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Nima Rezaei

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https://www.readbyqxmd.com/read/28036156/interleukin-4-cytokine-single-nucleotide-polymorphisms-in-kawasaki-disease-a-case-control-study-and-a-review-of-knowledge
#1
Raheleh Assari, Yahya Aghighi, Vahid Ziaee, Maryam Sadr, Arezou Rezaei, Farzaneh Rahmani, Zeinab Sadr, Seyed Reza Raeeskarami, Mohammad Hassan Moradinejad, Nima Rezaei
AIM: Kawasaki disease (KD) is a systemic vasculitis of medium-sized arteries. High levels of interleukin 4 (IL-4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL-4 and IL-4R gene polymorphisms were investigated in Iranian children with KD. METHODS: Fifty-five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL-4 gene at positions -1098 (rs2243248), -590 (rs2243250) and -33 (rs2070874), as well as IL-4RA gene at position +1902 (rs180275) were assessed in patients and the control group...
December 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28013299/autoimmunity-in-primary-antibody-deficiencies
#2
Gholamreza Azizi, Moslem Ahmadi, Hassan Abolhassani, Reza Yazdani, Hamed Mohammadi, Abbas Mirshafiey, Nima Rezaei, Asghar Aghamohammadi
Primary antibody deficiencies (PADs) are the most common inherited primary immunodeficiencies in humans, characterized by hypogammaglobulinemia, an inability to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimmunity are associated with the various types of PAD. Both systemic and organ-specific autoimmune diseases could be attributed to B-cell defects in PAD patients...
December 24, 2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28011864/combined-immunodeficiency-and-epstein-barr-virus-induced-b-cell-malignancy-in-humans-with-inherited-cd70-deficiency
#3
Hassan Abolhassani, Emily S J Edwards, Aydan Ikinciogullari, Huie Jing, Stephan Borte, Marcus Buggert, Likun Du, Mami Matsuda-Lennikov, Rosa Romano, Rozina Caridha, Sangeeta Bade, Yu Zhang, Juliet Frederiksen, Mingyan Fang, Sevgi Kostel Bal, Sule Haskologlu, Figen Dogu, Nurdan Tacyildiz, Helen F Matthews, Joshua J McElwee, Emma Gostick, David A Price, Umaimainthan Palendira, Asghar Aghamohammadi, Bertrand Boisson, Nima Rezaei, Annika C Karlsson, Michael J Lenardo, Jean-Laurent Casanova, Lennart Hammarström, Stuart G Tangye, Helen C Su, Qiang Pan-Hammarström
In this study, we describe four patients from two unrelated families of different ethnicities with a primary immunodeficiency, predominantly manifesting as susceptibility to Epstein-Barr virus (EBV)-related diseases. Three patients presented with EBV-associated Hodgkin's lymphoma and hypogammaglobulinemia; one also had severe varicella infection. The fourth had viral encephalitis during infancy. Homozygous frameshift or in-frame deletions in CD70 in these patients abolished either CD70 surface expression or binding to its cognate receptor CD27...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27931829/primary-immunodeficiencies-associated-with-ebv-induced-lymphoproliferative-disorders
#4
REVIEW
Mahsima Shabani, Kim E Nichols, Nima Rezaei
Primary immunodeficiency diseases (PIDs) are a subgroup of inherited immunological disorders that increase susceptibility to viral infections. Among the range of viral pathogens involved, EBV remains a major threat because of its high prevalence of infection among the adult population and its tendency to progress to life-threatening lymphoproliferative disorders (LPDs) and/or malignancy. The high mortality in immunodeficient patients with EBV-driven LPDs, despite institution of diverse and often intensive treatments, prompts the need to better study these PIDs to identify and understand the affected molecular pathways that increase susceptibility to EBV infection and progression...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27921409/hla-drb-and-hla-dqb-allele-and-haplotype-frequencies-in-iranian-patients-with-recurrent-aphthous-stomatitis
#5
Shamsolmoulouk Najafi, Mahsa Mohammadzadeh, Alireza Zare Bidoki, Ghasem Meighani, Saeed Aslani, Mahdi Mahmoudi, Nima Rezaei
Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 unrelated healthy subjects as control group were investigated...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27920889/lack-of-association-between-interleukin-12-gene-polymorphisms-and-recurrent-aphthous-stomatitis
#6
Isaac Firouze Moqadam, Shamsolmoulouk Najafi, Mahsa Mohammadzadeh, Alireza Zare Bidoki, Hila Yousefi, Elham Farhadi, Arghavan Tonekaboni, Ghasem Meighani, Mohsen Mohammadzadeh, Ali Akbar Amirzargar, Nima Rezaei
No abstract text is available yet for this article.
