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https://www.readbyqxmd.com/read/27845344/multidimensional-heritability-analysis-of-neuroanatomical-shape
#1
Tian Ge, Martin Reuter, Anderson M Winkler, Avram J Holmes, Phil H Lee, Lee S Tirrell, Joshua L Roffman, Randy L Buckner, Jordan W Smoller, Mert R Sabuncu
In the dawning era of large-scale biomedical data, multidimensional phenotype vectors will play an increasing role in examining the genetic underpinnings of brain features, behaviour and disease. For example, shape measurements derived from brain MRI scans are multidimensional geometric descriptions of brain structure and provide an alternate class of phenotypes that remains largely unexplored in genetic studies. Here we extend the concept of heritability to multidimensional traits, and present the first comprehensive analysis of the heritability of neuroanatomical shape measurements across an ensemble of brain structures based on genome-wide SNP and MRI data from 1,320 unrelated, young and healthy individuals...
November 15, 2016: Nature Communications
https://www.readbyqxmd.com/read/27694991/novel-genetic-loci-underlying-human-intracranial-volume-identified-through-genome-wide-association
#2
Hieab H H Adams, Derrek P Hibar, Vincent Chouraki, Jason L Stein, Paul A Nyquist, Miguel E Rentería, Stella Trompet, Alejandro Arias-Vasquez, Sudha Seshadri, Sylvane Desrivières, Ashley H Beecham, Neda Jahanshad, Katharina Wittfeld, Sven J Van der Lee, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S Aribisala, Nicola J Armstrong, Lavinia Athanasiu, Tomas Axelsson, Alexa Beiser, Manon Bernard, Joshua C Bis, Laura M E Blanken, Susan H Blanton, Marc M Bohlken, Marco P Boks, Janita Bralten, Adam M Brickman, Owen Carmichael, M Mallar Chakravarty, Ganesh Chauhan, Qiang Chen, Christopher R K Ching, Gabriel Cuellar-Partida, Anouk Den Braber, Nhat Trung Doan, Stefan Ehrlich, Irina Filippi, Tian Ge, Sudheer Giddaluru, Aaron L Goldman, Rebecca F Gottesman, Corina U Greven, Oliver Grimm, Michael E Griswold, Tulio Guadalupe, Johanna Hass, Unn K Haukvik, Saima Hilal, Edith Hofer, David Hoehn, Avram J Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Dalia Kasperaviciute, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H Lee, Jiemin Liao, David C M Liewald, Lorna M Lopez, Michelle Luciano, Christine Macare, Andre Marquand, Mar Matarin, Karen A Mather, Manuel Mattheisen, Bernard Mazoyer, David R McKay, Rebekah McWhirter, Yuri Milaneschi, Nazanin Mirza-Schreiber, Ryan L Muetzel, Susana Muñoz Maniega, Kwangsik Nho, Allison C Nugent, Loes M Olde Loohuis, Jaap Oosterlaan, Martina Papmeyer, Irene Pappa, Lukas Pirpamer, Sara Pudas, Benno Pütz, Kumar B Rajan, Adaikalavan Ramasamy, Jennifer S Richards, Shannon L Risacher, Roberto Roiz-Santiañez, Nanda Rommelse, Emma J Rose, Natalie A Royle, Tatjana Rundek, Philipp G Sämann, Claudia L Satizabal, Lianne Schmaal, Andrew J Schork, Li Shen, Jean Shin, Elena Shumskaya, Albert V Smith, Emma Sprooten, Lachlan T Strike, Alexander Teumer, Russell Thomson, Diana Tordesillas-Gutierrez, Roberto Toro, Daniah Trabzuni, Dhananjay Vaidya, Jeroen Van der Grond, Dennis Van der Meer, Marjolein M J Van Donkelaar, Kristel R Van Eijk, Theo G M Van Erp, Daan Van Rooij, Esther Walton, Lars T Westlye, Christopher D Whelan, Beverly G Windham, Anderson M Winkler, Girma Woldehawariat, Christiane Wolf, Thomas Wolfers, Bing Xu, Lisa R Yanek, Jingyun Yang, Alex Zijdenbos, Marcel P Zwiers, Ingrid Agartz, Neelum T Aggarwal, Laura Almasy, David Ames, Philippe Amouyel, Ole A