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https://www.readbyqxmd.com/read/28721209/recent-advances-in-preventing-stroke-recurrence
#1
REVIEW
J David Spence
Recent advances in secondary stroke prevention include new evidence in hypertension, nutrition, anticoagulation, antiplatelet therapy, intracranial stenosis, percutaneous closure of patent foramen ovale, and lipid-lowering therapy. Individualized therapy for hypertension based on phenotyping with plasma renin and aldosterone markedly improves blood pressure control in patients with resistant hypertension. A Mediterranean diet can reduce the risk of stroke by nearly half. The diagnosis and treatment of metabolic vitamin B12 deficiency, and B vitamins to lower homocysteine, can reduce the risk of stroke by approximately 30%...
2017: F1000Research
https://www.readbyqxmd.com/read/28721063/annual-deterioration-of-renal-function-in-hypertensive-patients-with-and-without-diabetes
#2
Jorge Polonia, André Azevedo, Miguel Monte, José A Silva, Susana Bertoquini
BACKGROUND: Chronic kidney disease (CKD) complicates hypertension and diabetes. Knowledge of the deterioration rate of CKD may anticipate adjustment of therapies with renal elimination. This study evaluates the rate of annual deterioration of renal function in hypertensive patients either with type 2 diabetes (DM2) or without it (non-DM) followed for 5 years and relates it with blood pressure (BP) and glycemic control. MATERIALS AND METHODS: Out of a total of 1924 patients, 1023 patients (594 non-DM and 429 DM2, 53% female, aged 62...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28720883/chronic-high-sodium-diet-intake-after-weaning-lead-to-neurogenic-hypertension-in-adult-wistar-rats
#3
Paula Magalhães Gomes, Renato Willian Martins Sá, Giovana Lopes Aguiar, Milede Hanner Saraiva Paes, Andréia Carvalho Alzamora, Wanderson Geraldo Lima, Lisandra Brandino de Oliveira, Sean David Stocker, Vagner Roberto Antunes, Leonardo M Cardoso
In this study, we investigated some mechanisms involved in sodium-dependent hypertension of rats exposed to chronic salt (NaCl) intake from weaning until adult age. Weaned male Wistar rats were placed under high (0.90% w/w, HS) or regular (0.27% w/w, Cont) sodium diets for 12 weeks. Water consumption, urine output and sodium excretion were higher in HS rats compared to control. Blood pressure (BP) was directly measured by the arterial catheter and found 13.8% higher in HS vs Cont rats. Ganglionic blockade with hexamethonium caused greater fall in the BP of HS rats (33%), and central antagonism of AT1 receptors (losartan) microinjected into the lateral ventricle reduced BP level of HS, but not of Cont group...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720877/role-of-the-histone-deacetylase-inhibitor-valproic-acid-in-high-fat-diet-induced-hypertension-via-inhibition-of-hdac1-angiotensin-ii-axis
#4
J Choi, S Y Park, T K Kwon, S-I Sohn, K M Park, J I Kim
BACKGROUND: Obesity is known as an epidemic worldwide because of consumption of westernized high-fat diets and one of the major risk factors of hypertension. Histone deacetylases (HDACs) control gene expression by regulating histone/non-histone protein deacetylation. HDAC inhibitors exert anti-cancer and anti-inflammatory effects and play a protective role in cardiovascular diseases. In the present study, we tested the effect of an FDA-approved pan-HDAC inhibitor valproic acid (VPA) on high-fat diet (HFD)-induced hypertension in mice...
July 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28719636/the-non-diuretic-hypotensive-effects-of-thiazides-are-enhanced-during-volume-depletion-states
#5
Saeed Alshahrani, Robert M Rapoport, Kamyar Zahedi, Min Jiang, Michelle Nieman, Sharon Barone, Andrea L Meredith, John N Lorenz, Jack Rubinstein, Manoocher Soleimani
Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC). However, chronic volume depletion and diuresis are minimal while lowered blood pressure (BP) is maintained on thiazides. Thus, a vasodilator action of thiazides is proposed, likely via Ca2+-activated K+ (BK) channels in vascular smooth muscles. This study ascertains the role of volume depletion induced by salt restriction or salt wasting in NCC KO mice on the non-diuretic hypotensive action of HCTZ...
