keyword
MENU ▼
Read by QxMD icon Read
search

Adrenergic receptor inflammation

keyword
https://www.readbyqxmd.com/read/29733849/dexmedetomidine-restores-septic-renal-function-via-promoting-inflammation-resolution-in-a-rat-sepsis-model
#1
Rongzong Qiu, Weifeng Yao, Haocong Ji, Dongdong Yuan, Xiaofeng Gao, Weiping Sha, Fei Wang, Pinjie Huang, Ziqing Hei
BACKGROUND: Acute kidney injury occurred after sepsis, resulting in high mortality. This research aims to elucidate the mechanistic effect of DEX on the renal inflammation resolution during sepsis in rats. METHODS: The rats were randomly divided into a sham group and the other three cecal ligation and puncture (CLP) model groups, based on different treatments: placebo, DEX and 2-adrenergic receptor (AR) inhibitor atipamezole (AT) treatment (DEX + AT) groups...
May 4, 2018: Life Sciences
https://www.readbyqxmd.com/read/29729264/dexmedetomidine-attenuates-renal-fibrosis-via-%C3%AE-2-adrenergic-receptor-dependent-inhibition-of-cellular-senescence-after-renal-ischemia-reperfusion
#2
Qijian Li, Chaojin Chen, Xi Chen, Mingming Han, Juan Li
BACKGROUND: Renal ischemia/reperfusion (IR) can induce acute kidney injury (AKI), which often progresses to chronic kidney disease (CKD). Dexmedetomidine (Dex), a highly selective α2 adrenergic receptor (α2-AR) agonist, protects against acute renal IR-induced injury. However, the effects of Dex on the transition of AKI to CKD remain unclear. Therefore, we investigated the mechanisms of Dex on renal fibrosis. METHODS: Adult male C57BL/6 mice were pretreated with Dex, a specific α2A-adrenergic receptor (AR) blocker (BRL-44408), or a cell senescence inhibitor (rapamycin) in a surgical bilateral renal IR model...
May 2, 2018: Life Sciences
https://www.readbyqxmd.com/read/29727618/s-nitrosylation-of-%C3%AE-arrestins-biases-receptor-signaling-and-confers-ligand-independence
#3
Hiroki Hayashi, Douglas T Hess, Rongli Zhang, Keiki Sugi, Huiyun Gao, Bea L Tan, Dawn E Bowles, Carmelo A Milano, Mukesh K Jain, Walter J Koch, Jonathan S Stamler
Most G protein-coupled receptors (GPCRs) signal through both heterotrimeric G proteins and β-arrestins (βarr1 and βarr2). Although synthetic ligands can elicit biased signaling by G protein- vis-à-vis βarr-mediated transduction, endogenous mechanisms for biasing signaling remain elusive. Here we report that S-nitrosylation of a novel site within βarr1/2 provides a general mechanism to bias ligand-induced signaling through GPCRs by selectively inhibiting βarr-mediated transduction. Concomitantly, S-nitrosylation endows cytosolic βarrs with receptor-independent function...
May 3, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29715464/spermidine-spermine-n1-acetyltransferase-mediated-polyamine-catabolism-regulates-beige-adipocyte-biogenesis
#4
Fang Yuan, Lin Zhang, Yang Cao, Wei Gao, Can Zhao, Yuan Fang, Kamyar Zahedi, Manoocher Soleimani, Xiang Lu, Zhuyuan Fang, Qin Yang
OBJECTIVE: Cold and β3-adrenergic receptor (AR) agonists activate beige adipocyte biogenesis in white adipose tissue (WAT). The two stimuli also induce expression of inflammatory cytokines in WAT. The low-grade inflammation may further promote WAT browning. However, the mechanisms to reconcile these two biological processes remain to be elucidated. In this study, we aim to investigate the roles of the rate-limiting polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (SAT1) in regulating beige adipocyte biogenesis and inflammation...
April 28, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29692363/jak-tgf%C3%AE-cross-talk-links-transient-adipose-tissue-inflammation-to-beige-adipogenesis
#5
Rohollah Babaei, Maximilian Schuster, Irina Meln, Sarah Lerch, Rayane A Ghandour, Didier F Pisani, Irem Bayindir-Buchhalter, Julia Marx, Shuang Wu, Gabriele Schoiswohl, Adrian T Billeter, Damir Krunic, Jan Mauer, Yun-Hee Lee, James G Granneman, Lars Fischer, Beat P Müller-Stich, Ez-Zoubir Amri, Erin E Kershaw, Mathias Heikenwälder, Stephan Herzig, Alexandros Vegiopoulos
The transient activation of inflammatory networks is required for adipose tissue remodeling including the "browning" of white fat in response to stimuli such as β3-adrenergic receptor activation. In this process, white adipose tissue acquires thermogenic characteristics through the recruitment of so-called beige adipocytes. We investigated the downstream signaling pathways impinging on adipocyte progenitors that promote de novo formation of adipocytes. We showed that the Jak family of kinases controlled TGFβ signaling in the adipose tissue microenvironment through Stat3 and thereby adipogenic commitment, a function that was required for beige adipocyte differentiation of murine and human progenitors...
