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Fgf21 and fructose

Zhe Huang, Aimin Xu, Bernard M Y Cheung
Fibroblast growth factor (FGF) 21 belongs to the FGF superfamily that is involved in cell proliferation and differentiation, neural development, angiogenesis, and metabolism. FGF21 requires β-Klotho as a co-receptor. Tissues involved in metabolism such as the liver, adipose tissues, skeletal muscle, and pancreas express FGF21. Starvation increases hepatic expression of FGF21, which then acts centrally to increase hepatic gluconeogenesis. FGF21 also increases fatty acid oxidation. This may be relevant in cold exposure, when expression of FGF21 is induced...
April 2017: Current Hypertension Reports
Ffolliott M Fisher, MiSung Kim, Ludivine Doridot, Jeremy C Cunniff, Thomas S Parker, Daniel M Levine, Marc K Hellerstein, Lisa C Hudgins, Eleftheria Maratos-Flier, Mark A Herman
OBJECTIVE: Increased fructose consumption is a contributor to the burgeoning epidemic of non-alcoholic fatty liver disease (NAFLD). Recent evidence indicates that the metabolic hormone FGF21 is regulated by fructose consumption in humans and rodents and may play a functional role in this nutritional context. Here, we sought to define the mechanism by which fructose ingestion regulates FGF21 and determine whether FGF21 contributes to an adaptive metabolic response to fructose consumption...
January 2017: Molecular Metabolism
Jian-Li He, Miao Zhao, Jing-Jun Xia, Jian Guan, Yang Liu, Lu-Qi Wang, Dong-Xue Song, Mei-Yu Qu, Meng Zuo, Xin Wen, Xue Yu, Rong Huo, Zhen-Wei Pan, Tao Ban, Yan Zhang, Jiu-Xin Zhu, Weinian Shou, Guo-Fen Qiao, Bai-Yan Li
Fibroblast growth factor-21 (FGF21) is closely related to various metabolic and cardiovascular disorders. However, the direct targets and mechanisms linking FGF21 to blood pressure control and hypertension are still elusive. Here we demonstrated a novel regulatory function of FGF21 in the baroreflex afferent pathway (the nucleus tractus solitarii, NTS; nodose ganglion, NG). As the critical co-receptor of FGF21, β-klotho (klb) significantly expressed on the NTS and NG. Furthermore, we evaluated the beneficial effects of chronic intraperitoneal infusion of recombinant human FGF21 (rhFGF21) on the dysregulated systolic blood pressure, cardiac parameters, baroreflex sensitivity (BRS) and hyperinsulinemia in the high fructose-drinking (HFD) rats...
July 8, 2016: Scientific Reports
Jody R Dushay, Elena Toschi, Emilie K Mitten, Ffolliott M Fisher, Mark A Herman, Eleftheria Maratos-Flier
OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a hormone with pleiotropic metabolic activities which, in rodents, is robustly regulated by fasting and ketogenic diets. In contrast, similar dietary interventions have either no or minimal effects on circulating FGF21 in humans. Moreover, no intervention or dietary challenge has been shown to acutely stimulate circulating FGF21 in either humans or animals. Recent animal data suggest that the transcription factor Carbohydrate Responsive-Element Binding Protein (ChREBP) stimulates hepatic FGF21 expression and that fructose may activate hepatic ChREBP more robustly than glucose...
January 2015: Molecular Metabolism
Susanna M Hofmann, Peter J Havel
No abstract text is available yet for this article.
January 2015: Molecular Metabolism
Sheng-long Zhu, Gui-ping Ren, Zhen-yu Zhang, Wen-fei Wang, Xian-long Ye, Miao-miao Han, Jing-zhuang Zhao, Tong-yu Xu, Ming-yao Liu, De-shan Li
This study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on hypertension induced by insulin resistance in rats and to provide mechanistic insights into its therapeutic effect. Male Sprague-Dawley (SD) rats were fed with high-fructose (10%) water to develop mild hypertensive models within 4 weeks, then randomized into 4 groups: model control, FGF21 0.25, 0.1 and 0.05 micromol x kg(-1) x d(-1) groups. Five age-matched normal SD rats administrated with saline were used as normal controls...
September 2013: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
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