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hepatitis B retrospective

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https://www.readbyqxmd.com/read/29779314/-impact-of-psoas-muscle-index-on-early-postoperative-mortality-and-complications-after-liver-transplantation
#1
J C Hou, H Zheng, Z Qiang, Y M Zhang, W T Jiang, W Gao, J Z Cai, J J Zhang, Z Y Shen
Objective: To investigate the relationship between psoas muscle index (PMI) and early postoperative survival rate and the incidence of complications after liver transplantation in adults. Methods: The clinical data of 225 patients (male, n =184; female, n =41) underwent liver transplantation at the Organ Transplantation Department of First Central Clinic Institute of Tianjin Medical University from January 2014 to December 2016 were analyzed, retrospectively.Original disease: hepatitis B liver cirrhosis(44 cases), hepatitis C cirrhosis(10 cases), autoimmune liver cirrhosis(29 cases), other benign liver diseases(24 cases), liver cirrhosis with liver cancer(116 cases), hilar cholangiocarcinoma(1 case) and hepatic vascular sarcoma(1 case)...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29779299/health-issues-of-refugees-attending-an-infectious-disease-refugee-health-clinic-in-a-regional-australian-hospital
#2
Peta J Masters, Penelope J Lanfranco, Emmy Sneath, Amanda J Wade, Sarah Huffam, James Pollard, James Standish, Kate McCloskey, Eugene Athan, Daniel P O'Brien, N Deborah Friedman
BACKGROUND AND OBJECTIVES: Refugees in Australia present with conditions different to those of the general population. The aim of this study was to review the reasons for referral, prevalence of conditions and treatment outcomes for refugee patients attending a specialist referral clinic in regional Victoria. METHOD: A retrospective review was undertaken of patients attending the refugee health clinic at University Hospital Geelong from January 2007 to December 2012...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29774155/is-de-novo-hepatocellular-carcinoma-after-transjugular-intrahepatic-portosystemic-shunt-increased
#3
A Hüsing-Kabar, T Meister, M Köhler, W Domschke, I Kabar, C Wilms, B Hild, H H Schmidt, H S Heinzow
Background: Portal hypertension is a major complication of liver cirrhosis. Transjugular intrahepatic portosystemic shunt is effective in treatment of portal hypertension. However, decreased parenchymal portal venous flow after transjugular intrahepatic portosystemic shunt insertion favours ischaemic liver injury which has been discussed to induce hepatocarcinogenesis causing hepatocellular cancer. Aim: This study aimed to explore the association between transjugular intrahepatic portosystemic shunt placement and the development of hepatocellular cancer...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29772892/risk-areas-for-hepatitis-a-b-and-c-in-the-municipality-of-maring%C3%A3-paran%C3%A3-state-brazil-2007-2010
#4
Valéria Miranda Avanzi, Udelysses Janete Veltrini Fonzar, Eraldo Schunk Silva, Jorge Juarez Vieira Teixeira, Dennis Armando Bertolini
Viral hepatitis is a major public health problem in Brazil and worldwide. We retrospectively analyzed 338 cases of hepatitis A, B and C in Maringá, Paraná State from 2007 through 2010. The hepatitis A virus was present in 5.6% of the cases, hepatitis B in 44.7% and hepatitis C in 49.7%. Most of the patients affected were male (55.3%), white (79.6%) and had some primary education (42.9%). Of the 338 cases analyzed, 13.0% had comorbidities. The cases were concentrated in large-population census zones, but it was concluded that the spatial distribution of viral hepatitis in Maringá occurred randomly rather than show any regular pattern...
May 8, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29764511/high-serum-levels-of-pregenomic-rna-reflect-frequently-failing-reverse-transcription-in-hepatitis-b-virus-particles
#5
Kasthuri Prakash, Gustaf E Rydell, Simon B Larsson, Maria Andersson, Gunnar Norkrans, Heléne Norder, Magnus Lindh
BACKGROUND: Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in serum of infected individuals, and quantification of this HBV RNA could be clinically useful. METHODS: In a retrospective study of 95 patients with chronic HBV infection, we characterised HBV RNA in serum in terms of concentration, particle association and sequence...
