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Pediatric neuropsychology

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https://www.readbyqxmd.com/read/29893273/estimated-iq-systematically-underestimates-neurocognitive-sequelae-in-irradiated-pediatric-brain-tumor-survivors
#1
Laura Burgess, Margaret B Pulsifer, Julie A Grieco, Elliott R Weinstein, Sara Gallotto, Elizabeth Weyman, Shannon M MacDonald, Nancy J Tarbell, Beow Y Yeap, Torunn I Yock
PURPOSE: While cranial irradiation is often essential to attain a cure for pediatric brain tumors, it is associated with adverse neurocognitive outcomes, primarily manifested as declines in full-scale IQ (FSIQ). This decline results primarily from a decline in processing speed, a component of FSIQ. However, estimated IQ (EIQ) is frequently used in research and clinical settings but does not incorporate processing speed. We hypothesized that EIQ systematically underestimates neurocognitive sequelae in irradiated pediatric brain tumor survivors...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29884144/computer-assisted-rehabilitation-of-attention-in-pediatric-multiple-sclerosis-and-adhd-patients-a-pilot-trial
#2
Marta Simone, Rosa Gemma Viterbo, Lucia Margari, Pietro Iaffaldano
BACKGROUND: The treatment of cognitive deficits is challenging in pediatric onset multiple sclerosis (POMS) and in patients with attention deficit hyperactivity disorder (ADHD). We performed a pilot double-blind RCT to evaluate the efficacy of a home-based computerized-program for retraining attention in two cohorts of POMS and ADHD patients. METHODS: POMS and ADHD patients failing in at least 2/4 attention tests on a neuropsychological battery were randomized to specific or nonspecific computerized training (ST, nST), performed in one-hour sessions, twice/week for 3 months...
June 8, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29883682/regional-brain-tissue-integrity-in-pediatric-obstructive-sleep-apnea
#3
Leila Kheirandish-Gozal, Ashish K Sahib, Paul M Macey, Mona F Philby, David Gozal, Rajesh Kumar
Children with long-standing obstructive sleep apnea (OSA) show evidence of neural injury and functional deficits in behavioral and cognitive regulatory brain regions that are reflected in symptoms of altered cognitive performance and behaviors. While we earlier showed reduced gray matter volume and increased and reduced regional cortical thicknesses, such structural changes give little indication of the underlying pathology. Brain tissue integrity in pediatric OSA subjects can reflect the nature and extent of injury or structural adaptation, and can be assessed by entropy tissue texture, a measure of local changes in signal intensity patterns from high-resolution magnetic resonance images...
June 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29873604/a-new-kid-on-the-block-the-memory-validity-profile-mvp-in-children-with-neurological-conditions
#4
Brian L Brooks, Taryn B Fay-McClymont, William S MacAllister, Marsha Vasserman, Elisabeth M S Sherman
Determining the validity of obtained data is an inherent part of a neuropsychological assessment. The purpose of this study was investigate the failure rate of the Memory Validity Profile (MVP) in a large clinical sample of children and adolescents with neurological diagnoses. Data were obtained from 261 consecutive patients (mean age = 12.0, SD = 3.9, range = 5-19) who were referred for a neuropsychological assessment in a tertiary care pediatric hospital and were administered the MVP. In this sample, 4...
June 6, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29846679/neuropsychological-functioning-of-youth-receiving-intensive-interdisciplinary-pain-treatment
#5
Christina M Low Kapalu, John J Hall, Dustin P Wallace
Objective: Chronic pain is associated with school difficulties; however, there is limited published evidence on the cognitive or neuropsychological functioning of youth with chronic pain. Method: When beginning intensive interdisciplinary pain treatment, 94 youth (age = 10-18) with chronic pain completed neuropsychological assessment (e.g., intelligence, academic skills, learning and recall, and attention) and clinical questionnaires (e.g., pain and physical and psychological functioning)...