Andreassen, Sampath Arepalli, Amelia A Assareh, Sandra Barral, Mark E Bastin, Diane M Becker, James T Becker, David A Bennett, John Blangero, Hans van Bokhoven, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Han G Brunner, Randy L Buckner, Jan K Buitelaar, Kazima B Bulayeva, Wiepke Cahn, Vince D Calhoun, Dara M Cannon, Gianpiero L Cavalleri, Christopher Chen, Ching-Yu Cheng, Sven Cichon, Mark R Cookson, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E Curran, Michael Czisch, Anders M Dale, Gareth E Davies, Eco J C De Geus, Philip L De Jager, Greig I de Zubicaray, Norman Delanty, Chantal Depondt, Anita L DeStefano, Allissa Dillman, Srdjan Djurovic, Gary Donohoe, Wayne C Drevets, Ravi Duggirala, Thomas D Dyer, Susanne Erk, Thomas Espeseth, Denis A Evans, Iryna O Fedko, Guillén Fernández, Luigi Ferrucci, Simon E Fisher, Debra A Fleischman, Ian Ford, Tatiana M Foroud, Peter T Fox, Clyde Francks, Masaki Fukunaga, J Raphael Gibbs, David C Glahn, Randy L Gollub, Harald H H Göring, Hans J Grabe, Robert C Green, Oliver Gruber, Vilmundur Gudnason, Sebastian Guelfi, Narelle K Hansell, John Hardy, Catharina A Hartman, Ryota Hashimoto, Katrin Hegenscheid, Andreas Heinz, Stephanie Le Hellard, Dena G Hernandez, Dirk J Heslenfeld, Beng-Choon Ho, Pieter J Hoekstra, Wolfgang Hoffmann, Albert Hofman, Florian Holsboer, Georg Homuth, Norbert Hosten, Jouke-Jan Hottenga, Hilleke E Hulshoff Pol, Masashi Ikeda, M Kamran Ikram, Clifford R Jack, Mark Jenkinson, Robert Johnson, Erik G Jönsson, J Wouter Jukema, René S Kahn, Ryota Kanai, Iwona Kloszewska, David S Knopman, Peter Kochunov, John B Kwok, Stephen M Lawrie, Hervé Lemaître, Xinmin Liu, Dan L Longo, W T Longstreth, Oscar L Lopez, Simon Lovestone, Oliver Martinez, Jean-Luc Martinot, Venkata S Mattay, Colm McDonald, Andrew M McIntosh, Katie L McMahon, Francis J McMahon, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Sebastian Mohnke, Grant W Montgomery, Derek W Morris, Thomas H Mosley, Thomas W Mühleisen, Bertram Müller-Myhsok, Michael A Nalls, Matthias Nauck, Thomas E Nichols, Wiro J Niessen, Markus M Nöthen, Lars Nyberg, Kazutaka Ohi, Rene L Olvera, Roel A Ophoff, Massimo Pandolfo, Tomas Paus, Zdenka Pausova, Brenda W J H Penninx, G Bruce Pike, Steven G Potkin, Bruce M Psaty, Simone Reppermund, Marcella Rietschel, Joshua L Roffman, Nina Romanczuk-Seiferth, Jerome I Rotter, Mina Ryten, Ralph L Sacco, Perminder S Sachdev, Andrew J Saykin, Reinhold Schmidt, Peter R Schofield, Sigurdur Sigurdsson, Andy Simmons, Andrew Singleton, Sanjay M Sisodiya, Colin Smith, Jordan W Smoller, Hilkka Soininen, Velandai Srikanth, Vidar M Steen, David J Stott, Jessika E Sussmann, Anbupalam Thalamuthu, Henning Tiemeier, Arthur W Toga, Bryan J Traynor, Juan Troncoso, Jessica A Turner, Christophe Tzourio, Andre G Uitterlinden, Maria C Valdés Hernández, Marcel Van der Brug, Aad Van der Lugt, Nic J A Van der Wee, Cornelia M Van Duijn, Neeltje E M Van Haren, Dennis Van T Ent, Marie-Jose Van Tol, Badri N Vardarajan, Dick J Veltman, Meike W Vernooij, Henry Völzke, Henrik Walter, Joanna M Wardlaw, Thomas H Wassink, Michael E Weale, Daniel R Weinberger, Michael W Weiner, Wei Wen, Eric Westman, Tonya White, Tien Y Wong, Clinton B Wright, H Ronald Zielke, Alan B Zonderman, Ian J Deary, Charles DeCarli, Helena Schmidt, Nicholas G Martin, Anton J M De Craen, Margaret J Wright, Lenore J Launer, Gunter Schumann, Myriam Fornage, Barbara Franke, Stéphanie Debette, Sarah E Medland, M Arfan Ikram, Paul M Thompson
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height...
