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Pediatric neuropsychology

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https://www.readbyqxmd.com/read/29573759/executive-dysfunction-and-depression-in-pediatric-temporal-lobe-epilepsy-the-contribution-of-hippocampal-sclerosis-and-psychosocial-factors
#1
William A Schraegle, Nancy L Nussbaum, Jeffrey B Titus
OBJECTIVES: Temporal lobe epilepsy (TLE) has been identified as a risk factor for increased depression features in children and adolescents; however, less is known regarding specific neurocognitive predictors of depression in this population above and beyond seizure-specific and sociodemographic factors. METHODS: The study included 62 patients with TLE (64% male) aged 8 to 16 years (M=12.62; SD=2.26) who underwent comprehensive neuropsychological evaluation. RESULTS: Correlation analyses revealed significant association between patient depression and WCST Total Perseverations, BRIEF Behavioral Regulation Index (BRI) and family stress...
March 25, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29556858/cyclic-vomiting-syndrome-in-children
#2
REVIEW
Anne Donnet, Sylvain Redon
PURPOSE OF REVIEW: Cyclic vomiting syndrome (CVS) is a misrecognized and probably underdiagnosed episodic syndrome associated with migraine, occurring preferentially in childhood. Attacks are stereotyped for each individual, with predictable periodicity. This review summarizes recent clinical and paraclinical observations in this syndrome, and current approaches in explorations and therapeutics. RECENT FINDINGS: Clinical phenotype during prodromal, vomiting, and recovery phases contains visceral and neuropsychological symptoms, but also cranial and systemic symptoms...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29521858/the-association-of-premorbid-neuropsychological-conditions-with-pediatric-mild-traumatic-brain-injury-concussion-recovery-time-and-symptom-severity-a-systematic-review-protocol
#3
Michelle Borzik Goreth, Michelle Palokas
The question of this review is: What is the association of premorbid neuropsychological conditions with mild traumatic brain injury/concussion recovery time and symptom severity in children?
March 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29510770/a-neuropsychological-profile-for-agenesis-of-the-corpus-callosum-cognitive-academic-executive-social-and-behavioral-functioning-in-school-age-children
#4
Vanessa Siffredi, Vicki Anderson, Alissandra McIlroy, Amanda G Wood, Richard J Leventer, Megan M Spencer-Smith
OBJECTIVES: Agenesis of the corpus callosum (AgCC), characterized by developmental absence of the corpus callosum, is one of the most common congenital brain malformations. To date, there are limited data on the neuropsychological consequences of AgCC and factors that modulate different outcomes, especially in children. This study aimed to describe general intellectual, academic, executive, social and behavioral functioning in a cohort of school-aged children presenting for clinical services to a hospital and diagnosed with AgCC...
March 7, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29488075/surgical-management-of-colloid-cysts-in-children-experience-at-a-tertiary-care-center
#5
Vikas Vazhayil, Nishanth Sadashiva, Nithish Nayak, A R Prabhuraj, Dhaval Shukla, Sampath Somanna
INTRODUCTION: Colloid cysts are uncommon lesions in the pediatric age group, which most commonly occur in the fourth through fifth decades. The authors hereby report a series of 36 patients with colloid cysts in the pediatric age group. MATERIAL AND METHOD: A retrospective chart review was conducted on all patients with colloid cyst who underwent surgery in our institute between November 2003 and December 2016 (13 years). Patients above the age of 18 were excluded from the study...
February 27, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29414546/unique-and-shared-areas-of-cognitive-function-in-children-with-intractable-frontal-or-temporal-lobe-epilepsy
#6
Nicole Law, Elysa Widjaja, Mary Lou Smith
OBJECTIVE: Previous findings have been mixed in terms of identifying a distinct pattern of neuropsychological deficits in children with frontal lobe epilepsy (FLE) and in those with temporal lobe epilepsy (TLE). The current study investigated the neuropsychological similarities and differences across these two pediatric medically intractable localization-related epilepsies. METHOD: Thirty-eight children with FLE, 20 children with TLE, and 40 healthy children (HC) participated in this study...
January 25, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29411414/whole-genome-association-study-of-brain-wide-imaging-phenotypes-a-study-of-the-ping-cohort
#7
Canhong Wen, Chintan M Mehta, Haizhu Tan, Heping Zhang
Neuropsychological disorders have a biological basis rooted in brain function, and neuroimaging data are expected to better illuminate the complex genetic basis of neuropsychological disorders. Because they are biological measures, neuroimaging data avoid biases arising from clinical diagnostic criteria that are subject to human understanding and interpretation. A challenge with analyzing neuroimaging data is their high dimensionality and complex spatial relationships. To tackle this challenge, we introduced a novel distance covariance tests that can assess the association between genetic markers and multivariate diffusion tensor imaging measurements, and analyzed a genome-wide association study (GWAS) dataset collected by the Pediatric Imaging, Neurocognition, and Genetics (PING) study...
