keyword
https://read.qxmd.com/read/38517409/role-of-long-non-coding-rnas-in-cholangiocarcinoma-a-systematic-review-and-meta-analysis
#1
REVIEW
Parnian Shobeiri, Razman Arabzadeh Bahri, Mohamad Mehdi Khadembashiri, Mohamad Amin Khadembashiri, Saba Maleki, Mohammad Eslami, Marzie Khalili Dehkordi, Amir Hossein Behnoush, Nima Rezaei
BACKGROUND: Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non-coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically. METHODS: International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA...
March 2024: Cancer reports
https://read.qxmd.com/read/38488239/biologic-therapy-in-pediatric-chronic-rhinosinusitis-a-systematic-review
#2
REVIEW
Sara Rahavi-Ezabadi, Sheng Zhou, Stella E Lee, Elisabeth Ference, Anthony Magit, Shelby Leuin, Kawthar Mohamed, Nima Rezaei, Vijay A Patel
OBJECTIVE: Provide clinicians with current evidence for biologic therapy in children with chronic rhinosinusitis with nasal polyposis (CRSwNP). DATA SOURCES: PubMed, MEDLINE, Cochrane, and clinical trial registries. REVIEW METHODS: Key search terms related to biologic therapy in pediatric CRSwNP were identified via a structured query of current medical literature and clinical trial databases. CONCLUSIONS: There is a dearth of active clinical trials and research studies for biologics targeting pediatric CRSwNP...
March 15, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38462281/opportunities-and-challenges-of-artificial-intelligence-and-distributed-systems-to-improve-the-quality-of-healthcare-service
#3
REVIEW
Sarina Aminizadeh, Arash Heidari, Mahshid Dehghan, Shiva Toumaj, Mahsa Rezaei, Nima Jafari Navimipour, Fabio Stroppa, Mehmet Unal
The healthcare sector, characterized by vast datasets and many diseases, is pivotal in shaping community health and overall quality of life. Traditional healthcare methods, often characterized by limitations in disease prevention, predominantly react to illnesses after their onset rather than proactively averting them. The advent of Artificial Intelligence (AI) has ushered in a wave of transformative applications designed to enhance healthcare services, with Machine Learning (ML) as a noteworthy subset of AI...
March 2024: Artificial Intelligence in Medicine
https://read.qxmd.com/read/38452377/the-role-of-long-noncoding-rnas-in-amyotrophic-lateral-sclerosis
#4
REVIEW
Darya Rajabi, Shaghayegh Khanmohammadi, Nima Rezaei
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with a poor prognosis leading to death. The diagnosis and treatment of ALS are inherently challenging due to its complex pathomechanism. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides involved in different cellular processes, incisively gene expression. In recent years, more studies have been conducted on lncRNA classes and interference in different disease pathologies, showing their promising contribution to diagnosing and treating neurodegenerative diseases...
March 8, 2024: Reviews in the Neurosciences
https://read.qxmd.com/read/38403091/biomimetic-nanotechnology-for-cancer-immunotherapy-state-of-the-art-and-future-perspective
#5
REVIEW
Alireza Sarkar Lotfabadi, Banafshe Abadi, Nima Rezaei
Cancer continues to be a significant worldwide cause of mortality. This underscores the urgent need for novel strategies to complement and overcome the limitations of conventional therapies, such as imprecise targeting and drug resistance. Cancer Immunotherapy utilizes the body's immune system to target malignant cells, reducing harm to healthy tissue. Nevertheless, the efficacy of immunotherapy exhibits variation across individuals and has the potential to induce autoimmune responses. Biomimetic nanoparticles (bNPs) have transformative potential in cancer immunotherapy, promising improved accurate targeting, immune system activation, and resistance mechanisms, while also reducing the occurrence of systemic autoimmune side effects...
