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https://www.readbyqxmd.com/read/27860388/enhanced-tissue-remodeling-efficacy-of-adipose-derived-mesenchymal-stem-cells-using-injectable-matrices-in-radiation-damaged-salivary-gland-model
#1
Jeong-Seok Choi, Hye-Young An, Hyun-Soo Shin, Young-Mo Kim, Jae-Yol Lim
The present study was conducted to introduce the use of a delivery carrier for local transplantation of human adipose tissue-derived mesenchymal stem cells (AdMSCs) into the salivary gland (SG) and analyze its ability to enhance radioprotection of AdMSCs against irradiation (IR)-induced damage. An injectable porcine small intestinal submucosa (SIS) matrix was used as a cell delivery carrier and human AdMSCs were contained within SIS hydrogel (AdMSC/SIS). After local injection into SGs of mice following local IR, morphological and functional changes were evaluated in the sham, vehicle (PBS), SIS, AdMSC, and AdMSC/SIS groups...
November 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27806766/-effect-of-autonomic-denervation-on-the-secretory-function-of-submandibular-glands
#2
X M Zhang, L L Wu, G Y Yu, Y Zhang
Submandibular gland is innervated by sympathetic and parasympathetic nerves, both of which work synergistically to promote the salivation of the glands. However, denervation does not always produce an inhibitive effect. Regeneration secretion was put forward to describe the situation in which the glands after denervation were found to be supersensitive to the stimulation of several agonists of saliva secretion-related receptors. It is of clinical significance to get a good understanding of the secretory mechanism changes in the autonomically denervated submandibular gland...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27759834/application-of-botulinum-toxin-to-treat-sialorrhea-in-amyotrophic-lateral-sclerosis-patients-a-literature-review
#3
Ademar Francisco de Oliveira, Gêssyca Adryene de Menezes Silva, Débora Milenna Xavier Almeida
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately 50% of amyotrophic lateral sclerosis cases. Thus, some alternative therapeutic methods are sought, such as anticholinergic drugs and surgery. Recently the use of botulinum toxin applied at a midpoint of the salivary glands, often guided by ultrasound, have demonstrated positive results...
July 2016: Einstein
https://www.readbyqxmd.com/read/27725850/effect-of-paeoniflorin-on-the-calcium-ion-concentration-in-salivary-gland-cells-using-confocal-laser-scanning-microscopy
#4
Xian Qian, Xiaolu Shi, Hongyi Wang
OBJECTIVE: To investigate the effects of paeoniflorin, the main monomer component of Jinxueyuan granules, on the Ca(2+) concentrations in salivary gland cells to further explore the salivation-promoting mechanism and effective monomer components of Jinxueyuan granules. METHODS: The salivary gland cells of suckling rats were cultured in vitro and loaded with a Fluo-3AM fluorescent probe, and changes in the intracellular Ca(2+) concentrations were observed using a confocal laser scanning microscope...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27688415/the-effect-of-tobacco-smoking-on-salivation
#5
Nikolina Petrušić, Martina Posavac, Ivan Sabol, Marinka Mravak-Stipetić
AIM: The purpose of this study was to examine the detrimental effect of smoking on the function of the salivary glands. MATERIAL AND METHODS: The study was conducted on 60 patients who were divided into two groups: a test group which included smokers and control group represented by non-smokers. Each group included 30 patients. General information was collected from all the respondents via a questionnaire as well as the data on the duration of smoking and number of cigarettes smoked per day...
December 2015: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/27616555/a-case-of-acute-postoperative-transitory-sialadenosis-of-the-submandibular-glands-in-a-healthy-dog
#6
Andrea Cattai, Silvia Levorato, Paolo Franci
A 1-year-old healthy female cross-breed dog, weighing 4.5 kg, was scheduled for elective neutering. Fentanyl (5 µg/kg) and propofol (4 mg/kg) were administered intravenously (IV) to induce anesthesia, which was maintained with isoflurane and a constant fentanyl infusion rate (10 µg/kg/hr). During the recovery from the anesthesia, the presence of bilateral dense submandibular masses was recognized, as was the excessive secretion of saliva. An ultrasound examination was performed and revealed bilateral abnormally-diffused enlargement of the submandibular salivary glands...
