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Laminin-211

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https://www.readbyqxmd.com/read/27859941/adhesion-g-protein-coupled-receptors-and-extracellular-matrix-proteins-roles-in-myelination-and-glial-cell-development
#1
REVIEW
Paulomi Mehta, Xianhua Piao
BACKGROUND: Adhesion G protein-coupled receptors (aGPCRs) are a large family of transmembrane proteins that play important roles in many processes during development, primarily through cell-cell and cell-extracellular matrix (ECM) interactions. In the nervous system, they have been linked to the complex process of myelination, both in the central and peripheral nervous system. RESULTS: GPR126 is essential in Schwann cell-mediated myelination in the peripheral nervous system (PNS), while GPR56 is involved in oligodendrocyte development central nervous system (CNS) myelination...
November 18, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27791138/laminin-targeting-of-a-peripheral-nerve-highlighting-peptide-enables-degenerated-nerve-visualization
#2
Heather L Glasgow, Michael A Whitney, Larry A Gross, Beth Friedman, Stephen R Adams, Jessica L Crisp, Timon Hussain, Andreas P Frei, Karel Novy, Bernd Wollscheid, Quyen T Nguyen, Roger Y Tsien
Target-blind activity-based screening of molecular libraries is often used to develop first-generation compounds, but subsequent target identification is rate-limiting to developing improved agents with higher specific affinity and lower off-target binding. A fluorescently labeled nerve-binding peptide, NP41, selected by phage display, highlights peripheral nerves in vivo. Nerve highlighting has the potential to improve surgical outcomes by facilitating intraoperative nerve identification, reducing accidental nerve transection, and facilitating repair of damaged nerves...
October 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27663298/laminin-%C3%AE-2-secreting-fibroblasts-enhance-the-therapeutic-effect-of-skeletal-myoblast-sheets
#3
Ayako Uchinaka, Kanako Tasaka, Yoko Mizuno, Yoshitaka Maeno, Tsuyoshi Ban, Seiji Mori, Yoshinosuke Hamada, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Nariaki Matsuura, Kohzo Nagata, Hirofumi Yamamoto, Naomasa Kawaguchi
OBJECTIVES: Skeletal myoblast sheet (SMB) transplantation, a method used for treating failing hearts, results in the secretion of cytokines that improve heart function. Enhancing the survival rate of implanted myoblasts should yield more continuous and effective therapies. We hypothesized that laminin-211 (merosin), a major component of skeletal muscle extracellular matrix (ECM), which mediates cell-to-ECM adhesion by binding to α-dystroglycan (αDG) on muscle cells, could inhibit detachment of implanted myoblasts from host myocardia...
September 23, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27234308/deletion-of-the-epidermis-derived-laminin-%C3%AE-1-chain-leads-to-defects-in-the-regulation-of-late-hair-morphogenesis
#4
Anja Fleger-Weckmann, Yasemin Üstün, Jennifer Kloepper, Ralf Paus, Wilhelm Bloch, Zu-Lin Chen, Jeannine Wegner, Lydia Sorokin, Lutz Langbein, Beate Eckes, Paola Zigrino, Thomas Krieg, Roswitha Nischt
Laminins are the most abundant non-collagenous basement membrane (BM) components, composed of an α, β and γ chain. The laminin γ1 chain, encoded by LAMC1, is the most abundant γ chain. The main laminin isoforms in the dermo-epidermal junction (DEJ) are laminin-332, laminin-511 and laminin-211, the latter being restricted to the lower part of hair follicles (HFs). Complete deletion of LAMC1 results in lethality around embryonic day 5.5. To study the function of laminin γ1 containing isoforms in skin development and maturation after birth, we generated mice lacking LAMC1 expression in basal keratinocytes (LAMC1(EKO)) using the keratin 14 (K14) Cre/loxP system...
December 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27165837/endothelin-a-receptor-activation-on-mesangial-cells%C3%A2-initiates-alport-glomerular-disease
#5
Brianna Dufek, Daniel T Meehan, Duane Delimont, Linda Cheung, Michael Anne Gratton, Grady Phillips, Wenping Song, Shiguang Liu, Dominic Cosgrove
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the subcapillary spaces by mesangial filopodia. The filopodia deposit mesangial matrix proteins in the glomerular basement membrane, including laminin 211, which activates focal adhesion kinase in podocytes culminating in the up-regulation of proinflammatory cytokines and metalloproteinases...
