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Nima Rezaei

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https://www.readbyqxmd.com/read/29618830/evaluation-of-the-tlr-negative-regulatory-network-in-cvid-patients
#1
Roozbeh Sanaei, Nima Rezaei, Asghar Aghamohammadi, Ali-Akbar Delbandi, Shahram Teimourian, Reza Yazdani, Parsova Tavasolian, Fatemeh Kiaee, Nader Tajik
Common variable immunodeficiency (CVID), a clinically symptomatic primary immunodeficiency disease (PID), is characterized by hypogammaglobulinemia leading to recurrent infections and various complications. Recently, some defects in the signaling of TLRs have been identified in CVID patients which led us to investigate the expression of TLR4 and 9 negative regulatory molecules and their upregulation status following their activation. Using TaqMan real-time PCR, SOCS1, TNFAIP3, RFN216, and IRAK-M transcripts among peripheral blood mononuclear cells (PBMCs) were measured with/without TLR4 and 9 activations...
April 5, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29574662/evaluation-of-regulatory-t-lymphocytes-and-il2ra-and-foxp3-gene-expression-in-peripheral-mononuclear-cells-from-patients-with-amyotrophic-lateral-sclerosis
#2
Sara Rashid Chehreh Bargh, Abbas Tafakhori, Farimah Masoumi, Farzaneh Rahmani, Mona Ahmadi, Afshin Namdar, Maryam Azimi, Parsova Tavasolian, Sima Habibi, Babak Zamani, Marziyeh Maserrat, Maryam Sadr, Farshid Noorbakhsh, Nima Rezaei
BACKGROUND: Loss of neuroprotective role of CD4+ helper T cells, regulatory T cells, and M2 microglia constitutively results in the rapid neural death in the "rapidly progressive phase" of amyotrophic lateral sclerosis (ALS). AIM: We aimed to investigate relative count of CD4+ and regulatory T lymphocytes and expression level of IL2Ra and FOXP3 genes in peripheral blood mononuclear cells (PBMCs) from patients with ALS. METHOD: We performed a flow cytometric analysis on PBMC from 38 patients with ALS and 32 controls to determine the count of CD4+ and CD4+ CD25+ cells...
March 25, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29569511/radioimmunotherapy-as-the-first-line-of-treatment-in-non-hodgkin-lymphoma
#3
Mahsa Eskian, MirHojjat Khorasanizadeh, Pier L Zinzani, Nima Rezaei
Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy. The estimated deaths and new cases of NHL in the USA in 2018 have reached 19,910 and 74,680, respectively, with 5-year survival rate of 71%. Therapeutic interventions for NHL consist of chemotherapy, radiation therapy and immunotherapy. Radioimmunotherapy (RIT) is a potential alternative treatment for NHL that is currently used in different lines of treatment. Studies show that nuclear medicine physicians and radiation oncologists are not yet certain about the proper line for administration of RIT...
March 23, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29528757/polyautoimmunity-in-patients-with-lps-responsive-beige-like-anchor-lrba-deficiency
#4
Gholamreza Azizi, Hassan Abolhassani, Majid Zaki-Dizaji, Sima Habibi, Hamed Mohammadi, Mohammadreza Shaghaghi, Reza Yazdani, Juan-Manuel Anaya, Nima Rezaei, Lennart Hammarström, Asghar Aghamohammadi
BACKGROUND: Polyautoimmunity is defined as the presence of more than one autoimmune disorder in a single patient. Lipopolysaccharide (LPS)-responsive beige-like anchor (LRBA) deficiency is one of the monogenic causes of polyautoimmunity. The aim of this study was to report the characteristics of polyautoimmunity in patients with LRBA deficiency. METHODS: A total of 14 LRBA deficiency patients with confirmed autoimmunity were enrolled in this study. For those patients with polyautoimmunity, demographic information, clinical records, laboratory, and molecular data were collected...
