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https://www.readbyqxmd.com/read/29346804/trabodenoson-an-adenosine-mimetic-with-a1-receptor-selectivity-lowers-intraocular-pressure-by-increasing-conventional-outflow-facility-in-mice
#1
Guorong Li, Karen Y Torrejon, Andrea M Unser, Feryan Ahmed, Iris D Navarro, Rudolf A Baumgartner, David S Albers, W Daniel Stamer
Purpose: To evaluate the relationship between the IOP-lowering effect of trabodenoson and the associated structural and functional changes in the trabecular meshwork (TM). Methods: Six independent cohorts of young and aged mice were exposed to three different topical once-a-day formulations of trabodenoson and eyes were compared to those treated with placebo drops. IOP was measured daily just before drug administration using rebound tonometry. Outflow facility was measured in enucleated eyes...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29346531/doppler-assessment-of-aortic-stenosis-a-25-operator-study-demonstrating-why-reading-the-peak-velocity-is-superior-to-velocity-time-integral
#2
Stefania Sacchi, Niti M Dhutia, Matthew J Shun-Shin, Massoud Zolgharni, Nilesh Sutaria, Darrel P Francis, Graham D Cole
Aims: Measurements with superior reproducibility are useful clinically and research purposes. Previous reproducibility studies of Doppler assessment of aortic stenosis (AS) have compared only a pair of observers and have not explored the mechanism by which disagreement between operators occurs. Using custom-designed software which stored operators' traces, we investigated the reproducibility of peak and velocity time integral (VTI) measurements across a much larger group of operators and explored the mechanisms by which disagreement arose...
January 15, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29345199/pulmonary-vascular-dysfunction-secondary-to-pulmonary-arterial-hypertension-insights-gained-through-retrograde-perfusion
#3
Chun Zhou, Edward S Crockett, Lynn Batten, Ivan F McMurtry, Troy Stevens
Here, we tested the hypothesis that severe pulmonary arterial hypertension impairs retrograde perfusion. To test this hypothesis, pulmonary arterial hypertension was induced in Fischer rats using a single injection of Sugen 5416 followed by 3 weeks of exposure to 10% hypoxia and then 2 weeks of normoxia. This Sugen 5416 and hypoxia regimen caused severe pulmonary arterial hypertension, with a Fulton Index of 0.73+0.07, reductions in both the pulmonary arterial acceleration time and pulmonary arterial acceleration to pulmonary arterial ejection times ratio, and extensive medial hypertrophy and occlusive neointimal lesions...
January 18, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29343297/pulmonary-valve-replacement-after-right-ventricular-outflow-tract-reconstruction-with-homograft-vs-contegra%C3%A2-a-case-control-comparison-of-mortality-and-morbidity
#4
Nicolas Poinot, Jean-Francois Fils, Hélène Demanet, Hugues Dessy, Dominique Biarent, Pierre Wauthy
BACKGROUND: Repair of congenital heart defects involving the right ventricular outflow tract may require the implantation of a right ventricle to pulmonary artery conduit. This conduit is likely to be replaced during childhood. This study compares the operative outcomes of the replacement procedure of Contegra® and homografts in pulmonary position. METHODS: From 1999 to 2016, 82 children underwent 87 right ventricle to pulmonary artery conduit replacements (60 Contegra® and 27 homografts)...
January 17, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29342992/-radiofrequency-catheter-ablation-of-premature-ventricular-contractions-in-children-under-carto3-system-a-retrospective-study-from-one-single-center
#5
W Ji, J J Wu, Y J Qian, Y W Chen, L J Fu, J Shen, F Li
Objective: To evaluate the clinical effect and summarize the experience of radiofrequency catheter ablation (RFCA) for children suffered from premature ventricular contractions (PVCs). Methods: This retrospective study was conducted by descriptive analysis. A total of 108 cases with frequent PVCs from Shanghai Children's Medical Center were treated with RFCA under the guidance of CARTO3 system from January 2011 to December 2016. The immediate success rate of the procedure, the recurrence rate and the perioperative complications were summarized...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29340864/analysis-of-accumulation-formation-of-sediment-contamination-in-reservoirs-after-decades-of-running-a-case-study-of-nitrogen-accumulation-in-biliuhe-reservoir
#6
Tianxiang Wang, Shiguo Xu, Jianwei Liu
Sediment contamination is an important influencing factor for reservoir water quality. Investigations have shown that reservoirs are facing the risk of sediment contamination after running for several decades in China. This paper proposes that the accumulation of sediment contaminant is resulted from the difference between the input and output of contaminant. Further, an accumulation model of reservoir sediment nitrogen is established based on this theory. The calculation result of Biliuhe Reservoir shows that inflow rate of total nitrogen into the reservoir is 4521...
