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https://www.readbyqxmd.com/read/29137612/comparison-of-semi-quantitative-and-quantitative-dynamic-contrast-enhanced-mri-evaluations-of-vertebral-marrow-perfusion-in-a-rat-osteoporosis-model
#1
Jingqi Zhu, Zuogang Xiong, Jiulong Zhang, Yuyou Qiu, Ting Hua, Guangyu Tang
BACKGROUND: This study aims to investigate the technical feasibility of semi-quantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the assessment of longitudinal changes of marrow perfusion in a rat osteoporosis model, using bone mineral density (BMD) measured by micro-computed tomography (micro-CT) and histopathology as the gold standards. METHODS: Fifty rats were randomly assigned to the control group (n=25) and ovariectomy (OVX) group whose bilateral ovaries were excised (n=25)...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29135409/double-inlay-plus-ventral-onlay-buccal-mucosa-graft-for-simultaneous-penile-and-bulbar-urethral-stricture
#2
Luciano A Favorito, Paulo P Conte, Ulisses G Sobrinho, Rodrigo G Martins, Tomas Accioly
OBJECTIVES: Buccal mucosa grafts and fascio-cutaneous flaps are frequently used in long anterior urethral strictures (1). The inlay and onlay buccal mucosa grafts are easier to perform, do not need urethral mobilization and generally have good long-term results (2-4). In the present video, we present a case where we used a double buccal mucosa graft technique in a simultaneous penile and bulbar urethral stricture. MATERIALS AND METHODS: A 54 year-old male patient was submitted to appendectomy where a urethral catheter was used for two days in May 2015...
November 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29135009/bacterial-species-identifiable-magnetic-nanosystems-for-early-sepsis-diagnosis-and-extracorporeal-photodynamic-blood-disinfection
#3
Jianhao Wang, Hao Wu, Yanmei Yang, Rong Yan, Yuan Zhao, Yanhao Wang, Aihong Chen, Shilong Shao, Pengju Jiang, Yong-Qiang Li
Despite the numerous bacteria detection and elimination techniques available nowadays, sensitive diagnosis and treatment of sepsis (caused by the presence of bacteria in the bloodstream), especially at the early stage, remain big challenges. Here we report a nanosystem for early sepsis diagnosis and complete extracorporeal blood disinfection, based on iron oxide magnetic nanoparticles functionalized with chlorin e6 molecules and bacterial species-identifiable aptamers (Fe3O4-Ce6-Apt). We demonstrate that the Fe3O4-Ce6-Apt nanosystem can achieve simultaneous blood bacterial species identification and enrichment in a single step, and the enriched bacteria can be easily detected with the assistance of fluorescence microscopic determination...
November 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29131927/direct-evidence-for-the-origin-of-bis-gold-intermediates-probing-gold-catalysis-with-mass-spectrometry
#4
Mei Lu, Yijin Su, Pengyi Zhao, Xiaohan Ye, Yi Cai, Xiaodong Shi, Eric Masson, Fengyao Li, J Larry Campbell, Hao Chen
Gold-catalyzed alkyne hydration was studied using in-situ reacting mass spectrometry (MS) technology. By monitoring the reaction process in solution under different conditions (regular and very diluted catalyst concentrations, different pHs) and examining the reaction occurrence in the early reaction stage (1-2 ms after mixing) with MS, we collected a series of experimental evidence to support that the bisgold complex is a key reaction intermediate. Furthermore, both experimental and computational studies confirmed that the σ,π-bisgold complexes are not active intermediate toward nucleophilic addition...
November 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29131400/evaluation-of-3-serological-tests-for-early-detection-of-leptospira-specific-antibodies-in-experimentally-infected-dogs
#5
J Lizer, S Velineni, A Weber, M Krecic, P Meeus
BACKGROUND: Leptospirosis in dogs is a disease of global importance. Early detection and appropriate therapeutic intervention are necessary to resolve infection and prevent zoonotic transmission. However, its diagnosis is hindered by nonspecific clinical signs and lack of rapid diagnostic tests of early infection. Recently, 2 rapid point-of-care tests (WITNESS Lepto [WITNESS Lepto, Zoetis LLC, Kalamazoo, MI, USA] and SNAP Lepto [SNAP Lepto, IDEXX Laboratories, Westbrook, ME, USA]) for detection of Leptospira-specific antibodies in canine sera were developed...
