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https://www.readbyqxmd.com/read/29667765/molecular-profile-of-inflammatory-and-megakaryocytic-factors-in-pediatric-myelodysplastic-syndrome-with-acute-myelofibrosis
#1
Kais Hussein, Meinolf Suttorp, Angelika Stucki-Koch, Irith Baumann, Charlotte M Niemeyer, Hans Kreipe
Pediatric fibrotic myelodysplastic syndromes (ped-MDS-MF) and pediatric primary myelofibrosis (ped-PMF) are rare, and the molecular changes which mediate fibrosis have never been investigated. Histology and gene expression profile of 119 fibrosis/angiogenesis/inflammation/megakaryopoiesis-related factors in bone marrow biopsies were performed (two ped-MDS-MF and one ped-PMF). In one progressive ped-MDS, comparison of MF grade 0 (no myelofibrosis) and MF grade 2 (dense network of reticulin fibres) after 4 months showed that expression of fibrosis-related transcripts increased and dysplastic megakaryocytes formed a dense net of CD42b+ proplatelets...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29666551/impact-of-new-ingredients-obtained-from-brewer-s-spent-yeast-on-bread-characteristics
#2
Z E Martins, O Pinho, I M P L V O Ferreira
The impact of bread fortification with β-glucans and with proteins/proteolytic enzymes from brewers' spent yeast on physical characteristics was evaluated. β-Glucans extraction from spent yeast cell wall was optimized and the extract was incorporated on bread to obtain 2.02 g β-glucans/100 g flour, in order to comply with the European Food Safety Authority guidelines. Protein/proteolytic enzymes extract from spent yeast was added to bread at 60 U proteolytic activity/100 g flour. Both β-glucans rich and proteins/proteolytic enzymes extracts favoured browning of bread crust...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666526/utilization-of-lentil-pea-and-faba-bean-hulls-in-turkish-noodle-production
#3
Esra Kaya, Neşe Yılmaz Tuncel, Necati Barış Tuncel
Turkish noodles (erişte) were substituted with green lentil ( Lens culinaris ), red lentil ( L. culinaris ), faba bean ( Vicia faba ), and pea ( Pisum sativum ) hulls at the level of 2.5, 5, and 10% and the effects of the substitution on proximate composition, mineral composition, colour, cooking properties, thiamine and riboflavin contents, texture and sensory properties of the noodles were investigated. Crude ash, dietary fibre, Ca and Mg contents of the noodles significantly increased with pulse hull substitution regardless of the hull type compared to control...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666452/high-fibre-diet-beneficial-for-t2dm
#4
Ivone Leong
No abstract text is available yet for this article.
April 17, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29666144/sporadic-amyotrophic-lateral-sclerosis-sals-skeletal-muscle-response-to-cerebrospinal-fluid-from-sals-patients-in-a-rat-model
#5
Shruthi Shanmukha, Gayathri Narayanappa, Atchayaram Nalini, Phalguni Anand Alladi, Trichur R Raju
Skeletal muscle atrophy is the most prominent feature of amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease of motor neurons. However, the contribution of skeletal muscle to disease progression remains elusive. Our previous studies have shown that intrathecal injection of cerebrospinal fluid from sporadic ALS patients (ALS-CSF) induces several degenerative changes in motor neurons and glia of neonatal rats. Here, we describe various pathologic events in the rat extensor digitorum longus muscle following intrathecal injection of ALS-CSF...
