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https://www.readbyqxmd.com/read/28052468/young-people-with-type-1-diabetes-mellitus-attitudes-perceptions-and-experiences-of-diabetes-management-and-continuous-subcutaneous-insulin-infusion-therapy
#1
Lin Perry, Steven James, Katharine Steinbeck, Janet Dunbabin, Julia Lowe
RATIONALE, AIMS, AND OBJECTIVES: Continuous subcutaneous insulin infusion (CSII; insulin pump) use is increasing. However, there is little information about how this technology is used compared with other insulin delivery methods (ie, injections) by young people with type 1 diabetes mellitus in Australia. This study explored young people's attitudes, perceptions, and experiences with diabetes management comparing those using with those not using CSII, and proportions likely to transition to adult services requiring initiation and/or support for CSII use...
January 4, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28018888/health-care-for-children-with-diabetes-mellitus-from-low-income-families-in-ontario-and-california-a-population-based-cohort-study
#2
Sunitha V Kaiser, Vandana Sundaram, Eyal Cohen, Rayzel Shulman, Jun Guan, Lee Sanders, Astrid Guttmann
BACKGROUND: Children with diabetes mellitus in low-income families have poor outcomes, but little is known as to how this relates to healthcare system structure. Our objective was to gain insight into how best to structure health systems to serve these children by describing their health care use in 2 health system models: a Canadian model, with an organized diabetes care network that includes generalists, and an American model, with targeted support services for children from low-income families...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28008584/changes-in-quality-of-diabetes-care-and-morbidity-over-20-years-in-people-with-type-1-diabetes-and-long-diabetes-duration-the-jevin-trial
#3
T Heller, K Reise, J Roth, T Lehmann, R Schiel, S Lorkowski, U A Müller, N Müller
Background: The JEVIN trial started as a cross-sectional study in 1989/90 in Jena, a city of the former German Democratic Republic. At that time, the centralized diabetes care system was broken down and restarted 10 years later; structured treatment and teaching programs were implemented, blood glucose self-monitoring, insulin pump-systems and analogue insulin were introduced. We surveyed people with type-1-diabetes of the baseline JEVIN trial in a 20-year follow-up. Methods: 131 patients with type-1-diabetes were analyzed in 1989/90...
December 22, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28007348/home-use-of-a-bihormonal-bionic-pancreas-versus-insulin-pump-therapy-in-adults-with-type-1-diabetes-a-multicentre-randomised-crossover-trial
#4
Firas H El-Khatib, Courtney Balliro, Mallory A Hillard, Kendra L Magyar, Laya Ekhlaspour, Manasi Sinha, Debbie Mondesir, Aryan Esmaeili, Celia Hartigan, Michael J Thompson, Samir Malkani, J Paul Lock, David M Harlan, Paula Clinton, Eliana Frank, Darrell M Wilson, Daniel DeSalvo, Lisa Norlander, Trang Ly, Bruce A Buckingham, Jamie Diner, Milana Dezube, Laura A Young, April Goley, M Sue Kirkman, John B Buse, Hui Zheng, Rajendranath R Selagamsetty, Edward R Damiano, Steven J Russell
BACKGROUND: The safety and effectiveness of a continuous, day-and-night automated glycaemic control system using insulin and glucagon has not been shown in a free-living, home-use setting. We aimed to assess whether bihormonal bionic pancreas initialised only with body mass can safely reduce mean glycaemia and hypoglycaemia in adults with type 1 diabetes who were living at home and participating in their normal daily routines without restrictions on diet or physical activity. METHODS: We did a random-order crossover study in volunteers at least 18 years old who had type 1 diabetes and lived within a 30 min drive of four sites in the USA...
