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https://www.readbyqxmd.com/read/29766817/characteristics-and-outcomes-of-patients-with-anti-glomerular-basement-membrane-antibody-disease-and-anti-neutrophil-cytoplasmic-antibodies
#1
Percy Balderia, Nicole Andeen, Jonathan Ashley Jefferson
BACKGROUND: It is unclear whether patients with anti-glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCA), so called "double-positive" (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone...
May 16, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29756480/tracheoesophageal-prosthesis-use-is-associated-with-improved-overall-quality-of-life-in-veterans-with-laryngeal-cancer
#2
Ramya S Patel, Tiffany Mohr, Christine Hartman, Carol Stach, Andrew G Sikora, Jose P Zevallos, Vlad C Sandulache
OBJECTIVES: Veterans have an increased risk of laryngeal cancer, yet their oncologic and functional outcomes remain understudied. We sought to determine the longitudinal impact of tracheoesophageal puncture and voice prosthesis on quality-of-life measures in veterans following total laryngectomy (TL). METHODS: We performed a cross-sectional analysis of TL patients (n = 68) treated at the Michael E. DeBakey Veterans Affairs Medical Center using the Voice Handicap Index (VHI), MD Anderson Dysphagia Index (MDADI), and University of Washington Quality of Life Index (UW-QOL)...
May 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29740479/a-new-single-nucleotide-polymorphism-database-for-rainbow-trout-generated-through-whole-genome-resequencing
#3
Guangtu Gao, Torfinn Nome, Devon E Pearse, Thomas Moen, Kerry A Naish, Gary H Thorgaard, Sigbjørn Lien, Yniv Palti
Single-nucleotide polymorphisms (SNPs) are highly abundant markers, which are broadly distributed in animal genomes. For rainbow trout ( Oncorhynchus mykiss ), SNP discovery has been previously done through sequencing of restriction-site associated DNA (RAD) libraries, reduced representation libraries (RRL) and RNA sequencing. Recently we have performed high coverage whole genome resequencing with 61 unrelated samples, representing a wide range of rainbow trout and steelhead populations, with 49 new samples added to 12 aquaculture samples from AquaGen (Norway) that we previously used for SNP discovery...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29710329/chronic-meningitis-investigated-via-metagenomic-next-generation-sequencing
#4
Michael R Wilson, Brian D O'Donovan, Jeffrey M Gelfand, Hannah A Sample, Felicia C Chow, John P Betjemann, Maulik P Shah, Megan B Richie, Mark P Gorman, Rula A Hajj-Ali, Leonard H Calabrese, Kelsey C Zorn, Eric D Chow, John E Greenlee, Jonathan H Blum, Gary Green, Lillian M Khan, Debarko Banerji, Charles Langelier, Chloe Bryson-Cahn, Whitney Harrington, Jairam R Lingappa, Niraj M Shanbhag, Ari J Green, Bruce J Brew, Ariane Soldatos, Luke Strnad, Sarah B Doernberg, Cheryl A Jay, Vanja Douglas, S Andrew Josephson, Joseph L DeRisi
Importance: Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhanced, unbiased diagnostic approaches are needed. Objective: To present a case series of patients with diagnostically challenging subacute or chronic meningitis using metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) supported by a statistical framework generated from mNGS of control samples from the environment and from patients who were noninfectious...
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29705031/-3-he-diffusion-mri-in-human-lungs
#5
Jason C Woods, Mark S Conradi
Hyperpolarized 3 He gas allows the air spaces of the lungs to be imaged via MRI. Imaging of restricted diffusion is addressed here, which allows the microstructure of the lung to be characterized through the physical restrictions to gas diffusion presented by airway and alveolar walls in the lung. Measurements of the apparent diffusion coefficient (ADC) of 3 He at time scales of milliseconds and seconds are compared; measurement of acinar airway sizes by determination of the microscopic anisotropy of diffusion is discussed...
