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https://www.readbyqxmd.com/read/29775778/the-genus-cordyceps-an-extensive-review-of-its-traditional-uses-phytochemistry-and-pharmacology
#1
REVIEW
Opeyemi Joshua Olatunji, Jian Tang, Adesola Tola, Florence Auberon, Omolara Oluwaniyi, Zhen Ouyang
The genus Cordyceps has about 750 identified species which are distributed in many regions of the World, but mainly found in South Asia, Europe and North America. The species of the genus are highly priced and are widely used as food and medicine for the treatment of various ailments. This present review compiles literature information on the ethno-medicinal, phytochemistry and pharmacological properties of species in the genus Cordyceps. In addition, the review also suggest recommendations for the future researches...
May 15, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29754506/hirsutella-sinensis-inhibits-lewis-lung-cancer-via-tumor-microenvironment-effector-t-cells-in-mice
#2
Huiying Fu, Lu Jin, Xia Shao, Yuanyuan Li, Fangming Chen, Zhiqiang Shou, Xiaofang Tang, Bing Ji, Qiyang Shou
Hirsutella sinensis fungus (HSF) is an artificial substitute of the well-known medicine Cordyceps sinensis with similar beneficial effects in humans. We previously found that HSF can regulate immune function and inhibit tumor growth; however, the mechanisms involved in these effects were still unclear. Accordingly, in this study, we investigated the effects of HSF on immune cell subsets in the tumor microenvironment in mice. The results showed that HSF inhibited Lewis lung cancer growth, alleviated abnormalities in routine blood tests, and enhanced tumor-infiltrating T cells, particularly the proportion of effector CD8[Formula: see text] T cells...
May 13, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29753871/combinatorial-usage-of-fungal-polysaccharides-from-cordyceps-sinensis-and-ganoderma-atrum-ameliorate-drug-induced-liver-injury-in-mice
#3
Songtao Fan, Xiaojun Huang, Sunan Wang, Chang Li, Zhihong Zhang, Mingyong Xie, Shaoping Nie
This study investigated the possible protective effect of combined fungal polysaccharides (CFP), consisting of Cordyceps sinensis polysaccharides (CSP) and Ganoderma atrum polysaccharides (PSG) with well-defined structural characteristics, against cyclophosphamide (CTX)-induced hepatotoxicity in mice. Our results indicated CFP effectively prevented the liver injury by decreasing toxicity markers (aspartate transaminase, alanine aminotransferase and alkaline phosphatase). Further biochemical and molecular analysis indicated CSP particularly inhibited the activation of Toll-like receptor 9 (TLR9) and its related inflammatory signals, including pro-inflammatory cytokines, inducible nitric oxide synthase, and cyclooxygenase-2 to modulate hepatic inflammation response...
May 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29752731/metabolomic-comparison-between-wild-ophiocordyceps-sinensis-and-artificial-cultured-cordyceps-militaris
#4
Lin Chen, Yuetao Liu, Qingfeng Guo, Qingxia Zheng, Wancun Zhang
In this study, a systematic research on the metabolome differences between wild Ophiocordyceps sinensis (O. sinensis) and artificial cultured Cordyceps militaris (C. militaris) was conducted using liquid chromatography-mass spectrometry. Principal components analysis (PCA) and Orthogonal projection on latent structure-discriminant analysis (OPLS-DA) results showed that C. militaris grown on solid rice medium (R-CM) and C. militaris grown on tussah pupa (T-CM) evidently separated and individually separated from wild O...
