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https://www.readbyqxmd.com/read/28918610/the-role-of-tnf-%C3%AE-in-aflatoxin-b-1-induced-hepatic-toxicity-in-isolated-perfused-rat-liver-model
#1
Kazem Koohi Mohammad, Mahmoud Ghazi-Khansari, Farzad Hayati, Hamid Staji, Morteza Keywanloo, Ebrahim Shahroozian
Aflatoxin B-1 (AFB1) is one of the major mycotoxins causing food contamination. Previous studies have shown that AFB1 can induce carcinogenicity and toxic effects in the isolated perfused rat liver and these effects are associated with its metabolites and peroxidation activity. Here we surveyed whether these pathogenic effects of AFB1 are associated with TNF-α as an inflammatory cytokine in general liver damages. In this study, we used twenty male Wistar rats (250-300 g). Rats were divided into four groups...
July 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28918602/population-pharmacokinetics-and-optimal-sampling-strategy-for-model-based-precision-dosing-of-melphalan-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#2
Kana Mizuno, Min Dong, Tsuyoshi Fukuda, Sharat Chandra, Parinda A Mehta, Scott McConnell, Elias J Anaissie, Alexander A Vinks
BACKGROUND: High-dose melphalan is an important component of conditioning regimens for patients undergoing hematopoietic stem cell transplantation. The current dosing strategy based on body surface area results in a high incidence of oral mucositis and gastrointestinal and liver toxicity. Pharmacokinetically guided dosing will individualize exposure and help minimize overexposure-related toxicity. OBJECTIVE: The purpose of this study was to develop a population pharmacokinetic model and optimal sampling strategy...
September 16, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28918601/effects-of-phoxim-induced-hepatotoxicity-on-sd-rats-and-the-protection-of-vitamin-e
#3
Jing Zhang, Wentao Song, Yuecheng Sun, Anshan Shan
Currently, public pay more attention to the adverse effect of organophosphate pesticides on human and animal health and on the environment in developing nations. Vitamin E may protect the hepatocyte and increase the function of liver. The study was to investigate the effects of phoxim-induced hepatotoxicity on Sprague Dawley (SD) rats and the protection of vitamin E. SD rats received by gavage 180 mg kg(-1) (per body weight) of phoxim, 200 mg kg(-1) (per body weight) of vitamin E, and phoxim + vitamin E...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918591/platform-model-describing-pharmacokinetic-properties-of-vc-mmae-antibody-drug-conjugates
#4
Matts Kågedal, Leonid Gibiansky, Jian Xu, Xin Wang, Divya Samineni, Shang-Chiung Chen, Dan Lu, Priya Agarwal, Bei Wang, Ola Saad, Neelima Koppada, Bernard M Fine, Jin Y Jin, Sandhya Girish, Chunze Li
Antibody-drug conjugates (ADCs) developed using the valine-citrulline-MMAE (vc-MMAE) platform, consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a protease-labile vc linker. Recently, clinical data for a variety of vc-MMAE ADCs has become available. The goal of this analysis was to develop a platform model that simultaneously described antibody-conjugated MMAE (acMMAE) pharmacokinetic (PK) data from eight vc-MMAE ADCs, against different targets and tumor indications; and to assess differences and similarities of model parameters and model predictions, between different compounds...
September 16, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28918463/apoptotic-mechanisms-after-repeated-noise-trauma-in-the-mouse-medial-geniculate-body-and-primary-auditory-cortex
#5
Felix Fröhlich, Arne Ernst, Ira Strübing, Dietmar Basta, Moritz Gröschel
A correlation between noise-induced apoptosis and cell loss has previously been shown after a single noise exposure in the cochlear nucleus, inferior colliculus, medial geniculate body (MGB) and primary auditory cortex (AI). However, repeated noise exposure is the most common situation in humans and a major risk factor for the induction of noise-induced hearing loss (NIHL). The present investigation measured cell death pathways using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) in the dorsal, medial and ventral MGB (dMGB, mMGB and vMGB) and six layers of the AI (AI-1 to AI-6) in mice (NMRI strain) after a second noise exposure (double-exposure group)...
