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https://www.readbyqxmd.com/read/29040973/sulforaphane-and-epigallocatechin-gallate-restore-estrogen-receptor-expression-by-modulating-epigenetic-events-in-the-breast-cancer-cell-line-mda-mb-231-a-systematic-review-and-meta-analysis
#1
Vincenza Gianfredi, Samuele Vannini, Massimo Moretti, Milena Villarini, Nicola Luigi Bragazzi, Alberto Izzotti, Daniele Nucci
BACKGROUND/AIMS: Epigenetics refers to modifications in gene activity and expression without alteration at the DNA sequence. Environment and diet could influence gene expression. Diet modifications may be meaningful in preventing and treating chronic diseases, cancer included. Dietary bioactive compounds, such as polyphenols (e.g., curcumin, resveratrol, or epigallocatechin gallate [EGCG]) or isothiocyanate (e.g., sulforaphane [SFN]), can regulate histone acetylation. The aim of this systematic review and meta-analysis was to evaluate the effect of SFN and EGCG on breast cancer (BC) cells cultured in vitro...
October 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29040918/tumor-cryoablation-in-combination-with-natural-killer-cells-therapy-and-herceptin-in-patients-with-her2-overexpressing-recurrent-breast-cancer
#2
Shuzhen Liang, Lizhi Niu, Kecheng Xu, Xiaohua Wang, Yingqing Liang, Mingjie Zhang, Jibing Chen, Mao Lin
In this study, we investigated the clinical benefits of a combination of tumor cryoablation with natural killer (NK) cells therapy and Herceptin for human epidermal growth factor (HER) 2-overexpressing recurrent breast cancer. From May 2015 to May 2016, 48 patients who met the enrollment criteria were assigned to three groups (n=16): cryoablation group (group I), cryoablation-NK cells therapy group (group II) and cryoablation-NK cells therapy-Herceptin group (group III). Safety and short-term effects were evaluated...
October 13, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29040893/quality-of-online-information-on-breast-cancer-treatment-options
#3
Nadia Arif, Pietro Ghezzi
Offering breast cancer patients treatment choice has become a priority as the involvement of patients in the decision-making process is associated with improved physical and psychological outcomes. As the Internet is increasingly being used by patients as a source of medical information, it is important to evaluate the quality of information relating to breast cancer on the Internet. We analysed 200 websites returned by google.co.uk searching "breast cancer treatment options" in terms of their typology and treatment options described...
October 14, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29040886/role-of-n-6-methyladenosine-modification-in-cancer
#4
REVIEW
Xiaolan Deng, Rui Su, Xuesong Feng, Minjie Wei, Jianjun Chen
As the most abundant internal modification in eukaryotic messenger RNAs identified, N(6)-methyladenosine (m(6)A) has been shown recently to play essential roles in various normal bioprocesses. Evidence is emerging that m(6)A modification and its regulatory proteins also play critical roles in various cancers including leukemia, brain tumor, breast cancer and lung cancer, etc. For instance, FTO, the first m(6)A demethylase identified, has been reported recently to play an oncogenic role in leukemia and glioblastoma...
October 14, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29040808/independently-tuning-the-biochemical-and-mechanical-properties-of-3d-hyaluronan-based-hydrogels-with-oxime-and-diels-alder-chemistry-to-culture-breast-cancer-spheroids
#5
Alexander E G Baker, Roger Y Tam, Molly S Shoichet
In order to mimic native breast cancer cell growth in vitro as spheroids, a well-defined matrix that mimics the tumor microenvironment is required. Finding a biomimetic material for 3D cell culture, other than Matrigel, has challenged the field. Since hyaluronan is naturally abundant in the tumor microenvironment and can be chemically modified, we synthesized a hyalu-ronan hydrogel with independently tunable mechanical and chemical properties for 3D culture of breast cancer cells. By modifying HA with distinct bioorthogonal functional groups, its mechanical properties are controlled by chemical crosslinking via oxime liga-tion while its biochemical properties are controlled by grafting bioactive peptides via Diels-Alder chemistry...
October 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29040431/prevention-of-breast-cancer-induced-osteolytic-bone-resorption-by-benzyl-isothiocyanate
#6
Subrata K Pore, Eun-Ryeong Hahm, Joseph D Latoche, Carolyn J Anderson, Yongli Shuai, Shivendra V Singh
Osteolytic bone resorption is the primary cause of pain and suffering (e.g., pathological bone fracture) in women with metastatic breast cancer. The current standard of care for patients with bone metastasis for reducing the incidence of skeletal complications includes bisphosphonates and a humanized antibody (denosumab). However, a subset of patients on these therapies still develops new bone metastasis or experience adverse effects. Moreover, some bisphosphonates have poor oral bioavailability. Therefore, orally-bioavailable and non-toxic inhibitors of breast cancer-induced osteolytic bone resorption are still clinically desirable...
October 11, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29040217/shining-the-light-on-genitourinary-syndrome-of-menopause-in-survivors-of-breast-cancer
#7
Sheryl Kingsberg, Lisa Larkin
No abstract text is available yet for this article.
