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Tumor budding

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https://www.readbyqxmd.com/read/28505009/a-novel-grading-system-based-on-tumor-budding-and-cell-nest-size-is-a-strong-predictor-of-patient-outcome-in-esophageal-squamous-cell-carcinoma
#1
Moritz Jesinghaus, Melanie Boxberg, Björn Konukiewitz, Julia Slotta-Huspenina, Anna M Schlitter, Katja Steiger, Katja Specht, Kathrin Wieczorek, Arne Warth, Thomas Schmidt, Arndt Hartmann, Ihsan E Demir, Markus Feith, Katja Ott, Wilko Weichert
The determination of prognosis in patients with esophageal squamous cell carcinoma (ESCC) is primarily based on staging according to the TNM-classification, whereas conventional grading is of minor clinical importance because of its deficiencies in prognostic patient stratification. Recently, a novel, highly prognostic grading scheme based on budding activity and cell nest size has been proposed for squamous cell carcinoma (SCC) of both pulmonary as well as oral origin. In order to investigate the utility and transferability of this approach to ESCC, we evaluated budding activity and cell nest size, as well as other histomorphologic characteristics, in a cohort of 135 primarily resected tumors and correlated the results with clinicopathologic and outcome parameters...
May 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28498282/tumor-spread-through-air-spaces-is-an-independent-predictor-of-recurrence-free-survival-in-patients-with-resected-lung-squamous-cell-carcinoma
#2
Kyuichi Kadota, Yoshio Kushida, Naomi Katsuki, Ryou Ishikawa, Emi Ibuki, Mutsumi Motoyama, Kazuhito Nii, Hiroyasu Yokomise, Shuji Bandoh, Reiji Haba
Tumor spread through air spaces (STAS) is a newly recognized pattern of invasion in lung adenocarcinoma. However, clinical significance of STAS has not yet been characterized in lung squamous cell carcinoma. In this study, we investigated whether STAS could determine clinical outcome in Japanese patients with lung squamous cell carcinoma. We reviewed tumor slides from surgically resected lung squamous cell carcinomas (n=216). STAS was defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor...
May 11, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28477021/transgenic-overexpression-of-nanogp8-in-the-mouse-prostate-is-insufficient-to-initiate-tumorigenesis-but-weakly-promotes-tumor-development-in-the-hi-myc-mouse-model
#3
Bigang Liu, Shuai Gong, Qiuhui Li, Xin Chen, John Moore, Mahipal V Suraneni, Mark D Badeaux, Collene R Jeter, Jianjun Shen, Rashid Mehmood, Qingxia Fan, Dean G Tang
This project was undertaken to address a critical cancer biology question: Is overexpression of the pluripotency molecule Nanog sufficient to initiate tumor development in a somatic tissue? Nanog1 is critical for the self-renewal and pluripotency of ES cells, and its retrotransposed homolog, NanogP8 is preferentially expressed in somatic cancer cells. Our work has shown that shRNA-mediated knockdown of NanogP8 in prostate, breast, and colon cancer cells inhibits tumor regeneration whereas inducible overexpression of NanogP8 promotes cancer stem cell phenotypes and properties...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28475002/form-follows-function-morphological-and-immunohistological-insights-into-epithelial-mesenchymal-transition-characteristics-of-tumor-buds
#4
Kathrin Enderle-Ammour, Moritz Bader, Theresa Dorothee Ahrens, Kai Franke, Sylvia Timme, Agnes Csanadi, Jens Hoeppner, Birte Kulemann, Jochen Maurer, Philip Reiss, Oliver Schilling, Tobias Keck, Thomas Brabletz, Elmar Stickeler, Martin Werner, Ulrich Friedrich Wellner, Peter Bronsert
In cancer biology, the architectural concept "form follows function" is reflected by cell morphology, migration, and epithelial-mesenchymal transition protein pattern. In vivo, features of epithelial-mesenchymal transition have been associated with tumor budding, which correlates significantly with patient outcome. Hereby, the majority of tumor buds are not truly detached but still connected to a major tumor mass. For detailed insights into the different tumor bud types and the process of tumor budding, we quantified tumor cells according to histomorphological and immunohistological epithelial-mesenchymal transition characteristics...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28451002/-costal-metastasis-revealing-esophageal-squamous-cell-carcinoma
#5
Mamadou Ngoné Gueye, Gnagna Diouf, Daouda Dia, Awa Boye, Thierno Fall, Jean Louis Diémé, Oumar Ba, Mouhamadou Mbengue