December 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27613854/morphometricity-as-a-measure-of-the-neuroanatomical-signature-of-a-trait
#3
Mert R Sabuncu, Tian Ge, Avram J Holmes, Jordan W Smoller, Randy L Buckner, Bruce Fischl
Complex physiological and behavioral traits, including neurological and psychiatric disorders, often associate with distributed anatomical variation. This paper introduces a global metric, called morphometricity, as a measure of the anatomical signature of different traits. Morphometricity is defined as the proportion of phenotypic variation that can be explained by macroscopic brain morphology. We estimate morphometricity via a linear mixed-effects model that uses an anatomical similarity matrix computed based on measurements derived from structural brain MRI scans...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27609239/predicting-suicidal-behavior-from-longitudinal-electronic-health-records
#4
Yuval Barak-Corren, Victor M Castro, Solomon Javitt, Alison G Hoffnagle, Yael Dai, Roy H Perlis, Matthew K Nock, Jordan W Smoller, Ben Y Reis
OBJECTIVE: The purpose of this article was to determine whether longitudinal historical data, commonly available in electronic health record (EHR) systems, can be used to predict patients' future risk of suicidal behavior. METHOD: Bayesian models were developed using a retrospective cohort approach. EHR data from a large health care database spanning 15 years (1998-2012) of inpatient and outpatient visits were used to predict future documented suicidal behavior (i...
September 9, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27439997/cross-phenotype-polygenic-risk-score-analysis-of-persistent-post-concussive-symptoms-in-u-s-army-soldiers-with-deployment-acquired-traumatic-brain-injury
#5
Renato Polimanti, Chia-Yen Chen, Robert J Ursano, Steven G Heeringa, Sonia Jain, Ronald C Kessler, Matthew K Nock, Jordan Smoller, Xiaoying Sun, Joel Gelernter, Murray B Stein
Traumatic brain injury (TBI) contributes to the increased rates of suicide and post-traumatic stress disorder in military personnel and veterans; and it is also associated with the risk of neurodegenerative and psychiatric disorders. A cross-phenotype high-resolution polygenic risk score (PRS) analysis of persistent post-concussive symptoms (PCS) was conducted in 845 U.S. Army soldiers who sustained TBI during their deployment. We used a prospective longitudinal survey of three Brigade Combat Teams to assess deployment-acquired TBI and persistent physical, cognitive, and emotional PCS...
July 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27385740/polygenic-risk-of-alzheimer-disease-is-associated-with-early-and-late-life-processes
#6
Elizabeth C Mormino, Reisa A Sperling, Avram J Holmes, Randy L Buckner, Philip L De Jager, Jordan W Smoller, Mert R Sabuncu
OBJECTIVE: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS: We computed polygenic risk scores (PGRS) using summary statistics from the International Genomics of Alzheimer's Project genome-wide association study of AD. Associations between PGRS and AD markers (cognitive decline, clinical progression, hippocampus volume, and β-amyloid) were assessed within older participants with dementia...
August 2, 2016: Neurology
https://www.readbyqxmd.com/read/27294961/implementation-of-electronic-consent-at-a-biobank-an-opportunity-for-precision-medicine-research
#7
Natalie T Boutin, Kathleen Mathieu, Alison G Hoffnagle, Nicole L Allen, Victor M Castro, Megan Morash, P Pearl O'Rourke, Elizabeth L Hohmann, Neil Herring, Lynn Bry, Susan A Slaugenhaupt, Elizabeth W Karlson, Scott T Weiss, Jordan W Smoller
The purpose of this study is to characterize the potential benefits and challenges of electronic informed consent (eIC) as a strategy for rapidly expanding the reach of large biobanks while reducing costs and potentially enhancing participant engagement. The Partners HealthCare Biobank (Partners Biobank) implemented eIC tools and processes to complement traditional recruitment strategies in June 2014. Since then, the Partners Biobank has rigorously collected and tracked a variety of metrics relating to this novel recruitment method...
