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https://www.readbyqxmd.com/read/29159870/predictive-hyperglycemia-and-hypoglycemia-minimization-in-home-double-blind-randomized-controlled-evaluation-in-children-and-young-adolescents
#1
Gregory P Forlenza, Dan Raghinaru, Faye Cameron, B Wayne Bequette, H Peter Chase, R Paul Wadwa, David M Maahs, Emily Jost, Trang T Ly, Darrell M Wilson, Lisa Norlander, Laya Ekhlaspour, Hyojin Min, Paula Clinton, Nelly Njeru, John W Lum, Craig Kollman, Roy W Beck, Bruce A Buckingham
OBJECTIVE: The primary objective of this trial was to evaluate the feasibility, safety, and efficacy of a predictive hyperglycemia and hypoglycemia minimization (PHHM) system vs predictive low glucose suspension (PLGS) alone in optimizing overnight glucose control in children 6 to 14 years old. RESEARCH DESIGN AND METHODS: Twenty-eight participants 6 to 14 years old with T1D duration ≥1 year with daily insulin therapy ≥12 months and on insulin pump therapy for ≥6 months were randomized per night into PHHM mode or PLGS-only mode for 42 nights...
November 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29157869/adapting-and-validating-a-measure-of-diabetes-specific-self-compassion
#2
M L Tanenbaum, R N Adams, J S Gonzalez, S J Hanes, K K Hood
AIMS: Self-compassion (SC), or treating oneself with kindness when dealing with personal challenges, has not been rigorously examined in people with T1D. SC has been shown to buffer against negative emotions and to be linked to improved health outcomes, but diabetes-specific SC has not been studied. This study aimed to adapt the Self-Compassion Scale and validate it for a diabetes-specific population. METHODS: We developed and validated a diabetes-specific version of the Self-Compassion Scale (Neff, 2003) in a sample of adults with T1D (N=542; 65% female; 97% non-Hispanic White; M age 41, SD=15...
October 26, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29157581/sleep-in-children-with-type-1-diabetes-and-their-parents-in-the-t1d-exchange
#3
Sarah S Jaser, Nicole C Foster, Bryce A Nelson, Julie M Kittelsrud, Linda A DiMeglio, Maryanne Quinn, Steven M Willi, Jill H Simmons
OBJECTIVES: Sleep has physiological and behavioral impacts on diabetes outcomes, yet little is known about the impact of sleep disturbances in children with type 1 diabetes. The current study sought to characterize sleep in children with type 1 diabetes and in their parents and to examine the associations between child sleep, glycemic control and adherence, parent sleep and well-being, parental fear of hypoglycemia, and nocturnal caregiving behavior. METHODS: Surveys were emailed to parents of 2- to 12-year-old participants in the Type 1 Diabetes (T1D) Exchange clinic registry...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29138541/the-effect-of-peer-support-in-adults-with-insulin-pump-treated-type-1-diabetes-a-pilot-study-of-a-flexible-and-participatory-intervention
#4
Lene Eide Joensen, Merete Meldgaard Andersen, Sabrina Jensen, Kirsten Nørgaard, Ingrid Willaing
Aim: The aim of this study was to explore the effects of a flexible and participatory peer support intervention in a clinical setting for adults with type 1 diabetes treated with an insulin pump, focusing on enhancing diabetes-specific social capital. The key questions were as follows: 1) what effects are appropriate to expect, according to participants? and 2) to what extent did these effects occur? Methods: Two peer support intervention programs were conducted in a diabetes specialist clinic (N=30)...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29120503/route-to-improving-type-1-diabetes-mellitus-glycaemic-outcomes-real-world-evidence-taken-from-the-national-diabetes-audit
#5
A H Heald, M Livingston, A Fryer, G Y C Moreno, N Malipatil, R Gadsby, W Ollier, M Lunt, M Stedman, R J Young
AIM: To use general practice-level data for England, available through the National Diabetes Audit, and primary care prescribing data to identify prescription treatment factors associated with variations in achieved glucose control (HbA1c ). METHODS: General practice-level National Diabetes Audit data on Type 1 diabetes, including details of population characteristics, services, proportion of people achieving target glycaemic control [HbA1c ≤58 mmol/mol (7.5%)] and proportion of people at high glycaemic risk [HbA1c >86 mmol/ml (10%)], were linked to 2013-2016 primary care diabetes prescribing data on insulin types and blood glucose monitoring for all people with diabetes...