May 15, 2018: Virology Journal
https://www.readbyqxmd.com/read/29761585/hepatitis-b-virus-hbv-reactivation-the-potential-role-of-direct-acting-agents-for-hepatitis-c-virus-hcv
#6
REVIEW
Jason T Blackard, Kenneth E Sherman
Hepatitis C virus (HCV) is known to inhibit hepatitis B virus (HBV) replication in patients with HBV/HCV coinfection. Reactivation of HBV in patients treated for HCV with direct-acting agents (DAAs) has emerged recently as an important clinical consideration. A growing number of case reports and case series support the association between new HCV treatments and HBV reactivation. Yet, very little is known about the specific viral characteristics that facilitate reactivation as functional characterization of the reactivated HBV has been conducted only rarely...
May 15, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29758235/innovation-and-trends-in-the-development-and-approval-of-antiviral-medicines-1987-2017-and-beyond
#7
REVIEW
Shuvam Chaudhuri, Julian A Symons, Jerome Deval
2017 marked the 30th anniversary of the approval of zidovudine (AZT) as the first HIV/AIDS therapy. Since then, more than eighty antiviral drugs have received FDA approval, half of which treat HIV infection. Here, we provide a retrospective analysis of approved antiviral drugs, including therapeutics against other major chronic infections such as hepatitis B and C, and herpes viruses, over the last thirty years. During this time, only a few drugs were approved to treat acute viral infections, mainly influenza...
May 15, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29754851/treatment-of-hepatocellular-carcinoma-with-tumor-thrombus-with-the-use-of-iodine-125-seed-strand-implantation-and-transarterial-chemoembolization-a-propensity-score-analysis
#8
Zi-Han Zhang, Wen Zhang, Jun-Ying Gu, Qing-Xin Liu, Jing-Qin Ma, Ling-Xiao Liu, Jian-Hua Wang, Jian-Jun Luo, Zhi-Ping Yan
PURPOSE: To evaluate the safety and efficacy of iodine-125 (125 I) seed strand implantation in combination with transarterial chemoembolization for the treatment of hepatitis B-related unresectable hepatocellular carcinoma (HCC) with portal vein invasion. MATERIALS AND METHODS: From January 2013 to June 2016, 76 HCC patients with type II tumor thrombus were included in this single-center retrospective study. Twenty patients underwent 125 I seed strand implantation combined with transarterial chemoembolization (group A; n = 20), while 56 patients underwent transarterial chemoembolization alone (group B; n = 56)...
May 10, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29754328/hbsag-negative-and-anti-hbc-positive-in-eosinophilic-granulomatosis-with-polyangiitis-a-retrospective-pilot-study
#9
Sang-Won Lee, Do Young Kim, Sang Hoon Ahn, Yong-Beom Park, Kwang-Hyub Han, Jun Yong Park
We examined whether resolved hepatitis B virus (HBV) infection was associated with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and affected AAV activity at diagnosis and prognosis during the follow-up. We reviewed the electronic medical records of 153 AAV patients, and included 91 hepatitis B surface antigen (HBsAg)-negative patients having results of both antibody to hepatitis B core antigen (anti-HBc) and surface antigen (anti-HBs). We collected clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis and relapse rates during the follow-up...
May 12, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29753174/skeletal-muscle-fat-deposition-is-associated-with-hepatocellular-carcinoma-development-in-patients-with-chronic-liver-disease
#10
Yoshihiko Tachi, Akihiro Kozuka, Takanori Hirai, Yuko Kojima, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto
OBJECTIVES: The effect of skeletal muscle fat deposition on the prognosis of patients with chronic liver disease remains unclear. Skeletal muscle fat deposition can be estimated by attenuation of skeletal muscle in Hounsfield units (HU) on computed tomography (CT). The aim of this retrospective cohort study was to investigate the association between skeletal muscle fat deposition assessed by skeletal muscle attenuation (SMA), and hepatocellular carcinoma (HCC). METHODS: We enrolled 288 patients with chronic liver disease (139 men, 149 women; mean age 67...
