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Calbindin-d28k

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https://www.readbyqxmd.com/read/29151114/non-canonical-heterogeneous-cellular-distribution-and-co-localization-of-camkii%C3%AE-and-camkii%C3%AE-in-the-spinal-superficial-dorsal-horn
#1
Max Larsson
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a key enzyme in long-term plasticity in many neurons, including in the nociceptive circuitry of the spinal dorsal horn. However, although the role of CaMKII heterooligomers in neuronal plasticity is isoform-dependent, the distribution and co-localization of CaMKII isoforms in the dorsal horn have not been comprehensively investigated. Here, quantitative immunofluorescence analysis was used to examine the distribution of the two major neuronal CaMKII isoforms, α and β, in laminae I-III of the rat dorsal horn, with reference to inhibitory interneurons and neuronal populations defined by expression of parvalbumin, calretinin, and calbindin D28k...
November 18, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29130968/immunohistochemical-localization-of-calbindin-d28k-parvalbumin-and-calretinin-in-the-superior-olivary-complex-of-circling-mice
#2
Jin-Koo Lee, Dhiraj Maskey, Myeung Ju Kim
The circling mouse serves as a hearing loss model. It has spontaneous tmie gene mutations that cause hair cell and cochlear degeneration. However, little is known about the role of the tmie gene in superior olivary complex (SOC) regions, in which sound information from the two ears is integrated and primarily relayed to the nuclei of the lateral lemniscus and inferior colliculus. Several studies have reported that abnormal calcium (Ca2+) homeostasis is associated with the pathology of hearing loss. This study investigated the distribution of Ca2+-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the SOC of the circling mouse on postnatal day 16...
November 4, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29121589/pharmacological-targeting-of-gsk-3-and-nrf2-provides-neuroprotection-in-a-preclinical-model-of-tauopathy
#3
Antonio Cuadrado, Sebastian Kügler, Isabel Lastres-Becker
Tauopathies are a group of neurodegenerative disorders where TAU protein is presented as aggregates or is abnormally phosphorylated, leading to alterations of axonal transport, neuronal death and neuroinflammation. Currently, there is no treatment to slow progression of these diseases. Here, we have investigated whether dimethyl fumarate (DMF), an inducer of the transcription factor NRF2, could mitigate tauopathy in a mouse model. The signaling pathways modulated by DMF were also studied in mouse embryonic fibroblast (MEFs) from wild type or KEAP1-deficient mice...
November 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/29090497/characterization-of-calbindin-d28k-expressing-interneurons-in-the-ventral-horn-of-the-mouse-spinal-cord
#4
Taylor L Floyd, Yiyun Dai, David R Ladle
BACKGROUND: Expression of the calcium binding protein, calbindin (CB), is well established as a hallmark of Renshaw cells, a class of interneurons found in spatially restricted areas in the ventral spinal cord that directly modulate motor neuron activity. CB expression, however, is not restricted only to Renshaw cells in the ventral horn, and within this population other interneuron subtypes may be identifiable on the basis of cell position and the potential for coexpression of other calcium binding proteins...
November 1, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29077932/effects-of-dietary-mn-methionine-supplementation-on-the-egg-quality-of-laying-hens
#5
L L Li, N N Zhang, Y J Gong, M Y Zhou, H Q Zhan, X T Zou
This study was conducted to investigate the effects of dietary manganese-methionine (Mn-Met) supplementation on the egg quality of laying hens. A total of 480 Jinghong-1 strain layers aged 53 wk were divided into 5 groups with 6 replicates of 16 layers. Birds in the control group were fed a diet supplemented with 60 mg Mn/kg in the form of MnSO4; the birds in other 4 experimental groups were fed a diet supplemented with 20, 40, 60, and 80 mg Mn/kg as Mn-Met, respectively. Dietary Mn-Met treatments significantly affected (P < 0...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29051111/perspectives-on-using-a-multiplex-human-kidney-safety-biomarker-panel-to-detect-cisplatin-induced-tubular-toxicity-in-male-and-female-cynomolgus-monkeys
#6
Yafei Chen, J Dale Thurman, Lewis B Kinter, Russell Bialecki, J Eric McDuffie
Multiplex biomarker panel assays would enable early de-risking of discovery compound related kidney safety liabilities. The objective of this study was to evaluate the usefulness of the Myriad RBM Human KidneyMAP (Multi-Analyte Profile)® v.1.0 panel to detect experimental nephrotoxicity in Cynomolgus monkeys following a single intravenous administration of cisplatin (2.5mg/kg). Urine samples were collected at baseline on day -2; at approximately 4hr post-dose on day 1; and on days 4, 9, 15 and/or 20. Blood samples were collected at predose on day -2; at 4hr post-dose on day 1; and on days 2, 5, 10 and/or 21...