May 25, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29809036/predictors-of-neuropsychological-outcome-after-pediatric-concussion
#6
Miriam H Beauchamp, Mary Aglipay, Keith Owen Yeates, Naddley Désiré, Michelle Keightley, Peter Anderson, Brian L Brooks, Nick Barrowman, Jocelyn Gravel, Kathy Boutis, Isabelle Gagnon, Alexander Sasha Dubrovsky, Roger Zemek
OBJECTIVE: Previous research suggests that neuropsychological outcome after pediatric concussion is determined by unmodifiable, preexisting factors. This study aimed to predict neuropsychological outcome after pediatric concussion by using a sufficiently large sample to explore a vast array of predictors. METHOD: A total of 311 children and adolescents (6-18 years old) with concussion were assessed in the emergency department to document acute symptomatology and to screen for cognitive functioning...
May 2018: Neuropsychology
https://www.readbyqxmd.com/read/29797640/divergt-screening-procedure-predicts-general-cognitive-functioning-in-adult-long-term-survivors-of-pediatric-acute-lymphoblastic-leukemia-a-petale-study
#7
Aubree Boulet-Craig, Philippe Robaey, Julie Laniel, Laurence Bertout, Simon Drouin, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Serge Sultan, Sarah Lippé
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Because of major improvements in treatment protocols, the survival rate now exceeds 80%. However, ALL treatments can cause long-term neurocognitive sequelae, which negatively impact academic achievement and quality of life. Therefore, cognitive sequelae need to be carefully evaluated. The DIVERGT is a battery of tests proposed as a screening tool, sensitive to executive function impairments in children and adolescent cancer survivors...
May 24, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29741397/preliminary-normative-data-on-the-borb-for-children-aged-3-8
#8
Ruth Brunsdon, Pamela Joy, Erin Patten, Karen Burton
The Birmingham Object Recognition Battery (BORB) is a theoretically based test battery that is used in adult cognitive neuropsychology in research and for clinical assessment. It allows a detailed analysis of underlying impairments in individuals with brain injury who have visual object recognition difficulties. The BORB's usefulness in pediatrics is supported by numerous research studies. However, there is no published normative data for children, making clinical use of the test difficult. The aim of this brief report is to publish some preliminary normative data in 70 children aged between 3 and 8 years to assist both researchers and clinicians with interpretation of test scores...
May 9, 2018: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29739276/corpus-callosum-vasculature-predicts-white-matter-microstructure-abnormalities-following-pediatric-mild-traumatic-brain-injury
#9
Kara M Wendel, Jeong Bin Lee, Bethann Affeldt, Mary Hamer, Indira S Harahap-Carrillo, Andrea C Pardo, Andre Obenaus
Emerging data suggest that pediatric traumatic brain injury (TBI) is associated with impaired developmental plasticity and poorer neuropsychological outcomes than adults with similar head injuries. Unlike adult mild TBI (mTBI), the effects of mTBI on white matter (WM) microstructure and vascular supply are not well-understood in the pediatric population. The cerebral vasculature plays an important role providing necessary nutrients and removing waste. To address this critical element, we examined the microstructure of the corpus callosum (CC) following pediatric mTBI using diffusion tensor imaging (DTI), and investigated myelin, oligodendrocytes, and vasculature of WM with immunohistochemistry...