August 2016: Kidney International
https://www.readbyqxmd.com/read/26610911/laminin-%C3%AE-2-chain-deficient-congenital-muscular-dystrophy-pathophysiology-and-development-of-treatment
#6
REVIEW
Madeleine Durbeej
Laminin-211 is a major constituent of the skeletal muscle basement membrane. It stabilizes skeletal muscle and influences signal transduction events from the myomatrix to the muscle cell. Mutations in the gene encoding the α2 chain of laminin-211 lead to congenital muscular dystrophy type 1A (MDC1A), a life-threatening disease characterized by severe hypotonia, progressive muscle weakness, and joint contractures. Common complications include severely impaired motor ability, respiratory failure, and feeding difficulties...
2015: Current Topics in Membranes
https://www.readbyqxmd.com/read/26355035/deletion-of-integrin-%C3%AE-7-subunit-does-not-aggravate-the-phenotype-of-laminin-%C3%AE-2-chain-deficient-mice
#7
Kinga I Gawlik, Madeleine Durbeej
Laminin-211 is a major constituent of the skeletal muscle basement membrane, exerting its biological functions by binding to cell surface receptors integrin α7β1 and dystroglycan (the latter is part of the dystrophin-glycoprotein complex). The importance of these molecules for normal muscle function is underscored by the fact that their respective deficiency leads to different forms of muscular dystrophy with different severity in humans and animal models. We recently demonstrated that laminin α2 chain and members of the dystrophin-glycoprotein complex have overlapping but non-redundant roles despite being part of the same adhesion complex...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26347253/mesoangioblast-delivery-of-miniagrin-ameliorates-murine-model-of-merosin-deficient-congenital-muscular-dystrophy-type-1a
#8
Teuta Domi, Emanuela Porrello, Daniele Velardo, Alessia Capotondo, Alessandra Biffi, Rossana Tonlorenzi, Stefano Amadio, Alessandro Ambrosi, Yuko Miyagoe-Suzuki, Shin'ichi Takeda, Markus A Ruegg, Stefano Carlo Previtali
BACKGROUND: Merosin-deficient congenital muscular dystrophy type-1A (MDC1A) is characterized by progressive muscular dystrophy and dysmyelinating neuropathy caused by mutations of the α2 chain of laminin-211, the predominant laminin isoform of muscles and nerves. MDC1A has no available treatment so far, although preclinical studies showed amelioration of the disease by the overexpression of miniagrin (MAG). MAG reconnects orphan laminin-211 receptors to other laminin isoforms available in the extracellular matrix of MDC1A mice...
2015: Skeletal Muscle
https://www.readbyqxmd.com/read/26171643/laminin-promotes-metalloproteinase-mediated-dystroglycan-processing-to-regulate-oligodendrocyte-progenitor-cell-proliferation
#9
Cindy V Leiton, Azeez Aranmolate, Christopher Eyermann, Michael J Menezes, Luisa F Escobar-Hoyos, Solomon Husain, Steve J Winder, Holly Colognato
The cell surface receptor dystroglycan mediates interactions between oligodendroglia and laminin-211, an extracellular matrix protein that regulates timely oligodendroglial development. However, dystroglycan's precise role in oligodendroglial development and the potential mechanisms to regulate laminin-dystroglycan interactions remain unknown. Here we report that oligodendroglial dystroglycan is cleaved by metalloproteinases, thereby uncoupling oligodendroglia from laminin binding. Dystroglycan cleavage is selectively stimulated by oligodendrocyte progenitor cell attachment to laminin-211, but not laminin-111 or poly-D-lysine...
November 2015: Journal of Neurochemistry
https://www.readbyqxmd.com/read/25695270/the-adhesion-gpcr-gpr126-has-distinct-domain-dependent-functions-in-schwann-cell-development-mediated-by-interaction-with-laminin-211
#10
Sarah C Petersen, Rong Luo, Ines Liebscher, Stefanie Giera, Sung-Jin Jeong, Amit Mogha, Monica Ghidinelli, M Laura Feltri, Torsten Schöneberg, Xianhua Piao, Kelly R Monk
Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor GPR126, which undergoes autoproteolytic cleavage into an N-terminal fragment (NTF) and a seven-transmembrane-containing C-terminal fragment (CTF). Here we show that GPR126 has domain-specific functions in SC development whereby the NTF is necessary and sufficient for axon sorting, whereas the CTF promotes wrapping through cAMP elevation...
February 18, 2015: Neuron
https://www.readbyqxmd.com/read/25392494/the-extracellular-matrix-protein-laminin-%C3%AE-2-regulates-the-maturation-and-function-of-the-blood-brain-barrier
#11
Michael J Menezes, Freyja K McClenahan, Cindy V Leiton, Azeez Aranmolate, Xiwei Shan, Holly Colognato
Laminins are major constituents of the gliovascular basal lamina of the blood-brain barrier (BBB); however, the role of laminins in BBB development remains unclear. Here we report that Lama2(-/-) mice, lacking expression of the laminin α2 subunit of the laminin-211 heterotrimer expressed by astrocytes and pericytes, have a defective BBB in which systemically circulated tracer leaks into the brain parenchyma. The Lama2(-/-) vascular endothelium had significant abnormalities, including altered integrity and composition of the endothelial basal lamina, inappropriate expression of embryonic vascular endothelial protein MECA32, substantially reduced pericyte coverage, and tight junction abnormalities...
