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https://www.readbyqxmd.com/read/29353101/amyloid-pathology-in-the-progression-to-mild-cognitive-impairment
#1
Philip S Insel, Oskar Hansson, R Scott Mackin, Michael Weiner, Niklas Mattsson
The objective of this study was to determine the cognitive and functional decline and development of brain injury in individuals progressing from preclinical (β-amyloid positive cognitively normal) to prodromal Alzheimer's disease (AD) (β-amyloid positive mild cognitive impairment [MCI]), and compare this with individuals who progress to MCI in the absence of significant amyloid pathology. Seventy-five cognitively healthy participants who progressed to MCI were followed for 4 years on average and up to 10 years...
December 27, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29352978/use-of-multimodality-imaging-and-artificial-intelligence-for-diagnosis-and-prognosis-of-early-stages-of-alzheimer-s-disease
#2
REVIEW
Xiaonan Liu, Kewei Chen, Teresa Wu, David Weidman, Fleming Lure, Jing Li
Alzheimer's disease (AD) is a major neurodegenerative disease and the most common cause of dementia. Currently, no treatment exists to slow down or stop the progression of AD. There is converging belief that disease-modifying treatments should focus on early stages of the disease, that is, the mild cognitive impairment (MCI) and preclinical stages. Making a diagnosis of AD and offering a prognosis (likelihood of converting to AD) at these early stages are challenging tasks but possible with the help of multimodality imaging, such as magnetic resonance imaging (MRI), fluorodeoxyglucose-positron emission topography (PET), amyloid-PET, and recently introduced tau-PET, which provides different but complementary information...
January 10, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29352855/risk-of-progression-from-subjective-cognitive-decline-to-mild-cognitive-impairment-the-role-of-study-setting
#3
Beth E Snitz, Tianxiu Wang, Yona Keich Cloonan, Erin Jacobsen, Chung-Chou H Chang, Tiffany F Hughes, M Ilyas Kamboh, Mary Ganguli
INTRODUCTION: We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. METHODS: Older adults presenting at a memory clinic were classified as SCD (n = 113) or as noncomplainers (n = 82). Participants from a population study were classified as SCD (n = 592) and noncomplainers (n = 589) based on a memory complaint score. Annual follow-up performed for 3 years...
January 17, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29352259/plasma-mcp-1-and-cognitive-decline-in-patients-with-alzheimer-s-disease-and-mild-cognitive-impairment-a-two-year-follow-up-study
#4
Wei-Ju Lee, Yi-Chu Liao, Yen-Feng Wang, I-Feng Lin, Shuu-Jiun Wang, Jong-Ling Fuh
Monocyte chemoattractant protein-1 (MCP-1, also known as chemokine CCL2) is a vital chemokine that mediates inflammation in Alzheimer's disease (AD). We analyzed the associations between the baseline plasma MCP-1 level, longitudinal cognitive changes, and genetic effects of CCL2 rs1024611 and its receptor, CC-chemokine receptor 2 (CCR2) rs1799864, in AD. In total, 310 AD patients and 66 mild cognitive impairment (MCI) patients were followed for 2 years, and 120 controls were recruited at baseline for comparison...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348375/-suspected-non-alzheimer-s-disease-pathophysiology-snap-and-its-pathological-backgrounds-in-the-diagnosis-of-preclinical-and-clinical-alzheimer-s-disease
#5
Masahito Yamada
Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker-based condition that is found in individuals with normal levels of amyloid-β protein (Aβ) markers (A-) and abnormal levels of markers of neurodegeneration or neuronal injury (N+). SNAP is found in 20-26% of cognitively normal (CN) individuals aged 65 years or older and 17-35% of individuals with mild cognitive impairment (MCI). Similarly, 7-39% of patients with clinically probable Alzheimer's disease (AD) dementia are negative for Aβ...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29347228/dynamics-of-spinning-particle-pairs-in-a-single-layer-complex-plasma-crystal
#6
V Nosenko, S K Zhdanov, H M Thomas, J Carmona-Reyes, T W Hyde
Spontaneous formation of spinning pairs of particles, or torsions, is studied in a single-layer complex plasma crystal by reducing the discharge power at constant neutral gas pressure. At higher gas pressures, torsions spontaneously form below a certain power threshold. Further reduction of the discharge power leads to the formation of multiple torsions. However, at lower gas pressures the torsion formation is preceded by mode-coupling instability (MCI). The crystal dynamics are studied with the help of the fluctuation spectra of crystal particles' in-plane velocities...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29344924/reliability-of-the-123i-mibg-heart-mediastinum-ratio-results-of-a-multicenter-test-retest-reproducibility-study
#7
Timothy M Bateman, Karthikeyan Ananthasubramaniam, Daniel S Berman, Myron Gerson, Robert Gropler, Milena Henzlova, Fernando Mendoza, Michael Miyamoto, Mahesh Shah, Frederick Weiland
A quantitative measurement, the Heart-to-Mediastinum (H/M) ratio of counts derived from a planar acquisition approximately 4 hours after injection of 123I-mIBG, is a strong predictor of outcomes in patients with stable class II-III heart failure and LVEF ≤ 35%. This study assessed the test-retest reproducibility of the H/M ratio in such patients. 47 subjects with class II-III systolic heart failure and LVEF ≤ 35% were tested at two time intervals separated by 5 to 14 days. Subjects were imaged twice on the same camera using the same radionuclide dose...
