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https://www.readbyqxmd.com/read/28738646/synthesis-characterization-and-application-of-a-novel-multifunctional-stationary-phase-for-hydrophilic-interaction-reversed-phase-mixed-mode-chromatography
#1
Hayriye Aral, K Serdar Çelik, Ramazan Altındağ, Tarık Aral
A novel multifunctional stationary phase based on silica gel was synthesised starting from L- isoleucine and 4-phenylbutylamine and evaluated as a hydrophilic interaction/reversed-phase mixed-mode stationary phase for high-performance liquid chromatography (HPLC). The prepared stationary phase was characterized by elemental analysis, infrared spectroscopy (IR), scanning electron microscopy (SEM), Brunauer, Emmett and Teller (BET) and solid-state (13)C nuclear magnetic resonance (NMR). The mechanisms involved in the chromatographic separation are multi-interaction, including hydrophobic, π-π, hydrogen-bonding, dipole-dipole and ion-dipole interactions...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738568/novel-imidazole-fluorescent-poly-ionic-liquid-nanoparticles-for-selective-and-sensitive-determination-of-pyrogallol
#2
Zhouyang Li, Yiwen Yang, Yanbo Zeng, Jianbo Wang, Haiqing Liu, Longhua Guo, Lei Li
This paper reports novel imidazole fluorescent poly(ionic liquid) nanoparticles (FPILNs) of poly(1-[(4-methyphenyl)methyl]-3-vinyl-imidazolium bromide (poly([MVI]Br) for selective and sensitive determination of pyrogallol. An imidazole ionic liquid of 1-[(4-methyphenyl)methyl]-3-vinyl-imidazolium bromide ([MVI]Br) was synthesized and used as the only monomer to obtain poly([MVI]Br) possessing phenyl fluorophores using a radical polymerization technique. The obtained poly([MVI]Br) can form nanoparticles in water...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738443/urethral-injection-therapy-for-urinary-incontinence-in-women
#3
REVIEW
Vivienne Kirchin, Tobias Page, Phil E Keegan, Kofi Om Atiemo, June D Cody, Samuel McClinton, Patricia Aluko
BACKGROUND: Urinary incontinence imposes a significant health and economic burden to society. Periurethral or transurethral injection of bulking agents is a minimally invasive surgical procedure used as one the surgical treatments of stress urinary incontinence (SUI) in adult women. OBJECTIVES: To assess the effects of periurethral or transurethral injection therapy on the cure or improvement of urinary incontinence in women. SEARCH METHODS: We searched the Cochrane Incontinence Group Specialised Trials Register (searched 8 November 2010) and the reference lists of relevant articles...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28738384/sweet-taste-perception-and-dental-caries-in-13-to-15-year-olds-a-multicenter-cross-sectional-study
#4
H Ashi, C Lara-Capi, G Campus, G Klingberg, P Lingström
Dietary habits and, in particular, the intake frequency of sucrose are of major importance for the development of dental caries. The perception of sweet taste is believed to have an influence on sucrose intake and therefore affects the predisposition to dental caries. The aim was to study the caries experience and sweet taste perception and to further analyze the possible relationship between the 2 tested variables in 13- to 15-year-old children from 3 different geographical areas. A cross-sectional survey comprising 669 children (220 Italian, 224 Mexican, and 225 Saudi Arabian) was conducted...
July 25, 2017: Caries Research
https://www.readbyqxmd.com/read/28738317/the-application-of-signalling-theory-to-health-related-trust-problems-the-example-of-herbal-clinics-in-ghana-and-tanzania
#5
Kate Hampshire, Heather Hamill, Simon Mariwah, Joseph Mwanga, Daniel Amoako-Sakyi
In contexts where healthcare regulation is weak and levels of uncertainty high, how do patients decide whom and what to trust? In this paper, we explore the potential for using Signalling Theory (ST, a form of Behavioural Game Theory) to investigate health-related trust problems under conditions of uncertainty, using the empirical example of 'herbal clinics' in Ghana and Tanzania. Qualitative, ethnographic fieldwork was conducted over an eight-month period (2015-2016) in eight herbal clinics in Ghana and ten in Tanzania, including semi-structured interviews with herbalists (N = 18) and patients (N = 68), plus detailed ethnographic observations and twenty additional key informant interviews...