October 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29043988/effects-of-estrogen-on-learning-memory-and-expression-of-calbindin-d28k-in-hippocampus-in-vascular-dementia-rats
#7
Jing Li, Lei Zhang, Jiao-Jiao Li, - Xian-Qu, Lin Chen, Dong-Ying Li, Chun-Ying Li
Vascular dementia (VD) models were made first by repeating cerebral ischemia-reperfusion and followed by treating with estrogen. Learning-memory ability was measured by Morris water maze. Concentration of Ca(2+) in hippocampus was determined by Fura-2/AM fluorescence probe and the expression of Calbindin-D28K (CB) in hippocampal CA1 was tested by immunohistochemistry. Learning-memory ability was improved in E group rats; Concentration of Ca(2+) in hippocampus was decreased in E group rats. The expression of CB was less in E group rats...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29043102/the-distribution-of-calbindin-d28k-parvalbumin-and-calretinin-immunoreactivity-in-the-inferior-colliculus-of-circling-mouse
#8
Jin-Koo Lee, Myeung Ju Kim
The circling mice with tmie gene mutation are known as an animal deafness model, which showed hyperactive circling movement. Recently, the reinvestigation of circling mouse was performed to check the inner ear pathology as a main lesion of early hearing loss. In this trial, the inner ear organs were not so damaged to cause the hearing deficit of circling (cir/cir) mouse at 18 postnatal day (P18) though auditory brainstem response data indicated hearing loss of cir/cir mice at P18. Thus, another mechanism may be correlated with the early hearing loss of cir/cir mice at P18...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29035369/epigenetic-suppression-of-hippocampal-calbindin-d28k-by-%C3%AE-fosb-drives-seizure-related-cognitive-deficits
#9
Jason C You, Kavitha Muralidharan, Jin W Park, Iraklis Petrof, Mark S Pyfer, Brian F Corbett, John J LaFrancois, Yi Zheng, Xiaohong Zhang, Carrie A Mohila, Daniel Yoshor, Robert A Rissman, Eric J Nestler, Helen E Scharfman, Jeannie Chin
The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognition, but its expression is markedly decreased in various neurological disorders associated with epileptiform activity and seizures. In Alzheimer's disease (AD) and epilepsy, both of which are accompanied by recurrent seizures, the severity of cognitive deficits reflects the degree of calbindin reduction in the hippocampal dentate gyrus (DG). However, despite the importance of calbindin in both neuronal physiology and pathology, the regulatory mechanisms that control its expression in the hippocampus are poorly understood...
November 2017: Nature Medicine
https://www.readbyqxmd.com/read/28965932/sexual-behavior-associated-c-fos-induction-in-the-sagittalis-nucleus-of-the-hypothalamus-in-male-rat
#10
Ken Ichi Matsuda, Kei Uchiyama, Hiroko Mori, Sho Maejima, Shohei Yamaguchi, Masaki Tanaka, Shinji Tsukahara
The sagittalis nucleus of the hypothalamus (SGN) is a small nucleus located in the interstitial area between the arcuate and ventromedial nuclei of the hypothalamus in rats. The SGN exhibits male-biased sexual dimorphism and expresses estrogen receptor α and calbindin-D28K. This suggests a contribution of the SGN to sexually differentiated brain function, but its functional role is unknown. In this study, neuronal activation in the SGN during sexual behavior in male rats was examined by c-Fos immunohistochemistry...
