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Vitamin d deficience and food allergy

Michele Miraglia Del Giudice, Annalisa Allegorico
The role of vitamin D in calcium and phosphate homeostasis is well known; however, in addition to traditional functions, vitamin D modulates a variety of processes, and evidence shows that it has an important role in different allergic diseases such as asthma, atopic dermatitis, and food allergy. Vitamin D acts by binding to the vitamin D receptor, which is present in a variety of tissues; for this reason it is considered a hormone. One of the most important functions is to modulate the immune system response, both innate and adaptive, by suppressing Th2-type response and increasing natural killer cells...
November 2016: Journal of Clinical Gastroenterology
Marcus Shaker, Carina Venter
PURPOSE OF REVIEW: Food allergic reactions have become more prevalent and management of food allergies requires dietary avoidance of triggers that may place children at nutritional risk. RECENT FINDINGS: Immunoglobulin E and non-immunoglobulin E-mediated food allergies lead to dietary avoidance. Although some children outgrow food allergies or become tolerant to cooked/baked versions of the allergen, many do not. Multiple food avoidance increases the risk for inadequate nutrient intake, including protein, calcium, vitamin D, and others...
August 2016: Current Opinion in Pediatrics
Carolyn Cairncross, Cameron Grant, Welma Stonehouse, Cath Conlon, Barry McDonald, Lisa Houghton, Darryl Eyles, Carlos A Camargo, Jane Coad, Pamela von Hurst
Recent research on vitamin D in young children has expanded from bone development to exploring immunomodulatory effects. Our aim was to investigate the relationship of vitamin D status and allergic diseases in preschool-aged children in New Zealand. Dried capillary blood spots were collected from 1329 children during late-winter to early-spring for 25(OH)D measurement by LC-MS/MS. Caregivers completed a questionnaire about their child's recent medical history. Analysis was by multivariable logistic regression...
2016: Nutrients
Kate Maslin, Erin M Oliver, Karen S Scally, Josh Atkinson, Keith Foote, Carina Venter, Graham Roberts, Kate E C Grimshaw
BACKGROUND: Infants with suspected cows' milk allergy are required to follow a strict milk exclusion diet which may lead to nutritional deficiencies, especially if not supervised by a healthcare professional. The aim of this study was to assess the nutritional adequacy of a cows' milk exclusion diet in a group of UK infants over a period of 6 months. METHODS: Participants in this study are a subgroup of the Prevalence of Infant Food Allergy study, a prospective food allergy birth cohort study from the South of England...
2016: Clinical and Translational Allergy
Noor H A Suaini, Yuxia Zhang, Peter J Vuillermin, Katrina J Allen, Leonard C Harrison
Apart from its classical function in bone and calcium metabolism, vitamin D is also involved in immune regulation and has been linked to various cancers, immune disorders and allergic diseases. Within the innate and adaptive immune systems, the vitamin D receptor and enzymes in monocytes, dendritic cells, epithelial cells, T lymphocytes and B lymphocytes mediate the immune modulatory actions of vitamin D. Vitamin D insufficiency/deficiency early in life has been identified as one of the risk factors for food allergy...
August 2015: Nutrients
Maria A Slack, Princess U Ogbogu, Gary Phillips, Thomas A E Platts-Mills, Elizabeth A Erwin
BACKGROUND: Vitamin D deficiency has been associated with increased risk for severe asthma, challenge-proven food allergy, and severe atopic dermatitis. Vitamin D levels have not been reported in patients with eosinophilic esophagitis (EoE). OBJECTIVE: To determine levels of 25-hydroxyvitamin D in a cohort of patients with EoE. METHODS: Total serum 25-hydroxyvitamin D was measured using liquid chromatography with tandem mass spectroscopy in adults (n = 35) and children (n = 34) with EoE...
July 2015: Annals of Allergy, Asthma & Immunology
Chih-Yung Chiu, Shih-Yin Huang, Yu-Chieh Peng, Ming-Han Tsai, Man-Chin Hua, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: There are few studies addressing the impact of maternal vitamin D status on the vitamin D levels in offspring, their sensitization to common allergens and atopic disease development. METHODS: Children aged 0 through 4 yr from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Time series of serum 25-hydroxyvitamin D (25(OH)D) levels were measured in maternal blood before delivery, cord blood, and at age 1...
