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hepatitis b patterns

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https://www.readbyqxmd.com/read/29684438/the-cytoskeleton-in-couch-potato-ism-insights-from-a-murine-model-of-impaired-actin-dynamics
#1
Karen Gertz, Ria Uhlemann, Anna Foryst-Ludwig, Ruben Marquina Barrientos, Kai Kappert, Christa Thöne-Reineke, Pierre Djoufack, Clemens Kirschbaum, Klaus B Fink, Andreas Heinz, Ulrich Kintscher, Matthias Endres, Golo Kronenberg
Evidence for a critical pathophysiological role of aberrant cytoskeletal dynamics is being uncovered in a growing number of neuropsychiatric syndromes. A sedentary lifestyle as well as overt psychopathology is prevalent in patients with the metabolic syndrome. Using mice deficient in gelsolin (Gsn-/- ), a crucial actin-severing protein, we here investigated reduced actin turnover as a potential common driver of metabolic disturbances, sedentary behavior, and an anxious/depressive phenotype. Gelsolin deficiency resulted in reduced lifespan...
April 20, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29682303/heterogeneity-in-hepatitis-c-treatment-prescribing-and-uptake-in-australia-a-geospatial-analysis-of-a-year-of-unrestricted-treatment-access
#2
EDITORIAL
Nick Scott, Samuel W Hainsworth, Rachel Sacks-Davis, Alisa Pedrana, Joseph Doyle, Amanda Wade, Margaret Hellard
Background and aim: Direct-acting antiviral (DAA) treatments became available for all people living with hepatitis C virus (HCV) in Australia in March 2016. We assess variations in treatment rates and prescribing patterns across Australia's 338 Statistical Area 3 (SA3) geographical units. Methods: Geocoded DAA treatment initiation data were analysed for the period 1 March 2016 to 30 June 2017. Regression models tested associations between the population demographics and healthcare service coverage of geographical areas and (a) their treatment rates; and (b) the proportion of prescriptions written by specialists compared to non-specialists...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29675099/hepatitis-b-virus-infection-dampens-ctip-expression-in-hepatoma-cell
#3
Dongxin Zhang, Haojing Liu, Jusheng Lin, Duyun Ye
Hepatitis B virus (HBV) infection is a leading cause for hepatocellular carcinoma (HCC). Dysregulation of DNA double-strand break (DSB) repair may explain the pathogenesis of HBV-related HCC. Tumor suppressor CtIP plays a critical role in DSB repair. The purpose of present study was to clarify whether HBV affects CtIP expression in DSB repair of hepatoma cell. HepG2.2.15 was selected as the HBV positive hepatoma cell line, while HepG2 as the HBV negative hepatoma cell line. The two cell lines were treated with bleomycin to induce DSB...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29652648/pre-s2-start-codon-mutation-of-hepatitis-b-virus-subgenotype-b3-effects-on-nf-%C3%AE%C2%BAb-expression-and-activation-in-huh7-cell-lines
#4
Marlinang Diarta Siburian, Ivet Marita Suriapranata, Septelia Inawati Wanandi
A cross-sectional study on hepatitis B patients in Indonesia showed association of pre-S2 start codon mutation (M120 V) with cirrhosis and hepatocellular carcinoma (HCC), which was dissimilar from studies from other populations where pre-S2 deletion mutation was more prevalent. Different mutation patterns were attributed to different hepatitis B virus (HBV) subgenotypes in each population study. HBV surface proteins are reported to induce the activation of NF-κB, a transcriptional factor known to play an important role in the development of liver disease...
March 19, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29648506/systemic-equid-alphaherpesvirus-9-in-a-grant-s-zebra
#5
Robert B Moeller, Beate Crossley, Arlena Pipkin, Yanqiu Li, Udeni B R Balasuriya
A 2-y-old female Grant's zebra ( Equus quagga [ burchellii] boehmi) was presented with a clinical history of depression, anorexia, and weakness of 1-wk duration. Postmortem examination identified ulcers on the tongue and palate; a large abscess adjacent to the larynx; left lung consolidation; mild swelling, darkening, and congestion of the liver with accentuation of the lobular pattern; and edema and congestion of the distal small and large intestines. Histologic examination identified necrotizing bronchopneumonia, necrotizing hepatitis, nephritis, and enterocolitis...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29621351/spatial-distribution-of-12-class-b-notifiable-infectious-diseases-in-china-a-retrospective-study
#6
Bin Zhu, Yang Fu, Jinlin Liu, Ying Mao
BACKGROUND: China is the largest developing country with a relatively developed public health system. To further prevent and eliminate the spread of infectious diseases, China has listed 39 notifiable infectious diseases characterized by wide prevalence or great harm, and classified them into classes A, B, and C, with severity decreasing across classes. Class A diseases have been almost eradicated in China, thus making class B diseases a priority in infectious disease prevention and control...
