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https://www.readbyqxmd.com/read/27902593/angiosarcoma-in-the-chest-radiologic-pathologic-correlation-case-report
#1
Sara Piciucchi, Alessandra Dubini, Sara Tomassetti, Stefano Sanna, Claudia Ravaglia, Angelo Carloni, Christian Gurioli, Carlo Gurioli, Thomas V Colby, Venerino Poletti
RATIONALE: Angiosarcomas are rare, malignant vascular tumors. PATIENT CONCERNS: They represents about 2% of all soft tissue sarcoma, which can often metastasize through the hematogenous route. The radiological features have been analyzed in 4 patients with metastatic angiosarcoma in the chest. DIAGNOSES: The main radiologic findings included nodules, cysts, nodules with halo sign, and vascular tree-in-bud. Morphologic features, as observed in the histologic specimen, have been correlated with radiologic appearance...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27875985/nuclear-envelope-structural-defect-underlies-the-main-cause-of-aneuploidy-in-ovarian-carcinogenesis
#2
Callinice D Capo-Chichi, Toni M Yeasky, Elizabeth R Smith, Xiang-Xi Xu
BACKGROUND: The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is extensive aneuploidy caused by chromosomal numerical instability, which is thought to promote malignant transformation. Conventionally, aneuploidy is thought to be the result of mitotic errors and chromosomal nondisjunction during mitosis. Previously, we found that ovarian cancer cells often lost or reduced nuclear lamina proteins lamin A/C, and suppression of lamin A/C in cultured ovarian epithelial cells leads to aneuploidy...
November 22, 2016: BMC Cell Biology
https://www.readbyqxmd.com/read/27869652/epithelial-to-mesenchymal-transition-drives-a-pro-metastatic-golgi-compaction-process-through-scaffolding-protein-paqr11
#3
Xiaochao Tan, Priyam Banerjee, Hou-Fu Guo, Stephen Ireland, Daniela Pankova, Young-Ho Ahn, Irodotos Michail Nikolaidis, Xin Liu, Yanbin Zhao, Yongming Xue, Alan R Burns, Jonathon Roybal, Don L Gibbons, Tomasz Zal, Chad J Creighton, Daniel Ungar, Yanzhuang Wang, Jonathan M Kurie
Tumor cells gain metastatic capacity through a Golgi phosphoprotein 3-dependent (GOLPH3-dependent) Golgi membrane dispersal process that drives the budding and transport of secretory vesicles. Whether Golgi dispersal underlies the pro-metastatic vesicular trafficking that is associated with epithelial-to-mesenchymal transition (EMT) remains unclear. Here, we have shown that, rather than causing Golgi dispersal, EMT led to the formation of compact Golgi organelles with improved ribbon linking and cisternal stacking...
November 21, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27866426/comparative-study-on-the-induction-of-complex-genomic-alterations-after-exposure-of-mammalian-cells-to-carboplatin-and-oxaliplatin
#4
Ana Paula de Souza, Mauricio Lehmann, Rafael Rodrigues Dihl
Metal complexes are still broadly used as the first line of the treatment for different types of tumors nowadays. Carboplatin and oxaliplatin were authorized for clinical use, even though there is little information on the mutagenic profile associated to their usage. This study evaluated the cytostatic effects and the induction of complex genomic alterations after 24-h treatment of CHO-K1 cells to concentrations of 12.5-800 μM of carboplatin and oxaliplatin in the cytokinesis-block micronucleus assay (CBMN-Cyt)...
November 20, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27861522/high-grade-tumor-budding-stratifies-early-stage-cervical-cancer-with-recurrence-risk
#5
Bangxing Huang, Jing Cai, Xia Xu, Shuang Guo, Zehua Wang
OBJECTIVES: This study investigated prognostic significance of tumor budding in early-stage cervical cancer (ESCC) following radical surgery and its contribution to improve the stratification of patients with recurrence risk. METHODS: The archival medical records and H&E-stained slides of 643 patients with IA2-IIA stage cervical cancer who underwent radical surgery were retrospectively reviewed. Clinicopathological parameters were noted, and tumor buds were counted using immunohistochemistry for each case...
