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https://www.readbyqxmd.com/read/29683947/encephalocraniocutaneous-lipomatosis
#1
Abhishek Bavle, Rikin Shah, Naina Gross, Theresa Gavula, Alejandro Ruiz-Elizalde, Klaas Wierenga, Rene McNall-Knapp
A 5-year-old boy presented with worsening headaches for 3 months. On examination, he was found to have a hairless fatty tissue nevus of the scalp (nevus psiloliparus), subcutaneous soft tissue masses on the right side of his face, neck, mandible and right buttock and epibulbar dermoid of the right eye (choristoma) (Figs. 1A, B). Magnetic resonance imaging revealed a large suprasellar mass, which was debulked and found to be a pilocytic astrocytoma. Testing was not performed for the BRAF/KIAA1549 fusion or BRAFV600E mutation...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29682361/recurrent-ameloblastoma-a-surgical-challenge
#2
Chithra Aramanadka, Abhay Taranath Kamath, Adarsh Kudva
Ameloblastoma is locally aggressive benign odontogenic tumour with increased risk of recurrence rate. The choice of treatment depends on the histologic subtype. Radical therapy is the recommended modality for solid ameloblastomas. The possibilities of recurrence even after enbloc resection are still high. The author presents two case reports of recurrent ameloblastomas postradical resection. First case describes the recurrence of ameloblastoma in the bone graft which was used for reconstruction, and the second case depicts recurrence in the infratemporal fossa...
2018: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29682023/extraosseous-primary-intracranial-ewing-sarcoma-peripheral-primitive-neuroectodermal-tumor-series-of-seven-cases-and-review-of-literature
#3
Amit Kumar Singh, Arun Kumar Srivastava, Lily Pal, Jayesh Sardhara, Rajan Yadav, Shalini Singh, Kamlesh Singh Bhaisora, Kuntal Kanti Das, Anant Mehrotra, Rabi Narayan Sahu, Awadhesh Kumar Jaiswal, Sanjay Behari
Background: The Ewing sarcoma peripheral PNET (ES-pPNET) is very rare small round cell tumour that involves the CNS as either a primary dural neoplasm or by direct extension from contiguous bone or soft tissue. Materials and Methods: Biopsy proven cases of intracranial ES/pPNET with orbital involvement operated during Jan 2010-Jan 2014 were retrospectively included and their clinical data, operative and histological findings were reviewed from institutional oncology register...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681762/correlation-of-high-risk-soft-tissue-sarcoma-biomarker-expression-patterns-with-outcome-following-neoadjuvant-chemoradiation
#4
John M Kane, Anthony Magliocco, Qiang Zhang, Dian Wang, Alex Klimowicz, Jonathan Harris, Jeff Simko, Thomas DeLaney, William Kraybill, David G Kirsch
Background: Sarcoma mortality remains high despite adjuvant chemotherapy. Biomarker predictors of treatment response and outcome could improve treatment selection. Methods: Tissue microarrays (TMAs) were created using pre- and posttreatment tumor from two prospective trials (MGH pilot and RTOG 9514) of neoadjuvant/adjuvant MAID chemotherapy and preoperative radiation. Biomarkers were measured using automated computerized imaging (AQUA or ACIS). Expression was correlated with disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS)...
2018: Sarcoma
https://www.readbyqxmd.com/read/29680487/spectrum-of-chronic-complications-related-to-silicone-leakage-and-migration
#5
Alexander J Ryu, Katrina N Glazebrook, Naziya Samreen, Philippe R Bauer, Eunhee S Yi, Jay H Ryu
BACKGROUND: Medical silicone is widely used as implants and free injections but the spectrum of complications related to migration or embolization of silicone remains unclear. METHODS: We retrospectively reviewed 79 patients with silicone migration as confirmed on pathology between January 1, 2001 and December 31, 2016. The presenting clinical and imaging features, diagnostic testing, treatment, and outcome were assessed. RESULTS: Nearly all were women and 43% had a history of breast cancer...
April 19, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29679383/shortened-courses-of-antibiotics-for-bacterial-infections-a-systematic-review-of-randomized-controlled-trials
#6
Alexandra M Hanretty, Jason C Gallagher
BACKGROUND: Commonly prescribed durations of therapy for many, if not most, bacterial infections are not evidence-based. Misunderstandings by clinicians and patients alike influence perspectives on antibiotic use, including duration of therapy and its role in antibiotic resistance. OBJECTIVE: To demonstrate that shorter durations of antibiotic therapy are as efficacious as longer durations for many infections. DATA SOURCES: A systematic review of English language articles using PubMed were identified for inclusion...
