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https://www.readbyqxmd.com/read/28912808/association-of-polymorphisms-in-toll-like-receptors-4-and-9-with-autoimmune-thyroid-disease-in-korean-pediatric-patients
#1
Won Kyoung Cho, Jung-Pil Jang, Eun-Jeong Choi, Moonbae Ahn, Shin Hee Kim, Kyoung Soon Cho, So Hyun Park, In Cheol Baek, Min Ho Jung, Tai-Gyu Kim, Byung-Kyu Suh
BACKGROUND: Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. METHODS: Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. RESULTS: GD showed higher frequencies of the TLR4 rs1927911 C allele than control...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28910320/differential-gene-expression-following-tlr-stimulation-in-rag1-mutant-zebrafish-tissues-and-morphological-descriptions-of-lymphocyte-like-cell-populations
#2
Preeti J Muire, Larry A Hanson, Robert Wills, Lora Petrie-Hanson
In the absence of lymphocytes, rag1-/- mutant zebrafish develop protective immunity to bacteria. In mammals, induction of protection by innate immunity can be mediated by macrophages or natural killer (NK) cells. To elucidate potential responsive cell populations, we morphologically characterized lymphocyte-like cells (LLCs) from liver, spleen and kidney hematopoietic tissues. In fish, these cells include NK cells and Non-specific cytotoxic cells (NCCs). We also evaluated the transcriptional expression response of select genes that are important indicators of NK and macrophage activation after exposure to specific TLR ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28901470/tlr5-7-mediated-pi3k-activation-triggers-epithelial-mesenchymal-transition-of-ovarian-cancer-cells-through-wave3-dependent-mesothelin-or-oct4-sox2-expression
#3
Ga Bin Park, Daejin Kim
Toll-like receptor (TLR)-mediated signaling induces cell migration or invasion in several tumors and various stages of cancer. Interactions of mesothelin, a 40-kDa cell surface glycoprotein, with cancer antigen 125 (CA125) is associated with drug resistance, metastasis, and poor clinical outcome of ovarian cancer patients. In this study, we examined the role of TLR5 and TLR7 in the metastasis of ovarian cancer through the induction of mesothelin/CA125 expression and investigated its underlying mechanism. TLR5 agonist (flagellin) and TLR7 agonist (imiquimod) upregulated mesenchymal phenotypes and produced epithelial-mesenchymal transition (EMT)-related cytokines in the SKOV3 cells; however, TLR7 expressing CaOV3 cells had no response to the specific ligand, imiquimod, for enhancing its EMT processes...
September 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28900156/dual-roles-of-two-isoforms-of-autophagy-related-gene-atg10-in-hcv-subgenomic-replicon-mediated-autophagy-flux-and-innate-immunity
#4
Qiong Zhao, Zhan-Ying Hu, Jing-Pu Zhang, Jian-Dong Jiang, Yuan-Yuan Ma, Jian-Rui Li, Zong-Gen Peng, Jin-Hua Chen
Autophagy and immune response are two defense systems that human-body uses against viral infection. Previous studies documented that some viral mechanisms circumvented host immunity mechanisms and hijacked autophagy for its replication and survival. Here, we focus on interactions between autophagy mechanism and innate-immune-response in HCV-subgenomic replicon cells to find a mechanism linking the two pathways. We report distinct effects of two autophagy-related protein ATG10s on HCV-subgenomic replication...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899359/transcript-profiling-of-the-immunological-interactions-between-actinobacillus-pleuropneumoniae-serotype-7-and-the-host-by-dual-rna-seq
#5
Ping Li, Zhiwen Xu, Xiangang Sun, Yue Yin, Yi Fan, Jun Zhao, Xiyu Mao, Jianbo Huang, Fan Yang, Ling Zhu
BACKGROUND: The complexity of the pathogenic mechanism underlying the host immune response to Actinobacillus pleuropneumonia (App) makes the use of preventive measures difficult, and a more global view of the host-pathogen interactions and new insights into this process are urgently needed to reveal the pathogenic and immune mechanisms underlying App infection. Here, we infected specific pathogen-free Mus musculus with App serotype 7 by intranasal inoculation to construct an acute hemorrhagic pneumonia infection model and isolated the infected lungs for analysis of the interactions by dual RNA-seq...
