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https://www.readbyqxmd.com/read/27927214/antiplatelet-and-antithrombotic-effects-of-cordycepin-enriched-wib-801ce-from-cordyceps-militaris-ex-vivo-in-vivo-and-in-vitro
#1
Hyuk-Woo Kwon, Jung-Hae Shin, Deok Hwi Lim, Woo Jeong Ok, Gi Suk Nam, Min Ji Kim, Ho-Kyun Kwon, Jun-Hee Noh, Je-Young Lee, Hyun-Hong Kim, Jong-Lae Kim, Hwa-Jin Park
BACKGROUND: A species of the fungal genus Cordyceps has been used as a complementary and alternative medicine of traditional Chinese medicine, and its major component cordycepin and cordycepin-enriched WIB-801CE are known to have antiplatelet effects in vitro. However, it is unknown whether they have also endogenous antiplatelet and antithrombotic effects. In this study, to resolve these doubts, we prepared cordycepin-enriched WIB-801CE, an ethanol extract from Cordyceps militaris-hypha, then evaluated its ex vivo, in vivo, and in vitro antiplatelet and antithrombotic effects...
December 7, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27910792/optimization-of-liquid-fermentation-conditions-and-protein-nutrition-evaluation-of-mycelium-from-the-caterpillar-medicinal-mushroom-cordyceps-militaris-ascomycetes
#2
Jie Gang, Han Liu, Yanhong Liu
Cordyceps militaris is a well-known traditional Chinese medicinal mushroom. In this study, the mycelium of C. militaris was cultured using liquid fermentation technology and the culture medium components were optimized by the orthogonal test method. Our results showed that the optimal medium combination for the mycelium growth is 3% glucose, 3% peptone, 0.1% MgSO4, and 0.2% KH2PO4 The international general nutritional assessment method was applied to the overall evaluation of the protein nutrition value of submerged cultivated mycelium and fruit body of C...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27900943/collagen-type-iii-glomerulopathy-case-report-and-review-of-the-literature
#3
Xinghua Chen, Huiming Wang, Wanwen Xu, Jili Zhu
To summarize the clinical and pathological features of collagen type III glomerulopathy, the present report describes a case of collagen type III glomerulopathy and reviewed more than 60 cases recorded by other groups in English literature over the last few years. A 24-year-old female patient was admitted because of lower limbs edema, without any other discomforts. The lab examination of the patient reported proteinuria (2.42 g/24 h urine), microscopic hematuria, and the serum creatinine was 71 μmol/L. She received renal biopsy...
November 30, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27885803/rapid-and-sensitive-determination-of-phytosterols-in-functional-foods-and-medicinal-herbs-by-using-uhplc-ms-ms-with-microwave-assisted-derivatization-combined-with-dual-ultrasound-assisted-dispersive-liquid-liquid-microextraction
#4
Jing Sun, Xian-En Zhao, Jun Dang, Xiaoyan Sun, Longfang Zheng, Jinmao You, Xiao Wang
In this work, a hyphenated technique of dual ultrasound-assisted dispersive liquid-liquid microextraction combined with microwave-assisted derivatization followed by ultra high performance liquid chromatography tandem mass spectrometry has been developed for the determination of phytosterols in functional foods and medicinal herbs. Multiple reaction monitoring mode was used for the tandem mass spectrometry detection. A mass-spectrometry-sensitive reagent, 4'-carboxy-substituted rosamine, has been used as the derivatization reagent for five phytosterols, and internal standard diosgenin was used for the first time...
