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Jordan Smoller

Jenna M Reinen, Oliver Y Chén, R Matthew Hutchison, B T Thomas Yeo, Kevin M Anderson, Mert R Sabuncu, Dost Öngür, Joshua L Roffman, Jordan W Smoller, Justin T Baker, Avram J Holmes
Higher-order cognition emerges through the flexible interactions of large-scale brain networks, an aspect of temporal coordination that may be impaired in psychosis. Here, we map the dynamic functional architecture of the cerebral cortex in healthy young adults, leveraging this atlas of transient network configurations (states), to identify state- and network-specific disruptions in patients with schizophrenia and psychotic bipolar disorder. We demonstrate that dynamic connectivity profiles are reliable within participants, and can act as a fingerprint, identifying specific individuals within a larger group...
March 20, 2018: Nature Communications
Jordan W Smoller, Ole A Andreassen, Howard J Edenberg, Stephen V Faraone, Stephen J Glatt, Kenneth S Kendler
In the Table 1 legend, the reference numbers and symbols were not correctly presented in the footnotes. The corrected footnotes are presented below.
March 14, 2018: Molecular Psychiatry
Murray B Stein, Michael J McCarthy, Chia-Yen Chen, Sonia Jain, Joel Gelernter, Feng He, Steven G Heeringa, Ronald C Kessler, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Gary H Wynn, Jordan W Smoller, Robert J Ursano
Insomnia is a worldwide problem with substantial deleterious health effects. Twin studies have shown a heritable basis for various sleep-related traits, including insomnia, but robust genetic risk variants have just recently begun to be identified. We conducted genome-wide association studies (GWAS) of soldiers in the Army Study To Assess Risk and Resilience in Servicemembers (STARRS). GWAS were carried out separately for each ancestral group (EUR, AFR, LAT) using logistic regression for each of the STARRS component studies (including 3,237 cases and 14,414 controls), and then meta-analysis was conducted across studies and ancestral groups...
March 8, 2018: Molecular Psychiatry
Erin C Dunn, Tamar Sofer, Min-Jung Wang, Thomas W Soare, Linda C Gallo, Stephanie M Gogarten, Kathleen F Kerr, Chia-Yen Chen, Murray B Stein, Robert J Ursano, Xiuqing Guo, Yucheng Jia, Jie Yao, Jerome I Rotter, Maria Argos, Jianwen Cai, Krista Perreira, Sylvia Wassertheil-Smoller, Jordan W Smoller
Although genome-wide association studies (GWAS) have identified several variants linked to depression, few GWAS of non-European populations have been performed. We conducted a genome-wide analysis of depression in a large, population-based sample of Hispanics/Latinos. Data came from 12,310 adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Past-week depressive symptoms were assessed using the 10-item Center for Epidemiological Studies of Depression Scale. Three phenotypes were examined: a total depression score, a total score modified to account for psychiatric medication use, and a score excluding anti-depressant medication users...
December 16, 2017: Journal of Psychiatric Research
Zhaozhong Zhu, Verneri Anttila, Jordan W Smoller, Phil H Lee
Advances in recent genome wide association studies (GWAS) suggest that pleiotropic effects on human complex traits are widespread. A number of classic and recent meta-analysis methods have been used to identify genetic loci with pleiotropic effects, but the overall performance of these methods is not well understood. In this work, we use extensive simulations and case studies of GWAS datasets to investigate the power and type-I error rates of ten meta-analysis methods. We specifically focus on three conditions commonly encountered in the studies of multiple traits: (1) extensive heterogeneity of genetic effects; (2) characterization of trait-specific association; and (3) inflated correlation of GWAS due to overlapping samples...
2018: PloS One
Qiu-Yue Zhong, Bizu Gelaye, Jordan W Smoller, Paul Avillach, Tianxi Cai, Michelle A Williams
OBJECTIVE: The effects of suicidal behavior on obstetric outcomes remain dangerously unquantified. We sought to report on the risk of adverse obstetric outcomes for US women with suicidal behavior at the time of delivery. METHODS: We performed a cross-sectional analysis of delivery hospitalizations from 2007-2012 National (Nationwide) Inpatient Sample. From the same hospitalization record, International Classification of Diseases codes were used to identify suicidal behavior and adverse obstetric outcomes...
