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Adrenergic receptor inflammation

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https://www.readbyqxmd.com/read/28877454/a-stat6-pten-axis-links-regulatory-t-cells-with-adipose-tissue-function
#1
Stefanie Kälin, Maike Becker, Verena B Ott, Isabelle Serr, Fabian Hosp, Mohammad M H Mollah, Susanne Keipert, Daniel Lamp, Francoise Rohner-Jeanrenaud, Victoria K Flynn, Martin G Scherm, Lucas F R Nascimento, Katharina Gerlach, Vanessa Popp, Sarah Dietzen, Tobias Bopp, Purna Krishnamurthy, Mark H Kaplan, Manuel Serrano, Stephen C Woods, Philipp Tripal, Ralf Palmisano, Martin Jastroch, Matthias Blüher, Christian Wolfrum, Benno Weigmann, Anette-Gabriele Ziegler, Matthias Mann, Matthias H Tschöp, Carolin Daniel
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction...
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28874462/%C3%AE-arrestin2-improves-post-myocardial-infarction-heart-failure-via-sarco-endo-plasmic-reticulum-ca-2-atpase-dependent-positive-inotropy-in-cardiomyocytes
#2
Katie A McCrink, Jennifer Maning, Angela Vu, Malika Jafferjee, Christine Marrero, Ava Brill, Ashley Bathgate-Siryk, Samalia Dabul, Walter J Koch, Anastasios Lymperopoulos
Heart failure is the leading cause of death in the Western world, and new and innovative treatments are needed. The GPCR (G protein-coupled receptor) adapter proteins βarr (β-arrestin)-1 and βarr-2 are functionally distinct in the heart. βarr1 is cardiotoxic, decreasing contractility by opposing β1AR (adrenergic receptor) signaling and promoting apoptosis/inflammation post-myocardial infarction (MI). Conversely, βarr2 inhibits apoptosis/inflammation post-MI but its effects on cardiac function are not well understood...
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28838539/mirna-deregulation-in-cardiac-aging-and-associated-disorders
#3
Robin Verjans, Marc van Bilsen, Blanche Schroen
The prevalence of age-related diseases is increasing dramatically, among which cardiac disease represents the leading cause of death. Aging of the heart is characterized by various molecular and cellular hallmarks impairing both cardiomyocytes and noncardiomyocytes, and resulting in functional deteriorations of the cardiac system. The aging process includes desensitization of β-adrenergic receptor (βAR)-signaling and decreased calcium handling, altered growth signaling and cardiac hypertrophy, mitochondrial dysfunction and impaired autophagy, increased programmed cell death, low-grade inflammation of noncanonical inflammatory cells, and increased ECM deposition...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28753658/neuroanatomy-of-the-spleen-mapping-the-relationship-between-sympathetic-neurons-and-lymphocytes
#4
Kaitlin Murray, Dayn Romero Godinez, Ingrid Brust-Mascher, Elaine Nicole Miller, Melanie G Gareau, Colin Reardon
The nervous system plays a profound regulatory role in maintaining appropriate immune responses by signaling to immune cells. These immune cells, including B- and T-cells, can further act as intermediary messengers, with subsets of B- and T-cells expressing choline acetyltransferase (ChAT), the enzyme required for acetylcholine (ACh) synthesis. Neural control of ACh release from ChAT+ T-cells can have powerful immune implications, regulating lymphocyte trafficking, inflammation, and prevent death due to experimental septic shock...