July 15, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28738206/a-preliminary-study-on-the-effects-of-lanthanum-iii-on-plant-vitronectin-like-protein-and-its-toxicological-basis
#6
Lihong Wang, Jingfang He, Qing Yang, Xiaodong Li, Haiyan Wei, David D Y Chen, Xiaohua Huang
Vitronectin-like protein (VN) is widely found outside plant plasma membranes. The VN molecular surface contains a large number of active groups that combine strongly with rare earth elements (REEs), which means that VN is a preferential binding target for REEs exhibiting their toxic effects, but the toxicological mechanism remains unknown. This study used transmission electron microscopy, circular dichroism, fluorescence spectrometry, ultraviolet-visible spectroscopy, X-ray photoelectron spectroscopy, and calculational chemistry (homology modeling, molecular dynamics simulation and quantum chemical calculation) to preliminarily investigate the effect of lanthanum [La(III)] as an REE, on the structure of VN and its toxicological mechanism...
July 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28738126/comparing-plasma-phospho-tau-total-tau-and-phospho-tau-total-tau-ratio-as-acute-and-chronic-traumatic-brain-injury-biomarkers
#7
Richard Rubenstein, Binggong Chang, John K Yue, Allen Chiu, Ethan A Winkler, Ava M Puccio, Ramon Diaz-Arrastia, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, Wayne A Gordon, David O Okonkwo, Peter Davies, Sanjeev Agarwal, Fan Lin, George Sarkis, Hamad Yadikar, Zhihui Yang, Geoffrey T Manley, Kevin K W Wang, Shelly R Cooper, Kristen Dams-O'Connor, Allison J Borrasso, Tomoo Inoue, Andrew I R Maas, David K Menon, David M Schnyer, Mary J Vassar
Importance: Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. Objective: To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI...
July 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28738107/acupuncture-in-temporomandibular-disorder-myofascial-pain-treatment-a-systematic-review
#8
Ana Carla Fernandes, Dayanne Monielle Duarte Moura, Laura Géssica Dantas Da Silva, Erika Oliveira De Almeida, Gustavo Augusto Seabra Barbosa
AIMS: To carry out a systematic review of clinical trials published up to 2015 to determine the effectiveness of acupuncture in treating myofascial pain in temporomandibular disorder (TMD) patients. METHODS: The databases used were the Cochrane Library, PubMed, Scopus, and Web of Science; the dates of the articles surveyed ranged from 1990 to May 2015. The inclusion criteria were: (1) publications in English, Portuguese, or Spanish; (2) controlled clinical trials; (3) patients with TMD of muscular origin; and (4) studies that used acupuncture or laser acupuncture only for treatment...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28738092/the-efficacy-of-jianpi-yiqi-therapy-for-chronic-atrophic-gastritis-a-systematic-review-and-meta-analysis
#9
Yun-Kai Dai, Yun-Zhan Zhang, Dan-Yan Li, Jin-Tong Ye, Ling-Feng Zeng, Qi Wang, Ling Hu
Jianpi Yiqi therapy (JYT) is a classical therapy in treating chronic atrophic gastritis (CAG), but the clinical effects of it are still contentious. The purpose of this article is to evaluate the efficacy and safety of JYT for CAG. Seven electronic databases including PubMed, Embase, Springer Link, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database), Wan-fang database, and CBM (Chinese Biomedicine Database) were searched from their inception to November 1, 2016. 13 randomized controlled trials (RCTs) with a total of 1119 participants were identified for analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28738015/observational-study-to-estimate-the-changes-in-the-effectiveness-of-bacillus-calmette-gu%C3%A3-rin-bcg-vaccination-with-time-since-vaccination-for-preventing-tuberculosis-in-the-uk
#10
Punam Mangtani, Patrick Nguipdop-Djomo, Ruth H Keogh, Lucy Trinder, Peter G Smith, Paul Em Fine, Jonathan Sterne, Ibrahim Abubakar, Emilia Vynnycky, John Watson, David Elliman, Marc Lipman, Laura C Rodrigues
BACKGROUND: Until recently, evidence that protection from the bacillus Calmette-Guérin (BCG) vaccination lasted beyond 10 years was limited. In the past few years, studies in Brazil and the USA (in Native Americans) have suggested that protection from BCG vaccination against tuberculosis (TB) in childhood can last for several decades. The UK's universal school-age BCG vaccination programme was stopped in 2005 and the programme of selective vaccination of high-risk (usually ethnic minority) infants was enhanced...