March 21, 2018: Nutrition
https://www.readbyqxmd.com/read/29753083/level-of-hepatitis-b-hb-core-antibody-associates-with-seroclearance-of-hbv-dna-and-hb-surface-antigen-in-hb-e-antigen-seronegative-patients
#11
Hui-Han Hu, Jessica Liu, Chia-Ling Chang, Chin-Lan Jen, Mei-Hsuan Lee, Sheng-Nan Lu, Li-Yu Wang, Yuan Quan, Ning-Shao Xia, Chien-Jen Chen, Pei-Jer Chen, Hwai-I Yang
BACKGROUND & AIMS: Although a low level of hepatitis B surface antigen (HBsAg) is a marker of hepatitis B virus (HBV) seroclearance, additional biomarkers are needed for more accurate prediction. We investigated whether quantification of antibody against HBV core protein (anti-HBc) can identify patients with undetectable levels of HBV DNA and HBsAg seroclearance among those who were HBV e antigen (HBeAg)-seronegative. METHODS: We performed a retrospective analysis of data from a community-based cohort of individuals (30-65 years old) in Taiwan who were HBsAg seropositive, anti-HCV negative, and free of cirrhosis and or liver cancer, recruited from 1991 through 1992, and evaluated every 6-12 months until June 30, 2004...
May 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29750893/disparities-in-initiation-of-direct-acting-antiviral-agents-for-hepatitis-c-virus-infection-in-an-insured-population
#12
Julia L Marcus, Leo B Hurley, Scott Chamberland, Jamila H Champsi, Laura C Gittleman, Daniel G Korn, Jennifer B Lai, Jennifer O Lam, Mary Pat Pauly, Charles P Quesenberry, Joanna Ready, Varun Saxena, Suk I Seo, David J Witt, Michael J Silverberg
OBJECTIVES: The cost of direct-acting antiviral agents (DAAs) for hepatitis C virus (HCV) infection may contribute to treatment disparities. However, few data exist on factors associated with DAA initiation. METHODS: We conducted a retrospective cohort study of HCV-infected Kaiser Permanente Northern California members aged ≥18 during October 2014 to December 2016, using Poisson regression models to evaluate demographic, behavioral, and clinical factors associated with DAA initiation...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29749324/changes-in-acute-viral-hepatitis-epidemiology-in-the-turkish-adult-population-a-multicenter-study
#13
Zehra Karacaer, Selma Tosun, Ayşe Batırel, Suzan Şahin, İrem Altaş, Serhat Uysal, Serpil Erol, Nurgül Ceran, Ayşe Albayrak, İlknur Esen Yıldız, Uğur Kostakoğlu, Fatma Kaçar, Nuretdin Kuzhan, Ayten Kadanalı, Gül Karagöz, Ercan Yenilmez, Derya Bayırlı Turan, Arzu Altunçekiç Yıldırım, Funda Koçak, Rıza Aytaç Çetinkaya, Mehmet Parlak, Özlem Aydın, Pınar Ergen, Gül Durmuş, Türkkan Öztürk Kaygusuz, Özgur Dağlı, Canan Demir, Fatma Yılmaz Karadağ
BACKGROUND/AIMS: The present study aimed to determine the changes in the epidemiology of hepatitis in recent years in an adult Turkish population. MATERIALS AND METHODS: Overall, 852 patients with acute viral hepatitis from 17 centers were included in this study. Their sociodemographic characteristics, clinical courses, treatments, and laboratory findings were retrospectively analyzed. RESULTS: The most commonly found microorganisms were the hepatitis B virus (55...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29742228/sofa-in-the-first-24-hours-as-an-outcome-predictor-of-acute-liver-failure
#14
Edison Moraes Rodrigues-Filho, Rogério Fernandes, Anderson Garcez
OBJECTIVE: To describe a cohort of patients with acute liver failure and to analyze the demographic and clinical factors associated with mortality. METHODS: Retrospective cohort study in which all patients admitted for acute liver failure from July 28, 2012, to August 31, 2017, were included. Clinical and demographic data were collected using the Epimed System. The SAPS 3, SOFA, and MELD scores were measured. The odds ratios and 95% confidence intervals were estimated...
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29741704/incidence-and-predictors-of-hbsag-loss-after-peginterferon-therapy-in-hbeag-negative-chronic-hepatitis-b-a-multicenter-long-term-follow-up-study
#15
I-Cheng Lee, Sien-Sing Yang, Chieh-Ju Lee, Chien-Wei Su, Yuan-Jen Wang, Keng-Hsin Lan, Han-Chieh Lin, Ming-Chih Hou, Cheng-Yuan Peng, Yi-Hsiang Huang
Background: The long-term incidence and factors associated with HBsAg loss in HBeAg-negative chronic hepatitis B (CHB) patients receiving peginterferon is rarely reported. Methods: From 2004 to 2016, 233 HBeAg-negative CHB patients who completed 48 weeks of peginterferon treatment from three medical centers in Taiwan were retrospectively enrolled. Results: During a median follow-up of 7.4 years, 27 cases achieved HBsAg loss. The cumulative incidences of HBsAg loss and HBsAg seroconversion at 3, 5, 10 years after peginterferon treatment were 4...