November 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29128041/intraperitoneal-urinary-bladder-perforation-with-pneumoperitoneum-in-association-with-indwelling-foley-catheter-diagnosed-in-emergency-department
#6
Chenyang Zhan, Pedro P Maria, R Joshua Dym
BACKGROUND: Indwelling Foley catheter is a rare cause of urinary bladder perforation, a serious injury with high mortality that demands accurate and prompt diagnosis. While the gold standard for diagnosis of bladder injury is computed tomography (CT) cystography, few bladder ruptures associated with Foley catheter have been reported to be diagnosed in the emergency department (ED). CASE REPORT: An 83-year-old man with indwelling Foley catheter presented to the ED for hematuria and altered mental status...
November 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29126059/enhancing-early-psychosis-treatment-using-smartphone-technology-a-longitudinal-feasibility-and-validity-study
#7
Tara A Niendam, Laura M Tully, Ana-Maria Iosif, Divya Kumar, Kathleen E Nye, Jennifer C Denton, Lauren N Zakskorn, Taylor L Fedechko, Katherine M Pierce
Smartphone applications that promote symptom tracking and self-management may improve treatment of serious mental illness (SMI). Although feasibility has been established in chronic adult outpatient or inpatient SMI samples, no data exist regarding implementation of smartphone technology in adolescent and young adult populations as part of early psychosis (EP) outpatient care. We implemented a smartphone "app" plus clinician Dashboard as an add-on treatment tool in the University of California, Davis Early Psychosis Program...
October 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29124936/in-vivo-ct-photoacoustic-imaging-and-nir-triggered-chemo-photothermal-combined-therapy-based-on-a-gold-nanostar-mesoporous-silica-and-thermo-sensitive-liposomes-composited-nanoprobe
#8
Jie An, Xiao-Quan Yang, Kai Cheng, Xian-Lin Song, Lin Zhang, Cheng Li, Xiao-Shuai Zhang, Yang Xuan, Yuan-Yang Song, Bi-Yun Fang, Xiao-Lin Hou, Yuan-Di Zhao, Bo Liu
Safe multifunctional nanoplatforms that have multiple therapeutic functions integrated with imaging capabilities are highly desired for biomedical applications. In this paper, targeted chemo-photothermal synergistic therapy and photoacoustic/CT imaging of tumor were achieved by one novel multifunctional nanoprobe (GMS/DOX@SLB-FA), it was composed of gold nanostar core and doxorubicin (DOX) loading mesoporous silica shell (GMS), which was coated with folic acid (FA) modified thermosensitively supported lipid bilayer (FA-SLB) as gatekeeper...
November 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29124760/indications-and-methodology-for-video-electroencephalographic-studies-in-the-epilepsy-monitoring-unit
#9
Jerry J Shih, Nathan B Fountain, Susan T Herman, Anto Bagic, Fred Lado, Susan Arnold, Mary L Zupanc, Ellen Riker, David M Labiner
Although the epilepsy and neurology communities have position papers on a number of topics pertaining to epilepsy diagnosis and management, no current paper exists for the rationale and appropriate indications for epilepsy monitoring unit (EMU) evaluation. General neurologists, hospital administrators, and insurers also have yet to fully understand the role this type of testing has in the diagnosis and management of individuals with paroxysmal neurologic symptoms. This review outlines the indications for long-term video-electroencephalography (VEEG) for typical elective admissions to a specialized inpatient setting...