November 9, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29118059/diabetes-care-disparities-in-long-standing-type-1-diabetes-in-canada-and-the-united-states-a-cross-sectional-comparison
#6
Alanna Weisman, Leif E Lovblom, Hillary A Keenan, Liane J Tinsley, Stephanie D'Eon, Genevieve Boulet, Mohammed A Farooqi, Julie A Lovshin, Andrej Orszag, Yuliya Lytvyn, Michael H Brent, Narinder Paul, Vera Bril, David Z Cherney, Bruce A Perkins
OBJECTIVE: To assess national differences in diabetes care and quality of life (QOL) between individuals with long-standing type 1 diabetes (≥50 years) in Canada and the U.S. RESEARCH DESIGN AND METHODS: Cross-sectional data from identical surveys administered in the Canadian Study of Longevity in Diabetes and the Joslin Medalist Study, collected in 2013-2016 and 2005-2011, respectively, were compared. Laboratory values and ophthalmic examination were completed by clinical care physicians for Canadians and the Joslin Clinic for Americans...
November 8, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29117449/route-to-improving-type-1-diabetes-mellitus-glycaemic-outcomes-real-world-evidence-taken-from-the-national-diabetes-audit
#7
P J Hammond
The National Diabetes Audit (NDA) has helped to highlight the disparity in glycaemic outcomes between those with Type 1 and those with Type 2 diabetes. Whilst ~70% of those with Type 2 diabetes achieve an HbA1c concentration <58 mmol/mol (7.5%), only 30% of those with Type 1 diabetes do so. Heald et al. [1] have used the data from the NDA to determine whether improved uptake of technology, particularly insulin pump therapy, might improve glycaemic outcomes. This article is protected by copyright. All rights reserved...
November 8, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29080577/a-primer-on-insulin-pump-therapy-for-health-care-providers
#8
REVIEW
Deborah L McCrea
An estimated 1 million people use an insulin pump to manage their diabetes. Few medical professionals understand or feel comfortable caring for people who use an insulin pump. This article will help the medical professional understand the reasons why the insulin pump helps the user to achieve better glycemic control, have more flexibility, and enjoy a better quality of life. Additionally, this article discusses the advantages, disadvantages, candidate selection, contraindications, basic functions, and troubleshooting of the insulin pump...
December 2017: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29073304/environmental-factors-affecting-management-of-type-1-diabetes-in-children-below-the-age-of-10
#9
Katarzyna Piechowiak, Beata Zduńczyk, Agnieszka Szypowska
INTRODUCTION: The way parents manage diabetes of their small children and environmental influence are crucial for maintaining glycemic control. The aim of the study was to assess environmental factors affecting metabolic control of young children with T1D treated with insulin pumps. MATERIAL AND METHODS: Parents of children with T1D under the age of 10 years completed: General Self-Efficacy Scale, Parental Diabetes Quality of Life Questionnaire, Beck Depression Inventory and a questionnaire on socioeconomic factors...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29068709/altered-patterns-of-early-metabolic-decompensation-in-type-1-diabetes-during-treatment-with-a-sglt2-inhibitor-an-insulin-pump-suspension-study
#10
Neha S Patel, Michelle A Van Name, Eda Cengiz, Lori R Carria, Stuart A Weinzimer, William V Tamborlane, Jennifer L Sherr
BACKGROUND: Enthusiasm for the benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as an adjunctive treatment in type 1 diabetes (T1D) has been offset by the possible increased risk of diabetic ketoacidosis (DKA). Since pump-treated T1D patients are susceptible to DKA due to infusion site problems, this study was undertaken to assess how treatment with SGLT2i affects patterns of early metabolic decompensation following suspension of basal insulin. METHODS: Ten T1D participants (age 19-35 years, duration 10 ± 8 years, A1c 7...