September 12, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28891416/role-of-innate-immunity-in-preeclampsia-a-systematic-review
#6
Ana P Bouças, Bianca M de Souza, Andrea C Bauer, Daisy Crispim
Innate immune system dysfunction has been known to be a key player in preeclampsia (PE). Activation of the maternal innate immunity may be triggered by invading microorganisms or endogenous ligands, which are detected by different pattern recognition receptors (PRRs). Although some studies have linked PRR activation to PE, it is still unclear if dysregulated PRR expression is associated with the development of this complication. Therefore, we conducted a systematic review of the literature, searching articles that evaluated associations of PRRs with PE...
October 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28890293/epidermal-barrier-reaction-to-an-in-vitro-psoriatic-microenvironment
#7
Elena Donetti, Laura Cornaghi, Francesca Arnaboldi, Federica Ricceri, Leonardo Pescitelli, Martina Maiocchi, Francesco Carriero, Franz Baruffaldi Preis, Francesca Prignano
Keratinocytes (KCs) and Langerhans cells (LCs) contribute to create the epidermal barrier. To form a functional epidermis, KCs express filaggrin and Toll-like Receptors (TLRs). LCs are the first line of epidermal defence and can be activated by interleukin (IL)-17 and Tumor Necrosis Factor (TNF)-alpha. In psoriasis, an alteration of TLR expression, a defective expression of filaggrin, and LC activation occur. In organotypic cultures of human skin we investigated the interplay between IL-17 and TNF-alpha on i) expression of filaggrin, TLR2, 7 and 9, and Nuclear Factor (NF)-kB localization by immunofluorescence and ii) LC ultrastructural features by transmission electron microscopy...
September 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28888110/association-of-toll-like-receptor-polymorphisms-with-susceptibility-to-chikungunya-virus-infection
#8
Sudip Kumar Dutta, Anusri Tripathi
Chikungunya virus (CHIKV) infection leads to activation of innate immune response by triggering Toll-like receptor (TLR) pathways resulting in elevated cytokines and type-I interferon levels. Genetic variations of these genes may influence human CHIKV-susceptibility and disease progression. Present study aimed to identify role of TLR polymorphisms in CHIKV-susceptibility and their association with cytokines and clinical symptoms. This is the first study illustrating certain genotypes of TLR-7 and TLR-8 SNPs viz...
September 6, 2017: Virology
https://www.readbyqxmd.com/read/28886690/transcriptome-profiling-of-antiviral-immune-and-dietary-fatty-acid-dependent-responses-of-atlantic-salmon-macrophage-like-cells
#9
Khalil Eslamloo, Xi Xue, Jennifer R Hall, Nicole C Smith, Albert Caballero-Solares, Christopher C Parrish, Richard G Taylor, Matthew L Rise
BACKGROUND: Due to the limited availability and high cost of fish oil in the face of increasing aquaculture production, there is a need to reduce usage of fish oil in aquafeeds without compromising farm fish health. Therefore, the present study was conducted to determine if different levels of vegetable and fish oils can alter antiviral responses of salmon macrophage-like cells (MLCs). Atlantic salmon (Salmo salar) were fed diets containing 7.4% (FO7) or 5.1% (FO5) fish oil. These diets were designed to be relatively low in EPA + DHA (i...
September 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28884985/staged-endovascular-repair-of-critical-limb-ischemia-in-high-risk-patients-the-procedural-and-clinical-outcomes
#10
Guang Liu, Chaoyi Cui, Minyi Yin, Kaichuang Ye, Xaiobing Liu, Jinbao Qin, Huihua Shi, Xintian Huang, Min Lu, Xinwu Lu, Weimin Li, Mier Jiang
PURPOSE: To retrospectively evaluate the procedural and clinical outcomes after staged angioplasty in high-risk, chronic, critical limb ischemia (CLI) patients. METHODS: Between 2013 and 2015, 29 patients (29 limbs) (mean age 77 years) were treated by staged revascularization procedures in (i) the iliac artery-DFA alone or with the femoropopliteal artery followed by (ii) the femoropopliteal artery and a below-the-knee artery. All patients had long-segment iliofemoral artery and below-the-knee artery (TASCII D) occlusions with abnormal serum myoglobin and ischemic lesions...