April 16, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29665013/planhab-hypoxia-does-not-worsen-the-impairment-of-skeletal-muscle-oxidative-function-induced-by-bed-rest-alone
#6
Desy Salvadego, Michail E Keramidas, Roger Kölegård, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Jörn Rittweger, Ola Eiken, Igor B Mekjavic, Bruno Grassi
KEY POINTS: Superposition of hypoxia on 21 day bed rest did not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. A significant impairment of maximal oxidative performance was identified downstream of cardiovascular O2 delivery, involving both the intramuscular matching between O2 supply and utilization and mitochondrial respiration. These chronic adaptations appear to be relevant in terms of exposure to spaceflights and reduced gravity habitats (Moon or Mars), as characterized by low gravity and hypoxia, in patients with chronic diseases characterized by hypomobility/immobility and hypoxia, as well as in ageing...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29664900/accuracy-and-precision-of-scvo2-measured-with-the-cevox-device-a-prospective-study-in-patients-with-a-wide-variation-of-scvo2-values
#7
Alexander Herner, Bernhard Haller, Ulrich Mayr, Sebastian Rasch, Lea Offman, Roland Schmid, Wolfgang Huber
INTRODUCTION: Central-venous oxygen saturation (ScvO2) is a key parameter of hemodynamic monitoring and has been suggested as therapeutic goal for resuscitation. Several devices offer continuous monitoring features. The CeVOX-device (Pulsion Medical Systems) uses a fibre-optic probe inserted through a conventional central-venous catheter (CVC) to obtain continuous ScvO2. OBJECTIVES: Since there is a lack of studies validating the CeVOX, we prospectively analyzed data from 24 patients with CeVOX-monitoring...
2018: PloS One
https://www.readbyqxmd.com/read/29663403/smoke-induced-neuromuscular-junction-degeneration-precedes-the-fibre-type-shift-and-atrophy-in-copd
#8
Sophia Kapchinsky, Madhusudanarao Vuda, Kayla Miguez, Daren Elkrief, Angela R de Souza, Carolyn J Baglole, Sudhakar Aare, Norah J MacMillan, Jacinthe Baril, Paul Rozakis, Vita Sonjak, Charlotte Pion, Mylène Aubertin-Leheudre, Jose A Morais, R Thomas Jagoe, Jean Bourbeau, Tanja Taivassalo, Russell T Hepple
A neurological basis for the fast fibre shift and atrophy seen in limb muscle of patients with chronic obstructive pulmonary disease (COPD) has not been considered previously. The objective of our study was: (i) to determine if denervation contributes to fast fibre shift and muscle atrophy in COPD; and (ii) to assess using a preclinical smoking mouse model whether chronic tobacco smoke (TS) exposure could initiate denervation by causing neuromuscular junction (NMJ) degeneration. Vastus lateralis muscle biopsies were obtained from severe COPD patients (n = 10 with low fat free mass index [FFMI], 65 y; n = 15 normal FFMI, 65 y) and healthy age- and activity-matched non-smoker control subjects (CON; n = 11, 67 y), to evaluate morphological and transcriptional markers of denervation...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29663400/effects-of-natural-blends-of-garlic-and-eucalyptuis-essential-oils-on-biogas-production-of-four-fibrous-feeds-at-short-term-of-incubation-in-the-ruminal-anaerobic-biosystem
#9
M M Y Elghandour, M Z M Salem, R Greiner, A Z M Salem
BACKGROUND: This study explored the effect of garlic and/or eucalyptus oils on biogas production during in vitro ruminal fermentation of four agro industry byproducts. 0 to 180 mg of the oils per litre incubation medium was added and the gas volumes were recorded from 2 to 48 h of incubation. Dry matter substrate degradability and neutral as well as acid detergent fibre were determined after 72 h. RESULT: Gas production and nutrients degradability was oil type dependent...
April 16, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29661648/one-year-rat-study-of-ibta-induced-microbiotube-microvascular-grafts-with-an-ultra-small-diameter-of-0-6-mm
#10
Daizo Ishii, Jun-Ichiro Enmi, Ryosuke Iwai, Kaoru Kurisu, Eisuke Tatsumi, Yasuhide Nakayama
OBJECTIVE: The world's smallest calibre "microbiotube" vascular graft was recently developed, with an inner diameter of 0.6 mm. It was formed using in-body tissue architecture (iBTA) and has a high degree of patency and capacity for regeneration in the acute phase, 1 month after implantation. This consecutive study investigated the compatibility and stability of microbiotubes in the chronic phase of implantation for 12 months for potential application in microsurgery. METHODS: This was an in vivo experimental study...