June 2015: Pediatric Allergy and Immunology
Małgorzata Strucińska, Grażyna Rowicka, Agnieszka Riahi
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammation of the skin recognised to be one of the first clinical signs of allergy. In the first years of life, epidemiological evidence has demonstrated that common causative foods of a child's diet are: cow's milk, hen's eggs, wheat and soya. Children with AD being treated with elimination diets are at risk of nutritional deficiencies that include those nutrients required for ensuring proper skin structure and function. OBJECTIVES: The aim of the study was to assess dietary intake of nutrients which affect skin condition in children with AD being treated with a milk-free diet...
2015: Roczniki Państwowego Zakładu Higieny
Rosan Meyer, Claire De Koker, Robert Dziubak, Ana-Kristina Skrapac, Heather Godwin, Kate Reeve, Adriana Chebar-Lozinsky, Neil Shah
BACKGROUND: The management of food allergy in children requires elimination of the offending allergens, which significantly contribute to micronutrient intake. Vitamin and mineral supplementation are commonly suggested as part of dietary management. However a targeted supplementation regime requires a complete nutritional assessment, which includes food diaries. Ideally these should be analysed using a computerised program, but are very time consuming. We therefore set out to evaluate current practice of vitamin and mineral supplementation in a cohort of children with non-Immunoglobulin E (IgE) mediated food allergies...
2015: Clinical and Translational Allergy
Rosan Meyer, Claire De Koker, Robert Dziubak, Heather Godwin, Gloria Dominguez-Ortega, Neil Shah
BACKGROUND: The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied. We set out to determine the dietary intake of children on an elimination diet for this food allergy and hypothesised that the type of elimination diet and the presence of a hypoallergenic formula (HF) significantly impacts on micronutrient intake. METHOD: A prospective observational study was conducted on children diagnosed with FPIGA on an exclusion diet who completed a 3 day semi-quantitative food diary 4 weeks after commencing the diet...
2014: Clinical and Translational Allergy
H Mirzakhani, A Al-Garawi, S T Weiss, A A Litonjua
Vitamin D has known effects on lung development and the immune system that may be important in the development, severity, and course of allergic diseases (asthma, eczema, and food allergy). Vitamin D deficiency is prevalent worldwide and may partly explain the increases in asthma and allergic diseases that have occurred over the last 50-60 years. In this review, we explore past and current knowledge on the effect of vitamin D on lung development and immunomodulation and present the evidence of its role in allergic conditions...
January 2015: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Ji Hyeon Baek, Youn Ho Shin, In Hyuk Chung, Hae Jung Kim, Eun-Gyong Yoo, Jung Won Yoon, Hye Mi Jee, Young Eun Chang, Man Yong Han
OBJECTIVE: To investigate the association between serum vitamin D levels, sensitization to food allergens, and the severity of atopic dermatitis in infants. STUDY DESIGN: We investigated serum 25-hydroxyvitamin D (25[OH]D) and specific immunoglobulin E levels to common or suspected food allergens in 226 infants with atopic dermatitis or food allergy. The severity of atopic dermatitis by the Scoring Atopic Dermatitis index and amount of vitamin D intake was measured in subcohort children...
October 2014: Journal of Pediatrics
Michelle B Lierl
The primary care physician is the first line of treatment for allergic rhinitis, which affects approximately one-fourth of children in the United States. There is an increasing trend toward self-management by patients or parents due to high-deductible insurance plans and the over-the-counter availability of allergy medications. The primary care physician can offer guidance on appropriate selection of medications and potential adverse effects. Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases, and studies are underway to determine whether supplementation with vitamin D is helpful for these conditions...
August 2014: Pediatric Annals
Carlo Caffarelli, Francesca Santamaria, Alessandra Vottero, Carlotta Povesi Dascola, Virginia Mirra, Francesco Sperli, Sergio Bernasconi
This review will provide new information related to pathophysiology and management of specific diseases that have been addressed by selected articles published in the Italian Journal of Pediatrics in 2013, focusing on allergology, endocrinology, gastroenterology, hypertension, infectious diseases, neonatology, neurology, nutrition and respiratory tract illnesses in children. Recommendations for interpretation of skin prick test to foods in atopic eczema, management of allergic conjunctivitis, hypertension and breastfeeding in women treated with antiepileptic drugs and healthy breakfast have been reported...