December 20, 2016: Lancet
https://www.readbyqxmd.com/read/28005249/runtime-verification-of-pacemaker-functionality-using-hierarchical-fuzzy-colored-petri-nets
#5
Negar Majma, Seyed Morteza Babamir, Amirhassan Monadjemi
Today, implanted medical devices are increasingly used for many patients and in case of diverse health problems. However, several runtime problems and errors are reported by the relevant organizations, even resulting in patient death. One of those devices is the pacemaker. The pacemaker is a device helping the patient to regulate the heartbeat by connecting to the cardiac vessels. This device is directed by its software, so any failure in this software causes a serious malfunction. Therefore, this study aims to a better way to monitor the device's software behavior to decrease the failure risk...
February 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28004007/clinical-efficacy-of-two-different-methods-to-initiate-sensor-augmented-insulin-pumps-a-randomized-controlled-trial
#6
Jesus Moreno-Fernandez, Francisco Javier Gómez, Maria Ángeles Gálvez Moreno, Justo P Castaño
Aim. To analyze clinical effect of a novel approach to initiate sensor-augmented insulin pumps in type 1 diabetes mellitus (T1DM) patients through early real-time continuous glucose monitoring (RT-CGM) initiation. Methods. A 26-week pilot study with T1DM subjects randomized (1 : 1) to start RT-CGM three weeks before continuous subcutaneous insulin infusion (CGM pre-CSII) or adding RT-CGM three weeks after continuous subcutaneous insulin infusion (CGM post-CSII). Results. Twenty-two patients were enrolled with a mean age of 36...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28001445/long-term-efficacy-and-safety-of-sensor-augmented-insulin-pump-therapy-with-low-glucose-suspend-feature-in-patients-with-type-1-diabetes
#7
Ana María Gómez, Lisseth Fernanda Marín Carrillo, Oscar Mauricio Muñoz Velandia, Martín Alonso Rondón Sepúlveda, Carol M Arévalo Correa, Edwin Mora Garzón, Maria Camila Cuervo Diaz, Diana Cristina Henao Carrillo
BACKGROUND: Literature supports short-term efficacy and safety of Sensor Augmented Insulin Pump (SAP) therapy in patients with type 1 diabetes (T1D). However, no data are available showing long-term outcomes. Our study describes the long-term outcomes of SAP therapy with low-glucose suspend feature (SAP+LGS) in hypoglycemia in a Colombian population with T1D and hypoglycemia. METHODS: A cohort study was conducted with T1D patients receiving SAP+LGS therapy who initiated this therapy because of hypoglycemia at San Ignacio University Hospital diabetes center in Bogotá, Colombia...
December 21, 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27996321/measures-of-glycemic-variability-in-type-1-diabetes-and-the-effect-of-real-time-continuous-glucose-monitoring
#8
Ahmed H El-Laboudi, Ian F Godsland, Desmond G Johnston, Nick S Oliver
OBJECTIVE: To report the impact of continuous glucose monitoring (CGM) on glycemic variability (GV) indices, factors predictive of change, and to correlate variability with conventional markers of glycemia. METHODS: Data from the JDRF study of CGM in participants with type 1 diabetes were used. Participants were randomized to CGM or self-monitored blood glucose (SMBG). GV indices at baseline, at 26 weeks in both groups, and at 52 weeks in the control group were analyzed...
December 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27989545/physical-activity-and-sedentary-behavior-levels-in-children-and-adolescents-with-type-1-diabetes-using-insulin-pump-or-injection-therapy-the-importance-of-parental-activity-profile
#9
Isabelle Michaud, Mélanie Henderson, Laurent Legault, Marie-Eve Mathieu
In children and adolescents, treatments for type 1 diabetes (T1D) have recently evolved with the introduction of the insulin pump. However, little is known about how a pump is associated with physical activity (PA) patterns. The goal of the study was to examine the activity profile of Canadian children and adolescents with T1D according to their insulin treatment (pump vs. injections), as well as barriers to exercise and parental lifestyle habits. A self-administered questionnaire was completed by 188 subjects with T1D aged 6 to 17 and their parents at the endocrinology clinic of Sainte-Justine's University Hospital Center (Montreal, Canada)...