November 10, 2017: Epilepsia
https://www.readbyqxmd.com/read/29124056/microbial-therapeutics-designed-for-infant-health
#10
REVIEW
Claire Watkins, Catherine Stanton, C Anthony Ryan, R Paul Ross
Acknowledgment of the gut microbiome as a vital asset to health has led to multiple studies attempting to elucidate its mechanisms of action. During the first year of life, many factors can cause fluctuation in the developing gut microbiome. Host genetics, maternal health status, mode of delivery, gestational age, feeding regime, and perinatal antibiotic usage, are known factors which can influence the development of the infant gut microbiome. Thus, the microbiome of vaginally born, exclusively breastfed infants at term, with no previous exposure to antibiotics, either directly or indirectly from the mother, is to be considered the "gold standard...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29122469/sensitivity-of-whole-exome-sequencing-in-detecting-infantile-and-late-onset-pompe-disease
#11
Mari Mori, Gloria Haskell, Zoheb Kazi, Xiaolin Zhu, Stephanie M DeArmey, Jennifer L Goldstein, Deeksha Bali, Catherine Rehder, Elizabeth T Cirulli, Priya S Kishnani
Pompe disease is a metabolic myopathy with a wide spectrum of clinical presentation. The gold-standard diagnostic test is acid alpha-glucosidase assay on skin fibroblasts, muscle or blood. Identification of two GAA pathogenic variants in-trans is confirmatory. Optimal effectiveness of enzyme replacement therapy hinges on early diagnosis, which is challenging in late-onset form of the disease due to non-specific presentation. Next-generation sequencing-based panels effectively facilitate diagnosis, but the sensitivity of whole-exome sequencing (WES) in detecting pathogenic GAA variants remains unknown...
October 17, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29121597/rapid-synthesis-of-125-i-integrated-gold-nanoparticles-for-use-in-combined-neoplasm-imaging-and-targeted-radionuclide-therapy
#12
Ryan Clanton, Arnulfo Gonzalez, Sriram Shankar, Gamal Akabani
The selective delivery of radionuclides to tissues of interest remains a problematic task during treatment. The lack of tissue specificity for many therapeutics limit their efficacy by putting healthy organs and tissues at risk (e.g., side effects). Therefore, high specificity therapeutic strategies are needed to overcome these risks. The objective of this study was to use a modified citrate reduction technique to synthesize gold nanoparticles (AuNPs) containing (125)I in order to combine their unique therapeutic and diagnostic properties...
November 6, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29119262/role-of-cardiac-pet-in-clinical-practice
#13
REVIEW
Brian M Salata, Parmanand Singh
Early identification of atherosclerosis and at-risk lesions plays a critical role in reducing the burden of cardiovascular disease. While invasive coronary angiography serves as the gold standard for diagnosing coronary artery disease, non-invasive imaging techniques provide visualization of both anatomical and functional atherosclerotic processes prior to clinical presentation. The development of cardiac positron emission tomography (PET) has greatly enhanced our capability to diagnose and treat patients with early stages of atherosclerosis...
November 9, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29118554/risk-factors-for-postoperative-recurrence-of-crohn-s-disease-with-emphasis-on-surgical-predictors
#14
REVIEW
Antonios Gklavas, Dionysios Dellaportas, Ioannis Papaconstantinou
Intestinal resection for Crohn's disease is not curative and postoperative recurrence rates remain high. Early detection of indices associated with recurrence and risk stratification are fundamental for the postoperative management of patients. Early endoscopy at 6-12 months is the "gold standard" procedure, whereas other modalities such as fecal calprotectin and imaging techniques can contribute to the diagnosis of recurrence. The purpose of this review is to summarize current data regarding risk factors correlated with postoperative relapse...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29118096/the-sgc-beyond-structural-genomics-redefining-the-role-of-3d-structures-by-coupling-genomic-stratification-with-fragment-based-discovery
#15
REVIEW
Anthony R Bradley, Aude Echalier, Michael Fairhead, Claire Strain-Damerell, Paul Brennan, Alex N Bullock, Nicola A Burgess-Brown, Elisabeth P Carpenter, Opher Gileadi, Brian D Marsden, Wen Hwa Lee, Wyatt Yue, Chas Bountra, Frank von Delft
The ongoing explosion in genomics data has long since outpaced the capacity of conventional biochemical methodology to verify the large number of hypotheses that emerge from the analysis of such data. In contrast, it is still a gold-standard for early phenotypic validation towards small-molecule drug discovery to use probe molecules (or tool compounds), notwithstanding the difficulty and cost of generating them. Rational structure-based approaches to ligand discovery have long promised the efficiencies needed to close this divergence; in practice, however, this promise remains largely unfulfilled, for a host of well-rehearsed reasons and despite the huge technical advances spearheaded by the structural genomics initiatives of the noughties...
