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CACNA1C memory recall

Stephanie J Temme, Ryan Z Bell, Grace L Fisher, Geoffrey G Murphy
L-type voltage-gated calcium channels (LVGCCs) have been implicated in various forms of learning, memory, and synaptic plasticity. Within the hippocampus, the LVGCC subtype, CaV 1.2 is prominently expressed throughout the dentate gyrus. Despite the apparent high levels of CaV 1.2 expression in the dentate gyrus, the role of CaV 1.2 in hippocampal- and dentate gyrus-associated forms of learning remain unknown. To address this question, we examined alternate forms of hippocampal-dependent associative and spatial memory in mice lacking the mouse ortholog of CACNA1C ( Cacna1c ), which encodes CaV 1...
November 2016: ENeuro
Gen Shinozaki, James B Potash
The last several years have been breakthrough ones in bipolar disorder (BPD) genetics, as the field has identified robust risk variants for the first time. Leading the way have been genome-wide association studies (GWAS) that have assessed common genetic markers across very large groups of patients and controls. These have resulted in findings in genes including ANK3, CACNA1C, SYNE1, ODZ4, and TRANK1. Additional studies have begun to examine the biology of these genes and how risk variants influence aspects of brain and behavior that underlie BPD...
November 2014: Current Psychiatry Reports
Susanne Erk, Andreas Meyer-Lindenberg, David E J Linden, Thomas Lancaster, Sebastian Mohnke, Oliver Grimm, Franziska Degenhardt, Peter Holmans, Andrew Pocklington, Phöbe Schmierer, Leila Haddad, Thomas W Mühleisen, Manuel Mattheisen, Stephanie H Witt, Nina Romanczuk-Seiferth, Heike Tost, Björn H Schott, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Andreas Heinz, Henrik Walter
Variation in the CACNA1C gene has consistently been associated with psychosis in genome wide association studies. We have previously shown in a sample of n=110 healthy subjects that carriers of the CACNA1C rs1006737 risk variant exhibit hippocampal and perigenual anterior cingulate dysfunction (pgACC) during episodic memory recall. Here, we aimed to replicate our results, by testing for the effects of the rs1006737 risk variant in a new large cohort of healthy controls. We furthermore sought to refine these results by identifying the impact of a CACNA1C specific, gene-wide risk score in the absence of clinical pathology...
July 1, 2014: NeuroImage
Susanne Erk, Andreas Meyer-Lindenberg, Phöbe Schmierer, Sebastian Mohnke, Oliver Grimm, Maria Garbusow, Leila Haddad, Lydia Poehland, Thomas W Mühleisen, Stephanie H Witt, Heike Tost, Peter Kirsch, Nina Romanczuk-Seiferth, Björn H Schott, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Andreas Heinz, Henrik Walter
BACKGROUND: Variation in CACNA1C has consistently been associated with psychiatric disease in genome-wide association studies. We have previously shown that healthy carriers of the CACNA1C rs1006737 risk variant exhibit hippocampal and perigenual anterior cingulate (pgACC) dysfunction during episodic memory recall. To test whether this brain systems-level abnormality is a potential intermediate phenotype for psychiatric disorder, we studied unaffected relatives of patients with bipolar disorder, major depression, and schizophrenia...
September 15, 2014: Biological Psychiatry
Axel Krug, Stephanie H Witt, Heidelore Backes, Bruno Dietsche, Vanessa Nieratschker, N Jon Shah, Markus M Nöthen, Marcella Rietschel, Tilo Kircher
The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression. It is involved in learning, memory and brain plasticity. Genetic studies using functional magnetic resonance imaging (fMRI) reported evidence of association with the CACNA1C single nucleotide polymorphism rs1006737 with functional correlates of episodic memory encoding and retrieval, especially activations in the hippocampus...
March 2014: European Archives of Psychiatry and Clinical Neuroscience
Susanne Erk, Andreas Meyer-Lindenberg, Knut Schnell, Carola Opitz von Boberfeld, Christine Esslinger, Peter Kirsch, Oliver Grimm, Claudia Arnold, Leila Haddad, Stephanie H Witt, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Henrik Walter
CONTEXT: The neural abnormalities underlying genetic risk for bipolar disorder, a severe, common, and highly heritable psychiatric condition, are largely unknown. An opportunity to define these mechanisms is provided by the recent discovery, through genome-wide association, of a single-nucleotide polymorphism (rs1006737) strongly associated with bipolar disorder within the CACNA1C gene, encoding the alpha subunit of the L-type voltage-dependent calcium channel Ca(v)1.2. OBJECTIVE: To determine whether the genetic risk associated with rs1006737 is mediated through hippocampal function...
August 2010: Archives of General Psychiatry
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