March 12, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29509545/neurological-and-psychiatric-disorders-in-psoriasis
#5
Man Amanat, Mona Salehi, Nima Rezaei
Psoriasis used to be known as a skin disorder; however, it can now be considered as a systemic disease with the involvement of multiple organs. Neurological and psychiatric disorders are some of the associated problems that can be observed in patients with psoriasis. Stroke, multiple sclerosis, seizure, migraine, restless leg syndrome, Parkinson's disease, Guillain-Barré syndrome, and myasthenia gravis are the reported neurological diseases, while depression, bipolar mood disorder, anxiety, psychosis, cognitive impairment, personality disorders, sexual disorders, sleep disturbance, and eating disorders are the recognized psychiatric presentations in patients with psoriasis...
March 6, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29478755/new-insights-into-physiopathology-of-immunodeficiency-associated-vaccine-derived-poliovirus-infection-systematic-review-of-over-5-decades-of-data
#6
REVIEW
Mohammadreza Shaghaghi, Saeed Soleyman-Jahi, Hassan Abolhassani, Reza Yazdani, Gholamreza Azizi, Nima Rezaei, Mohamed-Ridha Barbouche, Mark A McKinlay, Asghar Aghamohammadi
Widespread administration of oral poliovirus vaccine (OPV) has decreased global incidence of poliomyelitis by ≈99.9%. However, the emergence of vaccine-derived polioviruses (VDPVs) is threatening polio-eradication program. Primary immunodeficiency (PID) patients are at higher risks of vaccine-associated paralytic poliomyelitis (VAPP) and prolonged excretion of immunodeficiency-associated VDPV (iVDPV). We searched Embase, Medline, Science direct, Scopus, Web of Science, and CDC and WHO databases by 30 September 2016, for all reports of iVDPV cases...
February 22, 2018: Vaccine
https://www.readbyqxmd.com/read/29458167/autosomal-dominant-deficiency-of-the-interleukin-17f-in-recurrent-aphthous-stomatitis-possible-novel-mutation-in-a-new-entity
#7
Alireza Zare Bidoki, Ahmad Massoud, Shamsolmoulouk Najafi, Mahsa Mohammadzadeh, Nima Rezaei
Recurrent Aphthous Stomatitis (RAS) is a common oral inflammatory disease with unknown pathogenesis. Although the immune system alterations could be involved in predisposition of individuals to oral candidiasis, precise etiologies of RAS have not been understood yet. A recent study showed that autosomal dominant IL17F deficiency could cause chronic mucocutaneous candidiasis. Considering the inflammatory nature of interleukin (IL)-17F and RAS, this study was performed to check any disease-associated mutation in a number of patients with RAS...
February 16, 2018: Gene
https://www.readbyqxmd.com/read/29436788/universal-scientific-education-and-research-network-usern-twinkling-stars-unite-to-make-the-world-glow
#8
Nima Rezaei
No abstract text is available yet for this article.
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29427743/the-role-of-latency-reversal-agents-in-the-cure-of-hiv-a-review-of-current-data
#9
REVIEW
Kiandokht Bashiri, Nima Rezaei, Milena Nasi, Andrea Cossarizza
The definitive cure for human immunodeficiency virus type-1 (HIV) infection is represented by the eradication of the virus from the patient's body. To reach this result, cells that are infected but do not produce the virus must become recognizable to be killed by the immune system. For this purpose, drugs defined "latency reverting agents" (LRA) that reactivate viral production are under investigation. A few clinical studies have been performed in HIV-infected patients treated with LRA and combined antiretroviral therapy (cART)...
February 7, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29423720/association-of-interferon-regulatory-factor-5-irf5-gene-polymorphisms-with-juvenile-idiopathic-arthritis
#10
Samira Esmaeili Reykande, Arezou Rezaei, Maryam Sadr, Mahsima Shabani, Farnaz Najmi Varzaneh, Vahid Ziaee, Nima Rezaei
Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play a fundamental role in its pathogenesis. In this study, we aimed to assess the association of IRF5 gene polymorphisms with susceptibility of JIA in Iranian population. Three IRF5 single-nucleotide polymorphisms (rs10954213 A/G, rs2004640 G/T, and rs3807306 G/T) were genotyped using TaqMan assays in 55 patients with JIA and 63 matched healthy individuals...
