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hepatitis B descriptive

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https://www.readbyqxmd.com/read/29906637/molecular-epidemiology-of-hepatitis-delta-and-hepatitis-b-viruses-circulating-in-two-major-provinces-east-and-north-west-of-pakistan
#1
Mahwish Aftab, Iram Amin, Muhammad Idrees, Amjad Ali, Shazia Rafique, Shagufta Naz
OBJECTIVES: HBV and HDV are major public health problems with millions affected globally and Pakistan accounts for a significant proportion of the global Hepatitis burden. This cross sectional study was designed to assess the general epidemiological and virological features of HBV and HDV in the Punjab and Khyber Pakhtunkhawa (KP) provinces of Pakistan. METHODS: A total of 1890 HBV patients from March 2016 to May 2017 were recruited in the study and the presence of HDV was retrospectively evaluated in all participants...
June 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29805811/a-seven-year-retrospective-study-on-the-surveillance-of-hepatitis-b-in-laos
#2
Phimpha Paboriboune, Thomas Vial, François Chassagne, Philavanh Sitbounlang, Sengaloun Soundala, Stéphane Bertani, Davone Sengmanothong, Francois-Xavier Babin, Nicolas Steenkeste, Paul Dény, Pascal Pineau, Eric Deharo
Objective: Lao PDR is one of the most highly endemic countries for hepatitis B in Asia and the second country for liver cancer incidence. Therefore, the follow-up of infected individuals through predictive serological markers is of utmost importance to monitor the progression of the pathology and take the decision on treatment. Methods: A retrospective-descriptive cohort study was conducted on 3,857 HBV-infected patients. Information about infection status (viral load, VL), liver function (aminotransferases), and treatments was recorded...
2018: International Journal of Hepatology
https://www.readbyqxmd.com/read/29804396/-comorbidities-and-concomitant-medication-use-in-adult-patients-with-chronic-hepatitis-c-a-descriptive-epidemiological-analysis
#3
Q Wang, H Y Rao, N Yu, S Q Gao, L Wei
Objective: To analyze the comorbidity and concomitant medications use in adult patients with chronic hepatitis C. Methods: A descriptive epidemiological methods was carried out in adult patients with chronic hepatitis C and data from 2013 to 2015 were accessed through the China Medical Insurance database. Results: Among a chronic HCV cohort of 2 958 cases, the top five comorbidities were diabetes, hypertension, ischemic heart disease, gastroduodenitis, and co-infection with HBV and HCV. The three most common concomitant medications prescribed for mentioned comorbidities were acarbose, metformin and repaglinide (Diabetes), nifedipine, amlodipine and metoprolol (Hypertension), aspirin, nifedipine and amlodipine (Ischemic heart disease), omeprazole, pantoprazole and levolfoxacin (Gastroduodenitis), ribavirin, pegylated interferon alpha-2a and alpha-2b ( Co- infected with hepatitis B and C virus)...
March 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29769062/seroprevalence-of-hiv-htlv-cmv-hbv-and-rubella-virus-infections-in-pregnant-adolescents-who-received-care-in-the-city-of-bel%C3%A3-m-par%C3%A3-northern-brazil
#4
Aubaneide Batista Guerra, Leonardo Quintão Siravenha, Rogério Valois Laurentino, Rosimar Neris Martins Feitosa, Vânia Nakauth Azevedo, Antonio Carlos Rosário Vallinoto, Ricardo Ishak, Luiz Fernando Almeida Machado
BACKGROUND: Prenatal tests are important for prevention of vertical transmission of various infectious agents. The objective of this study was to describe the prevalence of human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B virus (HBV), cytomegalovirus (CMV), rubella virus and vaccination coverage against HBV in pregnant adolescents who received care in the city of Belém, Pará, Brazil. METHODS: A cross-sectional study was performed with 324 pregnant adolescents from 2009 to 2010...