July 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28738014/enhancer-of-zeste-homologue-2-ezh2-expression-in-synovial-sarcomas-as-a-promising-indicator-of-prognosis
#11
Ulviye Yalçınkaya, Nesrin Uğraş, Gonca Özgün, Gökhan Ocakoğlu, Adem Deligönül, Sibel Kahraman Çetintaş, Muhammed Sadık Bilgen
Synovial sarcoma (SS) is a type of soft tissue sarcoma, often linked to poor survival. Although overexpression of enhancer of zeste homologue 2 (EZH2) has been associated with poor prognosis in different tumors, a few studies investigated this link in SS. Here, we analyzed the relationship between EZH2 expression and prognostic factors in SS. We included 29 patients with SS. Immunostaining of EZH2 was performed with (D2C9) XPTM Rabbit mAb antibody, and the results were classified as low EZH2 expression (negative or weak expression) and high EZH2 expression category (moderate or strong expression)...
July 24, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28737940/defining-the-structural-basis-for-allosteric-product-release-from-e-coli-dihydrofolate-reductase-using-nmr-relaxation-dispersion
#12
David Oyen, R Bryn Fenwick, Phillip C Aoto, Robyn L Stanfield, Ian A Wilson, H Jane Dyson, Peter E Wright
The rate-determining step in the catalytic cycle of E.coli dihydrofolate reductase is tetrahydrofolate (THF) product release, which can occur via an allosteric or an intrinsic pathway. The allosteric pathway, which becomes accessible when the reduced cofactor NADPH is bound, involves transient sampling of a higher energy conformational state, greatly increasing the product dissociation rate compared to the intrinsic pathway that obtains when NADPH is absent. Although the kinetics of this process are known, the enzyme structure and the THF product conformation in the transiently formed excited state remains elusive...
July 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28737937/asymmetric-hydrogen-bonding-catalysis-for-the-synthesis-of-dihydroquinazoline-containing-antiviral-letermovir
#13
Cheol K Chung, Zhijian Liu, Katrina Lexa, Teresa Andreani, Yingju Xu, Yining Ji, Daniel Adam DiRocco, Guy R Humphrey, Rebecca Tamra Ruck
A weak Brønsted acid-catalyzed asymmetric guanidine aza-conjugate addition reaction has been developed. C2-symmetric, dual hydrogen-bond donating bistriflamides are shown to be highly effective in activating α,β-unsaturated esters toward the intramolecular addition of a pendant guanidinyl nucleophile. Preliminary mechanistic investigation, including DFT calculations and kinetics studies, support a conjugate addition pathway as more favorable energetically than an alternative electrocyclization pathway. This methodology has been successfully applied to the synthesis of the 3,4-dihydroquinazoline-containing antiviral, Letermovir, and a series of analogues...
July 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28737935/the-current-state-of-peptide-drug-discovery-back-to-the-future
#14
Antoine Henninot, James C Collins, John M Nuss
Over the last decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs, and how this class of compounds can be an excellent complement or even preferable alternative to small molecule and biological therapeutics. In this perspective we give a concise description of the recent progress in peptide drug discovery in a holistic manner, highlighting enabling technological advances affecting nearly every aspect of this field: from lead discovery, to synthesis and optimization, to peptide drug delivery...
July 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28737917/antagonistic-interplay-between-an-intermolecular-ch%C3%A2-%C3%A2-%C3%A2-o-and-an-intramolecular-oh%C3%A2-%C3%A2-%C3%A2-o-hydrogen-bond-in-a-1-1-complex-between-1-2-cyclohexanedione-and-chloroform-a-combined-matrix-isolation-infrared-and-quantum-chemistry-study
#15
Amit Kumar Samanta, Pujarini Banerjee, Biman Bandyopadhyay, Prasenjit Pandey, Tapas Chakraborty
Matrix isolation infrared spectra of a weak C-H•••O hydrogen bonded complex between the keto-enol form of 1,2-cyclohexanedione (HCHD) and chloroform have been measured. The spectra reveal that the intramolecular O-H•••O H-bond of HCHD is weakened as a result of complex formation, manifesting in prominent blue shift (~23 cm-1) of the νO-H band and red shifts (~7 cm-1) of νC=O bands of the acceptor (HCHD). The νC-H band of donor CHCl3 undergoes a large red shift of ~33 cm-1. Very similar spectral effects are also observed for formation of the complex in CCl4 solution at room temperature...
