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https://www.readbyqxmd.com/read/28428892/a-comparison-of-earlier-and-enhanced-rehabilitation-of-mechanically-ventilated-patients-in-critical-care-compared-to-standard-care-rehab-study-protocol-for-a-single-site-randomised-controlled-feasibility-trial
#1
Catherine Snelson, Charlotte Jones, Gemma Atkins, James Hodson, Tony Whitehouse, Tonny Veenith, David Thickett, Emma Reeves, Aisling McLaughlin, Lauren Cooper, David McWilliams
BACKGROUND: Mortality from critical illness is improving, but survivors suffer from prolonged weakness and psychological and cognitive impairments. Maximising the recovery after critical illness has been highlighted as a research priority, especially in relation to an ageing population who present with higher rates of pre-morbid disability. Small studies have shown that starting rehabilitation early within the intensive care unit (ICU) improves short-term outcomes. Systematic reviews have highlighted the need for robust multicentre randomised controlled trials with longer term follow-up...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28427794/occurrence-of-a-novel-class-1-integron-harboring-qnrvc4-in-salmonella-rissen
#2
Sirirat Luk-In, Chaiwat Pulsrikarn, Aroon Bangtrakulnonth, Tanittha Chatsuwan, Wanla Kulwichit
We described qnrVC4 in S. Rissen 166ANSS50, a swine isolate, which was detected in the study on quinolone resistance mechanisms of nontyphoidal Salmonella in Thailand. The isolate was found to harbor a ̴17-kb non-conjugative plasmid carrying qnrVC4 within 8.91kb of a novel In4-like class 1 integron (In805). It contained the multi-drug resistance gene cassettes of qnrVC4-qacH4-aacA4-cmlA7-blaOXA-10-aadA1-dfrA14 and unusual 3'-CS of mobC-IS6100. This 1014-bp qnrVC4 cassette included with promoter (PqnrVC4: -35 TTGAGA and -10 TAGTCT) showed high homology with qnrVC4 in superintegron of V...
March 31, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28426760/regulation-of-proteinaceous-effector-expression-in-phytopathogenic-fungi
#3
REVIEW
Kar-Chun Tan, Richard P Oliver
Effectors are molecules used by microbial pathogens to facilitate infection via effector-triggered susceptibility or tissue necrosis in their host. Much research has been focussed on the identification and elucidating the function of fungal effectors during plant pathogenesis. By comparison, knowledge of how phytopathogenic fungi regulate the expression of effector genes has been lagging. Several recent studies have illustrated the role of various transcription factors, chromosome-based control, effector epistasis, and mobilisation of endosomes within the fungal hyphae in regulating effector expression and virulence on the host plant...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28425900/mobiliser-des-repr%C3%A3-sentations-ethnoculturelles-pour-expliquer-les-disparit%C3%A3-s-d%C3%A2-acc%C3%A3-s-aux-soins-de-sant%C3%A3-au-burkina-faso
#4
Loubna Belaid, Patrick Cloos, Valéry Ridde
OBJECTIFS: Cette étude vise à décrire la mobilisation des représentations ethnoculturelles par des agents et des gestionnaires de santé pour expliquer l'échec partiel d'une politique de santé maternelle et discuter des conséquences potentielles de ces représentations sur l'accès aux soins de santé des populations.MÉTHODES : Il s'agit d'une recherche qualitative de type socio-anthropologique mobilisant des entretiens approfondis, des discussions informelles, des observations non participantes menées dans les centres de santé et une analyse documentaire...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28415032/comparative-metabolome-analysis-of-wheat-embryo-and-endosperm-reveals-the-dynamic-changes-of-metabolites-during-seed-germination
#5
Caixia Han, Shoumin Zhen, Gengrui Zhu, Yanwei Bian, Yueming Yan
In this study, we performed the first comparative metabolomic analysis of the wheat embryo and endosperm during seed germination using GC-MS/MS. In total, 82 metabolites were identified in the embryo and endosperm. Principal component analysis (PCA), metabolite-metabolite correlation and hierarchical cluster analysis (HCA) revealed distinct dynamic changes in metabolites between the embryo and endosperm during seed germination. Generally, the metabolite changes in the embryo were much greater than those in the endosperm, suggesting that the embryo is more active than the endosperm during seed germination...
