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https://www.readbyqxmd.com/read/28110470/thermal-control-weather-and-aging
#1
REVIEW
Alexandra Schneider, Regina Rückerl, Susanne Breitner, Kathrin Wolf, Annette Peters
PURPOSE OF THE REVIEW: The purpose of this review is to highlight the latest developments in the field of weather and health with a focus on the elderly. The current state of knowledge is summarized and open questions and emerging fields of research are discussed. RECENT FINDINGS: It is expected that climate change will lead to higher global average surface temperatures and more extreme climatic conditions. Previous studies have shown that non-optimal temperatures are associated with increased morbidity and mortality, specifically in elderly people...
January 21, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28109973/sleep-loss-and-structural-plasticity
#2
REVIEW
Cassandra C Areal, Simon C Warby, Valérie Mongrain
Wakefulness and sleep are dynamic states during which brain functioning is modified and shaped. Sleep loss is detrimental to many brain functions and results in structural changes localized at synapses in the nervous system. In this review, we present and discuss some of the latest observations of structural changes following sleep loss in some vertebrates and insects. We also emphasize that these changes are region-specific and cell type-specific and that, most importantly, these structural modifications have functional roles in sleep regulation and brain functions...
January 18, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28109644/fluid-extravasation-in-hip-arthroscopy-a-systematic-review
#3
REVIEW
Seper Ekhtiari, Chloe E Haldane, Darren de Sa, Nicole Simunovic, Olufemi R Ayeni
PURPOSE: The purpose of this systematic review was to (1) characterize cases of fluid extravasation during hip arthroscopy and explore common factors among them and (2) describe management strategies and outcomes of this complication. METHODS: The databases MEDLINE, EMBASE, and PubMed were searched and screened in duplicate. Data regarding patient demographics, fluid management, presentation, management, and outcomes were collected. Study quality was assessed in duplicate using the Methodological Index for Non-Randomized Studies Criteria...
January 18, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28109621/-the-latest-in-paediatric-resuscitation-recommendations
#4
Jesús López-Herce, Antonio Rodríguez, Angel Carrillo, Nieves de Lucas, Custodio Calvo, Eva Civantos, Eva Suárez, Sara Pons, Ignacio Manrique
Cardiac arrest has a high mortality in children. To improve the performance of cardiopulmonary resuscitation, it is essential to disseminate the international recommendations and the training of health professionals and the general population in resuscitation. This article summarises the 2015 European Paediatric Cardiopulmonary Resuscitation recommendations, which are based on a review of the advances in cardiopulmonary resuscitation and consensus in the science and treatment by the International Council on Resuscitation...
January 18, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28109401/melanoma-last-call-for-radiotherapy
#5
REVIEW
Sophie Espenel, Alexis Vallard, Chloé Rancoule, Max-Adrien Garcia, Jean-Baptiste Guy, Cyrus Chargari, Eric Deutsch, Nicolas Magné
Melanoma is traditionally considered to be a radioresistant tumor. However, radiotherapy and immunotherapy latest developments might upset this radiobiological dogma. Stereotactic radiotherapy allows high dose per fraction delivery, with high dose rate. More DNA lethal damages, less sublethal damages reparation, endothelial cell apoptosis, and finally clonogenic cell dysfunction are produced, resulting in improved local control. Radiotherapy can also enhance immune responses, inducing neoantigens formation, tumor antigen presentation, and cytokines release...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28108747/national-guidelines-for-smoking-cessation-in-primary-care-a-literature-review-and-evidence-analysis
#6
Marjolein Verbiest, Evelyn Brakema, Rianne van der Kleij, Kate Sheals, Georgia Allistone, Siân Williams, Andy McEwen, Niels Chavannes
: National guidelines for smoking cessation in primary care can be effective in improving clinical practice. This study assessed which parties are involved in the development of such guidelines worldwide, which national guidelines address primary care, what recommendations are made for primary care settings, and how these recommendations correlate with each other and with current evidence. We identified national guidelines using an online resource. Only the most recent version of a guideline was included...
