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https://www.readbyqxmd.com/read/29334712/-the-effect-of-ambient-pm-10-on-sperm-quality-in-wuhan
#1
X C Wang, X J Tian, B Ye, L Ma, Y Zhang, J Yang
Objective: To investigate the effect of exposure to particulate matter ≤10 μm in aerodynamic diameter (PM(10)) on sperm quality in different stages of sperm development. Methods: This cross-sectional study included 1 827 patients attending the reproductive medicine center in Renmin Hospital of Wuhan University during April 2013 to January 2015. Air pollution data from January 2013 to January 2015 was obtained from the database of Wuhan Municipal Environmental Protection Bureau. The generalized linear model was employed to assess the association between each exposure variables and sperm parameters for several exposure windows (0-9, 10-14, 15-69, 70-90, 0-90 days before sampling) ...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334667/lithium-a-classic-drug-in-psychiatry-improves-nilotinib-mediated-antileukemic-effects
#2
Janaína Peixoto-da-Silva, Andrana K Calgarotto, Katiucha R Rocha, Caroline Palmeira-Dos-Santos, Soraya S Smaili, Gustavo J S Pereira, Fernando V Pericole, Adriana da Silva S Duarte, Sara T O Saad, Claudia Bincoletto
Although Tyrosine kinase inhibitors (TKIs) that target Bcr-Abl play a key role in Chronic Myeloid Leukemia (CML) therapy, they do not eradicate CML-initiating cells, which lead to the emergence of drug resistance. Here we used the lithium, a GSK-3 inhibitor, to attempt to potentiate the effects of nilotinib against leukemia cells. For this purpose, a K562 leukemia cell line and bone marrow cells from untreated Chronic Myeloid Leukemia (CML) patients, prior to any exposure to TKIs, were used as a model. Our results demonstrated that the combination of lithium + nilotinib (L + N) induced K562-cell death and cleaved caspase-3 when compared to lithium or nilotinib alone, accompanied by GSK-3β phosphorylation and Bcr-Abl oncoprotein levels reduction...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334652/insight-into-the-expression-variation-of-metal-responsive-genes-in-the-seedling-of-date-palm-phoenix-dactylifera
#3
Zayneb Chaâbene, Agnieszka Rorat, Imen Rekik Hakim, Fabien Bernard, Grubb C Douglas, Amine Elleuch, Franck Vandenbulcke, Hafedh Mejdoub
Phytochelatin synthase and metallothionein gene expressions were monitored via qPCR in order to investigate the molecular mechanisms involved in Cd and Cr detoxification in date palm (Phoenix dactylifera). A specific reference gene validation procedure using BestKeeper, NormFinder and geNorm programs allowed selection of the three most stable reference genes in a context of Cd or Cr contamination among six reference gene candidates, namely elongation factor α1, actin, aldehyde dehydrogenase, SAND family, tubulin 6 and TaTa box binding protein...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29334651/effects-of-perinatal-fluoride-exposure-on-the-expressions-of-mir-124-and-mir-132-in-hippocampus-of-mouse-pups
#4
Jixiang Wang, Yuliang Zhang, Zhenzhen Guo, Rui Li, Xingchen Xue, Zilong Sun, Ruiyan Niu
To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100 mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100 mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29334643/longitudinal-determinants-of-depression-among-world-trade-center-health-registry-enrollees-14-15-years-after-the-9-11-attacks
#5
Melanie H Jacobson, Christina Norman, Angela Nguyen, Robert M Brackbill
BACKGROUND: Exposure to the September 11, 2001 (9/11) terrorist attacks has been found to be associated with posttraumatic stress disorder (PTSD) and comorbid PTSD and depression up to 10-11 years post-disaster. However, little is known about the longitudinal predictors of mental health conditions over time. METHODS: We examined longitudinal determinants of depression within strata of PTSD among 21,258 enrollees of the World Trade Center Health Registry who completed four questionnaires over 14 years of follow-up (Wave 1 in 2003-04; Wave 2 in 2005-06; Wave 3 in 2011-12; and Wave 4 in 2015-16)...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29334624/adequate-vitamin-d3-skin-synthesis-versus-erythema-risk-in-the-northern-hemisphere-midlatitudes
#6
Jakub Guzikowski, Janusz Krzyścin, Agnieszka Czerwińska, Weronika Raszewska
Health-optimum-exposure index (HOEI) is proposed to assess if the prescribed amount of vitamin D3 (target value) could be synthesized in the human skin without erythema appearance. It is defined as the ratio between the vitamin D3 quantity received during the maximum allowed outdoor exposure without erythema risk and the target value. Sunbathing is safe for HOEI>1 and 1/HOEI represents a part of minimal erythema dose (MED) necessary to obtain the target value. We examine the following targets: a vitamin D3 quantity equivalent to 1000 IU vitamin D3 taken orally, and an optimal vitamin D3 quantity defined by Krzyścin et al...