Esophageal cancer is associated with poor prognosis. Its severity is linked to delayed diagnosis which is most often made once a cancer has metastasized, in Africa. Costal metastases are rare. We report a case of a 38-year old Senegalese patient with squamous cell carcinoma of the lower esophagus with lytic metastases to the ribs. Mrs. TD, aged 38, was admitted with painful swelling in right hemithorax associated with weight loss. The patient also reported mechanical dysphagia evolving during 4 months which had not motivated consultation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28442513/histopathological-significance-and-prognostic-impact-of-tumor-budding-in-colorectal-cancer
#6
Anurag Mehta, Malini Goswami, Rupal Sinha
BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease with complex etiology. New prognostic factors for this group of disease need to be investigated. This study evaluated the histopathological significance and prognostic impact of tumor budding in CRC. DESIGN: A total of 60 treatment naive consecutive patients undergoing surgical resection for CRC during the period of January 2011 to December 2013 were included in the study. Details of each patient related to their demographic and tumor profile were recorded...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28438617/tumor-budding-as-a-risk-factor-for-nodal-metastasis-in-pt1-colorectal-cancers-a-meta-analysis
#7
Rocco Cappellesso, Claudio Luchini, Nicola Veronese, Marcello Lo Mele, Erik Rosa-Rizzotto, Ennio Guido, Franca De Lazzari, Pierluigi Pilati, Fabio Farinati, Stefano Realdon, Marco Solmi, Matteo Fassan, Massimo Rugge
Worldwide, colorectal cancer (CRC) screening programs have significantly increased the detection of sub-mucosal (pT1) adenocarcinoma. Completion surgery may be indicated after endoscopic excision of these potentially metastasizing early cancers. However, the post-surgical prevalence of nodal implants does not exceed 15%, leading to questions concerning the clinical appropriateness of any post-endoscopy surgery. Eastern scientific societies (Japanese Society for Cancer of the Colon-Rectum, in particular) include tumor budding (TB), defined as the presence of isolated single cancer cells or clusters of fewer than five cancer cells at the tumor invasive front, among the variables that must be included in histological reports...
April 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28436947/dedifferentiation-into-blastomere-like-cancer-stem-cells-via-formation-of-polyploid-giant-cancer-cells
#8
N Niu, I Mercado-Uribe, J Liu
Our recent perplexing findings that polyploid giant cancer cells (PGCCs) acquired embryonic-like stemness and were capable of tumor initiation raised two important unanswered questions: how do PGCCs acquire such stemness, and to which stage of normal development do PGCCs correspond. Intriguingly, formation of giant cells due to failed mitosis/cytokinesis is common in the blastomere stage of the preimplantation embryo. However, the relationship between PGCCs and giant blastomeres has never been studied. Here, we tracked the fate of single PGCCs following paclitaxel-induced mitotic failure...
April 24, 2017: Oncogene
https://www.readbyqxmd.com/read/28428104/tumor-budding-in-intestinal-type-gastric-adenocarcinoma-is-associated-with-nodal-metastasis-and-recurrence
#9
Stephen Olsen, Jin Linda, Ryan C Fields, Yan Yan, ILKe Nalbantoglu
Gastric adenocarcinoma (GAC) is a common cause of cancer-related death worldwide. GAC can be classified as intestinal or diffuse. Intestinal type cancers are common and reported to have a better prognosis compared to diffuse cancers. Studies have shown the presence and amount of tumor budding in intestinal carcinomas of the colon and esophagus to predict nodal metastasis and recurrence. Our aim is to determine if tumor budding in intestinal type GAC correlates with prognostic features. One hundred four patients treated with primary surgical excision between 1999-2013 were identified...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28416958/keratinization-of-lung-squamous-cell-carcinoma-is-associated-with-poor-clinical-outcome
#10
Hye Jung Park, Yoon-Jin Cha, Seong Han Kim, Arum Kim, Eun Young Kim, Yoon Soo Chang
BACKGROUND: Although the World Health Organization (WHO) classification of lung squamous cell carcinoma (SCC) was revised in 2015, its clinical implications for lung SCC subsets remain unclear. We investigated whether the morphologic characteristics of lung SCC, including keratinization, were associated with clinical parameters and clinical outcome of patients. METHODS: A total of 81 patients who underwent curative surgical resection of diagnosed lung SCC, were enrolled in this study...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28415608/collagen-type-iv-alpha-1-col4a1-and-collagen-type-xiii-alpha-1-col13a1-produced-in-cancer-cells-promote-tumor-budding-at-the-invasion-front-in-human-urothelial-carcinoma-of-the-bladder
