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university of washington

Nora E Fritz, Nicholas R Boileau, Julie C Stout, Rebecca Ready, Joel S Perlmutter, Jane S Paulsen, Kimberly Quaid, Stacey Barton, Michael K McCormack, Susan L Perlman, Noelle E Carlozzi
Up to 90% of individuals with Huntington's disease (HD)-a progressive, inherited neurodegenerative disorder-experience apathy. Apathy is particularly debilitating because it is marked by a reduction in goal-directed behaviors, including self-care, social interactions, and mobility. The objective of this study was to examine relationships between variables of apathy, functional status, physical function, cognitive function, behavioral status/emotional function, and health-related quality of life. Clinician-rated measures of physical, cognitive, and behavioral function, including one clinician-rated item on apathy, and self-reported measures of physical function, health-related quality of life, and emotional, cognitive, and social function were collected in a single session from 487 persons with the HD mutation (prodromal, N=193; early-stage manifest, N=186; late-stage manifest, N=108)...
March 21, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
(no author information available yet)
Stachler RJ, Francis DO, Schwartz SR, et al. Clinical practice guideline: hoarseness (dysphonia) (update). Otolaryngol Head Neck Surg. 2018;158:S1-S42. (Original DOI: 10.1177/0194599817751030) Stachler RJ, Francis DO, Schwartz SR, et al. Clinical practice guideline: hoarseness (dysphonia) (update) executive summary. Otolaryngol Head Neck Surg. 2018;158:409-426. (Original DOI: 10.1177/0194599817751031) Krouse HJ, Reavis CW, Stachler RJ, Francis DO, O'Connor S. Plain language summary: hoarseness (dysphonia). Otolaryngol Head Neck Surg...
March 1, 2018: Otolaryngology—Head and Neck Surgery
Alvaro Sanabria, Daniel Sánchez, Andrés Chala, Andres Alvarez
The effect on quality of life (QOL) of laryngectomy and organ preservation protocols is important in decision making. The aim of this cross-sectional study was to evaluate QOL outcomes of patients with advanced laryngeal tumors who were treated with laryngectomy or organ preservation protocols in Latin America. A total of 35 patients from three oncology units were enrolled. Patients with stage III/IV laryngeal cancer who were treated using organ preservation protocols or laryngectomy were assessed with the University of Washington QOL Questionnaire...
March 2018: Ear, Nose, & Throat Journal
Mary Bates
The opioid epidemic is dominating news headlines and inspiring greater calls for political action in the United States. While opioid addiction isn't a new issue, its devastating consequences are now being felt across the country. "What's got everybody's attention is that so many people are dying," says Dr. Richard Ries (Figure 1), director of the University of Washington School of Medicine?s addictions divisions and medical director of the Outpatient Addictions Program at Harborview Medical Center, Seattle...
March 2018: IEEE Pulse
Ron J Smith
BACKGROUND: Siege, a process of political domination aimed at isolating an entire population, is a unique threat to health-care provision. The aim of this study was to qualitatively examine the effects of the Israeli siege on the practices and systems that underlie health in the Gaza Strip. METHODS: Data were from participant observation between 2009 and 2017, including 20 interviews with doctors and health administrators in non-governmental organisations (NGO), government, and UN sectors...
February 21, 2018: Lancet
Amrita Aranake-Chrisinger, Jenny Zhao Cheng, Maxwell R Muench, Rose Tang, Angela Mickle, Hannah Maybrier, Nan Lin, Troy Wildes, Eric Lenze, Michael Simon Avidan
INTRODUCTION: Postoperative delirium (POD) is a common complication in elderly patients, characterised by a fluctuating course of altered consciousness, disordered thinking and inattention. Preliminary research has linked POD with persistent cognitive impairment and decreased quality of life. However, these findings maybe confounded by patient comorbidities, postoperative complications and frailty. Our objective is to determine whether POD is an independent risk factor for persistent impairments in attention and executive function after elective surgery...
March 17, 2018: BMJ Open
Nick Jikomes, Michael Zoorob
The majority of adults in the U.S. now have state-legal access to medical or recreational cannabis products, despite their federal prohibition. Given the wide array of pharmacologically active compounds in these products, it is essential that their biochemical profile is measured and reported to consumers, which requires accurate laboratory testing. However, no universal standards for laboratory testing protocols currently exist, and there is controversy as to whether all reported results are legitimate. To investigate these concerns, we analyzed a publicly available seed-to-sale traceability dataset from Washington state containing measurements of the cannabinoid content of legal cannabis products from state-certified laboratories...
