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hepatitis b patterns

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https://www.readbyqxmd.com/read/29224133/epidemiology-of-chronic-hepatitis-b-virus-in-ireland-using-routinely-collected-surveillance-and-administrative-data-2004-2014
#1
Caroline E van Gemert, Niamh Murphy, Tara A Mitchell, Margaret E Hellard, Thornton Thornton
BACKGROUND: Ireland has a low prevalence of chronic hepatitis B virus (HBV) infection; however, there are limited recently published epidemiological data. This study aimed to describe the epidemiology of chronic HBV in Ireland between 2004 and 2014 using routine surveillance data and identify and interrogate additional data sources in Ireland to complement the interpretation of HBV surveillance data. METHODS: Routinely collected passive surveillance data of notified cases of HBV infection were collated for 2004-2014...
December 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29219628/penetration-enhancer-containing-spanlastics-pecss-for-transdermal-delivery-of-haloperidol-in-vitro-characterization-ex-vivo-permeation-and-in-vivo-biodistribution-studies
#2
Abdurrahman M Fahmy, Doaa Ahmed El-Setouhy, Ahmed B Ibrahim, Basant A Habib, Saadia A Tayel, Noha A Bayoumi
Haloperidol (Hal) is one of the widely used antipsychotic drugs. When orally administered, it suffers from low bioavailability due to hepatic first pass metabolism. This study aimed at developing Hal-loaded penetration enhancer-containing spanlastics (PECSs) to increase transdermal permeation of Hal with sustained release. PECSs were successfully prepared using ethanol injection method showing reasonable values of percentage entrapment efficiency, particle size, polydispersity index and zeta potential. The statistical analysis of the ex vivo permeation parameters led to the choice of F1L - made of Span® 60 and Tween® 80 at the weight ratio of 4:1 along with 1% w/v Labrasol® - as the selected formula (SF)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29218243/elevated-hbxip-expression-is-associated-with-aggressive-phenotype-and-poor-prognosis-in-esophageal-squamous-cell-carcinoma
#3
Honggang Xia, Lan Ma, Jing Li, Hongyu Bai, Dongbin Wang
The oncoprotein hepatitis B virus X-interacting protein (HBXIP) has been suggested to play an essential role in several malignancies. However, the clinicopathological significance and prognostic value of HBXIP expression in esophageal squamous cell carcinoma (ESCC) is still unknown. Therefore the aim of this study was to characterize HBXIP expression and its prognostic value in ESCC. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to assess the mRNA and protein expression of HBXIP in ESCC tissues and cell lines...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29218046/tlr2-expression-in-peripheral-cd4-t-cells-promotes-th17-response-and-is-associated-with-disease-aggravation-of-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#4
Chunli Xu, Yinping Lu, Xin Zheng, Xuemei Feng, Xuecheng Yang, Joerg Timm, Jun Wu, Baoju Wang, Mengji Lu, Dongliang Yang, Jia Liu
Th17 responses have been shown to play crucial roles in the pathogenesis of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (ACLF). The mechanism underlying the enhanced Th17 responses in these patients remains largely unclear. Here we investigated toll-like receptors (TLRs) expression in peripheral T cells and their roles in Th17 cell differentiation and disease aggravation in ACLF patients. 18 healthy subjects (HS), 20 chronic HBV-infected (CHB) patients, and 26 ACLF patients were enrolled and examined for TLRs expression in peripheral blood mononuclear cells (PBMCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29212479/a-pilot-systematic-genomic-comparison-of-recurrence-risks-of-hepatitis-b-virus-associated-hepatocellular-carcinoma-with-low-and-high-degree-liver-fibrosis
#5
Seungyeul Yoo, Wenhui Wang, Qin Wang, M Isabel Fiel, Eunjee Lee, Spiros P Hiotis, Jun Zhu
BACKGROUND: Chronic hepatitis B virus (HBV) infection leads to liver fibrosis, which is a major risk factor in hepatocellular carcinoma (HCC) and an independent risk factor of recurrence after HCC tumor resection. The HBV genome can be inserted into the human genome, and chronic inflammation may trigger somatic mutations. However, how HBV integration and other genomic changes contribute to the risk of tumor recurrence with regards to the different degree of liver fibrosis is not clearly understood...