January 17, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29343753/procalcitonin-as-a-biomarker-for-malignant-cerebral-edema-in-massive-cerebral-infarction
#8
Yan Zhang, Gang Liu, Yuan Wang, Yingying Su, Rehana K Leak, Guodong Cao
The objective of this study is to explore whether procalcitonin (PCT) can serve as an early biomarker of malignant cerebral edema in patients with massive cerebral infarction (MCI). Ninety-three patients with acute MCI were divided into death or survival groups based on whether they died or survived within 1 week of cerebral herniation. Differences in laboratory parameters between these two groups were analyzed by univariate analysis, followed by multivariate logistic regression analyses if the influencing factors were significantly different...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343651/determining-patient-selection-tool-and-response-predictor-for-outpatient-30-mci-radioiodine-ablation-dose-in-non-metastatic-differentiated-thyroid-carcinoma-a-japanese-perspective
#9
Tetsuya Higuchi, Arifudin Achmad, Duong Duc Binh, Anu Bhattarai, Yoshito Tsushima
The lack of isolation ward throughout Japan has long been limiting the 131I radioactive iodine (RAI) ablation for differentiated thyroid cancer (DTC) cases. The 30 mCi RAI ablation was only recently permitted for outpatient basis. However, no patient selection tool nor response predictor has been proposed. This study evaluated factors to find response predictor and determinant for the suitable patients. The retrospective study reviewed 47 eligible non-metastatic papillary DTC patients whose had first 30 mCi RAI ablation after total thyroidectomy...
January 16, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29343175/activity-based-goals-generated-by-older-adults-with-mild-cognitive-impairment
#10
Juleen Rodakowski, Amanda M Becker, Katlyn W Golias
Client-centered care is one promising rehabilitation model that may support the unique needs of older adults with mild cognitive impairment (MCI). This secondary analysis examined (a) whether older adults with MCI generated activity-based goals using a client-centered model and (b) the types of goals generated. Thirteen older adults with MCI addressed 55 goals. Using client-centered care, the participants generated goals despite subtle limitations in activities and participation. Participants generated the greatest number of goals related to instrumental activities of daily living...
January 1, 2018: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/29341070/personality-changes-during-the-transition-from-cognitive-health-to-mild-cognitive-impairment
#11
Richard J Caselli, Blake T Langlais, Amylou C Dueck, Bruce R Henslin, Travis A Johnson, Bryan K Woodruff, Charlene Hoffman-Snyder, Dona E C Locke
BACKGROUND/OBJECTIVES: Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether personality changes that predispose to behavioral disorders arise during the transition from preclinical AD to mild cognitive impairment (MCI). DESIGN: Longitudinal observational cohort study...
January 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29338921/faster-progression-from-mci-to-probable-ad-for-carriers-of-a-single-nucleotide-polymorphism-associated-with-type-2-diabetes
#12
Hugo Girard, Olivier Potvin, Scott Nugent, Caroline Dallaire-Théroux, Stephen Cunnane, Simon Duchesne
Sporadic Alzheimer's disease (AD), as opposed to its autosomal dominant form, is likely caused by a complex interaction of genetic, environmental, and health lifestyle factors. Twin studies indicate that sporadic AD heritability could be between 58% and 79%, around half of which is explained by the ε4 allele of the apolipoprotein E (APOE4). We hypothesized that genes associated with known risk factors for AD, namely hypertension, hypercholesterolemia, obesity, diabetes, and cardiovascular disease, would contribute significantly to the remaining heritability...
December 7, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29335040/does-a-cognitive-stress-test-predict-progression-from-mild-cognitive-impairment-to-dementia-equally-well-in-clinical-versus-population-based-settings
#13
Joanne C Beer, Beth E Snitz, Chung-Chou H Chang, David A Loewenstein, Mary Ganguli
BACKGROUND: Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive impairment (MCI) to dementia in both a clinical and a population-based sample. METHODS: Participants with MCI in the clinical (n = 184) and population-based (n = 435) samples were followed for up to four years...
January 16, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29334684/aberrant-connectivity-in-mild-cognitive-impairment-and-alzheimer-disease-revealed-by-multimodal-neuroimaging-data
#14
Qing Li, Xia Wu, Fufang Xie, Kewei Chen, Li Yao, Jiacai Zhang, Xiaojuan Guo, Rui Li
BACKGROUND: Making use of multimodal data simultaneously to understand the neural mechanism of mild cognitive impairment (MCI) has been in the focus nowadays. The simultaneous use of multimodal data can take advantage of each modality which may only provide the view of one specific aspect of the brain. OBJECTIVE: To this end, the present study used structural magnetic resonance imaging (sMRI), fluorodeoxyglucose positron emission tomography (FDG-PET) and florbetapir PET to reveal the integrated brain network between MCI and normal controls (NCs)...