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27917623/impact-of-ige-mediated-food-allergy-on-parental-quality-of-life-in-iranian-patients
#7
Seyed Mohammad Fathi, Marzieh Tavakol, Nima Rezaei, Masoud Movahedi, Asghar Aghamohammadi, Mansoureh Shariat, Bamdad Sadeghi, Nasrin Behniafard, Behzad Darabi, Alireza Hajikhani, Ibrahim Abdollahpour, Mohammad Gharagozlou
Food allergy is a common disorder especially in the first years of life. Strict avoidance of the responsible food is the most effective therapeutic measure so far. But this continuous vigilance could be stressful for the patient and family and decreases their quality of life (QOL). This survey was designed to evaluate the impact of IgE-mediated food allergy on parental QOL in Iranian patients and to develop a valid Persian version of "Food Allergy Quality Of Life- Parental Burden (FAQL-PB) questionnaire". 90 patients (28 females, 62 males) and their parents who were referred to the clinic of Allergy in Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran were enrolled...
October 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27893166/the-association-between-parental-consanguinity-and-primary-immunodeficiency-diseases-a-systematic-review-and-meta-analysis
#8
Hasti Hadizadeh, M Masoud Salehi, Shabnam Khoramnejad, Kia Vosoughi, Nima Rezaei
BACKGROUND: We aimed to establish the prevalence of parental consanguinity among patients with primary immunodeficiency diseases (PID), and compare the prevalence with the general population. METHOD: We searched PubMed, EMBASE, and Scopus for studies mentioning parental consanguinity prevalence in PID patients and calculated the prevalence odds ratio (POR) of parental consanguinity in each study, compared to a matched healthy population. RESULTS: We identified 21 eligible studies with a total population of 18091 accounting for sample overlap...
November 28, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27888588/lps-responsive-beige-like-anchor-gene-mutation-associated-with-possible-bronchiolitis-obliterans-organizing-pneumonia-associated-with-hypogammaglobulinemia-and-normal-igm-phenotype-and-low-number-of-b-cells
#9
Sima Shokri, Mohammad Nabavi, Tatjana Hirschmugl, Asghar Aghamohammadi, Saba Arshi, Mohamad Hassan Bemanian, Morteza Fallahpour, Rasool Molatefi, Mahsa Rekabi, Narges Eslami, Javad Ahmadian, Kian Darabi, Gholam Reza Sedighi, Maryam Monajemzadeh, Mohammadreza Modaresi, Nima Parvaneh, Kaan Boztug, Nima Rezaei
LPS-Responsive Beige-like Anchor (LRBA) deficiency is a disease which has recently been described in a group of patients with common variable immunodeficiency (CVID) in association with autoimmunity and/or inflammatory bowel disease (IBD)-like phenotype. We here describe a 10-year-old boy who experienced recurrent infections, mainly in the respiratory system, associated with thrombocytopenia and anemia. Immunological workup showed low numbers of B cells and low IgG, but normal IgM levels. In spite of therapeutic doses of antibiotics, antivirals, and antifungal agents, in addition to immunoglobulin replacement therapy, he developed disseminated involvement of both lungs with peripheral nodules; transbronchial lung biopsy revealed possible bronchiolitis obliterans organizing pneumonia (BOOP)...
October 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27878683/april-gene-polymorphism-and-serum-sapril-levels-in-children-with-systemic-lupus-erythematosus
#10
Shideh Namazi, Nader Tajik, Vahid Ziaee, Maryam Sadr, Samaneh Soltani, Arezou Rezaei, Samaneh Zoghi, Nima Rezaei
Systemic lupus erythematosus (SLE) is a multi-factor autoimmune disorder with diverse clinical manifestations and unclear pathogenesis. Genetic components play important roles in the incidence and development of SLE. Among these, APRIL as a cytokine has roles in the stimulation and antibody production in B cells. APRIL was hypothesized to be associated with SLE. The aim of this study was to assess the involvement of the APRIL gene in SLE susceptibility in Iranian patients. A single-nucleotide polymorphism (SNP) for rs11552708 of APRIL gene was analyzed by real-time PCR in 60 SLE Iranian children and 64 healthy controls...