January 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29340639/biomechanical-rigidity-and-quantitative-proteomics-analysis-of-segmental-regions-of-the-trabecular-meshwork-at-physiologic-and-elevated-pressures
#7
Janice A Vranka, Julia A Staverosky, Ashok P Reddy, Phillip A Wilmarth, Larry L David, Ted S Acott, Paul Russell, Vijay Krishna Raghunathan
Purpose: The extracellular matrix (ECM) of the trabecular meshwork (TM) modulates resistance to aqueous humor outflow, thereby regulating IOP. Glaucoma, a leading cause of irreversible blindness worldwide, is associated with changes in the ECM of the TM. The elastic modulus of glaucomatous TM is larger than age-matched normal TM; however, the biomechanical properties of segmental low (LF) and high flow (HF) TM regions and their response to elevated pressure, are unknown. Methods: We perfused human anterior segments at two pressures using an ex vivo organ culture system...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29340275/timing-of-transjugular-intrahepatic-portosystemic-shunt-for-budd-chiari-syndrome-an-italian-hepatologist-s-perspective
#8
Andrea Mancuso
Budd-Chiari syndrome (BCS) management flow-chart is derived from experts' opinion and is not evidence-based. Guidelines suggest BCS management should follow a stepwise strategy: medical therapy as first-line treatment, revascularization or transjugular intrahepatic portosystemic shunt (TIPS) if no response to medical therapy, and liver transplant as rescue therapy. Recent evidence suggests that only medical therapy results in a bad long-term outcome. The biggest criticism of guidelines is the indication that BCS should receive further treatment only when hemodynamic consequences of portal hypertension become clinically evident...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29339957/a-case-of-synchronised-pupillary-and-nasal-cycling-evidence-for-a-central-autonomic-pendulum
#9
Fion D Bremner, Jonas Gälldin Nordström
We previously reported that some healthy individuals show alternating anisocoria. We now describe one such individual who also exhibits a classic nasal cycle (alternating periods of nasal congestion and decongestion). We made measurements of his pupil asymmetry and nasal asymmetry at 21 different time points and found that these variables were always synchronised such that greater nasal airflow was invariably found on the same side as the larger pupil. We hypothesise that a common central oscillator may be responsible for co-modulating the sympathetic outflow to both nasal vessels and iris dilator muscles in some healthy individuals...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339763/glucocorticoid-receptor-gr%C3%AE-regulates-glucocorticoid-induced-ocular-hypertension-in-mice
#10
Gaurang C Patel, Yang Liu, J Cameron Millar, Abbot F Clark
Prolonged glucocorticoid (GC) therapy can cause GC-induced ocular hypertension (OHT), which if left untreated progresses to iatrogenic glaucoma and permanent vision loss. The alternatively spliced isoform of glucocorticoid receptor GRβ acts as dominant negative regulator of GR activity, and it has been shown that overexpressing GRβ in trabecular meshwork (TM) cells inhibits GC-induced glaucomatous damage in TM cells. The purpose of this study was to use viral vectors to selectively overexpress the GRβ isoform in the TM of mouse eyes treated with GCs, to precisely dissect the role of GRβ in regulating steroid responsiveness...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339601/ammonium-removal-in-landfill-leachate-using-sbr-technology-dispersed-versus-attached-biomass
#11
A Sivic, N Atanasova, S Puig, T Griessler Bulc
Large concentrations and oscillations of ammonium nitrogen (NH4+-N) in municipal landfill leachate pose considerable constraints to its further treatment in central wastewater treatment plants. The aim of this study was to evaluate and optimize two technologies for the pre-treatment of 600 L/day of landfill leachate: in particular, to optimize their operational conditions for NH4+-N removal up to a level appropriate for discharge to sewers, i.e. <200 mg/L. Both technologies were based on a sequencing batch reactor (SBR), with two different biomass processes: (A) SBR with dispersed/flocculated biomass and (B) SBR with biomass attached to carriers...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29336395/tricuspid-valve-straddling-an-uncommon-cause-of-left-ventricular-outflow-tract-obstruction-in-transposition-of-great-artery-with-ventricular-septal-defect
#12
Bhupesh Kumar, Aveek Jayant, Ganesh Kumar Munirathinam, Sachin Mahajan
Transposition of great arteries (TGA) can be associated with left ventricle outflow tract (LVOT) obstruction. In the presence of ventricular septal defect (VSD), septal leaflet of tricuspid valve may prolapse through perimembranous VSD or rarely tricuspid valve tissue may override to produce LVOT obstruction. Occasionally, this may be mistaken for vegetation due to associated pulmonary valve endocarditis. We report a case of d-TGA with presumptive pulmonary valve endocarditis and LVOT obstruction that was found to be due to tricuspid valve straddling on transesophageal echocardiography, resulting in change in the surgical plan and thus avoiding catastrophe...