2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27167565/genome-wide-association-studies-of-posttraumatic-stress-disorder-in-2-cohorts-of-us-army-soldiers
#8
Murray B Stein, Chia-Yen Chen, Robert J Ursano, Tianxi Cai, Joel Gelernter, Steven G Heeringa, Sonia Jain, Kevin P Jensen, Adam X Maihofer, Colter Mitchell, Caroline M Nievergelt, Matthew K Nock, Benjamin M Neale, Renato Polimanti, Stephan Ripke, Xiaoying Sun, Michael L Thomas, Qian Wang, Erin B Ware, Susan Borja, Ronald C Kessler, Jordan W Smoller
IMPORTANCE: Posttraumatic stress disorder (PTSD) is a prevalent, serious public health concern, particularly in the military. The identification of genetic risk factors for PTSD may provide important insights into the biological foundation of vulnerability and comorbidity. OBJECTIVE: To discover genetic loci associated with the lifetime risk for PTSD in 2 cohorts from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). DESIGN, SETTING, AND PARTICIPANTS: Two coordinated genome-wide association studies of mental health in the US military contributed participants...
July 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27159506/genome-wide-association-study-of-generalized-anxiety-symptoms-in-the-hispanic-community-health-study-study-of-latinos
#9
Erin C Dunn, Tamar Sofer, Linda C Gallo, Stephanie M Gogarten, Kathleen F Kerr, Chia-Yen Chen, Murray B Stein, Robert J Ursano, Xiuqing Guo, Yucheng Jia, Qibin Qi, Jerome I Rotter, Maria Argos, Jianwen Cai, Frank J Penedo, Krista Perreira, Sylvia Wassertheil-Smoller, Jordan W Smoller
Although generalized anxiety disorder (GAD) is heritable and aggregates in families, no genomic loci associated with GAD have been reported. We aimed to discover potential loci by conducting a genome-wide analysis of GAD symptoms in a large, population-based sample of Hispanic/Latino adults. Data came from 12,282 participants (aged 18-74) in the Hispanic Community Health Study/Study of Latinos. Using a shortened Spielberger Trait Anxiety measure, we analyzed the following: (i) a GAD symptoms score restricted to the three items tapping diagnostic features of GAD as defined by DSM-V; and (ii) a total trait anxiety score based on summing responses to all ten items...
May 9, 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27138112/comt-val-158-met-genotype-is-associated-with-reward-learning-a-replication-study-and-meta-analysis
#10
N S Corral-Frías, D A Pizzagalli, J M Carré, L J Michalski, Y S Nikolova, R H Perlis, J Fagerness, M R Lee, E Drabant Conley, T M Lancaster, S Haddad, A Wolf, J W Smoller, A R Hariri, R Bogdan
Identifying mechanisms through which individual differences in reward learning emerge offers an opportunity to understand both a fundamental form of adaptive responding as well as etiological pathways through which aberrant reward learning may contribute to maladaptive behaviors and psychopathology. One candidate mechanism through which individual differences in reward learning may emerge is variability in dopaminergic reinforcement signaling. A common functional polymorphism within the catechol-O-methyl transferase gene (COMT; rs4680, Val(158) Met) has been linked to reward learning, where homozygosity for the Met allele (linked to heightened prefrontal dopamine function and decreased dopamine synthesis in the midbrain) has been associated with relatively increased reward learning...
June 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27053210/individual-differences-in-cognitive-control-circuit-anatomy-link-sensation-seeking-impulsivity-and-substance-use
#11
Avram J Holmes, Marisa O Hollinshead, Joshua L Roffman, Jordan W Smoller, Randy L Buckner
UNLABELLED: Individuals vary widely in their tendency to seek stimulation and act impulsively, early developing traits with genetic origins. Failures to regulate these behaviors increase risk for maladaptive outcomes including substance abuse. Here, we explored the neuroanatomical correlates of sensation seeking and impulsivity in healthy young adults. Our analyses revealed links between sensation seeking and reduced cortical thickness that were preferentially localized to regions implicated in cognitive control, including anterior cingulate and middle frontal gyrus (n = 1015)...
