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https://www.readbyqxmd.com/read/29160910/epithelial-disruptions-but-not-immune-cell-invasion-induced-secretory-dysfunction-following-innate-immune-activation-in-a-novel-model-of-acute-salivary-gland-injury
#1
Abeer Shaalan, Guy Carpenter, Gordon Proctor
BACKGROUND: Salivary gland (SG) injurious agents are all translated into loss of salivation (xerostomia). An association has been established between activation of innate immunity and salivary gland injury and dysfunction. However, it remains unclear how the secretory epithelia respond by halting saliva production. METHODS: C57BL/6 submandibular glands (SMGs) were acutely challenged using a single dose of the innate immune stimulant: polyinosinic-polycytidylic acid (poly (I:C))...
November 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29022754/different-protocols-of-photobiomodulation-therapy-of-hyposalivation
#2
Božana Lončar Brzak, Livia Cigić, Marinka Baričević, Ivan Sabol, Marinka Mravak-Stipetić, Dubravko Risović
AIM: Photobiomodulation (PBM) therapy has proved to be effective for a wide range of oral pathologies including oral dryness, but the literature still lacks reports of clinical trials and protocols. The purpose of our study was to evaluate the effects of different wavelengths of PBM on salivation in patients suffering from hyposalivation aiming at determination of optimal treatment protocol. MATERIALS AND METHODS: This study included 30 patients whose major salivary glands were treated with low-intensity diode laser BTL2000 (Medical Technologies, s...
October 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28818099/biosemantics-guided-gene-expression-profiling-of-sj%C3%A3-gren-s-syndrome-a-comparative-analysis-with-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#3
Nirav R Shah, Braxton D Noll, Craig B Stevens, Michael T Brennan, Farah B Mougeot, Jean-Luc C Mougeot
BACKGROUND: Sjögren's syndrome (SS) shares many clinical and pathological similarities with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). These autoimmune diseases mostly affect women. In this study, concept profile analysis (CPA) and gene expression meta-analysis were used to identify genes potentially involved in SS pathogenesis. METHODS: Human genes associated with SS, SLE, and RA were identified using the CPA tool, Anni 2.1. The differential mRNA expression of genes common to SS and SLE (SS-SLE) was determined in female peripheral blood mononuclear cells (PBMCs) using NCBI-GEO2R...
August 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28814903/ixeris-dentata-extract-regulates-salivary-secretion-through-the-activation-of-aquaporin-5-and-prevents-diabetes-induced-xerostomia
#4
Kashi Raj Bhattarai, Sang-Won Lee, Seung Hyun Kim, Hyung-Ryong Kim, Han-Jung Chae
The aim of this study was to investigate the effects of Ixeris dentata (IXD) extract to improve the salivation rate in dry mouth induced by diabetes. Both control and diabetic rats were treated with a sublingual spray of either water or IXD extract to determine the effects of IXD on salivation. During the study, we observed that IXD extract treatment increased the salivary flow rate in diabetic rats. The expression of α-amylase was increased significantly in both saliva and glandular tissue lysates of IXD-treated diabetic rats...
2017: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/28761796/the-salivary-gland-salivation-stimulating-peptide-from-locusta-migratoria-lom-sg-sasp-is-not-a-typical-neuropeptide
#5
Jan A Veenstra
The salivary gland salivation stimulating peptide was identified from the salivary glands of the migratory locust by its ability to stimulate cAMP production in the same tissue. The gene coding for this peptide has recently been identified and been shown to code for a precursor consisting of a signal peptide, several copies of the peptide separated by Lys-Arg doublets and a few other peptides. These data are consistent with it being a neuropeptide. However, antiserum raised to this peptide labels the acini of the salivary glands while RT-PCR only gives positive results in the salivary gland, but not in any ganglion of the central nervous system...
2017: PeerJ
https://www.readbyqxmd.com/read/28736624/lyme-and-dopaminergic-function-hypothesizing-reduced-reward-deficiency-symptomatology-by-regulating-dopamine-transmission
#6
Kenneth Blum, Edward J Modestino, Marcelo Febo, Bruce Steinberg, Thomas McLaughlin, Lyle Fried, David Baron, David Siwicki, Rajendra D Badgaiyan
The principal vector of Lyme disease in the United States is Ixodes scapularis: black legged or deer ticks. There is increased evidence that those infected may be plagued by anxiety or depression as well. Researchers have identified transcripts coding for two putative cytosolic sulfotransferases in these ticks, which recognized phenolic monoamines as their substrates. It is hypothesized that protracted Lyme disease sequelae may be due to impairment of dopaminergic function of the brain reward circuitry. The subsequent recombinant proteins exhibited sulfotransferase function against two neurotransmitters: dopamine and octopamine...