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29335254/depressed-left-and-right-ventricular-cardiac-output-in-fetuses-of-diabetic-mothers
#13
Jennifer Winter, Aparna Kulkarni, Mary Craft, Ling Li, Lisa Hornberger, David A Danford, Shelby Kutty
INTRODUCTION: We compared right and left ventricular cardiac output (RVCO and LVCO) in fetuses of diabetic mothers (FDM) to a large normal cohort. METHODS: We prospectively enrolled 264 normal fetuses and 30 FDM. Fetal CO parameters: semilunar valve velocity time integrals (AVVTI, PVVTI), ventricular outflow diameters (LVOTD, RVOTD), stroke volumes (AVSV, PVSV) were measured, and LVCO and RVCO calculated.  These were normalized using nonlinear regression to estimated fetal weight (EFW) to provide means and standard deviations...
January 15, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29334487/a-novel-hinged-scleral-patch-graft-for-the-repair-of-overfiltration-and-bleb-leaks
#14
Pierre G Mardelli, Marc E Mardelli, Zeina Bakkour
INTRODUCTION: The repair of the scleral flap is often needed in cases of severe hypotony or bleb leaks with over filtration. We present a simple novel technique to restore the hinged flap using a scleral patch graft. MATERIALS AND METHODS: We present 4 eyes of 4 patients that present with hypotony (IOP <6▒mm Hg) from overfiltration secondary to loose scleral flap (2 eyes) and bleb leak (2 eyes). A scleral patch from human donor preserved in 95% ehtanol is cut in a trapezoidal shape and placed over the area of filtration after a conjunctival peritomy...
January 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29334157/elevated-sympathetic-vasomotor-outflow-in-response-to-increased-inspiratory-muscle-activity-during-exercise-is-less-in-young-women-compared-with-men
#15
Keisho Katayama, Joshua R Smith, Kanako Goto, Kaori Shimizu, Mitsuru Saito, Koji Ishida, Teruhiko Koike, Satoshi Iwase, Craig A Harms
We compared changes in muscle sympathetic nerve activity (MSNA) and cardiovascular variables during leg cycle exercise with increased inspiratory muscle resistance in men and women. We hypothesized that sympathetic vasomotor outflow during exercise with increased inspiratory resistance would be attenuated in young women compared with age-matched men. Eight women and seven men completed the study. The subjects performed two 10-min exercise bouts at 40% peak oxygen uptake using a cycle ergometer in a semirecumbent position [spontaneous breathing for 5 min and voluntary hyperventilation with or without inspiratory resistive breathing for 5 min (breathing frequency: 50 breaths min-1 with a 50% duty cycle, inspiratory resistance: 30% of maximal inspiratory pressure)]...