September 11, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27612906/removal-of-unusually-large-torpedo-sialolith-from-wharton-s-duct-under-local-analgesia-a-case-report
#7
A Siddika, A M Ferdousi, S Zaman, N Shahpor
Submandibular salivary gland system is commonly affected with sialolith (calculus) and victim suffers painful acute symptoms. Sialoliths usually are of 1-15mm in size. Although rarely giant sialoliths are seen, a giant torpedo sialolith of about 41mm × 9mm within the submandibular salivary duct is reported which was removed intraorally under local analgesia. Post-operatively, within six weeks salivation through duct was evidenced showing the process of re-establishment of salivary function.
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27347918/the-effect-of-capsaicin-on-salivary-gland-dysfunction
#8
REVIEW
Yong-Hwan Shin, Jin Man Kim, Kyungpyo Park
Capsaicin (trans-8-methyl-N-vanilyl-6-nonenamide) is a unique alkaloid isolated from hot chili peppers of the capsicum family. Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands. Capsaicin has analgesic and anti-inflammatory properties in sensory neurons. Recently, increasing evidence has indicated that capsaicin also affects saliva secretion and inflammation in salivary glands...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27136365/radioprotective-effect-of-epigallocatechin-3-gallate-on-salivary-gland-dysfunction-after-radioiodine-ablation-in-a-murine-model
#9
Jeong-Seok Choi, Hye-Young An, In Suh Park, Seok-Ki Kim, Young-Mo Kim, Jae-Yol Lim
OBJECTIVES: Radioiodine (RI) therapy is known to subject cellular components of salivary glands (SG) to oxidative stress leading to SG dysfunction. However, the protective effects of antioxidants on RI-induced SG damage have not been well investigated. The authors investigated the morphometric and functional effects of epigallocatechin-3-gallate (EGCG) administered prior to RI therapy and compared this with the effects of amifostine (a well-known antioxidant) in a murine model of RI sialadenitis...
September 2016: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/26919586/pharmacological-targeting-of-histamine-h4-receptor-in-periodontal-disease
#10
J P Prestifilippo, J Fernández-Solari, D J Martinel Lamas, C E Rios, C Mohn, J C Perazzo, E S Rivera, J C Elverdin, V A Medina
OBJECTIVE: The objective of this study was to investigate whether histamine H4 receptor (H4 R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in submandibular gland (SMG), periodontal bone and gingiva. METHODS: Bilateral EP was induced for 2 weeks in anaesthetized male rats. The effect of systemic and local administration of H4 R antagonists (JNJ7777120, JNJ10191584) on histopathology and functionality of SMG, bone loss and gingival inflammation was evaluated...
July 2016: Oral Diseases
https://www.readbyqxmd.com/read/26859883/salivary-alterations-in-rats-with-experimental-chronic-kidney-disease
#11
Ana Carolina Romero, Cassia Toledo Bergamaschi, Douglas Nesadal de Souza, Fernando Neves Nogueira
OBJECTIVE: This study aimed to analyze changes in saliva composition and salivary secretion process of rats with chronic kidney disease induced by 5/6 nephrectomy to set the foundation for salivary studies related to CKD. METHODS: CKD was induced in Wistar rats via 5/6 nephrectomy. Blood and saliva samples were collected from Control, Sham and CKD groups at 8 and 12 weeks after the surgery. Salivation was stimulated via intraperitoneal injections of pilocarpine (1...