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29040039/breast-cancer-risk-associations-with-digital-mammographic-density-by-pixel-brightness-threshold-and-mammographic-system
#8
Tuong L Nguyen, Yoon-Ho Choi, Ye K Aung, Christopher F Evans, Nhut H Trinh, Shuai Li, Gillian S Dite, Myeong-Seong Kim, Patrick C Brennan, Mark A Jenkins, Joohon Sung, Yun-Mi Song, John L Hopper
Purpose To compare three mammographic density measures defined by different pixel intensity thresholds as predictors of breast cancer risk for two different digital mammographic systems. Materials and Methods The Korean Breast Cancer Study included 398 women with invasive breast cancer and 737 control participants matched for age at mammography (±1 year), examination date, mammographic system, and menopausal status. Mammographic density was measured by using the automated Laboratory for Individualized Breast Radiodensity Assessment (LIBRA) software and the semiautomated Cumulus software at the conventional threshold (Cumulus) and at increasingly higher thresholds (Altocumulus and Cirrocumulus, respectively)...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29040037/influence-of-risk-category-and-screening-round-on-the-performance-of-an-mr-imaging-and-mammography-screening-program-in-carriers-of-the-brca-mutation-and-other-women-at-increased-risk
#9
Suzan Vreemann, Albert Gubern-Mérida, Margrethe S Schlooz-Vries, Peter Bult, Carla H van Gils, Nicoline Hoogerbrugge, Nico Karssemeijer, Ritse M Mann
Purpose To evaluate the real-life performance of a breast cancer screening program for women with different categories of increased breast cancer risk with multiple follow-up rounds in an academic hospital with a large screening population. Materials and Methods Screening examinations (magnetic resonance [MR] imaging and mammography) for women at increased breast cancer risk (January 1, 2003, to January 1, 2014) were evaluated. Risk category, age, recall for workup of screening-detected abnormalities, biopsy, and histopathologic diagnosis were recorded...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29036941/breast-implant-associated-anaplastic-large-cell-lymphoma-in-a-transgender-woman
#10
Mintsje de Boer, Wouter B van der Sluis, Jan P de Boer, Lucy I H Overbeek, Flora E van Leeuwen, Hinne A Rakhorst, René R W J van der Hulst, Nathalie J Hijmering, Mark-Bram Bouman, Daphne de Jong
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare but serious complication in patients with breast implants, Patients are at risk of BIA-ALCL whether they receive breast implants for cosmetic reasons or for reconstructive purposes after surgery for breast cancer or prophylactic mastectomy. During the past decade, an increased number of reports have addressed BIA-ALCL. Herein, we describe BIA-ALCL in a transgender woman. The patient received breast implants as part of her gender transition and was diagnosed with BIA-ALCL 20 years later...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036915/stat3-but-not-hif-1%C3%AE-is-important-in-mediating-hypoxia-induced-chemoresistance-in-mda-mb-231-a-triple-negative-breast-cancer-cell-line
#11
Hoda Soleymani Abyaneh, Nidhi Gupta, Aneta Radziwon-Balicka, Paul Jurasz, John Seubert, Raymond Lai, Afsaneh Lavasanifar
Hypoxia-induced chemoresistance (HICR) is a well-recognized phenomenon, and in many experimental models, hypoxia inducible factor-1α (HIF-1α) is believed to be a key player. We aimed to better understand the mechanism underlying HICR in a triple negative breast cancer cell line, MDA-MB-231, with a focus on the role of HIF-1α. In this context, the effect of hypoxia on the sensitivity of MDA-MB-231 cells to cisplatin and their stem-like features was evaluated and the role of HIF-1α in both phenomena was assessed...
October 14, 2017: Cancers
https://www.readbyqxmd.com/read/29036807/obtaining-and-characterization-of-monoclonal-antibodies-against-recombinant-extracellular-domain-of-human-epidermal-growth-factor-receptor-2
#12
Sarina Nurgul, Abeldenov Sailau, Turgimbayeva Aigerim, Zhylkibayev Assylbek, Ramankulov Erlan, Khassenov Bekbolat, Eskendirova Saule
Human epidermal growth factor receptor 2 (HER2) is an important biomarker for detection and treatment of different types of cancers such as breast, ovarian, stomach cancer. In this study, we developed a monoclonal antibody against the extracellular domain (ECD) of HER2 biomarker of breast cancer. For this purpose, the ECD-HER2 gene was amplified and cloned into an expression vector. Gene was generated in Escherichia coli BL21 (DE3) strain for expression of recombinant protein. The expressed protein was separated by SDS-PAGE and detected by anti-his monoclonal antibody in immunoblotting...