January 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29332907/patients-characteristics-and-clinical-course-of-hypertrophic-cardiomyopathy-in-a-regional-japanese-cohort%C3%A3-results-from-kochi-ryoma-study
#16
Toru Kubo, Takayoshi Hirota, Yuichi Baba, Yuri Ochi, Asa Takahashi, Naohito Yamasaki, Naohisa Hamashige, Katsuhito Yamamoto, Fumiaki Kondo, Kanji Bando, Eisuke Yamada, Takashi Furuno, Toshikazu Yabe, Yoshinori L Doi, Hiroaki Kitaoka
BACKGROUND: There have been few studies on the clinical course of hypertrophic cardiomyopathy (HCM) in a community-based patient cohort in Japan.Methods and Results:In 2004, we established a cardiomyopathy registration network in Kochi Prefecture (the Kochi RYOMA study) that consisted of 9 hospitals, and finally, 293 patients with HCM were followed. The ages at registration and at diagnosis were 63±14 and 56±16 years, respectively, and 197 patients (67%) were male. HCM-related deaths occurred in 23 patients during a mean follow-up period of 6...
January 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29327439/the-hidden-concealed-left-sided-accessory-pathway-an-uncommon-cause-of-svt-in-young-people
#17
Robert H Pass, Leonardo Liberman, Eric S Silver, Christopher M Janson, Andrew D Blaufox, Lynn Nappo, Scott R Ceresnak
BACKGROUND: Concealed left sided accessory pathways (CLAP) are a cause of SVT in the young. Most are mapped with RV apical/outflow pacing. Rarely, alternative means of mapping are required. We review our experience from 3 pediatric EP centers with a rare form of "hidden" CLAP. METHODS: All patients < 21 years undergoing EP study from 2008-2014 with a "hidden" CLAP (defined as an accessory pathway (AP) for which RV pacing at CL's stable for mapping did not demonstrate eccentric retrograde conduction) were included...
January 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29327146/mid-term-outcome-of-100-consecutive-ross-procedures-excellent-survival-but-yet-to-be-a-cure
#18
Corina Zimmermann, Christine Attenhofer Jost, René Prêtre, Christoph Mueller, Matthias Greutmann, Burkhardt Seifert, Emanuela Valsangiacomo Büchel, Oliver Kretschmar, Hitendu Hasmukhlal Dave, Roland Weber
The Ross procedure offers excellent short-term outcome but the long-term durability is under debate. Reinterventions and follow-up of 100 consecutive patients undergoing Ross Procedure at our centre (1993-2011) were analysed. Follow-up was available for 96 patients (97%) with a median duration of 5.3 (0.1-17.1) years. Median age of the patient cohort was 15.2 (0.04-58.4) years with 76 males. 93% had underlying congenital aortic stenosis. Root replacement technique was applied in all. The most common valved conduits used for reconstruction of the right ventricular outflow tract were homografts (66 patients) and bovine jugular vein (ContegraR) graft (31 patients)...
January 12, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29326778/-double-ball-valve-mechanism-obstructing-both-right-ventricular-inflow-and-outflow-atypical-presentation-of-right-atrial-myxoma-presenting-as-right-ventricular-mass
#19
Tarun Kumar, Satyam Rajvanshi, Ajay Kumar Sharma, Neeraj Pandit
Large intracavitary masses such as those occupying most of a cardiac chamber and obstructing blood flow are not routinely encountered in clinical practice. The differential diagnosis includes neoplastic as well as nonneoplastic causes. Primary cardiac tumors by themselves are uncommon. We hereby report a rare case of a middle-aged female presenting with New York Heart Association Class III symptoms, whose transthoracic echocardiogram revealed a huge mass in right-sided chambers with a novel double ball valve type movement...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29326128/idiopathic-ventricular-arrhythmias-originating-from-the-vicinity-of-the-communicating-vein-of-cardiac-venous-systems-at-the-left-ventricular-summit
#20
Yuki Komatsu, Akihiko Nogami, Yasutoshi Shinoda, Keita Masuda, Takeshi Machino, Kenji Kuroki, Hiro Yamasaki, Yukio Sekiguchi, Kazutaka Aonuma
BACKGROUND: The communicating vein (CV) between the great cardiac vein and small cardiac venous systems passes between the aortic and pulmonary annulus and is located in close association with the left ventricular summit (summit CV). METHODS AND RESULTS: Thirty-one patients with idiopathic ventricular arrhythmias (VAs) underwent mapping of the left ventricular summit by using a 2F microcatheter introduced into the summit CV with coronary sinus venographic guidance...
January 2018: Circulation. Arrhythmia and Electrophysiology
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