2014: Italian Journal of Pediatrics
B Le Louer, J Lemale, K Garcette, C Orzechowski, A Chalvon, J-P Girardet, P Tounian
Over the past few years, we have observed increasing consumption of inappropriate plant milks as an alternative to infant milk formula. Some families believe that foods labeled as natural are the most healthy and an appropriate nutritional choice. However, their composition does not respect European recommendations. They are always hypocaloric and protein, vitamin, and mineral concentrations are inadequate. The aim of this study was to report severe nutritional complications after inappropriate plant milk consumption...
May 2014: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Ralf G Heine
Due to the recent exponential increase in food allergies and atopic disorders, effective allergy prevention has become a public health priority in many developed regions. Important preventive strategies include the promotion of breastfeeding and vaginal deliveries, judicious use of perinatal antibiotics, as well as the avoidance of maternal tobacco smoking. Breastfeeding for at least 6 months and introduction of complementary solids from 4-6 months are generally recommended. Complex oligosaccharides in breast milk support the establishment of bifidobacteria in the neonatal gut which stimulate regulatory T lymphocyte responses and enhance tolerance development...
2014: Nestlé Nutrition Institute Workshop Series
Arturo Borzutzky, Francisca Grob, Carlos A Camargo, Alejandro Martinez-Aguayo
Atopic dermatitis (AD) affects 10% to 20% of children worldwide. Its severity may be inversely correlated with 25-hydroxyvitamin D (25OHD) levels. Although low levels of vitamin D (VD) can cause rickets in infants, VD deficiency rickets is an unusual presentation in teenagers. We report the case of a 14-year-old girl with severe AD and fish allergy since early childhood. She lived at high latitude (with less sun exposure) and, because of her atopic disorders, avoided sunlight and fish. Laboratory studies showed elevated alkaline phosphatase and parathyroid hormone levels and low serum calcium; her serum 25OHD level was <12 nmol/L...
February 2014: Pediatrics
S K Lin, J R Lambert, M L Wahlqvist
The gastrointestinal tract, including the liver and pancreas, is a complex system whose function is to process a wide range of nutrient and other products enabling their absorption as well as detoxification and excretion. During the process, food is converted into energy and into other substances that are used by cells throughout the entire body. Many diseases can affect the various organs of the gastrointestinal (GI) system and diet plays a relatively minor role in the onset of such GI diseases. Recently it has become clear that glutamine, a 'non-essential' amino acid, is important in the maintenance of intestinal mucosal metabolism, structure and function...
March 1992: Asia Pacific Journal of Clinical Nutrition
Jadwiga Ambroszkiewicz, Grażyna Rowicka, Magdalena Chełchowska, Joanna Gajewska, Małgorzata Strucińska, Teresa Laskowska-Klita
THE AIM: of this study was to assess concentrations of sclerostin and biochemical markers of bone metabolism in children with cow's milk allergy. MATERIAL AND METHODS: The study included 45 children (age range 2-6 years) with diagnosed cow`s milk allergy, who were on a dairy-free diet and under systematic medical and dietary control at the Institute of Mother and Child in Warsaw. The control group consisted of 40 healthy children (2-6 years), who did not have any symptoms of cow`s milk allergy nor any diseases influencing bone metabolism...
July 2013: Medycyna Wieku Rozwojowego
Cassandra Sova, Mary Beth Feuling, Megan Baumler, Linda Gleason, Jonathan S Tam, Heidi Zafra, Praveen S Goday
BACKGROUND: Food allergies affect up to 8% of American children. The current recommended treatment for food allergies is strict elimination of the allergens from the diet. Dietary elimination of nutrient-dense foods may result in inadequate nutrient intake and impaired growth. The purpose of this review was to critically analyze available research on the effect of an elimination diet on nutrient intake and growth in children with multiple food allergies. METHODS: A systematic review of the literature was conducted and a workgroup was established to critically analyze each relevant article...
December 2013: Nutrition in Clinical Practice
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