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Emily May Lent, Lee C B Crouse, Allison M Jackovitz, Erica E Carroll, Mark S Johnson
Nitrotriazolone (1,2,4-triazol-5-one; NTO), an insensitive, energetic material used in explosive formulations, induced testicular toxicity and oligospermia in repeated-dose oral toxicity tests in rats. To evaluate whether NTO produces additional reproductive and developmental effects, a modified extended one-generation reproductive toxicity test was conducted. Rats were provided ad libitum access to NTO in drinking water at 0-, 144-, 720-, or 3600-mg/L NTO. Treatment of the parental generation began 2 (females) and 4 (males) wk premating and continued until weaning of litters...
October 18, 2016: Journal of Toxicology and Environmental Health. Part A
Ping-Chi Hsu, Ming-Chieh Li, Yeu-Chin Lee, Pao-Lin Kuo, Yueliang Leon Guo
In 1979, more than 2000 persons ingested rice oil contaminated with polychlorinated biphenyls and polychlorinated dibenzofurans; this event was called the "Yucheng accident." An increased percentage of oligospermia, reduced ability of sperm to penetrate oocytes, and reduced percentage of male offspring were reported in Yucheng men. This study examined whether the sperm sex ratio and chromosome aneuploidy are responsible for our observed findings in Yucheng men. In 1999-2000, Yucheng men and their neighborhood referents aged 37-50 years were recruited for physical examination, followed by semen analysis...
December 2016: Chemosphere
Alpana Singh, Nusrat Jahan, Gita Radhakrishnan, B D Banerjee
INTRODUCTION: Infertility is defined as inability to conceive after 1 year of unprotected intercourse and it affects 7% of male population and 8-10% of couples. According to estimates WHO, 13-19 million couples in India are infertile. Oxidative stress is the causative factor in 25% of infertile males. AIM: To study the efficacy of antioxidant therapy on oxidative stress parameters in seminal plasma of infertile male. MATERIALS AND METHODS: Forty patients of male infertility were enrolled in study after two abnormal semen analyses reports at 2-3 weeks interval, of oligozoospermia and/or asthenozoospermia, as per WHO guide line 1999...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Craig Niederberger
No abstract text is available yet for this article.
September 2016: Journal of Urology
Haitham El Bardisi, Ahmad Majzoub, Mohamed Arafa, Ahmad AlMalki, Sami Al Said, Kareim Khalafalla, Gaby Jabbour, Moataz Basha, Abdulla Al Ansari, Edmund Sabanegh
Obesity has become a major health concern, with a prevalence rate approaching epidemic states. An inverse relationship between men's body weight and semen parameters has been observed, suggesting a favourable role for weight loss in improving fertility. This prospective study included 46 patients undergoing sleeve gastrectomy, who were investigated with semen analysis and serum hormone tests before and 12 months after surgery. Patients were divided into three groups according to their initial sperm concentration; median loss of body mass index was used as a cut-off to further classify patients according to extent of weight loss...
August 20, 2016: Reproductive Biomedicine Online
L M Zhao, H Jiang, K Hong, H C Lin, W H Tang, D F Liu, J M Mao, Y Lian, L L Ma
OBJECTIVE: To discuss the treatment options for patients with azoospermia factor (AZF) c microdeletion on Y chromosome. METHODS: One hundred and eighty three patients, who were diagnosed as AZFc microdeletion on Y chromosome in Peking University Third Hospital, were recruited in our study. In order to get better treatment option for this kind of patients, we retrospectively analyzed their clinic data including the treatment process and pregnancy outcome and found out the characteristics of their semen...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
E Will Kirby, Laura Elizabeth Wiener, Saneal Rajanahally, Karen Crowell, Robert M Coward
OBJECTIVE: To evaluate how varicocele repair (VR) impacts pregnancy (PRs) and live birth rates in infertile couples undergoing assisted reproduction wherein the male partner has oligospermia or azoospermia and a history of varicocele. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Azoospermic and oligospermic males with varicoceles and in couples undergoing assisted reproductive technology (ART) with IUI, IVF, or testicular sperm extraction (TESE) with IVF and intracytoplasmic sperm injection (ICSI)...
