green, Sanaa Abuaysheh, Reema Patel, Manav Batra, Ajay Chaudhuri, Antoine Makdissi, Nitesh D Kuhadiya, Paresh Dandona
BACKGROUND AND AIMS: Inflammation and postprandial lipemia are associated with increased cardiovascular disease. We investigated whether ezetimibe and simvastatin combination, a lipid lowering combination of simvastatin and ezetimibe, exerts an anti-inflammatory effect in the fasting state and after dairy cream intake. METHODS: Twenty obese patients were randomized to either ezetimibe and simvastatin combination or placebo treatment for 6 weeks. All patients were asked to ingest 33 ml of dairy cream (300 Calories) at the beginning and at the end of intervention...
June 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28701256/toll-like-receptor-expression-patterns-in-the-rat-uterus-during-post-partum-involution
#7
Emel Alan, Narin Liman
Toll-like receptors (TLRs) belong to a family of pathogen recognition receptors and play critical roles in detecting and responding to invading pathogens. TLR expression could be significant because, in the uterus, the reproductive tract is an important site of exposure to and infection by pathogens during the post partum involution period. To clarify the expression and localisation patterns of TLRs in the rat uterus on Days 1, 3, 5 and 10 post partum (PP1, PP3, PP5 and PP10 respectively), immunohistochemistry and western blotting were used to analyse TLR1-7, TLR9 and TLR10...
July 13, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28698128/genome-wide-identification-characterization-and-expression-analyses-of-tlrs-in-yesso-scallop-patinopecten-yessoensis-provide-insight-into-the-disparity-of-responses-to-acidifying-exposure-in-bivalves
#8
Qiang Xing, Huan Liao, Xiaogang Xun, Jing Wang, Zhengrui Zhang, Zujing Yang, Xiaoting Huang, Zhenmin Bao
Toll-like receptors (TLRs) play a crucial role in innate immunity by recognizing specific pathogen-associated molecular patterns, including lipoproteins, lipopeptides, lipopolysaccharide, flagellin, dsRNA, ssRNA and CpG DNA motifs. Although significant effects of TLRs on immunity have been reported in most vertebrates and some invertebrates, the complete TLR superfamily has not been systematically characterized in scallops. In this study, 18 TLR genes were identified from Yesso scallop (Patinopecten yessoensis) using whole-genome scanning...
July 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28698123/identification-molecular-evolution-of-toll-like-receptors-in-a-tibetan-schizothoracine-fish-gymnocypris-eckloni-and-their-expression-profiles-in-response-to-acute-hypoxia
#9
Delin Qi, Mingzhe Xia, Yan Chao, Yongli Zhao, Rongrong Wu
Hypoxia plays an important role in regulating a variety of physiological responses as well as in pathological situations, but to date the roles of Toll-like receptors (TLRs) in fish in response to hypoxia are still poorly understood. Here, we sequenced the transcriptome of G. eckloni and identified the members of TLR family by scanning transcriptome, and then investigated the expression profiles of a complete set of TLRs in G. eckloni in response to acute hypoxia (4 h at DO = 0.3 ± 0.1 mg/L). The de novo-assembled transcriptome consisted of a total of 162,235 transcripts, further clustered into 110,231 unigenes...
July 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28694808/mycobacterium-tuberculosis-dosr-regulon-gene-rv2004c-encodes-a-novel-antigen-with-pro-inflammatory-functions-and-potential-diagnostic-application-for-detection-of-latent-tuberculosis
#10
Sankara Narayana Doddam, Vidyullatha Peddireddy, Niyaz Ahmed
Approximately 1.7 billion people in the world harbor latent Mycobacterium tuberculosis (Mtb) with a substantial risk of progression to clinical outcome. Containment of these seed beds of Mtb is essential to eliminate tuberculosis completely in high burden settings such as India. Hence, there is an urgent need for the identification of new serological markers for detection or vaccine candidates to prevent latent tuberculosis infection (LTBI). DosR regulon antigens of Mtb might serve as attractive targets for LTBI diagnosis or vaccine development as they are specifically expressed and are upregulated during latent phase...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28692144/toll-like-receptor-1-and-10-gene-polymorphisms-are-linked-to-post-bronchiolitis-asthma-in-adolescence
#11
Sari Törmänen, Matti Korppi, Eero Lauhkonen, Petri Koponen, Johanna Teräsjärvi, Juho Vuononvirta, Merja Helminen, Qiushui He, Kirsi Nuolivirta
AIM: Toll-like receptors (TLR) are innate immunity molecules and our previous studies found that TLR1 gene polymorphism was associated with post-bronchiolitis asthma at 1-6 years of age, as was TLR10 at 5-7 years of age. This study examined any associations at 11-13 years of age. METHODS: This prospective follow-up study was part of an on-going evaluation of children admitted to Tampere University Hospital Finland for bronchiolitis in 2001-2004 at less than six months of age...