December 7, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29207378/characteristics-of-hepatocellular-carcinoma-aggressiveness-factors-in-turkish-patients
#6
Hikmet Akkiz, Brian I Carr, Kendal Yalçın K, Vito Guerra, Sedef Kuran, Engin Altıntaş, Oğuz Üsküdar, Ümit Karaoğullarından, Ayşegül Özakyol, Salih Tokmak, Mehmet Yücesoy, Halil İbrahim Bahçeci, Abdulalh Ülkü, Tolga Akçam, Kamil Yalçın Polat, Nazım Ekinci, Halis Şimşek, Necati Örmeci, Abdulalh Sonsuz, Mehmet Demir, Murat Kılıç, Ahmet Uygun, Tuğsan Ballı, Ali Demir, Burcu Arslan, Figen Doran
A large cohort of hepatocellular carcinoma (HCC) patients from several collaborating Turkish institutions were examined for the tumor parameters of maximum diameter (MTD), portal vein thrombosis (PVT), and α-fetoprotein (AFP) levels. A relationship was found between MTD and blood platelet levels. Patients with large ≥5 cm tumors who had normal platelet levels had significantly larger tumors, higher percent of PVT, and significantly lower blood total bilirubin and liver cirrhosis than similar ≥5 cm tumor patients having thrombocytopenia...
December 6, 2017: Oncology
https://www.readbyqxmd.com/read/29202690/distinct-patterns-of-serum-hepatitis-b-core-related-antigen-during-the-natural-history-of-chronic-hepatitis-b
#7
Zhan-Qing Zhang, Xiao-Nan Zhang, Wei Lu, Yan-Bing Wang, Qi-Cheng Weng, Yan-Ling Feng
BACKGROUND: The current clinical practice on chronic hepatitis B (CHB) requires better on-treatment monitoring of viral persistence. Quantified assays for hepatitis B surface antigen (HBsAg) and core-related antigen (HBcrAg) hold promise for further optimization of therapy. Here, we aimed to characterize HBcrAg during the natural course of CHB. METHODS: Four-hundred and forty four treatment naïve CHB patients, who all underwent liver histology examination, were enrolled in this cross-sectional study...
December 4, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#8
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
December 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29194684/global-micro-rna-expression-profiling-in-the-liver-biopsies-of-hepatitis-b-virus-infected-patients-suggests-specific-mirna-signatures-for-viral-persistence-and-hepatocellular-injury
#9
Avishek Kumar Singh, Sheetalnath Babasaheb Rooge, Aditi Varshney, Madavan Vasudevan, Ankit Bhardwaj, Senthil Kumar Venugopal, Nirupama Trehanpati, Manoj Kumar, Robert Geffers, Vijay Kumar, Shiv Kumar Sarin
Hepatitis B virus (HBV) can manipulate the miRNA regulatory networks in infected cells to create a permissive environment for viral replication, cellular injury, disease onset and its progression. The aim of the present study was to understand the miRNA networks and their target genes in the liver of hepatitis B patients involved in HBV replication, liver injury and liver fibrosis. We investigated differentially expressed miRNAs by microarray in the liver biopsy samples from different stages of HBV infection and liver disease [immune tolerant (IT; n= 8); acute viral hepatitis (AVH; n=8); no fibrosis (n=16); early (F1+F2) (n=19) or late fibrosis (F3+F4) (n=14) and healthy controls (n=7)]...
November 30, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29182758/microrna-122-targets-genes-related-to-goose-fatty-liver
#10
Jun Zhang, Qian Wang, Xing Zhao, Laidi Wang, Xingguo Wang, Jian Wang, Biao Dong, Daoqing Gong
MicroRNA-122 (miR-122), a completely conserved, liver-specific miRNA in vertebrates, is essential for the maintenance of liver homeostasis. This 22-nucleotide-length RNA regulates diverse functions such as cholesterol, glucose, and lipid metabolism as well as iron homeostasis and infection of hepatitis C virus (HCV). Landes goose, which has a good, fatty liver, has important significance for us in studying miR-122 function in goose fatty liver. In the current study, we identified miR-122 in goose liver and its expression pattern and target genes...