May 16, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29762630/acute-on-chronic-liver-failure-in-china-rationale-for-developing-a-patient-registry-and-baseline-characteristics
#5
Wen-Yi Gu, Bao-Yan Xu, Xin Zheng, Jinjun Chen, Xian-Bo Wang, Yan Huang, Yan-Hang Gao, Zhong-Ji Meng, Zhi-Ping Qian, Feng Liu, Xiao-Bo Lu, Jia Shang, Hai Li, Shao-Yang Wang, Xin Sun, Hai Li
Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus(HBV) are the main etiologies, respectively. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a multicenter prospective cohort with the same inclusion criteria and disease indicators as those used in the European CANONIC (Chronic liver failure-ACLF in Cirrhosis) study is urgently needed in Asia, where the prevalence of HBV is high...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29753787/studying-sparsely-populated-conformational-states-in-rna-combining-chemical-synthesis-and-solution-nmr-spectroscopy
#6
Elisabeth Strebitzer, Felix Nußbaumer, Johannes Kremser, Martin Tollinger, Christoph Kreutz
Using chemical synthesis and solution NMR spectroscopy, RNA structural ensembles including a major ground state and minor populated excited states can be studied at atomic resolution. In this work, atom-specific 13 C labeled RNA building blocks - a 5-13 C-uridine and a 2,8-13 C2 -adenosine building block - are used to introduce isolated 13 C-1 H-spin topologies into a target RNA to probe such structural ensembles via NMR spectroscopy. First, the 5-13 C-uridine 2'-O-TBDMS-phosphoramidite building block was introduced into a 21 nucleotide (nt) tP5c stem construct of the tP5abc subdomain of the Tetrahymena group I ribozyme...
May 10, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29738011/prevalence-of-hepatitis-b-c-and-hiv-among-patients-attending-a-teaching-dental-hospital-a-7-year-retrospective-study-from-the-united-arab-emirates
#7
Suhail H Al-Amad
OBJECTIVES: To determine the seroprevalence and case characteristics of hepatitis B, C and human immunodeficiency virus (HIV), and their transmissibility from patients to dental personnel following percutaneous and mucocutaneous injuries. METHODS: All incidents of sharp and splash injuries reported between January 2010 and January 2017 were retrospectively reviewed and analyzed. Descriptive statistics were calculated using the Statistical Package for the Social Science (SPSS)...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29700417/progression-and-regression-of-fibrosis-in-viral-hepatitis-in-the-treatment-era-the-beijing-classification
#8
Neil D Theise, Jidong Jia, Yameng Sun, Aileen Wee, Hong You
In this new era of successful long term suppression of hepatitis B viral replication and consistent eradication of hepatitis C virus the necessity for routine pre-treatment biopsies has often been eliminated. Thus, whether there is utility to perform liver biopsy in chronic viral hepatitis is undergoing re-examination. In response to these changing needs, we have developed a new staging system, the Beijing Classification, for assessment of biopsy specimens from patients with chronic viral hepatitis. The most important novelty of the Beijing Classification is that it includes not only extent (stage) of fibrosis, but the quality of fibrosis, namely if the specimen shows predominantly regressive vs...
April 26, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29644251/twenty-year-evolution-of-hepatitis-b-virus-and-human-immunodeficiency-virus-prevalence-and-incidence-in-voluntary-blood-donors-in-c%C3%A3-te-d-ivoire
#9
Benjamin Seri, Albert Minga, Delphine Gabillard, Bamori Dembele, Seidou Konate, Jérôme Le Carrou, Lambert Dohoun, Yao Abo, Sophie Karcher, Patrick Coffie, Thérèse N'Dri-Yoman, Alain Attia, Serge P Eholié, Christine Danel, Karine Lacombe, Xavier Anglaret, Anders Boyd
Background: Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) share common risk factors. The parallel description of their frequency over time may help capture their similarities and differences. Methods: Using data from the National Transfusion Center of Abidjan, we estimated the following over a 20-year period: (1) the prevalence of HIV and hepatitis B surface antigen (HBsAg) positivity at first contact; and (2) the incidence of HIV and HBsAg seroconversion in negative first-time blood donors...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29596409/distinct-inflammatory-profile-underlies-pathological-increases-in-creatinine-levels-associated-with-plasmodium-vivax-malaria-clinical-severity
#10
Luís A B Cruz, Manoel Barral-Netto, Bruno B Andrade
BACKGROUND: Although Plasmodium vivax infection is a frequent cause of malaria worldwide, severe presentations have been more regularly described only in recent years. In this setting, despite clinical descriptions of multi-organ involvement, data associating it with kidney dysfunction are relatively scarce. Here, renal dysfunction is retrospectively analyzed in a large cohort of vivax malaria patients with an attempt to dissect its association with disease severity and mortality, and to determine the role of inflammation in its progression...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29579055/proportion-and-predictors-of-transfusion-transmissible-infections-among-blood-donors-in-north-shewa-zone-central-north-ethiopia
#11
Tekalign Deressa, Wubet Birhan, Bamlaku Enawgaw, Molla Abebe, Habtamu Wondiferaw Baynes, Mekuria Desta, Betelihem Terefe, Mulugeta Melku
BACKGROUND: Transfusion-transmissible infections (TTIs) pose a significant challenge for the availability and safety of blood transfusion. The aim of this study was to investigate the prevalence and risk factors for TTIs among blood donors in North Shewa zone, central North Ethiopia. METHODS: A retrospective survey of blood donors' medical records was conducted from April 2014 to June 2017 to assess the presence of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis infections...
