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Hypertension and diet

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https://www.readbyqxmd.com/read/28430843/carotid-body-denervation-markedly-improves-survival-in-rats-with-hypertensive-heart-failure
#1
Kana Fujii, Keita Saku, Takuya Kishi, Yasuhiro Oga, Takeshi Tohyama, Takuya Nishikawa, Takafumi Sakamoto, Masataka Ikeda, Tomomi Ide, Hiroyuki Tsutsui, Kenji Sunagawa
BACKGROUND: Hypertension is a major cause of heart failure. Excessive sympathoexcitation in patients with heart failure leads to poor prognosis. Since carotid body denervation (CBD) has been shown to reduce sympathetic nerve activity in animal models of hypertension and heart failure, we examined if bilateral CBD attenuates the progression of hypertensive heart failure and improves survival. METHODS: We randomly allocated Dahl salt-sensitive rats fed a high-salt diet from 6 weeks of age into CBD (n = 31) and sham-operation (SHAM; n = 50) groups, and conducted CBD or SHAM at 7 weeks of age...
April 19, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28428143/high-quality-diets-associate-with-reduced-risk-of-colorectal-cancer-analyses-of-diet-quality-indexes-in-the-multiethnic-cohort
#2
Song-Yi Park, Carol J Boushey, Lynne R Wilkens, Christopher A Haiman, Loïc Le Marchand
BACKGROUND & AIMS: Healthy eating patterns assessed by diet quality indexes (DQIs) have been related to lower risk of colorectal cancer-mostly among whites. We investigated the associations between 4 DQI scores (the Healthy Eating Index 2010 [HEI-2010], the Alternative Healthy Eating Index 2010 [AHEI-2010], the alternate Mediterranean diet score [aMED], and the Dietary Approaches to Stop Hypertension score) and colorectal cancer risk in the Multiethnic Cohort. METHODS: We analyzed data from 190,949 African Americans, Native Hawaiians, Japanese Americans, Latinos and whites, 45-75 years old, who entered the Multiethnic Cohort study from 1993 through 1996...
April 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28428072/membrane-lipid-alterations-in-the-metabolic-syndrome-and-the-role-of-dietary-oils
#3
REVIEW
Javier S Perona
The metabolic syndrome is a cluster of pathological conditions, including hypertension, hyperglycemia, hypertriglyceridemia, obesity and low HDL levels that is of great concern worldwide, as individuals with metabolic syndrome have an increased risk of type-2 diabetes and cardiovascular disease. Insulin resistance, the key feature of the metabolic syndrome, might be at the same time cause and consequence of impaired lipid composition in plasma membranes of insulin-sensitive tissues like liver, muscle and adipose tissue...
April 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28427397/hvc1-ameliorates-hyperlipidemia-and-inflammation-in-ldlr-mice
#4
Se-Yun Cheon, Kyung-Sook Chung, Kyung-Jin Lee, Ho-Young Choi, In-Hye Ham, Dong-Hoon Jung, Yun-Yeop Cha, Hyo-Jin An
BACKGROUND: HVC1 consists of Coptidis Rhizoma (dried rhizome of Coptischinensis), Scutellariae Radix (root of Scutellariabaicalensis), Rhei Rhizoma (rhizome of Rheum officinale), and Pruni Cortex (cortex of Prunusyedoensis Matsum). Although the components are known to be effective in various conditions such as inflammation, hypertension, and hypercholesterolemia, there are no reports of the molecular mechanism of its hypolipidemic effects. METHODS: We investigated the hypolipidemic effect of HVC1 in low-density lipoprotein receptor-deficient (LDLR(-/-)) mice fed a high-cholesterol diet for 13 weeks...
April 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28424256/dietary-patterns-and-type-2-diabetes-a-systematic-literature-review-and-meta-analysis-of-prospective-studies
#5
Franziska Jannasch, Janine Kröger, Matthias B Schulze
Background: Different methodologic approaches for constructing dietary patterns and differences in their composition limit conclusions on healthful patterns for diabetes prevention.Objective: We summarized evidence from prospective studies that examined associations of dietary patterns with type 2 diabetes by considering different methodologic approaches.Methods: The literature search (MEDLINE and Web of Science) identified prospective studies (cohorts or trials) that associated dietary patterns with diabetes incidence in nondiabetic and apparently healthy participants...