2016: PloS One
https://www.readbyqxmd.com/read/27843459/tumor-budding-micropapillary-pattern-and-polyploidy-giant-cancer-cells-in-colorectal-cancer-current-status-and-future-prospects
#6
REVIEW
Shiwu Zhang, Dan Zhang, Zhengduo Yang, Xipeng Zhang
We previously reported that polyploid giant cancer cells (PGCGs) induced by CoCl2 could form through endoreduplication or cell fusion. A single PGCC formed tumors in immunodeficient mice. PGCCs are also the key contributors to the cellular atypia and associate with the malignant grade of tumors. PGCCs have the properties of cancer stem cells and produce daughter cells via asymmetric cell division. Compared with diploid cancer cells, these daughter cells express less epithelial markers and acquire mesenchymal phenotype with importance in cancer development and progression...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27836787/tumor-budding-at-the-invasive-front-of-colorectal-cancer-may-not-be-associated-with-the-epithelial-mesenchymal-transition
#7
Noriyuki Yamada, Tamotsu Sugai, Makoto Eizuka, Koudai Tsuchida, Ryo Sugimoto, Yoshiharu Mue, Masamichi Suzuki, Mitsumasa Osakabe, Noriyuki Uesugi, Kazuyuki Ishida, Kouki Otsuka, Takayuki Matsumoto
Tumor budding is thought to reflect the epithelial-mesenchymal transition (EMT). However, the molecular mechanism linking tumor buds and the EMT remains unclear. Here, we examined the induction of tumor budding and EMT and their association with EMT-related proteins (ZEB1, TWIST, SNAIL and SLUG) in colorectal cancer (CRC). Immunohistochemical expression of pan-cytokeratin was examined for identification of tumor budding in 101 CRCs. Grading of tumor budding was classified into low and high grade groups. Tissue micro-array was conducted to identify tumor budding sites...
November 8, 2016: Human Pathology
https://www.readbyqxmd.com/read/27833910/extracellular-microvesicle-production-by-human-eosinophils-activated-by-inflammatory-stimuli
#8
Praveen Akuthota, Lívia A S Carmo, Kennedy Bonjour, Ryann O Murphy, Thiago P Silva, Juliana P Gamalier, Kelsey L Capron, John Tigges, Vasilis Toxavidis, Virginia Camacho, Ionita Ghiran, Shigeharu Ueki, Peter F Weller, Rossana C N Melo
A key function of human eosinophils is to secrete cytokines, chemokines and cationic proteins, trafficking, and releasing these mediators for roles in inflammation and other immune responses. Eosinophil activation leads to secretion of pre-synthesized granule-stored mediators through different mechanisms, but the ability of eosinophils to secrete extracellular vesicles (EVs), very small vesicles with preserved membrane topology, is still poorly understood. In the present work, we sought to identify and characterize EVs released from human eosinophils during different conditions: after a culturing period or after isolation and stimulation with inflammatory stimuli, which are known to induce eosinophil activation and secretion: CCL11 (eotaxin-1) and tumor necrosis factor alpha (TNF-α)...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27826198/high-expression-of-muscarinic-acetylcholine-receptor-3-predicts-poor-prognosis-in-patients-with-pancreatic-ductal-adenocarcinoma
#9
Lingfu Zhang, Dianrong Xiu, Jun Zhan, Xiaokun He, Limei Guo, Jilian Wang, Ming Tao, Wei Fu, Hongquan Zhang
AIMS: Recent studies showed that muscarinic acetylcholine receptor 3 (M3), as a muscarinic acetylcholine receptor family member that plays an important role in normal physiological function, is engaged in cancer progression. However, the role of M3 in pancreatic ductal adenocarcinoma (PDAC) is not known. The aim of this study is to investigate the expression and prognostic value of M3 in patients with PDAC. MATERIALS AND METHODS: The localization and expression of M3 in PDAC were examined by immunohistochemistry...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27825542/histopathological-tumor-invasion-of-the-mesenterico-portal-vein-is-characterized-by-aggressive-biology-and-stromal-fibroblast-activation
#10
Hryhoriy Lapshyn, Louisa Bolm, Ilona Kohler, Martin Werner, Franck G Billmann, Dirk Bausch, Ulrich T Hopt, Frank Makowiec, Uwe A Wittel, Tobias Keck, Peter Bronsert, Ulrich F Wellner
BACKGROUND: Mesenterico-portal vein resection (PVR) during pancreatoduodenectomy for pancreatic head cancer was established in the 1990s and can be considered a routine procedure in specialized centers today. True histopathologic portal vein invasion is predictive of poor prognosis. The aim of this study was to examine the relationship between mesenterico-portal venous tumor infiltration (PVI) and features of aggressive tumor biology. METHODS: Patients receiving PVR for pancreatic ductal adenocarcinoma of the pancreatic head were identified from a prospectively maintained database...