August 12, 2016: Fertility and Sterility
Ting Xie, Cheng-He Yu, Ye Zheng, Zhou-Cun A
OBJECTIVE: The aim of this study was to explore the association between the polymorphism G4C14-to-A4T14 in the p73 gene and male infertility with severe spermatogenesis impairment in Chinese population. STUDY DESIGN: Three hundreds and one infertile patients with severe spermatogenesis impairment (including azoospermia and severe oligospermia) and 252 fertile men were recruited in this study. The polymorphism G4C14-to-A4T14 in the p73 gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism assay...
September 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Zohreh Hojati, Fatemeh Nouri Emamzadeh, Fariba Dehghanian
BACKGROUND: Some dynamic changes occurs during spermatogenesis such as histone removal and its replacement with transition nuclear protein and protamine. These proteins are required for packing and condensation of sperm chromatin. JHDM2A is a histone demethylase that directly binds to promoter regions of Tnp1 and Prm1 genes and controls their expression by removing H3K9 at their promoters. OBJECTIVE: The association between polymorphisms of exon 12 and exon 24 in JHDM2A gene and male infertility were evaluated for the first time...
June 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
H Asare-Anane, S B Bannison, Emmanuel K Ofori, R O Ateko, A T Bawah, S D Amanquah, S Y Oppong, B B N Gandau, J B Ziem
BACKGROUND: Tobacco smoking is a public health issue and has been implicated in adverse reproductive outcomes including semen quality. Available data however provides conflicting findings. The objective of this study was to evaluate the effect of tobacco smoking on semen quality among men in Ghana. METHODS: In this study, a total of 140 subjects were recruited, comprising 95 smokers and 45 non-smokers. Smokers were further categorized into mild, moderate and heavy smokers...
2016: Reproductive Health
Jared M Bieniek, James A Kashanian, Christopher M Deibert, Ethan D Grober, Kirk C Lo, Robert E Brannigan, Jay I Sandlow, Keith A Jarvi
OBJECTIVE: To determine whether obesity affects serum and seminal measures of male reproductive potential among a multi-institutional cohort. DESIGN: Retrospective multi-institutional cohort study. SETTING: Infertility clinics. PATIENT(S): All men referred for male infertility evaluation from 2002 to 2014 (n = 4,440). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Collected reproductive parameters included hormonal (gonadotropins, T, E2, PRL) and semen analysis (ejaculate volume, sperm concentration, motility, normal morphology) data...
October 2016: Fertility and Sterility
Tianwen He, Hui Zhao, Xin Zhao, Jian Lu, Yichun Zheng, Changbin Zhang, Aihua Yin
OBJECTIVE: To establish an accurate, fast and simple screening method for AZF microdeletions using capillary technology and use it for clinical testing. METHODS: For each pair of primers, the 5' end of either forward or reverse primer was labeled with a FAM, JOE or TAMRA fluorescence dyes to establish multiplex quantitative fluorescence PCR systems for the establishment of a screening method of Y chromosome AZF microdeletions by capillary technology. The detection of Y chromosome AZF microdeletion was carried out on 725 cases of non-obstructive azoospermia, oligospermia or asthenospermia...
August 2016: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Bradford S Hoppe, Stephanie Harris, Alice Rhoton-Vlasak, Curtis Bryant, Christopher G Morris, Roi Dagan, Romaine C Nichols, William M Mendenhall, Randal H Henderson, Zuofeng Li, Nancy P Mendenhall
BACKGROUND: The present study investigates the impact of scatter dose radiation to the testis on ejaculate and sperm counts from treatment of prostate cancer with passive-scatter proton therapy. MATERIAL AND METHODS: From March 2010 to November 2014, 20 men with low- or intermediate-risk prostate cancer enrolled in an IRB-approved protocol and provided a semen sample prior to passive-scatter proton therapy and 6-12 months following treatment. Men were excluded if they had high-risk prostate cancer, received androgen deprivation therapy, were on alpha blockers (due to retrograde ejaculation) prior to treatment, had baseline sperm count <1 million, or were unable to produce a pre-treatment sample or could not provide a follow-up specimen...