April 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29661379/isoflurane-disrupts-excitatory-neurotransmitter-dynamics-via-inhibition-of-mitochondrial-complex-i
#11
P I Zimin, C B Woods, E B Kayser, J M Ramirez, P G Morgan, M M Sedensky
BACKGROUND: The mechanisms of action of volatile anaesthetics are unclear. Volatile anaesthetics selectively inhibit complex I in the mitochondrial respiratory chain. Mice in which the mitochondrial complex I subunit NDUFS4 is knocked out [Ndufs4(KO)] either globally or in glutamatergic neurons are hypersensitive to volatile anaesthetics. The volatile anaesthetic isoflurane selectively decreases the frequency of spontaneous excitatory events in hippocampal slices from Ndufs4(KO) mice...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29661311/isolation-and-characterisation-of-microcrystalline-cellulose-and-cellulose-nanocrystals-from-coffee-husk-and-comparative-study-with-rice-husk
#12
Sofía Collazo-Bigliardi, Rodrigo Ortega-Toro, Amparo Chiralt Boix
Cellulosic material from coffee husk has not been previously studied despite being a potential source of reinforcing agents for different applications. This material has been extracted and characterised from coffee husk, in parallel with previously studied rice husk. Samples have been analysed as to their ability to obtain cellulosic fibres and cellulose nanocrystals (CNC) by applying alkali and bleaching treatments and final sulphuric acid hydrolysis. Microstructural changes were analysed after treatments, and the size and aspect ratio of CNCs were determined...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29661175/adherence-to-the-qatar-dietary-guidelines-a-cross-sectional-study-of-the-gaps-determinants-and-association-with-cardiometabolic-risk-amongst-adults
#13
Mohammed Al Thani, Al Anoud Al Thani, Walaa Al-Chetachi, Badria Al Malki, Shamseldin A H Khalifa, Ahmad Haj Bakri, Nahla Hwalla, Farah Naja, Lara Nasreddine
BACKGROUND: The Qatar Dietary Guidelines (QDGs) were developed as part of the national strategy to prevent chronic diseases. This study aims at characterizing gaps between the QDGs and usual dietary and lifestyle patterns in Qatar, identifying demographic and socioeconomic determinants of adherence to the QDGs and investigating the association between adherence and cardiometabolic risk. METHODS: This study is based on the Qatar National STEPwise cross-sectional survey which was conducted on a nationally representative sample of Qatari adults, aged 18 to 64 years (n = 1109)...
April 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29661113/histology-vascularity-and-innervation-of-the-glenoid-labrum
#14
Abduelmenem Alashkham, Abdulrahman Alraddadi, Paul Felts, Roger Soames
BACKGROUND: Although the glenoid labrum has an important role in shoulder stability, little is known about its composition, vascularity and innervation. The aims of this study were therefore to evaluate the histology, vascularity and innervation of the glenoid labrum. MATERIALS AND METHODS: Ten glenoid labrum specimens (three male, two female: mean age 81.2 years, range 76-90 years) were detached at the glenoid neck. Following decalcification, sections were cut through the whole thickness of each specimen perpendicular to the glenoid labrum at 12 radii corresponding to a clock face superimposed on the glenoid fossa...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29661028/development-of-large-scale-manufacturing-of-adipose-derived-stromal-cells-for-clinical-applications-using-bioreactors-and-human-platelet-lysate
#15
Mandana Haack-Sørensen, Morten Juhl, Bjarke Follin, Rebekka Harary Søndergaard, Maria Kirchhoff, Jens Kastrup, Annette Ekblond
In vitro expanded adipose-derived stromal cells (ASCs) are a useful resource for tissue regeneration. Translation of small-scale autologous cell production into a large-scale, allogeneic production process for clinical applications necessitates well-chosen raw materials and cell culture platform. We compare the use of clinical-grade human platelet lysate (hPL) and fetal bovine serum (FBS) as growth supplements for ASC expansion in the automated, closed hollow fibre quantum cell expansion system (bioreactor)...