April 10, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28414783/acceptability-and-feasibility-of-early-infant-male-circumcision-for-hiv-prevention-in-malawi
#6
Charles Chilimampunga, Simeon Lijenje, Judith Sherman, Kelvin Nindi, Webster Mavhu
BACKGROUND: Voluntary medical male circumcision (VMMC) has been successfully implemented in 14 countries as an additional HIV prevention intervention. As VMMC programs mature in most countries, the focus is now on how to sustain the HIV prevention gains realised from VMMC. As part of preparations for the sustainability phase, countries are either piloting or preparing to pilot early infant male circumcision (EIMC). This qualitative study explored the acceptability and feasibility of EIMC in Malawi in order to inform pilot implementation...
2017: PloS One
https://www.readbyqxmd.com/read/28405691/-customised-early-mobilisation-how-about-a%C3%A2-little-bit-more
#7
S Nessizius
Early mobilisation of patients in intensive care starts in a multiprofessional team with passive techniques continuing with assistive measures and finally going on to active training including mobilisation leading to sitting and standing positions as well as walking. Positive effects regarding these procedures have been proved in numerous studies and can also be found in the revision of the S2e guideline "Positioning and early mobilisation in prophylaxis or therapy of pulmonary disorders". In order to work with regard to the resources of the patient in intensive care, of the multiprofessional team, of the ward-specific structures and of the used equipment it is vital to apply a customised mobilisation concept...
April 12, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28400664/enhanced-recovery-protocol-and-hidden-blood-loss-in-patients-undergoing-total-knee-arthroplasty
#8
Rohit Dhawan, Harshadkumar Rajgor, Rathan Yarlagadda, John John, Niall M Graham
BACKGROUND: Perioperative blood loss and postoperative pain following total knee arthroplasty prevent early mobilisation of patients. The Enhanced Recovery Protocol (ERP) followed for patients in our institute aims at reducing post operative pain, blood loss and length of stay. MATERIALS AND METHODS: 50 consecutive patients that underwent ERP following total knee arthroplasty with another group of 70 patients that underwent the same surgery without ERP were compared in terms of hidden blood loss and length of hospital stay...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28397112/cell-therapy-for-multiple-sclerosis
#9
REVIEW
Pamela Sarkar, Claire M Rice, Neil J Scolding
Cell therapy is considered a promising potential treatment for multiple sclerosis, perhaps particularly for the progressive form of the disease for which there are currently no useful treatments. Over the past two decades or more, much progress has been made in understanding the biology of MS and in the experimental development of cell therapy for this disease. Three quite distinct forms of cell therapy are currently being pursued. The first seeks to use stem cells to replace damaged myelin-forming oligodendrocytes within the CNS; the second aims, in effect, to replace the individual's misfunctioning immune system, making use of haematopoietic stem cells; and the third seeks to utilise endogenous stem cell populations by mobilisation with or without in vitro expansion, exploiting their various reparative and neuroprotective properties...