2017: PloS One
https://www.readbyqxmd.com/read/28740379/peg-coated-gold-nanoparticles-attenuate-%C3%AE-adrenergic-receptor-mediated-cardiac-hypertrophy
#5
Yuhui Qiao, Baoling Zhu, Aiju Tian, Zijian Li
Gold nanoparticles (AuNPs) are widely used as a drug delivery vehicle, which can accumulate in the heart through blood circulation. Therefore, it is very important to understand the effect of AuNPs on the heart, especially under pathological conditions. In this study, we found that PEG-coated AuNPs attenuate β-adrenergic receptor (β-AR)-mediated acute cardiac hypertrophy and inflammation. However, both isoproterenol, a non-selective β-AR agonist, and AuNPs did not induce cardiac function change or cardiac fibrosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28724493/oral-transmucosal-detomidine-gel-in-new-zealand-white-rabbits-oryctolagus-cuniculus
#6
Morika D Williams, C Tyler Long, Jessica R Durrant, Gabriel P McKeon, Heather R Shive, Emily H Griffith, Kristen M Messenger, Richard E Fish
Handling and restraining rabbits for routine procedures may be impossible without prior sedation, result in unnecessary stress or injury to the rabbit or handler, and increase experimental variability. Parenteral administration of sedatives can cause stress also, as well as localized pain and tissue damage, especially in fractious animals. Detomidine hydrochloride, an α2-adrenergic receptor agonist, is commercially available in an oral transmucosal (OTM) gel formulation that is FDA-approved for sedation and restraint in horses...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28687335/a-genome-wide-transcriptomic-analysis-of-articular-cartilage-during-normal-maturation-in-pigs
#7
Naga Suresh Adapala, Harry K W Kim
OBJECTIVE: The articular cartilage undergoes dramatic changes in structure and composition during post-natal maturation, but the associated transcriptional changes are not well characterized. Compared to a mature stage, the immature articular cartilage shows developmental features such as increased thickness, presence of blood vessels, and the presence of a deep layer of growth cartilage which undergoes endochondral ossification. These features decrease during normal development. Following maturation, the articular cartilage is known to undergo few minor modifications...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28646990/%C3%AE-2-adrenergic-receptors-in-inflammation-and-vascular-complications-of-diabetes
#8
Daniel L Galvan, Farhad R Danesh
The cross talk between the immune and nervous systems is critical not only for maintaining normal homeostasis but also for the progression of a variety of inflammatory diseases. Macrophage activation and β2-adrenergic receptors are known to play important roles in facilitating this communication between these 2 systems. Using an integrated in vitro and in vivo study, Noh et al. reveal that β2-adrenergic receptor agonists exhibit protective effects against the vascular complications of diabetes. The protective effects of β2-adrenergic receptor agonists seem to be dependent on a β-arrestin2/inhibitor of kappa B/nuclear factor-κB signaling pathway...
July 2017: Kidney International
https://www.readbyqxmd.com/read/28624610/anti-fc%C3%AE-riib-monoclonal-antibody-suppresses-murine-igg-dependent-anaphylaxis-by-fc-domain-targeting-of-fc%C3%AE-riii
#9
Corey D Clay, Richard T Strait, Ashley Mahler, Marat V Khodoun, Fred D Finkelman
BACKGROUND: The inhibitory receptor, FcγRIIB, is expressed on human and murine bone marrow-derived cells and limits inflammation by suppressing signaling through stimulatory receptors. OBJECTIVE: Evaluate the effects of K9.361, a mouse IgG2a alloantibody to mouse FcγRIIB, on murine anaphylaxis. METHODS: Wild-type and FcγR-deficient mice were used to study anaphylaxis, which was induced by injection of 2.4G2 (rat IgG2b mAb that binds both FcγRIIB and the stimulatory receptor, FcγRIII); by actively immunizing IgE-deficient mice, then challenging with the immunizing Ag; and by passive immunization with IgG or IgE anti-TNP mAb, followed by injection of TNP-ovalbumin...
June 14, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28621257/oral-transmucosal-detomidine-gel-in-new-zealand-white-rabbits-oryctolagus-cuniculus
#10
Morika D Williams, C Tyler Long, Jessica R Durrant, Gabriel P McKeon, Heather R Shive, Emily H Griffith, Kristen M Messenger, Richard E Fish
Handling and restraining rabbits for routine procedures may be impossible without prior sedation, result in unnecessarystress or injury to the rabbit or handler, and increase experimental variability. Parenteral administration of sedatives can cause stress also, as well as localized pain and tissue damage, especially in fractious animals. Detomidine hydrochloride, an α2-adrenergic receptor agonist, is commercially available in an oral transmucosal (OTM) gel formulation that is FDA-approved for sedation and restraint in horses...
June 15, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28555511/mitigation-of-inflammation-using-the-intravenous-anesthetic-dexmedetomidine-in-the-mouse-air-pouch-model
#11
Takefumi Inada, Chisato Sumi, Kiichi Hirota, Koh Shingu, Akihisa Okamoto, Yoshiyuki Matsuo, Takahiko Kamibayashi
Dexmedetomidine, an α2-adrenergic/imidazoline receptor agonist, is a widely used intravenous anesthetic. Its primary current usage is for sedation of patients in the intensive care unit. The mouse air pouch model is versatile in studying the anti-inflammatory effect of a drug on a local inflammation, which is induced by a variety of substances. In the present study, using the carrageenan-induced air pouch inflammation model, we tested whether dexmedetomidine mitigates inflammation occurring locally in the mouse air pouch...