April 6, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27038408/genome-wide-association-study-gwas-and-genome-wide-by-environment-interaction-study-gweis-of-depressive-symptoms-in-african-american-and-hispanic-latina-women
#12
Erin C Dunn, Anna Wiste, Farid Radmanesh, Lynn M Almli, Stephanie M Gogarten, Tamar Sofer, Jessica D Faul, Sharon L R Kardia, Jennifer A Smith, David R Weir, Wei Zhao, Thomas W Soare, Saira S Mirza, Karin Hek, Henning Tiemeier, Joseph S Goveas, Gloria E Sarto, Beverly M Snively, Marilyn Cornelis, Karestan C Koenen, Peter Kraft, Shaun Purcell, Kerry J Ressler, Jonathan Rosand, Sylvia Wassertheil-Smoller, Jordan W Smoller
BACKGROUND: Genome-wide association studies (GWAS) have made little progress in identifying variants linked to depression. We hypothesized that examining depressive symptoms and considering gene-environment interaction (GxE) might improve efficiency for gene discovery. We therefore conducted a GWAS and genome-wide by environment interaction study (GWEIS) of depressive symptoms. METHODS: Using data from the SHARe cohort of the Women's Health Initiative, comprising African Americans (n = 7,179) and Hispanics/Latinas (n = 3,138), we examined genetic main effects and GxE with stressful life events and social support...
April 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/26903402/common-measures-for-national-institute-of-mental-health-funded-research
#13
Deanna M Barch, Ian H Gotlib, Robert M Bilder, Daniel S Pine, Jordan W Smoller, C Hendricks Brown, Wayne Huggins, Carol Hamilton, Adam Haim, Gregory K Farber
No abstract text is available yet for this article.
June 15, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/26886469/attention-bias-to-emotional-faces-varies-by-iq-and-anxiety-in-williams-syndrome
#14
Lauren M McGrath, Joyce M Oates, Yael G Dai, Helen F Dodd, Jessica Waxler, Caitlin C Clements, Sydney Weill, Alison Hoffnagle, Erin Anderson, Rebecca MacRae, Jennifer Mullett, Christopher J McDougle, Barbara R Pober, Jordan W Smoller
Individuals with Williams syndrome (WS) often experience significant anxiety. A promising approach to anxiety intervention has emerged from cognitive studies of attention bias to threat. To investigate the utility of this intervention in WS, this study examined attention bias to happy and angry faces in individuals with WS (N = 46). Results showed a significant difference in attention bias patterns as a function of IQ and anxiety. Individuals with higher IQ or higher anxiety showed a significant bias toward angry, but not happy faces, whereas individuals with lower IQ or lower anxiety showed the opposite pattern...
June 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/26854805/genetic-influences-on-schizophrenia-and-subcortical-brain-volumes-large-scale-proof-of-concept
#15
Barbara Franke, Jason L Stein, Stephan Ripke, Verneri Anttila, Derrek P Hibar, Kimm J E van Hulzen, Alejandro Arias-Vasquez, Jordan W Smoller, Thomas E Nichols, Michael C Neale, Andrew M McIntosh, Phil Lee, Francis J McMahon, Andreas Meyer-Lindenberg, Manuel Mattheisen, Ole A Andreassen, Oliver Gruber, Perminder S Sachdev, Roberto Roiz-Santiañez, Andrew J Saykin, Stefan Ehrlich, Karen A Mather, Jessica A Turner, Emanuel Schwarz, Anbupalam Thalamuthu, Yin Yao, Yvonne Y W Ho, Nicholas G Martin, Margaret J Wright, Michael C O'Donovan, Paul M Thompson, Benjamin M Neale, Sarah E Medland, Patrick F Sullivan
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects)...
March 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/26806518/genetic-variants-associated-with-response-to-lithium-treatment-in-bipolar-disorder-a-genome-wide-association-study
#16
MULTICENTER STUDY
Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Bárbara Arias, Lena Backlund, Claudio E M Banzato, Antoni Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M Biernacka, Armin Birner, Clara Brichant-Petitjean, Elise T Bui, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R Clark, Francesc Colom, David A Cousins, Cristiana Cruceanu, Piotr M Czerski, Clarissa R Dantas, Alexandre Dayer, Bruno Étain, Peter Falkai, Andreas J Forstner, Louise Frisén, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Carlos A López Jaramillo, Glenda MacQueen, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Michael J McCarthy, Susan L McElroy, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Urban Ösby, Norio Ozaki, Roy H Perlis, Andrea Pfennig, Daniela Reich-Erkelenz, Guy A Rouleau, Peter R Schofield, K Oliver Schubert, Barbara W Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M Slaney, Jordan W Smoller, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Julia Volkert, Stephanie Witt, Adam Wright, L Trevor Young, Peter P Zandi, James B Potash, J Raymond DePaulo, Michael Bauer, Eva Z Reininghaus, Tomas Novák, Jean-Michel Aubry, Mario Maj, Bernhard T Baune, Philip B Mitchell, Eduard Vieta, Mark A Frye, Janusz K Rybakowski, Po-Hsiu Kuo, Tadafumi Kato, Maria Grigoroiu-Serbanescu, Andreas Reif, Maria Del Zompo, Frank Bellivier, Martin Schalling, Naomi R Wray, John R Kelsoe, Martin Alda, Marcella Rietschel, Francis J McMahon, Thomas G Schulze
BACKGROUND: Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. METHODS: Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen)...