#11
Makito Miyake, Shunta Hori, Yosuke Morizawa, Yoshihiro Tatsumi, Michihiro Toritsuka, Sayuri Ohnishi, Keiji Shimada, Hideki Furuya, Vedbar S Khadka, Youping Deng, Kenta Ohnishi, Kota Iida, Daisuke Gotoh, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Noboru Konishi, Kiyohide Fujimoto
Current knowledge of the molecular mechanism driving tumor budding is limited. Here, we focused on elucidating the detailed mechanism underlying tumor budding in urothelial cancer of the bladder. Invasive urothelial cancer was pathologically classified into three groups as follows: nodular, trabecular, and infiltrative (tumor budding). Pathohistological analysis of the orthotopic tumor model revealed that human urothelial cancer cell lines MGH-U3, UM-UC-14, and UM-UC-3 displayed typical nodular, trabecular, and infiltrative patterns, respectively...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407700/correction-dapk-loss-in-colon-cancer-tumor-buds-implications-for-migration-capacity-of-disseminating-tumor-cells
#12
Jelena Ivanovska, Inti Zlobec, Stefan Forster, Eva Karamitopoulou, Heather Dawson, Viktor Hendrik Koelzer, Abbas Agaimy, Fabian Garreis, Stephan Söder, William Laqua, Alessandro Lugli, Arndt Hartmann, Tilman T Rau, Regine Schneider-Stock
No abstract text is available yet for this article.
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407462/overexpression-of-postn-in-tumor-stroma-is-a-poor-prognostic-indicator-of-colorectal-cancer
#13
Hyeon Jeong Oh, Jeong Mo Bae, Xian-Yu Wen, Nam-Yun Cho, Jung Ho Kim, Gyeong Hoon Kang
BACKGROUND: Tumor microenvironment has recently drawn attention in that it is related with tumor prognosis. Cancer-associated fibroblast also plays a critical role in cancer invasiveness and progression in colorectal cancers. Periostin (POSTN), originally identified to be expressed in osteoblasts and osteoblast-derived cells, is expressed in cancer-associated fibroblasts in several tissue types of cancer. Recent studies suggest an association between stromal overexpression of POSTN and poor prognosis of cancer patients...
May 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28402788/ustilago-maydis-the-corn-smut-fungus-has-an-unusual-diploid-mitotic-stage
#14
Karen Snetselaar, Michael McCann
Ustilago maydis causes common smut disease in maize. Although pathogenic diploid strains of the fungus have been known for many years, the normal life cycle was thought to involve an extended dikaryotic stage, with nuclear fusion occurring in immature teliospores. However, microscopic examination of both living and fixed tumor material showed that nuclei fuse long before sporulation begins and that tumors are filled with uninucleate cells undergoing mitosis. Quantification of DNA in the nuclei confirmed these observations...
2017: Mycologia
https://www.readbyqxmd.com/read/28391172/large-bronchogenic-cyst-of-stomach-a-case-report
#15
Amine Chhaidar, Houssem Ammar, Nihed Abdessayed, Mohamed Azzaza, Rahul Gupta, Nefis Abdennaceur, Ahlem Bdioui, Moncef Mokni, Ali Ben Ali
INTRODUCTION: Bronchogenic cysts are congenital cysts arising as an abnormal budding from primitive tracheobronchial tree. They are lined by pseudostratified columnar or cuboidal ciliated epithelium and contain smooth muscle fibers, submucosal bronchial glands and/or cartilage. They are most frequently located in the mediastinum or the lung parenchyma. Intramural occurrence of bronchogenic cyst in the gastric wall is very rare. PRESENTATION OF CASE: We present a case of 65-year-old lady with a 7×8cm lesion in the gastric cardia suspicious of gastrointestinal stromal tumor...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28383823/reproducibility-repeatability-and-level-of-difficulty-of-two-methods-for-tumor-budding-evaluation-in-oral-squamous-cell-carcinoma
#16
Priscila Laiza Rubim Leão, Helvécio Marangon Junior, Victória Vasconcellos Moreira Melo, Ângela Braga Caixeta, Paulo Eduardo Alencar Souza, Maria Cássia Ferreira de Aguiar, Martinho Campolina Rebello Horta
BACKGROUND: This study aimed to analyze the reproducibility, repeatability and level of difficulty of two methods for tumor budding evaluation in oral squamous cell carcinoma (OSCC): staining by hematoxylin and eosin (HE), and immunostaining for multi-cytokeratin. METHODS: The evaluation of tumor budding was performed by three examiners in 103 samples of OSCC, using the two methods. A Likert-type scale was used to measure the difficulty in the assessment. The inter-examiner agreement (reproducibility) was estimated using Fleiss's Kappa and the intra-examiner agreement (repeatability) was estimated using Cohen's Kappa...