February 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38347675/inflammation-and-oxidative-stress-in-epileptic-children-from-molecular-mechanisms-to-clinical-application-of-ketogenic-diet
#6
REVIEW
Azam Ildarabadi, Seyedeh Nooshan Mir Mohammad Ali, Fatemeh Rahmani, Narjes Mosavari, Elham Pourbakhtyaran, Nima Rezaei
Childhood epilepsy affects up to 1 % of children. It has been shown that 30 % of patients are resistant to drug treatments, making further investigation of other potential treatment strategies necessary. One such approach is the ketogenic diet (KD) showing promising results and potential benefits beyond the use of current antiepileptic drugs. This study aims to investigate the effects of KD on inflammation and oxidative stress, as one of the main suggested mechanisms of neuroprotection, in children with epilepsy...
February 14, 2024: Reviews in the Neurosciences
https://read.qxmd.com/read/38332930/sars-cov-2-omicron-ba-4-ba-5-variant-lessons-learned-from-a-new-variant-during-the-covid-19-pandemic
#7
JOURNAL ARTICLE
Gisou Erabi, Arezoo Faridzadeh, Ali Parvin, Niloofar Deravi, Mohammad Rahmanian, Mobina Fathi, Elahe Aleebrahim-Dehkordi, Nima Rezaei
BACKGROUND AND AIM: In late 2021, the world faced the rapid spread of the SARS-CoV-2 Omicron variant, which quickly became the variant of concern. In April 2022, two new lineages of Omicron (BA.4/BA.5) emerged from Africa, where they caused the fifth wave of infection. METHOD: We searched PubMed, Google Scholar, and Scopus online databases up to December 2023 for founding relevant studies. RESULTS: BA.4 and BA.5 subgroups, with changes in the spike protein, have a greater ability to escape from the immune system, which was possible with the help of L452R and F486V mutations...
February 2024: Health Science Reports
https://read.qxmd.com/read/38317174/the-progressive-trend-of-modeling-and-drug-screening-systems-of-breast-cancer-bone-metastasis
#8
REVIEW
Hanieh Kolahi Azar, Maliheh Gharibshahian, Mohammadreza Rostami, Vahid Mansouri, Leila Sabouri, Nima Beheshtizadeh, Nima Rezaei
Bone metastasis is considered as a considerable challenge for breast cancer patients. Various in vitro and in vivo models have been developed to examine this occurrence. In vitro models are employed to simulate the intricate tumor microenvironment, investigate the interplay between cells and their adjacent microenvironment, and evaluate the effectiveness of therapeutic interventions for tumors. The endeavor to replicate the latency period of bone metastasis in animal models has presented a challenge, primarily due to the necessity of primary tumor removal and the presence of multiple potential metastatic sites...
February 5, 2024: Journal of Biological Engineering
https://read.qxmd.com/read/38316078/risk-of-ms-relapse-and-deterioration-after-covid-19-a-systematic-review-and-meta-analysis
#9
REVIEW
Homa Seyedmirzaei, Dorsa Salabat, Sara KamaliZonouzi, Antônio L Teixeira, Nima Rezaei
BACKGROUND: Upper respiratory viral infections have long been considered triggers for multiple sclerosis (MS) relapse and exacerbation. The possible effects of SARS-CoV-2 infection on MS relapse and deterioration remain controversial. METHODS: We systematically searched PubMed, Scopus, Embase, Cochrane, and Web of Science databases to find relevant studies assessing changes in relapse rates or Expanded Disability Status Scale (EDSS) following COVID-19 in people with MS...
March 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38279762/lrrk2-communicative-role-in-the-treatment-of-parkinson-s-disease-and-ulcerative-colitis-overlapping
#10
JOURNAL ARTICLE
Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Amirhossein Niknejad, Hedieh Sadat Shamsnia, Maryam Shayan, Leila Mohaghegh Shalmani, Saeideh Momtaz, Nima Rezaei, Amir Hossein Abdolghaffari
BACKGROUND: Involvement of gastrointestinal inflammation in Parkinson's disease (PD) pathogenesis and movement have progressively emerged. Inflammation is involved in the etiology of both PD and inflammatory bowel disease (IBD). Transformations in leucine-rich recurrent kinase 2 (LRRK2) are among the best hereditary supporters of IBD and PD. Elevated levels of LRRK2 have been reported in stimulated colonic tissue from IBD patients and peripheral invulnerable cells from irregular PD patients; thus, it is thought that LRRK2 directs inflammatory cycles...