July 15, 2016: Acta Oncologica
A S Vickram, A Rao Kamini, Raja Das, M Ramesh Pathy, R Parameswari, K Archana, T B Sridharan
UNLABELLED: Seminal fluid is the secretion from many glands comprised of several organic and inorganic compounds including free amino acids, proteins, fructose, glucosidase, zinc, and other scavenging elements like Mg(2+), Ca(2+), K(+), and Na(+). Therefore, in the view of development of novel approaches and proper diagnosis to male infertility, overall understanding of the biochemical and molecular composition and its role in regulation of sperm quality is highly desirable. Perhaps this can be achieved through artificial intelligence...
August 2016: Systems Biology in Reproductive Medicine
X G Liu, H Y Hu, Y H Guo, Y P Sun
Dyszoospermia due to genetic factors is the leading cause of male infertility. To explore the correlation between azoospermia factor (AZF) microdeletion of the Y chromosome and male infertility, we evaluated AZF microdeletion on the long arm of the Y chromosome in 166 infertile males and 50 fertile males using multiplex polymerase chain reactions amplification and gel electrophoresis. The results demonstrated that 28 individuals had varying degrees of microdeletion in the AZF region (16.90%); 12 out of the 76 males with azoospermia and 16 out of the 90 males with oligospermia had AZF microdeletion...
2016: Genetics and Molecular Research: GMR
Ekachai Kovavisarach, Suppasak Lorthanawanich, Pairat Muangsamran
BACKGROUND: Coitus interruptus, a common contraceptive method, has a high failure rate. Two reasons have been proposed for this: delayed withdrawal after ejaculation and presence of sperm in the pre-ejaculatory fluid. OBJECTIVE: To determine whether sperm was present in the pre-ejaculatory fluid of healthy males. MATERIAL AND METHOD: A total of 42 healthy Thai men were enrolled in the study between August 1, 2009 and November 30, 2009 at the Department of Obstetrics and Gynecology, Rajavithi Hospital...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Elham Siasi, Ahmad Aleyasin
OBJECTIVE: To analyze and evaluate 4 single nucleotide polymorphisms (SNPs)-T132903C, C109869T, T824C, and T886C- and their correlation to the idiopathic Persian (Iranian) infertile male with oligospermia and azoospermia. STUDY DESIGN: A total of 96 idiopathic infertile male patients and 100 normal fertile men (controls) were included in the study. SNP analysis was performed using Real-Time High Resolution Melt analysis (PCR-HRM). Results were confirmed using PCR-RFLP and DNA sequencing analysis...
March 2016: Journal of Reproductive Medicine
Michael Jurewicz, Bruce R Gilbert
Ultrasound imaging and angiography play a crucial role in the diagnosis and treatment of men with subfertility. The most commonly used imaging modality is ultrasound (US), which can be used for diagnostic purposes or to aid in treatment. Scrotal US can be used to document varicoceles in subfertile men in the context of difficult examination or for confirmation before treatment. Spectral Doppler, sonoelastography, and power Doppler have aided in the evaluation and treatment of azoospermia and oligospermia. They have proven useful in the detection of spermatogenesis and sperm retrieval...
June 2016: Fertility and Sterility
Burak Tek, Pinar Elçin, Matem Tunçdemir, İlhan Onaran, Hamdi Özkara, Gönül Kanıgür Sultuybek
BACKGROUND: Nuclear factor-kappa B (NF- METHODS: In order to evaluate this association, we studied the polymorphisms and sperm apoptosis rates of 114 men with idiopathic oligospermia, as well as 130 normospermic men, using PCR-RFLP and TUNEL staining methods, respectively. RESULTS: Univariate analysis revealed that heterozygous ID genotype at the NF- CONCLUSION: Our findings suggested that the heterozygosity of rs28362491 in the NF- ...
April 2016: Archives of Iranian Medicine
C-L Zhu, Q-F Xu, S-X Li, Y-C Wei, G-C Zhu, C Yang, Y-C Shi
Recently, the question of whether vitamin D exerts an effect on the pathogenic process of infertility has become the centre of attention. There are some controversial conclusions on this issue. Based on previous studies, we sought to explore the difference of serum 25-hydroxyvitamin D3 , 1,25-dihydroxyvitamin D3 levels between infertile patients and fertile men, and to find the influence on semen quality. The analysis of serum 25-hydroxyvitamin D3 level showed no significant difference between infertile patients and fertile men...
March 18, 2016: Andrologia
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