2018: PloS One
Sylvia Wassertheil-Smoller, Qibin Qi, Tushar Dave, Braxton D Mitchell, Rebecca D Jackson, Simin Liu, Ki Park, Joel Salinas, Erin C Dunn, Enrique C Leira, Huichun Xu, Kathleen Ryan, Jordan W Smoller
BACKGROUND AND PURPOSE: Although depression is a risk factor for stroke in large prospective studies, it is unknown whether these conditions have a shared genetic basis. METHODS: We applied a polygenic risk score (PRS) for major depressive disorder derived from European ancestry analyses by the Psychiatric Genomics Consortium to a genome-wide association study of ischemic stroke in the Stroke Genetics Network of National Institute of Neurological Disorders and Stroke...
February 8, 2018: Stroke; a Journal of Cerebral Circulation
Tian Ge, Chia-Yen Chen, Benjamin M Neale, Mert R Sabuncu, Jordan W Smoller
[This corrects the article DOI: 10.1371/journal.pgen.1006711.].
February 2018: PLoS Genetics
Jordan W Smoller, Ole A Andreassen, Howard J Edenberg, Stephen V Faraone, Stephen J Glatt, Kenneth S Kendler
For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to define categorical syndromes based on clusters of symptoms and signs, and, to some extent, external validators, such as longitudinal course and response to treatment. In the absence of an established etiology, psychiatry has struggled to validate these descriptive syndromes, and to define the boundaries between disorders and between normal and pathologic variation...
January 9, 2018: Molecular Psychiatry
Robyn Fossey, David Kochan, Erin Winkler, Joel E Pacyna, Janet Olson, Stephen Thibodeau, John J Connolly, Margaret Harr, Meckenzie A Behr, Cynthia A Prows, Beth Cobb, Melanie F Myers, Nancy D Leslie, Bahram Namjou-Khales, Hila Milo Rasouly, Julia Wynn, Alexander Fedotov, Wendy K Chung, Ali Gharavi, Janet L Williams, Lynn Pais, Ingrid Holm, Sharon Aufox, Maureen E Smith, Aaron Scrol, Kathleen Leppig, Gail P Jarvik, Georgia L Wiesner, Rongling Li, Mary Stroud, Jordan W Smoller, Richard R Sharp, Iftikhar J Kullo
We examined the Institutional Review Board (IRB) process at 9 academic institutions in the electronic Medical Records and Genomics (eMERGE) Network, for proposed electronic health record-based genomic medicine studies, to identify common questions and concerns. Sequencing of 109 disease related genes and genotyping of 14 actionable variants is being performed in ~28,100 participants from the 9 sites. Pathogenic/likely pathogenic variants in actionable genes are being returned to study participants. We examined each site's research protocols, informed-consent materials, and interactions with IRB staff...
January 3, 2018: Journal of Personalized Medicine
Tian Ge, Avram J Holmes, Randy L Buckner, Jordan W Smoller, Mert R Sabuncu
No abstract text is available yet for this article.
December 29, 2017: Proceedings of the National Academy of Sciences of the United States of America
Jordan W Smoller
No abstract text is available yet for this article.
November 2017: Harvard Review of Psychiatry
Gabriëlla A M Blokland, Elisabetta C Del Re, Raquelle I Mesholam-Gately, Jorge Jovicich, Joey W Trampush, Matcheri S Keshavan, Lynn E DeLisi, James T R Walters, Jessica A Turner, Anil K Malhotra, Todd Lencz, Martha E Shenton, Aristotle N Voineskos, Dan Rujescu, Ina Giegling, René S Kahn, Joshua L Roffman, Daphne J Holt, Stefan Ehrlich, Zora Kikinis, Paola Dazzan, Robin M Murray, Marta Di Forti, Jimmy Lee, Kang Sim, Max Lam, Rick P F Wolthusen, Sonja M C de Zwarte, Esther Walton, Donna Cosgrove, Sinead Kelly, Nasim Maleki, Lisa Osiecki, Marco M Picchioni, Elvira Bramon, Manuela Russo, Anthony S David, Valeria Mondelli, Antje A T S Reinders, M Aurora Falcone, Annette M Hartmann, Bettina Konte, Derek W Morris, Michael Gill, Aiden P Corvin, Wiepke Cahn, New Fei Ho, Jian Jun Liu, Richard S E Keefe, Randy L Gollub, Dara S Manoach, Vince D Calhoun, S Charles Schulz, Scott R Sponheim, Donald C Goff, Stephen L Buka, Sara Cherkerzian, Heidi W Thermenos, Marek Kubicki, Paul G Nestor, Erin W Dickie, Evangelos Vassos, Simone Ciufolini, Tiago Reis Marques, Nicolas A Crossley, Shaun M Purcell, Jordan W Smoller, Neeltje E M van Haren, Timothea Toulopoulou, Gary Donohoe, Jill M Goldstein, Larry J Seidman, Robert W McCarley, Tracey L Petryshen
BACKGROUND: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection. METHODS: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia...