February 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29417068/internationalization-or-globalization-of-higher-education
#11
REVIEW
Habibolah Rezaei, Alireza Yousefi, Bagher Larijani, Reza Dehnavieh, Nima Rezaei, Peyman Adibi
INTRODUCTION: Studies about globalization and internationalization demonstrate different attitudes in explaining these concepts. Since there is no consensus among Iranian specialists about these concepts, the purpose of this study is to explain the concepts of internationalization and globalization in Iran. MATERIALS AND METHODS: This study is a systematic review done in the first half of 2016. To explain the concept of globalization and internationalization, articles in Scientific Information D atabase, Magiran database, and Google Scholar were searched with the keywords such as globalization, scientific exchange, international cooperation, curriculum exchange, student exchange, faculty exchange, multinational cooperation, transnational cooperation, and collaborative research...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29392424/minimal-residual-disease-mrd-detection-using-rearrangement-of-immunoglobulin-t-cell-receptor-genes-in-adult-patients-with-acute-lymphoblastic-leukemia-all
#12
Sepideh Shahkarami, Roya Mehrasa, Samareh Younesian, Marjan Yaghmaie, Bahram Chahardouli, Mohammad Vaezi, Nima Rezaei, Mohsen Nikbakht, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Javad Tavakkoly-Bazzaz, Seyed H Ghaffari
MRD detection with allele-specific oligonucleotide-quantitative polymerase chain reaction (ASO-qPCR) and using clone-specific immunoglobulin/T cell receptor rearrangements is considered as a powerful prognostic factor in acute lymphoblastic leukemia (ALL). In the present study, we evaluated an ASO-qPCR assay for MRD quantification in peripheral blood (PB) samples of adult patients with ALL. DNA was isolated from PB samples of patients with newly diagnosed ALL. They were first investigated by multiplex-PCR assay to identify V/J usage...
April 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29373878/brain-derived-neurotrophic-factor-role-in-autism-remains-elusive-a-flashback-on-the-route-that-has-brought-us-here
#13
Farzaneh Rahmani, Nima Rezaei
No abstract text is available yet for this article.
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373197/the-role-of-inflammatory-cytokines-and-tumor-associated-macrophages-tams-in-microenvironment-of-pancreatic-cancer
#14
REVIEW
Saeed Farajzadeh Valilou, Mahsa Keshavarz-Fathi, Nicola Silvestris, Antonella Argentiero, Nima Rezaei
Pancreatic cancer is considered as one of the most lethal types of cancer due to its poor prognosis and lack of effective therapeutic approaches. Although many studies have been done on pancreatic cancer, the current treatment methods did not exhibit successful results. Hence, novel strategies are needed for treatment of pancreatic cancer. The microenvironment of pancreatic cancer contains many factors such as inflammatory cytokines and tumor associated macrophages (TAMs), which influence the tumor's status...
January 12, 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29346446/osteopontin-opn-as-a-csf-and-blood-biomarker-for-multiple-sclerosis-a-systematic-review-and-meta-analysis
#15
REVIEW
Elmira Agah, Arshia Zardoui, Amene Saghazadeh, Mona Ahmadi, Abbas Tafakhori, Nima Rezaei
Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid (CSF) and peripheral blood concentration of osteopontin (OPN) may have diagnostic and prognostic value in MS. We conducted a systematic review and meta-analysis of studies that measured peripheral blood and CSF levels of OPN in MS patients and controls to evaluate the diagnostic potential of this biomarker better. We searched PubMed, Web of Science and Scopus databases to find articles that measured OPN concentration in peripheral blood and CSF samples from MS patients up to October 19, 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29344529/internationalization-of-medical-education-in-iran-a-way-towards-implementation-of-the-plans-of-development-and-innovation-in-medical-education
#16
Ehsan Shamsi Gooshki, Ata Pourabbasi, Hamid Akbari, Nima Rezaei, Ali Arab Kheradmand, Zahra Kheiry, Niloufar Peykari, Fatereh Momeni Javid, Firouzeh Hajipour, Bagher Larijani
Introduction: Academic institutions are the most important organizations for implementation of internationalization policies and practices for integrating an international, intercultural and global dimension in higher education system. Also, a globally increasing demand for higher education has been seen in the past two decades so that the number of students enrolled in higher education institutions in the worldwide nation-states has increased dramatically. The National Plan of International Development of Medical Education was designed with the aim of identifying available potentials in all the universities of medical sciences, encouraging the development of international standards of medical education, and planning for the utilization of the existing capacity in Islamic republic of Iran...
