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https://www.readbyqxmd.com/read/29793174/effect-of-ca-2-ion-concentration-on-adsorption-of-poly-carboxylate-ether-based-pce-superplasticizer-on-mica
#1
Bo Wu, Byong-Wa Chun, Le Gu, Tonya L Kuhl
HYPOTHESIS: Poly(carboxylate ether)-based (PCE) superplasticizers consist of a carboxylic acid backbone and grafted poly(ethylene glycol) (PEG) side chains. Ca2+ ion bridging mechanism is commonly purported to control PCE's adsorption on negatively charged cement particle surfaces in cement suspension, thus PCE was expected to adsorb on negatively charged surfaces in synthetic pore solutions via Ca2+ /COO- interactions. EXPERIMENTS: Adsorption behaviors of a commercial PCE on negatively charged mica were studied in aqueous electrolyte solutions by a surface forces apparatus...
May 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793169/spontaneous-rise-in-open-rectangular-channels-under-gravity
#2
Vignesh Thammanna Gurumurthy, Ilia V Roisman, Cameron Tropea, Stephen Garoff
Fluid movement in microfluidic devices, porous media, and textured surfaces involves coupled flows over the faces and corners of the media. Spontaneous wetting of simple grooved surfaces provides a model system to probe these flows. This numerical study investigates the spontaneous rise of a liquid in an array of open rectangular channels under gravity, using the Volume-of-Fluid method with adaptive mesh refinement. The rise is characterized by the meniscus height at the channel center, outer face and the interior and exterior corners...
May 17, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793157/energy-dissipation-in-quasi-linear-viscoelastic-tissues-cells-and-extracellular-matrix
#3
Behzad Babaei, A J Velasquez-Mao, Kenneth M Pryse, William B McConnaughey, Elliot L Elson, Guy M Genin
Characterizing how a tissue's constituents give rise to its viscoelasticity is important for uncovering how hidden timescales underlie multiscale biomechanics. These constituents are viscoelastic in nature, and their mechanics must typically be assessed from the uniaxial behavior of a tissue. Confounding the challenge is that tissue viscoelasticity is typically associated with nonlinear elastic responses. Here, we experimentally assessed how fibroblasts and extracellular matrix (ECM) within engineered tissue constructs give rise to the nonlinear viscoelastic responses of a tissue...
May 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29793102/joint-attention-in-down-syndrome-a-meta-analysis
#4
REVIEW
Laura J Hahn, Susan J Loveall, Madison T Savoy, Allie M Neumann, Toshikazu Ikuta
BACKGROUND: Some studies have indicated that joint attention may be a relative strength in Down syndrome (DS), but other studies have not. AIM: To conduct a meta-analysis of joint attention in DS to more conclusively determine if this is a relative strength or weakness when compared to children with typical development (TD), developmental disabilities (DD), and autism spectrum disorder (ASD). METHODS AND PROCEDURES: Journal articles published before September 13, 2016, were identified by using the search terms "Down syndrome" and "joint attention" or "coordinating attention"...
May 21, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29792965/characterization-sulfated-modification-and-bioactivity-of-a-novel-polysaccharide-from-millettia-dielsiana
#5
Zhonghua Wang, Tongqiang Cai, Xipu He
Millettia dielsiana is a traditional herb medicine to treat rheumatic arthritis and gynecological diseases. In this study, a novel polysaccharide (MDP1) with a molecular weight of 139.54 kDa was isolated from Millettia dielsiana by DEAE-52 cellulose chromatography. Its sulfated derivative (S-MDP1) was prepared by the chlorosulfonic acid-pyridine method. Structural analysis indicated that MDP1 was a pectic polysaccharide and did not exhibit a triple helical conformation. In vitro, MDP1 and S-MDP1 had protective effect on H2 O2 -induced PC12 cells death...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792862/the-reason-for-the-low-ca-2-sensitivity-of-thin-filaments-associated-with-the-glu41lys-mutation-in-the-tpm2-gene-is-freezing-of-tropomyosin-near-the-outer-domain-of-actin-and-inhibition-of-actin-monomer-switching-off-during-the-atpase-cycle
#6
Stanislava V Avrova, Olga E Karpicheva, Nikita A Rysev, Armen O Simonyan, Vladimir V Sirenko, Charles S Redwood, Yurii S Borovikov
The E41K mutation in TPM2 gene encoding muscle regulatory protein beta-tropomyosin is associated with nemaline myopathy and cap disease. The mutation results in a reduced Ca2+ -sensitivity of the thin filaments and in muscle weakness. To elucidate the structural basis of the reduced Ca2+ -sensitivity of the thin filaments, we studied multistep changes in spatial arrangement of tropomyosin (Tpm), actin and myosin heads during the ATPase cycle in reconstituted fibers, using the polarized fluorescence microscopy...
