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https://www.readbyqxmd.com/read/28641350/-laparoscopic-assisted-mobilisation-and-resection-of-a-sacrococcygeal-teratoma-altman-type-iii
#1
Jan Gödeke, Veronika Engel, Oliver Münsterer
Objective This video is a step-by-step illustration of the laparoscopic-assisted mobilisation and resection of a sacrococcygeal teratoma Altman type III. Indication Laparoscopic supralevatory tumour mobilisation is an established method in selected centres and can be the initial step in approaching sacrococcygeal teratomas with an intrapelvic portion, facilitating a complete (R0) resection. Method Laparoscopic surgery is performed in supine position with a 5 mm umbilical trocar, a 5 mm trocar in the right upper abdomen, and two 3 mm trocars in the left middle and lower abdomen...
June 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28640942/polyfunctional-response-by-immtac-imcgp100-redirected-cd8-and-cd4-t-cells
#2
Caroline Boudousquie, Giovanna Bossi, Jacob M Hurst, Karolina A Rygiel, Bent K Jakobsen, Namir J Hassan
The success of immune system based cancer therapies depends on a broad immune response engaging a range of effector cells and mechanisms. Immune mobilising monoclonal TCRs against cancer (ImmTAC(™) molecules, fusion proteins consisting of a soluble, affinity enhanced TCR and an anti-CD3 scFv Ab) were previously shown to redirect CD8(+) and CD4(+) T cells against tumours. Here we present evidence that IMCgp100 (ImmTAC recognising a peptide derived from the melanoma-specific protein, gp100, presented by HLA-A*0201) efficiently redirects and activates effector and memory cells from both CD8(+) and CD4(+) repertoires...
June 22, 2017: Immunology
https://www.readbyqxmd.com/read/28634646/the-role-of-robotics-in-the-invasive-management-of-bladder-cancer
#3
REVIEW
Pramit Khetrapal, Wei Shen Tan, Benjamin Lamb, Melanie Tan, Hilary Baker, James Thompson, Ashwin Sridhar, John D Kelly, Tim Briggs
Robot-assisted radical cystectomy (RARC) has been adopted widely in many centres, owed largely to the success of robot-assisted laparoscopic prostatectomy (RALP). It aims to replicate the oncological outcomes of open radical cystectomy (ORC), while providing a shorter recovery period. Despite this, previous RCTs have failed to show a benefit for RARC over ORC. These trials have compared extracorporeal RARC (eRARC) with ORC, which requires a further incision to mobilise the bowel for urinary reconstruction with an open technique...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28634158/stem-cell-therapy-for-enhancement-of-bone-consolidation-in-distraction-osteogenesis-a-contemporary-review-of-experimental-studies
#4
Y Yang, S Lin, B Wang, W Gu, G Li
OBJECTIVES: Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results. METHODS: We hereby review the published literature on the use of MSCs in promoting bone consolidation during DO. RESULTS: Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28630761/partial-proximal-tibia-fractures
#5
Michael J Raschke, Christoph Kittl, Christoph Domnick
Partial tibial plateau fractures may occur as a consequence of either valgus or varus trauma combined with a rotational and axial compression component.High-energy trauma may result in a more complex and multi-fragmented fracture pattern, which occurs predominantly in young people. Conversely, a low-energy mechanism may lead to a pure depression fracture in the older population with weaker bone density.Pre-operative classification of these fractures, by Müller AO, Schatzker or novel CT-based methods, helps to understand the fracture pattern and choose the surgical approach and treatment strategy in accordance with estimated bone mineral density and the individual history of each patient...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28630087/paucimannose-rich-n-glycosylation-of-spatiotemporally-regulated-human-neutrophil-elastase-modulates-its-immune-functions
#6
Ian Loke, Ole Østergaard, Niels H H Heegaard, Nicolle H Packer, Morten Thaysen-Andersen
Human neutrophil elastase (HNE) is an important N-glycosylated serine protease in the innate immune system, but the structure and immune-modulating functions of HNE N-glycosylation remain undescribed. Herein, LC-MS/MS-based glycan, glycopeptide and glycoprotein profiling were utilised to first determine the heterogeneous N-glycosylation of HNE purified from neutrophil lysates and then from isolated neutrophil granules of healthy individuals. The spatiotemporal expression of HNE during neutrophil activation and the biological importance of its N-glycosylation were also investigated using immunoblotting, cell surface capture, native MS, receptor interaction, protease inhibition, and bacteria growth assays...
June 19, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28627883/mechanism-of-vanadium-leaching-during-surface-weathering-of-basic-oxygen-furnace-steel-slag-blocks-a-%C3%A2%C2%B5xanes-and-sem-study
#7
Andrew James Hobson, Douglas I Stewart, Andrew William Bray, Robert J G Mortimer, William Matthew Mayes, Michael Rogerson, Ian T Burke
Basic oxygen furnace (BOF) steelmaking slag is enriched in potentially toxic V which may become mobilised in high pH leachate during weathering. BOF slag was weathered under aerated and air-excluded conditions for 6 months prior to SEM/EDS and µXANES analysis to determine V host phases and speciation in both primary and secondary phases. Leached blocks show development of an altered region in which free lime and dicalcium silicate phases were absent and Ca-Si-H was precipitated (CaCO3 was also present under aerated conditions)...
