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https://www.readbyqxmd.com/read/28221702/localized-and-controlled-delivery-of-nitric-oxide-to-the-conventional-outflow-pathway-via-enzyme-biocatalysis-toward-therapy-for-glaucoma
#1
Rona Chandrawati, Jason Y H Chang, Ester Reina-Torres, Coline Jumeaux, Joseph M Sherwood, W Daniel Stamer, Alexander N Zelikin, Darryl R Overby, Molly M Stevens
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. An NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28221333/idiopathic-bilateral-profound-hypotony-in-an-unknown-progressive-neurodegenerative-disorder
#2
Lorraine M Provencher, Pamela C Carter, Wallace L M Alward
PURPOSE: To present a unique case of idiopathic bilateral hypotony in a patient with progressive, undiagnosed neurological decline, possibly due to mitochondrial disease, and to explore mechanisms of disease and potential treatment options. METHODS: This is a case report. PATIENT: A 17-year-old boy with a history of chronic progressive bilateral vision loss and hypotony in the setting of progressive gait abnormalities, lower extremity spasticity, nystagmus, and urinary retention starting around age 8...
February 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28220640/multidimensional-contractile-reserve-predicts-adverse-outcome-in-patients-with-severe-systolic-heart-failure-a-4-year-follow-up-study
#3
Ioannis A Paraskevaidis, Ignatios Ikonomidis, Panagiotis Simitsis, John Parissis, Vasilios Stasinos, George Makavos, John Lekakis
AIMS: Left ventricular contractile reserve is a prognostic indicator for adverse outcome in patients with severe chronic heart failure with reduced ejection fraction (HFrEF). We investigated the dobutamine-induced changes of LV multidimensional deformation and their predictive value for cardiac mortality of patients with severe chronic HFrEF. METHODS AND RESULTS: In this prospective study, out of 130 patients with severe HFrEF who underwent a low-dose dobutamine stress echocardiography (LDSE) study using speckle tracking imaging, 100 patients were followed up for the occurrence of cardiac death over a period of 4 years...
February 21, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28219848/bioelectronic-neuromodulation-of-the-paravertebral-cardiac-efferent-sympathetic-outflow-and-its-effect-on-ventricular-electrical-indices
#4
Una Buckley, Ray W Chui, Pradeep S Rajendran, Tina Vrabec, Kalyanam Shivkumar, Jeffrey L Ardell
INTRODUCTION: Neuromodulation of the paravertebral ganglia, using symmetric voltage controlled kilohertz frequency alternating current (KHFAC), has the potential to be a reversible alternative to surgical intervention in patients with refractory ventricular arrhythmias. KHFAC creates scalable focal inhibition of action potential conduction. OBJECTIVE: To evaluate the efficacy of KHFAC, when applied to T1-T2 paravertebral chain, to mitigate sympathetic outflow to the heart...
February 17, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28219578/valved-conduit-attached-to-left-ventricular-outflow-tract-for-valve-detachment-in-beh%C3%A3-et-s-disease
#5
Liang-Wan Chen, Xi-Jie Wu, Hua Cao, Xiao-Fu Dai
Standard aortic valve replacement for aortic regurgitation caused by Behçet's disease is frequently complicated by postoperative recurrent prosthetic valve detachment. To prevent this, we have developed a modified Bentall procedure, in which the valved conduit is proximally attached to the left ventricular outflow tract instead of to the fragile annulus, based on the fact that the left ventricular outflow tract myocardium is rarely involved in Behçet's disease. This modified Bentall procedure was performed in 5 Behçet's disease patients with prosthetic valve detachment after primary aortic valve replacement, and satisfactory results were achieved...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219558/right-ventricular-hemangioma-in-the-outflow-tract-a-rare-cause-of-obstruction
#6
Amy M Young, Matthew R Danter, James S Lewis, Ben R Barton
We present a patient with a right ventricular hemangioma and symptomatic right ventricular outflow tract obstruction.