May 11, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29744278/proteomic-identification-of-marker-proteins-and-its-application-to-authenticate-ophiocordyceps-sinensis
#5
Xinxin Tong, Yixuan Wang, Zhengyao Xue, Lu Chen, Yi Qiu, Jing Cao, Cheng Peng, Jinlin Guo
Ophi o cordyceps sinensis ( O. sinensis ) is a highly valuable fungus because of its nutritious and medicinal properties. The objective of this study was to identify protein markers using a proteomics approach followed by the development of an immunoassay to authenticate O. sinensis . Four authentic O. sinensis samples collected from four production regions and four counterfeit samples were examined individually. Overall 22 characteristic proteins of O. sinensis were identified by two-dimensional electrophoresis (2-DE) coupled with the matrix-assisted laser desorption/ionization-time-of-light mass spectrometry (MALDI-TOF/MS)...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29736181/improvement-of-learning-and-memory-induced-by-cordyceps-polypeptide-treatment-and-the-underlying-mechanism
#6
Guangxin Yuan, Liping An, Yunpeng Sun, Guangyu Xu, Peige Du
Our previous research revealed that Cordyceps militaris can improve the learning and memory, and although the main active ingredient should be its polypeptide complexes, the underlying mechanism of its activity remains poorly understood. In this study, we explored the mechanisms by which Cordyceps militaris improves learning and memory in a mouse model. Mice were given scopolamine hydrobromide intraperitoneally to establish a mouse model of learning and memory impairment. The effects of Cordyceps polypeptide in this model were tested using the Morris water maze test; serum superoxide dismutase activity; serum malondialdehyde levels; activities of acetyl cholinesterase, Na+-k+-ATPase, and nitric oxide synthase; and gamma aminobutyric acid and glutamate contents in brain tissue...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29686726/hplc-icp-ms-speciation-analysis-and-risk-assessment-of-arsenic-in-cordyceps-sinensis
#7
Tian-Tian Zuo, Yao-Lei Li, Hong-Yu Jin, Fei Gao, Qi Wang, Ya-Dan Wang, Shuang-Cheng Ma
Background: Cordyceps sinensis , one of the most valued traditional herbal medicines in China, contains high amount of arsenic. Considering the adverse health effects of arsenic, this is of particular concern. The aim of this study was to determine and analyze arsenic speciation in C. sinensis , and to measure the associated human health risks. Methods: We used microwave extraction and high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry to determine and analyze the arsenic content in C...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29671341/chemical-study-of-the-strain-cordyceps-spp-from-cell-fusion-between-cordyceps-militaris-and-cordyceps-cicadae
#8
Ning-Ning Yang, Ning Jiang, Qing-Yun Ma, Fan-Dong Kong, Qing-Yi Xie, Li-Man Zhou, Zhi-Fang Yu, You-Xing Zhao
Chemical investigation on the cultures of the fungus Cordyceps spp., a strain from cell fusion between Cordyceps militaris and Cordyceps cicadae, resulted in the isolation of 13 compounds including 2 new ones named 2-(5-(3-oxobutyl) furan-2-yl) acetic acid (1) and cordycepone (2). Their structures were elucidated from the analysis of 1D/2D NMR and CD data. Among them, compounds 1, 7-9, at a concentration of 50 μg/ml, showed weak inhibitory activity against AChE. Moreover, compounds 6, 9, and 11 showed moderate inhibitory activity against the nematode Panagrellus redivivus with mortality ratio of 79...
April 19, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29667669/structural-characterization-and-antitumor-activity-of-a-novel-se-polysaccharide-from-selenium-enriched-cordyceps-gunnii
#9
Huiqing Sun, Zhenyuan Zhu, Yali Tang, Yuanyuan Ren, Qiaoying Song, Yun Tang, Yongmin Zhang
Selenium (Se) has been recognized as an essential element. Animals and humans absorb and retain more organic Se than inorganic Se. Bio-transformation is a major approach to transform inorganic Se to organic Se. Cordyceps gunnii (C. gunnii), well known as a Chinese edible and medicinal fungus, has a variety of biological functions. C. gunnii and selenium were combined through liquid-fermentation to obtain selenium-enriched C. gunnii. A novel Se-polysaccharide (SeCPS-II) was extracted from selenium-enriched C...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29666196/whole-genome-sequence-of-an-edible-and-potential-medicinal-fungus-cordyceps-guangdongensis
#10
Chenghua Zhang, Wangqiu Deng, Wenjuan Yan, Taihui Li
Cordyceps guangdongensis is an edible fungus which was approved as a novel food by the Chinese Ministry of Public Health in 2013. It also has a broad prospect of application in pharmaceutical industries, with many medicinal activities. In this study, the whole genome of C. guangdongensis GD15, a single spore isolate from a wild strain, was sequenced and assembled with Illumina and PacBio sequencing technology. The generated genome is 29.05 Mb in size, comprising nine scaffolds with an average GC content of 57...
