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Shinji Ouma, Midori Suenaga, Funda F Bölükbaşı Hatip, Izzettin Hatip-Al-Khatib, Yoshio Tsuboi, Yoichi Matsunaga
Objectives: To determine the relevance of Mini-Mental State Examination (MMSE), serum 25-hydroxyvitamin D (25(OH)D3), and 1,25(OH)2D3 concentrations to mild cognitive impairment (MCI) and various stages of Alzheimer's disease (AD). Materials and Methods: The study included 230 participants (>74 years) allocated to three main groups: 1-healthy subjects (HS, n  = 61), 2-patients with MCI ( n  = 61), and 3- patients with Alzheimer's disease (AD) subdivided into three stages: mild ( n  = 41), moderate ( n  = 35), and severe AD ( n  = 32)...
March 2018: Brain and Behavior
Ondrej Bezdicek, Tommaso Ballarini, Filip Růžička, Jan Roth, Karsten Mueller, Robert Jech, Matthias L Schroeter
Mild cognitive impairment (MCI) affects approximately one-third of non-demented Parkinson's Disease (PD) patients. We aimed at investigating the neural correlates of MCI in PD combining multimodal magnetic resonance imaging (MRI) with large-scale data from the literature. We analyzed 31 PD patients and 30 matched controls. The standard neuropsychological assessment of PD-MCI covered memory, attention, executive functions, language and visuospatial abilities. Following validated criteria, 16 patients were classified as showing MCI...
March 11, 2018: Neuropsychologia
Tazeen H Jafar, Ngiap Chuan Tan, John C Allen, Eric A Finkelstein, Paul Goh, Peter Moey, Joanne Hui Min Quah, Siew Wai Hwang, Juliana Bahadin, Anandan Gerard Thiagarajah, Jason Chan, Gary Kang, Agnes Koong
BACKGROUND: Hypertension is a serious public health problem in Singapore and is associated with significant morbidity and mortality from cardiovascular disease (CVD) with considerable implications for health-care resources. The goal of the trial is to compare a multicomponent intervention (MCI) to usual care to evaluate the effectiveness and cost-effectiveness of the MCI for lowering blood pressure (BP) among adults with uncontrolled hypertension in Singapore primary-care clinics. METHODS/DESIGN: The study is a cluster randomized trial in eight polyclinics in Singapore: four deliver a structured MCI and four deliver usual care...
March 14, 2018: Trials
Hyun Jun Kim, Sang Yeoup Lee, Hwa Gyeong Lee, Yang Hee Cho, Eun Mi Ko
Few studies have been undertaken to develop cognitive functional improvement-focused exercise programs and determine their effect. The objectives of this study were to evaluate the effects of a cognitive enhancement fitness program (CEFP) on short-term memory and serum brain-derived neurotrophic factor (BDNF) levels according to the cognitive state in middle-aged women. A total of 30 healthy volunteers aged 40-59 years were divided into two groups, that is, a mild cognitive impairment (MCI) group and a non-MCI group based on results from the Korean Dementia Screening Questionnaire...
March 2018: Journal of Sports Science & Medicine
Jocasta Ball, Maja-Lisa Løchen, Melinda J Carrington, Joshua F Wiley, Simon Stewart
Objective: Mild cognitive impairment (MCI) is prevalent in atrial fibrillation (AF) and has the potential to contribute to poor outcomes. We investigated the influence of MCI on survival and rehospitalisation in patients with chronic forms of AF undergoing a home-based, AF-specific disease management intervention (home-based intervention (HBI)) or standard management (SM). Methods: The Montreal Cognitive Assessment tool was administered at baseline (a score of <26/30 indicated MCI) in patients with AF randomised to HBI versus SM...
2018: Open Heart
Liping Fu, Linwen Liu, Jinming Zhang, Baixuan Xu, Yong Fan, Jiahe Tian
The aim of this study was to identify the brain networks from early-phase11 C-PIB (perfusion PIB, pPIB) data and to compare the brain networks of patients with differentiating Alzheimer's disease (AD) with cognitively normal subjects (CN) and of mild cognitively impaired patients (MCI) with CN. Forty participants (14 CN, 12 MCI, and 14 AD) underwent11 C-PIB and18 F-FDG PET/CT scans. Parallel independent component analysis (pICA) was used to identify correlated brain networks from the11 C-pPIB and18 F-FDG data, and a two-sample t -test was used to evaluate group differences in the corrected brain networks between AD and CN, and between MCI and CN...