November 25, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27874103/cordyceps-collected-from-bhutan-an-appropriate-alternative-of-cordyceps-sinensis
#5
Ding-Tao Wu, Guang-Ping Lv, Jian Zheng, Qian Li, Shuang-Cheng Ma, Shao-Ping Li, Jing Zhao
Natural Cordyceps collected in Bhutan has been widely used as natural Cordyceps sinensis, an official species of Cordyceps used as Chinese medicines, around the world in recent years. However, whether Cordyceps from Bhutan could be really used as natural C. sinensis remains unknown. Therefore, DNA sequence, bioactive components including nucleosides and polysaccharides in twelve batches of Cordyceps from Bhutan were firstly investigated, and compared with natural C. sinensis. Results showed that the fungus of Cordyceps from Bhutan was C...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832180/cordyceps-militaris-treatment-preserves-renal-function-in-type-2-diabetic-nephropathy-mice
#6
Sung-Hsun Yu, Navneet Kumar Dubey, Wei-Shan Li, Ming-Che Liu, Han-Sun Chiang, Sy-Jye Leu, Ying-Hua Shieh, Feng-Chou Tsai, Win-Ping Deng
Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN. Hence, this study aimed to further investigate the renal injury-reducing effect of antidiabetic CmNo1, a novel combination of powders of fruiting bodies and mycelia of Cordyceps militaris. After being administered with streptozotocin-nicotinamide and high-fat-diet, the diabetic nephropathy mouse model displayed elevated blood glucose and renal dysfunction markers including serum creatinine and kidney-to-body weight ratio...
2016: PloS One
https://www.readbyqxmd.com/read/27747890/evaluation-of-different-agricultural-wastes-for-the-production-of-fruiting-bodies-and-bioactive-compounds-by-medicinal-mushroom-cordyceps-militaris
#7
Qunying Lin, Liangkun Long, Liangliang Wu, Fenglun Zhang, Shuling Wu, Weiming Zhang, Xiaoming Sun
BACKGROUND: In commercial production of Cordyceps militaris (a famous Chinese medicine), usually cereal grains were utilized as cultivation substrates. This study is aimed to evaluate the efficiency of agricultural wastes as substitute materials in the low cost production of C. militaris. Cottonseed shells (CS), corn cob particles (CCP), Italian poplar sawdusts (IPS) and substrates spent by Flammulina velutipes (SS) were employed to cultivate C. militaris, using rice medium as control...
October 17, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27723567/identification-of-chinese-medicinal-fungus-cordyceps-sinensis-by-depth-profiling-mid-infrared-photoacoustic-spectroscopy
#8
Changwen Du, Jianmin Zhou, Jianfeng Liu
With increased demand for Cordyceps sinensis it needs rapid methods to meet the challenge of identification raised in quality control. In this study Cordyceps sinensis from four typical natural habitats in China was characterized by depth-profiling Fourier transform infrared photoacoustic spectroscopy. Results demonstrated that Cordyceps sinensis samples resulted in typical photoacoustic spectral appearance, but heterogeneity was sensed in the whole sample; due to the heterogeneity Cordyceps sinensis was represented by spectra of four groups including head, body, tail and leaf under a moving mirror velocity of 0...
October 5, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27721890/dual-directional-immunomodulatory-effects-of-corbrin-capsule-on-autoimmune-thyroid-diseases
#9
Tianyi He, Ruxing Zhao, Yiran Lu, Wenjuan Li, Xinguo Hou, Yu Sun, Ming Dong, Li Chen
Purpose. To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD). Methods. 44 Patients with Graves's disease (GD) and 56 patients with Hashimoto's thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27717908/actions-of-water-extract-from-cordyceps-militaris-in-hyperuricemic-mice-induced-by-potassium-oxonate-combined-with-hypoxanthine
#10
Tianqiao Yong, Minglong Zhang, Diling Chen, Ou Shuai, Shaodan Chen, Jiyan Su, Chunwei Jiao, Delong Feng, Yizhen Xie
ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris was recorded in the classic traditional Chinese medicine book with the main functions of "protecting liver and enhancing kidney functions", influencing serum uric acid levels. AIM OF STUDY: The aim is to investigate the hypouricemic effects and possible mechanism of C. militaris in hyperuricemic mice. MATERIALS AND METHODS: A water extract (WECM) was prepared by decocting C. militaris directly at 80 (o)C in water bath, followed by lyophilization...