2017: PloS One
https://www.readbyqxmd.com/read/28716988/blood-pressure-lowering-and-safety-improvements-with-liver-angiotensinogen-inhibition-in-models-of-hypertension-and-kidney-injury
#6
Adam E Mullick, Steve T Yeh, Mark J Graham, Jeffery A Engelhardt, Thazha P Prakash, Rosanne M Crooke
Uncontrolled hypertension is an important contributor to cardiovascular disease. Despite the armamentarium of antihypertensive treatments, there remains a need for novel agents effective in individuals who cannot reach acceptable blood pressure levels. Inhibitors targeting the renin-angiotensin-aldosterone system (RAAS) are widely used but may not optimally inhibit RAAS and demonstrate an acceptable safety profile. Experiments were conducted to characterize a series of AGT (angiotensinogen) antisense oligonucleotides (ASOs) and compare their efficacy and tolerability to traditional RAAS blockade...
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28715555/application-of-a-lifestyle-based-tool-to-estimate-premature-cardiovascular-disease-events-in-young-adults-the-coronary-artery-risk-development-in-young-adults-cardia-study
#7
Holly C Gooding, Hongyan Ning, Matthew W Gillman, Christina Shay, Norrina Allen, David C Goff, Donald Lloyd-Jones, Stephanie Chiuve
Importance: Few tools exist for assessing the risk for early atherosclerotic cardiovascular disease (ASCVD) events in young adults. Objective: To assess the performance of the Healthy Heart Score (HHS), a lifestyle-based tool that estimates ASCVD events in older adults, for ASCVD events occurring before 55 years of age. Design, Setting, and Participants: This prospective cohort study included 4893 US adults aged 18 to 30 years from the Coronary Artery Risk Development in Young Adults (CARDIA) study...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28713910/anti-obesity-effects-of-yellow-catfish-protein-hydrolysate-on-mice-fed-a-45-kcal-high-fat-diet
#8
Mi-Ryung Kim, Joo-Wan Kim, Jeong Been Park, Yong-Ki Hong, Sae Kwang Ku, Jae-Suk Choi
Obesity contributes to the etiologies of a variety of comorbid conditions, such as type 2 diabetes, hypertension and cardiovascular disease. In the present study, the anti-obesity effects of yellow catfish protein hydrolysate (YPh) were observed in mice fed a 45% kcal high-fat diet (HFD) compared with those of mice treated with simvastatin. The HFD-fed control mice exhibited noticeable increase in body weight, and whole-body and abdominal fat densities, periovarian and abdominal wall-deposited fat pad weight, as well as in the levels of triglycerides (TG), blood total cholesterol (TC), low-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea nitrogen, and in the fecal TG and TC contents...
July 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28713487/moringa-oleifera-seeds-attenuate-vascular-oxidative-and-nitrosative-stresses-in-spontaneously-hypertensive-rats
#9
Joseph Iharinjaka Randriamboavonjy, Marc Rio, Pierre Pacaud, Gervaise Loirand, Angela Tesse
Moringa oleifera (MOI) is a tree currently used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including arterial hypertension. We previously described a cardiac protective role of a treatment with MOI seeds in spontaneously hypertensive rats (SHR). Here, we investigated the effects of this treatment on oxidative and nitrosative vascular stresses in SHR, with normotensive Wistar Kyoto rats used as controls. Oxidative and nitrosative stresses detected in SHR aortas using the fluorescent dye dihydroethidine and protein nitrotyrosine staining were reduced in MOI-treated SHR aortas...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28712161/a-health-behavior-score-is-associated-with-hypertension-and-obesity-among-australian-adults
#10
Katherine M Livingstone, Sarah A McNaughton
OBJECTIVE: To investigate associations between a health behavior score and prevalence of hypertension and overweight/obesity. METHODS: Adults (n = 4,609; 19-85 years) were included from the cross-sectional Australian National Nutrition and Physical Activity Survey. A health behavior score was derived based on individuals meeting recommendations for diet quality, smoking, physical activity, sedentary time, and sleep. Poisson regression estimated the prevalence ratio (PR) of hypertension and overweight/obesity by health behavior score...