September 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28918460/effects-of-cadmium-exposure-on-metal-accumulation-and-energy-metabolism-of-silver-carp-hypophthalmichthys-molitrix
#6
Deliang Li, Jie Pi, Jianping Wang, Pengfei Zhu, Deming Liu, Ting Zhang
Effects of cadmium (Cd) exposure on metal accumulation and energy metabolism of silver carp (Hypophthalmichthys molitrix) were studied during 14 days. The results showed that Cd accumulated in tissues of silver carp significantly with time and Cd concentration, as the order: liver > kidney > gill > muscle. The levels of muscle glycogen, triglyceride, and plasma triglyceride decreased significantly (p < 0.05). The levels of muscle protein, plasma glucose and lactate significantly increased during the first 8 days, and then all significantly decreased (p < 0...
September 16, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28918439/the-gulf-oil-spill-miscarriage-and-infertility-the-growh-study
#7
Emily W Harville, Arti Shankar, Leah Zilversmit, Pierre Buekens
PURPOSE: To examine whether reported exposure to the Gulf oil spill (2010) was related to reproductive reported miscarriage or infertility. METHODS: 1524 women aged 18-45 recruited through prenatal and Women, Infant, and Children (WIC) clinics, and community events were interviewed about their experience of the oil spill and reproductive history. 1434 women had information on outcomes of at least one pregnancy, and 633 on a pregnancy both before and after the spill...
September 16, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28918435/infant-avoidance-training-alters-cellular-activation-patterns-in-prefronto-limbic-circuits-during-adult-avoidance-learning-ii-cellular-imaging-of-neurons-expressing-the-activity-regulated-cytoskeleton-associated-protein-arc-arg3-1
#8
Nicole Gröger, Anja Mannewitz, Jörg Bock, Susann Becker, Katja Guttmann, Gerd Poeggel, Katharina Braun
Positive and negative feedback learning is essential to optimize behavioral performance. We used the two-way active avoidance (TWA) task as an experimental paradigm for negative feedback learning with the aim to test the hypothesis that neuronal ensembles activate the activity-regulated cytoskeletal (Arc/Arg3.1) protein during different phases of avoidance learning and during retrieval. A variety of studies in humans and other animals revealed that the ability of aversive feedback learning emerges postnatally...
September 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28918363/changes-in-zn-homeostasis-during-long-term-culture-of-primary-endothelial-cells-and-effects-of-zn-on-endothelial-cell-senescence
#9
Marco Malavolta, Laura Costarelli, Robertina Giacconi, Andrea Basso, Francesco Piacenza, Elisa Pierpaoli, Mauro Provinciali, Ogo A Ogo, Dianne Ford
Endothelial cell senescence and Zn nutritional status influence cardiovascular disease. The influence of Zn appears dichotomous, hence it is imperative to understand the relationship with cellular senescence to improve knowledge about the molecular and cellular basis of the disease. Here we aimed to determine: 1) the impact of chronic exposure to a moderately high dose of Zn on senescence of endothelial cells; 2) the changes in Zn homeostasis during the lifespan of primary cultured endothelial cells; and 3) the susceptibility of proliferating and senescent endothelial cells to cell death after short term exposure to increasing doses of Zn and of the Zn chelator TPEN...
September 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28918349/inhibition-of-anaerobic-digestion-processes-applications-of-molecular-tools
#10
REVIEW
Yamrot M Amha, Muhammad Zohaib Anwar, Andrew Brower, Carsten S Jacobsen, Lauren B Stadler, Tara M Webster, Adam L Smith
Inhibition of anaerobic digestion (AD) due to perturbation caused by substrate composition and/or operating conditions can significantly reduce performance. Such perturbations could be limited by elucidating microbial community response to inhibitors and devising strategies to increase community resilience. To this end, advanced molecular methods are increasingly being applied to study the AD microbiome, a diverse community of microbial populations with complex interactions. This literature review of AD inhibition studies indicates that inhibitory concentrations are highly variable, likely stemming from differences in community structure or activity profile and previous exposure to inhibitors...