September 7, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28882806/modulatory-effect-of-different-doses-of-%C3%AE-1-3-1-6-glucan-on-the-expression-of-antioxidant-inflammatory-stress-and-immune-related-genes-of-oreochromis-niloticus-challenged-with-streptococcus-iniae
#11
Abdallah S Salah, Abeer F El Nahas, Shawky Mahmoud
β-glucans are widely-known immunostimulants that are profusely used in aquaculture industry. The present study was conducted to evaluate the effect of different in-feed doses of β-1,3/1,6-glucans on the expression of antioxidant and stress-related genes (GST, HSP-70, Vtg), inflammation related genes (Il-8, TNFα, CXC-chemokine and CAS) and adaptive immune-related genes (MHC-IIβ, TLR-7, IgM-H, and Mx) of Oreochromis niloticus challenged and non-challenged with Streptococcus iniae. Six experimental groups were established: non-challenged control (non-supplemented diet), challenged control (non-supplemented diet), non-challenged supplemented with 0...
September 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#12
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28861085/neurotrophin-receptor-p75ntr-regulates-immune-function-of-plasmacytoid-dendritic-cells
#13
Joanna Bandoła, Cornelia Richter, Martin Ryser, Arshad Jamal, Michelle P Ashton, Malte von Bonin, Matthias Kuhn, Benjamin Dorschner, Dimitra Alexopoulou, Katrin Navratiel, Ingo Roeder, Andreas Dahl, Christian M Hedrich, Ezio Bonifacio, Sebastian Brenner, Sebastian Thieme
Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, for the first time, the expression and immune-regulatory function of the low affinity neurotrophin receptor p75 neurotrophin receptor (p75NTR) by the antigen-presenting pDCs, mediated by toll-like receptor (TLR) 9 activation and differential phosphorylation of interferon regulatory factor 3 and 7...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28857295/a-protective-role-of-irf3-and-irf7-signaling-downstream-tlrs-in-the-development-of-vein-graft-disease-via-type-i-interferons
#14
K H Simons, H A B Peters, J Wouter Jukema, M R de Vries, P H A Quax
BACKGROUND: Toll like receptors (TLR) play an important role in vein graft disease (VGD). Interferon regulatory factors (IRF) 3 and 7 are the transcriptional regulators of type-I interferons (IFN) and type-I IFN responsive genes and are downstream factors of TLRs. Relatively little is known with regard to the interplay of IRFs and TLRs in VGD development. The aim of this study was to investigate the role of IRF3 and IRF7 signaling downstream TLRs and the effect of IRF3 and IRF7 in VGD...
August 31, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28856441/toll-like-receptor-5-and-7-expression-may-impact-prognosis-of-hpv-positive-oropharyngeal-squamous-cell-carcinoma-patients
#15
Lauri Jouhi, Hesham Mohamed, Antti Mäkitie, Satu Maria Remes, Caj Haglund, Timo Atula, Jaana Hagström
A large subset of oropharyngeal squamous cell carcinomas (OPSCCs) is associated with HPV infection and has better outcome than non-viral-related tumors. Various malignancies also carry a role for TLRs, key activators of inflammation and innate immunity. We examined the expression of TLRs in OPSCC, and their association with HPV status and treatment outcome. TLR 5, 7, 9, and p16 were studied by immunohistochemistry and HPV status was detected with in situ hybridization in 202 tumors of consecutively treated OPSCC patients using tissue microarray method...