2016: PloS One
https://www.readbyqxmd.com/read/26803950/botulinum-toxin-a-injections-vs-radiotherapy-for-drooling-in-als
#12
J G Weikamp, D A X Schinagl, C C P Verstappen, H J Schelhaas, B J M de Swart, J G Kalf
OBJECTIVES: Botulinum neurotoxin (BoNT) injections in the salivary glands and radiotherapy (RT) on these glands are commonly used to alleviate severe drooling in patients with amyotrophic lateral sclerosis (ALS). This study compares BoNT type A with RT based on patient-rated evaluations. MATERIALS & METHODS: A prospective randomized controlled pilot study to compare RT (n = 10; on the parotid and the posterior part of the submandibular glands) with BoNT-A treatment (n = 10; in the parotid glands only, because of the risk of increasing oropharyngeal weakness) in patients with ALS...
September 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/26530759/novel-manganese-porphyrin-superoxide-dismutase-mimetic-widens-the-therapeutic-margin-in-a-preclinical-head-and-neck-cancer-model
#13
Kathleen A Ashcraft, Mary-Keara Boss, Artak Tovmasyan, Kingshuk Roy Choudhury, Andrew N Fontanella, Kenneth H Young, Gregory M Palmer, Samuel R Birer, Chelsea D Landon, Won Park, Shiva K Das, Tin Weitner, Huaxin Sheng, David S Warner, David M Brizel, Ivan Spasojevic, Ines Batinic-Haberle, Mark W Dewhirst
PURPOSE: To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. METHODS AND MATERIALS: Murine oral mucosa and salivary glands were treated with a range of radiation doses with or without MnBuOE to establish the dose-effect curves for mucositis and xerostomia. Radiation injury was quantified by intravital near-infrared imaging of cathepsin activity, assessment of salivation, and histologic analysis...
November 15, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26529411/adipose-mesenchymal-stem-cell-secretome-modulated-in-hypoxia-for-remodeling-of-radiation-induced-salivary-gland-damage
#14
Hye-Young An, Hyun-Soo Shin, Jeong-Seok Choi, Hun Jung Kim, Jae-Yol Lim, Young-Mo Kim
BACKGROUND AND PURPOSE: This study was conducted to determine whether a secretome from mesenchymal stem cells (MSC) modulated by hypoxic conditions to contain therapeutic factors contributes to salivary gland (SG) tissue remodeling and has the potential to improve irradiation (IR)-induced salivary hypofunction in a mouse model. MATERIALS AND METHODS: Human adipose mesenchymal stem cells (hAdMSC) were isolated, expanded, and exposed to hypoxic conditions (O2 < 5%)...
2015: PloS One
https://www.readbyqxmd.com/read/26486891/essential-role-of-carbonic-anhydrase-xii-in-secretory-gland-fluid-and-hco3-secretion-revealed-by-disease-causing-human-mutation
#15
Jeong Hee Hong, Emad Muhammad, Changyu Zheng, Eli Hershkovitz, Soliman Alkrinawi, Neta Loewenthal, Ruti Parvari, Shmuel Muallem
KEY POINTS: Fluid and HCO3 (-) secretion is essential for all epithelia; aberrant secretion is associated with several diseases. Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secretion and works by activating the ductal Cl(-) -HCO3 (-) exchanger AE2. Delivery of CA12 to salivary glands increases salivation in mice and of the human mutation CA12(E143K) markedly inhibits it. The human mutation CA12(E143K) causes disease due to aberrant CA12 glycosylation, and misfolding resulting in loss of AE2 activity...
December 15, 2015: Journal of Physiology
https://www.readbyqxmd.com/read/26373547/eosinophilia-and-parotitis-occurring-early-in-clozapine-treatment
#16
Bochra Nourhène Saguem, Saoussen Bouhlel, Chaker Ben Salem, Bechir Ben Hadj Ali
CASE PRESENTATION: Mr. S is a 32-year-old male with schizophrenia. Due to poor responses to various antipsychotic medications, he was started on clozapine with the dose titrated to 300 mg/day during a 4-week period. The weekly checks of the complete blood cell count showed gradual increases in the eosinophil count from normal values to 4320 per mm(3). Mr. S did not have any symptoms except some increased salivation. Clozapine was suspended, and eosinophils gradually began to decline to the normal range...