2018: PloS One
https://www.readbyqxmd.com/read/29561969/liver-transplantation-in-hepatitis-delta-south-america-experience
#12
Daniel Souza Lima, Abdon José Murad Júnior, Márcio Alencar Barreira, Guilherme Cardoso Fernandes, Gustavo Rego Coelho, José Huygens Parente Garcia
BACKGROUND: The Amazon region is one of the main endemic areas of hepatitis delta in the world and the only one related to the presence of genotype 3 of the delta virus. OBJECTIVE: To analyze the profile, mortality and survival of cirrhotic patients submitted to liver transplantation for chronic hepatitis delta virus and compare with those transplanted by hepatitis B virus monoinfection. METHODS: Retrospective, observational and descriptive study...
January 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29554828/management-of-hepatitis-b-reactivation-in-lymphoma-patients-on-rituximab-with-past-hepatitis-b-exposure-an-observational-study
#13
Denise Yeo, Ihtimam Hossain, Soon Thye Lim, Mohamad Farid, Miriam Tao, Richard Quek, Tiffany Tang, Alexandre Chan
Background Currently, a standardized approach to prevent and manage hepatitis B reactivation in lymphoma patients with past hepatitis exposure receiving rituximab in Singapore is lacking. This study is designed to report the current management approach and outcomes associated with hepatitis B reactivation. Objectives The primary objective was to report 6-, 12-, 24-month cumulative hepatitis B reactivation-related outcomes. Secondary objectives were to report monitoring frequencies of hepatitis B DNA and liver function tests performed in lymphoma patients with resolved hepatitis B receiving rituximab, and anti-viral prophylaxis use...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29534608/nucleoside-analogs-as-a-rich-source-of-antiviral-agents-active-against-arthropod-borne-flaviviruses
#14
Luděk Eyer, Radim Nencka, Erik de Clercq, Katherine Seley-Radtke, Daniel Růžek
Nucleoside analogs represent the largest class of small molecule-based antivirals, which currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis B or C viruses, and herpes viruses. High antiviral potency and favorable pharmacokinetics parameters make some nucleoside analogs suitable also for the treatment of acute infections caused by other medically important RNA and DNA viruses. This review summarizes available information on antiviral research of nucleoside analogs against arthropod-borne members of the genus Flavivirus within the family Flaviviridae, being primarily focused on description of nucleoside inhibitors of flaviviral RNA-dependent RNA polymerase, methyltransferase, and helicase/NTPase...
January 2018: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29520729/pharmacokinetics-and-safety-of-velpatasvir-and-sofosbuvir-velpatasvir-in-subjects-with-hepatic-impairment
#15
Erik Mogalian, Diana M Brainard, Anu Osinusi, Lisa Moorehead, Bernard Murray, Kah Hiing John Ling, Robert Perry, Craig Curtis, Eric Lawitz, Kenneth Lasseter, Thomas Marbury, Anita Mathias
BACKGROUND: The pharmacokinetics and safety of velpatasvir, a potent pangenotypic hepatitis C virus NS5A inhibitor, were evaluated in two hepatic impairment studies: a phase I study in hepatitis C virus-uninfected subjects and a phase III study (ASTRAL-4) in hepatitis C virus-infected patients. METHODS: In the phase I study, subjects with moderate or severe hepatic impairment (Child-Pugh-Turcotte Class B or C), and demographically matched subjects with normal hepatic function received a single dose of velpatasvir 100 mg...