April 17, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29626602/protective-properties-of-combined-fungal-polysaccharides-from-cordyceps-sinensis-and-ganoderma-atrum-on-colon-immune-dysfunction
#11
Song-Tao Fan, Shao-Ping Nie, Xiao-Jun Huang, Sunan Wang, Jie-Lun Hu, Jun-Hua Xie, Qi-Xing Nie, Ming-Yong Xie
In vivo an ecological network of polysaccharides utilization by gut microbiota is not only an intense competition but also an impressive cooperation pattern. The present study evaluated the in vivo protective effect of combined fungal polysaccharides (CFP) from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction, induced by 150 mg/kg cyclophosphamide (CP). The results showed that C. sinensis polysaccharides (CSP) significantly promoted microbial-derived butyrate to improve histone h3 acetylation mediating regulatory T (Treg) cell specific Foxp3, as well as significantly restored CP-induced elevation of interleukin (IL)-17 and IL-21...
April 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29609095/a-comparative-proteomic-characterization-and-nutritional-assessment-of-naturally-and-artificially-cultivated-cordyceps-sinensis
#12
Xu Zhang, Qun Liu, Wei Zhou, Ping Li, Raphael N Alolga, Zhenming Qian, Wenjia Li, Lian-Wen Qi, Xiaojian Yin
Cordyceps sinensis has gained increasing attention due to its nutritional and medicinal properties. Herein, we employed label-free quantitative mass spectrometry to explore the proteome differences between naturally- and artificially-cultivated C. sinensis. A total of 22,829 peptides with confidence ≥95%, corresponding to 2541 protein groups were identified from the caterpillar bodies/stromata of 12 naturally- and artificially-cultivated samples of C. sinensis. Among them, 341 proteins showed significant differences between the samples of natural and artificial cultivation...
March 30, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29606739/effects-of-cordyceps-militaris-l-fr-fermentation-on-the-nutritional-physicochemical-functional-properties-and-angiotensin-i-converting-enzyme-inhibitory-activity-of-red-bean-phaseolus-angularis-willd-w-f-wight-flour
#13
Yu Xiao, Mingmei Sun, Qiuqin Zhang, Yulian Chen, Junqing Miao, Xin Rui, Mingsheng Dong
The effects of solid-state fermentation with Cordyceps militaris (L.) Fr. on the nutritional, physicochemical, and functional properties as well as angiotensin I converting enzyme (ACE) inhibitory activity of red bean ( Phaseolus angularis [Willd.] W.F. Wight.) flour were determined. Fermentation increased the amount of small peptides but significantly decreased large peptides. Fermentation also increased proteins and essential amino acids (by 9.31 and 13.89%, respectively) and improved the in vitro protein digestibility (6...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29605840/targeted-gene-deletion-in-cordyceps-militaris-using-the-split-marker-approach
#14
HaiWei Lou, ZhiWei Ye, Fan Yun, JunFang Lin, LiQiong Guo, BaiXiong Chen, ZhiXian Mu
The macrofungus Cordyceps militaris contains many kinds of bioactive ingredients that are regulated by functional genes, but the functions of many genes in C. militaris are still unknown. In this study, to improve the frequency of homologous integration, a genetic transformation system based on a split-marker approach was developed for the first time in C. militaris to knock out a gene encoding a terpenoid synthase (Tns). The linear and split-marker deletion cassettes were constructed and introduced into C...