2018: PloS One
https://www.readbyqxmd.com/read/29615081/association-between-serum-s100a9-levels-and-liver-necroinflammation-in-chronic-hepatitis-b
#7
Rui Wu, Yuhong Zhang, Yu Xiang, Yishu Tang, Fang Cui, Ju Cao, Lan Zhou, Yan You, Liang Duan
BACKGROUND: S100A9 protein, which is recently classified as a novel damage associated molecular pattern, is released from stressed cells undergoing necrosis or secreted by living cells undergoing a stress that act as endogenous danger signal associated with infection, tissue damage and cancer. Here, we evaluated the relationship of serum S100A9 with viral replication and liver necroinflammation in patients with chronic hepatitis B (CHB) infection. METHODS: A total of one hundred and eighty-three recruited patients with CHB infection underwent liver biopsy for grading of necroinflammation (G) and staging of fibrosis (S)...
April 3, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29614809/spatio-temporal-epidemiology-of-viral-hepatitis-in-china-2003-2015-implications-for-prevention-and-control-policies
#8
Bin Zhu, Jinlin Liu, Yang Fu, Bo Zhang, Ying Mao
Viral hepatitis, as one of the most serious notifiable infectious diseases in China, takes heavy tolls from the infected and causes a severe economic burden to society, yet few studies have systematically explored the spatio-temporal epidemiology of viral hepatitis in China. This study aims to explore, visualize and compare the epidemiologic trends and spatial changing patterns of different types of viral hepatitis (A, B, C, E and unspecified, based on the classification of CDC) at the provincial level in China...
April 2, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29601782/hepatic-phd2-hif-1%C3%AE-axis-is-involved-in-postexercise-systemic-energy-homeostasis
#9
Beibei Luo, Dao Xiang, Die Wu, Changcheng Liu, Yiqun Fang, Peijie Chen, Yi-Ping Hu
Exercise plays an important role in the prevention and treatment of chronic liver disease and associated metabolic disorders. A single bout of exercise induces tissue blood flow redistribution, which decreases splanchnic circulation and leads to physiologic hypoxia in the gastrointestinal system and liver. The transcription factor, hypoxia inducible factor-1α (HIF-1α), and its regulator, prolylhydroxylase 2 (PHD2), play pivotal roles in the response to oxygen flux by regulating downstream gene expression levels in the liver...
March 30, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29599909/rna-binding-protein-auf1-suppresses-mir-122-biogenesis-by-down-regulating-dicer1-in-hepatocellular-carcinoma
#10
Xia Wu, Yingzhuo Yang, Yike Huang, Yang Chen, Tianying Wang, Shuo Wu, Lei Tong, Yan Wang, Lexun Lin, Meili Hao, Zhao-Hua Zhong, Fengmin Zhang, Wenran Zhao
Hepatocellular carcinoma (HCC) is one of the common cancers worldwide, especially in developing countries. Although the chronic infections of hepatitis B and C viruses have been established as the etiological factors of HCC, the mechanism for the tumorigenesis and development of HCC is still unclear. The liver-specific microRNA-122 (miR-122), an established tumor-suppressor miRNA, is often down-regulated in HCC, while the underlying mechanism is not well understood. Here we report that the AU-rich element-binding factor AUF1 suppresses the expression of Dicer1, the type III RNase that is required for microRNA maturation, leading to the inhibited biogenesis of miR-122...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29593208/clinical-characteristics-and-correlation-analysis-of-subjects-with-chronic-hepatitis-b-virus-hbv-infection-and-sustained-low-levels-of-hepatitis-b-surface-antigen-hbsag
#11
Jun Cheng, Yuzhu Dai, Li Yan, Huajun Zhou, Xujian Xu, Changgui Sun, Zhongyong Wang
BACKGROUND The aim of this study was to investigate the clinical characteristics of individuals with chronic hepatitis B virus (HBV) infection with persistent low levels of hepatitis B surface antigen (HBsAg) and to undertake a correlation analysis of the clinical characteristics. MATERIAL AND METHODS The study included 1,204 subjects with chronic HBV infection. Serum HBsAg, HBV envelope antigen (HBeAg), and HBV core antigen (HBcAg) levels were measured using the chemiluminescent microparticle immunoassay (CMIA) and the neutralization test...