May 9, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29718853/pediatric-tuina-for-promoting-growth-and-development-of-preterm-infants-a-protocol-for-the-systematic-review-of-randomized-controlled-trail
#10
Xinghe Zhang, Taipin Guo, Bowen Zhu, Qing Gao, Hourong Wang, Xiantao Tai, Fujie Jing
BACKGROUND: Preterm infants are babies born alive before 37 weeks. Many survived infants concomitant with defects of growth and development, a lifetime of disability usually as following when insufficient intervention. In early intervention of preterm infants, pediatric Tuina shows good effect in many Chinese and some English clinical trials. This systematic review is aimed to evaluate the efficacy and safety of pediatric Tuina for promoting growth and development of preterm infants. METHODS: The electronic databases of Cochrane Library, MEDLINE, EBASE, Web of Science, Springer, World Health Organization International Clinical Trials Registry Platform, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wan-fang database, Chinese Scientific Journal Database, and other databases will be searched from establishment to April 1, 2018...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29705926/executive-functioning-heterogeneity-in-pediatric-adhd
#11
Michael J Kofler, Lauren N Irwin, Elia F Soto, Nicole B Groves, Sherelle L Harmon, Dustin E Sarver
Neurocognitive heterogeneity is increasingly recognized as a valid phenomenon in ADHD, with most estimates suggesting that executive dysfunction is present in only about 33%-50% of these children. However, recent critiques question the veracity of these estimates because our understanding of executive functioning in ADHD is based, in large part, on data from single tasks developed to detect gross neurological impairment rather than the specific executive processes hypothesized to underlie the ADHD phenotype...
April 28, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29703768/long-term-neuropsychological-outcome-following-pediatric-anti-nmdar-encephalitis
#12
Marienke A A M de Bruijn, Femke K Aarsen, Marielle P van Oosterhout, Marieke M van der Knoop, Coriene E Catsman-Berrevoets, Marco W J Schreurs, Danielle E M Bastiaansen, Peter A E Sillevis Smitt, Rinze F Neuteboom, Maarten J Titulaer
OBJECTIVE: To provide detailed long-term outcome data of children and adolescents following pediatric anti- N -methyl-d-aspartate receptor (anti-NMDAR) encephalitis, to identify neuropsychological impairments, and to evaluate the influence of these factors on quality of life (QoL). METHODS: All Dutch children diagnosed with anti-NMDAR encephalitis were identified. Patients currently aged 4 years or older were included in the follow-up study, consisting of a visit to our clinic for a detailed interview and a standardized neuropsychological assessment...
April 27, 2018: Neurology
https://www.readbyqxmd.com/read/29679197/neuropsychological-impacts-of-indirect-revascularization-for-pediatric-moyamoya-disease
#13
WooHyun Kim, Eun-Young Lee, Seong-Eun Park, Eun-Kyung Park, Ju-Seong Kim, Dong-Seok Kim, Kyu-Won Shim
PURPOSE: Moyamoya disease (MMD) commonly leads to neurocognitive impairment. This study was carried out to show that temporal encephaloduroarteriosynangiosis (EDAS) has a positive neuropsychological impact on pediatric MMD patients. METHODS: Fifty-five participants diagnosed with MMD from 2008 to 2014 were included in this retrospective study. The mean age at the preoperative evaluation was 9.5 years and the mean age at postoperative evaluation was 10.4. The average interval of initial and follow-up test was 10 months...
June 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29573759/executive-dysfunction-and-depression-in-pediatric-temporal-lobe-epilepsy-the-contribution-of-hippocampal-sclerosis-and-psychosocial-factors
#14
William A Schraegle, Nancy L Nussbaum, Jeffrey B Titus
OBJECTIVES: Temporal lobe epilepsy (TLE) has been identified as a risk factor for increased depression features in children and adolescents; however, less is known regarding specific neurocognitive predictors of depression in this population above and beyond seizure-specific and sociodemographic factors. METHODS: The study included 62 patients with TLE (64% male) aged 8 to 16 years (M=12.62; SD=2.26) who underwent comprehensive neuropsychological evaluation. RESULTS: Correlation analyses revealed significant association between patient depression and WCST Total Perseverations, BRIEF Behavioral Regulation Index (BRI) and family stress...