April 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28424183/biomarker-calibrated-nutrient-intake-and-healthy-diet-index-associations-with-mortality-risks-among-older-and-frail-women-from-the-women-s-health-initiative
#6
Oleg Zaslavsky, Shira Zelber-Sagi, James R Hebert, Susan E Steck, Nitin Shivappa, Fred K Tabung, Michael D Wirth, Yunqi Bu, James M Shikany, Tonya Orchard, Robert B Wallace, Linda Snetselaar, Lesley F Tinker
Background: Although studies to date have confirmed the association between nutrition and frailty, the impact of dietary intake and dietary patterns on survivorship in those with frailty is yet to be examined in a well-powered cohort with validated frailty status. Moreover, previous studies were limited by measurement error from dietary self-reports.Objective: We derived biomarker-calibrated dietary energy and protein intakes to address dietary self-report error. Using these data, we then evaluated the association of mortality in older women with frailty and dietary intake and healthy diet indexes, such as the alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH) score, and the Dietary Inflammatory Index (DII)...
April 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28422749/obesity-induced-hepatic-steatosis-is-mediated-by-endoplasmic-reticulum-stress-in-the-subfornical-organ-of-the-brain
#7
Julie A Horwath, Chansol Hurr, Scott D Butler, Mallikarjun Guruju, Martin D Cassell, Allyn L Mark, Robin L Davisson, Colin N Young
Nonalcoholic fatty liver disease (NAFLD), characterized by an excess accumulation of hepatic triglycerides, is a growing health epidemic. While ER stress in the liver has been implicated in the development of NAFLD, the role of brain ER stress - which is emerging as a key contributor to a number of chronic diseases including obesity - in NAFLD remains unclear. These studies reveal that chemical induction of ER stress in the brain caused hepatomegaly and hepatic steatosis in mice. Conversely, pharmacological reductions in brain ER stress in diet-induced obese mice rescued NAFLD independent of body weight, food intake, and adiposity...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28419227/neural-programmatic-role-of-leptin-tnf%C3%AE-melanocortin-and-glutamate-in-blood-pressure-regulation-versus-obesity-related-hypertension-in-male-c57bl-6-mice
#8
Bin Yu, Dongsheng Cai
Continuous nutritional surplus sets the stage for hypertension development. While moderate dietary obesity in mice is normotensive, the homeostatic balance is disrupted concurrent with an increased risk of hypertension, but it remains unclear how the obesity-associated pre-hypertensive state is converted into overt hypertension. Here, using mice with high-fat-diet (HFD) feeding-induced moderate obesity vs. control-diet (CD) feeding lean mice, we comparatively studied the effects of central leptin and TNFα as well as the involvement of the neuropeptide melanocortin pathway versus the neurotransmitter glutamate pathway...
April 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/28416368/nutritional-management-in-women-with-polycystic-ovary-syndrome-a-review-study
#9
REVIEW
Zeinab Faghfoori, Siavash Fazelian, Mahdi Shadnoush, Reza Goodarzi
Polycystic ovary syndrome (PCOS) is endocrine disorder in women of reproductive age, which leads to reproductive, hormonal and metabolic abnormalities. Due to the presence of insulin resistance, PCOS increases the risk of chronic diseases like type 2 diabetes, hypertension, lipid disorders, cardiovascular diseases and malignancies such as breast and endometrial cancer. The actual cause of this syndrome is unknown but environmental factors such as dietary habits play an important role in prevention and treatment and lifestyle modifications are the most important therapeutic strategies in these patients...
April 5, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28413966/the-clinical-problems-of-hypertension-treatment-in-hemodialysis-patients
#10
Charalampos N Loutradis, Costas Tsioufis, Pantelis A Sarafidis
Hypertension (HT) is present in >80% of patients undergoing haemodialysis (HD). Elevated blood pressure (BP) in hemodialysis patients is associated with cardiovascular events and mortality only when BP is recorded with home or ambulatory monitoring, since pre- and post-dialysis measurements are not valid estimates of BP levels during the inter-interval. Sodium and water overload is the most important of several mechanisms involved in HT development in HD. In this context, non-pharmacologic measures to ensure water and sodium balance by achieving patient dry weight and decreasing daily sodium intake, through modification of sodium level in the diet or in dialysis dialysate, are fundamental for HT control...