March 12, 2016: Lancet
https://www.readbyqxmd.com/read/26805891/an-emerge-clinical-center-at-partners-personalized-medicine
#17
Jordan W Smoller, Elizabeth W Karlson, Robert C Green, Sekar Kathiresan, Daniel G MacArthur, Michael E Talkowski, Shawn N Murphy, Scott T Weiss
The integration of electronic medical records (EMRs) and genomic research has become a major component of efforts to advance personalized and precision medicine. The Electronic Medical Records and Genomics (eMERGE) network, initiated in 2007, is an NIH-funded consortium devoted to genomic discovery and implementation research by leveraging biorepositories linked to EMRs. In its most recent phase, eMERGE III, the network is focused on facilitating implementation of genomic medicine by detecting and disclosing rare pathogenic variants in clinically relevant genes...
2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26658930/enigma-and-the-individual-predicting-factors-that-affect-the-brain-in-35-countries-worldwide
#18
Paul M Thompson, Ole A Andreassen, Alejandro Arias-Vasquez, Carrie E Bearden, Premika S Boedhoe, Rachel M Brouwer, Randy L Buckner, Jan K Buitelaar, Kazima B Bulayeva, Dara M Cannon, Ronald A Cohen, Patricia J Conrod, Anders M Dale, Ian J Deary, Emily L Dennis, Marcel A de Reus, Sylvane Desrivieres, Danai Dima, Gary Donohoe, Simon E Fisher, Jean-Paul Fouche, Clyde Francks, Sophia Frangou, Barbara Franke, Habib Ganjgahi, Hugh Garavan, David C Glahn, Hans J Grabe, Tulio Guadalupe, Boris A Gutman, Ryota Hashimoto, Derrek P Hibar, Dominic Holland, Martine Hoogman, Hilleke E Hulshoff Pol, Norbert Hosten, Neda Jahanshad, Sinead Kelly, Peter Kochunov, William S Kremen, Phil H Lee, Scott Mackey, Nicholas G Martin, Bernard Mazoyer, Colm McDonald, Sarah E Medland, Rajendra A Morey, Thomas E Nichols, Tomas Paus, Zdenka Pausova, Lianne Schmaal, Gunter Schumann, Li Shen, Sanjay M Sisodiya, Dirk J A Smit, Jordan W Smoller, Dan J Stein, Jason L Stein, Roberto Toro, Jessica A Turner, Martijn P van den Heuvel, Odile L van den Heuvel, Theo G M van Erp, Daan van Rooij, Dick J Veltman, Henrik Walter, Yalin Wang, Joanna M Wardlaw, Christopher D Whelan, Margaret J Wright, Jieping Ye
In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects...
December 4, 2015: NeuroImage
https://www.readbyqxmd.com/read/26657948/impact-of-stress-on-the-brain-pathology-treatment-and-prevention
#19
EDITORIAL
Kerry J Ressler, Jordan W Smoller
No abstract text is available yet for this article.
January 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26585216/does-developmental-timing-of-exposure-to-child-maltreatment-predict-memory-performance-in-adulthood-results-from-a-large-population-based-sample
#20
Erin C Dunn, Daniel S Busso, Miriam R Raffeld, Jordan W Smoller, Charles A Nelson, Alysa E Doyle, Gigi Luk
Although maltreatment is a known risk factor for multiple adverse outcomes across the lifespan, its effects on cognitive development, especially memory, are poorly understood. Using data from a large, nationally representative sample of young adults (Add Health), we examined the effects of physical and sexual abuse on working and short-term memory in adulthood. We examined the association between exposure to maltreatment as well as its timing of first onset after adjusting for covariates. Of our sample, 16...
January 2016: Child Abuse & Neglect
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