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https://www.readbyqxmd.com/read/29929159/methodological-factors-influencing-inhalation-bioaccessibility-of-metal-loid-s-in-pm-2-5-using-simulated-lung-fluid
#1
Farzana Kastury, E Smith, Ranju R Karna, Kirk G Scheckel, A L Juhasz
In this study, methodological factors influencing the dissolution of metal(loid)s in simulated lung fluid (SLF) was assessed in order to develop a standardised method for the assessment of inhalation bioaccessibility in PM2.5 . To achieve this aim, the effects of solid to liquid (S/L) ratio (1:100 to 1:5000), agitation (magnetic agitation, occasional shaking, orbital and end-over-end rotation), composition of SLF (artificial lysosomal fluid: ALF; phagolysosomal simulant fluid: PSF) and extraction time (1-120 h) on metal(loid) bioaccessibility were investigated using PM2...
June 7, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29929119/in-vitro-metabolomics-to-evaluate-toxicity-of-particulate-matter-under-environmentally-realistic-conditions
#2
Francisco Sánchez-Soberón, Matthias Cuykx, Noemí Serra, Victoria Linares, Montserrat Bellés, Adrian Covaci, Marta Schuhmacher
In this pilot study three fractions of particulate matter (PM0.25 , PM2.5-0.25 , and PM10-2.5 ) were collected in three environments (classroom, home, and outdoors) in a village located nearby an industrial complex. Time-activity pattern of 20 students attending the classroom was obtained, and the dose of particles reaching the children's lungs under actual environmental conditions (i.e. real dose) was calculated via dosimetry model. The highest PM concentrations were reached in the classroom. Simulations showed that heavy intensity outdoor activities played a major role in PM deposition, especially in the upper part of the respiratory tract...
June 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29929000/telmisartan-generates-ros-dependent-upregulation-of-death-receptor-5-to-sensitize-trail-in-lung-cancer-via-inhibition-of-autophagy-flux
#3
Mohammad Rasheduzzaman, Ji-Hong Moon, Ju-Hee Lee, Uddin Md Nazim, Sang-Youel Park
Telmisartan broadly used for the treatment of hypertension that is also known for its anticancer properties. TRAIL has the potential to kill tumor cells with minimal toxicity in normal cells by binding to death receptors, DR4 and DR5. Unfortunately, these TRAIL-death receptors have failed as most human cancers are resistant to TRAIL-mediated apoptosis. In this study, we evaluated telmisartan as a novel TRAIL-DR5-targeting agent with the aim of rendering TRAIL-based cancer therapies more active. Herein, we demonstrated that telmisartan could sensitize TRAIL and enhance NSCLC tumor cell death...
June 18, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29928985/design-and-characterization-of-emulsified-spray-dried-alginate-microparticles-as-a-carrier-for-the-dually-acting-drug-roflumilast
#4
Azza A Mahmoud, Nermeen A Elkasabgy, Abdel Fatah A Abdelkhalek
Roflumilast is a selective inhibitor of phosphodiesterase-4 isoenzyme in lung cells. Having psychiatric adverse reactions when administered orally affects negatively the patients' adherence to the drug. This work aimed to prepare emulsified spray dried alginate microparticles for the pulmonary delivery of roflumilast. Sodium alginate was used as microparticle-forming material, isopropyl myristate as an oil, Tween®80 as surfactant and calcium beta-glycerophosphate as cross-linking agent to enhance the mechanical properties of the particles...
June 18, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29928970/gallic-acid-coated-sliver-nanoparticle-alters-the-expression-of-radiation-induced-epithelial-mesenchymal-transition-in-non-small-lung-cancer-cells
#5
S N Sunil Gowda, S Rajasowmiya, V Vadivel, S Banu Devi, A Celestin Jerald, S Marimuthu, N Devipriya
BACKGROUND: Radiotherapy is the most widely used treatment method for treating cancer with or without surgery and chemotherapy. In lung cancer, it is one of the important treatment steps in excising the tumor from the lung tissue; unfortunately, radiation can induce epithelial- mesenchymal transition (EMT), a typical physiological process in which cuboidal shaped epithelial cell loses its phenotype and acquires mesenchymal-like phenotype thus, increases the metastasis progression in the body...
June 18, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29928969/long-term-exposure-to-environmental-concentrations-of-diesel-exhaust-particles-does-not-impact-the-phenotype-of-human-bronchial-epithelial-cells
#6
Camille C Savary, Nessrine Bellamri, Claudie Morzadec, Sophie Langouët, Valérie Lecureur, Laurent Vernhet
Chronic exposure to diesel engine exhausts is associated with an increased risk of pulmonary diseases including lung cancer. Diesel engine exhausts contain large amounts of diesel exhaust particles (DEP) on which are adsorbed several carcinogenic compounds such as polycyclic aromatic hydrocarbons. Acute toxicity of high concentrations of DEP has been largely demonstrated in various in vitro cellular models. In contrast, the cellular and molecular impacts of low environmental concentrations of DEP on the phenotype of chronically exposed lung epithelial cells remain to be investigated...