March 29, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29578596/social-cultural-traditional-beliefs-and-health-system-barriers-of-hepatitis-b-screening-among-hmong-americans-a-case-study
#12
Dao M Fang, Susan L Stewart
BACKGROUND: The incidence of liver cancer in Hmong Americans is 5 times higher than that of non-Hispanic whites, and there is a low hepatitis B screening rate (24%) among Hmong adults compared with other Asian American populations. The purpose of this study was to examine the Hmong's perceptions on social-cultural determinants, traditional health beliefs, and health care system barriers that influenced community-based hepatitis B screening interventions. METHODS: A qualitative method was used, integrating a collective case study research design...
April 1, 2018: Cancer
https://www.readbyqxmd.com/read/29578397/fibrillary-glomerulonephritis-in-an-hiv-patient-without-concurrent-hepatitis-c-infection-case-report-and-review-of-the-literature
#13
Lian Zhang, John M Carson, M Scott Lucia
The most common renal disease associated with human immunodeficiency virus infection (HIV) is HIV-associated nephropathy (HIVAN), especially in the African American patient population. However, various patterns of glomerulonephritis (GN) are not uncommon, collectively accounting for nearly half of the renal biopsies performed in HIV patients. Most GNs that occur in HIV patients are immune complex mediated, often with concurrent infections such as hepatitis B or C. Fibrillary glomerulonephritis (FGN), a rare primary glomerular disease, has only been reported in 2 HIV patients, and both patients had concurrent hepatitis C (HCV) infection...
March 26, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29577518/quantification-of-serum-markers-of-hepatitis-b-hbv-and-delta-virus-hdv-infections-in-patients-with-chronic-hdv-infection
#14
Gabriele Ricco, Delia Codruta Popa, Daniela Cavallone, Speranta Iacob, Antonio Salvati, Daniela Tabacelia, Filippo Oliveri, Giovanni Mascolo, Ferruccio Bonino, Quan Yuan, Ning-Shao Xia, Liana Gheorghe, Maurizia Rossana Brunetto
The interplay between hepatitis B (HBV) and Delta (HDV) viruses is complex and not always characterized during chronic HDV infection. We assessed the clinical usefulness of new quantitative assays for HBV and HDV serum markers in a retrospective cross-sectional study. Sera obtained from 122 HDV-genotype-1 and HBV-genotype-D co-infected, anti-HIV-negative patients [71 males; median age 49.8 (21.7-66.9) years], recruited consecutively in two geographic areas (Italy 69 patients, Romania 53) with different HBV and HDV epidemiology, were tested for HBsAg, HBV-DNA, HBcrAg, total anti-HBc, HDV-RNA, IgM and total anti-HDV using quantitative assays...