January 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29334617/chains-of-risk-for-alcohol-use-disorder-mediators-of-exposure-to-neighborhood-deprivation-in-early-and-middle-childhood
#7
Katherine J Karriker-Jaffe, Sara L Lönn, Won K Cook, Kenneth S Kendler, Kristina Sundquist
Our goal was to test a cascade model to identify developmental pathways, or chains of risk, from neighborhood deprivation in childhood to alcohol use disorder (AUD) in young adulthood. Using Swedish general population data, we examined whether exposure to neighborhood deprivation during early and middle childhood was associated with indicators of social functioning in adolescence and emerging adulthood, and whether these were predictive of AUD. Structural equation models showed exposure to neighborhood deprivation was associated with lower school achievement during adolescence, poor social functioning during emerging adulthood, and the development of AUD for both males and females...
January 12, 2018: Health & Place
https://www.readbyqxmd.com/read/29334611/understanding-complex-tribofilms-by-means-of-h3bo3-b2o3-model-glasses
#8
Fabiana Spadaro, Antonella Rossi, Shivaprakash N Ramakrishna, Emmanuel Lainé, Philip Woodward, Nicholas D Spencer
The discovery of the spontaneous reaction of boric oxides with moisture in the air to form lubricious H3BO3 films has led to great interest in the tribology of boron compounds in general. Despite this, a study of the growth kinetics of H3BO3 on a B2O3 substrate under controlled relative humidity (RH), has not yet been reported in the literature. Here, we describe the tribological properties of H3BO3-B2O3 glass systems after aging under controlled relative humidity over different lengths of time. A series of tribological tests has been performed applying a normal load of 15 N, at both room temperature and 100°C in Yubase 4 oil...
January 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29334550/chronic-hepatitis-c-virus-infection-and-subsequent-hiv-viral-load-among-women-with-hiv-initiating-antiretroviral-therapy
#9
Sarah J Willis, Stephen R Cole, Daniel Westreich, Andrew Edmonds, Christopher B Hurt, Svenja Albrecht, Kathryn Anastos, Michael Augenbraun, Margaret Fischl, Audrey L French, Aley G Kalapila, Roksana Karim, Marion G Peters, Michael Plankey, Eric C Seaberg, Phyllis C Tien, Adaora A Adimora
OBJECTIVE(S): One in four persons living with HIV is coinfected with HCV. Biological and behavioral mechanisms may increase HIV viral load among coinfected persons. Therefore, we estimated the longitudinal effect of chronic HCV on HIV suppression after ART initiation among women with HIV (WWH). DESIGN: HIV RNA was measured every six months among 441 WWH in the Women's Interagency HIV Study who initiated ART from 2000-2015. METHODS: Log-binomial regression models were used to compare the proportion of study visits with detectable HIV RNA between women with and without chronic HCV...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334549/cost-effectiveness-of-alternative-strategies-for-provision-of-hiv-pre-exposure-prophylaxis-for-people-who-inject-drugs
#10
Rui Fu, Douglas K Owens, Margaret L Brandeau
BACKGROUND: Oral HIV pre-exposure prophylaxis (PrEP) has been recommended as a means of HIV prevention among people who inject drugs (PWID) but, at current prices, is unlikely to be cost-effective for all PWID. OBJECTIVE: To determine the cost-effectiveness of alternative strategies for enrolling PWID in PrEP. DESIGN: Dynamic network model that captures HIV transmission and progression among PWID in a representative US urban center. OUTCOME MEASURES: HIV infections averted, discounted costs and quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs)...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334527/transanal-minimally-invasive-anal-canal-polyp-resection
#11
Giovanni Dapri, Anny Cadenas Fabres, Olivier Nicod, Garces Duran Rodrigo, Vinciane Muls, Marc Van Gossum
Endoscopic mucosal resection and endoscopic submucosal dissection (ESD) are operative endoscopies that have been performed since a long time. Recently, an evolution of laparoscopy called transanal minimally invasive surgery began to be popularized, and it can be adopted in the face of difficult cases for endoscopic mucosal resection/ESD. In this video, a 36-year-old woman was submitted to transanal minimally invasive surgery resection, after unsuccessful ESD, for a 2-cm polyp located anteriorly in the anal canal, just beyond the pectineal line...