June 18, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29928955/effects-of-different-durations-of-sustained-inflation-during-cardiopulmonary-resuscitation-on-return-of-spontaneous-circulation-and-hemodynamic-recovery-in-severely-asphyxiated-piglets
#7
J Mustofa, P-Y Cheung, S Patel, T F Lee, M Lu, M P Pasquin, M OʼReilly, G M Schmölzer
OBJECTIVE: We previously demonstrated that sustained inflation (SI) during chest compression (CC) significantly reduces time to return of spontaneous circulation (ROSC) when compared to 3:1 compression:ventilation (C:V) ratio during neonatal resuscitation. However, the optimal length of SI during CC to improve ROSC and hemodynamic recovery in severely asphyxiated piglets is unknown. AIM: To examine if different lengths of SI will improve ROSC and hemodynamic recovery in severely asphyxiated piglets...
June 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29928919/the-psychoactive-substance-of-cannabis-%C3%AE-9-tetrahydrocannabinol-thc-negatively-regulates-cftr-in-airway-cells
#8
Sheng-Wei Chang, Jack Wellmerling, Xiaoli Zhang, Rachael E Rayner, Wissam Osman, Sara Mertz, Amal O Amer, Mark E Peeples, Prosper N Boyaka, Estelle Cormet-Boyaka
BACKGROUND: Marijuana consumption is on the rise in the US but the health benefits of cannabis smoking are controversial and the impact of cannabis components on lung homeostasis is not well-understood. Lung function requires a fine regulation of the ion channel CFTR, which is responsible for fluid homeostasis and mucocilliary clearance. The goal of this study was to assess the effect that exposure to Δ9-tetrahydrocannabinol (THC), the psychoactive substance present in marijuana, has on CFTR expression and function...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29928911/cadm1-is-a-diagnostic-marker-in-early-stage-mycosis-fungoides-multicenter-study-of-58-cases
#9
Akihiko Yuki, Satoru Shinkuma, Ryota Hayashi, Hiroki Fujikawa, Taisuke Kato, Erina Homma, Yohei Hamade, Osamu Onodera, Masao Matsuoka, Hiroshi Shimizu, Hiroaki Iwata, Riichiro Abe
BACKGROUND: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 (CADM1), initially identified as a tumor suppressor gene in human non-small-cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma (ATLL). OBJECTIVE: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF...
June 18, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29928883/suppression-of-cleavage-factor-im-25-promotes-the-proliferation-of-lung-cancer-cells-through-alternative-polyadenylation
#10
Jingjing Huang, Tingting Weng, Junsuk Ko, Ning-Yuan Chen, Yu Xiang, Kelly Volcik, Leng Han, Michael R Blackburn, Xiang Lu
BACKGROUND: Non-small cell lung cancer (NSCLC) is a life-threatening disease that has a poor prognosis and low survival rate. Cleavage factor Im 25 (CFIm25) is a RNA-binding protein that if down-regulated causes 3'UTR shortening and thus promotes the transcript stability of target genes. It is not clear whether CFIm25 and alternative polyadenylation (APA) play a role during cancer development. The purpose of this study is to explore the role of CFIm25 in lung cancer cell proliferation...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928852/oxygen-use-after-lung-cancer-surgery
#11
Daniel G Nicastri, Naomi Alpert, Bian Liu, Andrea Wolf, Emanuela Taioli, Benjamin V Tran, Raja Flores
BACKGROUND: There are no published reports on predictors of oxygen (O2 ) use after lung cancer surgery. The prospect of O2 use following lung cancer surgery may affect a patient's therapy choice. METHODS: The Surveillance, Epidemiology, and End Results -Medicare (SEER-Medicare) dataset was queried to identify patients diagnosed with primary lung cancer (stage I/II) who underwent surgical resection from 1994-2010. Patients with a second resection within 6 months of their first and those with preoperative O2 use were excluded...
June 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29928824/enrichment-of-innate-lymphoid-cell-populations-in-gingival-tissue
#12
J L Brown, L Campbell, J Malcolm, A Adrados Planell, J P Butcher, S Culshaw
Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual subsets of ILCs in the oral tissues. We sought to investigate the whole ILC population (group 1, 2, and 3 subsets) in the murine gingivae and the lymph nodes draining the oral cavity. We show that ILCs made up a greater proportion of the whole CD45+ lymphocyte population in the murine gingivae (0...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29928807/prevalence-and-determinants-of-smoking-and-secondhand-smoke-exposure-in-a-rural-population-of-central-greece-a-cross-sectional-study
#13
Chrysovalantis Stafylis, George Rachiotis, Antonis Katsioulis, Varvara A Mouchtouri, Christos Hadjichristodoulou
INTRODUCTION: Smoking is one of the most important risk factors for heart and lung disease and is responsible for many forms of cancer. The resulting morbidity and mortality weigh heavily upon countries with high prevalence, such as Greece. According to the Global Adult Tobacco Survey (GATS) Greece, 38.2% of Greeks aged ≥15 years, namely 51.2% of men and 25.7% of women, are smokers. Smoking is also common among the young and people of high education. Despite laws prohibiting smoking at indoor places, exposure to environmental tobacco is very high both in private and public places...