January 25, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38270744/stem-cell-based-regenerative-approaches-for-the-treatment-of-cleft-lip-and-palate-a-comprehensive-review
#11
REVIEW
Helia Sharif, Heliya Ziaei, Nima Rezaei
Cleft lip and/or palate (CLP) is a prevalent congenital craniofacial abnormality that can lead to difficulties in eating, speaking, hearing, and psychological distress. The traditional approach for treating CLP involves bone graft surgery, which has limitations, post-surgical complications, and donor site morbidity. However, regenerative medicine has emerged as a promising alternative, employing a combination of stem cells, growth factors, and scaffolds to promote tissue regeneration. This review aims to provide a comprehensive overview of stem cell-based regenerative approaches in the management of CLP...
January 25, 2024: Stem cell reviews and reports
https://read.qxmd.com/read/38267724/blood-and-csf-levels-of-brain-derived-neurotrophic-factor-in-patients-with-encephalopathy-encephalitis-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Fatemeh Nikpour, Amir Salimi, Amene Saghazadeh, Nima Rezaei
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is critical for enhancing the survival and growth of neurons and modulating the synaptic plasticity. BDNF levels have been demonstrated to be changed in plasma and cerebrospinal fluid (CSF) following brain insults such as inflammation or ischemia or infection in several studies. Currently, there is no systematic review regarding BDNF levels in encephalitis or encephalopathy patients. Considering inconsistency between studies, we aimed to pool the data from existing studies to determine whether blood or CSF levels of BDNF are different in patients with encephalopathy/encephalitis...
January 24, 2024: Acta Neurologica Belgica
https://read.qxmd.com/read/38229141/risk-of-flare-or-relapse-in-patients-with-immune-mediated-diseases-following-sars-cov-2-vaccination-a-systematic-review-and-meta-analysis
#13
REVIEW
Mahya Shabani, Parnian Shobeiri, Shadi Nouri, Zahra Moradi, Robel Assefa Amenu, Mohammad-Mehdi Mehrabi Nejad, Nima Rezaei
BACKGROUND: Patients with autoimmune and immune-mediated diseases (AI-IMD) are at greater risk of COVID-19 infection; therefore, they should be prioritized in vaccination programs. However, there are concerns regarding the safety of COVID-19 vaccines in terms of disease relapse, flare, or exacerbation. In this study, we aimed to provide a more precise and reliable vision using systematic review and meta-analysis. METHODS: PubMed-MEDLINE, Embase, and Web of Science were searched for original articles reporting the relapse/flare in adult patients with AI-IMD between June 1, 2020 and September 25, 2022...
January 17, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38226452/the-role-of-toll-like-receptors-in-neuropsychiatric-disorders-immunopathology-treatment-and-management
#14
REVIEW
Kiarash Saleki, Parsa Alijanizadeh, Nima Javanmehr, Nima Rezaei
Neuropsychiatric disorders denote a broad range of illnesses involving neurology and psychiatry. These disorders include depressive disorders, anxiety, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorders, headaches, and epilepsy. In addition to their main neuropathology that lies in the central nervous system (CNS), lately, studies have highlighted the role of immunity and neuroinflammation in neuropsychiatric disorders. Toll-like receptors (TLRs) are innate receptors that act as a bridge between the innate and adaptive immune systems via adaptor proteins (e...