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219555/right-ventricular-outflow-tract-obstruction-due-to-immunoglobulin-g4-related-disease
#7
Masaru Ishida, Taichi Sakaguchi, Shigeru Miyagawa, Hiroyuki Nishi, Yasushi Yoshikawa, Satsuki Fukushima, Ai Kawamura, Takayoshi Ueno, Hatsue Ishibashi-Ueda, Yoshiki Sawa
A 64-year-old man with extensive tumorous infiltration of the pulmonary valve underwent partial resection of a tumor of the right ventricular outflow tract and replacement of the affected valve. A diagnosis of immunoglobulin-G4 related disease of the heart was made based on the immunohistologic findings. One year after the surgical resection, growth of the tumorous mass was observed, and steroid therapy was initiated. He had no sign of tumor progression four years after the steroid therapy.
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28218364/stenoses-in-the-surgically-manipulated-segment-have-better-angioplasty-response-compared-to-the-surgically-naive-segment-in-fistulas
#8
Jie Cui, Dihua Xu, Jie Ma, Bingyan Liu, Tatsuo Kawai, Heidi Yeh, Robert Schainfeld, Zubin Irani
PURPOSE: Balloon angioplasty is the standard treatment for dysfunctional hemodialysis fistulas, but angioplasty response of stenotic lesions located in different segments of the dialysis circuit has not been explicitly evaluated. The purpose of this study is to describe the distribution of stenotic lesions in the most common types of arteriovenous fistulas and to investigate the response to balloon angioplasty of stenotic lesions located in various segments of the fistula circuit. MATERIALS AND METHODS: This single-center, retrospective study was approved by the Institutional Review Board...
February 15, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28218213/surgical-treatment-of-double-outlet-right-ventricle-complicated-by-pulmonary-hypertension
#9
Qing-Yu Wu, Dong-Hai Li, Hong-Yin Li, Ming-Kui Zhang, Zhong-Hua Xu, Hui Xue
BACKGROUND: Double outlet right ventricle (DORV) is a group of complex congenital heart abnormalities. Preoperative pulmonary hypertension (PH) is considered an important risk factor for early death during the surgical treatment of DORV. The aim of this study was to report our experience on surgical treatment of DORV complicated by PH. METHODS: From June 2004 to November 2016, 61 patients (36 males and 25 females) aged 2 weeks to 26 years (median: 0.67 years and interquartile range: 0...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28217226/functional-characteristics-of-left-ventricular-synchronization-via-right-ventricular-outflow-tract-pacing-detected-by-two-dimensional-strain-echocardiography
#10
Yasutaka Hirayama, Yuichiro Kawamura, Nobuyuki Sato, Tatsuya Saito, Hideichi Tanaka, Yasuaki Saijo, Kenjiro Kikuchi, Katsumi Ohori, Naoyuki Hasebe
BACKGROUND: Recently, due to the detrimental effects on the ventricular function associated with right ventricular apical (RVA) pacing, right ventricular septal (RVS) pacing has become the preferred pacing method. However, the term RVS pacing refers to both right ventricular outflow-tract (RVOT) and mid-septal (RVMS) pacing, leading to a misinterpretation of the results of clinical studies. The purpose of this study, therefore, was to elucidate the functional differences of RVA, RVOT, and RVMS pacing in patients with atrioventricular block...