September 8, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29036789/protein-kinase-c-%C3%AE-dependent-regulation-of-ubiquitin-proteasome-system-function-in-breast-cancer
#13
Si Sun, Qi Wu, Junlong Song, Shengrong Sun
Besides the crucial role of hyperinsulinemia in the development of breast cancer with Type 2 diabetes mellitus (T2DM), it has been shown that hyperglycemia could contribute to promote cancer progression. A remarkable association within hyperglycemia, PKCδ and Ubiquitin-proteasome system (UPS) has been reported, suggesting that PKCδ may mediate high glucose-induced UPS activation in breast cancer cells. Although the independent effects of PKCδ or UPS on breast cancer and T2DM are increasingly supported by experimental evidence, the complex interactional link between PKCδ and UPS is still unclear...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29036752/breast-cancer-screening-updated-recommendations-of-the-brazilian-college-of-radiology-and-diagnostic-imaging-brazilian-breast-disease-society-and-brazilian-federation-of-gynecological-and-obstetrical-associations
#14
Linei Augusta Brolini Dellê Urban, Luciano Fernandes Chala, Selma di Pace Bauab, Marcela Brisighelli Schaefer, Radiá Pereira Dos Santos, Norma Medicis de Albuquerque Maranhão, Ana Lucia Kefalas, José Michel Kalaf, Carlos Alberto Pecci Ferreira, Ellyete de Oliveira Canella, João Emílio Peixoto, Heverton Leal Ernesto de Amorim, Helio Sebastião Amâncio de Camargo Junior
No abstract text is available yet for this article.
October 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29036489/training-community-health-workers-to-promote-breast-cancer-screening-in-brazil
#15
Lorna Bittencourt, Isabel C Scarinci
Although it has been show that early detection through mammograms is the most effective way to reduce breast cancer mortality, breast cancer is the leading cause of cancer deaths among women worldwide with survival rates being even lower in low- and middle-income countries as compared to high-income countries. Despite the availability of breast cancer screening programs in Brazil through the public health system, some women do not participate in these programs due to structural and/or inter/intrapersonal barriers...
September 26, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29036414/monthly-variation-in-mammographic-screening-attendance-in-norway
#16
Kaitlyn M Tsuruda, Sameer Bhargava, Gunhild Mangerud, Silje Sagstad, Solveig S H Hofvind
Breast Cancer Awareness Month (BCAM) increases screening attendance in the USA. However, this effect has not been investigated in Europe, where organized screening is widespread. We examined monthly attendance within the Norwegian Breast Cancer Screening Programme, 2005-15. Relative to October, the odds of attending screening in January, February, March, August, September or December were slightly decreased (ORadj 0.93-0.98, P ≤ 0.003 for all). BCAM may marginally increase attendance in October but seasonal factors such as weather may also explain this observed variation...
October 3, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29036268/breast-cancer-estrogen-receptor-by-biological-generation-us-black-white-women-born-1915-1979
#17
Nancy Krieger, Jaquelyn L Jahn, Pamela D Waterman, Jarvis T Chen
Evidence suggests contemporary population distributions of breast cancer estrogen receptor (ER) status may be shaped by earlier major societal events, such as the 1965 abolition of Jim Crow (legal racial discrimination in the US) and the Great Famine in China (1959-1961). We accordingly analyzed changes in ER status in relation to Jim Crow birth place among the 46,417 black and 339,830 white US-born non-Hispanic women in the 13 SEER Registry Group who were born between 1915 and 1979 and diagnosed (age 25-84, inclusive) between 1992-2012...
September 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036190/clusternomics-integrative-context-dependent-clustering-for-heterogeneous-datasets
#18
Evelina Gabasova, John Reid, Lorenz Wernisch
Integrative clustering is used to identify groups of samples by jointly analysing multiple datasets describing the same set of biological samples, such as gene expression, copy number, methylation etc. Most existing algorithms for integrative clustering assume that there is a shared consistent set of clusters across all datasets, and most of the data samples follow this structure. However in practice, the structure across heterogeneous datasets can be more varied, with clusters being joined in some datasets and separated in others...
October 16, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29035997/stewart-treves-syndrome-on-the-lower-extremity-associated-to-idiopathic-chronic-lymphedema-visualized-on-fdg-pet-ct
#19
Jane Maestri Brittain, Tine Nymark, Malene Grubbe Hildebrandt, Dorrit Hovgaard, Kim Francis Andersen
Angiosarcomas are highly malignant and rare tumors of vascular or lymphatic endothelial cell origin with a poor prognosis. Lymphangiosarcoma associated with chronic lymphedema is known as Stewart-Treves syndrome. Stewart-Treves syndrome is primarily described in patients with lymphedema of an upper extremity occurring after breast cancer surgery including radical axillary lymph node dissection and subsequent radiotherapy. It is rarely described in the presence of idiopathic chronic lymphedema of the lower extremities...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29035873/multi-task-transfer-learning-deep-convolutional-neural-network-application-to-computer-aided-diagnosis-of-breast-cancer-on-mammograms
#20
Ravi K Samala, Heang-Ping Chan, Lubomir M Hadjiiski, Mark A Helvie, Kenny Cha, Caleb Richter
Transfer learning in deep convolutional neural networks (DCNNs) is an important step in its application to medical imaging tasks. We propose a multi-task transfer learning DCNN with the aims of translating the 'knowledge' learned from non-medical images to medical diagnostic tasks through supervised training and increasing the generalization capabilities of DCNNs by simultaneously learning auxiliary tasks. We studied this approach in an important application: classification of malignant and benign breast masses...
October 16, 2017: Physics in Medicine and Biology
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