April 24, 2018: Science Signaling
https://www.readbyqxmd.com/read/29678287/novel-mechanisms-of-g-protein-coupled-receptors-functions-at-1-angiotensin-receptor-acts-as-a-signaling-hub-and-focal-point-of-receptor-cross-talk
#6
REVIEW
András D Tóth, Gábor Turu, László Hunyady, András Balla
AT1 angiotensin receptor (AT1 R), a prototypical G protein-coupled receptor (GPCR), is the main receptor, which mediates the effects of the renin-angiotensin system (RAS). AT1 R plays a crucial role in the regulation of blood pressure and salt-water homeostasis, and in the development of pathological conditions, such as hypertension, heart failure, cardiovascular remodeling, renal fibrosis, inflammation, and metabolic disorders. Stimulation of AT1 R leads to pleiotropic signal transduction pathways generating arrays of complex cellular responses...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29661693/phosphorylation-of-beta-3-adrenergic-receptor-at-serine-247-by-erk-map-kinase-drives-lipolysis-in-obese-adipocytes
#7
Shangyu Hong, Wei Song, Peter-James H Zushin, Bingyang Liu, Mark P Jedrychowski, Amir I Mina, Zhaoming Deng, Dimitrije Cabarkapa, Jessica A Hall, Colin J Palmer, Hassan Aliakbarian, John Szpyt, Steven P Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S Banks
OBJECTIVE: The inappropriate release of free fatty acids from obese adipose tissue stores has detrimental effects on metabolism, but key molecular mechanisms controlling FFA release from adipocytes remain undefined. Although obesity promotes systemic inflammation, we find activation of the inflammation-associated Mitogen Activated Protein kinase ERK occurs specifically in adipose tissues of obese mice, and provide evidence that adipocyte ERK activation may explain exaggerated adipose tissue lipolysis observed in obesity...
March 29, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29652832/sympathetic-nerve-hyperactivity-in-the-spleen-causal-for-nonpathogenic-driven-chronic-immune-mediated-inflammatory-diseases-imids
#8
REVIEW
Denise L Bellinger, Dianne Lorton
Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic group of diseases or conditions that share common inflammatory pathways, and for which there is no definitive etiology. IMIDs affect the elderly most severely, with many older individuals having two or more IMIDs. These diseases include, but are not limited to, type-1 diabetes, obesity, hypertension, chronic pulmonary disease, coronary heart disease, inflammatory bowel disease, and autoimmunity, such as rheumatoid arthritis (RA), Sjőgren's syndrome, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and multiple sclerosis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29599420/brown-adipose-tissue-whitening-leads-to-brown-adipocyte-death-and-adipose-tissue-inflammation
#9
Petra Kotzbeck, Antonio Giordano, Eleonora Mondini, Incoronata Murano, Ilenia Severi, Wiebe Venema, Maria Paola Cecchini, Erin E Kershaw, Giorgio Barbatelli, Guenter Haemmerle, Rudolf Zechner, Saverio Cinti
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content and activity decline in obese subjects, mainly as a result of the conversion of brown adipocytes to white-like unilocular cells. Here, we show that BAT ″whitening″ is induced by multiple factors, including high ambient temperature, leptin receptor deficiency, beta-adrenergic signaling impairment, and lipase deficiency, each of which is capable of inducing macrophage infiltration, brown adipocyte death, and crown-like structure (CLS) formation...
March 29, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29580170/comparison-of-therapeutic-triiodothyronine-versus-metoprolol-in-treatment-of-myocardial-infarction-in-rats
#10
Kuo Zhang, Yi-Da Tang, Youhua Zhang, Kaie Ojamaa, Ying Li, Amandeep Singh Saini, Maria Alicia Carrillo-Sepulveda, Viswanathan Rajagopalan, A Martin Gerdes
BACKGROUND: Beta blockers are standard therapy for myocardial infarction (MI). Preclinical studies have shown efficacy and safety of thyroid hormone (TH) treatment of cardiovascular disorders. Since THs interact with the sympathoadrenergic system, we aimed to compare triiodothyronine (T3) and metoprolol (Met) treatment of rats with MI on pathophysiology and TH-adrenergic signaling. METHODS: Female Sprague-Dawley rats aged 12 weeks underwent left anterior descending coronary artery ligation (MI) or sham surgeries...