October 3, 2017: Schizophrenia Research
Patrick F Sullivan, Arpana Agrawal, Cynthia M Bulik, Ole A Andreassen, Anders D Børglum, Gerome Breen, Sven Cichon, Howard J Edenberg, Stephen V Faraone, Joel Gelernter, Carol A Mathews, Caroline M Nievergelt, Jordan W Smoller, Michael C O'Donovan
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. This global effort is dedicated to rapid progress and open science, and in the past decade it has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders. The PGC has recently commenced a program of research designed to deliver "actionable" findings-genomic results that 1) reveal fundamental biology, 2) inform clinical practice, and 3) deliver new therapeutic targets...
October 3, 2017: American Journal of Psychiatry
Murray B Stein, Erin B Ware, Colter Mitchell, Chia-Yen Chen, Susan Borja, Tianxi Cai, Catherine L Dempsey, Carol S Fullerton, Joel Gelernter, Steven G Heeringa, Sonia Jain, Ronald C Kessler, James A Naifeh, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Jean C Beckham, Nathan A Kimbrel, Robert J Ursano, Jordan W Smoller
Suicide is a global public health problem with particular resonance for the US military. Genetic risk factors for suicidality are of interest as indicators of susceptibility and potential targets for intervention. We utilized population-based nonclinical cohorts of US military personnel (discovery: N = 473 cases and N = 9778 control subjects; replication: N = 135 cases and N = 6879 control subjects) and a clinical case-control sample of recent suicide attempters (N = 51 cases and N = 112 control subjects) to conduct GWAS of suicide attempts (SA)...
December 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Daniel Cummings, Kevin F Dowling, Noah J Silverstein, Alexandra S Tanner, Hamdi Eryilmaz, Jordan W Smoller, Joshua L Roffman
Since 1998, the U.S. has mandated folic acid (FA) fortification of certain grain products to reduce the risk of neural tube defects. Folate intake and red blood cell (RBC) folate concentrations increased substantially post-intervention, although recent studies raise concerns about the level of ongoing benefit. This study investigated blood folate level determinants in healthy young adults, including intake of naturally occurring food folate, synthetic FA, and the interaction of naturally occurring food folate with a common missense variant in the FOLH1 gene thought to affect absorption...
September 8, 2017: Nutrients
Jordan W Smoller
The widespread adoption of electronic health record (EHRs) in healthcare systems has created a vast and continuously growing resource of clinical data and provides new opportunities for population-based research. In particular, the linking of EHRs to biospecimens and genomic data in biobanks may help address what has become a rate-limiting study for genetic research: the need for large sample sizes. The principal roadblock to capitalizing on these resources is the need to establish the validity of phenotypes extracted from the EHR...
May 30, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Murray B Stein, Chia-Yen Chen, Sonia Jain, Kevin P Jensen, Feng He, Steven G Heeringa, Ronald C Kessler, Adam Maihofer, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Michael L Thomas, Robert J Ursano, Jordan W Smoller, Joel Gelernter
No abstract text is available yet for this article.
June 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Jordan W Smoller
No abstract text is available yet for this article.
June 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Tian Ge, Avram J Holmes, Randy L Buckner, Jordan W Smoller, Mert R Sabuncu
Heritability, defined as the proportion of phenotypic variation attributable to genetic variation, provides important information about the genetic basis of a trait. Existing heritability analysis methods do not discriminate between stable effects (e.g., due to the subject's unique environment) and transient effects, such as measurement error. This can lead to misleading assessments, particularly when comparing the heritability of traits that exhibit different levels of reliability. Here, we present a linear mixed effects model to conduct heritability analyses that explicitly accounts for intrasubject fluctuations (e...
May 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
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