June 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28627070/lack-of-immunogenicity-of-hydrolysed-wheat-flour-in-patients-with-coeliac-disease-after-a-short-term-oral-challenge
#8
R Mandile, S Picascia, C Parrella, A Camarca, M Gobbetti, L Greco, R Troncone, C Gianfrani, R Auricchio
BACKGROUND: A gluten-free diet is currently the only reliable therapeutic strategy that is approved for coeliac disease (CD). For many patients, however, compliance remains inadequate. AIM: To investigate the immunogenicity of wheat flour that was pre-treated with selected lactobacilli and fungal proteases (hydrolysed wheat gluten) in coeliac patients. METHODS: The immunogenicity of hydrolysed wheat gluten was evaluated both in vitro in intestinal T cell lines (TCLs) and in vivo in treated CD patients after a short-term gluten challenge...
June 19, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28627017/functional-expression-of-calcium-permeable-canonical-transient-receptor-potential-4-containing-channels-promotes-migration-of-medulloblastoma-cells
#9
Wei-Chun Wei, Wan-Chen Huang, Yu-Ping Lin, Esther B E Becker, Olaf Ansorge, Veit Flockerzi, Daniele Conti, Giovanna Cenacchi, Maike D Glitsch
Aberrant intracellular Ca(2+) signalling contributes to the formation and progression of a range of distinct pathologies including cancers. Rises in intracellular Ca(2+) concentration occur in response to Ca(2+) influx through plasma membrane channels and Ca(2+) release from intracellular Ca(2+) stores, which can be mobilised in response to activation of cell surface receptors. OGR1 (Ovarian cancer G protein coupled Receptor 1, aka GPR68) is a proton-sensing Gq -coupled receptor that is most highly expressed in cerebellum...
June 19, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28623570/enhanced-recovery-protocols-in-total-joint-arthroplasty-a-review-of-the-literature-and-their-implementation
#10
REVIEW
A S Galbraith, E McGloughlin, J Cashman
BACKGROUND: During recent years, there has been an exponential demand for joint arthroplasty, which has coincided with the global economic recession. In response, the management of patients following arthroplasty is continuously evolving, with the average inpatient length of stay decreasing from weeks to days, and more recently, we have witnessed the development of "outpatient arthroplasty" as a novel concept which aims to address the high volume of patients. The reduction in length of stay has been made possible via implementation of "enhanced recovery programmes" encompassing each stage of the patient journey...
June 16, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28622466/dissolved-co2-increases-breakthrough-porosity-in-natural-porous-materials
#11
Yi Yang, Stefan Bruns, Susan Louise Svane Stipp, Henning Osholm Sørensen
When reactive fluids flow through a dissolving porous medium, conductive channels form, leading to fluid breakthrough. This phenomenon is caused by the reactive infiltration instability and is important in geologic carbon storage where the dissolution of CO2 in flowing water increases fluid acidity. Using numerical simulations with high resolution digital models of North Sea chalk, we show that the breakthrough porosity is an important indicator of dissolution pattern. Dissolution patterns reflect the balance between the demand and supply of cumulative surface...
June 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28619230/innovative-financing-instruments-for-global-health-2002-15-a-systematic-analysis
#12
Rifat Atun, Sachin Silva, Felicia M Knaul
Development assistance for health (DAH), the value of which peaked in 2013 and fell in 2015, is unlikely to rise substantially in the near future, increasing reliance on domestic and innovative financing sources to sustain health programmes in low-income and middle-income countries. We examined innovative financing instruments (IFIs)-financing schemes that generate and mobilise funds-to estimate the quantum of financing mobilised from 2002 to 2015. We identified ten IFIs, which mobilised US$8·9 billion (2·3% of overall DAH) in 2002-15...
July 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28605003/outcomes-of-gluteus-maximus-and-tensor-fascia-lata-transfer-for-primary-deficiency-of-the-abductors-of-the-hip
#13
Sivashankar Chandrasekaran, Nader Darwish, S Pavan Vemula, Parth Lodhia, Carlos Suarez-Ahedo, Benjamin G Domb
PURPOSE: This study aims to present 3 patients' results after undergoing gluteus maximus and tensor fascia lata (TFL) transfer for chronic abductor tears unable to be repaired primarily. METHODS: 3 patients were identified intraoperatively as having an abductor tear unable to be repaired primarily. The anterior 1/3 of the gluteus maximus and the posterior 1/3 of the TFL were mobilised and transferred to the greater trochanter in order to reproduce the normal force vector of the gluteus medius and minimus...