2018: Contrast Media & Molecular Imaging
Marta Gómez-Sancho, Jussi Tohka, Vanessa Gómez-Verdejo
Alzheimer's Disease (AD) is a progressive neurological disorder in which the death of brain cells causes memory loss and cognitive decline. The identification of at-risk subjects yet showing no dementia symptoms but who will later convert to AD can be crucial for the effective treatment of AD. For this, Magnetic Resonance Imaging (MRI) is expected to play a crucial role. During recent years, several Machine Learning (ML) approaches to AD-conversion prediction have been proposed using different types of MRI features...
March 9, 2018: Magnetic Resonance Imaging
Beatrice J Edwards, Xiaotao Zhang, Ming Sun, Holly M Holmes, Leena Ketonen, Nandita Guha, Peter Khalil, Juhee Song, Shelli Kesler, Jay B Shah, Debasish Tripathy, Vicente Valero, Richard E Champlin
OBJECTIVE: To assess cognitive function in older adults undergoing cancer care. MATERIALS AND METHODS: This is a cross-sectional study, in the University of Texas MD Anderson Cancer Center, in older adults undergoing cancer care. Comprehensive geriatric assessments were conducted prior to surgery, chemotherapy or allogeneic stem cell transplantation, at the Program for Healthy Aging from January 1, 2013 through March 31, 2015. Cognitive assessment was conducted through personal and family interview, and the Montreal cognitive assessment (MoCA)...
March 9, 2018: Journal of Geriatric Oncology
Yi-Qi Lin, Sheng-Di Chen
Increasing evidence indicates a strong association between rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease - cognitive impairment (PD-CI). Numerous longitudinal and cross-sectional studies have shown that RBD may be an important risk factor and predictor of Parkinson's disease - mild cognitive impairment (PD-MCI) and Parkinson's disease dementia (PDD); which may be explained by the association of mechanisms between RBD and PD-CI, including neurotransmitter alterations, genetic mutation, neuroinflammation, alpha-synuclein inclusion, abnormal cerebral metabolism and cortical activity slowing...
April 2018: Sleep Medicine
Hikaru Oba, Teruyuki Matsuoka, Ayu Imai, Hiroshi Fujimoto, Yuka Kato, Keisuke Shibata, Kaeko Nakamura, Jin Narumoto
OBJECTIVE: To investigate the effects of interactions between memory impairment, depressive symptoms, and anosognosia. METHODS: Anosognosia for memory impairment was assessed in 118 patients with Alzheimer's disease (AD), 47 patients with mild cognitive impairment (MCI), and 17 non-diagnosed controls (NC) using a questionnaire and evaluation of the anosognosia score as the discrepancy between ratings of the patient and a relative. Demographic characteristics, such as the relationship of the patient with the relative and the activities of daily living (ADL) were evaluated...
March 12, 2018: Aging & Mental Health
Kelsey R Thomas, Joel Eppig, Emily C Edmonds, Diane M Jacobs, David J Libon, Rhoda Au, David P Salmon, Mark W Bondi
OBJECTIVE: Preclinical Alzheimer's disease (AD) defined by a positive AD biomarker in the presence of normal cognition is presumed to precede mild cognitive impairment (MCI). Subtle cognitive deficits and cognitive inefficiencies in preclinical AD may be detected through process and error scores on neuropsychological tests in those at risk for progression to MCI. METHOD: Cognitively normal participants (n = 525) from the Alzheimer's Disease Neuroimaging Initiative were followed for up to 5 years and classified as either stable normal (n = 305) or progressed to MCI (n = 220)...
February 2018: Neuropsychology
Luca Stingeni, Leonardo Bianchi, Caterina Foti, Paolo Romita, Luigi Rigano, Katharina Hansel
No abstract text is available yet for this article.
April 2018: Contact Dermatitis
Susanne G Mueller, Paul A Yushkevich, Sandhitsu Das, Lei Wang, Koen Van Leemput, Juan Eugenio Iglesias, Kate Alpert, Adam Mezher, Peter Ng, Katrina Paz, Michael W Weiner
Objective: Subfield-specific measurements provide superior information in the early stages of neurodegenerative diseases compared to global hippocampal measurements. The overall goal was to systematically compare the performance of five representative manual and automated T1 and T2 based subfield labeling techniques in a sub-set of the ADNI2 population. Methods: The high resolution T2 weighted hippocampal images (T2-HighRes) and the corresponding T1 images from 106 ADNI2 subjects (41 controls, 57 MCI, 8 AD) were processed as follows...
2018: NeuroImage: Clinical
María Díez-Cirarda, Antonio P Strafella, Jinhee Kim, Javier Peña, Natalia Ojeda, Alberto Cabrera-Zubizarreta, Naroa Ibarretxe-Bilbao
The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB)...