April 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28374102/predictive-significance-of-tumor-depth-and-budding-for-late-lymph-node-metastases-in-patients-with-clinical-n0-early-oral-tongue-carcinoma
#17
Yukiko Hori, Akira Kubota, Tomoyuki Yokose, Madoka Furukawa, Takeshi Matsushita, Morihito Takita, Sachiyo Mitsunaga, Nobutaka Mizoguchi, Tetsuo Nonaka, Yuko Nakayama, Nobuhiko Oridate
In clinical N0 early oral tongue carcinoma, treatment of occult lymph node metastasis is controversial. The purpose of this study was to assess the histopathological risk factors for predicting late lymph node metastasis in early oral tongue carcinoma. We retrospectively reviewed 48 patients with early oral tongue squamous cell carcinoma. Associations between the histopathological factors (depth of tumor, differentiation, blood vessel invasion, lymphatic invasion, and tumor budding) and late lymph metastasis were analyzed...
April 3, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28356962/comparative-clinicopathological-characteristics-of-colon-and-rectal-t1-carcinoma
#18
Katsuro Ichimasa, Shin-Ei Kudo, Hideyuki Miyachi, Yuta Kouyama, Takemasa Hayashi, Kunihiko Wakamura, Tomokazu Hisayuki, Toyoki Kudo, Masashi Misawa, Yuichi Mori, Shingo Matsudaira, Eiji Hidaka, Shigeharu Hamatani, Fumio Ishida
Lymph node metastasis significantly influences the management of patients with colorectal carcinoma. It has been observed that the biology of colorectal carcinoma differs by location. The aim of the current study was to retrospectively compare the clinicopathological characteristics of patients with colon and rectal T1 carcinomas, particularly their rates of lymph node metastasis. Of the 19,864 patients who underwent endoscopic or surgical resection of colorectal neoplasms at Showa University Northern Yokohama Hospital, 557 had T1 surgically resected carcinomas, including 457 patients with colon T1 carcinomas and 100 patients with rectal T1 carcinomas...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28346327/development-of-a-new-outcome-prediction-model-in-early-stage-squamous-cell-carcinoma-of-the-oral-cavity-based-on-histopathologic-parameters-with-multivariate-analysis-the-aditi-nuzhat-lymph-node-prediction-score-anlps-system
#19
Aditi Arora, Nuzhat Husain, Ankur Bansal, Azfar Neyaz, Ritika Jaiswal, Kavitha Jain, Arun Chaturvedi, Nidhi Anand, Kiranpreet Malhotra, Saumya Shukla
The aim of this study was to evaluate the histopathologic parameters that predict lymph node metastasis in patients with oral squamous cell carcinoma (OSCC) and to design a new assessment score on the basis of these parameters that could ultimately allow for changes in treatment decisions or aid clinicians in deciding whether there is a need for close follow-up or to perform early lymph node dissection. Histopathologic parameters of 336 cases of OSCC with stage cT1/T2 N0M0 disease were analyzed. The location of the tumor and the type of surgery used for the management of the tumor were recorded for all patients...
March 24, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28323169/isolation-and-characterization-of-human-capg-expressed-and-post-translationally-modified-in-pichia-pastoris
#20
Agnes Papala, Marc Sylvester, Nadine Dyballa-Rukes, Sabine Metzger, Jochen D'Haese
CapG is an actin-binding protein, which is overexpressed in a variety of tumors, i.e. breast, ovarian, pancreatic and lung carcinoma. We successfully expressed human CapG in the wild type strain X-33 of the methylotrophic yeast Pichia pastoris (P. pastoris), which does not express endogenous CapG, in order to characterize this protein in more detail. After mechanical cell lysis, debris was centrifuged and the soluble protein was precipitated with ammonium sulfate. This protein pellet was dialyzed and used for CapG purification...
March 18, 2017: Protein Expression and Purification
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