November 12, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/24720953/laminin-%C3%AE-1-regulates-age-related-mesangial-cell-proliferation-and-mesangial-matrix-accumulation-through-the-tgf-%C3%AE-pathway
#12
Liang Ning, Hidetake Kurihara, Susana de Vega, Naoki Ichikawa-Tomikawa, Zhuo Xu, Risa Nonaka, Saiko Kazuno, Yoshihiko Yamada, Jeffrey H Miner, Eri Arikawa-Hirasawa
Laminin α1 (LAMA1), a subunit of the laminin-111 basement membrane component, has been implicated in various biological functions in vivo and in vitro. Although LAMA1 is present in kidney, its roles in the kidney are unknown because of early embryonic lethality. Herein, we used a viable conditional knockout mouse model with a deletion of Lama1 in the epiblast lineage (Lama1(CKO)) to study the role of LAMA1 in kidney development and function. Adult Lama1(CKO) mice developed focal glomerulosclerosis and proteinuria with age...
June 2014: American Journal of Pathology
https://www.readbyqxmd.com/read/24709677/clinical-pathologic-and-mutational-spectrum-of-dystroglycanopathy-caused-by-large-mutations
#13
Katherine G Meilleur, Kristen Zukosky, Livija Medne, Pierre Fequiere, Nina Powell-Hamilton, Thomas L Winder, Abdulaziz Alsaman, Ayman W El-Hattab, Jahannaz Dastgir, Ying Hu, Sandra Donkervoort, Jeffrey A Golden, Ralph Eagle, Richard Finkel, Mena Scavina, Ian C Hood, Lucy B Rorke-Adams, Carsten G Bönnemann
Dystroglycanopathies are a subtype of congenital muscular dystrophy of varying severity that can affect the brain and eyes, ranging from Walker-Warburg syndrome with severe brain malformation to milder congenital muscular dystrophy presentations with affected or normal cognition and later onset. Mutations in dystroglycanopathy genes affect a specific glycoepitope on α-dystroglycan; of the 14 genes implicated to date, LARGE encodes the glycosyltransferase that adds the final xylose and glucuronic acid, allowing α-dystroglycan to bind ligands, including laminin 211 and neurexin...
May 2014: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/24227711/%C3%AE-6%C3%AE-1-and-%C3%AE-7%C3%AE-1-integrins-are-required-in-schwann-cells-to-sort-axons
#14
Marta Pellegatta, Adèle De Arcangelis, Alessandra D'Urso, Alessandro Nodari, Desirée Zambroni, Monica Ghidinelli, Vittoria Matafora, Courtney Williamson, Elisabeth Georges-Labouesse, Jordan Kreidberg, Ulrike Mayer, Karen K McKee, Peter D Yurchenco, Angelo Quattrini, Lawrence Wrabetz, Maria Laura Feltri
During development, Schwann cells extend lamellipodia-like processes to segregate large- and small-caliber axons during the process of radial sorting. Radial sorting is a prerequisite for myelination and is arrested in human neuropathies because of laminin deficiency. Experiments in mice using targeted mutagenesis have confirmed that laminins 211, 411, and receptors containing the β1 integrin subunit are required for radial sorting; however, which of the 11 α integrins that can pair with β1 forms the functional receptor is unknown...
November 13, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/24009313/laminin-111-improves-muscle-repair-in-a-mouse-model-of-merosin-deficient-congenital-muscular-dystrophy
#15
Pam M Van Ry, Priscilla Minogue, Bradley L Hodges, Dean J Burkin
Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is a severe and fatal muscle-wasting disease with no cure. MDC1A patients and the dy(W-/-) mouse model exhibit severe muscle weakness, demyelinating neuropathy, failed muscle regeneration and premature death. We have recently shown that laminin-111, a form of laminin found in embryonic skeletal muscle, can substitute for the loss of laminin-211/221 and prevent muscle disease progression in the dy(W-/-) mouse model. What is unclear from these studies is whether laminin-111 can restore failed regeneration to laminin-α2-deficient muscle...