March 25, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29556858/cyclic-vomiting-syndrome-in-children
#15
REVIEW
Anne Donnet, Sylvain Redon
PURPOSE OF REVIEW: Cyclic vomiting syndrome (CVS) is a misrecognized and probably underdiagnosed episodic syndrome associated with migraine, occurring preferentially in childhood. Attacks are stereotyped for each individual, with predictable periodicity. This review summarizes recent clinical and paraclinical observations in this syndrome, and current approaches in explorations and therapeutics. RECENT FINDINGS: Clinical phenotype during prodromal, vomiting, and recovery phases contains visceral and neuropsychological symptoms, but also cranial and systemic symptoms...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29521858/the-association-of-premorbid-neuropsychological-conditions-with-pediatric-mild-traumatic-brain-injury-concussion-recovery-time-and-symptom-severity-a-systematic-review-protocol
#16
Michelle Borzik Goreth, Michelle Palokas
The question of this review is: What is the association of premorbid neuropsychological conditions with mild traumatic brain injury/concussion recovery time and symptom severity in children?
March 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29510770/a-neuropsychological-profile-for-agenesis-of-the-corpus-callosum-cognitive-academic-executive-social-and-behavioral-functioning-in-school-age-children
#17
Vanessa Siffredi, Vicki Anderson, Alissandra McIlroy, Amanda G Wood, Richard J Leventer, Megan M Spencer-Smith
OBJECTIVES: Agenesis of the corpus callosum (AgCC), characterized by developmental absence of the corpus callosum, is one of the most common congenital brain malformations. To date, there are limited data on the neuropsychological consequences of AgCC and factors that modulate different outcomes, especially in children. This study aimed to describe general intellectual, academic, executive, social and behavioral functioning in a cohort of school-aged children presenting for clinical services to a hospital and diagnosed with AgCC...
May 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29488075/surgical-management-of-colloid-cysts-in-children-experience-at-a-tertiary-care-center
#18
Vikas Vazhayil, Nishanth Sadashiva, Nithish Nayak, A R Prabhuraj, Dhaval Shukla, Sampath Somanna
INTRODUCTION: Colloid cysts are uncommon lesions in the pediatric age group, which most commonly occur in the fourth through fifth decades. The authors hereby report a series of 36 patients with colloid cysts in the pediatric age group. MATERIAL AND METHOD: A retrospective chart review was conducted on all patients with colloid cyst who underwent surgery in our institute between November 2003 and December 2016 (13 years). Patients above the age of 18 were excluded from the study...
February 27, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29414546/unique-and-shared-areas-of-cognitive-function-in-children-with-intractable-frontal-or-temporal-lobe-epilepsy
#19
Nicole Law, Elysa Widjaja, Mary Lou Smith
OBJECTIVE: Previous findings have been mixed in terms of identifying a distinct pattern of neuropsychological deficits in children with frontal lobe epilepsy (FLE) and in those with temporal lobe epilepsy (TLE). The current study investigated the neuropsychological similarities and differences across these two pediatric medically intractable localization-related epilepsies. METHOD: Thirty-eight children with FLE, 20 children with TLE, and 40 healthy children (HC) participated in this study...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29411414/whole-genome-association-study-of-brain-wide-imaging-phenotypes-a-study-of-the-ping-cohort
#20
Canhong Wen, Chintan M Mehta, Haizhu Tan, Heping Zhang
Neuropsychological disorders have a biological basis rooted in brain function, and neuroimaging data are expected to better illuminate the complex genetic basis of neuropsychological disorders. Because they are biological measures, neuroimaging data avoid biases arising from clinical diagnostic criteria that are subject to human understanding and interpretation. A challenge with analyzing neuroimaging data is their high dimensionality and complex spatial relationships. To tackle this challenge, we introduced a novel distance covariance tests that can assess the association between genetic markers and multivariate diffusion tensor imaging measurements, and analyzed a genome-wide association study (GWAS) dataset collected by the Pediatric Imaging, Neurocognition, and Genetics (PING) study...
April 2018: Genetic Epidemiology
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