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https://www.readbyqxmd.com/read/29243276/the-influence-of-shc-proteins-and-high-fat-diet-on-energy-metabolism-of-mice
#1
W A Baldassini, J J Ramsey, K Hagopian, D P D Lanna
The purpose of this study was to determine if Shc proteins influence the metabolic response to acute (7 days) feeding of a high-fat diet (HFD). To this end, whole animal energy expenditure (EE) and substrate oxidation were measured in the Shc knockout (ShcKO) and wild-type (WT) mice fed a control or HFD. The activities of enzymes of glycolysis, the citric acid cycle, electron transport chain (ETC), and β-oxidation were also investigated in liver and skeletal muscle of ShcKO and WT animals. The study showed that ShcKO increases (P < ...
December 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29243057/decreased-muscle-mass-is-independently-associated-with-knee-pain-in-female-patients-with-radiographically-mild-osteoarthritis-a-nationwide-cross-sectional-study-knhanes-2010-2011
#2
Hee Min Park, Ho Jae Kim, Byeori Lee, Minkyoung Kwon, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
To evaluate the association between muscle mass and knee pain in relation to radiographic severity of knee osteoarthritis. We consulted nationwide health examination and survey records collected from 2010 to 2011 and extracted data regarding female patients aged > 50 years and diagnosed with knee osteoarthritis. Radiographic severity was assessed on plain radiographs using the Kellgren-Lawrence system, whereas appendicular skeletal mass was obtained from dual-energy X-ray absorptiometry data. We performed multivariate logistic regression to evaluate the association between knee pain and muscle mass index (appendicular skeletal muscle mass divided by body weight in percentile) in patient groups stratified by radiographic severity of knee osteoarthritis...
December 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29242801/spindle-cell-hemangioma-of-the-midfoot-a-case-report
#3
Tanawat Vaseenon, Jirawat Saengsin, Nuttaya Pattamapaspong, Jongkolnee Settakorn, Dumnoensun Pruksakorn
Introduction: Spindle cell hemangioma (SCH) of the bone (midfoot) is a rare disease, but it can cause symptomatic pain and invade surrounding tissues lead to limb deformities and functional loss. Case Report: We report the case of a 35-year-old woman who experienced a firm mass over the left midfoot for 5 years causing pain and numbness in the foot. Radiographs showed a geographic osteolytic lesion involving calcification of the base of the 2nd and 3rd metatarsals, cuneiforms bones and surrounding soft tissue...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242526/percentiles-for-skeletal-muscle-index-area-and-radiation-attenuation-based-on-computed-tomography-imaging-in-a-healthy-caucasian-population
#4
A van der Werf, J A E Langius, M A E de van der Schueren, S A Nurmohamed, K A M I van der Pant, S Blauwhoff-Buskermolen, N J Wierdsma
BACKGROUND/OBJECTIVES: Muscle mass is a key determinant of nutritional status and associated with outcomes in several patient groups. Computed tomography (CT) analysis is increasingly used to assess skeletal muscle area (SMA), skeletal muscle index (SMI) and muscle radiation attenuation (MRA). However, interpretation of these muscle parameters is difficult since values in a healthy population are lacking. The aim of this study was to provide sex specific percentiles for SMA, SMA and MRA in a healthy Caucasian population and to examine the association with age and BMI in order to define age- and BMI specific percentiles...