March 25, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29576871/-de-novo-hnf1-homeobox-b-mutation-as-a-cause-for-chronic-treatment-resistant-hypomagnesaemia
#15
C E Stiles, R Thuraisingham, D Bockenhauer, L Platts, A V Kumar, M Korbonits
29-year-old female presenting with an 8-year history of unexplained hypomagnesaemia, which was severe enough to warrant intermittent inpatient admission for intravenous magnesium. Urinary magnesium was inappropriately normal in the context of hypomagnesaemia indicating magnesium wasting. Ultrasound imaging demonstrated unilateral renal cysts and computed tomography of kidneys, ureters and bladder showed a bicornuate uterus. Referral to genetic services and subsequent testing revealed a de novo HNF1B deletion...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29574937/serologic-markers-of-viral-infection-and-risk-of-non-hodgkin-lymphoma-a-pooled-study-of-three-prospective-cohorts-in-china-and-singapore
#16
Bryan A Bassig, Martina Willhauck-Fleckenstein, Xiao-Ou Shu, Woon-Puay Koh, Yu-Tang Gao, Mark P Purdue, Yong-Bing Xiang, Jennifer Adams-Haduch, Renwei Wang, Nicole Brenner, Tim Waterboer, Angelika Michel, Bu-Tian Ji, H Dean Hosgood, Charles S Rabkin, Gong Yang, Jason Y Y Wong, Jinming Zhang, Wei Hu, Wei Jie Seow, Wong-Ho Chow, Michael Pawlita, Wei Zheng, Jian-Min Yuan, Qing Lan, Nathaniel Rothman
Incidence rates of non-Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre-diagnostic blood and NHL risk in East Asians. We conducted a nested case-control study of 214 NHL cases and 214 matched controls from three population-based prospective cohorts in Shanghai and Singapore. Antibodies against antigens from herpesviruses, Hepatitis B (HBV) and C (HCV) virus, and polyomaviruses were measured in plasma or serum using fluorescent bead-based multiplex assays...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29572624/significance-and-management-of-isolated-hepatitis-b-core-antibody-anti-hbc-in-hiv-and-hcv-strategies-in-the-daa-era
#17
REVIEW
Jennifer J Chang, Neaka Mohtashemi, Debika Bhattacharya
PURPOSE OF REVIEW: The purpose of this review is to summarize the prevalence and clinical implications of the isolated anti-HBc serologic profile in HIV-infected individuals. We highlight the rare but important issue of HBV reactivation in the setting of HCV therapy and describe an approach to management. RECENT FINDINGS: The isolated anti-HBc pattern, a profile that most often indicates past exposure to HBV with waning anti-HBs immunity, is found commonly in HIV-infected individuals, particularly those with HCV...
March 23, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29559070/anova-health-institute
#18
Johannes M Hugo, Kevin B Rebe, Evan Tsouroulis, Anthony Manion, Glenn de Swart, Helen Struthers, James A McIntyre
Chemsex is the colloquial term used for a specific pattern of drug use that is increasingly common among men who have sex with men (MSM) globally. The recreational substances employed are used specifically in a sexualized context. The reasons for chemsex among MSM are complex. The Anova Health Institute (Anova) provided harm-reduction services in Cape Town, South Africa in 2013 and 2014. This project, known as Tikking the Boxes had two objectives: first to provide direct harm-reduction services to drug-using MSM in Cape Town, South Africa, and second, to reduce HIV and hepatitis B and C transmission among this population...
March 21, 2018: Sexual Health
https://www.readbyqxmd.com/read/29551632/clinical-course-of-sporadic-acute-hepatitis-e-in-a-hepatitis-b-virus-endemic-region
#19
Li Liu, Di Xiao, Jin-Hong Yu, Rui Shen, Meng Wang, Qiang Li
OBJECTIVES: In China, the epidemic pattern of acute hepatitis E virus (HEV) infection has changed from waterborne outbreaks to foodborne sporadic cases. However, the clinical course of sporadic acute hepatitis E has not been well defined. METHODS: Consecutive AHE inpatients who were admitted to the Jinan Infectious Disease Hospital, Jinan, Shandong Province, between January 2003 and December 2014 were evaluated and followed. Demographic data, clinical manifestations, results of laboratory tests,and outcomes were recorded...
March 15, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29550589/non-lytic-lymphocytes-engineered-to-express-virus-specific-t-cell-receptors-limit-hbv-infection-by-activating-apobec3
#20
Sarene Koh, Janine Kah, Christine Y L Tham, Ninghan Yang, Erica Ceccarello, Adeline Chia, Margaret Chen, Atefeh Khakpoor, Andrea Pavesi, Anthony T Tan, Maura Dandri, Antonio Bertoletti
BACKGROUND & AIMS: Strategies to develop virus-specific T cells against hepatic viral infections have been hindered by safety concerns. We engineered non-lytic human T cells to suppress replication of hepatitis B virus (HBV) and hepatitis C virus (HCV) without overt hepatotoxicity, and investigated their antiviral activity. METHODS: We electroporated resting T cells or T cells activated by anti-CD3 with mRNAs encoding HBV or HCV-specific T-cell receptors (TCRs) to create 2 populations of TCR-reprogrammed T cells...
March 14, 2018: Gastroenterology
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