November 8, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/29116975/progress-on-a-new-kind-of-progress-test-assessing-medical-students-clinical-skills
#16
Robin H DeMuth, Jonathan G Gold, Brian E Mavis, Dianne P Wagner
PROBLEM: Progress testing of medical knowledge has advantages over traditional medical school examination strategies. However, little is known about its use in assessing medical students' clinical skills or their integration of clinical skills with necessary science knowledge. The authors previously reported on the feasibility of the Progress Clinical Skills Examination (PCSE), piloted with a group of early learners. This subsequent pilot test studied the exam's validity to determine whether the PCSE is sensitive to the growth in students' clinical skills across the four years of medical school...
November 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29115991/evaluation-of-the-deki-reader%C3%A2-an-automated-rdt-reader-and-data-management-device-in-a-household-survey-setting-in-low-malaria-endemic-southwestern-uganda
#17
Caesar Oyet, Michelle E Roh, Gertrude N Kiwanuka, Patrick Orikiriza, Martina Wade, Sunil Parikh, Juliet Mwanga-Amumpaire, Yap Boum
BACKGROUND: Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective malaria control tool used in many resource-constrained settings. However, poor quality control and quality assurance hinder the accurate reporting of malaria diagnoses. Recent use of a portable, battery operated RDT reader (Deki Reader™, Fio Corporation) has shown to have high agreement with visual inspection across diverse health centre settings, however evidence of its feasibility and usability during cross sectional surveys are limited...
November 7, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29115484/lipoic-acid-alleviates-l%C3%A2-dopa%C3%A2-induced-dyskinesia-in-6%C3%A2-ohda-parkinsonian-rats-via-anti%C3%A2-oxidative-stress
#18
Su-Fang Zhang, Cheng-Long Xie, Jing-Ya Lin, Mei-Hua Wang, Xi-Jin Wang, Zhen-Guo Liu
Levodopa (L‑DOPA) is the gold standard for symptomatic treatment of Parkinson's disease (PD); however, long‑term therapy is associated with the emergence of L‑DOPA‑induced dyskinesia (LID). Nigral dopaminergic cell loss determines the degree of drug exposure and time required for the initial onset of LID. Accumulating evidence indicates that α‑lipoic acid (ALA) decreases this nigral dopaminergic cell loss. However, until now, the precise mechanisms of ALA have only been partially understood in LID...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29112912/investigation-of-high-pressure-effect-on-the-structure-and-adsorption-of-%C3%AE-lactoglobulin
#19
K Kurpiewska, A Biela, J I Loch, S Świątek, B Jachimska, K Lewiński
β-Lactoglobulin, being one of the principal whey protein, is of huge importance to the food industry. Temperature/pressure effects on this small protein has been extensively studied by industry. To characterize biochemical properties of β-lactoglobulin after or during pressurization, a wide range of methods have been used thus far. In this study, for the first time, the pressure-induced conformation of β-lactoglobulin in the crystal state was determined, at pressure 430 MPa. Changes observed in the high pressure structure correlate with the physico-chemical properties of pressure-treated β-lactoglobulin obtained from dynamic light scattering, electrophoretic mobility and quartz crystal microbalance with dissipation monitoring measurements...
October 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29111213/prenatal-and-early-life-triclosan-and-parabens-exposure-and-allergic-outcomes
#20
Kathleen Lee-Sarwar, Russ Hauser, Antonia M Calafat, Xiaoyun Ye, George T O'Connor, Megan Sandel, Leonard B Bacharier, Robert S Zeiger, Nancy Laranjo, Diane R Gold, Scott T Weiss, Augusto A Litonjua, Jessica H Savage
BACKGROUND: In cross-sectional studies, triclosan and parabens, ubiquitous ingredients in personal care and other products, are associated with allergic disease. OBJECTIVES: We investigated the association between prenatal and early life triclosan and parabens exposure and childhood allergic disease in a prospective, longitudinal study. METHODS: Subjects were enrollees in VDAART, the Vitamin D Antenatal Asthma Reduction Trial. Triclosan, methyl paraben and propyl paraben concentrations were quantified in maternal plasma samples pooled from first and third trimesters and urine samples from children at age 3 or 4 years...
October 27, 2017: Journal of Allergy and Clinical Immunology
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