December 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29242259/chest-computed-tomography-derived-low%C3%A2-fat-free-mass-index-and-mortality-in%C3%A2-copd
#5
Merry-Lynn N McDonald, Alejandro A Diaz, Erica Rutten, Sharon M Lutz, Rola Harmouche, Raul San Jose Estepar, Greg Kinney, John E Hokanson, Barbara A Gower, Emiel F M Wouters, Stephen I Rennard, Craig P Hersh, Richard Casaburi, Mark T Dransfield, Edwin K Silverman, George R Washko
Low fat-free mass index (FFMI) is an independent risk factor for mortality in chronic obstructive pulmonary disease (COPD) not typically measured during routine care. In the present study, we aimed to derive fat-free mass from the pectoralis muscle area (FFMPMA) and assess whether low FFMIPMA is associated with all-cause mortality in COPD cases. We used data from two independent COPD cohorts, ECLIPSE and COPDGene.Two equal sized groups of COPD cases (n=759) from the ECLIPSE study were used to derive and validate an equation to calculate the FFMPMA measured using bioelectrical impedance from PMA...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29241059/moxidectin-residues-in-lamb-tissues-development-and-validation-of-analytical-method-by-uhplc-ms-ms
#6
Michelle Del Bianchi A Cruz, Maria A M Fernandes, Patricia A de C Braga, Alda L G Monteiro, Daniela Daniel, Felix G R Reyes
The development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). To achieve higher recovery of the analyte from the matrices, a modified QuEChERS method was used for sample preparation. The chromatographic separation was achieved using a Zorbax Eclipse Plus C18 RRHD column with a mobile phase comprising 5mM ammonium formate solution +0...
December 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29240830/a-low-fat-diet-ameliorates-pathology-but-retains-beneficial-effects-associated-with-cpt1b-knockout-in-skeletal-muscle
#7
Jaycob D Warfel, Bolormaa Vandanmagsar, Shawna E Wicks, Jingying Zhang, Robert C Noland, Randall L Mynatt
Inhibiting fatty acid oxidation is one approach to lowering glucose levels in diabetes. Skeletal muscle specific Carnitine Palmitoyltransferase 1b knockout mice (Cpt1bm-/-) comprise a model of impaired fat oxidation; and have decreased fat mass and enhanced glucose disposal and muscle oxidative capacity compared to controls. However, unfavorable effects occur relative to controls when Cpt1bm-/- mice are fed a 25% fat diet, including decreased activity and fat free mass and increased intramuscular lipid and serum myoglobin...
2017: PloS One
https://www.readbyqxmd.com/read/29240780/filamina-and-formin2-regulate-skeletal-muscular-and-intestinal-formation-through-mesenchymal-progenitor-proliferation
#8
Gewei Lian, Sneha Kanaujia, Timothy Wong, Volney Sheen
The effects of actin dependent molecular mechanisms in coordinating cellular proliferation, migration and differentiation during embryogenesis are not well-understood. We have previously shown that actin-binding Filamin A (FlnA) and actin-nucleating Formin 2 (Fmn2) influence the development of the brain causing microcephaly in mice. In this study, we broaden this phenotype to explore the effects of these two proteins in the development of extra-CNS organ systems, including the gut, muscle, and skeleton. We observed defects in rib and sternum midline closure leading to thoracoabdominal schisis in FlnA+Fmn2 knockout mice, reminiscent of the pentalogy of Cantrell syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/29240672/amount-distribution-and-quality-of-protein-intake-are-not-associated-with-muscle-mass-strength-and-power-in-healthy-older-adults-without-functional-limitations-an-enable-study
#9
Anne Gingrich, Alexandra Spiegel, Robert Kob, Daniel Schoene, Thomas Skurk, Hans Hauner, Cornel C Sieber, Dorothee Volkert, Eva Kiesswetter
To maintain muscle mass in older age, several aspects regarding the amount and distribution of protein intake have been suggested. Our objective was to investigate single and combined associations of daily protein intake, evenness of protein distribution across the three main meals, number of meals providing ≥0.4 g protein/kg body weight (BW), and number of meals providing ≥2.5 g leucine, with muscle mass, strength, and power in successful agers. In this cross-sectional study in 97 healthy community-dwelling adults without functional limitations aged 75-85 years, protein intake was assessed using 7-day food records...