March 26, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29541878/neural-pathways-involved-in-infection-induced-inflammation-recent-insights-and-clinical-implications
#11
REVIEW
Marion Griton, Jan Pieter Konsman
Although the immune and nervous systems have long been considered independent biological systems, they turn out to mingle and interact extensively. The present review summarizes recent insights into the neural pathways activated by and involved in infection-induced inflammation and discusses potential clinical applications. The simplest activation concerns a reflex action within C-fibers leading to neurogenic inflammation. Low concentrations of pro-inflammatory cytokines or bacterial fragments may also act on these afferent nerve fibers to signal the central nervous system and bring about early fever, hyperalgesia and sickness behavior...
March 14, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29523072/neuroprotective-dobutamine-treatment-upregulates-superoxide-dismutase-3-anti-oxidant-and-survival-genes-and-attenuates-genes-mediating-inflammation
#12
Tina Markus, David Ley, Stefan R Hansson, Tadeusz Wieloch, Karsten Ruscher
BACKGROUND: Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects against hypoxia/aglycemia induced neuronal damage. We aimed to identify the associated protective biological processes involved. RESULTS: Hippocampal slices from 6 days old mice showed significant changes of gene expression comparing slices with or without dobutamine (50 mM) in the following two experimental paradigms: (1) control conditions versus lipopolysacharide (LPS) stimulation and (2) oxygen-glucose deprivation (OGD), versus combined LPS/OGD...
March 9, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29496881/%C3%AE-2-adrenergic-receptor-mediated-negative-regulation-of-group-2-innate-lymphoid-cell-responses
#13
Saya Moriyama, Jonathan R Brestoff, Anne-Laure Flamar, Jesper B Moeller, Christoph S N Klose, Lucille C Rankin, Naomi A Yudanin, Laurel A Monticelli, Gregory Garbès Putzel, Hans-Reimer Rodewald, David Artis
The type 2 inflammatory response is induced by various environmental and infectious stimuli. Although recent studies identified group 2 innate lymphoid cells (ILC2s) as potent sources of type 2 cytokines, the molecular pathways controlling ILC2 responses are incompletely defined. Here we demonstrate that murine ILC2s express the β2 -adrenergic receptor (β2 AR) and colocalize with adrenergic neurons in the intestine. β2 AR deficiency resulted in exaggerated ILC2 responses and type 2 inflammation in intestinal and lung tissues...
March 2, 2018: Science
https://www.readbyqxmd.com/read/29493068/derangements-in-adrenergic-adipokine-signalling-establish-a-neurohormonal-basis-for-obesity-related-heart-failure-with-a-preserved-ejection-fraction
#14
REVIEW
Milton Packer
Among patients with heart failure and a preserved ejection (HFpEF), obesity is associated with a distinct phenotype that is characterized by adiposity-driven plasma volume expansion and cardiac overfilling, which is coupled with an impairment of ventricular distensibility. These pathophysiological abnormalities may be related to the increased actions of specific adipocyte-derived signalling molecules (aldosterone, neprilysin and leptin) that work in concert with increased renal sympathetic nerve traffic and activated beta2 -adrenergic receptors to promote sodium retention, microvascular rarefaction, cardiac fibrosis and systemic inflammation...
May 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29455206/a-potential-mechanism-for-immune-suppression-by-beta-adrenergic-receptor-stimulation-following-traumatic-injury
#15
Nicholas J Shubin, Tam N Pham, Kristan Lea Staudenmayer, Brodie A Parent, Qian Qiu, Grant E O'Keefe
BACKGROUND: β-Adrenergic agents suppress inflammation and may play an important role in posttraumatic infections. Mechanisms may include inhibition of MAP kinase signaling. We sought to determine whether MKP-1 contributed to catecholamine suppression of innate immunity and also wanted to know whether early catecholamine treatment after traumatic injury increases the risk of later nosocomial infection. METHODS: We performed experiments using THP-1 cells and peripheral blood mononuclear cells from healthy individuals...