May 21, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29792785/two-cases-of-combined-patellar-tendon-avulsion-from-the-tibia-and-patella
#7
Viachaslau Bradko, William T Stoll, Lee S Haruno, Scott B Rosenfeld, Scott D McKay
Avulsion fractures of the inferior pole of the patella and proximal tibial apophysis are independently rare injuries. They occur in children due to the relative weakness of the apophyseal cartilage compared to the ligaments and tendons. The combination of these two fractures, is exceedingly rare, with only a few previously described cases in the literature. Due to the infrequent presentation of this injury, careful examination and consideration of advanced imaging is important for diagnosis and preoperative planning...
2018: SICOT-J
https://www.readbyqxmd.com/read/29792750/metrics-to-evaluate-quality-of-glycemic-control-comparison-of-time-in-target-hypoglycemic-and-hyperglycemic-ranges-with-risk-indices
#8
David Rodbard
OBJECTIVE: We sought to cross validate several metrics for quality of glycemic control, hypoglycemia, and hyperglycemia. RESEARCH DESIGN AND METHODS: We analyzed the mathematical properties of several metrics for overall glycemic control, and for hypo- and hyperglycemia, to evaluate their similarities, differences, and interrelationships. We used linear regression to describe interrelationships and examined correlations between metrics within three conceptual groups...
May 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29792676/dramatic-increase-in-polymer-glass-transition-temperature-under-extreme-nanoconfinement-in-weakly-interacting-nanoparticle-films
#9
Haonan Wang, Jyo Lyn Hor, Yue Zhang, Tianyi Liu, Daeyeon Lee, Zahra Fakhraai
Properties of polymers in polymer nanocomposites and nanopores have been shown to deviate from their respective bulk properties due to chain confinement as well as polymer-particle interfacial interactions. However, separating the confinement effects from the interfacial effects under extreme nanoconfinement is experimentally challenging. Capillary Rise Infiltration (CaRI) enables polymer infiltration into nanoparticle (NP) packings, thereby confining polymers within extremely small pores and dramatically increasing the interfacial area, providing a unique system to systematically distinguish the role of each effect on polymer properties...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792667/control-of-selectivity-in-palladium-ii-catalyzed-oxidative-transformations-of-allenes
#10
Bin Yang, Youai Qiu, Jan-E Bäckvall
Oxidation reactions play a central role in organic synthesis, and it is highly desirable that these reactions are mild and occur under catalytic conditions. In Nature, oxidation reactions occur under mild conditions via cascade processes, and furthermore, they often occur in an enantioselective manner with many of them involving molecular oxygen or hydrogen peroxide as the terminal oxidant. Inspired by the reactions in Nature, we have developed a number of Pd(II)-catalyzed cascade reactions under mild oxidative conditions...
May 24, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29792574/evaluation-of-a-mobile-application-for-pelvic-floor-exercises
#11
Michelle N Han, Tamara Grisales, Aparna Sridhar
BACKGROUND: Pelvic floor exercises are effective in improving muscle strength and urinary incontinence symptoms. Increasingly popular mobile applications can be effective in teaching patients these exercises. INTRODUCTION: A mobile application, Bwom© , aims to educate women about pelvic floor exercises with individually tailored plans relevant to the user's risk factors. The objective of this study is to assess the understandability and actionability of Bwom. MATERIALS AND METHODS: This is a cross-sectional survey of patients and providers at an academic medical center...
