keyword
MENU ▼
Read by QxMD icon Read
search

Mci

keyword
https://www.readbyqxmd.com/read/27921991/the-role-of-depression-in-the-insomnia-of-people-with-subjective-memory-impairment-mild-cognitive-impairment-and-dementia-in-a-community-sample-of-elderly-individuals-in-south-korea
#1
Won-Hyoung Kim, Ji-Hyun Kim, Byung-Soo Kim, Sung-Man Chang, Dong-Woo Lee, Maeng-Je Cho, Jae-Nam Bae
BACKGROUND: This study investigates the relationship between insomnia and cognitive dysfunctions including, subjective memory impairment (SMI), mild cognitive impairment (MCI), and dementia, by considering depression in a community sample of elderly individuals. METHODS: Data for 1,740 elderly individuals aged 65 years and over were obtained from a nationwide dementia epidemiological study conducted in South Korea. Cognitive functional status was assessed by the Mini-Mental State Examination and the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet Clinical Assessment Battery...
December 6, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27921357/interrelationship-between-mini-mental-state-examination-scores-and-biochemical-parameters-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease
#2
Ramasamy Vasantharekha, Hannah P Priyanka, Thangavel Swarnalingam, Avathvadi Venkatesan Srinivasan, Srinivasan ThyagaRajan
AIM: The aim of the present study was to provide first-hand information about the prevalence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tamil Nadu, a southern state in India, and examine if there exists a relationship between cognitive functions and biochemical parameters in these patients. METHODS: Surveys were collected from adults, older men and women (n = 3126) from different regions of Tamil Nadu, which were followed up after 12 months for 1337 participants...
December 6, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27920794/dance-experience-and-associations-with-cortical-gray-matter-thickness-in-the-aging-population
#3
Shai Porat, Naira Goukasian, Kristy S Hwang, Theodore Zanto, Triet Do, Jonathan Pierce, Shantanu Joshi, Ellen Woo, Liana G Apostolova
INTRODUCTION: We investigated the effect dance experience may have on cortical gray matter thickness and cognitive performance in elderly participants with and without mild cognitive impairment (MCI). METHODS: 39 cognitively normal and 48 MCI elderly participants completed a questionnaire regarding their lifetime experience with music, dance, and song. Participants identified themselves as either dancers or nondancers. All participants received structural 1.5-tesla MRI scans and detailed clinical and neuropsychological evaluations...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27917496/time-trends-of-contact-allergy-to-the-european-baseline-series-in-lithuania
#4
Kotryna Linauskienė, Laura Malinauskienė, Audra Blažienė
BACKGROUND: Monitoring trends of positive patch test reactions is useful for epidemiological surveillance and contact allergy prevention, and has not previously been reported in Lithuania. OBJECTIVES: To examine and compare changes in the prevalence of contact allergy to European baseline series allergens in adults with suspected contact dermatitis during a 9-year period. METHODS: In this retrospective study, patch test results of 297 consecutive patients, tested with the European baseline series in 2014-2015, were analysed and compared with the data published earlier in Lithuania...
December 4, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27917121/neurochemical-and-neuroanatomical-plasticity-following-memory-training-and-yoga-interventions-in-older-adults-with-mild-cognitive-impairment
#5
Hongyu Yang, Amber M Leaver, Prabha Siddarth, Pattharee Paholpak, Linda Ercoli, Natalie M St Cyr, Harris A Eyre, Katherine L Narr, Dharma S Khalsa, Helen Lavretsky
Behavioral interventions are becoming increasingly popular approaches to ameliorate age-related cognitive decline, but their underlying neurobiological mechanisms and clinical efficiency have not been fully elucidated. The present study explored brain plasticity associated with two behavioral interventions, memory enhancement training (MET) and a mind-body practice (yogic meditation), in healthy seniors with mild cognitive impairment (MCI) using structural magnetic resonance imaging (s-MRI) and proton magnetic resonance spectroscopy ((1)H-MRS)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27916816/blueberry-consumption-affects-serum-uric-acid-concentrations-in-older-adults-in-a-sex-specific-manner
#6
Carol L Cheatham, Itzel Vazquez-Vidal, Amanda Medlin, V Saroja Voruganti
Blueberries are rich in antioxidants and may protect against disease. Uric acid accounts for about 50% of the antioxidant properties in humans. Elevated levels of serum uric acid (SUA) or hyperuricemia is a risk factor for cardiovascular disease (CVD). The aim was to determine the effect of blueberries on SUA in older adults. Participants (n = 133, 65-80 years) experiencing mild cognitive impairment (MCI) were randomized in a double-blind 6-month clinical trial to either blueberry or placebo. A reference group with no MCI received no treatment...