May 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28635876/-salivation-after-stroke
#7
Z A Zalyalova
Salivation after stroke (sialorrhea, hypersalivation, ptyalism) can be caused by the overproduction or a lack of utilization of saliva. Patients after stroke often have sialorrhea as a result of dysphagia. Neurogenic dysphagia in acute period after stroke occurs in 25-65% of patients. The mortality rate among people with post-stroke dysphagia and tube feeding ranges from 20 to 24%. Patients who suffering from profuse salivation have difficulties with articulation and swallowing, bad breath, irritation and maceration of perioral area, contamination of clothing and bed linen...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28634110/restoration-of-cftr-activity-in-ducts-rescues-acinar-cell-function-and-reduces-inflammation-in-pancreatic-and-salivary%C3%A2-glands-of-mice
#8
Mei Zeng, Mitchell Szymczak, Malini Ahuja, Changyu Zheng, Hongen Yin, William Swaim, John A Chiorini, Robert J Bridges, Shmuel Muallem
BACKGROUND & AIMS: Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoimmune pancreatitis. Cystic fibrosis transmembrane conductance regulator (CFTR) is a ductal Cl(-) channel essential for ductal fluid and HCO3(-) secretion. We used these models to ask the following questions: is CFTR expression altered in these diseases, does correction of CFTR correct gland function, and most notably, does correcting ductal function correct acinar function? METHODS: We treated the mice models with the CFTR corrector C18 and the potentiator VX770...
October 2017: Gastroenterology
https://www.readbyqxmd.com/read/28177730/impaired-mitochondria-and-intracellular-calcium-transients-in-the-salivary-glands-of-obese-rats
#9
Jitjiroj Ittichaicharoen, Nattayaporn Apaijai, Pongpan Tanajak, Piangkwan Sa-Nguanmoo, Nipon Chattipakorn, Siriporn C Chattipakorn
Long-term consumption of a high-fat diet (HFD) causes not only obese-insulin resistance, but is also associated with mitochondrial dysfunction in several organs. However, the effect of obese-insulin resistance on salivary glands has not been investigated. We hypothesized that obese-insulin resistance induced by HFD impaired salivary gland function by reducing salivation, increasing inflammation, and fibrosis, as well as impairing mitochondrial function and calcium transient signaling. Male Wistar rats (200-220 g) were fed either a ND or an HFD (n = 8/group) for 16 weeks...
April 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28118925/treatment-of-the-first-bite-syndrome
#10
María Costales-Marcos, Fernando López Álvarez, Laura Fernández-Vañes, Justo Gómez, José Luis Llorente
First bite syndrome is a potential complication of surgery involving the infratemporal fossa, deep lobe of the parotid gland and parapharyngeal space. It is described as an acute and intense pain in the parotid region caused with the first bite of each meal. It is related to damage to sympathetic innervation of the parotid gland. Parasympathetic hyperactivation is believed to stimulate an exaggerated myoepithelial cell contraction causing pain. Usual analgesic treatments have poor results. Botulinum toxin type A causes parasympathetic nerve paralysis of the parotid gland and this fact would minimize salivation and decrease first bite syndrome...
September 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28118553/endothelial-tight-junctions-are-opened-in-cholinergic-evoked-salivation-in-vivo
#11
X Cong, Y Zhang, Q H He, T Wei, X M Zhang, J Z Zhang, R L Xiang, G Y Yu, L L Wu
Blood vessels provide the original supplies for the formation of primary saliva, which is regulated by the tight junctions (TJs) between endothelial cells. Previous studies have shown that blood flow increases with vasodilatation during cholinergic-evoked salivation. However, changes in vascular paracellular permeability and the role of endothelial TJs in salivation are unknown. Here, we established an in vivo paracellular permeability detection system and observed that the endothelial TJs were permeable to 4-kDa fluorescein isothiocyanate (FITC)-dextran while impermeable to 40- and 70-kDa FITC-dextran under an unstimulated condition in mouse submandibular glands (SMGs)...
May 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28025847/metabolic-remodeling-triggered-by-salivation-and-diabetes-in-major-salivary-glands
#12
Fernando N Nogueira, Rui A Carvalho
The metabolic profile of major salivary glands was evaluated by (13) C nuclear magnetic resonance isotopomer analysis ((13) C NMR-IA) following the infusion of [U-(13) C]glucose in order to define the true metabolic character of submandibular (SM) and parotid (PA) glands at rest and during salivary stimulation, and to determine the metabolic remodeling driven by diabetes. In healthy conditions, the SM gland is characterized at rest by a glycolytic metabolic profile and extensive pyruvate cycling. On the contrary, the PA gland, although also dominated by glycolysis, also possesses significant Krebs' cycle activity and does not sustain extensive pyruvate cycling...