September 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28918339/interference-of-dibutylphthalate-on-human-prostate-cell-viability
#11
Mariana Di Lorenzo, Maurizio Forte, Salvatore Valiante, Vincenza Laforgia, Maria De Falco
Dibutylphthalate (DBP) is an environmental pollutant widely used as plasticizer in a variety of industrial applications worldwide. This agent can be found in personal-care products, children's toy, pharmaceuticals, food products. Exposure to DBP can occur via ingestion and inhalation as well as intravenous or skin contact. DBP belongs to the family of endocrine disrupting chemicals (EDCs) and its effects on reproductive system were demonstrated both in vivo and in vitro. In the present study we evaluated the effects of DBP on human prostate adenocarcinoma epithelial cells (LNCaP) in order to highlight xenoestrogens influence on human prostate...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918336/total-and-cytosolic-concentrations-of-twenty-metals-metalloids-in-the-liver-of-brown-trout-salmo-trutta-linnaeus-1758-from-the-karstic-croatian-river-krka
#12
Zrinka Dragun, Vlatka Filipović Marijić, Nesrete Krasnići, Dušica Ivanković, Damir Valić, Jakov Žunić, Damir Kapetanović, Irena Vardić Smrzlić, Zuzana Redžović, Ivana Grgić, Marijana Erk
Total and cytosolic concentrations of twenty metals/metalloids in the liver of brown trout Salmo trutta (Linnaeus, 1758) were studied in the period from April 2015 to May 2016 at two sampling sites on Croatian river Krka, to establish if river water contamination with metals/metalloids downstream of Knin town has influenced metal bioaccumulation in S. trutta liver. Differences were observed between two sites, with higher concentrations of several elements (Ag, As, Ca, Co, Na, Se, Sr, V) found downstream of Knin town, whereas few others (Cd, Cs, Mo, Tl) were, unexpectedly, increased at the Krka River spring...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918277/lead-isotopic-fingerprint-in-human-scalp-hair-the-case-study-of-iglesias-mining-district-sardinia-italy
#13
D Varrica, G Dongarrà, M G Alaimo, F Monna, R Losno, E Sanna, G De Giudici, E Tamburo
The Sulcis-Iglesiente district (SW Sardinia, Italy) has been, until recently, one of the most important Italian polymetallic mining areas for the extraction of lead. Epidemiological studies conducted over several decades have indicated this site at high risk of environmental crisis with possible adverse effects on the public health. In the present paper we discuss Pb isotope signatures in human scalp hair and road dust collected from the Sulcis-Iglesiente area in order to trace the exposure of populations to potential Pb sources...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28918275/the-association-between-ambient-temperature-and-the-risk-of-preterm-birth-in-china
#14
Tongjun Guo, Yuanyuan Wang, Hongguang Zhang, Ya Zhang, Jun Zhao, Yan Wang, Xiaoxu Xie, Long Wang, Qian Zhang, Dujia Liu, Yuan He, Ying Yang, Jihong Xu, Zuoqi Peng, Xu Ma
BACKGROUND: With the gradual increase of global warming, the impact of extreme temperatures on health has become a focus of attention, however, its relationship with preterm birth remains unclear. OBJECTIVES: To investigate the association between exposure to extreme temperatures and preterm birth. METHODS: Temperature exposures and birth outcomes of 1,020,471 pregnant women from 132 cities in China were investigated. The pregnancy process was divided into different pregnancy periods...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28918274/distribution-comparison-and-risk-assessment-of-free-floating-and-particle-attached-bacterial-pathogens-in-urban-recreational-water-implications-for-water-quality-management
#15
Tingting Fang, Qijia Cui, Yong Huang, Peiyan Dong, Hui Wang, Wen-Tso Liu, Quanhui Ye
The risk of pathogen exposure in recreational water is a concern worldwide. Moreover, suspended particles, as ideal shelters for pathogens, in these waters also need attention. However, the risk caused by the pathogen-particle attachment is largely unknown. Accordingly, water samples in three recreational lakes in Beijing were collected and separated into free-floating (FL, 0.22-5μm) and particle-attached (PA, >5μm) fractions. Next-generation sequencing (NGS) was employed to determine the diversity of genera containing pathogens, and quantitative PCR (qPCR) was used to assess the presence of genes from Escherichia coli (uidA), Salmonella enterica (invA), Aeromonas spp...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28918267/compulsivity-in-opioid-dependence
#16
Serenella Tolomeo, Keith Matthews, J Douglas Steele, Alex Baldacchino
OBJECTIVE: This study aimed to investigate the relationship between compulsivity versus impulsivity and structural MRI abnormalities in opioid dependence. METHOD: We recruited 146 participants: i) patients with a history of opioid dependence due to chronic heroin use (n=24), ii) heroin users stabilised on methadone maintenance treatment (n=48), iii) abstinent participants with a history of opioid dependence due to heroin use (n=24) and iv) healthy controls (n=50)...