June 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29928803/discovery-of-n-4-quinolin-4-yloxy-phenyl-benzenesulfonamides-as-novel-axl-kinase-inhibitors
#14
István Szabadkai, Robert Torka, Rita Garamvölgyi, Ferenc Baska, Pál Gyulavári, Sándor Boros, Eszter Illyés, Axel Choidas, Axel Ullrich, László Őrfi
The overexpression of AXL kinase has been described in many types of cancer. Due to its role in proliferation, survival, migration and resistance AXL represents a promising target in the treatment of the disease. In this study we present a novel compound family which successfully targets the AXL kinase. Through optimization and detailed SAR studies we developed low nanomolar inhibitors and after further biological characterization we identified a selective and applicable AXL kinase inhibitor with favorable pharmacokinetic profile...
June 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29928786/antitumor-perspectives-of-oleuropein-and-its-metabolite-hydroxytyrosol-recent-updates
#15
REVIEW
Muhammad Imran, Muhammad Nadeem, Syed Amir Gilani, Shaista Khan, Muhammad Wasim Sajid, Rai Muhammad Amir
Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis...
June 21, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29928768/high-altitude-trekking-after-lung-transplantation-a-prospective-study-using-lung-ultrasound-to-detect-comets-tails-for-interstital-pulmonary-edema-in-lung-transplant-recipients-and-healthy-volunteers
#16
Ulrike Weber, Judith Schiefer, Jakob Mühlbacher, Martin Hermann Bernardi, Clemens Maria Ortner, Peter Jaksch
The intensity of physical activity which can be tolerated after lung transplantation and the tolerance to prolonged exercise at high altitude are poorly investigated. Lung ultrasound comet tails have been used in the diagnosis of interstitial pulmonary edema and high pulmonary altitude edema. The aim was to asses the number of lung ultrasound comet tails and to monitor changes in the optic nerve sheath diameter (ONSD) during a climb to the top of Mount Kilimanjaro in 10 lung transplant recipients and 10 healthy controls at three different altitude levels: 1360m, 3505m, 4900m...
June 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29928698/maternal-exercise-training-attenuates-endotoxin-induced-sepsis-in-mice-offspring
#17
Mami Yamada, Chihiro Hokazono, Mitsuharu Okutsu
Regular exercise during pregnancy can prevent offspring from several diseases, such as cardiovascular diseases, obesity, and type II diabetes during adulthood. However, little information is available about whether maternal exercises during pregnancy protect the offspring from infectious diseases, such as sepsis and multiple organ dysfunction syndrome (MODS). This study aimed to investigate whether maternal exercise training protects the offspring from endotoxin-induced septic shock in mice. Female C57BL/6 mice performed voluntary wheel exercises during pregnancy...
September 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29928522/relevance-of-nutritional-support-and-early-rehabilitation-in-hospitalized-patients-with-copd
#18
REVIEW
Ghislaine Gayan-Ramirez
Exacerbation of COPD is associated with a worsening of lung function and symptoms, and a serious loss in functional status and health related quality of life. It also represents the major cause for emergency hospitalization in COPD patients which places the patient at risk for developing further muscle weakness. Actually, loss of muscle function developed fast and continued to decrease over time during hospitalization and may be further compromised when disease deterioration would require the use of ventilator support...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928519/can-muscle-protein-metabolism-be-specifically-targeted-by-exercise-training-in-copd
#19
REVIEW
Davina C M Simoes, Ioannis Vogiatzis
Patients with stable chronic obstructive pulmonary disease (COPD) frequently exhibit unintentional accentuated peripheral muscle loss and dysfunction. Skeletal muscle mass in these patients is a strong independent predictor of morbidity and mortality. Factors including protein anabolism/catabolism imbalance, hypoxia, physical inactivity, inflammation, and oxidative stress are involved in the initiation and progression of muscle wasting in these patients. Exercise training remains the most powerful intervention for reversing, in part, muscle wasting in COPD...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928517/nutritional-status-and-muscle-dysfunction-in-chronic-respiratory-diseases-stable-phase-versus-acute-exacerbations
#20
REVIEW
Joaquim Gea, Antoni Sancho-Muñoz, Roberto Chalela
Nutritional abnormalities are frequent in different chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), interstitial fibrosis and lung cancer, having important clinical consequences. However, nutritional abnormalities often remained underdiagnosed due to the relative lack of awareness of health professionals. Therefore, systematic anthropometry or even better, assessment of body composition, should be performed in all patients with chronic respiratory conditions, especially following exacerbation periods when malnutrition becomes more accentuated...
May 2018: Journal of Thoracic Disease
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