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hepatitis B retrospective

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https://www.readbyqxmd.com/read/28340509/liver-transplant-lt-recipients-with-nonalcoholic-steatohepatitis-nash-have-lower-risk-hepatocellular-carcinoma-hcc
#1
Sara M Lewin, Neil Mehta, R Kate Kelley, John P Roberts, Francis Y Yao, Danielle Brandman
BACKGROUND: Liver transplantation is a well-established treatment for HCC in carefully selected patients. Risk factors for tumors with poor prognostic features on explant have not been well described in a national cohort. METHODS: We performed a retrospective cohort study of adult LT recipients with HCC transplanted from 4/8/12 (when explant pathology in UNOS became available) until 9/30/2014. We evaluated the association between listing diagnosis and other demographic factors with tumor features on explant using logistic regression...
March 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28328813/evaluation-of-apri-and-fib-4-for-noninvasive-assessment-of-significant-fibrosis-and-cirrhosis-in-hbeag-negative-chb-patients-with-alt%C3%A2-%C3%A2-%C3%A2-2-uln-a-retrospective-cohort-study
#2
Qiang Li, Xiaojing Ren, Chuan Lu, Weixia Li, Yuxian Huang, Liang Chen
To evaluate the performance of aspartate transaminase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4) to predict significant fibrosis and cirrhosis in hepatitis B virus e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients with alanine transaminase (ALT) ≤ twice the upper limit of normal (2 ULN).Histologic and laboratory data of 236 HBeAg-negative CHB patients with ALT ≤ 2 ULN were analyzed. Predicted fibrosis stage, based on established scales and cut-offs for APRI and FIB-4, was compared with METAVIR scores obtained from liver biopsy...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328801/influence-of-polymorphisms-in-the-wnt-%C3%AE-catenin-pathway-genes-on-hepatocellular-carcinoma-risk-in-a-chinese-han-population
#3
Qing-Min Li, Feng-Qin Zhang, Ya-Feng Li, Qing-Jie Xian, Yan-Qiang Zhang, Peng Li
The Wnt/β-catenin pathway plays a vital role in initiating and sustaining hepatocellular carcinoma (HCC). However, few studies have investigated polymorphisms in the Wnt/β-catenin signaling pathway genes in the Chinese Han population. The aim of the present retrospective study was to investigate the correlations between polymorphisms of the Wnt/β-catenin signaling pathway genes (CTNNB1 and WNT2) and HCC susceptibility, development, and progression.Twenty tagging single nucleotide polymorphisms were chosen from HapMap data and genotyped in 320 patients with HCC, 320 chronic hepatitis B virus (HBV)-infected patients without HCC (N-HCC, including 95 liver cirrhosis, 164 chronic hepatitis B, and 61 asymptomatic HBV carriers), and 320 healthy controls...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328795/hepatitis-b-serological-markers-and-plasma-dna-concentrations-baseline-results-from-the-dart-trial
#4
Huw Price, David Dunn, Tamale Zachary, Tobias Vudriko, Michael Chirara, Cissy Kityo, Paula Munderi, Moira Spyer, James Hakim, Charles Gilks, Pontiano Kaleebu, Deenan Pillay, Richard Gilson
OBJECTIVES: To examine hepatitis B serological markers and plasma DNA concentrations in a large group of untreated HIV-HBV co-infected individuals in two sub-Saharan settings. DESIGN: Baseline analysis of a randomised controlled trial. METHODS: DART was a large trial of treatment monitoring practices in HIV-infected adults with advanced disease starting antiretroviral therapy at centres in Kampala or Entebbe, Uganda (n = 2,317) and Harare, Zimbabwe (n = 999)...
March 21, 2017: AIDS
https://www.readbyqxmd.com/read/28323868/-waiting-for-daas-a-retrospective-chart-review-of-patients-with-untreated-hepatitis-c-in-rwanda
#5
Neil Gupta, Jules Kabahizi, Constance Mukabatsinda, Timothy David Walker, Emmanuel Musabeyezu, Athanase Kiromera, Jennifer Ilo Van Nuil, Kevin Steiner, Joia Mukherjee, Sabin Nsanzimana, Aimable Mbituyumuremyi
BACKGROUND: Access to treatment for hepatitis C virus (HCV) in sub-Saharan Africa is extremely limited. With the advent of direct acting antivirals (DAAs), highly effective and easy-to-deliver oral regimens are now available on the global market. This study was conducted to understand the background and characteristics of a national cohort of patients with HCV infection enrolled in care and awaiting therapy with DAAs. METHODS AND FINDINGS: We conducted a retrospective chart review of all adult patients with confirmed HCV infection who were currently enrolled in care and treatment at the four existing hepatitis referral centers in Rwanda...
