B H Schott, A Assmann, P Schmierer, J Soch, S Erk, M Garbusow, S Mohnke, L Pöhland, N Romanczuk-Seiferth, A Barman, T Wüstenberg, L Haddad, O Grimm, S Witt, S Richter, M Klein, H Schütze, T W Mühleisen, S Cichon, M Rietschel, M M Noethen, H Tost, E D Gundelfinger, E Düzel, A Heinz, A Meyer-Lindenberg, C I Seidenbecher, H Walter
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. Previous neuroimaging studies of depression-related endophenotypes have highlighted the role of the subgenual cingulate cortex (CG25) in negative mood and depressive psychopathology. Here, we aimed to assess how recently associated PCLO and CACNA1C depression risk alleles jointly affect memory-related CG25 activity as an intermediate phenotype in clinically healthy humans...
March 18, 2014: Translational Psychiatry