July 10, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28680194/syk-plays-a-critical-role-in-the-expression-and-activation-of-irak1-in-lps-treated-macrophages
#12
Jae Gwang Park, Young-Jin Son, Byong Chul Yoo, Woo Seok Yang, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho
To address how interleukin-1 receptor-associated kinase 1 (IRAK1) is controlled by other enzymes activated by toll-like receptor (TLR) 4, we investigated the possibility that spleen tyrosine kinase (Syk), a protein tyrosine kinase that is activated at an earlier stage during TLR4 activation, plays a central role in regulating the functional activation of IRAK1. Indeed, we found that overexpression of myeloid differentiation primary response gene 88 (MyD88), an adaptor molecule that drives TLR signaling, induced IRAK1 expression and that piceatannol, a Syk inhibitor, successfully suppressed the MyD88-dependent upregulation of IRAK1 under LPS treatment conditions...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28671552/mid-term-clinical-outcomes-with-everolimus-eluting-bioresorbable-scaffolds-versus-everolimus-eluting-metallic-stents-for-percutaneous-coronary-interventions-a-meta-analysis-of-randomized-trials
#13
Salvatore Cassese, Byrne A Robert, Peter Jüni, Joanna J Wykrzykowska, Serban Puricel, Gjin Ndrepepa, Heribert Schunkert, Massimiliano Fusaro, Stephane Cook, Takeshi Kimura, Jose P S Henriques, Patrick W Serruys, Stephan Windecker, Adnan Kastrati
AIMS: To compare the mid-term clinical outcomes of patients treated with everolimus-eluting bioresorbable scaffold (BVS) versus everolimus-eluting metallic stent (EES) for percutaneous coronary intervention. METHODS AND RESULTS: We performed a meta-analysis of aggregate data by searching Medline, EMBASE, Cochrane databases and proceedings of international meetings for randomized trials reporting the clinical outcomes beyond 1 year of patients treated with BVS versus EES...
July 4, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28665921/rhododendrin-inhibits-toll-like-receptor-7-mediated-psoriasis-like-skin-inflammation-in-mice
#14
Yoon-Jae Jeon, Shyam Kishor Sah, Hee Seung Yang, Ji Hae Lee, Jongheon Shin, Tae-Yoon Kim
Many active compounds present in Rhododendron brachycarpum have been used in traditional Oriental medicine for the treatment of various skin diseases. However, the precise mechanism of action of the compounds isolated from R. brachycarpum and their relevance as therapeutics for the treatment of psoriasis remain elusive. In this study, we report that rhododendrin isolated from R. brachycarpum strongly inhibits imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice. We showed that topical treatment with rhododendrin reduces IMQ-induced skin hyperplasia, inflammatory mononuclear cell infiltration and the expression of pro-inflammatory mediators in mouse skin...
June 30, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28662496/macrophage-inflammatory-protein-2-in-high-mobility-group-box-1-secretion-of-macrophage-cells-exposed-to-lipopolysaccharide
#15
Qin Chaochao, Guohua Lou, Ying Yang, Yanning Liu, Ying Hu, Zheng Min, Ping Chen, Jiliang He, Zhi Chen
BACKGROUND/AIMS: Macrophage inflammatory protein-2 (MIP-2), a type of leukocyte chemokine, is primarily produced by macrophages, and levels increase significantly in early inflammation. However, the precise biological functions and mechanisms of MIP-2 in the development of inflammation remain unclear. The purposes of the present study were to investigate the role of MIP-2 in inflammation induced by lipopolysaccharide (LPS) in vitro and to determine the possibility of blocking the high mobility group box 1 (HMGB1) signalling pathway via MIP-2 inhibition...
June 26, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28662409/human-placental-mesenchymal-stem-cells-of-fetal-origins-alleviated-inflammation-and-fibrosis-by-attenuating-myd88-signaling-in-bleomycin-induced-pulmonary-fibrosis-mice
#16
Feng Li, Fei Han, Hui Li, Jia Zhang, Xia Qiao, Juan Shi, Li Yang, Jianda Dong, Meihui Luo, Jun Wei, Xiaoming Liu
Pulmonary fibrosis is a progressive lung disease that its pathogenic mechanism currently is incompletely understood. Toll-like receptor (TLR) signaling has recently been identified as a regulator of inflammation and pulmonary fibrosis. In addition, mesenchymal stem cells (MSCs) of different origins offer a great promise in treatment of idiopathic pulmonary fibrosis (IPF). However mechanisms of pathogenic roles of TLR signaling and therapeutic effects of MSCs in the IPF remain elusive. In present study, the involvement of TLR signaling and the therapeutic role of MSCs were interrogated in MyD88-deficient mice using human placental MSCs of fetal origins (hfPMSCs)...