November 23, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27832689/comparison-of-oral-midazolam-with-intravenous-midazolam-for-sedation-children-during-upper-gastrointestinal-endoscopy
#11
Ahmad Khodadad, Majid Aflatoonian, Rozita Jalilian, Nazanin Babaei, Farzaneh Motamed, Alireza Ebrahime Soltani, Behnaz Rasoolzadeh, Fatemeh Motavasselian, Nima Rezaei
Upper endoscopy is a common procedure for the diagnosis and treatment of upper digestive tract diseases. The increasing number of pediatric gastrointestinal procedures has led to increasing attention on the safety and efficacy of medications used for sedation during the procedure. This randomized blinded interventional study was designed to compare the effect of oral midazolam with intravenous (IV) midazolam as a sedative medication in 119 children undergoing endoscopy. The mean time to sedation was 2.2±0...
September 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27823646/radioimmunotherapy-in-non-hodgkin-lymphoma-prediction-and-assessment-of-response
#12
REVIEW
Mahsa Eskian, MirHojjat Khorasanizadeh, Francoise Kraeber-Bodere, Nima Rezaei
Non-Hodgkin lymphoma (NHL) is one of the most common malignancies and a major cause of morbidity and mortality. Radioimmunotherapy (RIT) is a novel modality for treating NHL which offers the combined use of monoclonal antibodies for specific targeting of malignant cells and radiation for killing these cells. Despite the promising results favoring RIT in several clinical studies in different target populations and NHL types, Food and Drug Administration (FDA) approval for RIT agents is restricted to a limited number of indications and agents, maybe because of several ambiguities that still exist in the field...
November 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27780734/proteins-brighten-the-brain
#13
REVIEW
Ameneh Zare-Shahabadi, Akram Ataei, Nima Rezaei
Through selective activation/inhibition or dissection of neuronal circuits, optogenetic tools have raised hopes for a better understanding of neuropsychiatric mechanisms and therapeutic targets for various disorders. Although, overcoming serious limitations result in from conventional neuronal circuit study, this method has its own imperfections, such as optogenetic modulation of neural activity, using an internal, animal-generated, light source. In this review, limitations of external light delivery systems and possible approaches for using internal light sources in laboratory animals and perhaps, human being, are being addressed...
December 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27752182/introducing-a-new-experimental-islet-transplantation-model-using-biomimetic-hydrogel-and-a-simple-high-yield-islet-isolation-technique
#14
Jamal Mohammadi Ayenehdeh, Bahareh Niknam, Seyed Mahmoud Hashemi, Hossein Rahavi, Nima Rezaei, Masoud Soleimani, Nader Tajik
BACKGROUND: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functional islets and transplantation are crucial. METHODS: The present study has introduced an experimental model that overcomes some critical issues in islet transplantation, including in situ pancreas perfusion by digestive enzymes through common bile duct...
October 18, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27732119/association-of-ptpn22-gene-polymorphisms-with-susceptibility-to-juvenile-idiopathic-arthritis-in-iranian-population
#15
Tayyeb Bahrami, Samaneh Soltani, Kasra Moazzami, Mir Saeed Yekaninejad, Arash Salmaninejad, Ehsan Soltaninejad, Vahid Ziaee, Nima Rezaei
Juvenile idiopathic arthritis (JIA), the most common cause of chronic arthritis in children, is a complex immune-mediated disease with considerable long-term morbidity and mortality. According to previous studies, PTPN22 gene has been associated with JIA in several populations. In the present study, we attempted to determine the association of PTPN22 single nucleotide polymorphisms (SNPs) with susceptibility to JIA in Iranian population. Using the Real-time PCR allelic discrimination method, samples consisting of 55 unrelated patients and 93 healthy controls were genotyped...