February 7, 2018: Genetic Epidemiology
https://www.readbyqxmd.com/read/29385018/quantitative-volumetric-imaging-and-clinical-outcome-characterization-of-symptomatic-concussion-in-10-to-14-year-old-adolescent-athletes
#8
Christine L Mac Donald, Jason Barber, Jason Wright, David Coppel, Nina De Lacy, Steve Ottinger, Suzanne Peck, Chris Panks, Kody Zalewski, Samantha Sun, Nancy Temkin
OBJECTIVE: Prior work suggests that younger athletes may be more vulnerable to postconcussive syndrome. We investigated measures of clinical outcome and quantitative volumetric imaging in 10- to 14-year-old adolescent athletes to better understand the impact of concussion on this younger population. SETTING: Outpatient clinics. PARTICIPANTS: Ten- to 14-year-old symptomatic pediatric sports concussion patients and typically developing active controls...
January 30, 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29375005/everyday-executive-function-in-focal-onset-pediatric-epilepsy-on-the-parent-report-brief2
#9
Chelsea L Black, Sharon W Shih, Leigh N Sepeta, Joy M Facella-Ervolini, Peter K Isquith, Madison M Berl
Executive function (EF) difficulties are a core neuropsychological feature of pediatric epilepsy, and parent-report measures of EF concerns are an important complement to task-based EF measures. The Behavior Rating Inventory of Executive Function (BRIEF) has shown sensitivity to parent-reported EF concerns in epilepsy and other pediatric populations. We compared profiles of parent-reported EF concerns using the BRIEF and its revision, the BRIEF2, in 117 pediatric patients with focal onset epilepsy to examine the clinical utility of the revised scale...
January 29, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29373161/quantitative-microstructural-cerebral-changes-in-neurofibromatosis-type-1
#10
Eva Bültmann, Loukia M Spineli, Hans Hartmann, Annette Sander, Heinrich Lanfermann
OBJECTIVES: To evaluate microstructural cerebral changes in children with neurofibromatosis type 1 (NF1) based on T2 relaxation time measurements at 3Tesla. METHODS: From our dataset of pediatric MRI examinations at 3T 19 pediatric NF1 patients (1.9-14.3 years of age, 9 girls, 10 boys) were retrospectively selected and compared with the previously published group of 44 healthy children (0-16 years of age). MRI examination included a triple echo TSE sequence as basis for T2 maps...
January 17, 2018: Brain & Development
https://www.readbyqxmd.com/read/29329164/a-systematic-review-of-risk-factors-associated-with-cognitive-impairment-after-pediatric-critical-illness
#11
Alicia G Kachmar, Sharon Y Irving, Cynthia A Connolly, Martha A Q Curley
OBJECTIVES: To identify risk factors associated with cognitive impairment as assessed by neuropsychologic tests in neurotypical children after critical illness. DATA SOURCES: For this systematic review, we searched the Cochrane Library, Scopus, PubMed, Ovid, Embase, and CINAHL databases from January 1960 to March 2017. STUDY SELECTION: Included were studies with subjects 3-18 years old at the time of post PICU follow-up evaluation and use of an objective standardized neuropsychologic test with at least one cognitive functioning dimension...
March 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29324745/proof-of-concept-study-of-an-at-home-engaging-digital-intervention-for-pediatric-adhd
#12
Naomi O Davis, Jeffrey Bower, Scott H Kollins
OBJECTIVE: Pharmacological and behavioral therapies have limited impact on the distinct neurocognitive impairments associated with ADHD, and existing cognitive training programs have shown limited efficacy. This proof-of-concept study assessed treatment acceptability and explored outcomes for a novel digital treatment targeting cognitive processes implicated in ADHD. METHOD: Participants included 40 children with ADHD and 40 children without ADHD. Following psychiatric screening, ADHD ratings, and baseline neuropsychological measures, participants completed 28-days of at-home treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29298678/the-brainfit-study-efficacy-of-cognitive-training-and-exergaming-in-pediatric-cancer-survivors-a-randomized-controlled-trial
#13
Valentin Benzing, Noëmi Eggenberger, Janine Spitzhüttl, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Theda Heinks, Mirko Schmidt, Achim Conzelmann, Maja Steinlin, Regula Everts, Kurt Leibundgut
BACKGROUND: Cancer survival comes at a price: pediatric cancer survivors bear a high risk for a wide range of cognitive difficulties. Therefore, interventions targeting these difficulties are required. The aim of the present clinical trial is to extend empirical evidence about efficacy of cognitive and physical training in pediatric cancer survivors. It is hypothesized that early cognitive and physical interventions affect the remediation of pediatric cancer survivors in terms of improved executive functions (primary outcome)...
January 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29249552/pretreatment-cognition-in-patients-diagnosed-with-pediatric-brain-tumors
#14
Elin Irestorm, Sean Perrin, Ingrid Tonning Olsson
BACKGROUND: There is a large body of literature identifying risk factors for the long-term cognitive alterations found in survivors of pediatric brain tumors. Less is known about baseline cognitive functioning in this population, but studies suggest that cognitive dysfunctions are often present at the time of diagnosis. This study aimed to identify potential risk factors for lower cognitive function at the time of pediatric brain tumor diagnosis. METHODS: Participants were children and adolescents (n = 101) diagnosed with a pediatric brain tumor between 2006 and 2015, who underwent a pretreatment neuropsychologic assessment...
