Qing-Qing Zhou, Yan-Ping Wu, Pei Liu, Wen-Zhe Deng, Yu-Hui Lu, Hai-Biao Gong, Xiao-Min Lin, Wan-Yang Sun, Rong Wang, Feng Huang, Yun-Feng Cao, Yi-Fang Li, Hiroshi Kurihara, Shu-Hua Ouyang, Lei Liang, Rong-Rong He
BACKGROUND: Psychological stress is associated with various diseases including liver dysfunction, yet effective intervention strategies remain lacking due to the unrevealed pathogenesis mechanism. PURPOSE: This study aims to explore the relevance between BMAL1-controlled circadian rhythms and lipoxygenase 15 (ALOX15)-mediated phospholipids peroxidation in psychological stress-induced liver injury, and to investigate whether hepatocyte phospholipid peroxidation signaling is involved in the hepatoprotective effects of a Chinese patent medicine, Pien Tze Huang (PZH)...
April 16, 2024: Phytomedicine