March 14, 2018: Scientific Reports
Saira Khan, Veronica Hicks, Danielle Rancilio, Marvin Langston, Katina Richardson, Bettina F Drake
Long-term follow-up care among prostate cancer patients is important as biochemical recurrence can occur many years after diagnosis, with 20%-30% of men experiencing biochemical recurrence within 10 years of treatment. This study examined predictors of follow-up care among 1,158 radical prostatectomy patients, treated at the Washington University in St. Louis, within 6 months, 1 year, and 2 years post surgery. Predictors examined included age at surgery, race (Black vs. White), rural/urban status, education, marital status, and prostate cancer aggressiveness...
March 1, 2018: American Journal of Men's Health
Solina Tith, Garinder Bining, Laurent Bollag
Background : Opioid use during pregnancy is a growing concern in the United States. Buprenorphine has been recommended by "The American College of Obstetrics and Gynecology" as an alternative to methadone to decrease risks associated with the use of illicit opioids during pregnancy. The partial μ-opioid agonists' unique pharmacology, including its long half time and high affinity to the μ-opioid receptor, complicates patient management in a highly kinetic, and often urgent field like obstetric anesthesia...
2018: F1000Research
Eline A J Willemse, Ann De Vos, Elizabeth M Herries, Ulf Andreasson, Sebastiaan Engelborghs, Wiesje M van der Flier, Philip Scheltens, Dan Crimmins, Jack H Ladenson, Eugeen Vanmechelen, Henrik Zetterberg, Anne M Fagan, Kaj Blennow, Maria Bjerke, Charlotte E Teunissen
BACKGROUND: Neurogranin in cerebrospinal fluid (CSF) correlates with cognitive decline and is a potential novel biomarker for Alzheimer disease (AD) dementia. We investigated the analytical and diagnostic performance of 3 commonly used neurogranin assays in the same cohort of patients to improve the interpretability of CSF neurogranin test results. METHODS: The neurogranin Singulex assay from Washington University, St. Louis, MO (WashU); ELISA from ADx Neurosciences; and ELISA from Gothenburg University, Mölndal, Sweden (UGot), were compared using silver staining and Western blot after gel electrophoresis...
March 9, 2018: Clinical Chemistry
Ryan C Shean, Alexander L Greninger
Infectious pathogens are known for their rapid evolutionary rates with new mutations arising over days to weeks. The ability to rapidly recover whole genome sequences and analyze the spread and evolution of pathogens using genetic information and pathogen collection dates has lead to interest in real-time tracking of infectious transmission and outbreaks. However, the level of temporal resolution afforded by these analyses may conflict with definitions of what constitutes protected health information (PHI) and privacy requirements for de-identification for publication and public sharing of research data and metadata...
January 2018: Virus Evolution
Ann H Kim, Gener Augustin, Andrew Shevitz, Hannah Kim, Michael R Trivonovich, Alexis R Powell, Norman Kumins, Robert Tarr, Vikram S Kashyap
The decision to intervene for internal carotid stenosis often depends on the degree of stenosis seen on duplex ultrasound (US). The aim of this study is to compare the diagnostic accuracy of two criteria: modified University of Washington (UW) and 2003 Carotid Consensus Panel (CCP). All patients undergoing US in an accredited (IAC) vascular laboratory from January 2010 to June 2015 were reviewed ( n=18,772 US exams). Patients receiving a neck computed tomography angiography (CTA) within 6 months of the US were included in the study ( n=254)...
March 1, 2018: Vascular Medicine
Aliya Alimujiang, Kellie R Imm, Catherine M Appleton, Graham A Colditz, Catherine S Berkey, Adetunji T Toriola
Although childhood adiposity is inversely associated with breast cancer risk, the association of childhood adiposity with mammographic density in premenopausal women has not been adequately studied. We analyzed data from 365 premenopausal women who came in for screening mammography at Washington University in St. Louis from 2015 to 2016. Body size at age 10 was self-reported using Somatotype pictogram. Body mass index (BMI) at age 10 was imputed using data from Growing Up Today Study. Volpara software was used to evaluate volumetric percent density (VPD), dense volume (DV) and non-dense volume (NDV)...