February 16, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29452585/beta-2-adrenergic-receptors-increase-treg-cell-suppression-in-an-ova-induced-allergic-asthma-mouse-model-when-mice-are-moderate-aerobically-exercised
#16
Kari J Dugger, Taylor Chrisman, Sarah L Sayner, Parker Chastain, Kacie Watson, Robert Estes
BACKGROUND: The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven allergic asthma mouse model, moderate aerobic exercise increases TREG cell function in a contact-dependent manner that leads to a significant reduction in chronic inflammation and restoration of lung function. However, the mechanism, whereby exercise increases TREG function, remains unknown and was the focus of these investigations...
February 17, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29452086/ameliorative-effects-of-clonidine-on-ethanol-induced-kidney-injury-in-rats-potential-role-for-imidazoline-1-receptor
#17
Nesreen M I M Elkomy, Islam A A E-H Ibrahim, Shimaa M Elshazly, Hassan M El-Fayoumi
Chronic alcoholism is a risk factor for kidney injury. Clonidine is an α2 -adrenergic receptor/imidazoline-1 receptor agonist that can reduce blood pressure and maintain renal functions. This study aims to investigate the possible ameliorative effects of clonidine on ethanol induced kidney injury and its mechanism of action. Kidney injury was induced in rats by adding ethanol to drinking water for eight weeks. Clonidine effects on kidney functions and histopathology were measured. Moreover, phentolamine (α-adrenergic receptor antagonist), efaroxan (imidazoline-1 receptor antagonist) and rilmenidine (imidazoline-1 receptor agonist) were used to clarify the role of imidazoline-1 receptor in mediating renal ameliorative effects...
April 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29447430/aucubin-protects-against-pressure-overload-induced-cardiac-remodelling-via-the-%C3%AE-3-adrenoceptor-neuronal-nos-cascades
#18
Qing-Qing Wu, Yang Xiao, Ming-Xia Duan, Yuan Yuan, Xiao-Han Jiang, Zheng Yang, Hai-Han Liao, Wei Deng, Qi-Zhu Tang
BACKGROUND AND PURPOSE: Aucubin, the predominant component of Eucommia ulmoides Oliv., has been shown to have profound effects on oxidative stress. As oxidative stress has previously been demonstrated to contribute to acute and chronic myocardial injury, we tested the effects of aucubin on cardiac remodelling and heart failure. EXPERIMENTAL APPROACH: Initially, H9c2 cardiomyocytes and neonatal rat cardiomyocytes pretreated with aucubin (1, 3, 10, 25 and 50 μM) were challenged with phenylephrine...
May 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29414686/kynurenic-acid-and-gpr35-regulate-adipose-tissue-energy-homeostasis-and-inflammation
#19
Leandro Z Agudelo, Duarte M S Ferreira, Igor Cervenka, Galyna Bryzgalova, Shamim Dadvar, Paulo R Jannig, Amanda T Pettersson-Klein, Tadepally Lakshmikanth, Elahu G Sustarsic, Margareta Porsmyr-Palmertz, Jorge C Correia, Manizheh Izadi, Vicente Martínez-Redondo, Per M Ueland, Øivind Midttun, Zachary Gerhart-Hines, Petter Brodin, Teresa Pereira, Per-Olof Berggren, Jorge L Ruas
The role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but remains less explored in peripheral tissues. Exercise training activates kynurenine biotransformation in skeletal muscle, which protects from neuroinflammation and leads to peripheral kynurenic acid accumulation. Here we show that kynurenic acid increases energy utilization by activating G protein-coupled receptor Gpr35, which stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue...
February 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29393391/stage%C3%A2-dependent-changes-of-%C3%AE-2%C3%A2-adrenergic-receptor-signaling-in-right-ventricular-remodeling-in-monocrotaline%C3%A2-induced-pulmonary-arterial-hypertension
#20
Fengjiao Sun, Zhiqiang Lu, Yidan Zhang, Shihan Geng, Mengxi Xu, Liman Xu, Yingying Huang, Pengwei Zhuang, Yanjun Zhang
Right ventricular (RV) remodeling coupled with extensive apoptosis in response to unrestrained biomechanical stress may lead to RV failure (RVF), which is the immediate cause of death in the majority of patients with pulmonary arterial hypertension (PAH). Overexpression of β2‑adrenergic receptor (β2‑AR) signaling has been reported to induce myocardiotoxicity in patients with left heart failure. However, the role of β2‑AR signaling in the pathophysiology of PAH development has remained elusive. To address this issue, the present study investigated the changes in cardiopulmonary function and structure, as well as the expression of regulators of fibrosis and apoptosis in RVF following monocrotaline (MCT; 60 mg/kg, i...
May 2018: International Journal of Molecular Medicine
keyword
keyword
69558
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"