November 5, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27805003/image-analysis-derived-metrics-of-histomorphological-complexity-predicts-prognosis-and-treatment-response-in-stage-ii-iii-colon-cancer
#11
Artur Mezheyeuski, Ina Hrynchyk, Mia Karlberg, Anna Portyanko, Lars Egevad, Peter Ragnhammar, David Edler, Bengt Glimelius, Arne Östman
The complexity of tumor histomorphology reflects underlying tumor biology impacting on natural course and response to treatment. This study presents a method of computer-aided analysis of tissue sections, relying on multifractal (MF) analyses, of cytokeratin-stained tumor sections which quantitatively evaluates of the morphological complexity of the tumor-stroma interface. This approach was applied to colon cancer collection, from an adjuvant treatment randomized study. Metrics obtained with the method acted as independent markers for natural course of the disease, and for benefit of adjuvant treatment...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793046/transcriptional-upregulation-of-c-met-is-associated-with-invasion-and-tumor-budding-in-colorectal-cancer
#12
Conor A Bradley, Philip D Dunne, Victoria Bingham, Stephen McQuaid, Hajrah Khawaja, Stephanie Craig, Jackie James, Wendy L Moore, Darragh G McArt, Mark Lawler, Sonali Dasgupta, Patrick G Johnston, Sandra Van Schaeybroeck
c-MET and its ligand HGF are frequently overexpressed in colorectal cancer (CRC) and increased c-MET levels are found in CRC liver metastases. This study investigated the role of the HGF/c-MET axis in regulating migration/invasion in CRC, using pre-clinical models and clinical samples. Pre-clinically, we found marked upregulation of c-MET at both protein and mRNA levels in several invasive CRC cells. Down-regulation of c-MET using RNAi suppressed migration/invasion of parental and invasive CRC cells. Stimulation of CRC cells with rh-HGF or co-culture with HGF-expressing colonic myofibroblasts, resulted in significant increases in their migratory/invasive capacity...
October 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27737535/clinicopathologic-characteristics-and-prognosis-of-tongue-squamous-cell-carcinoma-in-patients-with-and-without-a-history-of-radiation-for-nasopharyngeal-carcinoma-a-matched-case-control-study
#13
Peng Zhang, Li Zhang, Hui Liu, Lei Zhao, Yong Li, Jing-Xian Shen, Qing Liu, Meng-Zhong Liu, Mian Xi
Purpose: Previous studies reported an association between an increased risk of tongue cancer and radiation treatment for nasopharyngeal carcinoma (NPC). This study compared the clinicopathologic characteristics and outcomes of tongue squamous cell carcinoma (TSCC) in patients with and without a history of radiotherapy for NPC. Materials and Methods: From 1965 to 2009, a total of 73 patients were diagnosed with TSCC with a history of radiotherapy for NPC. The patients were matched in a 1:3 ratio with patients with sporadic TSCC according to age, sex, and year of the TSCC diagnosis...