November 22, 2017: Poultry Science
https://www.readbyqxmd.com/read/29180767/frequency-and-reactivity-of-antigen-specific-t-cells-were-concurrently-measured-through-the-combination-of-artificial-antigen-presenting-cell-macs-and-elispot
#11
Chuanlai Shen, Tao Xu, You Wu, Xiaoe Li, Lingzhi Xia, Wei Wang, Khawar Ali Shahzad, Lei Zhang, Xin Wan, Jie Qiu
Conventional peptide-major histocompatibility complex (pMHC) multimer staining, intracellular cytokine staining, and enzyme-linked immunospot (ELISPOT) assay cannot concurrently determine the frequency and reactivity of antigen-specific T cells (AST) in a single assay. In this report, pMHC multimer, magnetic-activated cell sorting (MACS), and ELISPOT techniques have been integrated into a micro well by coupling pMHC multimers onto cell-sized magnetic beads to characterize AST cell populations in a 96-well microplate which pre-coated with cytokine-capture antibodies...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29177849/practice-patterns-in-hepatitis-b-virus-screening-before-cancer-chemotherapy-in-a-major-us-hospital-network
#12
Ye Eun Kwak, Stacy M Stein, Joseph K Lim
BACKGROUND: Cancer patients receiving chemotherapy face an increased risk of reactivation of chronic hepatitis B virus infection. AIM: To determine the HBV screening rate in patients receiving cancer chemotherapy in various clinical settings. METHOD: We identified 11,959 adult cancer patients (age ≥ 18 years) receiving parenteral chemotherapy between 2012 and 2015 within a major US hospital network, including a large university hospital, community teaching hospitals, and community oncology clinics...
November 24, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29173586/differential-immune-related-gene-expression-in-the-spleens-of-duck-tembusu-virus-infected-goslings
#13
Yu He, Anqi Wang, Shun Chen, Zhen Wu, Jinyue Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Kunfeng Sun, Xiaoyue Chen, Anchun Cheng
Flaviviruses pose a significant threat to public health worldwide. Recently, a novel flavivirus, duck Tembusu virus (TMUV), was identified as the causative agent of a serious duck viral disease in Asia. Its rapid spread and expanded host range have raised substantial concerns regarding its potential threat to non-avian hosts, including humans. However, the specific molecular host responses to this virus are poorly understood. In this study, we used the RNA-sequencing technique to analyse the differential gene expression in the spleens of infected goslings 5days post-infection...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29168865/syntheses-crystal-structures-dft-calculations-protein-interaction-and-anticancer-activities-of-water-soluble-dipicolinic-acid-imidazole-based-oxidovanadium-iv-complexes
#14
Debanjana Biswal, Nikhil Ranjan Pramanik, Syamal Chakrabarti, Michael G B Drew, Krishnendu Acharya, Swarnendu Chandra
Three novel water soluble neutral mononuclear oxidovanadium(iv) complexes 1-3, [VOLB2] (where H2L = dipicolinic acid (DPA) and B = imidazole (1)/1-methylimidazole (2)/1-allylimidazole (3)), were synthesized by the reaction of [VOL(H2O)2] with imidazole/1-methylimidazole/1-allylimidazole in ethanol. The complexes were thoroughly characterized by elemental analysis, IR, UV-Vis and EPR spectroscopy, magnetic susceptibility, cyclic voltammetry and single crystal X-ray diffraction techniques. In all the complexes the vanadium(iv) centre assumes a distorted octahedral environment...
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29135988/evolution-of-acute-hepatitis-c-virus-infection-in-a-large-european-city-trends-and-new-patterns
#15
César Garriga, Sandra Manzanares-Laya, Patricia García de Olalla, Pilar Gorrindo, Sabela Lens, Ricard Solà, María Martínez-Rebollar, Montserrat Laguno, Jordi Navarro, Xavier Torras, Mercè Gurguí, María-Jesús Barberá, Josep Quer, Eva Masdeu, Pere Simón, Miriam Ros, Anna de Andrés, Joan A Caylà
The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004-2005, 2006-2011 and 2012-2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data...