February 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29249507/neurocognitive-comorbidities-in-pediatric-epilepsy-lessons-in-the-laboratory-and-clinical-profile
#15
Lily H Tran, Mary L Zupanc
Children with epilepsy are at risk for a variety of neurocognitive comorbidities. Animal models have increased our understanding about the neurobiological mechanisms underlying the association between seizures and these comorbidities. This article starts with an overview of the current data on animal model research, studying the influence of early-life seizures, followed by a summary of potential cellular and molecular mechanisms by which seizures can affect cognitive development. We then describe specific abnormal neuropsychological profiles that accompany specific pediatric epilepsy syndromes...
November 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29243544/communication-is-key-the-utility-of-a-revised-neuropsychological-report-format
#16
Katherine T Baum, Christian von Thomsen, Megan Elam, Christel Murphy, Melissa Gerstle, Cynthia A Austin, Dean W Beebe
OBJECTIVE: The neuropsychological report is a critical tool for communicating evaluation results to multiple audiences who have varying knowledge about neuropsychology and often have limited ability to review long, complex reports. Considerable time is spent writing these reports and challenges persist related to readability, length/complexity, and billable clinical time (which may be capped by third-party payors or families' ability to pay). METHODS: This quality improvement effort systematically evaluated the redesign of pediatric neuropsychological reports in an outpatient clinic serving primarily medical populations...
April 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29214403/executive-functioning-academic-skills-and-quality-of-life-in-pediatric-patients-with-brain-tumors-post-proton-radiation-therapy
#17
Lea M Ventura, Julie A Grieco, Casey L Evans, Karen A Kuhlthau, Shannon M MacDonald, Nancy J Tarbell, Torunn I Yock, Margaret B Pulsifer
Radiation therapy (RT) is integral in the treatment of pediatric brain tumors; however, photon RT (XRT) often results in intellectual decline, executive functioning (EF) deficits, academic underachievement/failure, and lower health-related quality of life (HRQoL). Proton RT (PRT) provides more targeted therapy, minimizing damage to the developing brain, yet few studies have examined its neuropsychological effects. This study investigated the role of EF in academic skills and HRQoL in a sample of children treated with PRT...
March 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29204198/profile-and-outcome-of-pediatric-brain-tumors-experience-from-a-tertiary-care-pediatric-oncology-unit-in-south-india
#18
Supriya Gujjar Suresh, Arathi Srinivasan, Julius Xavier Scott, Santosh Mohan Rao, Balasubramaniam Chidambaram, Sanjay Chandrasekar
Context: Tumors of the central nervous system (CNS) constitute the second most common pediatric cancers. Unlike leukemia, management of CNS tumors requires a good multidisciplinary team. Higher rates of treatment abandonment are documented in view of complexity of the treatment with long duration, involving neurosurgery, radiation, chemotherapy, and high cost of treatment. Morbidity associated with CNS tumors may be significant in terms of physical deficits as well as neuropsychological and neuroendocrine sequelae...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29200184/structural-neuroimaging-and-neuropsychologic-signatures-of-vertically-acquired-hiv
#19
Robert Paul, Wasana Prasitsuebsai, Neda Jahanashad, Thanyawee Puthanakit, Paul Thompson, Linda Aurpibul, Rawiwan Hansudewechakul, Pope Kosalaraksa, Suparat Kanjanavanit, Chaiwat Ngampiyaskul, Wicharn Luesomboon, Sukalaya Lerdlum, Mantana Pothisri, Pannee Visrutaratna, Victor Valcour, Talia M Nir, Arvin Saremi, Stephen Kerr, Jintanat Ananworanich
BACKGROUND: Children with vertically acquired human immunodeficiency virus (HIV) exhibit persistent cognitive impairments, yet the corresponding neuroimaging signature of vertical infection remains unclear. METHODS: Fifty healthy control children and 51 vertically infected children were included in the study. The HIV-infected group consisted of survivors who had not received antiretroviral therapy (ART) at birth. The HIV-infected group averaged 11.4 (2.5) years of age, with a median CD4 count of 683 cells/mm...
December 1, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29198279/neuropsychology-of-multiple-sclerosis-looking-back-and-moving-forward
#20
Ralph H B Benedict, John DeLuca, Christian Enzinger, Jeroen J G Geurts, Lauren B Krupp, Stephen M Rao
The neuropsychological aspects of multiple sclerosis (MS) have evolved over the past three decades. What was once thought to be a rare occurrence, cognitive dysfunction is now viewed as one of the most disabling symptoms of the disease, with devastating effects on patients' quality of life. This selective review will highlight major innovations and scientific discoveries in the areas of neuropathology, neuroimaging, diagnosis, and treatment that pertain to our understanding of the neuropsychological aspects of MS...
October 2017: Journal of the International Neuropsychological Society: JINS
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