2017: PloS One
https://www.readbyqxmd.com/read/28323748/serum-aminotransferase-flares-in-pregnant-and-postpartum-women-with-current-or-prior-treatment-for-chronic-hepatitis-b
#6
Christine Y Chang, Natali Aziz, Mugilan Poongkunran, Asad Javaid, Huy N Trinh, Daryl T Lau, Mindie H Nguyen
BACKGROUND AND AIMS: Antiviral therapy is recommended for pregnant women with chronic hepatitis B (CHB) and hepatitis B virus (HBV) DNA>200,000 IU/mL, but there is less consensus on management of women who discontinue therapy in anticipation of pregnancy or who become pregnant while on therapy. The goal of this study was to describe flares in alanine aminotransferase (ALT) during pregnancy and postpartum in CHB women with current and/or prior treatment. METHODS: This was a multicenter, retrospective study of 67 pregnancies in 56 CHB women treated before and/or during pregnancy...
March 20, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28323377/accuracy-of-pdff-estimation-by-magnitude-based-and-complex-based-mri-in-children-with-mr-spectroscopy-as-a-reference
#7
William M Haufe, Tanya Wolfson, Catherine A Hooker, Jonathan C Hooker, Yesenia Covarrubias, Alex N Schlein, Gavin Hamilton, Michael S Middleton, Jorge E Angeles, Diego Hernando, Scott B Reeder, Jeffrey B Schwimmer, Claude B Sirlin
PURPOSE: To assess and compare the accuracy of magnitude-based magnetic resonance imaging (MRI-M) and complex-based MRI (MRI-C) for estimating hepatic proton density fat fraction (PDFF) in children, using MR spectroscopy (MRS) as the reference standard. A secondary aim was to assess the agreement between MRI-M and MRI-C. MATERIALS AND METHODS: This was a HIPAA-compliant, retrospective analysis of data collected in children enrolled in prospective, Institutional Review Board (IRB)-approved studies between 2012 and 2014...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28320050/the-practice-pattern-of-hepatitis-b-testing-in-rheumatoid-arthritis-patients-a-cross-national-comparison-between-us-and-taiwan
#8
Tzu-Chieh Lin, Nikroo Hashemi, Seoyoung C Kim, Yea-Huei Kao Yang, Kazuki Yoshida, Sara Tedeschi, Rishi Desai, Daniel H Solomon
OBJECTIVE: The Hepatitis B Virus (HBV) testing rates and patterns in rheumatoid arthritis (RA) patients starting disease modifying anti-rheumatic drugs (DMARDs) have not been well studied. We describe and compare the practice patterns of HBV testing among RA patients in U.S. and Taiwan. METHODS: We conducted a retrospective cohort study including RA patients starting first DMARD in U.S. or Taiwan. The first date patients newly received any DMARD was defined as the index date, and the 1-year period before the index date was the baseline period...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28319602/low-hepatic-tissue-copper-in-pediatric-non-alcoholic-fatty-liver-disease
#9
Michael Mendoza, Shelley Caltharp, Ming Song, Lindsay Collin, Juna V Konomi, Craig J McClain, Miriam B Vos
OBJECTIVE: Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in non-alcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children. METHODS: This was a retrospective study of pediatric patients who had a liver biopsy including a hepatic copper quantitation. The primary outcome compared hepatic copper concentration in NAFLD versus non-NAFLD...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28316217/-comparison-of-the-effect-of-lymph-node-dissection-performed-by-ivor-lewis-or-left-sided-thoracic-esophagogastrectomy-for-siewert-type-%C3%A2-adenocarcinoma-of-the-esophagogastric-junction
#10
X F Duan, L Gong, M Q Ma, J Yue, P Tang, X B Shang, H J Jiang, Z T Yu
Objective: To compare the extent of lymphadenectomy and postoperative complications between Ivor-Lewis procedure and left sided thoracotomy in patients with Siewert type Ⅱ adenocarcinoma of the esophagogastric junction (AEG). Methods: The clinical data of 101 patients with Siewert type Ⅱ EG who received surgical treatment between January 2014 and September 2015 in the Department of Esophageal Cancer, Tianjin Medical University Cancer Hospital were analyzed retrospectively. These patients were divided into Ivor-Lewis group (IL, n=38) and left- sided thoracotomy group (LT, n=63) according to the operation mode...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28315754/hepatitis-b-and-htlv-1-co-infection-in-the-northern-territory-australia
#11
Ian Marr, Jane Davies, Rob W Baird
OBJECTIVE: To establish the relationship of Hepatitis B and HTLV-1 serological markers in the Northern Territory, Australia. METHODS: A retrospective serological study of patients, presenting to public healthcare facilities, in the Northern Territory between 2008 and 2015, was performed to determine presence and relationships of serological markers of Hepatitis B virus (HBV), and Human T-cell Leukemic virus 1 (HTLV-1). RESULTS: There were 740 individual cases of serological positive HTLV-1 identified over 8 years in the Northern Territory...