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28554511/induction-of-cardiac-dysfunction-in-developing-and-adult-zebrafish-by-chronic-isoproterenol-stimulation
#12
Mandy Kossack, Selina Hein, Lonny Juergensen, Mauro Siragusa, Alexander Benz, Hugo A Katus, Patrick Most, David Hassel
Zebrafish is a widely used model to evaluate genetic variants and modifiers that can cause heart muscle diseases. Surprisingly, the β-adrenergic receptor (β-AR) pathway in zebrafish is not well characterized, although abnormal β-AR signaling is a major contributor to human heart failure (HF). Chronic β-AR activation in the attempt to normalize heart function in the failing heart results in a reduction of the β-ARs expression and receptor desensitization, largely mediated through G-protein coupled receptor kinase 2 (GRK2) upregulation...
May 26, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28549109/il-18-cleavage-triggers-cardiac-inflammation-and-fibrosis-upon-%C3%AE-adrenergic-insult
#13
Han Xiao, Hao Li, Jing-Jing Wang, Jian-Shu Zhang, Jing Shen, Xiang-Bo An, Cong-Cong Zhang, Ji-Min Wu, Yao Song, Xin-Yu Wang, Hai-Yi Yu, Xiang-Ning Deng, Zi-Jian Li, Ming Xu, Zhi-Zhen Lu, Jie Du, Wei Gao, Ai-Hua Zhang, Yue Feng, You-Yi Zhang
Aims: Rapid over-activation of β-adrenergic receptor (β-AR) upon stress leads to cardiac inflammation, a prevailing factor that underlies heart injury. However, mechanisms by which acute β-AR stimulation induce cardiac inflammation still remain unknown. Here, we set out to identify the crucial role of inflammasome/interleukin (IL)-18 in initiating and maintaining cardiac inflammatory cascades upon β-AR insult. Methods and results: Male C57BL/6 mice were injected with a single dose of β-AR agonist, isoproterenol (ISO, 5 mg/kg body weight) or saline subcutaneously...
May 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28544341/synthesized-enone-fatty-acids-resembling-metabolites-from-gut-microbiota-suppress-macrophage-mediated-inflammation-in-adipocytes
#14
Ha-Eun Yang, Yongjia Li, Akira Nishimura, Huei-Fen Jheng, Ana Yuliana, Ryuji Kitano-Ohue, Wataru Nomura, Nobuyuki Takahashi, Chu-Sook Kim, Rina Yu, Nahoko Kitamura, Si-Bum Park, Shigenobu Kishino, Jun Ogawa, Teruo Kawada, Tsuyoshi Goto
SCOPE: Recent reports indicate that gut microbiota and their metabolite may regulate inflammatory conditions, including the chronic inflammation of obese adipose tissues, in the host. In this study, we investigated whether specific synthesized fatty acids, identical to the metabolites generated by gut microbiota, act as anti-inflammatory factors in inflammation-induced obesity. METHODS AND RESULTS: We first used lipopolysaccharide-stimulated RAW 264.7 macrophages to examine the anti-inflammatory effect of fatty acids synthesized to resemble representative polyunsaturated fatty acid metabolites from gut microbiota...
May 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28533737/the-alpha-1a-adrenergic-receptor-agonist-a61603-reduces-cardiac-polyunsaturated-fatty-acid-and-endocannabinoid-metabolites-associated-with-inflammation-in-vivo
#15
Monte S Willis, Amro Ilaiwy, Megan D Montgomery, Paul C Simpson, Brian C Jensen
INTRODUCTION: Alpha-1-adrenergic receptors (α1-ARs) are G-protein coupled receptors (GPCRs) with three highly homologous subtypes (α1A, α1B, and α1D). Of these three subtypes, only the α1A and α1B are expressed in the heart. Multiple pre-clinical models of heart injury demonstrate cardioprotective roles for the α1A. Non-selective α1-AR activation promotes glycolysis in the heart, but the functional α1-AR subtype and broader metabolic effects have not been studied. OBJECTIVES: Given the high metabolic demands of the heart and previous evidence indicating benefit from α1A activation, we chose to investigate the effects of α1A activation on the cardiac metabolome in vivo...