December 26, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27860388/enhanced-tissue-remodeling-efficacy-of-adipose-derived-mesenchymal-stem-cells-using-injectable-matrices-in-radiation-damaged-salivary-gland-model
#13
Jeong-Seok Choi, Hye-Young An, Hyun-Soo Shin, Young-Mo Kim, Jae-Yol Lim
The present study was conducted to introduce the use of a delivery carrier for local transplantation of human adipose tissue-derived mesenchymal stem cells (AdMSCs) into the salivary gland (SG) and analyze its ability to enhance radioprotection of AdMSCs against irradiation (IR)-induced damage. An injectable porcine small intestinal submucosa (SIS) matrix was used as a cell delivery carrier and human AdMSCs were contained within SIS hydrogel (AdMSC/SIS). After local injection into SGs of mice following local IR, morphological and functional changes were evaluated in the sham, vehicle (PBS), SIS, AdMSC, and AdMSC/SIS groups...
November 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27806766/-effect-of-autonomic-denervation-on-the-secretory-function-of-submandibular-glands
#14
X M Zhang, L L Wu, G Y Yu, Y Zhang
Submandibular gland is innervated by sympathetic and parasympathetic nerves, both of which work synergistically to promote the salivation of the glands. However, denervation does not always produce an inhibitive effect. Regeneration secretion was put forward to describe the situation in which the glands after denervation were found to be supersensitive to the stimulation of several agonists of saliva secretion-related receptors. It is of clinical significance to get a good understanding of the secretory mechanism changes in the autonomically denervated submandibular gland...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27759834/application-of-botulinum-toxin-to-treat-sialorrhea-in-amyotrophic-lateral-sclerosis-patients-a-literature-review
#15
REVIEW
Ademar Francisco de Oliveira, Gêssyca Adryene de Menezes Silva, Débora Milenna Xavier Almeida
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately 50% of amyotrophic lateral sclerosis cases. Thus, some alternative therapeutic methods are sought, such as anticholinergic drugs and surgery. Recently the use of botulinum toxin applied at a midpoint of the salivary glands, often guided by ultrasound, have demonstrated positive results...
July 2016: Einstein
https://www.readbyqxmd.com/read/27725850/effect-of-paeoniflorin-on-the-calcium-ion-concentration-in-salivary-gland-cells-using-confocal-laser-scanning-microscopy
#16
Xian Qian, Xiaolu Shi, Hongyi Wang
OBJECTIVE: To investigate the effects of paeoniflorin, the main monomer component of Jinxueyuan granules, on the Ca(2+) concentrations in salivary gland cells to further explore the salivation-promoting mechanism and effective monomer components of Jinxueyuan granules. METHODS: The salivary gland cells of suckling rats were cultured in vitro and loaded with a Fluo-3AM fluorescent probe, and changes in the intracellular Ca(2+) concentrations were observed using a confocal laser scanning microscope...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27688415/the-effect-of-tobacco-smoking-on-salivation
#17
Nikolina Petrušić, Martina Posavac, Ivan Sabol, Marinka Mravak-Stipetić
AIM: The purpose of this study was to examine the detrimental effect of smoking on the function of the salivary glands. MATERIAL AND METHODS: The study was conducted on 60 patients who were divided into two groups: a test group which included smokers and control group represented by non-smokers. Each group included 30 patients. General information was collected from all the respondents via a questionnaire as well as the data on the duration of smoking and number of cigarettes smoked per day...
December 2015: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/27616555/a-case-of-acute-postoperative-transitory-sialadenosis-of-the-submandibular-glands-in-a-healthy-dog
#18
Andrea Cattai, Silvia Levorato, Paolo Franci
A 1-year-old healthy female cross-breed dog, weighing 4.5 kg, was scheduled for elective neutering. Fentanyl (5 µg/kg) and propofol (4 mg/kg) were administered intravenously (IV) to induce anesthesia, which was maintained with isoflurane and a constant fentanyl infusion rate (10 µg/kg/hr). During the recovery from the anesthesia, the presence of bilateral dense submandibular masses was recognized, as was the excessive secretion of saliva. An ultrasound examination was performed and revealed bilateral abnormally-diffused enlargement of the submandibular salivary glands...
January 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27612906/removal-of-unusually-large-torpedo-sialolith-from-wharton-s-duct-under-local-analgesia-a-case-report
#19
A Siddika, A M Ferdousi, S Zaman, N Shahpor
Submandibular salivary gland system is commonly affected with sialolith (calculus) and victim suffers painful acute symptoms. Sialoliths usually are of 1-15mm in size. Although rarely giant sialoliths are seen, a giant torpedo sialolith of about 41mm × 9mm within the submandibular salivary duct is reported which was removed intraorally under local analgesia. Post-operatively, within six weeks salivation through duct was evidenced showing the process of re-establishment of salivary function.
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27347918/the-effect-of-capsaicin-on-salivary-gland-dysfunction
#20
REVIEW
Yong-Hwan Shin, Jin Man Kim, Kyungpyo Park
Capsaicin (trans-8-methyl-N-vanilyl-6-nonenamide) is a unique alkaloid isolated from hot chili peppers of the capsicum family. Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands. Capsaicin has analgesic and anti-inflammatory properties in sensory neurons. Recently, increasing evidence has indicated that capsaicin also affects saliva secretion and inflammation in salivary glands...
June 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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