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hepatitis B clinical patterns

Fuchu Qian, Jiqu Qin, Dongli Li, Zhihong Ma, Hairong Zhang, Fang Jin, Weihong Wang
INTRODUCTION: Antiviral drug-resistance patterns of hepatitis B virus (HBV) mutants are complex and currently partly understood. The aim of this study was to monitor the genotypic resistance profile in patients with chronic hepatitis B (CHB) receiving nucleos(t)ide analogues (NAs) in Huzhou, eastern China. METHODOLOGY: Serum samples of 139 CHB patients undergoing NA treatment were obtained from Huzhou Central Hospital. The full-length HBV reverse transcriptase regions were amplified and sequenced...
September 30, 2016: Journal of Infection in Developing Countries
Kübra Altinel, Kosuke Hashimoto, Yu Wei, Christine Neuveut, Ishita Gupta, Ana Maria Suzuki, Alexandre Dos Santos, Pierrick Moreau, Tian Xia, Soichi Kojima, Sachi Kato, Yasuhiro Takikawa, Isao Hidaka, Masahito Shimizu, Tomokazu Matsuura, Akihito Tsubota, Hitoshi Ikeda, Sumiko Nagoshi, Harukazu Suzuki, Marie-Louise Michel, Didier Samuel, Marie Annick Buendia, Jamila Faivre, Piero Carninci
: Hepatitis B virus (HBV) is a major cause of liver diseases including hepatocellular carcinoma (HCC), and more than 650,000 people die annually due to HBV-associated liver failure. Extensive studies of individual promoters have revealed that heterogeneous RNA 5' -ends contribute to the complexity of HBV transcriptome and proteome. Here we provide a comprehensive map of HBV transcription start sites (TSSs) in human liver, HCC and blood, as well as several experimental replication systems, at single nucleotide resolution...
September 28, 2016: Journal of Virology
Bing-Fang Chen
AIM: To investigate the associations of different types of pre-S deletions with hepatitis B virus (HBV) genotypes. METHODS: The sequences of the pre-S region, basal core promoter (BCP) mutation, and precore (PC) mutation were examined through direct DNA sequencing or clonal analysis and sequencing in 273 HBV carriers, namely 55 asymptomatic carriers, 55 carriers with chronic hepatitis (CH), 55 with liver cirrhosis (LC), 53 with liver cirrhotic hepatocellular carcinoma (LC-HCC), and 55 with noncirrhotic HCC...
September 21, 2016: World Journal of Gastroenterology: WJG
Young-Hsiang Lin, Shih-Kai Hung, Wen-Yen Chiou, Moon-Sing Lee, Bing-Jie Shen, Liang-Cheng Chen, Dai-Wei Liu, Wei-Ta Tsai, Po-Hao Lin, Yi-Ting Shih, Feng-Chun Hsu, Shiang-Jiun Tsai, Michael W Y Chan, Hon-Yi Lin
BACKGROUND: Clinically, elderly patients with unresectable bulky hepatocellular carcinoma (HCC) are difficult to manage, especially in those with co-infections of hepatitis B and C virus. Herein, we reported such a case treated with radiotherapy (RT) by using combined simultaneously integrated inner-escalated boost and volumetric-modulated arc radiotherapy (SIEB-VMAT). After RT, significant symptoms alleviation and durable tumor control were observed. CASE SUMMARY: At presentation, an 85-year-old male patient complained abdominal distention/pain, poor appetite, and swelling over bilateral lower limbs for 1 month...
August 2016: Medicine (Baltimore)
Houda Chaouch, Stefania Taffon, Umbertina Villano, Michele Equestre, Roberto Bruni, Manel Belhadj, Naila Hannachi, Mahjoub Aouni, Amel Letaief, Anna Rita Ciccaglione
In Tunisia, the prevalence of naturally occurring surface (S) gene variants of hepatitis B virus (HBV) has not been determined. In the present study, the prevalence of these variants was examined in terms of the clinical and viral state in a series of 99 Tunisian patients with HBV infection. The S genes were amplified and directly sequenced. Genotype D was predominant (98%), 40.4% isolates belonged to subgenotypes D7 and 1 to subgenotype D2. The most common subtype was ayw2 (95.9%). In total, 60.6% of the studied strains harbored S mutations...
2016: Intervirology
Wei Jing, Ping Luo, Man Zhu, Qian Ai, Hongyan Chai, Jiancheng Tu
BACKGROUND: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Due to the lack of early prediction marker, numerous patients were diagnosed in their late stage. The family of cavins plays important roles in caveolae formation and cellular processes. Cavin-2, one of the members of cavins, has been reported as a suppresser in cancers. In this study, we have investigated its expression pattern and clinical significance in HCC. METHODS: RT‑qPCR was performed to detect the expression of cavin-2...
