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https://www.readbyqxmd.com/read/29138752/the-effect-of-granulocyte-colony-stimulating-factor-on-the-progression-of-atherosclerosis-in-animal-models-a-meta-analysis
#1
REVIEW
Manli Liu, Kejian Liu, Dongdong Chen, Hongzhi Chen, Kunming Sun, Xinxin Ju, Jiaojiao Lan, Yang Zhou, Weishan Wang, Lijuan Pang
Background: Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29134690/faecal-calcium-excretion-does-not-decrease-during-long-term-feeding-of-a-low-calcium-diet-in-adult-dogs
#2
S Schmitt, J Mack, E Kienzle, L G Alexander, P J Morris, A Colyer, B Dobenecker
According to a previous meta-analysis, adult dogs do not notably increase calcium absorption from the gastrointestinal tract when calcium intake is decreased. This results in a negative calcium balance even with a moderate calcium reduction. In this study we wanted to verify (i) whether a negative calcium balance occurs at a calcium intake equivalent to NRC (2006) (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC) minimal requirements, and if so (ii) whether the negative calcium balance will persist for up to 6 months on a low-calcium diet...
November 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29128687/translational-mobilisation-theory-a-new-paradigm-for-understanding-the-organisational-elements-of-nursing-work
#3
Davina Allen
Translational Mobilisation Theory (TMT) is a generic sociological theory that explains how emergent projects of collective action are progressed in complex organisational contexts. Grounded in a substantial programme of research on healthcare work, it has value for understanding the organisational component of the nursing role for educational, practice and research purposes. This paper introduces Translational Mobilisation Theory, outlines its core components, and considers its application to nursing using ethnographic research on the organising work of nurses as an empirical reference...
November 9, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29123562/the-role-of-occupational-and-physiotherapy-in-multi-modal-approach-to-tackling-delirium-in-the-intensive-care
#4
REVIEW
Jenny Rains, Nigel Chee
The presence of delirium within critical care remains a long-standing challenge for patients and clinicians alike. A myriad of pre-disposing and precipitating factors lead to this patient cohort being high risk for developing delirium during their critical care stay. Until now, non-pharmacological management of these patients usually encompasses a 'bundle' of principles to reduce delirium days. These bundles have limited focus on the entire multi-disciplinary team (including occupational therapists and physiotherapists) who could assist with the reduction of delirium...
November 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/29122281/good-functional-outcome-in-patients-suffering-fragility-fractures-of-the-pelvis-treated-with-percutaneous-screw-stabilisation-assessment-of-complications-and-factors-influencing-failure
#5
Henrik Eckardt, Alexander Egger, Rebecca Maria Hasler, Christoph J Zech, Werner Vach, Norbert Suhm, Mario Morgenstern, Franziska Saxer
BACKGROUND: Low energy pelvic ring fractures in the elderly have traditionally been treated conservatively, a treatment with potential long-term complications and loss of self-independence. Percutaneous screw stabilisation of the posterior pelvic ring is a new treatment modality that enables immediate mobilisation. The aim of this study was to assess the functional outcome after sacroiliac stabilisation in the elderly. METHODS: All elderly patients with a surgically stabilised low energy pelvic fracture between 2010 and 2015 were included...
November 4, 2017: Injury
https://www.readbyqxmd.com/read/29114865/the-politics-of-nationalism-and-white-racism-in-the-uk
#6
Magne Flemmen, Mike Savage
This paper considers the contemporary significance of white racism and its association with nationalist sentiment amongst a cohort late middle aged white Britons, using survey responses and qualitative interviews from the 1958 National Child Development Study. We have shown that although overt racism is very limited, a substantial minority of white Britons display ambivalent feelings which have the potential to be mobilised in racist directions. We argue against the view that disadvantaged white working class respondents are especially xenophobic, and show that racist views are not strongly associated with social position...
November 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/29112542/european-guidelines-on-perioperative-venous-thromboembolism-prophylaxis-neurosurgery
#7
David Faraoni, Raquel Ferrandis, William Geerts, Matthew D Wiles
: Although there are numerous publications addressing venous thromboembolism and its prevention in neurosurgery, there are relatively few high-quality studies to guide decisions regarding thromboprophylaxis. In patients undergoing craniotomy, we recommend that if intermittent pneumatic compression (IPC) is used, it should be applied before the surgical procedure or on admission (Grade 1C). In craniotomy patients at particularly high risk for venous thromboembolism, we suggest considering the initiation of mechanical thromboprophylaxis with IPC preoperatively with addition of low molecular weight heparin (LMWH) postoperatively when the risk of bleeding is presumed to be decreased (Grade 2C)...