January 12, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29334526/airborne-particulate-matter-human-exposure-health-effects
#12
Jonathan E Thompson
OBJECTIVE: Exposure to airborne particulate matter (PM) is estimated to cause millions of premature deaths annually. This work conveys known routes of exposure to PM and resultant health effects. METHODS: Review of available literature. RESULTS: Estimates for daily PM exposure are provided. Known mechanisms by which insoluble particles are transported and removed from the body are discussed. Biological effects of PM, including immune response, cytotoxicity, and mutagenicity are reported...
January 12, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29334525/temporal-patterns-of-exposure-to-asbestos-and-risk-of-asbestosis-an-analysis-of-a-cohort-of-asbestos-textile-workers
#13
Andrea Farioli, Francesco S Violante, Carlo La Vecchia, Eva Negri, Claudio Pelucchi, Giovanna Spatari, Paolo Boffetta, Enrico Pira
OBJECTIVE: The aim of the study was to assess the risk of asbestosis death based on the temporal pattern of exposure to asbestos. METHODS: We followed up a cohort of asbestos textile workers, employed in 1946 to 1984, until November 2013. We measured the duration of the employment, the time since last employment (TSLE), the age, and the year of first employment. Hazard ratios (HR) were estimated through multivariable Cox regression models. RESULTS: We observed 51 asbestosis deaths among 1823 workers...
January 12, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29334522/themes-in-literature-related-to-incidence-risk-and-prevention-of-cancer-in-solid-organ-transplantation-recipients-on-immunosuppressive-therapy
#14
Stefanie L Rashti
BACKGROUND: Solid-organ transplants provide a second chance to thousands of critically ill patients with end-organ failure each year. Immunosuppressants are administered to patients to prevent graft rejection of a transplanted organ, such as a heart, kidney, or liver, while placing the recipient at greater risk for infection and cancer. OBJECTIVE: The literature provides evidence of various cancers that have been found to develop in patients' posttransplantation...
January 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29334505/the-association-of-chronic-air-pollutants-with-coronary-artery-spasm-vasospastic-angina-and-endothelial-dysfunction
#15
Byoung Geol Choi, Jiwon Lee, Suhng Wook Kim, Min Woo Lee, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND: We evaluated the effect of chronic exposure to air pollutants (APs) on coronary endothelial function and significant coronary artery spasm (CAS) as assessed by intracoronary acetylcholine (ACH) provocation test. PATIENTS AND METHODS: A total of 6430 patients with typical or atypical chest pain who underwent intracoronary ACH provocation test were enrolled. We obtained data on APs from the Korean National Institute of Environmental Research (http://www...