November 29, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27915993/directed-functional-connectivity-of-posterior-cingulate-cortex-and-whole-brain-in-alzheimer-s-disease-and-mild-cognitive-impairment
#7
Enyan Yu, Zhengluan Liao, Dewang Mao, Qi Zhang, Gongjun Ji, Yumei Li, Zhongxiang Ding
BACKGROUND: Impaired functional connectivity in the default mode network (DMN) is supposedly involved in Alzheimer's disease (AD) progression. The posterior cingulate cortex (PCC) might be an imaging marker for monitoring AD progression. OBJECTIVE: To investigate the alterations in the directed functional connectivity between the PCC and whole brain in patients with AD, patients with mild cognitive impairment (MCI), and healthy controls. METHODS: A total of 116 enrolled participants were divided into three groups: AD (n=32), MCI (n=26), and controls (n=58)...
December 1, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27915992/plasma-phospholipids-are-associated-with-mild-cognitive-impairment-in-type-2-diabetic-patients
#8
Jin-Biao Zhang, Yan-Nan Cong, Zhen-Guang Li, Hai-Rong Sun, Jiang-Shan Zhang, Peng-Fei Wang, Qi-Zhan Wu
Phospholipids (PLs) and their metabolisms are closely allied to nosogenesis and aggravation of Type 2 diabetes mellitus and cognitive impairment. The aim of this study is to characterize the plasma levels of phospholipids in type 2 diabetes patients and type 2 diabetes patients with mild cognitive impairment (MCI), and to identify potential biomarkers of type 2 diabetes patients with MCI. In this cross-sectional study, A total of 374 type 2 diabetes patients were prospectively enrolled. There were 103 patients with MCI and 271 patients without MCI (control)...
December 1, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27914848/falls-cognitive-impairment-and-gait-performance-results-from-the-good-initiative
#9
Gilles Allali, Cyrille P Launay, Helena M Blumen, Michele L Callisaya, Anne-Marie De Cock, Reto W Kressig, Velandai Srikanth, Jean-Paul Steinmetz, Joe Verghese, Olivier Beauchet
OBJECTIVES: Falls are highly prevalent in individuals with cognitive decline. The complex relationship between falls and cognitive decline (including both subtype and severity of dementia) and the influence of gait disorders have not been studied. This study aimed to examine the association between the subtype (Alzheimer disease [AD] versus non-AD) and the severity (from preclinical to moderate dementia) of cognitive impairment and falls, and to establish an association between falls and gait parameters during the course of dementia...