October 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27689974/cordycepin-induces-apoptosis-and-inhibits-proliferation-of-human-lung-cancer-cell-line-h1975-via-inhibiting-the-phosphorylation-of-egfr
#11
Zheng Wang, Xue Wu, Yan-Ni Liang, Li Wang, Zhong-Xing Song, Jian-Li Liu, Zhi-Shu Tang
Cordycepin is an active component of the traditional Chinese medicine Cordyceps sinensis and Cordyceps militaris with notable anticancer activity. Though the prominent inhibitory activity was reported in different kinds of cancer cell lines, the concrete mechanisms remain elusive. It was reported that cordycepin could be converted into tri-phosphates in vivo to confuse a number of enzymes and interfere the normal cell function. For the inhibitory mechanism of EGFR inhibitors and the structure similarity of ATP and tri-phosphated cordycepin, human lung cancer cell line H1975 was employed to investigate the inhibitory effect of cordycepin...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27667538/synthesis-characterization-and-antioxidant-activity-of-selenium-polysaccharide-from-cordyceps-militaris
#12
Zhen-Yuan Zhu, Fei Liu, Hui Gao, Huiqing Sun, Meng Meng, Yong-Min Zhang
A purified selenium-containing derivatives of Cordyceps militaris polysaccharide synthesized using H2SeO3/HNO3 and BaCl2 as a catalyst was investigated in this paper. The reaction condition was optimized by selecting different reaction temperature and period. Afterward, the one with the highest Se content was purified by ultra-filtration device with a molecular cut off size of 10KDa. Followed by its structural characterizations. Results of IFR and (13)C NMR spectroscopy indicated that C-6 substitution was predominant in selenized polysaccharide...
September 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27649728/effects-of-illumination-pattern-during-cultivation-of-fruiting-body-and-bioactive-compound-production-by-the-caterpillar-medicinal-mushroom-cordyceps-militaris-ascomycetes
#13
Chiu-Yeh Wu, Zeng-Chin Liang, Chin-Yin Tseng, Shu-Hui Hu
We investigated the effects of light intensity in the 3 cultivation stages separately-the mycelium colonization stage, the primordial initiation stage, and the fruiting stage (in order)-on fruiting body and bioactive compound production by Cordyceps militaris. In the mycelium colonization stage, rice substrates were incubated in a spawn running room at 23°C. During the primordial initiation stage, C. militaris was grown at 18°C and illuminated 12 hours/day. In the fruiting stage the temperature was 23°C, with illumination provided 12 hours/day...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27642126/biochemical-characterization-of-a-novel-fibrinolytic-enzyme-from-cordyceps-militaris
#14
Xiaolan Liu, Narasimha-Kumar Kopparapu, Yao Li, Yongping Deng, Xiqun Zheng
A fibrinolytic enzyme was produced by the medicinal mushroom, Cordyceps militaris using submerged fermentation. The enzyme was purified from culture supernatant by hydrophobic interaction, ion exchange and gel filtration chromatographies. It was purified by 36 fold, with a specific activity of 1,467.4U/mg protein and the final yield was 5.8%. The molecular weight of the enzyme as determined by SDS-PAGE and gel filtration was 28kDa and 24.5kDa, respectively, and its isoelectric point (pI) was 9.0±0.2. It was found to be a glycoprotein with carbohydrate content of 1...
September 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27625176/high-throughput-sequencing-based-analysis-of-endogenetic-fungal-communities-inhabiting-the-chinese-cordyceps-reveals-unexpectedly-high-fungal-diversity
#15
Fei Xia, Xin Chen, Meng-Yuan Guo, Xiao-Hui Bai, Yan Liu, Guang-Rong Shen, Yu-Ling Li, Juan Lin, Xuan-Wei Zhou
Chinese Cordyceps, known in Chinese as "DongChong XiaCao", is a parasitic complex of a fungus (Ophiocordyceps sinensis) and a caterpillar. The current study explored the endogenetic fungal communities inhabiting Chinese Cordyceps. Samples were collected from five different geographical regions of Qinghai and Tibet, and the nuclear ribosomal internal transcribed spacer-1 sequences from each sample were obtained using Illumina high-throughput sequencing. The results showed that Ascomycota was the dominant fungal phylum in Chinese Cordyceps and its soil microhabitat from different sampling regions...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27611774/structure-revision-of-an-acorane-sesquiterpene-cordycepol-a
#16
D Sai Reddy, Andrei G Kutateladze
Structure revision of a recently reported spirodecane sesquiterpene, cordycepol A, from fungi Cordyceps ophioglossoides was enabled by fast and accurate calculations of nuclear spin-spin coupling constants (SSCCs) with a relativistic force field (DU8c) parametric method. Two other reported cordycepols, B and C, are also identified as misassigned. Calculations of accurate SSCCs, which contain a wealth of structural information, offer a chemically intuitive tool for structure elucidation, rendering the whole structure revision process more guided and intentional, while augmenting in a synergistic way the calculations of chemical shifts...