January 16, 2024: Medicinal Research Reviews
https://read.qxmd.com/read/38194459/conversion-of-monoclonal-igg-to-dimeric-and-secretory-iga-restores-neutralizing-ability-and-prevents-infection-of-omicron-lineages
#15
JOURNAL ARTICLE
Harold Marcotte, Yunlong Cao, Fanglei Zuo, Luca Simonelli, Josè Camilla Sammartino, Mattia Pedotti, Rui Sun, Irene Cassaniti, Marie Hagbom, Antonio Piralla, Jinxuan Yang, Likun Du, Elena Percivalle, Federico Bertoglio, Maren Schubert, Hassan Abolhassani, Natalia Sherina, Concetta Guerra, Stephan Borte, Nima Rezaei, Makiko Kumagai-Braesch, Yintong Xue, Chen Su, Qihong Yan, Ping He, Caroline Grönwall, Lars Klareskog, Luigi Calzolai, Andrea Cavalli, Qiao Wang, Davide F Robbiani, Michael Hust, Zhengli Shi, Liqiang Feng, Lennart Svensson, Ling Chen, Linlin Bao, Fausto Baldanti, Junyu Xiao, Chuan Qin, Lennart Hammarström, Xinglou Yang, Luca Varani, Xiaoliang Sunney Xie, Qiang Pan-Hammarström
The emergence of Omicron lineages and descendent subvariants continues to present a severe threat to the effectiveness of vaccines and therapeutic antibodies. We have previously suggested that an insufficient mucosal immunoglobulin A (IgA) response induced by the mRNA vaccines is associated with a surge in breakthrough infections. Here, we further show that the intramuscular mRNA and/or inactivated vaccines cannot sufficiently boost the mucosal secretory IgA response in uninfected individuals, particularly against the Omicron variant...
January 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38193829/long-non-coding-rna-as-a-potential-diagnostic-and-prognostic-biomarker-in-melanoma-a-systematic-review-and-meta-analysis
#16
REVIEW
Mahdi Masrour, Shaghayegh Khanmohammadi, Parisa Fallahtafti, Seyedeh Melika Hashemi, Nima Rezaei
Recently, long noncoding RNAs (lncRNAs) have been applied as biomarkers for melanoma patients. In this systematic review and meta-analysis, we investigated the diagnostic and prognostic value of lncRNAs. We used the keywords 'lncRNA' and 'melanoma' to search databases for studies published before June 14th, 2023. The specificity, sensitivity and AUC were utilized to assess diagnostic accuracy and the prognostic value was assessed using overall survival, progression-free survival and disease-free survival hazard ratios...
January 9, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38184287/clinical-heterogeneity-in-families-with-multiple-cases-of-inborn-errors-of-immunity
#17
JOURNAL ARTICLE
Samaneh Delavari, Seyed Erfan Rasouli, Saba Fekrvand, Zahra Chavoshzade, Seyed Alireza Mahdaviani, Paniz Shirmast, Samin Sharafian, Roya Sherkat, Tooba Momen, Soheila Aleyasin, Hamid Ahanchian, Mahnaz Sadeghi-Shabestari, Hossein Esmaeilzadeh, Sahar Barzamini, Fateme Tarighatmonfared, Helia Salehi, Marzie Esmaeili, Zahra Marzani, Nazanin Fathi, Farhad Abolnezhadian, Mina Kianmanesh Rad, Ali Saeedi-Boroujeni, Afshin Shirkani, Zahra Bagheri, Fereshte Salami, Tannaz Moeini Shad, Mahsa Yousefpour Marzbali, Hanieh Mojtahedi, Azadehsadat Razavi, Naeimeh Tavakolinia, Taher Cheraghi, Marzieh Tavakol, Alireza Shafiei, Nasrin Behniafard, Sare Sadat Ebrahimi, Najmeh Sepahi, Amirhossein Ghaneimoghadam, Arezou Rezaei, Arash Kalantari, Hassan Abolhassani, Nima Rezaei
BACKGROUND: Inborn errors of immunity (IEI) are a diverse range of genetic immune system illnesses affecting the innate and/or adaptive immune systems. Variable expressivity and incomplete penetrance have been reported in IEI patients with similar clinical diagnoses or even the same genetic mutation. METHODS: Among all recorded patients in the national IEI registry, 193 families with multiple cases have been recognized. Clinical, laboratory and genetic variability were compared between 451 patients with different IEI entities...