November 30, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27911340/dementia-predictors-in-parkinson-disease-a-validation-study
#10
Julius Bm Anang, Takashi Nomura, Silvia Rios Romenets, Kenji Nakashima, Jean-Francois Gagnon, Ronald B Postuma
In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27911329/comparison-of-model-based-indices-of%C3%A2-cerebral-autoregulation-and-vasomotor-reactivity-using-transcranial-doppler-versus-near-infrared-spectroscopy-in%C3%A2-patients-with-amnestic-mild-cognitive-impairment
#11
Vasilis Z Marmarelis, Dae C Shin, Takashi Tarumi, Rong Zhang
We recently introduced model-based "physiomarkers" of dynamic cerebral autoregulation and CO2 vasomotor reactivity as an aid for diagnosis of early-stage Alzheimer's disease (AD) [1], where significant impairment of dynamic vasomotor reactivity (DVR) was observed in early-stage AD patients relative to age-matched controls. Milder impairment of DVR was shown in patients with amnestic mild cognitive impairment (MCI) using the same approach in a subsequent study [2]. The advocated approach utilizes subject-specific data-based models of cerebral hemodynamics to quantify the dynamic effects of resting-state changes in arterial blood pressure and end-tidal CO2 (the putative inputs) upon cerebral blood flow velocity (the putative output) measured at the middle cerebral artery via transcranial Doppler (TCD)...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911319/autotaxin-is-related-to-metabolic-dysfunction-and-predicts-alzheimer-s-disease-outcomes
#12
Kelsey E McLimans, Auriel A Willette
BACKGROUND: Obesity and insulin resistance are associated with neuropathology and cognitive decline in Alzheimer's disease (AD). OBJECTIVE: Ecto-nucleotide pyrophosphatase/phosphodiesterase 2, also called autotaxin, is produced by beige adipose tissue, regulates metabolism, and is higher in AD prefrontal cortex (PFC). Autotaxin may be a novel biomarker of dysmetabolism and AD. METHODS: We studied Alzheimer's Disease Neuroimaging Initiative participants who were cognitively normal (CN; n = 86) or had mild cognitive impairment (MCI; n = 135) or AD (n = 66)...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911316/risk-factors-for-mild-cognitive-impairment-in-german-primary-care-practices
#13
Louis Jacob, Jens Bohlken, Karel Kostev
BACKGROUND: Mild cognitive impairment (MCI) is a common mental disorder affecting around 16% of elderly people without dementia. MCI is considered an intermediate state between normal cognition and dementia. OBJECTIVE: To analyze risk factors for the development of MCI in German primary care practices. METHODS: In total, 3,604 MCI patients and 3,604 controls without MCI were included between January 2010 and December 2015. Several disorders potentially associated with MCI were determined...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911314/updating-the-evidence-on-the-association-between-serum-cholesterol-and-risk-of%C3%A2-late-life-dementia-review-and%C3%A2-meta-analysis
#14
Kaarin J Anstey, Kimberly Ashby-Mitchell, Ruth Peters
BACKGROUND: Cohort studies have reported that midlife high total serum cholesterol (TC) is associated with increased risk of Alzheimer's disease (AD) in late-life but findings have been based on few studies and previous reviews have been limited by a lack of compatible data. OBJECTIVE: We synthesized all high quality data from cohort studies reporting on the association between total serum cholesterol measured and late-life cognitive outcomes including Alzheimer's disease (AD), vascular dementia (VaD), any dementia, mild cognitive impairment (MCI), and cognitive decline...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911297/sample-size-estimation-for-alzheimer-s-disease-trials-from-japanese-adni-serial-magnetic-resonance-imaging
#15
Motonobu Fujishima, Atsushi Kawaguchi, Norihide Maikusa, Ryozo Kuwano, Takeshi Iwatsubo, Hiroshi Matsuda
BACKGROUND: Little is known about the sample sizes required for clinical trials of Alzheimer's disease (AD)-modifying treatments using atrophy measures from serial brain magnetic resonance imaging (MRI) in the Japanese population. OBJECTIVE: The primary objective of the present study was to estimate how large a sample size would be needed for future clinical trials for AD-modifying treatments in Japan using atrophy measures of the brain as a surrogate biomarker...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911296/screening-for-mild-cognitive-impairment-and-dementia-with-automated-anonymous-online-and-telephone-cognitive-self-tests