October 7, 2016: Organic Letters
https://www.readbyqxmd.com/read/27604096/synergistic-antitumor-efficacy-of-antibacterial-helvolic-acid-from-cordyceps-taii-and-cyclophosphamide-in-a-tumor-mouse-model
#17
Jian-Hui Xiao, Yao Zhang, Gui-You Liang, Ru-Ming Liu, Xiao-Gang Li, Ling-Tao Zhang, Dai-Xiong Chen, Jian-Jiang Zhong
The antibacterial agent helvolic acid, which was isolated from the active antitumor fraction of Cordyceps taii, showed potent cytotoxicity against different human cancer cells. In the present study, the in vivo antitumor effect of helvolic acid was investigated in murine sarcoma S180 tumor-bearing mice. Doses of 10 and 20 mg/kg/day helvolic acid did not exert significant antitumor activity. Interestingly, co-administration of 10 mg/kg/day helvolic acid and 20 mg/kg/day cyclophosphamide (CTX) - a well-known chemotherapy drug - showed promising antitumor activity with a growth inhibitory rate of 70...
September 6, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27588098/separation-of-cordycepin-from-cordyceps-militaris-fermentation-supernatant-using-preparative-hplc-and-evaluation-of-its-antibacterial-activity-as-an-nad-dependent-dna-ligase-inhibitor
#18
Xiaofeng Zhou, Guoqiang Cai, Yi He, Guotong Tong
Cordycepin exhibits various bio-activities, including anticancer, antibacterial, antiviral and immune regulation activities, and is a significant focus of research. However, the preparation of high-purity cordycepin remains challenging. Also, the molecular target with which cordycepin interacts to cause an antibacterial effect remains unknown. In the present study, cordycepin was prepared by preparative high-performance liquid chromatography (prep-HPLC) and the purity obtained was 99.6%, indicating that this technique may be useful for the large-scale isolation of cordycepin in the future...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27567378/preparative-isolation-of-cordycepin-n-6-2-hydroxyethyl-adenosine-and-adenosine-from-cordyceps-militaris-by-macroporous-resin-and-purification-by-recycling-high-speed-counter-current-chromatography
#19
Zhong Zhang, Tuernisan Tudi, Yanfang Liu, Shuai Zhou, Na Feng, Yan Yang, Chuanhong Tang, Qingjiu Tang, Jingsong Zhang
In this study, cordycepin, N(6)-(2-hydroxyethyl)-adenosine (HEA) and adenosine from the fruiting bodies of Cordyceps militaris were separated by using macroporous resin NKA-II adsorption. The parameters of static adsorption were tested and the optimized conditions were as follow: the total adsorption time was 12h, 50% ethanol was used for desorption and the desorption time was 9h. The crude sample that was prepared by macroporous resin NKA-II contained 3.4% cordycepin, 3.7% HEA and 4.9% adenosine. Then the crude sample was further purified by recycling high-speed counter-current chromatography (HSCCC) with ethyl acetate, n-butanol, 1...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27565291/preparation-and-inhibition-on-%C3%AE-d-glucosidase-of-low-molecular-weight-polysaccharide-from-cordyceps-militaris
#20
Zhen-Yuan Zhu, Ming-Zhu Guo, Fei Liu, You Luo, Lu Chen, Meng Meng, Xiao-Ting Wang, Yong-Min Zhang
The structural properties and the inhibition on α-d-glucosidase activity of the low molecular weight (LCMPs-II) obtained from the optimized acid hydrolysis of the Cordyceps militaris polysaccharides (CMPs) were investigated in this paper. The LCMPs-II with a molecular weight of 28 KDa mainly composed of rhamnose, xylose and glucose with the molar ratio of 1: 2.19: 6.73 was separated from LCMPs-I which was the acid hydrolysis product of CMPs by chromatography on Sephadex G-100 column. The solubility of LCMPs-II was tested to be 32...
August 23, 2016: International Journal of Biological Macromolecules
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