August 30, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28854856/first-clinical-experience-with-the-multi-loc-multiple-stent-delivery-system-for-focal-stenting-in-long-femoro-popliteal-lesions
#16
Klaus Amendt, Ulrich Beschorner, Matthias Waliszewski, Martin Sigl, Ralf Langhoff, Jörg Thalwitzer, Ulf Redlich, Britta Vogel, Dirk Härtel, Thomas Zeller
Background: The purpose of this observational study is to report the six-month clinical outcomes with a new multiple stent delivery system in patients with femoro-popliteal lesions. Patients and methods: The LOCOMOTIVE study is an observational multicentre study with a primary endpoint target lesion revascularization (TLR) rate at six months. Femoro-popliteal lesions were prepared with uncoated and/or paclitaxel-coated peripheral balloon catheters. When flow limiting dissections, elastic recoil or recoil due to calcification required stenting, up to six short stents per delivery device, each 13 mm in length, were implanted...
August 31, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28844484/tlr2-arg677trp-but-not-tlr2-196-to-174-ins-del-and-arg753gln-polymorphism-alter-the-risk-of-peptic-ulcer-in-north-of-iran
#17
Maryam Habibzadeh, Mehdi Tourani, Javad Shokri-Shirvani, Amrollah Mostafazadeh, Soraya Khafri, Hamid Reza Nouri
BACKGROUND: Most polymorphisms that occur in TLR-2 are associated with gastrointestinal disorders such as peptic ulcer disease (PUD). Hence, in current study, association between TLR2-196 to -174 ins/del, Arg753Gln and Arg677Trp polymorphisms and risk of PUD development in north of Iran was evaluated. METHODS: This case-control study included 50 patients with PUD as cases and 50 people without peptic ulcer as control group. Blood and endoscopic biopsies were collected...
August 22, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28843340/human-tlr-gene-family-members-are-differentially-expressed-in-patients-with-urothelial-carcinoma-of-the-bladder
#18
Seda Sabah-Ozcan, Aykut Baser, Taha Olcucu, Ikbal Cansu Barıs, Levent Elmas, Levent Tuncay, Saadettin Eskicorapci, Nilay Sen Turk, Vildan Caner
PURPOSE: Toll-like receptors (TLRs) have an important role in the activation of both innate and adaptive immunity in response to pathogens and endogenous danger signals from damaged or dying cells. The aim of this study was to determine the relationship between urothelial carcinoma (UC) and TLR expression. BASIC PROCEDURES: Real-time polymerase chain reaction evaluation was made of the messenger RNA expression of TLRs 1-10 in 24 UC samples and 46 nontumoral bladder tissue samples...
August 23, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28841289/nanoscale-zeolitic-imidazolate-framework-8-as-efficient-vehicles-for-enhanced-delivery-of-cpg-oligodeoxynucleotides
#19
Huijie Zhang, Wei Chen, Kai Gong, Jinghua Chen
CpG oligodeoxynucleotides (ODNs) activate the immune system and induce Th 1 responses by stimulation of Toll-like receptor 9 (TLR9). Thus, CpG ODNs have become immunotherapeutics against various diseases including cancers, allergies, and infection. However, applications of CpG ODNs are largely limited because of their easy degradation by DNase as well as inefficient cellular uptake. Development of efficient delivery systems capable of transferring CpG ODNs into immune cells is important to enhance their therapeutic efficacy...
September 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28831740/expression-of-mir-155-associated-with-toll-like-receptors-3-7-and-9-transcription-in-the-olfactory-bulbs-of-cattle-naturally-infected-with-bhv5
#20
Bruna R S M Oliveira, Flavia V Vieira, Dielson de S Vieira, Sergio E L da Silva, Roberto Gameiro, Eduardo F Flores, Tereza C Cardoso
Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly through the olfactory pathway. The innate immune response triggered by the host face to virus replication through the olfactory route is poorly understood. Recently, an upregulation of conserved pathogen-associated molecular pattern, as Toll-like receptors (TLRs), has been demonstrated in the CNS of BHV5 experimentally infected cows...
August 22, 2017: Journal of Neurovirology
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