December 8, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27983910/active-subjects-with-autoimmune-type-1-diabetes-have-better-metabolic-profiles-than-sedentary-controls
#10
M Adamo, R Codella, F Casiraghi, A Ferrulli, C Macrì, E Bazzigaluppi, I Terruzzi, L Inverardi, C Ricordi, L Luzi
<p>Previous studies in humans with type 1 diabetes (T1D) and in non-obese diabetic mice have investigated the beneficial immunomodulatory potential of aerobic physical activity. Performing high volume of aerobic exercise may favorably regulate autoimmunity in diabetes. We tested whether increased physical activity is a self-sufficient positive factor in T1D subjects.</p><p>During a 3-month observational period, active (6M; 40.5±6.1 years; BMI 24.5±2.1) and sedentary (4M, 3F; 35.9±8.9 years; BMI 25...
20, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27974167/lower-basal-insulin-dose-is-associated-with-better-control-in-type-1-diabetes
#11
David Strich, Lucy Balagour, Joelle Shenker, David Gillis
OBJECTIVE: To test the hypothesis that lower basal insulin doses may be paradoxically associated with better diabetic control, we assessed the association between the basal insulin dose and hemoglobin A1c (HbA1c) level in a group of children and young adults with type 1 diabetes. STUDY DESIGN: This was a retrospective study of 89 patients with type 1 diabetes (mean age, 14.67 ± 4.8 years; range, 3-29 years) treated in a single outpatient clinic. Forty-six of the 89 patients were treated with continuous subcutaneous insulin infusion, and the other 43 were treated with multiple daily injections (glargine as basal insulin)...
December 12, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27972334/health-economic-analysis-of-the-use-of-sensor-augmented-pump-with-predictive-suspend-function-sap-therapy-in-sweden-compared-to-insulin-pump-therapy-alone-csii-in-type-1-diabetic-patients
#12
S Roze, A Gherardi, S de Portu, J Jendle
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972182/cost-of-treatment-of-pancreas-transplantation-therapy-and-insulin-pump-therapy-of-type-i-diabetes-mellitus
#13
O Gajdoš, T Jedináková
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27959859/type-1-diabetes-prevention-a-goal-dependent-on-accepting-a-diagnosis-of-an-asymptomatic-disease
#14
Anette-G Ziegler, Ezio Bonifacio, Alvin C Powers, John A Todd, Leonard C Harrison, Mark A Atkinson
Type 1 diabetes, a disease defined by absolute insulin deficiency, is considered a chronic autoimmune disorder resulting from the destruction of insulin-producing pancreatic β-cells. The incidence of childhood-onset type 1 diabetes has been increasing at a rate of 3%-5% per year globally. Despite the introduction of an impressive array of therapies aimed at improving disease management, no means for a practical "cure" exist. This said, hope remains high that any of a number of emerging technologies (e.g., continuous glucose monitoring, insulin pumps, smart algorithms), alongside advances in stem cell biology, cell encapsulation methodologies, and immunotherapy, will eventually impact the lives of those with recently diagnosed or established type 1 diabetes...
November 2016: Diabetes
https://www.readbyqxmd.com/read/27959262/-lipoatrophy-after-insulin-injections-can-be-treated-with-lipofilling
#15
Pernille Strecker Lund, Helle Sjøstrand, Steen Henrik Matzen
Lipoatrophy is a known, albeit rare, side effect of insulin injections. We describe a case concerning a 17-year-old woman with insulin-dependent diabetes, who was treated with an insulin pump. In the areas surrounding the injection point subcutaneous lipoatrophy occurred. Such lipoatrophy is of cosmetic importance, and it may incur glycaemic imbalance due to altered and unpredictable absorption of insulin in the atrophied areas. With no spontaneous regeneration of the atrophied areas observed the patient was successfully treated with lipofilling in the atrophied areas...