February 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28216476/combined-use-of-directional-atherectomy-and-drug-coated-balloon-for-the-endovascular-treatment-of-common-femoral-artery-disease-immediate-and-one-year-outcomes
#11
Angelo Cioppa, Eugenio Stabile, Luigi Salemme, Grigore Popusoi, Armando Pucciarelli, Fortunato Iacovelli, Antonella Arcari, Enrico Coscioni, Bruno Trimarco, Giovanni Esposito, Tullio Tesorio
AIMS: Surgical endarterectomy is the therapy of choice for atherosclerotic common femoral artery (CFA) obstruction. Recently, some large single-centre series have shown encouraging results for the percutaneous treatment of CFA obstructions. The purpose of this study was to evaluate the safety, feasibility, and one-year efficacy of the endovascular treatment of CFA obstructions with combined use of directional atherectomy (DA) and a paclitaxel-coated balloon (DCB). METHODS AND RESULTS: Between January 2012 and July 2014, 30 consecutive patients with severely calcified obstructions of the common femoral artery were treated in our centre using DA followed by DCB dilatation...
February 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28216473/five-year-results-from-a-prospective-multicentre-study-of-percutaneous-pulmonary-valve-implantation-demonstrate-sustained-removal-of-significant-pulmonary-regurgitation-improved-right-ventricular-outflow-tract-obstruction-and-improved-quality-of-life
#12
Alfred Hager, Stephan Schubert, Peter Ewert, Lars Søndergaard, Maarten Witsenburg, Paolo Guccione, Lee N Benson, José Suárez de Lezo, Te-Hsin Lung, John Hess, Andreas Eicken, Felix Berger
AIMS: Percutaneous pulmonary valve implantation (PPVI) is used to treat patients with dysfunctional pulmonary valve conduits. Short- and longer-term results from multiple trials have outlined haemodynamic improvements. Our aim was to report the long-term results, including quality of life, from a multicentre trial in Europe and Canada. METHODS AND RESULTS: From October 2007 to April 2009, 71 patients (24 female; median age 19.0 [IQR: 14.0 to 25.0] years) were enrolled in a prospective cohort study...
February 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28216204/left-ventricular-assist-device-thrombosis-is-associated-with-an-increase-in-the-systolic-to-diastolic-velocity-ratio-measured-at-the-inflow-and-outflow-cannulae
#13
Ankit Jain, Ben Rohrer, Brian Gebhardt, Janis L Breeze, Joshua D Quick, Gregory Couper, Michael S Kiernan, Matthew Lawrence, Frederick C Cobey
OBJECTIVE: To determine whether the ratio of peak systolic-to-nadir diastolic velocity (S/D ratio) measured using Doppler at the left ventricular assist device (LVAD) inflow and outflow cannulae is associated with pump thrombosis and to determine whether there is an absolute decrease in the diastolic cannula velocities in LVAD thrombosis. DESIGN: Retrospective chart review. SETTING: University hospital. PARTICIPANTS: Patients who underwent LVAD exchange...
November 24, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28216201/intratracheal-milrinone-bolus-administration-during-acute-right-ventricular-dysfunction-after-cardiopulmonary-bypass
#14
Caroline Eva Gebhard, Georges Desjardins, Cathérine Gebhard, Paul Gavra, André Y Denault
OBJECTIVE: To evaluate intratracheal milrinone (tMil) administration for rapid treatment of right ventricular (RV) dysfunction as a novel route after cardiopulmonary bypass. DESIGN: Retrospective analysis. SETTING: Single-center study. PARTICIPANTS: The study comprised 7 patients undergoing cardiac surgery who exhibited acute RV dysfunction after cardiopulmonary bypass. INTERVENTIONS: After difficult weaning caused by cardiopulmonary bypass-induced acute RV dysfunction, milrinone was administered as a 5-mg bolus inside the endotracheal tube...
November 22, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28215512/angiosome-targeted-pta-is-more-important-in-endovascular-revascularisation-than-in-surgical-revascularisation-analysis-of-545-patients-with-ischaemic-tissue-lesions
#15
K Špillerová, N Settembre, F Biancari, A Albäck, M Venermo
INTRODUCTION: This study aimed to evaluate the impact of angiosome targeted (direct) revascularisation according to revascularisation method in patients with diabetes. MATERIALS AND METHODS: This retrospective study cohort comprised 545 diabetic patients with critical limb ischaemia and tissue loss (Rutherford 5, 6). All patients underwent infrapopliteal endovascular (PTA) or open surgical revascularisation between January 2008 and December 2013. Differences in the outcome after direct revascularisation, bypass surgery, and PTA were investigated by means of Cox proportional hazards analysis...