April 10, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28392636/subcutaneous-emphysema-after-shoulder-arthroscopy-a-case-report-and-review-of-the-literature
#10
Els S M Van Nieuwenhuyse, Bart Kerens, Jan Moens, Gunther Kiekens
INTRODUCTION: Subcutaneous emphysema (SE) and pneumomediastinum are rare complications after shoulder arthroscopy. CASE REPORT: A case is presented in which SE was seen after arthroscopic cuff repair. DISCUSSION: A review of current literature shows that SE after shoulder arthroscopy can be due to loco-regional anaesthesiology, endotracheal intubation, gas-forming infection, postoperative mobilisation or the arthroscopic procedure itself. During the procedure air can be sucked into the subacromial space due to suction and subsequently transferred into subcutaneous tissue by the positive pressure of the infusion pump...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28388937/advancing-engagement-methods-for-trials-the-core-study-relational-model-of-engagement-for-a-stepped-wedge-cluster-randomised-controlled-trial-of-experience-based-co-design-for-people-living-with-severe-mental-illnesses
#11
Lauralie Richard, Donella Piper, Wayne Weavell, Rosemary Callander, Rick Iedema, John Furler, David Pierce, Kali Godbee, Jane Gunn, Victoria J Palmer
BACKGROUND: Engagement is essential in trials research but is rarely embedded across all stages of the research continuum. The development, use, effectiveness and value of engagement in trials research is poorly researched and understood, and models of engagement are rarely informed by theory. This article describes an innovative methodological approach for the development and application of a relational model of engagement in a stepped wedge designed cluster randomised controlled trial (RCT), the CORE study...
April 8, 2017: Trials
https://www.readbyqxmd.com/read/28387658/do-turkish-patients-with-lumbar-disc-herniation-know-body-mechanics
#12
Sacide Yildizeli Topcu
BACKGROUND AND OBJECTIVE: Most common and important cause of the low back pain is lumbar disc herniation. Patients with lumbar disc herniation face with difficulties during daily activities due to the reduction of physical functions. In order to maintain daily activities without pain and discomfort, the patients should be informed about proper positions and body mechanics. The aim of the study was to determine the knowledge and the applications of the patients with lumbar disc herniation about body mechanics...
March 31, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28385477/espen-guideline-clinical-nutrition-in-surgery
#13
Arved Weimann, Marco Braga, Franco Carli, Takashi Higashiguchi, Martin Hübner, Stanislaw Klek, Alessandro Laviano, Olle Ljungqvist, Dileep N Lobo, Robert Martindale, Dan L Waitzberg, Stephan C Bischoff, Pierre Singer
Early oral feeding is the preferred mode of nutrition for surgical patients. Avoidance of any nutritional therapy bears the risk of underfeeding during the postoperative course after major surgery. Considering that malnutrition and underfeeding are risk factors for postoperative complications, early enteral feeding is especially relevant for any surgical patient at nutritional risk, especially for those undergoing upper gastrointestinal surgery. The focus of this guideline is to cover nutritional aspects of the Enhanced Recovery After Surgery (ERAS) concept and the special nutritional needs of patients undergoing major surgery, e...
March 7, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28372979/the-use-of-flow-cytometry-to-examine-calcium-signalling-by-trpv1-in-mixed-cell-populations
#14
Bakri M Assas, Wesam H Abdulaal, Majed H Wakid, Haytham A Zakai, J Miyan, J L Pennock
Flow cytometric analysis of calcium mobilisation has been in use for many years in the study of specific receptor engagement or isolated cell:cell communication. However, calcium mobilisation/signaling is key to many cell functions including apoptosis, mobility and immune responses. Here we combine multiplex surface staining of whole spleen with Indo-1 AM to visualise calcium mobilisation and examine calcium signaling in a mixed immune cell culture over time. We demonstrate responses to a TRPV1 agonist in distinct cell subtypes without the need for cell separation...
March 31, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28372742/an-optimised-sequential-extraction-scheme-for-the-evaluation-of-vanadium-mobility-in-soils
#15
Yu-Hui Xu, Jen-How Huang, Helmut Brandl
Reviewing the current state of knowledge about sequential extraction applied for soil vanadium (V) fractionation, we identified an urgent requirement of an sequential extraction (SE) specified for V. Namely, almost all previous SE extracted only 8.4%-48% of total V in soils (excluding residue). Thus, we proposed an eight-step SE for V fractionation in soils according to the knowledge gained from literature and our own dissolution experiments with model minerals. After extracting the mobilisable and adsorbed V with de-ionised water and 5mmol/L phosphate, 1mol/L pyrophosphate was applied to gather organic matter bound V which minimised the artefact dissolving Al and Fe (hydr)oxides occurred when using HNO3-H2O2 for extraction...