November 6, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29107114/cancer-chemoprevention-via-activation-of-proteostatic-modules
#8
Aimilia Sklirou, Eleni-Dimitra Papanagnou, Nikolas Fokialakis, Ioannis P Trougakos
Proteins carry out the majority of cellular functions and maintain cellular homeodynamics mostly by participating in multimeric assemblies that operate as protein machines. Proteome quality control is thus critical for cellular functionality, and it is carried out through the curating activity of the proteostasis network (PN). Key components of the PN are the protein synthesis and trafficking modules, the endoplasmic reticulum unfolded protein response, molecular chaperones, and the two main degradation machineries, namely the ubiquitin proteasome and autophagy lysosome pathways...
October 26, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29102436/a-comfortable-solution-to-tracheal-anastomosis-protection-tracheal-retention-sutures
#9
Sami Karapolat, Atila Turkyilmaz, Kubra Nur Seyis, Celal Tekinbas
Fixation of the chin to the anterior chest wall is the most commonly used method of reducing anastomotic tension following a segmental resection of the trachea and reconstruction with primary anastomosis. However, the sutures required for this method may lead to various organic and psychological problems. In five patients who underwent tracheal resection and primary anastomosis, retention sutures were placed on the proximal and distal-lateral edges of the anastomotic line rather than placing a Guardian chin stitch...
October 12, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29102202/changes-in-maternal-abdominal-subcutaneous-fat-layers-using-ultrasound-a-longitudinal-study
#10
Narelle Kennedy, Ann Quinton, Chris Brown, Michael John Peek, Ron Benzie, Ralph Nanan
BACKGROUND: Abdominal adiposity and subcutaneous fat (SF), an important endocrine organ for health outcomes, can be divided into two layers, superficial (SSAT) and deep subcutaneous adipose tissue (DSAT) each with a different histological and metabolic function. The aim was to investigate longitudinal changes in maternal abdominal SF thickness and its layers throughout pregnancy and post-partum within body mass index (BMI) categories. METHODS: A prospective longitudinal study of 214 women was performed measuring abdominal SF using ultrasound at 12-14(M1), 18-20(M2), 26-29(M3) and 33-36 weeks' gestation (M4) and 6-8 weeks post-partum...
November 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29101168/genetically-increased-angiotensin-i-converting-enzyme-alters-peripheral-and-renal-vascular-reactivity-to-angiotensin-ii-and-bradykinin-in-mice
#11
Catherine Chollet, Sandrine Placier, Christos Chatziantoniou, Annette Hus-Citharel, Nathalie Caron, Ronan Roussel, Francois Alhenc-Gelas, Nadine Bouby
Angiotensin 1-converting enzyme (ACE) levels in man are under strong genetic influence. Genetic variation in ACE has been linked to risk for, and progression of, cardiovascular and renal diseases. Causality has been documented in genetically modified mice but mechanisms underlying causality are not completely elucidated. To further document the vascular and renal consequences of a moderate genetic increase in ACE synthesis, we studied genetically modified mice carrying three copies of the ACE gene (3-copy mice) and littermate wild type animals (2-copy mice)...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29095945/remobilisation-of-phosphorus-fractions-in-rice-flag-leaves-during-grain-filling-implications-for-photosynthesis-and-grain-yields
#12
Kwanho Jeong, Cecile C Julia, Daniel L E Waters, Omar Pantoja, Matthias Wissuwa, Sigrid Heuer, Lei Liu, Terry J Rose
Phosphorus (P) is translocated from vegetative tissues to developing seeds during senescence in annual crop plants, but the impact of this P mobilisation on photosynthesis and plant performance is poorly understood. This study investigated rice (Oryza sativa L.) flag leaf photosynthesis and P remobilisation in a hydroponic study where P was either supplied until maturity or withdrawn permanently from the nutrient solution at anthesis, 8 days after anthesis (DAA) or 16 DAA. Prior to anthesis, plants received either the minimum level of P in nutrient solution required to achieve maximum grain yield ('adequate P treatment'), or received luxury levels of P in the nutrient solution ('luxury P treatment')...
2017: PloS One
https://www.readbyqxmd.com/read/29093935/music-performance-anxiety-in-classical-musicians-what-we-know-about-what-works
#13
Raluca Matei, Jane Ginsborg
When pursued professionally, the demands of musical training and performance can interfere with musicians' well-being and health. Music performance anxiety, while energising at optimal levels, impairs performance quality when excessive. A range of interventions has been explored to address it. However, the poor methodological quality of such studies and the complexity of this issue should mobilise further research resources in this direction.
