Xin-Fei Chen, Han Zhang, Ling-Li Liu, Li-Na Guo, Wen-Jing Liu, Ya-Li Liu, Ding-Ding Li, Ying Zhao, Ren-Yuan Zhu, Yi Li, Rong-Chen Dai, Shu-Ying Yu, Jin Li, Tong Wang, Hong-Tao Dou, Ying-Chun Xu
Candida auris, an emerging and multidrug-resistant fungal pathogen, has led to numerous outbreaks in China. While the resistance mechanisms against azole and amphotericin B have been studied, the development of drug resistance in this pathogen remains poorly understood, particularly in in vivo-generated drug-resistant strains. This study employed pathogen whole-genome sequencing to investigate the epidemiology and drug-resistance mutations of C. auris using 16 strains isolated from two patients. Identification was conducted through Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and antimicrobial susceptibilities were assessed using broth microdilution and Sensititre YeastOne YO10...
April 18, 2024: Mycopathologia