April 14, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28409833/dietary-salt-blunts-vasodilation-by-stimulating-epithelial-sodium-channels-in-endothelial-cells-from-salt-sensitive-rats
#11
Zi-Rui Wang, Hui-Bin Liu, Ying-Ying Sun, Qing-Qing Hu, Yu-Xia Li, Wei-Wan Zheng, Chang-Jiang Yu, Xin-Yuan Li, Ming-Ming Wu, Bin-Lin Song, Jian-Jun Mu, Zu-Yi Yuan, Zhi-Ren Zhang, He-Ping Ma
BACKGROUND AND PURPOSE: Our recent studies show that the reduced activity of epithelial sodium channels (ENaC) in endothelial cells accounts for the adaptation of vasculature to salt in Sprague-Dawley (SD) rats. The present study examines a hypothesis that enhanced ENaC activity mediates the loss of vasorelaxation in Dahl salt-sensitive (SS) rats. EXPERIMENTAL APPROACH: We used the cell-attached patch-clamp technique to record ENaC activity in split-open mesenteric arteries...
April 13, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28408634/moderate-20-fructose-enriched-diet-stimulates-salt-sensitive-hypertension-with-increased-salt-retention-and-decreased-renal-nitric-oxide
#12
Kevin L Gordish, Kamal M Kassem, Pablo A Ortiz, William H Beierwaltes
Previously, we reported that 20% fructose diet causes salt-sensitive hypertension. In this study, we hypothesized that a high salt diet supplemented with 20% fructose (in drinking water) stimulates salt-sensitive hypertension by increasing salt retention through decreasing renal nitric oxide. Rats in metabolic cages consumed normal rat chow for 5 days (baseline), then either: (1) normal salt for 2 weeks, (2) 20% fructose in drinking water for 2 weeks, (3) 20% fructose for 1 week, then fructose + high salt (4% NaCl) for 1 week, (4) normal chow for 1 week, then high salt for 1 week, (5) 20% glucose for 1 week, then glucose + high salt for 1 week...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28406707/moringa-oleifera-rich-diet-and-t-cell-calcium-signaling-in-hypertensive-rats
#13
E S Attakpa, N W Chabi, G A Bertin, J-M Ategbo, B Seri, N A Khan
Moringa oleifera is a plant whose fruits, roots and leaves have been advocated for traditional medicinal uses. The physico-chemical analysis shows that, Moringa contains more dietary polyunsaturated fatty acids (PUFA) than saturated fatty acids (SFA). The consumption of an experimental diet enriched with Moringa oleifera extracts lowered blood pressure in spontaneously hypertensive rats (SHR), but not in normotensive Wistar-Kyoto (WKY) rats as compared to rats fed an unsupplemented control diet. Anti-CD3-stimulated T-cell proliferation was diminished in both strains of rats fed the Moringa oleifera...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28405988/a-study-of-salt-and-fat-consumption-pattern-in-regional-indian-diet-among-hypertensive-and-dyslipidemic-patients-script-study
#14
Dayanand Kumbla, Mala Dharmalingam, Kalpesh Dalvi, Saumitra Ray, Mahesh K Shah, Sanjay Gupta, S Sadhanandham, A K Ajmani, Sanjay Nag, Srinivas Murthy, Mohana Murugan, Abhijit Trailokya, Tushar Fegade
BACKGROUND: Cardiovascular diseases are leading cause of mortality and morbidity. There is an increasing prevalence of hypertension and dyslipidemia due to globalization and adoption of westernized dietary habits in India. These transitions are manifest in dietary patterns and health outcomes. OBJECTIVE: To study the dietary salt and fat intake among patients diagnosed with hypertension and dyslipidemia in India. METHODS: SCRIPT study was a pilot exploratory, cross-sectional, observational, descriptive, multi-center study...