April 25, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29689197/ari-1-regulates-myonuclear-organization-together-with-parkin-and-is-associated-with-aortic-aneurysms
#6
Kai Li Tan, Nele A Haelterman, Callie S Kwartler, Ellen S Regalado, Pei-Tseng Lee, Sonal Nagarkar-Jaiswal, Dong-Chuan Guo, Lita Duraine, Michael F Wangler, Michael J Bamshad, Deborah A Nickerson, Guang Lin, Dianna M Milewicz, Hugo J Bellen
Nuclei are actively positioned and anchored to the cytoskeleton via the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. We identified mutations in the Parkin-like E3 ubiquitin ligase Ariadne-1 (Ari-1) that affect the localization and distribution of LINC complex members in Drosophila. ari-1 mutants exhibit nuclear clustering and morphology defects in larval muscles. We show that Ari-1 mono-ubiquitinates the core LINC complex member Koi. Surprisingly, we discovered functional redundancy between Parkin and Ari-1: increasing Parkin expression rescues ari-1 mutant phenotypes and vice versa...
April 23, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29672676/a-trial-of-a-single-tablet-regimen-of-elvitegravir-cobicistat-emtricitabine-and-tenofovir-disoproxil-fumarate-for-the-initial-treatment-of-hiv-2-infection-in-a-resource-limited-setting-48-week-results-from-senegal-west-africa
#7
Selly Ba, Dana N Raugi, Robert A Smith, Fatima Sall, Khadim Faye, Stephen E Hawes, Papa Salif Sow, Moussa Seydi, Geoffrey S Gottlieb
Background: There is an urgent need for safe and effective ART for HIV-2 infection. We undertook the first clinical trial of a single-tablet-regimen containing elvitegravir-cobicistat-emtricitabine-tenofovir disoproxil fumarate (E/C/F/TDF) to assess its effectiveness in HIV-2-infected individuals in Senegal, West Africa. Methods: HIV-2-infected, ART-naïve adults with WHO stage 3-4 disease or CD4 counts below 750 cells/mm3 were eligible for this 48 week, open-label trial...
April 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29671837/analysis-of-17-genes-detects-mutations-in-81-of-811-patients-with-lissencephaly
#8
Nataliya Di Donato, Andrew E Timms, Kimberly A Aldinger, Ghayda M Mirzaa, James T Bennett, Sarah Collins, Carissa Olds, Davide Mei, Sara Chiari, Gemma Carvill, Candace T Myers, Jean-Baptiste Rivière, Maha S Zaki, Joseph G Gleeson, Andreas Rump, Valerio Conti, Elena Parrini, M Elizabeth Ross, David H Ledbetter, Renzo Guerrini, William B Dobyns
PurposeTo estimate diagnostic yield and genotype-phenotype correlations in a cohort of 811 patients with lissencephaly or subcortical band heterotopia.MethodsWe collected DNA from 756 children with lissencephaly over 30 years. Many were tested for deletion 17p13.3 and mutations of LIS1, DCX, and ARX, but few other genes. Among those tested, 216 remained unsolved and were tested by a targeted panel of 17 genes (ACTB, ACTG1, ARX, CRADD, DCX, LIS1, TUBA1A, TUBA8, TUBB2B, TUBB, TUBB3, TUBG1, KIF2A, KIF5C, DYNC1H1, RELN, and VLDLR) or by whole-exome sequencing...
April 19, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29669529/improving-quality-of-life-through-the-routine-use-of-the-patient-concerns-inventory-for-head-and-neck-cancer-patients-a-cluster-preference-randomized-controlled-trial
#9
Simon N Rogers, Derek Lowe, Cher Lowies, Seow Tien Yeo, Christine Allmark, Dominic Mcavery, Gerald M Humphris, Robert Flavel, Cherith Semple, Steven J Thomas, Anastasios Kanatas
BACKGROUND: The consequences of treatment for Head and Neck cancer (HNC) patients has profound detrimental impacts such as impaired QOL, emotional distress, delayed recovery and frequent use of healthcare. The aim of this trial is to determine if the routine use of the Patients Concerns Inventory (PCI) package in review clinics during the first year following treatment can improve overall quality of life, reduce the social-emotional impact of cancer and reduce levels of distress. Furthermore, we aim to describe the economic costs and benefits of using the PCI...