January 2018: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/29336634/sicam-1-svcam-1-and-se-selectin-levels-in-type-1-diabetes
#17
Anwar Fathollahi, Ahmad Massoud, Ali Akbar Amirzargar, Babak Aghili, Ensieh Nasli Esfahani, Nima Rezaei
BACKGROUND/OBJECTIVE: This study was performed to compare soluble levels of adhesion molecules between diabetic patients and controls and to assess their possible association with long-term complications of type 1 diabetes (T1D). METHODS: Forty-eight patients with T1D and 39 healthy controls were enrolled in this study. The plasma level of adhesion molecules was measured by sandwich enzyme-linked immunosorbent assay technique. RESULTS: Higher sVCAM 1 (soluble vascular cell adhesion molecule 1) levels correlated with older age of onset of T1D...
February 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29320366/therapeutic-efficacy-of-specific-immunotherapy-for-glioma-a-systematic-review-and-meta-analysis
#18
Sara Hanaei, Khashayar Afshari, Armin Hirbod-Mobarakeh, Bahram Mohajer, Delara Amir Dastmalchi, Nima Rezaei
Although different immunotherapeutic approaches have been developed for the treatment of glioma, there is a discrepancy between clinical trials limiting their approval as common treatment. So, the current systematic review and meta-analysis were conducted to assess survival and clinical response of specific immunotherapy in patients with glioma. Generally, seven databases were searched to find eligible studies. Controlled clinical trials investigating the efficacy of specific immunotherapy in glioma were found eligible...
January 10, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29296268/association-of-serotonin-transporter-gene-polymorphism-with-recurrent-aphthous-stomatitis
#19
Shamsolmolouk Najafi, Mahsa Mohammadzadeh, Amirabbas Zahedi, Mansour Heidari, Nima Rezaei
Background: Recurrent Aphthous Stomatitis (RAS) is one of the most common diseases of the oral cavity all over the world (5-66%). RAS has a multifactorial etiology, while psychological factors such as stress and anger play a role in its manifestation. The serotonergic mechanisms particularly the serotonin-transporter gene ( 5-HTT ) may affect the risk of psychological alterations and stress response. The aim of the present study was to evaluate the polymorphism of the promoter region of 5-HTT ( 5-HTTLPR ) in the patients with RAS, compared to that in the control subjects...
January 2018: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29288368/single-nucleotide-polymorphism-of-methyl-cpg-binding-protein-2-gene-associates-with-juvenile-idiopathic-arthritis
#20
Mahdi Mahmoudi, Elham Hamzeh, Saeed Aslani, Vahid Ziaee, Shiva Poursani, Nima Rezaei
Methyl-CpG-binding protein 2 (MeCP2) is a transcription suppressor or activator, acting through binding to methylated DNA. Numerous investigations have established a role for methylation aberrancies in the pathogenesis of autoimmune disorders. Single nucleotide polymorphisms (SNPs) in MECP2 gene have been implicated with susceptibility to rheumatoid arthritis (RA). Here, the plausible association of MECP2 gene polymorphisms was evaluated with juvenile idiopathic arthritis (JIA) predisposition in Iranian pediatric patients...
February 2018: Clinical Rheumatology
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