July 16, 2017: Obesity
https://www.readbyqxmd.com/read/28710353/potential-mediating-biomarkers-underlying-the-association-of-body-mass-index-or-waist-circumference-with-blood-pressure-results-from-three-population-based-studies
#11
Xiaoyan Wu, Xue Yang, Ruiqi Shan, Tianjiao Li, Tianqi Zi, Ying Li, Lixin Na, Changhao Sun
We conducted a comprehensive and in-depth assessment of body mass index (BMI) or waist circumference (WC) related to blood pressure (BP) and determined whether the association is mediated by the possible potential mediators in the cross-sectional survey of the Harbin Cohort Study on Diet, Nutrition and Chronic Non-communicable Diseases of 7094 participants aged 20-74 years, and validated the significant findings in the US National Health and Nutrition Examination Survey four cross-sectional cohorts (2005-2006, 2007-2008, 2009-2010, and 2011-2012) and the cohort data of the Harbin People's Health Study (a median of 4...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709772/physical-health-promotion-in-patients-with-functional-psychoses-receiving-community-psychiatric-services-results-of-the-physico-dsm-vr-study
#12
Elena Bonfioli, Maria Angela Mazzi, Loretta Berti, Lorenzo Burti
OBJECTIVES: Psychotic patients have poorer health behaviours, including poor diets and sedentary lifestyles increasing their risk for obesity, diabetes, hypertension, and dyslipidaemia, and tend to have a shorter life expectancy as compared to nonpsychiatric populations. Lifestyle intervention programmes that target modifiable risk factors in such patients have produced uneven results. The objective was to evaluate the efficacy of a package of health promotion strategies to improve diet and physical exercise in psychotic patients...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28705075/higher-adherence-to-the-mediterranean-diet-is-inversely-associated-with-having-hypertension-is-low-salt-intake-a-mediating-factor
#13
Melania La Verde, Serena Mulè, Gaetano Zappalà, Gaetano Privitera, Giuseppe Maugeri, Francesco Pecora, Marina Marranzano
Blood pressure (BP) is a major risk factor for population health worldwide and a preventable disease through lifestyle modification. The aim of this study was to assess the association between adherence to the Mediterranean diet (MD) and occurrence of hypertension in a Mediterranean cohort. Demographic and dietary data of 1937 adults were collected in 2014-2015 from the general population of Catania, Sicily (Italy). Food frequency questionnaires and a MD adherence score were used to assess exposure variables...
July 14, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28701338/lifestyle-in-progression-from-hypertensive-disorders-of-pregnancy-to-chronic-hypertension-in-nurses-health-study-ii-observational-cohort-study
#14
Simon Timpka, Jennifer J Stuart, Lauren J Tanz, Eric B Rimm, Paul W Franks, Janet W Rich-Edwards
Objectives To study the association between lifestyle risk factors and chronic hypertension by history of hypertensive disorders of pregnancy (HDP: gestational hypertension and pre-eclampsia) and investigate the extent to which these risk factors modify the association between HDP and chronic hypertension.Design Prospective cohort study.Setting Nurses' Health Study II (1991-2013).Participants 54 588 parous women aged 32 to 59 years with data on reproductive history and without previous chronic hypertension, stroke, or myocardial infarction...
July 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28701323/renal-denervation-attenuates-hypertension-but-not-salt-sensitivity-in-etb-receptor-deficient-rats
#15
Bryan K Becker, Amanda C Feagans, Daian Chen, Malgorzata Kasztan, Chunhua Jin, Joshua S Speed, Jennifer S Pollock, David M Pollock
Hypertension is a prevalent pathology that increases risk for numerous cardiovascular diseases. Because the etiology of hypertension varies across patients, specific and effective therapeutic approaches are needed. The role of renal sympathetic nerves is established in numerous forms of hypertension, but their contribution to salt-sensitivity and interaction with factors such as endothelin-1 are poorly understood. Rats deficient of functional ETB receptors (ETB-def) on all tissues except sympathetic nerves are hypertensive and exhibit salt-sensitive increases in blood pressure...