June 26, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28641471/evaluation-of-immunomodulatory-effects-of-zearalenone-in-mice
#17
Mohammad Rafiqul Islam, Jong Won Kim, Yoon-Seok Roh, Jong-Hoon Kim, Han Kang Min, Hyung-Joo Kwon, Chae Woong Lim, Bumseok Kim
Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by Fusarium species. The toxicity of ZEA has been evaluated for reproductive and developmental effects; however, there is little evidence about its acute toxicity or general immunotoxicity. In the present study, immune regulatory functions were investigated in mice that had been exposed to ZEA (5 or 20 mg/kg BW) daily for 14 days. Results showed that sub-populations of CD4(+), CD8(+) and CD11c(+) cells in the spleen and CD4(+), CD8(+) and F4/80(+) cells in the mesenteric lymph nodes (MLN) of ZEA (20 mg/kg)-exposed hosts were decreased compared to those in the control mice...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28637878/cd4-t-cell-and-nk-cell-interplay-key-to-regression-of-mhc-class-i-low-tumors-upon-tlr7-8-agonist-therapy
#18
Elien M Doorduijn, Marjolein Sluijter, Daniela C Salvatori, Serenella Silvestri, Saskia Maas, Ramon Arens, Ferry Ossendorp, Sjoerd H van der Burg, Thorbald van Hall
One of the next challenges in cancer immunotherapy is the resistance of tumors to T cell-based treatments through loss of MHC class I. Here, we show that under these circumstances, the Toll-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 ligand poly I:C or TLR9 ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4(+) T cells, whereas activated CD8(+) T cells were dispensable. Application of the innate immune stimulator at a distant site activated NK cells and thereby elicited tumor-specific T-cell responses in tumor-bearing mice...
June 21, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28635072/plgf-enhances-tlr-dependent-inflammatory-responses-in-human-mononuclear-phagocytes
#19
Laura F Newell, Shernan G Holtan, Jane E Yates, Leonardo Pereira, Jeffrey W Tyner, Irina Burd, Grover C Bagby
PROBLEM: Levels of placental growth factor (PlGF) peak during third trimester of pregnancy, a time when women are at increased risk of virus-induced morbidity. We hypothesized PlGF might contribute to an exaggerated inflammatory response to Toll-like receptor (TLR) activation. METHOD OF STUDY: Primary human adult and cord blood CD14(+) cells were cultured in the presence of TLR ligands and/or PlGF. RESULTS: PlGF significantly enhanced the magnitude and duration of TNF messenger RNA and protein production by TLR-7/8-activated monocytes, and increased subsequent production of TNF-independent inflammatory cytokines...
June 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28629622/optical-coherence-tomography-compared-with-fractional-flow-reserve-guided-approach-in-acute-coronary-syndromes-a-propensity-matched-analysis
#20
Fabrizio D'Ascenzo, Mario Iannaccone, Ovidio De Filippo, Antonio Maria Leone, Giampaolo Niccoli, Filippo Zilio, Fabrizio Ugo, Enrico Cerrato, Massimo Fineschi, Massimo Mancone, Stefano Rigattieri, Nicolas Amabile, Marco Ferlini, Gennaro Sardella, Alberto Cresti, Umberto Barbero, Pascal Motreff, Francesco Colombo, Salvatore Colangelo, Roberto Garbo, Giuseppe Biondi-Zoccai, Corrado Tamburino, Antonio Montefusco, Pierlugi Omedè, Claudio Moretti, Maurizio D'amico, Geraud Souteyrand, Fiorenzo Gaita, Ugo Limbruno, Andrea Picchi
AIM: To compare in patients with ACS (acute coronary syndromes) a PCI (percutaneous coronary intervention) approach based on FFR (fractional flow reserve) vs. one based on OCT (optical coherence tomography). METHODS AND RESULTS: Consecutive patients admitted for ACS and treated with a PCI approach based on OCT or on FFR (recruited in two different studies) were compared and matched with propensity score analysis. Target Lesion revascularization (TLR) was the primary end point, while major adverse cardiovascular events [MACEs defined as the composite of death from cardiac causes, non-fatal MI, clinically driven target vessel revascularization (TVR), or re-hospitalization due to unstable angina] were the secondary ones...
June 3, 2017: International Journal of Cardiology
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