April 17, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29660325/a1603p-and-k1617del-mutations-in-%C3%AE-cardiac-myosin-heavy-chain-that-cause-laing-early-onset-distal-myopathy-affect-secondary-structure-and-filament-formation-in-vitro-and-in-vivo
#16
Francine Parker, Matthew Batchelor, Marcin Wolny, Ruth Hughes, Peter J Knight, Michelle Peckham
Over 20 mutations in β-cardiac myosin heavy chain (β-MHC), expressed in cardiac and slow muscle fibres, cause Laing early onset distal myopathy (MPD-1), a skeletal muscle myopathy. Most of these mutations are in the coiled-coil tail, and commonly involve a mutation to a proline, or a single residue deletion, both of which are predicted to strongly affect the secondary structure of the coiled coil. To test this, we characterised the effects of two MPD-1 causing mutations: A1603P and K1617del in vitro and in cells...
April 13, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29659778/impact-of-diabetes-mellitus-on-the-contractile-properties-of-the-left-and-right-atrial-myofilaments
#17
Constanze Bening, Khaled Alhussini, Elena-Aura Mazalu, Jonathan Yaqub, Khaled Hamouda, Dejan Radakovic, Christoph Schimmer, Grzegorz Hirnle, Rainer Leyh
OBJECTIVES: The incidence of diabetes mellitus in patients with ischaemic cardiomyopathy is increasing. To evaluate the impact of diabetes mellitus on contractility, we examined the calcium-induced force in left and right atrial myofilaments of patients with and without diabetes. METHODS: We included 149 patients (106 without diabetes, 43 with diabetes), scheduled for elective coronary artery bypass grafting from August 2016 to June 2017. The left and right atria were excised and prepared for skinned fibre measurements (pCa-force curve)...
April 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29659487/cultivar-and-harvest-month-influence-the-nutrient-content-of-opuntia-spp-cactus-pear-cladode-mucilage-extracts
#18
Alba du Toit, Maryna de Wit, Arno Hugo
Mucilage extracted from cactus pear cladodes is a hydrocolloid gum. It is a novel, natural, low-kilojoule, cost-effective texture-modifying ingredient in functional food products. Yet, the cultivar with the most optimal nutrient content and the preferred harvest times are as yet unknown. For this reason, mucilage from three Opuntia ficus-indica (Algerian, Morado and Gymno-Carpo) and one Opuntia robusta (Robusta) cultivar were investigated to determine their nutrient content over six months. Nutrients that contribute energy (10...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29657975/visual-pathway-function-and-structure-in-wolfram-syndrome-patient-age-variation-and-progression
#19
James Hoekel, Anagha Narayanan, Jerrel Rutlin, Heather Lugar, Amal Al-Lozi, Tamara Hershey, Lawrence Tychsen
Background/aims: To report alterations in visual acuity and visual pathway structure over an interval of 1-3 years in a cohort of children, adolescents and young adults who have Wolfram syndrome (WFS) and to describe the range of disease severity evident in patients with WFS whose ages differed by as much as 20 years at first examination. Methods: Annual, prospective ophthalmological examinations were performed in conjunction with retinal nerve fibre layer (RNFL) analysis...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/29657773/preparation-characterization-and-luminescence-properties-of-core-shell-ternary-terbium-composites-sio-2-600-tb-maba-si-%C3%A2-l
#20
Yang-Yang Ma, Wen-Xian Li, Yu-Shan Zheng, Jin-Rong Bao, Yi-Lian Li, Li-Na Feng, Kui-Suo Yang, Yan Qiao, An-Ping Wu
Two novel core-shell structure ternary terbium composites SiO2(600) @Tb(MABA-Si)·L(L:dipy/phen) nanometre luminescence materials were prepared by ternary terbium complexes Tb(MABA-Si)·L2 ·(ClO4 )3 ·2H2 O shell grafted onto the surface of SiO2 microspheres. And corresponding ternary terbium complexes were synthesized using (CONH(CH2 )3 Si(OCH2 CH3 )3 )2 (denoted as MABA-Si) as first ligand and L as second ligand coordinated with terbium perchlorate. The as-synthesized products were characterized by means of IR spectra, 1 HNMR, element analysis, molar conductivity, SEM and TEM...
March 2018: Royal Society Open Science
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