July 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28737865/unusual-increase-of-cases-of-myelitis-in-a-pediatric-hospital-in-argentina
#16
Guadalupe Pérez, María T Rosanova, María C Freire, María I Paz, Silvina Ruvinsky, Carlos Rugilo, Víctor Ruggieri, Daniel Cisterna, Soledad Martiren, Cristina Lema, Andrea Savransky, Soledad González, Leila Martínez, Diana Viale, Rosa Bologna
INTRODUCTION: The association between enterovirus D68 and acute flaccid myelitis was first described in the United States in 2014. Since then, sporadic cases have been reported in Canada and Europe. This study describes a series of cases of acute flaccid myelitis at Hospital de Pediatría "Prof. Dr. Juan P. Garrahan," in Buenos Aires, Argentina, during 2016. METHODS: Descriptive, retrospective study. All patients with acute flaccid myelitis and lesions in the spinal cord involving the gray matter, as observed in the magnetic resonance imaging (MRI) scan, hospitalized from 04/01/2016 to 07/01/2016, were included in the study...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737787/coming-full-circle-constructing-a-gd6-wheel-dimer-by-dimer-and-the-importance-of-spin-topology
#17
Thomas N Hooper, Stuart K Langley, Silvia Gómez-Coca, Giulia Lorusso, Eliseo Ruiz, Keith S Murray, Marco Evangelisti, Euan K Brechin
The syntheses, structures, magnetic and thermodynamic properties of three related triethanolamine-based Gd(III) complexes are described. The smallest, a dimer ([Gd2]), can be viewed as the subunit from which the two larger complexes, a linear tetramer ([Gd2]2) and a cyclic hexamer ([Gd2]3), are composed by further deprotonation of the triethanolamine ligand. In all cases, nearest neighbour magnetic ions are weakly correlated by antiferromagnetic isotropic exchange, whose strength does not change significantly from one complex to another; J ranging from -0...
July 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28737780/ultra-low-lattice-thermal-conductivity-and-high-carrier-mobility-of-monolayer-sns2-and-snse2-a-first-principles-study
#18
Aamir Shafique, Abdus Samad, Young-Han Shin
Using density functional theory, we systematically investigate the lattice thermal conductivity and carrier mobility of monolayer SnX2 (X = S, Se). The room-temperature ultra low lattice thermal conductivities found in monolayer SnS2 (6.41 W m(-1) K(-1)) and SnSe2 (3.82 W m(-1) K(-1)) are attributed to the low phonon velocity, low Debye temperature, weak bonding interactions, and strong anharmonicity in monolayer SnX2. The predicted values of lattice thermal conductivity are lower than those of other two-dimensional materials such as stanene, phosphorene, monolayer MoS2, and bulk SnX2...
July 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28737354/-do-electronic-cigarettes-increase-the-risk-of-smoking-among-adolescents-and-young-adults
#19
Sylvain Gautier, Shérazade Kinouani, Chantal Raherison
Introduction: Electronic cigarette use is significantly higher among 15-24-year-olds than in other age-groups. Electronic cigarettes, which may contain nicotine, could be a gateway to smoking initiation among young people. In this article, we reviewed the literature on smoking initiation or smoking enhancement by the use of e-cigarettes. Methods: We carried out a qualitative analysis in January 2016. We selected all longitudinal studies among adolescents or young adults using electronic cigarettes. Results: The analysis focused on 5 of the 544 articles identified, corresponding to five prospective observational studies...
July 10, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28737196/-results-of-a-national-program-of-pediatric-heart-transplantation-strengths-and-weakness
#20
Pedro Becker, Santiago Besa, Sergio Riveros, Rodrigo González, Alfonso Navia, Paulina Dellepiane, Daniel Springmuller, Gonzalo Urcelay
Pediatric heart transplantation is an effective therapy to treat advanced heart failure in children. OBJECTIVES: To analyze the immediate and mid-term results of pediatric patients listed for heart transplantation. PATIENTS AND METHODS: Registration of patients admitted to our transplant protocol between October 2001 and July 2016 were reviewed, analyzing demographic data, diagnosis, status at the time of listing, waiting time until transplantation, donor data, use of ventricular assist device, hemodynamic data, complications and global mortality...
June 2017: Revista Chilena de Pediatría
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