March 31, 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29604913/antioxidant-activity-of-water-extract-from-fermented-mycelia-of-cordyceps-sobolifera-ascomycetes-in-caenorhabditis-elegans
#15
Qun-Ying Lin, Liang-Kun Long, Zi-Heng Zhuang, Liang-Liang Wu, Shu-Ling Wu, Wei-Ming Zhang
This research aimed to evaluate the potential of Cordyceps sobolifera in mycelial biomass production via liquid culture and to assay the safety and determine the antioxidative and antiaging activities of Caenorhabditis elegans. A C. sobolifera isolate was cultured using the one-factor-at-a-time method to illustrate its carbon and nitrogen requirements. To assess safety, we determined the lethality, locomotion behavior, and reproduction of C. elegans cultured on a mycelial water extract (MWE) containing nematode growth medium (NGM)...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29600609/-comparison-and-review-on-specifications-of-fermented-cordyceps-sinensis-products
#16
REVIEW
Ping Yang, Xiao-Xia Zhao, Yong-Wen Zhang
There are five kinds of fermented Cordyceps crude drug and their preparations that have been approved as medicine on the market. Since the initial strains of the crude drug were all isolated from natural Cordyceps sinensis, they have similar names, chemical components and even clinical applications. However, because of the different strain species and fermentation processes, there was significant difference in quality. As a result, they should be clearly distinguished in clinical use. Most of the products were researched and developed during the 1980s and 1990s, so there was difference in quality standards for different products, and their quality control levels of some products were not perfect...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29594343/heat-and-light-stresses-affect-metabolite-production-in-the-fruit-body-of-the-medicinal-mushroom-cordyceps-militaris
#17
Zhang Jiaojiao, Wang Fen, Liu Kuanbo, Liu Qing, Yang Ying, Dong Caihong
Cordyceps militaris is a highly valued edible and medicinal fungus due to its production of various metabolites, including adenosine, cordycepin, N6 -(2-hydroxyethyl)-adenosine, and carotenoids. The contents of these metabolites are indicative of the quality of commercially available fruit body of this fungus. In this work, the effects of environmental abiotic factors, including heat and light stresses, on the fruit body growth and metabolite production in C. militaris were evaluated during the late growth stage...
March 29, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29576711/-cordyceps-militaris-fraction-induces-apoptosis-and-g2-m-arrest-via-c-jun-n-terminal-kinase-signaling-pathway-in-oral-squamous-carcinoma-kb-cells
#18
Wangshi Xie, Zhang Zhang, Liyan Song, Chunhua Huang, Zhongyi Guo, Xianjing Hu, Sixue Bi, Rongmin Yu
Background: Cordyceps militaris fraction (CMF) has been shown to possess in vitro antitumor activity against human chronic myeloid leukemia K562 cells in our previous research. Materials and Methods: The in vitro inhibitory activities of CMF on the growth of KB cells were evaluated by viability assay. The apoptotic and cell cycle influences of CMF were detected by 4',6-diamidino-2-phenylindole staining and flow cytometry assay. The expression of different apoptosis-associated proteins and cell cycle regulatory proteins was examined by Western blot assay...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29568244/herbal-medicine-for-sports-a-review
#19
REVIEW
Maha Sellami, Olfa Slimeni, Andrzej Pokrywka, Goran Kuvačić, Lawrence D Hayes, Mirjana Milic, Johnny Padulo
The use of herbal medicinal products and supplements has increased during last decades. At present, some herbs are used to enhance muscle strength and body mass. Emergent evidence suggests that the health benefits from plants are attributed to their bioactive compounds such as Polyphenols, Terpenoids, and Alkaloids which have several physiological effects on the human body. At times, manufacturers launch numerous products with banned ingredient inside with inappropriate amounts or fake supplement inducing harmful side effect...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29555964/publisher-correction-fungus-larva-relation-in-the-formation-of-cordyceps-sinensis-as-revealed-by-stable-carbon-isotope-analysis
#20
Lian-Xian Guo, Yue-Hui Hong, Qian-Zhi Zhou, Qing Zhu, Xiao-Ming Xu, Jiang-Hai Wang
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 19, 2018: Scientific Reports
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