November 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28954211/calcium-binding-proteins-expression-in-the-septum-and-cingulate-cortex-of-the-adult-guinea-pig
#11
Beata Hermanowicz-Sobieraj, Krystyna Bogus-Nowakowska, Anna Robak
For the first time this study demonstrates the distribution pattern and expression of three neuroanatomical markers: calbindin D28k (CB), calretinin (CR) and parvalbumin (PV) in topographically connected brain regions - the septum (SE) and the cingulate cortex (CC). The co-existence among calcium-binding proteins (CaBPs) was also examined. The study was conducted on the adult guinea pig with the use of immunohistochemical and molecular biological techniques. Among the studied CaBPs, which occurred in both examined brain regions at transcript and protein levels, CB was the most expressed in the SE, while CR in the CC...
September 24, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28944879/immunoreactivities-of-calbindin%C3%A2-d28k-calretinin-and-parvalbumin-in-the-somatosensory-cortex-of-rodents-during-normal-aging
#12
Ji Hyeon Ahn, Seongkweon Hong, Joon Ha Park, In Hye Kim, Jeong Hwi Cho, Tae-Kyeong Lee, Jae-Chul Lee, Bai Hui Chen, Bich-Na Shin, Eun Joo Bae, Yong Hwan Jeon, Young-Myeong Kim, Moo-Ho Won, Soo Young Choi
Calbindin‑D28k (CB), calretinin (CR) and parvalbumin (PV), which regulate cytosolic free Ca2+ concentrations in neurons, are chemically expressed in γ‑aminobutyric acid (GABA)ergic neurons that regulate the degree of glutamatergic excitation and output of projection neurons. The present study investigated age‑associated differences in CB, CR and PV immunoreactivities in the somatosensory cortex in three species (mice, rats and gerbils) of young (1 month), adult (6 months) and aged (24 months) rodents, using immunohistochemistry and western blotting...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28861331/alteration-of-interneuron-immunoreactivity-and-autophagic-activity-in-rat-hippocampus-after-single-high-dose-whole-brain-irradiation
#13
Yi-Bing Ouyang, Shoucheng Ning, John R Adler, Bruce Maciver, Susan J Knox, Rona Giffard
The effects of high dose gamma radiation on brain tissue are poorly understood, with both limited and major changes reported. The present study compared the effects of gamma irradiation on the expression of interneuron markers within the hippocampal cornu ammonis 1 (CA1) region with expression in control matched rats. This area was chosen for study because of its well-characterized circuitry. Male Sprague-Dawley rats were exposed to 60 Gy of whole brain gamma radiation and after 24 or 48 hours, the brains were removed, fixed and sectioned to quantitate expression of parvalbumin (PV), calbindin-D28K (CB), reelin, neuropeptide-Y (NPY), and somatostatin...
June 30, 2017: Curēus
https://www.readbyqxmd.com/read/28840477/a-working-module-for-the-neurovascular-unit-in-the-sexually-dimorphic-nucleus-of-the-preoptic-area
#14
Zhen He, Li Cui, Sherry A Ferguson, Merle G Paule
The neurovascular unit (NVU) can be conceptualized as a functional entity consisting of neurons, astrocytes, pericytes, and endothelial and smooth muscle cells that operate in concert to affect blood flow to a very circumscribed area. Although we are currently in a "golden era" of bioengineering, there are, as yet, no living NVUs-on-a-chip modules available and the development of a neural chip that would mimic NVUs is a seemingly lofty goal. The sexually dimorphic nucleus of the preoptic area (SDN-POA) is a tiny brain structure (between 0...