November 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29060152/personalization-of-a-compartmental-physiological-model-for-an-artificial-pancreas-through-integration-of-patient-s-state-estimation
#11
P Jallon, S Lachal, C Franco, G Charpentier, E Huneker, M Doron, Sylvia Franc, Pierre-Yves Benhamou, Sophie Borot, Bruno Guerci, He le Ne Hanaire, Nathalie Jeandidier, Alfred Penfornis, Eric Renard, Yves Reznik, Pauline Schaepelynck, Chantal Simon
Artificial Pancreas (AP) are developed for patients with Type 1 diabetes. This medical device system consists in the association of a subcutaneous continuous glucose monitor (CGM) providing a proxy of the patient's glycaemia and a control algorithm offering the real-time modification of the insulin delivery with an automatic command of the subcutaneous insulin pump. The most complex algorithms are based on a compartmental model of the glucoregulatory system of the patient coupled to an approach of MPC (Model-Predictive-Control) for the command...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055098/the-safety-of-the-batteries-and-power-units-used-in-insulin-pumps-a-pilot-cross-sectional-study-by-the-association-for-the-study-of-innovative-diabetes-treatment-in-japan
#12
Takashi Murata, Shinsuke Nirengi, Naoki Sakane, Akio Kuroda, Yushi Hirota, Munehide Matsuhisa, Mitsuyoshi Namba, Tetsuro Kobayashi
AIMS / INTRODUCTION: We investigated the safety of the batteries and power units used in insulin pumps in Japan. MATERIALS AND METHODS: A self-administered questionnaire was sent to the 201 members of the Association for Innovative Diabetes Treatment in Japan (ASINDTJ). RESULTS: Fifty-six members responded, and among the 1,499 active devices, 66 had episodes of trouble related to the batteries and power units. The ratio of reported troubles to the number of insulin pumps was significantly higher in insulin pumps with CGM sensor compared to insulin pumps without CGM sensor (Odds ratio 2...
October 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29054932/improving-paediatric-residents-knowledge-and-perspectives-regarding-the-insulin-pump-using-a-novel-educational-workshop
#13
Shipra Bansal, Albara Marwa, Kannan Kasturi, Sheila Perez-Colon
OBJECTIVES: As a pilot study, we aimed to investigate the knowledge and perceptions of categorical paediatric residents (RES) at our institution regarding insulin pumps (IPs) and the impact following a targeted workshop. METHODS: All RES at our institution in attendance at a routine noon conference participated in a workshop, completing an anonymous survey before and right after the intervention to evaluate knowledge, attitudes and self-reported comfort regarding IPs...
October 20, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29049584/association-of-insulin-pump-therapy-vs-insulin-injection-therapy-with-severe-hypoglycemia-ketoacidosis-and-glycemic-control-among-children-adolescents-and-young-adults-with-type-1-diabetes
#14
COMPARATIVE STUDY
Beate Karges, Anke Schwandt, Bettina Heidtmann, Olga Kordonouri, Elisabeth Binder, Ulrike Schierloh, Claudia Boettcher, Thomas Kapellen, Joachim Rosenbauer, Reinhard W Holl
Importance: Insulin pump therapy may improve metabolic control in young patients with type 1 diabetes, but the association with short-term diabetes complications is unclear. Objective: To determine whether rates of severe hypoglycemia and diabetic ketoacidosis are lower with insulin pump therapy compared with insulin injection therapy in children, adolescents, and young adults with type 1 diabetes. Design, Setting, and Participants: Population-based cohort study conducted between January 2011 and December 2015 in 446 diabetes centers participating in the Diabetes Prospective Follow-up Initiative in Germany, Austria, and Luxembourg...