May 24, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29792442/the-case-against-specialized-visual-spatial-short-term-memory
#12
Candice C Morey
The dominant paradigm for understanding working memory, or the combination of the perceptual, attentional, and mnemonic processes needed for thinking, subdivides short-term memory (STM) according to whether memoranda are encoded in aural-verbal or visual formats. This traditional dissociation has been supported by examples of neuropsychological patients who seem to selectively lack STM for either aural-verbal, visual, or spatial memoranda, and by experimental research using dual-task methods. Though this evidence is the foundation of assumptions of modular STM systems, the case it makes for a specialized visual STM system is surprisingly weak...
May 24, 2018: Psychological Bulletin
https://www.readbyqxmd.com/read/29792334/chemical-constituents-from-dendrobium-hainanense
#13
You-Yuan Zhang, Pei Wang, Xi-Qiang Song, Wen-Jian Zuo, Hao Wang, Liang-Liang Chen, Wen-Li Mei, Hao-Fu Dai
A new phenolic derivative (1) and a new dihydrophenanthrene (2) were isolated from the aerial part of Dendrobium hainanense rofe, along with 12 known compounds. The structures of the new compounds were elucidated by spectroscopic analysis,and the relative configuration of compound 1 was determined by J-based configuration analysis (JBCA) method. Bioassay result indicated that compound 1 exhibited weak antibacterial activity against Canidia albicans and Ralstonia solanaceanum.
May 24, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29792332/ligation-enhanced-%C3%AF-hole%C3%A2-%C3%A2-%C3%A2-%C3%AF-interactions-involving-isocyanides-effect-of-%C3%AF-hole%C3%A2-%C3%A2-%C3%A2-%C3%AF-noncovalent-bonding-on-conformational-stabilization-of-acyclic-diaminocarbene-ligands
#14
Alexander S Mikherdov, Mikhail A Kinzhalov, Alexander S Novikov, Vadim P Boyarskiy, Irina A Boyarskaya, Margarita S Avdontceva, Vadim Yu Kukushkin
The reaction of cis-[PdCl2 (CNXyl)2 ] (Xyl = 2,6-Me2 C6 H3 ) with the aminoazoles [1 H-imidazol-2-amine (1), 4 H-1,2,4-triazol-3-amine (2), 1 H-tetrazol-5-amine (3), 1 H-benzimidazol-2-amine (4), 1-alkyl-1 H-benzimidazol-2-amines, where alkyl = Me (5), Et (6)] in a 2:1 ratio in the presence of a base in CHCl3 at RT proceeds regioselectively and leads to the binuclear diaminocarbene complexes [(ClPdCNXyl)2 {μ-C(N-azolyl)N(Xyl)C═NXyl}] (7-12; 73-91%). Compounds 7-12 were characterized by C, H, N elemental analyses, high-resolution ESI+ -MS, Fourier transform infrared spectroscopy, 1D (1 H, 13 C) and 2D (1 H,1 H-COSY, 1 H,1 H-NOESY, 1 H,13 C-HSQC, 1 H,13 C-HMBC) NMR spectroscopies, and X-ray diffraction (XRDn)...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792325/non-geminal-aliphatic-dihalogenation-pattern-in-dichlorinated-diaporthins-from-hamigera-fusca-nrrl-35721
#15
Celso Almeida, Ignacio Pérez-Victoria, Víctor González-Menéndez, Nuria de Pedro, Jesús Martín, Gloria Crespo, Thomas Mackenzie, Bastien Cautain, Fernando Reyes, Francisca Vicente, Olga Genilloud
Two new epimeric dihalogenated diaporthins, (9 R * )-8-methyl-9,11-dichlorodiaporthin (2) and (9 S * )-8-methyl-9,11-dichlorodiaporthin (3), have been isolated from the soil fungus Hamigera fusca NRRL 35721 alongside the known regioisomeric isocoumarin 8-methyl-11,11-dichlorodiaporthin (1). Their structures were elucidated by high-resolution mass spectrometry and NMR spectroscopy combined with molecular modeling. Compounds 1-3 are the first isocoumarins and the first halogenated metabolites ever reported from the Hamigera genus...