December 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28405625/resistance-to-hypertension-mediated-by-intercalated-cells-of-the-collecting-duct
#15
Johannes Stegbauer, Daian Chen, Marcela Herrera, Matthew A Sparks, Ting Yang, Eva Königshausen, Susan B Gurley, Thomas M Coffman
The renal collecting duct (CD), as the terminal segment of the nephron, is responsible for the final adjustments to the amount of sodium excreted in urine. While angiotensin II modulates reabsorptive functions of the CD, the contribution of these actions to physiological homeostasis is not clear. To examine this question, we generated mice with cell-specific deletion of AT1A receptors from the CD. Elimination of AT1A receptors from both principal and intercalated cells (CDKO mice) had no effect on blood pressures at baseline or during successive feeding of low- or high-salt diets...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28405001/dietary-factors-in-rheumatic-autoimmune-diseases-a-recipe-for-therapy
#16
REVIEW
Shani Dahan, Yahel Segal, Yehuda Shoenfeld
Today, we are facing a new era of digitization in the health care system, and with increased access to health care information has come a growing demand for safe, cost-effective and easy to administer therapies. Dietary habits have a crucial influence on human health, affecting an individual's risk for hypertension, heart disease and stroke, as well as influencing the risk of developing of cancer. Moreover, an individual's lifestyle choices can greatly influence the progression and manifestation of chronic autoimmune rheumatic diseases...
April 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28404738/microbiotal-host-interactions-and-hypertension
#17
REVIEW
Sarah Galla, Saroj Chakraborty, Blair Mell, Matam Vijay-Kumar, Bina Joe
Hypertension, or elevated blood pressure (BP), has been extensively researched over decades and clearly demonstrated to be caused due to a combination of host genetic and environmental factors. Although much research remains to be conducted to pin-point the precise genetic elements on the host genome that control BP, new lines of evidence are emerging to indicate that, besides the host genome, the genomes of all indigenous commensal micro-organisms, collectively referred to as the microbial metagenome or microbiome, are important, but largely understudied, determinants of BP...
May 2017: Physiology
https://www.readbyqxmd.com/read/28404591/intravital-imaging-of-the-kidney-in-a-rat-model-of-salt-sensitive-hypertension
#18
Bradley T Endres, Ruben M Sandoval, George J Rhodes, Silvia B Campos-Bilderback, Malgorzata M Kamocka, Christopher McDermott-Roe, Alexander Staruschenko, Bruce A Molitoris, Aron M Geurts, Oleg Palygin
Hypertension is one of the most prevalent diseases worldwide, and a major risk factor for renal failure and cardiovascular disease. The role of albuminuria, a common feature of hypertension and robust predictor of cardiorenal disorders, remains incompletely understood. The goal of this study was to investigate the mechanisms leading to albuminuria in the kidney of a rat model of hypertension, the Dahl salt-sensitive (SS) rat. To determine the relative contributions of the glomerulus and proximal tubule (PT) to albuminuria, we applied intravital two-photon-based imaging to investigate the complex renal physiological changes that occur during salt-induced hypertension...
April 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28403155/fruit-consumption-and-physical-activity-in-relation-to-all-cause-and-cardiovascular-mortality-among-70-000-chinese-adults-with-pre-existing-vascular-disease
#19
Xiaocao Tian, Huaidong Du, Liming Li, Derrick Bennett, Ruqin Gao, Shanpeng Li, Shaojie Wang, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Junshi Chen, Yan Gao, Min Weng, Zengchang Pang, Baofa Jiang, Zhengming Chen
OBJECTIVES: To assess the associations of fresh fruit consumption and total physical activity with all-cause and cardiovascular mortality among Chinese adults who have been diagnosed with cardiovascular disease (CVD) or hypertension. METHODS: During 2004-08, the China Kadoorie Biobank study recruited 70,047 adults, aged 30-79 years, with physician-diagnosed stroke or transient ischaemic attack, ischemic heart disease, or hypertension. Information on diet and physical activity was collected using an interviewer-administered electronic questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28402430/st-segment-depression-on-24-hour-electrocardiography-predicts-incident-atrial-fibrillation-in-two-population-based-cohorts
#20
Linda S B Johnson, John Berntsson, Tord Juhlin, Jeff S Healey, Steen Juul-Möller, Per Wollmer, Peter M Nilsson, Bo Hedblad, Mårten Rosenqvist, Gunnar Engström
Aims: ST-depression at 24hECG has not been studied in relation to atrial fibrillation (AF) risk. We aimed to determine whether ST-depression at 24hECG was associated with incident AF in two Swedish population-based cohorts - a sub-cohort of the Malmö Diet and Cancer study (MDCS), and the cohort 'Men born in 1914', and to determine whether 24hECG could be used to predict AF development. Methods and results: There were 378 acceptable 24hECG recordings in the MDCS (mean age 64...
April 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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