2018: NeuroImage: Clinical
Hayato Takeuchi, Masahiro Kameda, Takao Yasuhara, Tatsuya Sasaki, Atsuhiko Toyoshima, Jun Morimoto, Kyohei Kin, Mihoko Okazaki, Michiari Umakoshi, Ittetsu Kin, Ken Kuwahara, Yosuke Tomita, Isao Date
Several reports have shown that long-term potentiation (LTP) per se effectively enhances neurogenesis in the hippocampus of intact animals. If LTP can enhance neurogenesis in chronic hypoperfusion, this approach could potentially become a new therapeutic strategy for the restoration of cognitive function and for prevention from deterioration of mild cognitive impairment (MCI). Using an in vivo LTP model of rats, we examined whether LTP per se can enhance neurogenesis in hypoperfusion rats that underwent permanent bilateral common carotid artery occlusion (permanent 2-vessel occlusion, P2VO)...
2018: Frontiers in Aging Neuroscience
Nuria Mendoza Laiz, Sagrario Del Valle Díaz, Natalia Rioja Collado, Javier Gomez-Pilar, Roberto Hornero
BACKGROUND: Dementia is a disease that is constantly evolving in older people. Its diverse symptoms appear with varying degrees of severity affecting the daily life of those who suffer from it. The rate in which dementia progresses depends on different aspects of the treatment, chosen to try to control and slow down the development of the illness. OBJECTIVE: The aim of this study is to assess the effectiveness of cognitive training through a Brain Computer Interface (BCI) and the NeuronUp platform in two age groups whose MMSE is between 18-23 MCI (mild dementia)...
2018: Restorative Neurology and Neuroscience
Seok Jong Chung, Han Soo Yoo, Jungsu S Oh, Jae Seung Kim, Byoung Seok Ye, Young H Sohn, Phil Hyu Lee
INTRODUCTION: To investigate the relationship between the sub-regional pattern of striatal dopamine depletion and cognitive impairment in early-stage Parkinson's disease (PD), and determine the effect of striatal dopamine density on cognitive prognosis. METHODS: Patients with drug-naïve non-demented PD were divided into mild cognitive impairment (PD-MCI; n = 129) and cognitively normal (PD-CogN; n = 182) groups. Using quantification of the dopamine transporter (DAT) availability in each striatal sub-region with18 F-FP-CIT PET scans, we performed inter-group comparative analysis of DAT availability and multivariate linear regression analysis to assess the association between DAT availability and cognitive performance...
March 2, 2018: Parkinsonism & related Disorders
Li Yang, Qing-Hua Zou, Yan Zhang, Yin Shi, Chun-Rong Hu, Cai-Xia Hui, Xiao-Fei Liu, Yong-Fei Fang
Rheumatoid arthritis (RA) patients may suffer from comorbid neuropsychiatric symptoms including mild cognitive impairment (MCI). Although comorbidity of MCI is common, there are currently no validated plasma biomarkers to aid MCI diagnosis. This study screened plasma from patients with RA with and without comorbid MCI to identify potential biomarkers useful in the differential diagnosis of comorbid MCI. Plasma samples were collected from patients with RA without comorbid MCI, with comorbid MCI, and from healthy controls...
March 10, 2018: Clinical Rheumatology
Ka-Ngo Leung, James K Leung, Graeme Melville
Compact neutron generators can provide high flux of neutrons with energies ranging from thermal (0.025 eV) to 14 MeV. Recent measurements demonstrated high neutron yields from the D-7 Li fusion reaction at an interaction energy of 500 keV. Using the D-7 Li reaction and applying new advancements in high flux neutron generator technology along with the commercial availability of high voltage DC power supplies enables the production of useful quantities of radioisotopes for medical applications. Using the known neutron reaction cross-sections, it has been estimated that hundreds-to-thousands MBq (or tens-to-hundreds mCi) of99 Mo,225 Ac,64 Cu and67 Cu can be obtained from a compact high flux neutron generator...
March 7, 2018: Applied Radiation and Isotopes
Zhen Fan, Melanie Dani, Grazia D Femminella, Melanie Wood, Valeria Calsolaro, Mattia Veronese, Federico Turkheimer, Steve Gentleman, David J Brooks, Rainer Hinz, Paul Edison
PURPOSE: Neuroinflammation and microglial activation play an important role in amnestic mild cognitive impairment (MCI) and Alzheimer's disease. In this study, we investigated the spatial distribution of neuroinflammation in MCI subjects, using spectral analysis (SA) to generate parametric maps and quantify11 C-PBR28 PET, and compared these with compartmental and other kinetic models of quantification. METHODS: Thirteen MCI and nine healthy controls were enrolled in this study...
March 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
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