July 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28700845/association-of-changes-in-diet-quality-with-total-and-cause-specific-mortality
#16
Mercedes Sotos-Prieto, Shilpa N Bhupathiraju, Josiemer Mattei, Teresa T Fung, Yanping Li, An Pan, Walter C Willett, Eric B Rimm, Frank B Hu
BACKGROUND: Few studies have evaluated the relationship between changes in diet quality over time and the risk of death. METHODS: We used Cox proportional-hazards models to calculate adjusted hazard ratios for total and cause-specific mortality among 47,994 women in the Nurses' Health Study and 25,745 men in the Health Professionals Follow-up Study from 1998 through 2010. Changes in diet quality over the preceding 12 years (1986-1998) were assessed with the use of the Alternate Healthy Eating Index-2010 score, the Alternate Mediterranean Diet score, and the Dietary Approaches to Stop Hypertension (DASH) diet score...
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28700686/renin-inhibition-improves-metabolic-syndrome-and-reduces-angiotensin-ii-levels-and-oxidative-stress-in-visceral-fat-tissues-in-fructose-fed-rats
#17
Chu-Lin Chou, Heng Lin, Jin-Shuen Chen, Te-Chao Fang
Renin-angiotensin system in visceral fat plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats. However, the effects of renin inhibition on visceral adiposity in metabolic syndrome are not fully investigated. We investigated the effects of renin inhibition on visceral adiposity in fructose-fed rats. Male Wistar-Kyoto rats were divided into 4 groups for 8-week experiments: Group Con (standard chow diet), Group Fru (high-fructose diet; 60% fructose), Group FruA (high-fructose diet and concurrent aliskiren treatment; 100 mg/kg body weight [BW] per day), and Group FruB (high-fructose diet and subsequent, i...
2017: PloS One
https://www.readbyqxmd.com/read/28697569/relationships-of-dietary-patterns-foods-and-micro-and-macronutrients-with-alzheimer-s-disease-and-late-life-cognitive-disorders-a-systematic-review
#18
Vincenzo Solfrizzi, Carlo Custodero, Madia Lozupone, Bruno P Imbimbo, Vincenzo Valiani, Pasquale Agosti, Andrea Schilardi, Alessia D'Introno, Maddalena La Montagna, Mariapaola Calvani, Vito Guerra, Rodolfo Sardone, Daniela I Abbrescia, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Giancarlo Logroscino, Carlo Sabbá, Francesco Panza
In the last decade, the association between diet and cognitive function or dementia has been largely investigated. In the present article, we systematically reviewed observational studies published in the last three years (2014-2016) on the relationship among dietary factors and late-life cognitive disorders at different levels of investigation (i.e., dietary patterns, foods and food-groups, and dietary micro- and macronutrients), and possible underlying mechanisms of the proposed associations. From the reviewed evidence, the National Institute on Aging-Alzheimer's Association guidelines for Alzheimer's disease (AD) and cognitive decline due to AD pathology introduced some evidence suggesting a direct relation between diet and changes in the brain structure and activity...
July 5, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28697260/behavioral-counseling-to-promote-a-healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-without-cardiovascular-risk-factors-us-preventive-services-task-force-recommendation-statement
#19
David C Grossman, Kirsten Bibbins-Domingo, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Adults who adhere to national guidelines for a healthful diet and physical activity have lower rates of cardiovascular morbidity and mortality than those who do not. All persons, regardless of their risk status for cardiovascular disease (CVD), can gain health benefits from healthy eating behaviors and appropriate physical activity. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on behavioral counseling to promote a healthful diet and physical activity for cardiovascular disease prevention among adults without obesity who do not have cardiovascular risk factors (hypertension, dyslipidemia, abnormal blood glucose levels, or diabetes)...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28697259/behavioral-counseling-to-promote-a-healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-without-known-cardiovascular-disease-risk-factors-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#20
REVIEW
Carrie D Patnode, Corrine V Evans, Caitlyn A Senger, Nadia Redmond, Jennifer S Lin
Importance: Unhealthful dietary patterns, low levels of physical activity, and high sedentary time increase the risk of cardiovascular disease. Objective: To systematically review the evidence on the benefits and harms of behavioral counseling for the primary prevention of cardiovascular disease in adults without known cardiovascular risk factors to inform the US Preventive Services Task Force. Data Sources: MEDLINE, PubMed, Cochrane Central Register of Controlled Trials, and PsycINFO for studies published in the English language between January 1, 2013, and May 25, 2016, and ongoing surveillance in targeted publications through March 24, 2017...
July 11, 2017: JAMA: the Journal of the American Medical Association
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