March 8, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29512233/screening-recipients-of-increased-risk-donor-organs-a-multicenter-retrospective-study
#16
Michael G Ison, Meenakshi M Rana, Kyle D Brizendine, Sonia Chimienti, Jade Le, Rosette Kfoury, Parvin Mohazabnia, Nicole Theodoropoulos
Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29482629/primary-carcinosarcoma-of-the-liver-imaging-features-and-clinical-findings-in-six-cases-and-a-review-of-the-literature
#17
Jing Li, Pan Liang, Dandan Zhang, Jie Liu, Hongkai Zhang, Jinrong Qu, Jianbo Gao
BACKGROUND: Carcinosarcoma of the liver is a very rare tumor composed of a mixture of carcinomatous and sarcomatous elements. Less than 25 adequately documented cases have been reported, with inadequate description of imaging features. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinicopathologic and imaging features of six cases of hepatic carcinosarcoma (HCS) confirmed by surgical pathologic evaluation. METHODS: We retrospectively studied the clinicopathologic and imaging features of six cases of HCS (matching the World Health Organization definition) and discussed the differential diagnosis on the basis of imaging findings...
February 27, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29459805/-hepatitis-b-and-c-prevalence-in-a-blood-bank-at-general-hospital-in-callao-peru
#18
Liliana Alvarez, Paul Jesús Tejada-Llacsa, Giannina Melgarejo-García, Gabriel Berto, Pedro Montes Teves, Eduardo Monge
OBJECTIVE: The aim of the present study was to determine the prevalence of sero positivity for HBsAg, Anti-HBcAg and AntiHVC in the blood bank of Hospital Daniel Carrion during the period 2010 - 2012. MATERIALS AND METHODS: Retrospective cross-sectional study. Potential donors who met the inclusion criteria were included. Sociodemographic factors, risk behaviors were gathered. A descriptive analysis was performed with STATA 14. RESULTS: 13,887 potential blood donors of the HNDAC between January 2010 and December 2012 were identified...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29453472/prevalence-of-hepatitis-d-among-patients-with-hepatitis-b-viral-infection-attending-a-tertiary-care-centre-of-nepal
#19
Kiran Regmi, Jeetendra Kaji Shrestha, Sudhamshu Kc, Bikash Jaishi, Niyanta Karki, Dipendra Khadka, Sandip Khadka
INTRODUCTION: Worldwide there is variation in prevalence of Hepatitis D viral infection. Superinfection and co infection with hepatitis B viral infection is known to occur in 15-20 million people. METHODS: This was a descriptive cross-sectional hospital based study carried out in NAMS, Bir hospital, Kathmandu, Nepal from period of January 2017 to June 2017. Consecutive patients of chronic hepatitis B viral infection of HBsAg positive with more than two-time upper normal limit of ALT were enrolled and tested for HDV IgG...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29416843/perceptions-and-practice-of-health-care-workers-regarding-hepatitis-b-vaccination-bouak%C3%A3-c%C3%A3-te-d-ivoire-2016
#20
Damus Kouassi, Odile Angbo-Effi, Lepri Aka, M'Bégnan Coulibaly, Sory Soumahoro, Gnissan Yao, Nagho Soro
Barriers to immunization are seen in both the general population and the health care workforce. We conducted this study to determine the perception of health workers on vaccination and the immunization of their patients. This cross-sectional descriptive analytical study was carried out among the medical staff in Bouaké, from 10 January to 07 March 2016. The data collected from the interviews were analyzed using Epi info 2000 software and SPSS 17.0. The Chi-2 test and logistic regression were performed and the significance threshold of the tests was 5%...
December 31, 2017: Journal of Public Health in Africa
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