January 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29334496/oxygen-in-the-critically-ill-friend-or-foe
#16
Elisa Damiani, Abele Donati, Massimo Girardis
PURPOSE OF REVIEW: To examine the potential harmful effects of hyperoxia and summarize the results of most recent clinical studies evaluating oxygen therapy in critically ill patients. RECENT FINDINGS: Excessive oxygen supplementation may have detrimental pulmonary and systemic effects because of enhanced oxidative stress and inflammation. Hyperoxia-induced lung injury includes altered surfactant protein composition, reduced mucociliary clearance and histological damage, resulting in atelectasis, reduced lung compliance and increased risk of infections...
January 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29334462/pot-economy-autooxidative-condensation-of-2-aryl-2-lithio-1-3-dithianes
#17
João R Vale, Tatu Rimpiläinen, Elina Sievanen, Kari Rissanen, Carlos A M Afonso, Nuno R Candeias
The autooxidative condensation of 2-aryl-2-lithio-1,3-dithianes is here reported. Treatment of 2-aryl-1,3-dithianes with n-BuLi in the absence of any electrophile leads to condensation of three molecules of 1,3-dithianes and formation of highly functionalized α-thioether ketones orthothioesters in 51-89% yields upon air exposure. The method was further expanded to benzaldehyde dithioacetals, affording corresponding orthothioesters and α-thioether ketones in 48-97% yields. The experimental results combined with density functional theory studies support a mechanism triggered by the autooxidation of 2-aryl-2-lithio-1,3-dithianes to yield a highly reactive thioester that undergoes condensation with two other molecules of 2-aryl-2-lithio-1,3-dithiane...
January 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29334430/preclinical-therapeutic-efficacy-of-the-ciprofloxacin-eluting-sinus-stent-for-pseudomonas-aeruginosa-sinusitis
#18
Do-Yeon Cho, Dong-Jin Lim, Calvin Mackey, Daniel Skinner, Christopher Weeks, Gobind S Gill, Robert W Hergenrother, William E Swords, Bradford A Woodworth
BACKGROUND: The ciprofloxacin-coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics to the sinuses. The objective of this study is to evaluate the efficacy of the CSS stent in eliminating Pseudomonas aeruginosa infection in a rabbit model of sinusitis. METHODS: A ciprofloxacin-eluting sinus stent was created by coating ciprofloxacin/Eudragit RS100 on biodegradable poly-D/L-lactic acid (2 mg). After analyzing in-vitro inhibition of P aeruginosa (PAO-1 strain) biofilm formation, a total of 8 stents (4 shams, 4 CSSs) were placed unilaterally in rabbit maxillary sinuses via dorsal sinusotomy after inducing infection for 1 week with PAO-1...
January 15, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29334416/investigating-causal-associations-between-use-of-nicotine-alcohol-caffeine-and-cannabis-a-two-sample-bidirectional-mendelian-randomization-study
#19
Karin J H Verweij, Jorien L Treur, Jacqueline M Vink
BACKGROUND AND AIMS: Epidemiological studies consistently show co-occurrence of use of different addictive substances. Whether these associations are causal or due to overlapping underlying influences remains an important question in addiction research. Methodological advances have made it possible to use published genetic associations to infer causal relationships between phenotypes. In this exploratory study, we used Mendelian randomization (MR) to examine the causality of well-established associations between nicotine, alcohol, caffeine, and cannabis use...
January 15, 2018: Addiction
https://www.readbyqxmd.com/read/29334412/stallion-semen-quality-depends-on-mhc-matching-to-teaser-mare
#20
E Jeannerat, E Marti, C Berney, F Janett, H Bollwein, H Sieme, D Burger, C Wedekind
The major histocompatibility complex (MHC) has repeatedly been found to influence mate choice of vertebrates, with MHC-dissimilar mates typically being preferred over MHC-similar mates. We used horses (Equus caballus) to test whether MHC matching also affects male investment into ejaculates after short exposure to a female. Semen characteristics varied much among stallions. Controlling for this variance with a full-factorial within-subject experimental design, we found that a short exposure to an MHC-dissimilar mare enhanced male plasma testosterone and led to ejaculates with elevated sperm numbers as compared to exposure to an MHC-similar mare...
January 15, 2018: Molecular Ecology
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