October 12, 2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27701726/effect-of-air-pollution-in-frequency-of-hospitalizations-in-asthmatic-children
#16
Medhi Alizadeh, Leila Ghasemi Hashtroodi, Zahra Chavoshzadeh, Nima Rezaei
Asthma is one of the most common diseases in childhood, which has been increased during last decade because of epidemiological pattern changes with climate and industrialization of the communities. There are some controversies on the relationship between air pollution and asthma. Tehran, as the capital of Iran, is one of the densest populations and is one of the most polluted cities in the world. This study was performed to search effects of various air pollutants using GIS-based modeling on the rate of hospitalizations due to asthma in children in Tehran...
August 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27664934/impaired-akt-phosphorylation-in-b-cells-of-patients-with-common-variable-immunodeficiency
#17
Reza Yazdani, Mazdak Ganjalikhani-Hakemi, Mohammad Esmaeili, Hassan Abolhassani, Shahram Vaeli, Abbas Rezaei, Zohre Sharifi, Gholamreza Azizi, Nima Rezaei, Asghar Aghamohammadi
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency characterized by recurrent infectious. We evaluated whether defective PI3K/Akt/FoxO pathway could influence B-cell fate. Determination of B-cell subsets in CVD patients and healthy donors (HDs) were performed using flow cytometry. We evaluated mRNA level and protein expression of PI3K, Akt and FoxO molecules using real-time PCR and flow cytometry, respectively. Moreover, phosphorylated Akt (p-Akt) expression in B-cells has also been measured by flowcytometry...
September 21, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27660198/pd-1-pd-l-and-autoimmunity-a-growing-relationship
#18
Mohammad Reza Zamani, Saeed Aslani, Arash Salmaninejad, Mohammad Reza Javan, Nima Rezaei
Programmed death 1 (PD-1) and its ligands, namely PD-L1 and PD-L2, are one of the key factors responsible for inhibitory T cell signaling, mediating the mechanisms of tolerance and providing immune homeostasis. Mounting evidence demonstrates that impaired PD-1:PD-L function plays an important role in a variety of autoimmune diseases such as Type 1 diabetes (T1D), encephalomyelitis, inflammatory bowel diseases (IBD), Rheumatoid Arthritis (RA), autoimmune hepatitis (AIH), Behcet's disease (BD), myasthenia gravis (MG), autoimmune uveitis (AU), Sjögren's syndrome (SjS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), myocarditis, and ankylosing spondylitis (AS)...
September 15, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27648512/vaccine-derived-polioviruses-and-children-with-primary-immunodeficiency-iran-1995-2014
#19
Mohammadreza Shaghaghi, Shohreh Shahmahmoodi, Hassan Abolhassani, Saeed Soleyman-Jahi, Leila Parvaneh, Sussan Mahmoudi, Zahra Chavoshzadeh, Reza Yazdani, Seyed Mohsen Zahraei, Mohsen Ebrahimi, Mohammad H Eslamian, Hamideh Tabatabaie, Maryam Yousefi, Yaghoob M Kandelousi, Aliasghar Oujaghlou, Nima Rezaei, Asghar Aghamohammadi
Widespread use of oral poliovirus vaccine has led to an ≈99.9% decrease in global incidence of poliomyelitis (from ≈350,000 cases in 1988 to 74 cases in 2015) and eradication of wild-type poliovirus serotypes 2 and 3. However, patients with primary immunodeficiency might shed vaccine-derived polioviruses (VDPVs) for an extended period, which could pose a major threat to polio eradication programs. Since 1995, sixteen VDPV populations have been isolated from 14 patients with immunodeficiency in Iran. For these patients, vaccine-associated paralysis, mostly in >1 extremity, was the first manifestation of primary immunodeficiency...
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27646136/association-of-interleukin-6-single-nucleotide-polymorphisms-with-juvenile-idiopathic-arthritis
#20
Vahid Ziaee, Marzieh Maddah, Mohammad-Hassan Moradinejad, Arezou Rezaei, Samaneh Zoghi, Maryam Sadr, Sara Harsini, Nima Rezaei
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children. Genetics and inflammatory elements seem to act as major underlying factors in its pathogenesis. The aim of this study is to identify the associations between interleukin-6 (IL-6) gene polymorphisms and individuals' vulnerability to JIA in a group of Iranian pediatric patients. Fifty-four patients with JIA were enrolled in this investigation and compared with 139 healthy individuals. Using polymerase chain reaction with sequence-specific primers, cytokine genotyping was performed...
September 20, 2016: Clinical Rheumatology
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