December 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29239993/hypoxia-during-resistance-exercise-does-not-affect-physical-performance-perceptual-responses-or-neuromuscular-recovery
#10
Brendan R Scott, Katie M Slattery, Dean V Sculley, Ben J Dascombe
This study aimed to determine whether performing resistance exercise in hypoxia affects markers of physical performance, perceptual responses, and neuromuscular function. Fourteen male subjects (age: 24.6 ± 2.7 yr; height: 179.7 ± 5.9 cm; body mass: 84.6 ± 11.6 kg) with >2 years resistance training experience performed moderate-load resistance exercise in two conditions; normoxia (FIO2 = 0.21) and hypoxia (FIO2 = 0.16). Resistance exercise comprised 3 sets of 10 repetitions of back squats and deadlifts at 60% of 1RM, with 60s inter-set rest...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239991/a-multiple-repeated-sprint-ability-test-with-four-changes-of-direction-for-badminton-players-part-2-predicting-skill-level-with-anthropometry-strength-shuttlecock-and-displacement-velocity
#11
Michael Phomsoupha, Guillaume Laffaye
The goal of this study was: (i) to assess general and specific lower and upper limb force, shuttlecock velocity, displacement ability and the anthropometric characteristics of badminton players at five skill levels, and (ii) to predict individual players' number of points. We divided 83 participants into groups of novice (n=15), intermediate (n=16), skilled (n=23), highly skilled (n=14) and elite (n=15) players. The number of points scored for each player performing tournaments (excluding novices) during the entire season was used as a continuous and dependent variable after logarithmic transformation for correlational study...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239855/experimental-verification-of-stopping-power-prediction-from-single-and-dual-energy-computed-tomography-in-biological-tissues
#12
Christian Möhler, Tom Russ, Patrick Wohlfahrt, Alina Elter, Armin Runz, Christian Richter, Steffen Greilich
An experimental setup for consecutive measurement of ion and x-ray absorption in tissue or other materials is introduced. With this setup using a 3D-printed sample container, the reference stopping-power ratio (SPR) of materials can be measured with an uncertainty of below 0.1%. A total of 65 porcine and bovine tissue samples were prepared for measurement, comprising five samples each of 13 tissue types representing about 80% of the total body mass (three different muscle and fatty tissues, liver, kidney, brain, heart, blood, lung and bone)...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29239712/multiparametric-mr-imaging-of-age-related-changes-in-healthy-thigh-muscles
#13
Min A Yoon, Suk-Joo Hong, Min Cheol Ku, Chang Ho Kang, Kyung-Sik Ahn, Baek Hyun Kim
Purpose To use multiparametric magnetic resonance (MR) imaging to assess for and establish age-related differences in healthy thigh muscles. Materials and Methods Ninety-five subjects (47 men, 48 women; median age, 47 years) with healthy body mass index were grouped according to age: 30-39 years (n = 25), 40-49 years (n = 25), 50-59 years (n = 25), and 60-69 years (n = 20). Multiparametric MR imaging (intravoxel incoherent motion diffusion-weighted, diffusion-tensor, multiecho Dixon, and dynamic contrast material-enhanced MR imaging) was performed at 3...
December 14, 2017: Radiology
https://www.readbyqxmd.com/read/29239490/proteomic-changes-of-the-porcine-skeletal-muscle-in-response-to-chronic-heat-stress
#14
Yanjun Cui, Yue Hao, Jielei Li, Yanli Gao, Xianhong Gu
BACKGROUND: Heat stress (HS) has an adverse effect on meat quality; yet, the underlying molecular mechanisms altering meat quality due to muscle responses to stress remain unclear. Sixteen castrated male crossbreeds between Landrace × Yorkshire sows and Duroc boars (79.00 ± 1.50 kg body weight) were exposed to either thermal neutral (22 °C, n=8) or heat stress (30 °C, n=8) conditions for 3 weeks. Subsequently, the longissimus dorsi (LD) muscle of all pigs was assayed for meat quality parameters and proteome analysis...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29239106/er-stress-in-skeletal-muscle-remodeling-and-myopathies
#15
REVIEW
Dil Afroze, Ashok Kumar
Skeletal muscle is a highly plastic tissue in the human body that undergoes extensive adaptation in response to environmental cues, such as physical activity, metabolic perturbation, and disease conditions. The endoplasmic reticulum (ER) plays a pivotal role in protein folding and calcium homeostasis in many mammalian cell types including skeletal muscle. However, overload of misfolded or unfolded proteins in the ER lumen cause stress, which results in the activation of a signaling network called the unfolded protein response (UPR)...