March 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28314596/on-treatment-hbv-dna-level-could-predict-hbeag-seroclearance-in-patients-with-hbeag-positive-chronic-hepatitis-b-with-entecavir-therapy
#12
Yi-Jie Huang, Chi-Sen Chang, Yen-Chun Peng, Hong-Zen Yeh, Sheng-Shun Yang
BACKGROUND: Hepatitis B e antigen (HBeAg) status is associated with clinical outcomes, and seroconversion of HBeAg is one of the treatment goals. In this study, we determined the association of on-treatment serum hepatitis B virus (HBV) DNA levels in HBeAg-positive chronic hepatitis B patients who were receiving entecavir (ETV) treatment. METHODS: A retrospective cohort study was conducted involving 135 (78 male and 57 female; mean age, 42.3 ± 13 years) patients with HBeAg-positive chronic hepatitis B (CHB)...
March 14, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28302512/seroepidemiology-of-hepatitis-a-hepatitis-b-and-varicella-virus-in-people-living-with-hiv-in-ireland
#13
Corinna Sadlier, Anna O'Rourke, Alison Carr, Colm Bergin
Epidemiological studies investigating seroprevalence of vaccine preventable infections at both individual and population level are important in guiding screening and vaccination practices. Data on seroprevalence of common vaccine preventable infections in HIV-infected individuals is lacking. We carried out a retrospective cohort study to investigate serological immunity and factors associated with immunity to hepatitis A virus (HAV), hepatitis B virus (HBV) and varicalla virus (VZV) in a cohort of HIV-infected individuals attending a large ambulatory HIV specialist centre in Ireland...
March 13, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28301992/effect-of-downstaging-and-bridging-of-hepatocellular-carcinoma-on-survival-following-liver-transplant-a-single-center-experience
#14
Mohammed I Al Sebayel, Hussien Elsiesy, Waleed Al-Hamoudi, Saleh Alabbad, Yasser ElSheikh, Hany Elbeshbeshy, Isam Salih, Sarra Yousif, Yahia Saleh, Abdulmoneim Eldali, Faisal A Abaalkhail
OBJECTIVES: Hepatocellular carcinoma is among the leading causes of cancer death. The Milan criteria are the first and most widely used criteria for selecting patients with hepatocellular carcinoma for a good transplant outcome. Studies have shown that patients with hepatocellular carcinoma outside the Milan criteria have good outcomes if they are successfully downstaged before transplant. We report our experience with locoregional therapy for hepatocellular carcinoma, either for bridging or for downstaging prior to transplant...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28299974/causes-of-peripheral-cytopenia-in-hepatitic-cirrhosis-and-portal-hypertensive-splenomegaly
#15
Yunfu Lv, Wan Yee Lau, Hongfei Wu, XiaoYu Han, Xiaoguang Gong, Ning Liu, Jie Yue, Qingqing Li, YeJuan Li, Jie Deng
The clinical data of 183 patients with hepatitic cirrhosis and portal hypertensive splenomegaly complicated by peripheral cytopenia were retrospectively analyzed to investigate the causes of peripheral cytopenia, as well as the proportion of the causes in these patients. All patients underwent splenectomy. Before operation, these patients had one or more types of peripheral cytopenia (cumulative cytopenia: 390 patient-times). After splenectomy, blood counts in 79.2% (309/390) returned to normal, while in 15...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28296915/genetic-variation-in-the-vitamin-d-pathway-cyp2r1-gene-predicts-sustained-hbeag-seroconversion-in-chronic-hepatitis-b-patients-treated-with-pegylated-interferon-a-multicenter-study
#16
Kessarin Thanapirom, Sirinporn Suksawatamnuay, Wattana Sukeepaisarnjareon, Tawesak Tanwandee, Phunchai Charatcharoenwitthaya, Satawat Thongsawat, Apinya Leerapun, Teerha Piratvisuth, Rattana Boonsirichan, Chalermrat Bunchorntavakul, Chaowalit Pattanasirigool, Bubpha Pornthisarn, Supot Tantipanichtheerakul, Ekawee Sripariwuth, Woramon Jeamsripong, Teeranan Sanpajit, Yong Poovorawan, Piyawat Komolmit
Evidence of a role of vitamin D in the immune system is increasing. Low serum vitamin D is associated with increased hepatitis B virus replication. Genome-wide association study (GWAS) data has revealed a number of the single nucleotide polymorphisms (SNPs) within the vitamin D synthetic pathway that affect vitamin D functions. We aimed to determine the association between SNPs in the vitamin D gene cascade and response to pegylated interferon (PegIFN) therapy in hepatitis B e-antigen (HBeAg)-positive patients...