May 2017: BJPsych Int
https://www.readbyqxmd.com/read/29092758/navigation-guided-resection-of-maxillary-tumours-the-accuracy-of%C3%A2-computer-assisted-surgery-in-terms-of-control-of-resection-margins%C3%A2-a-feasibility-study
#14
Achille Tarsitano, Francesco Ricotta, Gennaro Baldino, Giovanni Badiali, Angelo Pizzigallo, Valerio Ramieri, Piero Cascone, Claudio Marchetti
INTRODUCTION: Surgical treatment of maxillary tumours is often highly complex. The three-dimensional anatomy of the mid-face renders both correct intraoperative orientation and adequate oncological safety difficult to obtain. Recently, computer-assisted techniques and intraoperative navigation have been applied to oncological surgery treating head and neck cancer. However, only a few studies have explored whether preoperative virtual resection planning and intraoperative control of resection margins allow assessment of the surgical margins of the tumour...
September 30, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29079829/experiments-on-sublimating-carbon-dioxide-ice-and-implications-for-contemporary-surface-processes-on-mars
#15
L E Mc Keown, M C Bourke, J N McElwaine
Carbon dioxide is Mars' primary atmospheric constituent and is an active driver of Martian surface evolution. CO2 ice sublimation mechanisms have been proposed for a host of features that form in the contemporary Martian climate. However, there has been very little experimental work or quantitative modelling to test the validity of these hypotheses. Here we present the results of the first laboratory experiments undertaken to investigate if the interaction between sublimating CO2 ice blocks and a warm, porous, mobile regolith can generate features similar in morphology to those forming on Martian dunes today...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29075055/single-dose-preemptive-plerixafor-for-stem-cell-mobilization-for-asct-after-lenalidomide-based-therapy-in-multiple-myeloma-impact-in-resource-limited-setting
#16
Rajiv Kumar, Rajan Kapoor, Bhushan Asthana, Jasjit Singh, Tarun Verma, Rajesh Chilaka, N K Singh, Ajay Sharma, S Das, Velu Nair
Peripheral blood stem cell mobilization with cytokines for autologous stem cell transplant in multiple myeloma is adversely affected by initial induction therapy consisting of either Lenalidomide or cytotoxic drugs, with failure rates of up to 45%. The use of Plerixafor with G-CSF for PBSC mobilisation significantly improves the chances of a successful mobilization. Plerixafor is a costly therapy and increases the overall costs of ASCT which can affect the number of patients being taken up for ASCT in resource limited settings...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075023/no-clinical-quantifiable-benefits-between-non-surgical-and-surgical-endodontic-treatment
#17
Debra M Ferrailo, Analia Veitz-Keenan
Data sourcesThe authors searched the following electronic databases: the Cochrane Oral Health Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid and Embase Ovid. The US National Registry of Clinical Trials (ClinicalTrials.gov) and the World Health Organisation (WHO) International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions regarding language and publication date. The authors hand-searched the reference lists of the studies retrieved and key journals in the field of endodontics...
October 27, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29073462/implementing-early-mobilisation-in-the-intensive-care-unit-an-integrative-review
#18
REVIEW
Sonja Phelan, Frances Lin, Marion Mitchell, Wendy Chaboyer
BACKGROUND: The intensive care unit provides complex care for critically ill patients. Consequently, due to the nature of critical illness and the therapies administered in intensive care, patients are often on prolonged periods of bed rest with limited mobility. It has been recognised that mobilising critically ill patients is beneficial to patients' recovery, however implementing early mobility as a standard of care remains challenging in practice. OBJECTIVES: To identify the key factors that underpin successful implementation and sustainability of early mobilisation in adult intensive care units...
October 2, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29071148/minimally-invasive-basilic-vein-transposition-in-the-arm-or-forearm-for-autogenous-haemodialysis-access-a-less-morbid-alternative-to-the-conventional-technique
#19
Ankush Jairath, Abhishek Singh, Ravindra Sabnis, Arvind Ganpule, Mahesh Desai
OBJECTIVE: To devise a minimally invasive, less morbid yet effective alternative technique for basilic vein transposition (BVT) in the arm/forearm and to compare perioperative outcomes with the conventional technique. PATIENTS AND METHODS: Patients undergoing BVT in the last two years (June 2013 to June 2015) were included in the study and the results were analysed. All patients were preoperatively evaluated using colour Doppler ultrasonography performed by the operating surgeon himself...
June 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29068400/health-in-all-policies-in-south-australia-did-it-promote-and-enact-an-equity-perspective
#20
Helen van Eyk, Elizabeth Harris, Fran Baum, Toni Delany-Crowe, Angela Lawless, Colin MacDougall
Mobilising cross-sectoral action is helpful in addressing the range of social determinants that contribute to health inequities. The South Australian Health in All Policies (SA HiAP) approach was implemented from 2007 to stimulate cross-sector policy activity to address the social determinants of health to improve population wellbeing and reduce health inequities. This paper presents selected findings from a five year multi-methods research study of the SA HiAP approach and draws on data collected during interviews, observation, case studies, and document analysis...
October 25, 2017: International Journal of Environmental Research and Public Health
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