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28107859/dengue-fever-may-mislead-the-surgeons-when-it-presents-as-an-acute-abdomen
#7
Bingumal Jayasundara, Lalith Perera, Ajith de Silva
OBJECTIVE: To review the management experience of a consecutive series of patients presenting as acute surgical abdomen whom were ultimately diagnosed to have DF (Dengue fever)/DHF (Dengue hemorrhagic fever). METHODS: Clinical data of all cases of apparent acute abdomen (AA) which were later confirmed as having DF/DHF reviewed by two surgical units from December 2012 to December 2013 were analyzed. Initially confirmed patients with DF/DHF who developed abdominal symptoms were not considered...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107209/nephropathic-cystinosis-an-update
#8
Koenraad R Veys, Mohamed A Elmonem, Fanny O Arcolino, Lambertus van den Heuvel, Elena Levtchenko
PURPOSE OF REVIEW: Over the past few decades, cystinosis, a rare lysosomal storage disorder, has evolved into a treatable metabolic disease. The increasing understanding of its pathophysiology has made cystinosis a prototype disease, delivering new insights into several fundamental biochemical and cellular processes. RECENT FINDINGS: In this review, we aim to provide an overview of the latest advances in the pathogenetic, clinical, and therapeutic aspects of cystinosis...
January 18, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28106685/totally-implantable-venous-access-devices-a-review-of-complications-and-management-strategies
#9
Omidreza Tabatabaie, Gyulnara G Kasumova, Mariam F Eskander, Jonathan F Critchlow, Nicholas E Tawa, Jennifer F Tseng
OBJECTIVE: Totally implantable venous access devices (portacaths, or "ports"), are widely used for intermittent central venous access especially for cancer patients. Although ports have a superior safety margin compared with other long-term venous access devices, there are a number of complications associated with their use. METHODS: This is a narrative review. We searched PubMed and Google Scholar for articles about complications related to the use of portacaths...
February 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28105196/nanotechnology-for-multimodality-treatment-of-cancer
#10
Xiao-Ying Zhang, Pei-Ying Zhang
Nanotechnology is the latest evolving field and its applications in medicine in recent decades has shown great potential. It has also given a new face to the therapeutics against cancer in recent years. The electronic databases of MEDLINE, EMBASE and PubMed were searched for recent studies, reporting the importance of nanomedicine. The concluding remarks of the above papers mostly confirmed the growing potential of nanomedicine, particularly in the field of cancer. Furthermore, nanomedicine has been observed to promote the therapeutic effect of agents by formulating them into nanocarriers...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104991/prevalence-of-hepatitis-c-virus-infection-among-hemodialysis-patients-in-the-middle-east-a-systematic-review-and-meta-analysis
#11
Soheil Ashkani-Esfahani, Seyed Moayed Alavian, Mohammad Salehi-Marzijarani
AIM: To determine hepatitis C virus (HCV) infection prevalence in each country of the Middle-East and the overall prevalence of the region. METHODS: In this systematic review, we gathered all documents related to HCV infection prevalence among hemodialysis patients in 17 middle-east countries from April 2006 to March 2016. We selected only cross-sectional studies that had proper sampling and measurement methods as well as a valid statistical analysis. RESULTS: After screening of 7311 documents, 56 studies were selected reporting the prevalence of HCV infection among hemodialysis patients from 10 countries of the region...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28104515/biomass-density-function-relationships-in-suspended-growth-biological-processes-a-critical-review
#12
REVIEW
Lin Li, Krishna R Pagilla
Good settling performance in suspended growth biomass systems, for example in activated sludge (AS) process, leads to efficient wastewater and sludge treatment. Factors that cause the differences in settleablility of AS include the morphology of bacteria, microbial community structure, and the density of bacteria and flocs. Density of AS at three levels, namely, cell, floc, and process, have been discussed here to explain the variations in AS settleability. Dense materials, inside or outside the cell, significantly increase density of AS bacteria or flocs...
January 9, 2017: Water Research
https://www.readbyqxmd.com/read/28104501/esotropia-with-an-accommodative-component-after-surgery-for-infantile-esotropia-compared-to-primary-accommodative-esotropia
#13
Kyung-Ah Park, Sei Yeul Oh
PURPOSE: To compare the clinical outcomes of patients with an esotropia with an accommodative component after infantile esotropia surgery and patients with primary refractive accommodative esotropia. METHODS: The medical records of patients with postoperative (secondary group) and primary refractive accommodative esotropia (primary group) were reviewed retrospectively. Changes in ocular alignment, refractive error, weaning rate, decompensation rate over time, and sensory outcomes were compared...
January 16, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28104294/rodent-models-of-depression-cardiovascular-comorbidity-bridging-the-known-to-the-new
#14
REVIEW
Luca Carnevali, Nicola Montano, Rosario Statello, Andrea Sgoifo
Numerous epidemiological studies have demonstrated a close and bidirectional association between depression and cardiovascular disorders (CVD). This comorbidity places a significant burden on individuals and the healthcare system. Not surprisingly, in the last two decades preclinical research in the field of depression and CVD has rapidly progressed. Multiple studies have demonstrated that aspects of human depression/cardiovascular comorbidity can be modeled in rodents exposed to chronic stress paradigms and that a depressive-like syndrome can be induced in rodent models of CVD...