April 20, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29679255/needle-tissue-interactive-mechanism-and-steering-control-in-image-guided-robot-assisted-minimally-invasive-surgery-a-review
#7
Pan Li, Zhiyong Yang, Shan Jiang
Image-guided robot-assisted minimally invasive surgery is an important medicine procedure used for biopsy or local target therapy. In order to reach the target region not accessible using traditional techniques, long and thin flexible needles are inserted into the soft tissue which has large deformation and nonlinear characteristics. However, the detection results and therapeutic effect are directly influenced by the targeting accuracy of needle steering. For this reason, the needle-tissue interactive mechanism, path planning, and steering control are investigated in this review by searching literatures in the last 10 years, which results in a comprehensive overview of the existing techniques with the main accomplishments, limitations, and recommendations...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29676166/the-need-for-and-implementation-of-image-guidance-in-radiation-therapy
#8
G S Ibbott
The introduction of image guidance in radiation therapy and its subsequent innovations have revolutionised the delivery of cancer treatment. Modern imaging systems can supplement and often replace the historical practice of relying on external landmarks and laser alignment systems. Rather than depending on markings on the patient's skin, image-guided radiation therapy (IGRT), using techniques such as computed tomography (CT), cone beam CT, MV on-board imaging (OBI), and kV OBI, allows the patient to be positioned based on the internal anatomy...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29675986/efficacy-and-safety-of-extracorporeal-shock-wave-therapy-for-acute-and-chronic-soft-tissue-wounds-a-systematic-review-and-meta-analysis
#9
Li Zhang, Xiao-Bing Fu, Shuo Chen, Zhan-Bo Zhao, Christoph Schmitz, Chang-Shui Weng
This study aimed to evaluate and compare the effects of extracorporeal shock wave therapy (ESWT) and conventional wound therapy (CWT) for acute and chronic soft tissue wounds. All English-language articles on ESWT for acute and chronic soft tissue wounds indexed in PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, Cochrane Library, Physiotherapy Evidence Database, and HealthSTAR published prior to June 2017 were included, as well as corresponding articles cited in reference lists of related review articles...
April 19, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29675364/ct-and-mri-of-superficial-solid-tumors
#10
REVIEW
Jingfeng Zhang, Yanyuan Li, Yilei Zhao, Jianjun Qiao
Superficial solid masses are common conditions in clinical practice, however, some of which can be easily diagnosed and others would be difficult. Although imaging of superficial masses is not always characteristic, it would be helpful to give a definitive diagnosis or narrow a differential diagnosis. Crossing-section imaging can depicture the masses directly, find some pathognomonic signs and demonstrate their relationship with adjacent structures, which can provide decision support for clinician's reference...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29673044/wedge-shaped-polydioxanone-threads-in-a-folded-configuration-solid-fillers-a-treatment-option-for-deep-static-wrinkles-on-the-upper-face
#11
Seung Hoon Kang, Seok Hoon Moon, Bong-Il Rho, Seong Jae Youn, Hei Sung Kim
BACKGROUND: Facial wrinkles are key signs of aging which affect one's quality of life and psychological well-being. Absorbable wedge-shaped polydioxanone (PDO) sutures are popular in the esthetic clinics of Korea and may be a treatment option for static wrinkles on the upper face. OBJECTIVE: To describe a novel technique applicable to deep static wrinkles on the upper face and to assess its safety and efficacy. PATIENTS AND METHODS: A retrospective chart review was performed on the static wrinkle cases which were treated with folded, wedge-shaped PDO threads...
April 19, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29672785/-tissue-engineering-of-adipose-tissue-with-biodegradable-biomaterials-for-soft-tissue-reconstruction
#12
Silvan Klein, Thiha Aung, Robert Michael Haas, Fabian Medved, Stefan M Schiller, Oliver Felthaus, Jürgen H Dolderer
Soft tissue defects resulting from injuries, tumor resection, congenital anomalies or chronic wounds pose a great challenge to reconstructive surgery. The current gold standard in therapy of such defects is the tissue transplantation in terms of free or local flaps. Unfortunately, donor site morbidity remains a considerable risk of flap surgery. Therefore, tissue engineering of autologous vascularized long term stable adipose tissue constructs could enrich the therapeutic possibilities of soft tissue defects...