January 15, 2014: Human Molecular Genetics
https://www.readbyqxmd.com/read/23911822/%C3%AE-1%C3%AE-1-integrin-rac1-dependent-mesangial-invasion-of-glomerular-capillaries-in-alport-syndrome
#16
Marisa Zallocchi, Brianna M Johnson, Daniel T Meehan, Duane Delimont, Dominic Cosgrove
Alport syndrome, hereditary glomerulonephritis with hearing loss, results from mutations in type IV collagen COL4A3, COL4A4, or COL4A5 genes. The mechanism for delayed glomerular disease onset is unknown. Comparative analysis of Alport mice and CD151 knockout mice revealed progressive accumulation of laminin 211 in the glomerular basement membrane. We show mesangial processes invading the capillary loops of both models as well as in human Alport glomeruli, as the likely source of this laminin. L-NAME salt-induced hypertension accelerated mesangial cell process invasion...
October 2013: American Journal of Pathology
https://www.readbyqxmd.com/read/23797810/integrin-%C3%AE-6%C3%AE-1-is-the-main-receptor-for-vascular-laminins-and-plays-a-role-in-platelet-adhesion-activation-and-arterial-thrombosis
#17
Mathieu Schaff, ChaoJun Tang, Eric Maurer, Catherine Bourdon, Nicolas Receveur, Anita Eckly, Béatrice Hechler, Christiane Arnold, Adèle de Arcangelis, Bernhard Nieswandt, Cécile V Denis, Olivier Lefebvre, Elisabeth Georges-Labouesse, Christian Gachet, François Lanza, Pierre H Mangin
BACKGROUND: Laminins are major components of basement membranes, well located to interact with platelets upon vascular injury. Laminin-111 (α1β1γ1) is known to support platelet adhesion but is absent from most blood vessels, which contain isoforms with the α2, α4, or α5 chain. Whether vascular laminins support platelet adhesion and activation and the significance of these interactions in hemostasis and thrombosis remain unknown. METHODS AND RESULTS: Using an in vitro flow assay, we show that laminin-411 (α4β1γ1), laminin-511 (α5β1γ1), and laminin-521 (α5β2γ1), but not laminin-211 (α2β1γ1), allow efficient platelet adhesion and activation across a wide range of arterial wall shear rates...
July 30, 2013: Circulation
https://www.readbyqxmd.com/read/23756649/laminin-drives-survival-signals-to-promote-a-contractile-smooth-muscle-phenotype-and-airway-hyperreactivity
#18
Thai Tran, Chun Ming Teoh, John Kit Chung Tam, Yongkang Qiao, Chin Yein Chin, Oi Khuan Chong, Alastair G Stewart, Trudi Harris, Wai Shiu Fred Wong, Shou Ping Guan, Bernard P Leung, William T Gerthoffer, Helmut Unruh, Andrew J Halayko
Increased airway smooth muscle (ASM) mass is believed to underlie the relatively fixed airway hyperresponsiveness (AHR) in asthma. Developments of therapeutic approaches to reverse airway remodeling are impeded by our lack of insight on the mechanisms behind the increase in mass of contractile ASM cells. Increased expression of laminin, an extracellular matrix protein, is associated with asthma. Our studies investigate the role of laminin-induced ASM survival signals in the development of increased ASM and AHR...
October 2013: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/23154401/laminin-211-in-skeletal-muscle-function
#19
REVIEW
Johan Holmberg, Madeleine Durbeej
A chain is no stronger than its weakest link is an old idiom that holds true for muscle biology. As the name implies, skeletal muscle's main function is to move the bones. However, for a muscle to transmit force and withstand the stress that contractions give rise to, it relies on a chain of proteins attaching the cytoskeleton of the muscle fiber to the surrounding extracellular matrix. The importance of this attachment is illustrated by a large number of muscular dystrophies caused by interruption of the cytoskeletal-extracellular matrix interaction...
January 2013: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/23026198/four-protein-signature-accurately-predicts-lymph-node-metastasis-and-survival-in-oral-squamous-cell-carcinoma
#20
Sharifah Nurain Syed Zanaruddin, Amyza Saleh, Yi-Hsin Yang, Sharifah Hamid, Wan Mahadzir Wan Mustafa, A A N Khairul Bariah, Rosnah Binti Zain, Shin Hin Lau, Sok Ching Cheong
The presence of lymph node (LN) metastasis significantly affects the survival of patients with oral squamous cell carcinoma (OSCC). Successful detection and removal of positive LNs are crucial in the treatment of this disease. Current evaluation methods still have their limitations in detecting the presence of tumor cells in the LNs, where up to a third of clinically diagnosed metastasis-negative (N0) patients actually have metastasis-positive LNs in the neck. We developed a molecular signature in the primary tumor that could predict LN metastasis in OSCC...
March 2013: Human Pathology
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