September 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28918233/the-role-of-callous-unemotional-traits-in-mediating-the-association-between-animal-abuse-exposure-and-behavior-problems-among-children-exposed-to-intimate-partner-violence
#17
Shelby Elaine McDonald, Julia Dmitrieva, Sunny Shin, Stephanie A Hitti, Sandra A Graham-Bermann, Frank R Ascione, James Herbert Williams
Children exposed to intimate partner violence are at increased risk for concomitant exposure to maltreatment of companion animals. There is emerging evidence that childhood exposure to maltreatment of companion animals is associated with psychopathology in childhood and adulthood. However, few studies have explored developmental factors that might help to explain pathways from animal maltreatment exposure to children's maladjustment. The present study addresses this gap in the literature by examining relations between children's exposure to animal maltreatment, callous/unemotional traits (i...
September 14, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28918202/implementation-of-a-risk-stratified-opioid-weaning-protocol-in-a-pediatric-intensive-care-unit
#18
L Nelson Sanchez-Pinto, Lara P Nelson, Phuong Lieu, Joyce Y Koh, John W Rodgers, Krichelle A Larson, Jennifer M Huson, Rambod Amirnovin
PURPOSE: Opioids are important in the care of critically ill children. However, their use is associated with complications including delirium, dependence, withdrawal, and bowel dysfunction. Our aim was to implement a risk-stratified opioid weaning protocol to reduce the duration of opioids without increasing the incidence of withdrawal. METHODS: A pre- and post-interventional prospective study was undertaken in a large children's hospital pediatric ICU where we implemented a risk-stratified opioid weaning protocol...
September 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28918194/cleaning-and-asthma-a-systematic-review-and-approach-for-effective-safety-assessment
#19
Melissa J Vincent, Ann Parker, Andrew Maier
Research indicates a correlative relationship between asthma and use of consumer cleaning products. We conduct a systematic review of epidemiological literature on persons who use or are exposed to cleaning products, both in occupational and domestic settings, and risk of asthma or asthma-like symptoms to improve understanding of the causal relationship between exposure and asthma. A scoring method for assessing study reliability is presented. Although research indicates an association between asthma and the use of cleaning products, no study robustly investigates exposure to cleaning products or ingredients along with asthma risk...
September 13, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28918109/precision-based-guidelines-for-sub-maximal-normalisation-task-selection-for-trunk-extensor-emg
#20
Jennie A Jackson, Svend Erik Mathiassen, Jack P Callaghan, Patrick G Dempsey
AIM: The object of this study was to quantify the contribution of sub-maximal normalisation to the overall variance of exposure parameters describing erector spinae (ES) activity, and to provide guidelines for task selection which minimize methodological variance. METHODS: ES EMG was measured from three locations (T9, L1 and L5 levels) on fifteen men performing a manual materials handling task in the laboratory on three separate days. Four repeats of each of eleven sub-maximal normalisation tasks (eight static, three dynamic) were collected, work data were normalised to each task and repeat, and exposure parameters calculated...
July 20, 2017: Journal of Electromyography and Kinesiology
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