April 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29669181/racial-disparity-in-oncologic-and-quality-of-life-outcomes-in-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinomas-enrolled-in-a-randomized-phase-2-trial
#10
Margaret K Guerriero, Mary W Redman, Kelsey K Baker, Renato G Martins, Keith Eaton, Laura Q Chow, Rafael Santana-Davila, Christina Baik, Bernardo H Goulart, Sylvia Lee, Cristina P Rodriguez
BACKGROUND: To better understand patient-reported quality of life (PRQOL) for patients with head and neck cancer, PRQOL scores were collected in a clinical trial. METHODS: Patients were randomized to arm A (70 Gy of radiation with cisplatin) or arm B (70 Gy of radiation with cisplatin plus erlotinib at 150 mg daily). PRQOL scores were measured on days -7 (arm B only), 0, 30, and 180 with the University of Washington Quality of Life Questionnaire. Associations with clinical factors and outcomes were explored with linear mixed, logistic, and Cox regression models...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29668527/opioid-and-benzodiazepine-use-before-injury-among-workers-in-washington-state-2012-2015
#11
Esi W Nkyekyer, Deborah Fulton-Kehoe, June Spector, Gary Franklin
OBJECTIVE: To characterize pre-injury prescription opioid and benzodiazepine use and its relationship with post-injury use and missed work among workers. METHODS: 313,543 Washington State Department of Labor and Industries workers' compensation injury claims from 2012-2015 were linked with State Prescription Monitoring Program data. Pre-injury prevalence of opioid and benzodiazepine use were compared between compensable and non-compensable claims, and between workers with and without post-injury prescriptions, using the Pearson Chi-Square test...
April 17, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29657856/collaborative-academic-medical-product-development-an-8-year-review-of-commercialization-outcomes-at-the-institute-of-translational-health-sciences
#12
Lynn M Rose, Fiona Wills, Connie Bourassa-Shaw, Terri L Butler, Jeanette Griscavage Ennis, Kim Emmons, Patrick Shelby, Meher Antia, Kim Folger Bruce
Introduction: The Institute of Translational Health Sciences (ITHS), a Clinical and Translational Science Award (CTSA)-funded program at the University of Washington (UW), established the Drug and Device Advisory Committee (DDAC) to provide product-specific scientific and regulatory mentoring to investigators seeking to translate their discoveries into medical products. An 8-year retrospective analysis was undertaken to evaluate the impact of the DDAC programs on commercialization metrics...
August 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29656899/long-term-outcome-of-patients-with-or-without-osseointegrated-implants-after-resection-of-mandibular-ameloblastoma-and-reconstruction-with-vascularized-bone-graft-functional-assessment-and-quality-of-life
#13
Marco Pappalardo, Chung-Kan Tsao, Man Lung Tsang, Jie Zheng, Yang-Ming Chang, Chi-Ying Tsai
BACKGROUND: The optimal management after the resection of mandibular ameloblastoma has been very challenging to surgeons. The aim of this study is to evaluate the functional, aesthetic, and quality of life outcomes of patients who had a segmental mandibular resection and immediate reconstruction with or without osseointegrated implants. METHOD: Patients' demographics, tumor characteristics, treatment, and complications were retrieved. Patients were divided into two groups: dental rehabilitated vs...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29652736/recommendations-and-extraction-of-clinical-variables-of-pediatric-multiple-sclerosis-using-common-data-elements
#14
Pamela Newland, John M Newland, Verna L Hendricks-Ferguson, Judith M Smith, Brant J Oliver
PURPOSE: The purpose of this article was to demonstrate the feasibility of using common data elements (CDEs) to search for information on the pediatric patient with multiple sclerosis (MS) and provide recommendations for future quality improvement and research in the use of CDEs for pediatric MS symptom management strategies Methods: The St. Louis Children's Hospital (SLCH), Washington University (WU) pediatrics data network was evaluated for use of CDEs identified from a database to identify variables in pediatric MS, including the key clinical features from the disease course of MS...