2016: Cellular Physiology and Biochemistry
Sébastien Imbert, Louise Castain, Antoine Pons, Stéphanie Jacob, Isabelle Meyer, Martine Palous, Corinne Vezinet, Olivier Langeron, Christophe Hennequin, Antoine Monsel, Arnaud Fekkar
OBJECTIVES: to give an indication of a fitness cost conferred by FKS mutation-associated echinocandin resistance in Candida glabrata during human infection. METHODS: six C. glabrata clinical strains sequentially isolated from blood and a hepatic abscess in a solid organ transplant recipient were analysed. The patient had received long-term azole and echinocandin therapy for invasive aspergillosis and persistent candidemia. Minimal inhibitory concentrations were determined by the EUCAST broth microdilution method...
July 30, 2016: Clinical Microbiology and Infection
Forough Golsaz-Shirazi, Hamed Mohammadi, Mohammad Mehdi Amiri, Jalal Khoshnoodi, Gholam Ali Kardar, Mahmood Jeddi-Tehrani, Fazel Shokri
The common "a" determinant is the major immunodominant region of hepatitis B surface antigen (HBsAg) shared by all serotypes and genotypes of hepatitis B virus (HBV). Antibodies against this region are thought to confer protection against HBV and are essential for viral clearance. Mutations within the "a" determinant may lead to conformational changes in this region, which can affect the binding of neutralizing antibodies. There is an increasing concern about identification and control of mutant viruses which is possible by comprehensive structural investigation of the epitopes located within this region...
October 2016: Archives of Virology
María Belén Rodrigo, Laura Noelia Mojsiejczuk, Carolina Torres, Ina Sevic, María Mora González López Ledesma, Paula Soledad Perez, María Belén Bouzas, Omar Galdame, Sebastián Marciano, Hugo Fainboim, Diego Martín Flichman, Rodolfo Héctor Campos
Hepatitis B virus (HBV) is a globally distributed human pathogen that leads to both self-limited and chronic infections. At least eight genotypes (A-H) with distinct geographical allocations and phylodynamic behaviors have been described. They differ substantially in many virological and probably some clinical parameters. The aim of this study was to analyze full-length HBV genome sequences from individuals with symptomatic acute HBV infections using phylogenetic and coalescent methods. The phylogenetic analysis resulted in the following subgenotype distribution: F1b (52...
2016: PloS One
Xiaodong Li, Yaqun Qin, Yan Liu, Fan Li, Hao Liao, Shanshan Lu, Yan Qiao, Dongping Xu, Jin Li
BACKGROUND: The association of hepatitis B virus (HBV) preS1 and preS2 deletions with progressive liver diseases are not fully understood. OBJECTIVE: The study aimed to investigate characteristics of HBV preS deletion in HBV-infected patients with different illness categories. STUDY DESIGN: Total of 539 HBV-infected patients were enrolled in the study, including 146 with chronic hepatitis B (CHB), 111 with HBV-related liver cirrhosis (LC), 146 with HBV-related acute-on-chronic liver failure (ACLF), and 136 with HBV-related hepatocellular carcinoma (HCC)...
September 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Niroshana J Dahanayaka, Tomoko Kiyohara, Suneth B Agampodi, Pradeep K Samaraweera, Gayani K Kulasooriya, Jagath C Ranasinghe, Saveen N Semage, Sayaka Yoshizaki, Takaji Wakita, Koji Ishii
Sri Lanka is one of the intermediate-endemic areas for hepatitis A virus (HAV), and concerns exist about the increasing HAV-susceptible population. In fact, Sri Lanka recorded a large hepatitis outbreak, possibly hepatitis A, around the end of the Sri Lankan war. It included more than 14,000 patients consisting of local residents, internally displaced personnel, and military personnel in the main combat zone. The outbreak had slowed down by October 2009; however, acute viral hepatitis continued to occur sequentially among military personnel...
July 5, 2016: American Journal of Tropical Medicine and Hygiene
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Yue Liu, Zhong-Xia Wang, Yin Cao, Guang Zhang, Wei-Bo Chen, Chun-Ping Jiang
BACKGROUND: Recurrence of hepatocellular carcinoma (HCC) after curative resection remains a major cause of treatment failure and tumor-related death. Patterns of HCC recurrence can be categorized into early recurrence and late recurrence which have different underlying mechanisms. In this study, we investigated if simple inflammation-based clinical markers can distinguish patterns of recurrence after curative resection of HCC. METHODS: A retrospective analysis of 223 patients who underwent curative hepatectomy for HCC was performed...
June 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
J S Bajaj, R T Frederick, N M Bass, M Ghabril, K Coyne, M K Margolis, M Santoro, D F Coakley, M Mokhtarani, M Jurek, B F Scharschmidt
Clinical management and clinical trials of patients with overt hepatic encephalopathy (OHE) are compromised by lack of standardized and reproducible tools for its clinical diagnosis or for caregiver (CG) identification of OHE manifestations which merit medical evaluation. Using an iterative Delphi method, Steering Committee and international hepatologist panel, the West Haven (WH) scale was modified to develop and operationalize a clinician tool for OHE identification and grading (HE Grading Instrument, HEGI™)...