2017: PloS One
https://www.readbyqxmd.com/read/28283858/combination-therapy-with-lamivudine-and-angiotensin-converting-enzyme-inhibitor-angiotensin-receptor-blocker-for-hepatitis-b-virus-associated-glomerulonephritis-with-mild-to-moderate-proteinuria-a-clinical-review-of-38-cases
#17
Li-Jing Sun, Jian-Ping Shan, Ruo-Lan Cui, Wei-Jie Yuan, Geng-Ru Jiang
PURPOSE: The treatment of HBV-associated glomerulonephritis (HBV-GN) is still a challenge in clinical practice now. The objective of this study was to report the pathological characteristics of HBV-GN presenting with mild to moderate proteinuria and to evaluate the therapeutic efficacy of lamivudine (LAM) in combination with angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) as compared to ACEI/ARB monotherapy. METHODS: We conducted a retrospective observational study in HBV-GN patients between 2005 and 2014...
March 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28274240/effect-of-48-week-pegylated-interferon-%C3%AE-2a-or-nucleos-t-ide-analogue-therapy-on-renal-function-in-chinese-patients-with-chronic-hepatitis-b
#18
Ye Zhang, Wei-Lu Zhang, Xiao-Wen Pang, Lin-Xu Wang, Xin Wei, Chang-Xing Huang, Xue-Fan Bai, Shuai Han, Lin-Na Liu, Jian-Qi Lian
BACKGROUND: Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal function of chronic hepatitis B (CHB) patients in response to anti-HBV therapy and the association with treatments. METHOD: We performed a retrospective observational cohort study to investigate factors associated with renal function in 249 Chinese CHB patients who were treated with pegylated interferon α-2a (PEG-IFN-α-2a) or nucleos(t)ide analogues for 48 weeks...
March 9, 2017: Virology Journal
https://www.readbyqxmd.com/read/28273387/long-term-trends-in-chronic-hepatitis-b-virus-infection-associated-liver-transplantation-outcomes-in-the-united-states
#19
Kellie Young, Benny Liu, Taft Bhuket, Zobair Younossi, Sammy Saab, Aijaz Ahmed, Robert J Wong
With effective antiviral therapies, rates of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and decompensated liver disease requiring liver transplantation (LT) are expected to decrease. We aim to evaluate overall trends in LT waitlist registrations, waitlist survival, and likelihood of receiving LT among chronic HBV patients in the U.S. Using the United Network for Organ Sharing database, we retrospectively evaluated adults (age >18) with chronic HBV (with and without HCC) listed for LT from 1992-1996 (Era 1) vs...
March 8, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28271305/the-validity-of-hcc-diagnosis-codes-in-chronic-hepatitis-b-patients-in-the-veterans-health-administration
#20
Ronald Omino, Sahil Mittal, Jennifer R Kramer, Maneerat Chayanupatkul, Peter Richardson, Fasiha Kanwal
BACKGROUND: Administrative databases that include diagnostic codes are valuable sources of information for research purposes. AIM: To validate diagnostic codes for hepatocellular carcinoma (HCC) in chronic hepatitis B patients. METHODS: We conducted a retrospective study of patients with chronic HBV seen in the national Veterans Administration (VA). HCC cases were identified by the presence of ICD-9 code 155.0. We randomly selected 200 HBV controls without this code as controls...
March 7, 2017: Digestive Diseases and Sciences
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