May 24, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29792320/modular-cavities-induced-fit-of-polar-and-apolar-guests-into-halogen-based-receptors
#16
Kentaro Aoki, Kazuya Otsubo, Garry S Hanan, Kunihisa Sugimoto, Hiroshi Kitagawa
Neutral triangular macrocyclic compounds, [PdX2 (4,7-phen)]3 ·(DMF)3 ·Et2 O (X = Cl, Br; 4,7-phen = 4,7-phenanthroline; DMF = N, N'-dimethylformamide; Et2 O = diethyl ether), were synthesized, and their molecular structures were characterized. Solution-state 1 H NMR results suggested the formation of metal-ligand bonds, and single-crystal X-ray crystallography revealed clear triangular structures. A detailed examination of the structures indicated the formation of two kinds of cavities in the solid state, where a triangular unit works as a halogen-based receptor for polar and apolar solvents through weak hydrogen-bonding and dipole-dipole interaction...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792178/anti-ganglioside-complex-antibody-profiles-in-a-recurrent-complicated-case-of-gq1b-seronegative-miller-fisher-syndrome-and-bickerstaff-brainstem-encephalitis-a-case-report
#17
Hiroto Ito, Yuki Hatanaka, Yuki Fukami, Yumiko Harada, Rei Kobayashi, Hisashi Okada, Ayumi Uchibori, Atsuro Chiba, Satoshi Okuda
BACKGROUND: Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE) are a group of autoimmune neurological disorders (GBS spectrum disorder) that rarely recur. Recently, anti-ganglioside complex antibodies (GSC-Abs) were identified in patients with GBS spectrum disorder. However, there has been no case report describing GSC-Abs profiles in a recurrent case showing different phenotypes. CASE PRESENTATION: We report the case of a 33-year-old male patient with GQ1b-seronegative BBE-GBS after two prior episodes of MFS-GBS...
May 23, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29791932/b3galnt2-related-dystroglycanopathy-expansion-of-the-phenotype-with-novel-mutation-associated-with-muscle-eye-brain-disease-walker-warburg-syndrome-epileptic-encephalopathy-west-syndrome-and-sensorineural-hearing-loss
#18
Muna A Al Dhaibani, Ayman W El-Hattab, Omar Ismayl, Jehan Suleiman
Mutations in B3GALNT2 , encoding a glycosyltransferase enzyme involved in α-dystroglycan glycosylation, have been recently associated with dystroglycanopathy, a well-recognized subtype of congenital muscular dystrophy (CMD). Only a few cases have been reported with B3GALNT2 -related dystroglycanopathy with variable severity ranging from mild CMD to severe muscle-eye-brain disease. Here, we describe a child with a novel homozygous nonsense mutation in B3GALNT2 . The affected child has severe neurological disease since birth, including muscle disease manifested as hypotonia, muscle weakness, and wasting with elevated creatine kinase, eye disease including microphthalmia and blindness, brain disease with extensive brain malformations including massive hydrocephalus, diffuse cobblestone-lissencephaly, deformed craniocervical junction, and pontocerebellar hypoplasia...
May 23, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29791860/the-olfactory-logic-behind-fruit-odor-preferences-in-larval-and-adult-drosophila
#19
Hany K M Dweck, Shimaa A M Ebrahim, Tom Retzke, Veit Grabe, Jerrit Weißflog, Ales Svatoš, Bill S Hansson, Markus Knaden
Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors differs from that of adult flies. Next, we provide a functional analysis of the full repertoire of the peripheral olfactory system using the same comprehensive stimulus spectrum. We find that 90% and 53% of larval and adult olfactory receptors tested here, respectively, are involved in evaluating these fruit odors...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791626/aging-and-quality-of-life-of-elderly-people-in-rural-areas
#20
Juliana Ladeira Garbaccio, Luís Antônio Batista Tonaco, Wilson Goulart Estêvão, Bárbara Jacome Barcelos
OBJECTIVE: To evaluate the quality of life and health of elderly in rural areas of Minas Gerais State's center-west. METHOD: Cross-sectional study, in four municipalities of Minas Gerais State, by interviewing elderly people. Associations between socio-demographic and quality of life variables were tested, separated into "satisfactory"/"unsatisfactory" with values from the median of positive answers. It was used the chi-square test, Fisher's test and regression...
2018: Revista Brasileira de Enfermagem
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