March 2, 2018: Cancer Prevention Research
Howard Casey Cromwell
Presents an obituary for Jaak Panksepp, who died April 18, 2017. Panksepp reshaped the landscape of psychology by highlighting emotions and coincident feelings in basic and clinical research. Most of his career was spent convincing others that the key to understanding human mental illness was the understanding of primal emotional operating systems in conserved neural circuitry. His framework was carefully laid out in his book Affective Neuroscience: The Foundation of Human and Animal Emotions (1998). His controversial writings vigorously pushed for the acceptance of nonhuman animal feelings as primary states that link to motivated action and emotional expression...
February 2018: American Psychologist
Terence Mitchell
Presents an obituary for Fred Edward Fiedler, who died June 8, 2017. Fiedler made four truly significant contributions to the field of psychology. First, he changed the way psychologists think about successful leadership. His book A Theory of Leadership Effectiveness (1967) provided the foundation for much of his later work. Second, at both the University of Illinois and the University of Washington, Fiedler had his own research building and facility. Third, he had an outstanding reputation. He was known around the world for his writing, lectures, and consulting work...
February 2018: American Psychologist
Jorge L Del-Aguila, Maria Victoria Fernández, Suzanne Schindler, Laura Ibanez, Yuetiva Deming, Shengmei Ma, Ben Saef, Kathleen Black, John Budde, Joanne Norton, Rachel Chasse, Oscar Harari, Alison Goate, Chengjie Xiong, John C Morris, Carlos Cruchaga
Many genetic studies for Alzheimer's disease (AD) have been focused on the identification of common genetic variants associated with AD risk and not on other aspects of the disease, such as age at onset or rate of dementia progression. There are multiple approaches to untangling the genetic architecture of these phenotypes. We hypothesized that the genetic architecture of rate of progression is different than the risk for developing AD dementia. To test this hypothesis, we used longitudinal clinical data from ADNI and the Knight-ADRC at Washington University, and we calculated PRS (polygenic risk score) based on the IGAP study to compare the genetic architecture of AD risk and dementia progression...
2018: Journal of Alzheimer's Disease: JAD
Michael F Fialkow, Carrie M Snead, Jay Schulkin
Introduction: As the US health-care system has evolved over the past decade, access to obstetric care in rural communities has declined, and there has been a challenge in retaining obstetrics and gynecology (OB-GYN) providers to train the next generation of physicians. The current pilot study sought to identify the factors that influence faculty who train medical students within the field of OB-GYN with the hope of influencing recruitment and retention of providers for the future. Methods: Clinical OB-GYN faculty within the University of Washington School of Medicine regional medical education program were surveyed about practice patterns and beliefs regarding medical student training as part of a pilot study on provider recruitment and retention...
January 2018: Health Services Research and Managerial Epidemiology
Christoph Becker, Jens Pfeiffer, Kitty Lange, Kilian Konrad Kenjiro Dahlem
PURPOSE: To evaluate the health-related quality of life (QOL) in patients with major salivary gland carcinoma (MSGC). METHODS: 45 patients with MSGC completed the University of Washington Quality of Life (UWQOL) questionnaire. Results and factors influencing quality of life were analyzed using Mann-Whitney U test. RESULTS: 24 patients were male, 21 patients were female, and median age was 57 years. 33 patients presented with early stage (UICC stage I or II) cancer...
April 2018: European Archives of Oto-rhino-laryngology
P Sakthivel, D V K Irugu, C A Singh, H Verma, R Yogal, B Jat, A Chadran, K Sikka, A Thakar, S C Sharma
CONTEXT: To evaluate the quality of life (QOL) outcome measures in disease-free survivors of pathological T1/T2 tongue cancers and to compare QOL in patients treated with only surgery and with adjuvant treatment. SETTINGS AND DESIGN: Cross-sectional survey. PATIENTS AND METHODS: All pathological T1/T2 anterior tongue cancer cases with follow-up from January 2011 till December 2015, who had locoregionally controlled disease with a minimum disease-free survival period of 1 year, were included in the study...
April 2017: Indian Journal of Cancer
Stacia Crochet, Chun-Chih Huang, Melissa Fries, Rachel K Scott
Background: A case of mother to child transmission (MTCT) of HIV at a medical center in Washington, DC, resulted in the implementation of universal opt-out rapid testing of patients admitted for delivery. This article evaluates the policy's efficacy and implementation. Methods: We evaluated the implementation using the Reach, Efficacy, Adoption, Implementation, and Maintenance (RE-AIM) framework. Results: We could not evaluate decrease in MTCT rate secondary to low sample size ( n  = 3324) and no true-positive results...
March 2018: Therapeutic Advances in Infectious Disease
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