October 2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28472396/chronic-activation-of-hypothalamic-oxytocin-neurons-improves-cardiac-function-during-left-ventricular-hypertrophy-induced-heart-failure
#16
Kara Garrott, Jhansi Dyavanapalli, Edmund Cauley, Mary Kate Dwyer, Sarah Kuzmiak-Glancy, Xin Wang, David Mendelowitz, Matthew W Kay
Aims: A distinctive hallmark of heart failure (HF) is autonomic imbalance, consisting of increased sympathetic activity, and decreased parasympathetic tone. Recent work suggests that activation of hypothalamic oxytocin (OXT) neurons could improve autonomic balance during HF. We hypothesized that a novel method of chronic selective activation of hypothalamic OXT neurons will improve cardiac function and reduce inflammation and fibrosis in a rat model of HF. Methods and results: Two groups of male Sprague-Dawley rats underwent trans-ascending aortic constriction (TAC) to induce left ventricular (LV) hypertrophy that progresses to HF...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28440455/%C3%AE-adrenoceptor-mediated-enhanced-inducibility-of-atrial-fibrillation-in-a-canine-system-inflammation-model
#17
Ying-Ying Chen, Ze-Wei Sun, Jian-Ping Jiang, Xiao-Dong Kang, Lin-Lin Wang, Yue-Liang Shen, Xu-Dong Xie, Liang-Rong Zheng
The exact mechanism associated with inflammation and atrial fibrillation (AF) remains unknown. The aim of the present study was to investigate the roles of connexin 43 (Cx43) and a1‑adrenergic receptor (α1‑AR) activation in the pathogenesis of system inflammation‑induced AF. A canine model of chronic low‑grade system inflammation was established by administrating a low dose of lipopolysaccharide (LPS; 0.1 µg/kg) for 2 weeks. Programmed stimulation was applied on the right atrial appendage to determine the effective refractory periods (ERP) and the window of vulnerability (WOV)...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28439935/neonatal-immune-challenge-followed-by-adult-immune-challenge-induces-epigenetic-susceptibility-to-aggravated-visceral-hypersensitivity
#18
J E Aguirre, J H Winston, S K Sarna
BACKGROUND: Abdominal pain is one of the major symptoms of inflammatory Bowel Disease (IBD). The inflammatory mediators released by colon inflammation are known to sensitize the afferent neurons, which is one of the contributors to abdominal pain. However, not all IBD patients have abdominal pain, and some patients report abdominal pain during remission, suggesting contributions of other pathological factors to abdominal pain in IBD. Epidemiological studies found early-life gastrointestinal infections a risk factor for IBD symptoms and adult-life gastrointestinal infections may trigger the onset of IBD...
September 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28416795/neutrophil-stunning-by-metoprolol-reduces-infarct-size
#19
Jaime García-Prieto, Rocío Villena-Gutiérrez, Mónica Gómez, Esther Bernardo, Andrés Pun-García, Inés García-Lunar, Georgiana Crainiciuc, Rodrigo Fernández-Jiménez, Vinatha Sreeramkumar, Rafael Bourio-Martínez, José M García-Ruiz, Alfonso Serrano Del Valle, David Sanz-Rosa, Gonzalo Pizarro, Antonio Fernández-Ortiz, Andrés Hidalgo, Valentín Fuster, Borja Ibanez
The β1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. The prevailing view has been that metoprolol acts mainly on cardiomyocytes. Here, we demonstrate that metoprolol reduces reperfusion injury by targeting the haematopoietic compartment. Metoprolol inhibits neutrophil migration in an ADRB1-dependent manner. Metoprolol acts during early phases of neutrophil recruitment by impairing structural and functional rearrangements needed for productive engagement of circulating platelets, resulting in erratic intravascular dynamics and blunted inflammation...
April 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28398147/salmeterol-a-long-acting-%C3%AE-2-adrenergic-receptor-agonist-inhibits-macrophage-activation-by-lipopolysaccharide-from-porphyromonas-gingivalis
#20
Monika Sharma, Lindsay Patterson, Elisha Chapman, Patrick M Flood
BACKGROUND: Salmeterol is a long-acting β2-adrenergic receptor agonist used to treat chronic obstructive pulmonary disease. The authors of the current study previously showed that preincubation of primary microglial-enriched cells with salmeterol could inhibit the inflammatory response induced by Escherichia coli lipopolysaccharide (LPS), a Toll-like receptor (TLR)-4 agonist. In this study, the authors sought to determine if salmeterol had a similar inhibitory effect on the inflammatory response of the murine macrophage cell line RAW264...
July 2017: Journal of Periodontology
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