April 12, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29643713/modified-conjunctival-flap-as-a-primary-procedure-for-nontraumatic-acute-corneal-perforation
#15
Yi-Chen Sun, Jason P Kam, Tueng T Shen
Objective: Appropriate management of nontraumatic acute corneal perforation is always a challenge even with the many advances in surgical materials and techniques. We reported the outcomes of a case series of acute corneal perforation repair using a newly modified conjunctival flap with amniotic membrane transplant (AMT), fibrin glue, and a bandage soft contact lens (BCL). Materials and Methods: A total of 13 consecutive referral cases with nontraumatic acute corneal perforation at the University of Washington were reviewed...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29643160/using-machine-learning-techniques-to-develop-forecasting-algorithms-for-postoperative-complications-protocol-for-a-retrospective-study
#16
Bradley A Fritz, Yixin Chen, Teresa M Murray-Torres, Stephen Gregory, Arbi Ben Abdallah, Alex Kronzer, Sherry Lynn McKinnon, Thaddeus Budelier, Daniel L Helsten, Troy S Wildes, Anshuman Sharma, Michael Simon Avidan
INTRODUCTION: Mortality and morbidity following surgery are pressing public health concerns in the USA. Traditional prediction models for postoperative adverse outcomes demonstrate good discrimination at the population level, but the ability to forecast an individual patient's trajectory in real time remains poor. We propose to apply machine learning techniques to perioperative time-series data to develop algorithms for predicting adverse perioperative outcomes. METHODS AND ANALYSIS: This study will include all adult patients who had surgery at our tertiary care hospital over a 4-year period...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29625025/ltbp3-pathogenic-variants-predispose-individuals-to-thoracic-aortic-aneurysms-and-dissections
#17
Dong-Chuan Guo, Ellen S Regalado, Amelie Pinard, Jiyuan Chen, Kwanghyuk Lee, Christina Rigelsky, Lior Zilberberg, Ellen M Hostetler, Micheala Aldred, Stephanie E Wallace, Siddharth K Prakash, Suzanne M Leal, Michael J Bamshad, Deborah A Nickerson, Marvin Natowicz, Daniel B Rifkin, Dianna M Milewicz
The major diseases affecting the thoracic aorta are aneurysms and acute dissections, and pathogenic variants in 11 genes are confirmed to lead to heritable thoracic aortic disease. However, many families in which multiple members have thoracic aortic disease do not have alterations in the known aortopathy genes. Genes highly expressed in the aorta were assessed for rare variants in exome sequencing data from such families, and compound rare heterozygous variants (p.Pro45Argfs∗ 25 and p.Glu750∗ ) in LTBP3 were identified in affected members of one family...
April 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29616704/minimizing-the-sample-sizes-of-clinical-trials-on-preclinical-and-early-symptomatic-stage-of-alzheimer-disease
#18
J Luo, H Weng, J C Morris, C Xiong
BACKGROUND: Clinical trials of investigational drugs for Alzheimer disease (AD) increasingly focus on the prodromal (symptomatic) stage of the illness and now its preclinical (asymptomatic) stage. Sensitive and specific cognitive and functional endpoints are needed to track subtle cognitive and functional changes in the early and preclinical stages to minimize sample sizes in these trials. OBJECTIVES: To identify informative items in a standard clinical assessment protocol and a psychometric battery that are predictive of onset of dementia symptom...
2018: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29610395/the-future-of-cancer-treatment-using-precision-oncogenomics
#19
Lukas D Wartman
Clinicians should soon have the opportunity to use precision oncogenomics to tailor the optimal cancer treatment to a specific patient. Precision oncogenomics will incorporate different sequencing platforms depending on the goal of the sequencing result. For example, the sequencing strategy used in immuno-oncology for the design of a tumor-specific vaccine may be different than that used by oncologists following a patient for clearance of mutations from circulating tumor DNA in the peripheral blood. I will provide a broad overview of several of the ways that precision oncogenomics is likely to influence the field of oncology over the next several years building off the experience at the Genomics Tumor Board at Washington University in St...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29593936/oral-effects-and-early-implant-survival-results-after-imatinib-discontinuation-therapy-for-chronic-myelogenous-leukemia-a-case-report
#20
Douglas R Dixon, Alaa Yassin
Introduction: Little is known regarding the success, failure, or complication rates of advanced implant procedures in patients after discontinuation therapy of long-term medications for the treatment of chronic myelogenous leukemia (CML). This case report presents initial results of a case involving implant placement in the mandible and maxilla as well as reduction of palatal oral pigmentation in a patient discontinuing long-term tyrosine kinase inhibitor (TKI) therapy for CML. Case Presentation: A 57-year-old male was referred to the Department of Periodontics, University of Washington, Seattle, Washington, for an assessment of edentulous areas (tooth sites #3 and #14) and failing tooth #19...
August 2017: Clinical Advances in Periodontics
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