February 16, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28215078/contribution-of-leaf-litter-to-nutrient-export-during-winter-months-in-an-urban-residential-watershed
#16
Anika Rose Bratt, Jacques C Finlay, Sarah E Hobbie, Benjamin D Janke, Adam C Worm, Kathrine L Kemmitt
Identification of non-point sources of nitrogen (N) and phosphorus (P) in urban systems is imperative to improve water quality and better manage eutrophication. Winter contributions and sources of annual N and P loads from urban watersheds are poorly characterized in northern cities because monitoring is often limited to warm weather periods. To determine winter export of N and P, we monitored storm water outflow in a residential watershed in Saint Paul, Minnesota during 2012-2014. Our data demonstrate that winter melt events contribute a high percentage of annual N and P export (50%)...
February 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28214505/positional-right-ventricular-obstruction-in-pectus-excavatum
#17
Katherine Underwood, Matthew Vorsanger, Muhamed Saric, Adam H Skolnick
Pectus excavatum is one of the most common congenital chest wall deformities. The degree of sternal depression, which may result in compression of the right heart by the chest wall, is variable. While typically asymptomatic, there are various symptoms that can result from severe pectus excavatum. We report on a patient with severe pectus excavatum leading to dynamic obstruction of the right ventricular outflow tract in the seated position.
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28212738/delayed-efficacy-of-radiofrequency-catheter-ablation-on-ventricular-arrhythmias-originating-from-the-left-ventricular-anterobasal-wall
#18
Ligang Ding, Bingbo Hou, Lingmin Wu, Yu Qiao, Wei Sun, Jinrui Guo, Lihui Zheng, Gang Chen, Linfeng Zhang, Shu Zhang, Yan Yao
BACKGROUND: Ventricular arrhythmias (VAs) originating from the left ventricular anterobasal wall (LV-ABW) may represent a therapeutic challenge. OBJECTIVE: The purpose of this study was to investigate the delayed efficacy of radiofrequency catheter (RFCA) ablation without an epicardial approach on VAs originating from the LV-ABW. METHODS: Eighty patients (mean age 46.9 ± 14.9 years; 47 male) with VAs originating from the LV-ABW were enrolled...
March 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28209236/epithelial-downgrowth-report-of-2-cases-diagnosed-by-ocular-biopsy
#19
REVIEW
Hershel R Patel, Curtis E Margo
Epithelial downgrowth is an uncommon complication of ocular surgery or adverse consequence of accidental trauma, caused by surface squamous epithelium that has gained access to the inner compartments of the eye. Once embedded in the eye, squamous epithelium spreads over contiguous structures, interfering with normal aqueous outflow and vision. The pursuit of improved therapies is ongoing, but the greatest chance of preventing blindness is with early recognition. Two cases of epithelial downgrowth diagnosed from a corneal button and an iris biopsy are presented to familiarize pathologists with this disorder...
February 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28208950/cerebral-venous-thrombosis-in-pregnancy-a-poignant-allegory-of-an-unusual-case
#20
Sheeba Marwah, Gaikwad Harsha Shailesh, Sumedha Gupta, Manjula Sharma, Pratima Mittal
Cerebral Venous Thrombosis (CVT), also known as cortical venous, cerebral sinus, cerebral venous sinus, or dural sinus thrombosis, is an infrequent grave condition affecting pregnant females, resulting from clot formation in one of the many outflow tracts of the brain. Although pregnancy-associated stroke or CVT is uncommon, the risk of stroke is greatly increased above the low baseline rate in young patients during late pregnancy and, even more so, during the puerperium. Haemorrhagic infarction can occur in the acute stage of CVT...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
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