December 5, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27955676/no-effect-of-yeast-like-fungi-on-lipid-metabolism-and-vascular-endothelial-growth-factor-level-in-children-and-adolescents-with-type-1-diabetes-mellitus
#16
Katarzyna Zorena, Beata Kowalewska, Małgorzata Szmigiero-Kawko, Piotr Wąż, Małgorzata Myśliwiec
BACKGROUND: The objective of the research was to investigate vascular endothelial growth factor (VEGF) levels in the context of lipid metabolism and amount of yeast-like fungi colonizing the digestive tract in children and adolescents with type 1 diabetes mellitus (T1DM). METHODS: The study included 45 children with T1DM and 27 age- and sex-matched healthy control subjects. In the study sample 33 T1DM patients were administered insulin pump therapy and 12 T1DM patients were administered multiple daily injections with insulin pen devices...
December 12, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27914157/-prevalence-of-dental-caries-in-type-1-diabetic-patients-treated-with-insulin-pump
#17
Rosana Garcia, Ana Coelho, Anabela Paula, Manuel Marques Ferreira, Francisco Caramelo, Luísa Barros, Carla Batista, Miguel Melo, Mário Jorge Silva, Eunice Carrilho
INTRODUCTION: Type 1 diabetes mellitus and oral health are strictly related on a reciprocal basis, and an increased susceptibility to a wide variety of oral diseases is recognised in these patients. The aim of the present study was to establish a relationship between the prevalence of dental caries in Type 1 diabetic patients treated with insulin pump and that of non-diabetic patients. MATERIAL AND METHODS: An observational clinical study of analytical and cross-sectional nature was conducted...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27899489/diabetes-device-use-in-adults-with-type-1-diabetes-barriers-to-uptake-and-potential-intervention-targets
#18
Molly L Tanenbaum, Sarah J Hanes, Kellee M Miller, Diana Naranjo, Rachel Bensen, Korey K Hood
OBJECTIVE: Diabetes devices (insulin pumps, continuous glucose monitors [CGMs]) are associated with benefits for glycemic control, yet uptake of these devices continues to be low. Some barriers to device uptake may be modifiable through psychosocial intervention, but little is known about which barriers and which patients to target. RESEARCH DESIGN AND METHODS: We surveyed 1,503 adult T1D Exchange participants (mean age 35.3 [SD 14.8] years, diagnosis duration 20...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27896954/effect-of-carbohydrate-counting-using-bolus-calculators-on-glycemic-control-in-type-1-diabetes-patients-during-continuous-subcutaneous-insulin-infusion
#19
Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire C Bastie, Yuko Tagaya, Aya Osaki, Yoko Shimoda, Ryo Shibusawa, Tsugumichi Saito, Atsushi Ozawa, Masanobu Yamada
This study examined the long-term efficacy of insulin pump therapy for type 1 diabetes patients when performed using carbohydrate counting with bolus calculators for one year. Twenty-two type 1 diabetes patients who had just started continuous subcutaneous insulin infusion were examined and divided into 2 groups: one that was educated about carbohydrate counting using bolus calculators (n=14) and another that did not use bolus calculators (n=8). After one year, the hemoglobin A1c levels of the patient group that used bolus calculators decreased persistently and significantly (P=0...
November 29, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27893687/spontaneous-and-transient-predinner-hyperglycemia-in-some-patients-with-diabetes-dusk-phenomenon
#20
Wei Li, Si-Na Du, Min-Jia Shi, Zhan-Zhan Sun
Blood glucose fluctuations have higher risk than absolute blood glucose level in diabetic chronic complications. At present, "dawn phenomenon" is well known by clinicians, but "dusk phenomenon" has not been recognized. This study explored the objective existence of "dusk phenomenon" (spontaneous and transient predinner hyperglycemia) and its clinical significance.The data of 54 patients with diabetes, who received routine insulin pump therapy between December 2010 and October 2012 in our hospital, were retrospectively analyzed...
November 2016: Medicine (Baltimore)
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