January 4, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38157855/human-inherited-ccr2-deficiency-underlies-progressive-polycystic-lung-disease
#18
JOURNAL ARTICLE
Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasco, Camille Soudée, Corentin Le Floc'h, Mélanie Migaud, Yoann Seeleuthner, Mi-Sun Jang, Eirini Nikolouli, Simin Seyedpour, Hugues Begueret, Jean-François Emile, Pierre Le Guen, Guido Tavazzi, Costanza Natalia Julia Colombo, Federico Capra Marzani, Micol Angelini, Francesca Trespidi, Stefano Ghirardello, Nasrin Alipour, Anne Molitor, Raphael Carapito, Mohsen Mazloomrezaei, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Chantal Brouzes, Pablo Vargas, Alessandro Borghesi, Nico Lachmann, Seiamak Bahram, Bruno Crestani, Susanta Pahari, Larry S Schlesinger, Nico Marr, Dusan Bugonovic, Stéphanie Boisson-Dupuis, Vivien Béziat, Laurent Abel, Raphael Borie, Lisa R Young, Robin Deterding, Mohammad Shahrooei, Nima Rezaei, Nima Parvaneh, Daniel Craven, Philippe Gros, Danielle Malo, Fernando E Sepulveda, Lawrence M Nogee, Nathalie Aladjidi, Bruce C Trapnell, Jean-Laurent Casanova, Jacinta Bustamante
We describe a human lung disease caused by autosomal recessive, complete deficiency of the monocyte chemokine receptor C-C motif chemokine receptor 2 (CCR2). Nine children from five independent kindreds have pulmonary alveolar proteinosis (PAP), progressive polycystic lung disease, and recurrent infections, including bacillus Calmette Guérin (BCG) disease. The CCR2 variants are homozygous in six patients and compound heterozygous in three, and all are loss-of-expression and loss-of-function. They abolish CCR2-agonist chemokine C-C motif ligand 2 (CCL-2)-stimulated Ca2+ signaling in and migration of monocytic cells...
December 20, 2023: Cell
https://read.qxmd.com/read/38147741/the-regulatory-role-of-bdnf-in-neuroimmune-axis-function-and-neuroinflammation-induced-by-chronic-stress-a-new-therapeutic-strategies-for-neurodegenerative-disorders
#19
REVIEW
Masoomeh Dadkhah, Milad Baziar, Nima Rezaei
Neurodegenerative disorders account for a high proportion of neurological diseases that significantly threaten public health worldwide. Various factors are involved in the pathophysiology of such diseases which can lead to neurodegeneration and neural damage. Furthermore, neuroinflammation is a well-known factor in predisposing factors of neurological and especially neurodegenerative disorders which can be strongly suppressed by "anti-inflammatory" actions of brain-derived neurotrophic factor (BDNF). Stress has has also been identified as a risk factor in developing neurodegenerative disorders potentially leading to increased neuroinflammation in the brain and progressive loss in neuronal structures and impaired functions in the CNS...
December 25, 2023: Cytokine
https://read.qxmd.com/read/38146112/whole-exome-sequencing-to-identify-undiagnosed-primary-immunodeficiency-disorders-in-children-with-community-acquired-sepsis-admitted-in-the-pediatric-intensive-care-unit
#20
JOURNAL ARTICLE
Elham Rayzan, Mona Mirbeyk, Parmida Sadat Pezeshki, Masoud Mohammadpour, Bahareh Yaghmaie, Seyed Abbas Hassani, Meisam Sharifzadeh, Leila Tahernia, Nima Rezaei
BACKGROUND: Whole-exome sequencing (WES) provides a powerful diagnostic tool for identifying primary immunodeficiency diseases (PIDs). This study explores the utility of this approach in uncovering previously undiagnosed PIDs in children with community-acquired sepsis (CAS), with a medical history of recurrent infections or a family history of PIDs. METHODS: We performed WES on DNA samples extracted from the blood of the 34 enrolled patients, followed by bioinformatic analysis for variant calling, annotation, and prioritization...
December 2023: Pediatric Allergy and Immunology
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