#16
Lisa D Van Mierlo, Hans Wouters, Sietske A M Sikkes, Wiesje M Van der Flier, Niels D Prins, Jonne A E Bremer, Teddy Koene, Hein P J Van Hout
BACKGROUND: Many older people worry about cognitive decline. Early cognitive screening in an anonymous and easily accessible manner may reassure older people who are unnecessarily worried about normal cognitive aging while it may also expedite help seeking in case of suspicious cognitive decline. OBJECTIVE: To develop and validate online and telephone-based automated self-tests of cognitive function. METHODS: We examined the feasibility and validity of the self-tests in a prospective study of 117 participants of whom 34 had subjective cognitive decline (SCD), 30 had mild cognitive impairment (MCI), and 53 had dementia...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911294/deleterious-effect-of-butyrylcholinesterase-k-variant-in-donepezil-treatment-of-mild-cognitive-impairment
#17
Sophie Sokolow, Xiaohui Li, Lucia Chen, Kent D Taylor, Jerome I Rotter, Robert A Rissman, Paul S Aisen, Liana G Apostolova
BACKGROUND: Donepezil is an acetylcholinesterase inhibitor frequently prescribed for the treatment of mild cognitive impairment (MCI) though not approved by the Food and Drug Administration for this indication. In Alzheimer's disease, butyrylcholinesterase (BChE) activity increases with disease progression and may replace acetylcholinesterase function. The most frequent polymorphism of BChE is the K-variant, which is associated with lower acetylcholine-hydrolyzing activity. BChE-K polymorphism has been studied in Alzheimer's disease progression and donepezil therapy, and has led to contradictory results...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27910252/memory-performance-on-the-story-recall-test-and-prediction-of-cognitive-dysfunction-progression-in-mild-cognitive-impairment-and-alzheimer-s-dementia
#18
Jong-Hwan Park, Hyuntae Park, Sang Wuk Sohn, Sungjae Kim, Kyung Won Park
AIM: To determine the factors that influence diagnosis and differentiation of patients with mild cognitive impairment (MCI) and Alzheimer's dementia (AD) by comparing memory test results at baseline with those at 1-2-year follow up. METHODS: We consecutively recruited 23 healthy participants, 44 MCI patients and 27 patients with very mild AD according to the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorder Association criteria for probable Alzheimer's disease and Petersen's clinical diagnostic criteria...
December 1, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27909405/classifying-cognitive-profiles-using-machine-learning-with-privileged-information-in-mild-cognitive-impairment
#19
Hanin H Alahmadi, Yuan Shen, Shereen Fouad, Caroline Di B Luft, Peter Bentham, Zoe Kourtzi, Peter Tino
Early diagnosis of dementia is critical for assessing disease progression and potential treatment. State-or-the-art machine learning techniques have been increasingly employed to take on this diagnostic task. In this study, we employed Generalized Matrix Learning Vector Quantization (GMLVQ) classifiers to discriminate patients with Mild Cognitive Impairment (MCI) from healthy controls based on their cognitive skills. Further, we adopted a "Learning with privileged information" approach to combine cognitive and fMRI data for the classification task...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27909150/validity-of-the-georgian-montreal-cognitive-assessment-for-the-screening-of-mild-cognitive-impairment-and-dementia
#20
Marina Janelidze, Nina Mikeladze, Nazibrola Bochorishvili, Ann Dzagnidze, Mariam Kapianidze, Nino Mikava, Irene Khatiashvili, Darejan Kakhiani, Ekaterina Mirvelashvili, Nino Shiukashvili, Zurab Nadareishvili
Montreal Cognitive Assessment (MoCA) test has been shown to be a reliable tool to detect mild cognitive impairment (MCI), however, no Georgian language version exists. The goal of this study is to determine the validity, reliability, and accuracy of Georgian version of MoCA in the evaluation of amnestic MCI (aMCI) and Alzheimer's disease (AD). Montreal Cognitive Assessment was translated into Georgian language and was administered to healthy participants (HP) and patients with aMCI and AD. We studied 46 HS, 20 patients with aMCI, and 20 patients with AD...
November 30, 2016: American Journal of Alzheimer's Disease and Other Dementias
keyword
keyword
6956
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"