January 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28104276/optogenetic-toolkit-for-precise-control-of-calcium-signaling
#15
REVIEW
Guolin Ma, Shufan Wen, Lian He, Yun Huang, Youjun Wang, Yubin Zhou
Calcium acts as a second messenger to regulate a myriad of cell functions, ranging from short-term muscle contraction and cell motility to long-term changes in gene expression and metabolism. To study the impact of Ca(2+)-modulated 'ON' and 'OFF' reactions in mammalian cells, pharmacological tools and 'caged' compounds are commonly used under various experimental conditions. The use of these reagents for precise control of Ca(2+) signals, nonetheless, is impeded by lack of reversibility and specificity. The recently developed optogenetic tools, particularly those built upon engineered Ca(2+) release-activated Ca(2+) (CRAC) channels, provide exciting opportunities to remotely and non-invasively modulate Ca(2+) signaling due to their superior spatiotemporal resolution and rapid reversibility...
January 16, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28103975/-research-progress-of-targeted-therapy-for-egfr-gene-in-non-small-cell-lung-cancer
#16
Hui Zhang, Shucai Zhang
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have brought great clinical benefit to patients with EGFR-sensitive mutations. With the deepening of clinical and basic research, EGFR-TKIs have received more and more attention. In this review, we summarize the latest research development about EGFR-targeted drugs in 2016.
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28103165/burn-wound-healing-present-concepts-treatment-strategies-and-future-directions
#17
A Oryan, E Alemzadeh, A Moshiri
Burns are the most extensive forms of soft tissue injuries occasionally resulting in extensive and deep wounds and death. Burns can lead to severe mental and emotional distress, because of excessive scarring and skin contractures. Treatment of burns has always been a difficult medical problem and many different methods have been used to treat such injuries, locally. Biofilms are a collection of microorganisms that delay wound healing. One of the new methods of prevention and treatment of burn wound infections is application of antimicrobials, which act on biofilms and prevent the wound infection...
January 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28101938/the-second-team-haemophilia-education-meeting-2016-frankfurt-germany
#18
Erik Berntorp, Yesim Dargaud, Daniel Hart, Sébastien Lobet, Maria Elisa Mancuso, Roseline d'Oiron, David Perry, Debra Pollard, Marijke van den Berg, Jan Blatný, Hervé Chambost, Andrea S Doria, Pål André Holme, Radoslaw Kaczmarek, Lorenzo Mantovani, Paul McLaughlin, Lochana Nanayakkara, Pia Petrini, Thomas Sannié, Edward Laane, Raquel Maia, Athina Dettoraki, Anna Farrell, Susan Halimeh, Sayma Raza, Stephanie Taylor
The first Team Haemophilia Education (THE) Meeting was held on 7-8 May 2015 in Amsterdam, The Netherlands. It aimed to promote the optimal care of patients with haemophilia through education of the multidisciplinary treatment team. This was achieved by reviewing the latest developments in haemophilia management, considering how these can be implemented in the clinic to improve patient care and providing a platform for networking and debate for all haemophilia treatment team members. The second THE Meeting was held on 19-20 May in Frankfurt, Germany, and participants included doctors, nurses, physiotherapists, patient representatives and data management staff from 20 different countries...
January 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28101766/crossing-the-blood-brain-barrier-recent-advances-in-drug-delivery-to-the-brain
#19
Mayur M Patel, Bhoomika M Patel
CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood-brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. This is a pronounced challenge for the pharmaceutical fraternity. Hence, in addition to the discovery of novel entities and drug candidates, scientists are also developing new formulations of existing drugs for brain targeting...
January 18, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28101624/the-safety-and-efficacy-of-cardiac-contractility-modulation-in-heart-failure-a%C3%A2-meta-analysis-of-clinical-trials
#20
X Liu, H J Yang, H Q Ping, S Qiu, S Shi, B Yang
BACKGROUND: Cardiac contractility modulation (CCM) has developed as a promising treatment device for heart failure (HF). This meta-analysis aimed at systematically reviewing the latest available published trials to provide evidence on the safety and efficacy of CCM in patients with HF. METHODS: We searched the Cochrane Central Resister of Controlled Trials, PubMed, and EMBASE in May 2016 to identify eligible clinical trials comparing CCM with sham treatment or with usual care...
January 18, 2017: Herz
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