August 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28761424/neuroprotective-effects-of-ischemic-preconditioning-on-hippocampal-ca1-pyramidal-neurons-through-maintaining-calbindin-d28k-immunoreactivity-following-subsequent-transient-cerebral-ischemia
#15
In Hye Kim, Yong Hwan Jeon, Tae-Kyeong Lee, Jeong Hwi Cho, Jae-Chul Lee, Joon Ha Park, Ji Hyeon Ahn, Bich-Na Shin, Yang Hee Kim, Seongkweon Hong, Bing Chun Yan, Moo-Ho Won, Yun Lyul Lee
Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult. In this study, we investigated the neuroprotective effects of ischemic preconditioning (2-minute transient cerebral ischemia) on calbindin D28k immunoreactivity in the gerbil hippocampal CA1 area following a subsequent fatal transient ischemic insult (5-minute transient cerebral ischemia). A large number of pyramidal neurons in the hippocampal CA1 area died 4 days after 5-minute transient cerebral ischemia...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28732794/glutamine-protects-intestinal-calcium-absorption-against-oxidative-stress-and-apoptosis
#16
Luciana Moine, Gabriela Díaz de Barboza, Adriana Pérez, Mercedes Benedetto, Nori Tolosa de Talamoni
The aim of this study was to investigate whether glutamine (GLN) could block the inhibition of the intestinal Ca(2+) absorption caused by menadione (MEN), and elucidate the underlying mechanisms. To do this, one-month old chicks were divided in four groups: 1) controls, 2) MEN treated, 3) GLN treated and 4) GLN treated before or after MEN treatment. Intestinal Ca(2+) absorption as well as protein expression of molecules involved in the transcellular Ca(2+) pathway were determined. Glutathione (GSH) and superoxide anion and activity of enzymes of the antioxidant system were evaluated...
July 19, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28681399/distribution-of-calretinin-immunoreactivity-in-the-lateral-nucleus-of-the-bottlenose-dolphin-tursiops-truncatus-amygdala
#17
A M Rambaldi, B Cozzi, A Grandis, M Canova, M Mazzoni, C Bombardi
The amgdaloid complex consists of different nuclei, each with unique cytoarchitectonic, chemoarchitectonic and connectional characteristics. Most of the inputs coming from cortical and subcortical areas enter the amygdala via the lateral nucleus, which makes it the main receiving structure of the complex. The activity of its neurons is coordinated and modulated by different inhibitory, GABAergic-interneurons, which can be classified for their expression of various calcium-binding proteins, as well as by morphological characteristics...
July 6, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28539338/expression-of-transcellular-and-paracellular-calcium-and-magnesium-transport-proteins-in-renal-and-intestinal-epithelia-during-lactation
#18
Megan R Beggs, Ida Appel, Per Svenningsen, Karsten Skjødt, R Todd Alexander, Henrik Dimke
Significant alterations in maternal calcium (Ca(2+)) and magnesium (Mg(2+)) balance occur during lactation. Ca(2+) is the primary divalent cation mobilized into breast milk by demineralization of the skeleton and alterations in intestinal and renal Ca(2+) transport. Mg(2+) is also concentrated in breast milk, but the underlying mechanisms are not well understood. To determine the molecular alterations in Ca(2+) and Mg(2+) transport in the intestine and kidney during lactation, three groups of female mice consisting of either nonpregnant controls, lactating mice, or mice undergoing involution were examined...
September 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28398586/neonatal-inhibition-of-dna-methylation-alters-cell-phenotype-in-sexually-dimorphic-regions-of-the-mouse-brain
#19
Morgan Mosley, Jill Weathington, Laura R Cortes, Emily Bruggeman, Alexandra Castillo-Ruiz, Bingzhong Xue, Nancy G Forger
Many of the best-studied neural sex differences relate to differences in cell number and are due to the hormonal control of developmental cell death. However, several prominent neural sex differences persist even if cell death is eliminated. We hypothesized that these may reflect cell phenotype "decisions" that depend on epigenetic mechanisms, such as DNA methylation. To test this, we treated newborn mice with the DNA methyltransferase (DNMT) inhibitor zebularine, or vehicle, and examined two sexually dimorphic markers at weaning...
June 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28394432/immunofluorescence-reveals-unusual-patterns-of-labelling-for-connexin43-localized-to-calbindin-d28k-positive-interstitial-cells-in-the-pineal-gland
#20
D D Tsao, S G Wang, B D Lynn, J I Nagy
Gap junctions between cells in the pineal gland have been described ultrastructurally, but their connexin constituents have not been fully characterized. We used immunofluorescence in combination with markers of pineal cells to document the cellular localization of connexin43 (Cx43). Immunofluorescence labelling of Cx43 with several different antibodies was widely distributed throughout the pineal, whereas another connexin examined, connexin26, was not found in pineal but only in surrounding leptomeninges. Labelling apparently associated with plasma membranes was visualized either as fine Cx43-puncta (1-2 μm) or as unusually large pools of Cx43 ranging up to 4-7 μm in diameter or length...
April 10, 2017: European Journal of Neuroscience
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