April 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29671865/diabetes-and-necrotizing-soft-tissue-infections-a-prospective-observational-cohort-study-statistical-analysis-plan
#13
A Rosén, P Arnell, M B Madsen, B G Nedrebø, A Norrby-Teglund, O Hyldegaard, V M Dos Santos, F Bergey, E Saccenti, S Skrede
BACKGROUND: Necrotizing soft tissue infections (NSTIs) are rare but carry a high morbidity and mortality. The multicenter INFECT project aims to improve the understanding of the pathogenesis, clinical characteristics, diagnosis, and prognosis of NSTIs. This article describes the study outline and statistical analyses that will be used. METHODS: Within the framework of INFECT project, patients with NSTI at 5 Scandinavian hospitals are enrolled in a prospective observational cohort study...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29670334/aldoxorubicin-a-tumor-targeted-doxorubicin-conjugate-for-relapsed-or-refractory-soft-tissue-sarcomas
#14
REVIEW
Jun Gong, Jessica Yan, Charles Forscher, Andrew Hendifar
Despite available therapies after initial systemic therapy, prognosis remains poor in relapsed or refractory soft tissue sarcomas (STS). The rational and clinical development of novel agents to improve outcomes in this area of high unmet need is desperately warranted. Aldoxorubicin is a prodrug of doxorubicin that binds to serum albumin immediately after administration through an acid-sensitive hydrazone linker and is subsequently transported to tumor tissues where the acidic environment cleaves the linker and facilitates delivery of a tumor-targeted drug payload...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29670090/inhibition-of-cyclin-dependent-kinase-4-as-a-potential-therapeutic-strategy-for-treatment-of-synovial-sarcoma
#15
Xiaoyang Li, Nicole A Seebacher, Cassandra Garbutt, Hangzhan Ma, Peng Gao, Tao Xiao, Francis J Hornicek, Zhenfeng Duan
Synovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities of the arms or legs, for which current chemotherapeutic agents have not been proven to be very effective. The cyclin-dependent kinase 4/6-retinoblastoma protein (CDK4/6-Rb) pathway of cell cycle control is known to be aberrant in a large proportion of cancers. Recently, CDK4 inhibitors have successfully been used pre-clinically for the treatment of many human cancers, and in 2015, following the success of clinical trials, the FDA approved the first selective CDK4/6 inhibitor, palbociclib, for the treatment of endocrine therapy resistant breast cancers...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29667186/infectious-diseases-in-older-adults-of-long-term-care-facilities-update-on-approach-to-diagnosis-and-management
#16
REVIEW
Robin L P Jump, Christopher J Crnich, Lona Mody, Suzanne F Bradley, Lindsay E Nicolle, Thomas T Yoshikawa
The diagnosis, treatment, and prevention of infectious diseases in older adults in long-term care facilities (LTCFs), particularly nursing facilities, remains a challenge for all health providers who care for this population. This review provides updated information on the currently most important challenges of infectious diseases in LTCFs. With the increasing prescribing of antibiotics in older adults, particularly in LTCFs, the topic of antibiotic stewardship is presented in this review. Following this discussion, salient points on clinical relevance, clinical presentation, diagnostic approach, therapy, and prevention are discussed for skin and soft tissue infections, infectious diarrhea (Clostridium difficile and norovirus infections), bacterial pneumonia, and urinary tract infection, as well as some of the newer approaches to preventive interventions in the LTCF setting...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29667156/how-we-manage-patients-with-plasmacytomas
#17
REVIEW
Despina Fotiou, Meletios A Dimopoulos, Efstathios Kastritis
PURPOSE OF REVIEW: To discuss the diagnostic approach, treatment options, and future considerations in the management of plasmacytomas, either solitary or in the context of overt multiple myeloma (MM). RECENT FINDINGS: Advanced imaging techniques such as whole-body magnetic resonance imaging and positron emission tomography/computerized tomography are essential for the diagnostic workup of solitary plasmacytomas (SP) to rule out the presence of other disease foci...
April 17, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29667040/management-of-superficial-and-deep-seated-staphylococcus-aureus-skin-and-soft-tissue-infections-in-sub-saharan-africa-a-post-hoc-analysis-of-the-staphnet-cohort
#18
Abraham Alabi, Theckla Kazimoto, Marthe Lebughe, Delfino Vubil, Patrick Phaku, Inacio Mandomando, Winfried V Kern, Salim Abdulla, Alexander Mellmann, Lena Peitzmann, Markus Bischoff, Georg Peters, Mathias Herrmann, Martin P Grobusch, Frieder Schaumburg, Siegbert Rieg
PURPOSE: The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in the African setting and to identify challenges in the management. METHODS: Patients (n = 319) were recruited in DR Congo (n = 56, 17.6%), Gabon (n = 89, 27...
April 17, 2018: Infection
https://www.readbyqxmd.com/read/29665603/pain-in-osteochondral-lesions-of-the-ankle-an-investigation-based-on-data-from-the-german-cartilage-registry-knorpelregister-dgou
#19
Daniel Körner, Philipp Kohler, Steffen Schröter, Aline Naumann, Markus Walther, Philipp Niemeyer, Yannic Bangert, Matthias Aurich, Atesch Ateschrang
BACKGROUND: The aim of the study was to investigate parameters influencing the preoperative pain intensity in patients with osteochondral lesions of the ankle. The evaluation covered patient-related parameters such as age, sex, body mass index (BMI), as well as defect-related parameters, such as localisation, size and stage (according to the classification of the International Cartilage Repair Society [ICRS] and the Berndt-Harty-Loomer classification). We also examined the correlation between the different surgical techniques and additional factors, such as debridement of an impingement or stabilisation of the ankle on the one hand, and the preoperative pain intensity on the other...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29662775/relationship-between-heterotopic-ossification-and-traumatic-brain-injury-why-severe-traumatic-brain-injury-increases-the-risk-of-heterotopic-ossification
#20
REVIEW
Huan Huang, Wen-Xiang Cheng, Yi-Ping Hu, Jian-Hai Chen, Zheng-Tan Zheng, Peng Zhang
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence...
January 2018: Journal of Orthopaedic Translation
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