December 14, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29238412/oral-leiomyoma-in-an-adult-male-a-case-report
#16
Amanda Phoon Nguyen, Agnieszka M Frydrych
Introduction: Oral leiomyomas are rare, benign neoplasms of smooth muscle origin, presenting as a solitary, asymptomatic, nodular mass. Case Presentation: Here we present the case of a 54-year-old male with a lesion in the midline of his hard palate, which was diagnosed as a localized benign leiomyoma, along with a review of the recent literature. Discussion: Diagnosis of a leiomyoma must be based on the histopathological assessment of tissue as the clinical appearance is non-specific...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/29238037/the-association-of-sarcopenia-telomere-length-and-mortality-data-from-the-nhanes-1999-2002
#17
Peter L Rippberger, Rebecca T Emeny, Todd A Mackenzie, Stephen J Bartels, John A Batsis
BACKGROUND/OBJECTIVES: Sarcopenia is defined as the loss of muscle mass or function with aging and is associated with adverse outcomes. Telomere shortening is associated with mortality, yet its relationship with sarcopenia is unknown. SUBJECTS/METHODS: Adults ≥60 years from the 1999-2002 NHANES with body composition measures were identified. Sarcopenia was defined using the two Foundation for the National Institute of Health definitions: appendicular lean mass (ALM) (men <19...
December 14, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29237078/determinants-of-peripheral-muscle-strength-and-activity-in-daily-life-in-people-with-bronchiectasis
#18
Anderson Alves de Camargo, Jacqueline C Boldorini, Anne E Holland, Rejane A Silva de Castro, Fernanda de Cordoba Lanza, Rodrigo A Athanazio, Samia Z Rached, Regina Carvalho-Pinto, Alberto Cukier, Rafael Stelmach, Simone Dal Corso
Background: Bronchiectasis is characterized by a progressive structural lung damage, recurrent infections and chronic inflammation which compromise the exertion tolerance, and may have an impact on skeletal muscle function and physical function. Objective: The purpose of this study was to compare peripheral muscle strength, exercise capacity, and physical activity in daily life between participants with bronchiectasis and controls and to investigate the determinants of the peripheral muscle strength and physical activity in daily life in bronchiectasis...
December 9, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29236945/the-effect-of-increasing-age-on-the-concentric-and-eccentric-contractile-properties-of-isolated-mouse-soleus-and-extensor-digitorum-longus-muscles
#19
Cameron Hill, Rob S James, Val M Cox, Jason Tallis
There is currently a limited amount of literature investigating the age-related changes in eccentric muscle function in vitro. The present study uniquely uses the work loop technique, to better replicate in vivo muscle function, in the assessment of the age and muscle-specific changes in acute and sustained concentric and eccentric power and recovery. Whole soleus or EDL muscles were isolated from 10-week and 78-week old mice, and acute and sustained concentric and eccentric work loop power assessed. Despite an age-related increase in body and muscle mass, peak absolute power for both muscles was unaffected by age...
December 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29234186/primary-leiomyosarcoma-of-the-mesentery-a-case-report
#20
Varsha Dalal, Manveen Kaur, Reetika Menia, Fouzia Siraj, Amar Bhatnagar, Usha Agrawal
Mesenteric masses are infrequent lesions ranging from benign cysts to aggressive malignancies and often present a diagnostic and therapeutic challenge. The mesentery is a frequent recipient of metastases from the gastrointestinal tract, pancreas, and biliary cancers. Primary mesenteric tumors are relatively rare, mostly mesenchymal in origin and benign in nature. Examples include gastrointestinal stromal tumors and smooth muscle tumors. We describe a 50-year-old woman, who presented with a lump in the left hypochondrium along with altered bowel habits of 2 years' duration...
September 2017: Iranian Journal of Medical Sciences
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