June 6, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28603550/health-system-governance-to-support-scale-up-of-mental-health-care-in-ethiopia-a-qualitative-study
#14
Charlotte Hanlon, Tigist Eshetu, Daniel Alemayehu, Abebaw Fekadu, Maya Semrau, Graham Thornicroft, Fred Kigozi, Debra Leigh Marais, Inge Petersen, Atalay Alem
BACKGROUND: Ethiopia is embarking upon a ground-breaking plan to address the high levels of unmet need for mental health care by scaling up mental health care integrated within primary care. Health system governance is expected to impact critically upon the success or otherwise of this important initiative. The objective of the study was to explore the barriers, facilitators and potential strategies to promote good health system governance in relation to scale-up of mental health care in Ethiopia...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28601436/evaluating-trace-element-bioavailability-and-potential-transfer-into-marine-food-chains-using-immobilised-diatom-model-species-phaeodactylum-tricornutum-on-king-george-island-antarctica
#15
Maria Teresa Cabrita, Ana Padeiro, Eduardo Amaro, Margarida Correia Dos Santos, Marcelo Leppe, Sergey Verkulich, Kevin A Hughes, Hans-Ulrich Peter, João Canário
In order to evaluate trace element bioavailability and potential transfer into marine food chains in human impacted areas of the Fildes Peninsula (King George Island, South Shetland Islands Archipelago), element levels (Cr, Ni, Cu, Zn, Cd, and Pb) were determined in water, sediments, phytoplankton, and in diatom Phaeodactylum tricornutum Bohlin (Bacillariophyceae) cells immobilised in alginate and exposed to water and sediments, from the Bellingshausen Dome (reference site) and Ardley Cove (human impacted area), during January 2014...
June 7, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28596976/endogenous-brain-repair-overriding-intrinsic-lineage-determinates-through-injury-induced-micro-environmental-signals
#16
Kathryn S Jones, Bronwen Connor
Adult human neurogenesis has generated excitement over the last 2 decades with the idea that endogenous adult stem cells could act as a potential cell source for brain repair after injury. Indeed, many forms of experimentally induced brain injury including stroke and excitotoxic lesioning can promote proliferation from the subventricular zone and mobilise neuroblasts and oligodendrocyte progenitor cells to migrate through brain parenchyma to damaged regions. However the failure of neuroblasts to mature into appropriate neuronal subtypes for cell replacement has been an issue...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28592848/metal-biogeochemistry-in-constructed-wetlands-based-on-fluviatile-sand-and-zeolite-and-clinopyroxene-dominated-lava-sand
#17
Jen-How Huang, Sonja Paul, Silke Mayer, Eloise Moradpour, Ralf Hasselbach, Reto Gieré, Christine Alewell
For the first time, speciation of Fe, Mn, Zn, Ni, Cu and Pb was determined along the profiles of 8 constructed wetlands (CWs) consisting of fluviatile sand (Fluv), clinopyroxene-dominated lava sand (Cl-LS) and zeolite-dominated lava sand (Ze-LS), aiming at quantifying metal behaviour in CWs and the impact caused by different filter materials. With the exception of Mn, which underwent reductive dissolution, CWs were sinks for the studied metals. Metal accumulation rates differed in the following order: Ze-LS ≥ Cl-LS > Fluv CWs, reflecting the highest metal adsorption capacity and the lowest hydraulic conductivity of Ze-LS...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28589806/mobility-care
#18
Rose Gallacher
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? I read the article because it was relevant to my practice as a nurse on a surgical unit, where many of the patients are older people. I wanted to improve my understanding of what an integrated approach to mobility care for older people might entail. The article stated that although this approach is aimed at older people living in nursing homes or residential care who require assistance with mobilising, it could also be applied to other care settings...
June 7, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28589273/synoptic-sampling-and-principal-components-analysis-to-identify-sources-of-water-and-metals-to-an-acid-mine-drainage-stream
#19
Patrick Byrne, Robert L Runkel, Katherine Walton-Day
Combining the synoptic mass balance approach with principal components analysis (PCA) can be an effective method for discretising the chemistry of inflows and source areas in watersheds where contamination is diffuse in nature and/or complicated by groundwater interactions. This paper presents a field-scale study in which synoptic sampling and PCA are employed in a mineralized watershed (Lion Creek, Colorado, USA) under low flow conditions to (i) quantify the impacts of mining activity on stream water quality; (ii) quantify the spatial pattern of constituent loading; and (iii) identify inflow sources most responsible for observed changes in stream chemistry and constituent loading...
June 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28589022/developing-an-expanded-vector-control-toolbox-for-malaria-elimination
#20
Gerry F Killeen, Allison Tatarsky, Abdoulaye Diabate, Carlos J Chaccour, John M Marshall, Fredros O Okumu, Shannon Brunner, Gretchen Newby, Yasmin A Williams, David Malone, Lucy S Tusting, Roland D Gosling
Vector control using long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) accounts for most of the malaria burden reductions achieved recently in low and middle-income countries (LMICs). LLINs and IRS are highly effective, but are insufficient to eliminate malaria transmission in many settings because of operational constraints, growing resistance to available insecticides and mosquitoes that behaviourally avoid contact with these interventions. However, a number of substantive opportunities now exist for rapidly developing and implementing more diverse, effective and sustainable malaria vector control strategies for LMICs...
March 2017: BMJ Global Health
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