Gijsje J L J Snijders, Katia de Paiva Lopes, Marjolein A M Sneeboer, Benjamin Z Muller, Frederieke A J Gigase, Ricardo A Vialle, Roy Missall, Raphael Kubler, Towfique Raj, Jack Humphrey, Lot D de Witte
UNLABELLED: Microglia, the immune cells of the brain, are increasingly implicated in neurodegenerative disorders through genetic studies. However, how genetic risk factors for these diseases are related to microglial gene expression, microglial function, and ultimately disease, is still largely unknown. Microglia change rapidly in response to alterations in their cellular environment, which is regulated through changes in transcriptional programs, which are as yet poorly understood. Here, we compared the effects of a set of inflammatory and restorative stimuli (lipopolysaccharide, interferon-gamma, resiquimod, tumor necrosis factor-alpha, adenosine triphosphate, dexamethasone, and interleukin-4) on human microglial cells from 67 different donors (N = 398 samples) at the gene and transcript level...
October 13, 2023: bioRxiv