October 2016: Metabolic Brain Disease
Yinuo Huang, Hong Ma, Shutang Wei, Gang Luo, Ruimin Sun, Zhibo Fan, Liping Wu, Wenyi Yang, Lin Fu, Junhui Wang, Dazheng Han, Jun Lu
Cytotoxic T lymphocytes (CTLs) are important for the recognition of the hepatitis B virus (HBV), mediating immunoprotective mechanisms and determining the clinical outcome following HBV infection. CTLs recognize the invading virus via the T cell receptor (TCR). The aim of the current study was to investigate the variability of TCR in lymphocytes from patients with chronic hepatitis B and whether TCR genomic recombination is regulated by the current treatment strategies. Peripheral blood mononuclear cells (PBMCs) were isolated from patients with chronic hepatitis B and high‑throughput sequencing was performed to analyze the gene expression diversity of β chain complementarity determining region...
July 2016: Molecular Medicine Reports
Yu-Ming Guo, Feng-Yi Li, Man Gong, Lin Zhang, Jia-Bo Wang, Xiao-He Xiao, Jun Li, Yan-Ling Zhao, Li-Fu Wang, Xiao-Feng Zhang
OBJECTIVE: To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction (, YCZFD) in the treatment of acute-on-chronic liver failure caused by hepatitis B virus (HBV-ACLF) with cold pattern in Chinese medicine (CM). METHODS: This is a multi-center randomized controlled trial of integrative treatment of CM and Western medicine (WM) for the management of HBV-ACLF patients. A total of 200 HBV-ACLF patients with cold pattern were equally randomly assigned to receive YCZFD and WM (integrative treatment) or WM conventional therapy alone respectively for 4 weeks...
August 2016: Chinese Journal of Integrative Medicine
Mabrouk I Ismail, Khaled Lakouz, Eman Abdelbary
To evaluate the clinicopathological correlation of renal pathology and outline the frequencies of different renal diseases, beside assessment of lupus nephritis (LN), we studied 150 patients [72 (48%) males and mean age of 33.82 ± 15.4 years] who were subjected to native renal biopsy; 112 (72.8%) biopsied patients were diagnosed to have glomerulonephritis (GN). The most frequent clinical renal syndrome was nephrotic syndrome found in 55 (36.6%) patients, followed by nephritic syndrome in 38 (25.3%) patients, chronic kidney disease in 28 (18...
May 2016: Saudi Journal of Kidney Diseases and Transplantation
Friedhelm Schroeder, Avery L McIntosh, Gregory G Martin, Huan Huang, Danilo Landrock, Sarah Chung, Kerstin K Landrock, Lawrence J Dangott, Shengrong Li, Martin Kaczocha, Eric J Murphy, Barbara P Atshaves, Ann B Kier
The first discovered member of the mammalian FABP family, liver fatty acid binding protein (FABP1, L-FABP), occurs at high cytosolic concentration in liver, intestine, and in the case of humans also in kidney. While the rat FABP1 is well studied, the extent these findings translate to human FABP1 is not clear-especially in view of recent studies showing that endocannabinoids and cannabinoids represent novel rat FABP1 ligands and FABP1 gene ablation impacts the hepatic endocannabinoid system, known to be involved in non-alcoholic fatty liver (NAFLD) development...
June 2016: Lipids
Rachel B Weinstein, Martijn J Schuemie, Patrick B Ryan, Paul E Stang
BACKGROUND: Presumed seasonal use of acetaminophen-containing products for relief of cold/influenza ("flu") symptoms suggests that there might also be a corresponding seasonal pattern for acute liver injury (ALI), a known clinical consequence of acetaminophen overdose. OBJECTIVE: The objective of this study was to determine whether there were any temporal patterns in hospitalizations for ALI that would correspond to assumed acetaminophen use in cold/flu season. METHODS: In the period 2002-2010, monthly hospitalization rates for ALI using a variety of case definitions were calculated...
2016: Drug, Healthcare and Patient Safety
Damien C Tully, Simon Hjerrild, Peter D Leutscher, Signe G Renvillard, Colin B Ogilvie, David J Bean, Poul Videbech, Todd M Allen, Jane A McKeating, Nicola F Fletcher
BACKGROUND & AIMS: Hepatitis C virus (HCV) causes neuropsychiatric impairment and fatigue with recent studies suggesting HCV invasion of the central nervous system (CNS). Our previous finding that endothelial cells from the blood-brain barrier support HCV infection warrants further investigation to elucidate whether the CNS can serve as a reservoir for independent HCV evolution. METHODS: Cerebrospinal fluid (CSF) and plasma from six HCV-infected patients without liver disease or co-morbidities together with plasma from six healthy subjects were profiled for markers of immune activation and viral quasispecies measured by deep sequencing...
October 2016: Liver International: Official Journal of the International Association for the Study of the Liver
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