March 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28372479/building-a-regional-health-agenda-a-rights-based-approach-to-health-in-south-america
#16
María Belén Herrero, Jorgelina Loza
Attention to health policies in Southern regional organisations reveals a new 'social turn' in the regional political economy of international cooperation. The aims of this paper are twofold. First, it aims to establish the extent to which the Union of South American Nations (UNASUR) has adopted and sustained policy interventions committed to addressing social inequities and asymmetries in relation to health, as indicated by regional policy agendas, policy development processes and resourcing. Second, it seeks to understand how UNASUR is mobilising national and regional actors in support of such policies...
April 3, 2017: Global Public Health
https://www.readbyqxmd.com/read/28369486/redefining-public-health-leadership-in-the-sustainable-development-goal-era
#17
K Srinath Reddy, Manu Raj Mathur, Sagri Negi, Bhargav Krishna
Adoption of the Sustainable Development Goals (SDGs) by member states of the United Nations (UN) has set a new agenda for public health action at national and global levels. The changed context calls for a reframing of what constitutes effective leadership in public health, through a construct that reflects the interdependence of leadership at multiple levels across the health system and its partners in other sectors. This is especially important in the context of Low and Middle Income Countries (LMICs) that are facing complex demographic and epidemiological transitions...
March 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28366260/-the-wounds-of-people-receiving-end-of-life-palliative-care
#18
REVIEW
Odile Martinet, Idriss Farota-Romejko
When it includes the care of wounds, the management of patients at the end of life mobilises caregivers around a care project which brings together therapeutic, technical and relational challenges. In partnership with the patient and their families, the care must be adjusted and respectful of the patient's progression.
April 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28365513/relationships-between-soil-parameters-and-physiological-status-of-miscanthus-x-giganteus-cultivated-on-soil-contaminated-with-trace-elements-under-npk-fertilisation-vs-microbial-inoculation
#19
Marta Pogrzeba, Szymon Rusinowski, Krzysztof Sitko, Jacek Krzyżak, Aleksandra Skalska, Eugeniusz Małkowski, Dorota Ciszek, Sebastian Werle, Jon Paul McCalmont, Michal Mos, Hazem M Kalaji
Crop growth and development can be influenced by a range of parameters, soil health, cultivation and nutrient status all play a major role. Nutrient status of plants can be enhanced both through chemical fertiliser additions (e.g. N, P, K supplementation) or microbial fixation and mobilisation of naturally occurring nutrients. With current EU priorities discouraging the production of biomass on high quality soils there is a need to investigate the potential of more marginal soils to produce these feedstocks and the impacts of soil amendments on crop yields within them...
March 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28361966/ash-aggregation-enhanced-by-deposition-and-redistribution-of-salt-on-the-surface-of-volcanic-ash-in-eruption-plumes
#20
Sebastian B Mueller, Paul M Ayris, Fabian B Wadsworth, Ulrich Kueppers, Ana S Casas, Pierre Delmelle, Jacopo Taddeucci, Michael Jacob, Donald B Dingwell
Interactions with volcanic gases in eruption plumes produce soluble salt deposits on the surface of volcanic ash. While it has been postulated that saturation-driven precipitation of salts following the dissolution of ash surfaces by condensed acidic liquids is a primary mechanism of salt formation during an eruption, it is only recently that this mechanism has been subjected to detailed study. Here we spray water and HCl droplets into a suspension of salt-doped synthetic glass or volcanic ash particles, and produce aggregates...
March 31, 2017: Scientific Reports
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