January 13, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29334638/the-effectiveness-of-physical-exercise-on-cognitive-and-psychological-outcomes-in-individuals-with-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#15
REVIEW
Dan Song, Doris S F Yu, Polly W C Li, Yang Lei
OBJECTIVE: Individuals with mild cognitive impairment (MCI) are at high risk for developing dementia. Physical exercise is a promising intervention for cognitive decline. Systematic reviews regarding the effects of physical exercise on cognitive and psychological outcomes among MCI patients are limited, and a systematic review exploring the effects of exercise modalities on the results has not been conducted. This study evaluated the effects of physical exercise on cognitive and psychological outcomes for MCI patients and attempted to identify which specific modality of exercise is more effective...
January 4, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29333462/assessment-of-ultrasound-radio-guided-occult-lesion-localization-in-non-palpable-breast-lesions
#16
Seyed Ali Alamdaran, Donia Farokh, Ayda Sharifi Haddad, Navid Daghighi, Elaheh Modoodi, Ramin Sadeghi, Mohammad Naser Forghani, Asieh Sadat Fattahi
Objectives: Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasound- and radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29332043/serum-non-ceruloplasmin-non-albumin-copper-elevation-in-mild-cognitive-impairment-and-dementia-due-to-alzheimer-s-disease-a-case-control-study
#17
Luca Rozzini, Francesco Lanfranchi, Andrea Pilotto, Simona Catalani, Maria Enrica Gilberti, Matteo Paganelli, Pietro Apostoli, Alessandro Padovani
Several studies showed high serum copper levels in Alzheimer's disease (AD). The present study applied a newly developed method to detect serum copper free from proteins (free-Cu). Forty-four patients affected by dementia due to AD, thirty-six patients affected by mild cognitive impairment (MCI) due to AD, and twenty-eight healthy controls underwent clinical, cognitive, and MRI assessment. The new method showed higher free-Cu concentrations in MCI and dementia due to AD compared to controls (p < 0.0001)...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29332036/relationships-between-lower-olfaction-and-brain-white-matter-lesions-in-elderly-subjects-with-mild-cognitive-impairment
#18
Juliette Heinrich, Jean-Sébastien Vidal, Axelle Simon, Anne-Sophie Rigaud, Olivier Hanon, Jacques Epelbaum, Cecile Viollet, Emmanuelle Duron
BACKGROUND: Olfactory impairment is reported in mild cognitive impairment (MCI) and Alzheimer's disease (AD) and is associated with hippocampal atrophy. In elderly people, dementia with AD neuropathology and white matter lesions (WML) is common. In this context, olfactory impairment could also depend on the presence of WML. OBJECTIVE: To assess the cross-sectional relationship between olfaction and WML in elderly subjects with MCI. METHODS: Consecutive subjects, >65 years old, diagnosed as MCI after a comprehensive neuropsychological assessment in an expert memory center, with a brain MRI performed within a year and without major depressive state, were included...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331848/repetitive-transcranial-magnetic-stimulation-for-apathy-in-mild-cognitive-impairment-a-double-blind-randomized-sham-controlled-cross-over-pilot-study
#19
Prasad R Padala, Kalpana P Padala, Shelly Y Lensing, Andrea N Jackson, Cassandra R Hunter, Christopher M Parkes, Richard A Dennis, Melinda M Bopp, Ricardo Caceda, Mark S Mennemeier, Paula K Roberson, Dennis H Sullivan
Apathy is a common and disabling behavioral concomitant of many neurodegenerative conditions. The presence of apathy with Mild Cognitive Impairment (MCI) is linked with heightened rates of conversion to Alzheimer's disease. Improving apathy may slow the neurodegenerative process. The objective was to establish the efficacy of repetitive transcranial magnetic stimulation (rTMS) in improving apathy in older adults with MCI. An 8-week, double-blind, randomized, sham-controlled cross-over study was conducted in nine subjects (66 ± 9 years) with apathy and MCI...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29326289/prevalence-of-hippocampal-enlarged-perivascular-spaces-in-a-sample-of-patients-with-hypertension-and-their-relation-with-vascular-risk-factors-and-cognitive-function
#20
Joan Jiménez-Balado, Iolanda Riba-Llena, Edurne Garde, Marta Valor, Belen Gutiérrez, Francesc Pujadas, Pilar Delgado
OBJECTIVES: The clinical importance of hippocampal enlarged perivascular spaces (H-EPVS) remains uncertain. We aimed to study their association with vascular risk factors, cognitive function and mild cognitive impairment (MCI). METHODS: Data were obtained from the ISSYS (Investigating Silent Strokes in hYpertensives, a magnetic resonance imaging Study) cohort, which is a prospective study of patients with hypertension aged 50-70 with no prior stroke or dementia...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
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