2017: PloS One
https://www.readbyqxmd.com/read/29129708/efficacy-of-hepatitis-b-virus-ribonuclease-h-inhibitors-a-new-class-of-replication-antagonists-in-frg-human-liver-chimeric-mice
#16
Kelly R Long, Elena Lomonosova, Qilan Li, Nathan L Ponzar, Juan A Villa, Erin Touchette, Stephen Rapp, R Matt Liley, Ryan P Murelli, Alexandre Grigoryan, R Mark Buller, Lisa Wilson, John Bial, John E Sagartz, John E Tavis
Chronic hepatitis B virus infection cannot be cured by current therapies, so new treatments are urgently needed. We recently identified novel inhibitors of the hepatitis B virus ribonuclease H that suppress viral replication in cell culture. Here, we employed immunodeficient FRG KO mice whose livers had been engrafted with primary human hepatocytes to ask whether ribonuclease H inhibitors can suppress hepatitis B virus replication in vivo. Humanized FRG KO mice infected with hepatitis B virus were treated for two weeks with the ribonuclease H inhibitors #110, an α-hydroxytropolone, and #208, an N-hydroxypyridinedione...
November 10, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29118993/cellular-characteristics-of-keratin-19-positive-canine-hepatocellular-tumours-explain-its-aggressive-behaviour
#17
Renee G van Sprundel, Ted Sgam van den Ingh, Baukje A Schotanus, Monique E van Wolferen, Louis C Penning, Jan Rothuizen, Bart Spee
The expression of the hepatic progenitor cell marker keratin 19 (K19) in canine hepatocellular carcinomas is linked with a poor prognosis. To better understand this aggressive behaviour, K19-positive hepatocellular carcinomas (n=5) and K19-negative hepatocellular adenomas (n=6) were immunohistochemically stained for proteins involved in malignant tumour development. The K19-positive carcinomas showed marked positivity for platelet-derived growth factor receptor alpha polypeptide (PDGFRα), laminin, integrin beta-1/CD29, B-cell-specific Moloney murine leukaemia virus Integration site 1, glypican-3 (GPC-3) and prominin-1/CD133, in contrast with K19-negative hepatocellular adenomas...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29118691/vanishing-tumor-in-a-liver-graft-from-a-hepatitis-b-virus-surface-antigen-positive-donor
#18
Mayo Fuchino, Kazuto Tajiri, Masami Minemura, Toshiro Sugiyama
We report a case of vanishing tumor considered as inflammatory pseudotumor (IPT) found in the liver after living donor liver transplantation (LDLT) from a hepatitis B virus surface antigen-positive donor. The radiological findings were similar to those of hepatocellular carcinoma (HCC). However, the tumor disappeared completely within several months and was suggested to have been an IPT. IPT is known to be associated with biliary duct operation or biliary infection, and it can show various enhancement patterns in radiological studies, sometimes resembling HCC...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29118562/obstetricians-and-gynecologists-knowledge-education-and-practices-regarding-chronic-hepatitis-b-in-pregnancy
#19
Bolin Niu, Dina Halegoua-De Marzio, Jonathan M Fenkel, Steven K Herrine
Background: In pregnant women with high viral loads, third-trimester initiation of antiviral agents can reduce the risk of vertical transmission. We aimed to assess obstetricians' and gynecologists' (OB-GYN) knowledge and clinical practice when treating pregnant women with chronic hepatitis B virus (HBV). Methods: All program directors (PDs) from 250 US OB-GYN residency programs were invited to anonymously complete an 18-item questionnaire. Descriptive statistics were calculated and analyzed...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29116050/real-world-evidence-for-nucleoside-nucleotide-analogues-in-a-5-year-multicentre-study-of-antiviral-naive-chronic-hepatitis-b-patients-in-china-52-week-results
#20
Jidong Jia, Hong Tang, Qin Ning, Jiaji Jiang, Xiaoguang Dou, Mingxiang Zhang, Shuqin Zhang, Jia Shang, Wei Lu, Yinong Ye, Xin Wang, Mingshu Li, Jie Liu, Qingyan Bo, Wenzhong Tan
BACKGROUND: In China, the clinical management of chronic hepatitis B (CHB) is complicated by the use of various nucleos(t)ide analogue (NUC) regimens in treatment-naïve patients, including NUCs with low genetic barriers to resistance, with/without add-on therapy and de novo NUC combinations. This longitudinal observational study therefore investigated the real-world clinical management and efficacy of NUC therapy in treatment-naïve CHB patients in China. METHODS: Treatment-naïve CHB patients initiated on NUC therapy were enrolled from 63 hospitals in tier-2 Chinese cities...
November 8, 2017: Antiviral Therapy
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