May 7, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29741634/serum-hbv-rna-as-a-predictor-of-peginterferon-alfa-2a-40kd-response-in-patients-with-hbeag-positive-chronic-hepatitis-b
#16
Florian van Bömmel, Alena van Bömmel, Alexander Krauel, Cynthia Wat, Vedran Pavlovic, Lei Yang, Danilo Deichsel, Thomas Berg, Stephan Böhm
Background: Hepatitis B virus (HBV) RNA is a novel serum biomarker that has the potential to predict treatment response in patients with chronic hepatitis B. We explored whether HBV RNA serum levels can predict hepatitis B e antigen (HBeAg) seroconversion in patients treated with peginterferon alfa-2a. Methods: Serum samples from HBeAg-positive patients previously treated with peginterferon alfa-2a in two large randomized controlled trials were retrospectively analyzed...
May 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29741286/comparison-of-overall-survival-between-antiviral-induced-viral-suppression-and-inactive-phase-chronic-hepatitis-b-patients
#17
Young Youn Cho, Jeong-Hoon Lee, Young Chang, Joon Yeul Nam, Hyeki Cho, Dong Hyeon Lee, Eun Ju Cho, Dong Ho Lee, Su Jong Yu, Jeong Min Lee, Yoon Jun Kim, Jung-Hwan Yoon
Nucleot(s)ide analogues (NAs) reduce the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. However, the risk of HCC is reportedly higher for NA-treated patients than for patients in the inactive CHB phase. This study aimed to compare the long-term outcomes of CHB patients with NA-induced viral suppression and those of patients with inactive CHB. This retrospective study involved 1,118 consecutive CHB patients whose HBV DNA level was continuously <2,000 IU/mL during follow up with/without antiviral agents...
May 9, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29739076/quantitative-hepatitis-b-e-antigen-a-better-predictor-of-hepatitis-b-virus-dna-than-quantitative-hepatitis-b-surface-antigen
#18
Shuaibu A Hudu, Mohd T Niazlin, Syafinaz A Nordin, Mohammed I Saeed, Soek S Tan, Haniza Omar, Hamiza Shahar, Zamberi Sekawi
BACKGROUND: Hepatitis B surface antigen is usually secreted by infected hepatocytes in the form of subviral particles rather than infectious virions, while the hepatitis B e antigen originates from the core gene and is modified and secreted by hepatocytes into the circulation and functions as a marker of active viral replication. This study aimed to study the relationship between HBV DNA and quantitative hepatitis B surface and e antigen in Malaysian patients. METHODS: A total of 82 chronic hepatitis B patients were recruited for this study from the Hepatology Department of Selayang Hospital...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29739046/albumin-bilirubin-score-predicts-short-term-mortality-in-patients-with-hepatitis-b-virus-related-decompensated-cirrhosis
#19
Xiao T Qi
BACKGROUND: The albumin-bilirubin (ALBI) score is a new index for assessing the severity of liver dysfunction. Hepatitis B virus (HBV) related decompensated cirrhosis (HBV-DeCi) has a high short-term mortality rate. The purpose of this study was to elucidate the prognostic role of the ALBI score in patients with HBV-DeCi. METHODS: This retrospective study included 81 patients who had been diagnosed with HBV-DeCi. All patients were followed up with for at least 2 months, and the relationships between prognosis and ALBI score were analysed...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738011/prevalence-of-hepatitis-b-c-and-hiv-among-patients-attending-a-teaching-dental-hospital-a-7-year-retrospective-study-from-the-united-arab-emirates
#20
Suhail H Al-Amad
OBJECTIVES: To determine the seroprevalence and case characteristics of hepatitis B, C and human immunodeficiency virus (HIV), and their transmissibility from patients to dental personnel following percutaneous and mucocutaneous injuries. METHODS: All incidents of sharp and splash injuries reported between January 2010 and January 2017 were retrospectively reviewed and analyzed. Descriptive statistics were calculated using the Statistical Package for the Social Science (SPSS)...
May 2018: Saudi Medical Journal
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