October 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29026740/diabetes-and-ramadan-a-concise-and-practical-update
#15
REVIEW
Mohamed H Ahmed, Nazik Elmalaika Husain, Wadie M Elmadhoun, Sufian K Noor, Abbas A Khalil, Ahmed O Almobarak
Despite the fact that the month of Ramadan includes 29-30 days and the duration of fasting for each day can last for between 12 and 16 h, it was estimated that a large number of individuals with diabetes do fast during Ramadan. In light of recent advancement of new pharmacological agents, drugs such as vildagliptin, sitagliptin, and liraglutide were found to be safe to use during this month of fasting. These therapeutic agents can also be used in combination with metformin. The use of sulfonylureas, in most of the recent guidelines about diabetes and Ramadan, seems not to gain much support due to the risk of hypoglycemia...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29025203/impact-of-targeted-education-on-managing-warning-and-error-signals-by-children-and-adolescents-with-type-1-diabetes-using-the-accu-chek-combo-insulin-pump-system
#16
Asma Deeb, Nabras Al Qahtani, Amal Al Ali, Mariette Akle
PURPOSE: Insulin pumps are widely used in diabetes. They are equipped with safety alarms to alert users. Pump manuals contain alarm codes and how to troubleshoot them. However, these manuals are lengthy and difficult to use, particularly in emergencies. We aim to assess the impact of targeted education on warnings and errors in improving competency to troubleshoot the alarms. METHODS: Twenty-one patients, with a median age of 13, were recruited over a 5-month period...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29021198/insulin-pumps-are-linked-to-lower-risk-of-complications-in-young-people
#17
Jacqui Wise
No abstract text is available yet for this article.
October 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28990436/acceptability-of-implantable-continuous-glucose-monitoring-sensor
#18
Katharine D Barnard, Jort Kropff, Pratik Choudhary, Sankalpa Neupane, Stephen C Bain, Christoph Kapitza, Thomas Forst, Manuela Link, Colleen Mdingi, J Hans DeVries
BACKGROUND: Real-time continuous glucose monitoring is associated with significant benefits for diabetes management. Implantable sensors could overcome some challenges reportedly associated with device visibility, psychosocial functioning and sensor durability. METHODS: A psychosocial assessment was conducted to determine acceptability and impact of an implantable continuous glucose monitoring (CGM) sensor as part of the PRECISE trial. Questionnaires were administered to participants comprising the Diabetes Distress Scale, the CGM impact scale, and bespoke device satisfaction...
October 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28989086/reported-gastroparesis-in-adults-with-type-1-diabetes-t1d-from-the-t1d-exchange-clinic-registry
#19
Grazia Aleppo, Peter Calhoun, Nicole C Foster, David M Maahs, Viral N Shah, Kellee M Miller
OBJECTIVE: To better understand the prevalence and impact of gastroparesis in the T1D Exchange clinic registry database. METHODS: The analysis included 7107 adult participants with T1D across 45 sites (median age 46years. and median duration 24years). Linear and logistic regression models were used to assess the association of gastroparesis vs. no gastroparesis (obtained from medical record) with demographic characteristics, glycemic control and diabetes complications...
September 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28981324/detailed-analysis-of-insulin-absorption-variability-and-the-tissue-response-to-continuous-subcutaneous-insulin-infusion-catheter-implantation-in-swine
#20
Jasmin R Hauzenberger, Brian R Hipszer, Channy Loeum, Peter A McCue, Mark DeStefano, Marc C Torjman, Mahmut T Kaner, Alek R Dinesen, Inna Chervoneva, Thomas R Pieber, Jeffrey I Joseph
BACKGROUND: Worldwide, ∼1 million people manage their type 1 diabetes with an insulin pump and a continuous subcutaneous insulin infusion (CSII) catheter. Patients routinely insert a new catheter every 2-3 days due to increasing variability of insulin absorption over time. Catheter insertion and maintenance damage capillaries, lymphatics, cells, and connective tissue leading to an acute inflammatory response. METHODS: We compared an investigational CSII catheter (IC) and a commercial CSII catheter (CC) regarding insulin absorption pharmacokinetics (PK) and tissue inflammation...
November 2017: Diabetes Technology & Therapeutics
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