December 2015: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/26050968/a-rat-model-of-radiation-injury-in-the-mandibular-area
#17
Tonje Sønstevold, Anne Christine Johannessen, Linda Stuhr
BACKGROUND: Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. Injuries to the surrounding normal tissue after radiotherapy of head and neck cancer are difficult to manage. An animal model is needed to elucidate good treatment modalities. The aim of this study was to establish a rat model where a certain radiation dose gives reproducible tissue reactions in the mandibular area corresponding to injuries obtained in humans...
2015: Radiation Oncology
https://www.readbyqxmd.com/read/26006038/the-long-term-administration-of-calcineurin-inhibitors-decreases-antioxidant-enzyme-activity-in-the-rat-parotid-and-submandibular-salivary-glands
#18
Luís C Spolidorio, Bruno S Herrera, Leila S Coimbra, Cleverton R de Andrade, Denise M P Spolidorio, Carlos Rossa Junior, Marcelo N Muscará
AIMS: Calcineurin inhibitors are widely used for prevention of graft rejection and treatment of autoimmune disorders, which result in increased longevity and enhanced quality of life for patients. Unfortunately, the toxic side effects of these drugs (mainly renal, hepatic and cardiac) limit their use. In this work, we studied the effects of long-term treatment of rats with the immunosuppressant cyclosporin (CsA) or tacrolimus (Tac) on salivation, saliva composition and on the major salivary glands (parotid and submandibular) in terms of histological alterations and oxidative stress, evaluated as lipoperoxidation (thiobarbituric acid reactive species--TBARS) and antioxidant enzyme activity contents (superoxide dismutase--SOD, catalase--CAT and glutathione peroxidase--GPx)...
August 1, 2015: Life Sciences
https://www.readbyqxmd.com/read/25906316/interaction-between-innate-immunity-and-ro52-induced-antibody-causes-sj%C3%A3-gren-s-syndrome-like-disorder-in-mice
#19
Barbara M Szczerba, Paulina Kaplonek, Nina Wolska, Anna Podsiadlowska, Paulina D Rybakowska, Paromita Dey, Astrid Rasmussen, Kiely Grundahl, Kimberly S Hefner, Donald U Stone, Stephen Young, David M Lewis, Lida Radfar, R Hal Scofield, Kathy L Sivils, Harini Bagavant, Umesh S Deshmukh
OBJECTIVES: Autoantibodies reactive with Ro52 are often found in sera of patients with Sjögren's syndrome (SS). This study was undertaken to investigate the role of Ro52-induced immune responses in pathogenesis of SS. METHODS: New Zealand Mixed (NZM) 2758 mice were immunised with Ro52 in alum adjuvant. Control mice were immunised either with maltose-binding protein or injected with alum alone. Mice were monitored for anti-Ro52 antibody, sialoadenitis and pilocarpine-induced salivation...
March 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25881952/managing-excessive-saliva-with-salivary-gland-irradiation-in-patients-with-amyotrophic-lateral-sclerosis
#20
Alexander Slade, Sinisa Stanic
OBJECTIVE: A significant fraction of patients with amyotrophic lateral sclerosis (ALS) are unable to swallow saliva, which may result in the spillage of saliva outside of the oral cavity. Although anticholinergic agents and botulin toxin injections are considered the first line of treatment, they have not been effective for all patients. We performed a literature search on therapeutic salivary gland irradiation in patients with ALS. METHODS: We searched the PubMed for English language publications up to December 2014 on therapeutic salivary gland irradiation in patients with ALS...
May 15, 2015: Journal of the Neurological Sciences
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