October 11, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27713423/downregulation-of-acetyl-coa-synthetase-2-is-a-metabolic-hallmark-of-tumor-progression-and-aggressiveness-in-colorectal-carcinoma
#14
Jeong Mo Bae, Jung Ho Kim, Hyeon Jeong Oh, Hye Eun Park, Tae Hun Lee, Nam-Yun Cho, Gyeong Hoon Kang
Acetyl-CoA synthetase-2 is an emerging key enzyme for cancer metabolism, which supplies acetyl-CoA for tumor cells by capturing acetate as a carbon source under stressed conditions. However, implications of acetyl-CoA synthetase-2 in colorectal carcinoma may differ from other malignancies, because normal colonocytes use short-chain fatty acids as an energy source, which are supplied by fermentation of the intestinal flora. Here we analyzed acetyl-CoA synthetase-2 mRNA expression by reverse-transcription quantitative PCR in paired normal mucosa and tumor tissues of 12 colorectal carcinomas, and subsequently evaluated acetyl-CoA synthetase-2 protein expression by immunohistochemistry in 157 premalignant colorectal lesions, including 60 conventional adenomas and 97 serrated polyps, 1,106 surgically resected primary colorectal carcinomas, and 23 metastatic colorectal carcinomas in the liver...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27713420/colorectal-carcinomas-with-submucosal-invasion-pt1-analysis-of-histopathological-and-molecular-factors-predicting-lymph-node-metastasis
#15
Reetesh K Pai, Yuwei Chen, Maureen A Jakubowski, Bonnie L Shadrach, Thomas P Plesec, Rish K Pai
Submucosally invasive colorectal carcinoma (pT1) has the potential to be cured by local excision. In US surgical intervention is reserved for tumors with high-grade morphology, lymphvascular invasion, and close/positive margin. In other countries, particularly Japan, surgical therapy is also recommended for mucinous tumors, tumors with >1000 μm of submucosal invasion, and those with high tumor budding. These histological features have not been well evaluated in a western cohort of pT1 carcinomas. In a cohort of 116 surgically resected pT1 colorectal carcinomas, high tumor budding (P<0...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27711225/keratin-13-is-enriched-in-prostate-tubule-initiating-cells-and-may-identify-primary-prostate-tumors-that-metastasize-to-the-bone
#16
Sandy Liu, Radu M Cadaneanu, Baohui Zhang, Lihong Huo, Kevin Lai, Xinmin Li, Colette Galet, Tristan R Grogan, David Elashoff, Stephen J Freedland, Matthew Rettig, William J Aronson, Beatrice S Knudsen, Michael S Lewis, Isla P Garraway
BACKGROUND: Benign human prostate tubule-initiating cells (TIC) and aggressive prostate cancer display common traits, including tolerance of low androgen levels, resistance to apoptosis, and microenvironment interactions that drive epithelial budding and outgrowth. TIC can be distinguished from epithelial and stromal cells that comprise prostate tissue via cell sorting based upon Epcam, CD44, and CD49f antigenic profiles. Fetal prostate epithelial cells (FC) possess a similar antigenic profile to adult TIC and are capable of inducing tubule formation...
2016: PloS One
https://www.readbyqxmd.com/read/27667675/comparative-analysis-of-three-histologic-grading-methods-for-squamous-cell-carcinoma-of-the-lip
#17
Luciana Strieder, Cláudia Malheiros Coutinho-Camillo, Victor Costa, Danyel Elias da Cruz Perez, Luiz Paulo Kowalski, Estela Kaminagakura
OBJECTIVES: The aim of this study was to evaluate three histologic grading methods for squamous cell carcinoma (SCC) of the lip, the conventional 3-grade model proposed by the World Health Organization (WHO), tumor budding and depth of invasion (BD) model, and histologic risk assessment (HRA) model, and to correlate them with prognosis. MATERIALS AND METHODS: Fifty-three patients with lip SCC were evaluated. RESULTS: The mean age was 65 years, 69...
September 26, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27634644/proposal-of-a-dukes-mac-like-staging-system-for-gastric-cancer
#18
Simona Gurzu, Haruhiko Sugimura, Janina Orlowska, Janos Szederjesi, Zoltan Szentirmay, Tivadar Bara, Tivadar Bara, Ananmaria Fetyko, Ioan Jung
The aim of this study was to present an epidemiological update regarding the classical prognostic parameters of gastric cancer (GC) in 3 countries from Eastern Europe and to suggest a modification of the pTNM staging system. In 333 consecutive cases which were diagnosed between 2003 and 2012 in 3 departments of pathology from Romania, Hungary, and Poland, the following parameters were analyzed: age and gender of patients, tumor localization, macroscopic and microscopic aspects including the degree of discohesivity, depth of tumor infiltration, and pTNM stage...
September 15, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27622654/a-novel-high-throughput-3d-screening-system-for-emt-inhibitors-a-pilot-screening-discovered-the-emt-inhibitory-activity-of-cdk2-inhibitor-su9516
#19
Kazuya Arai, Takanori Eguchi, M Mamunur Rahman, Ruriko Sakamoto, Norio Masuda, Tetsuya Nakatsura, Stuart K Calderwood, Ken-Ichi Kozaki, Manabu Itoh
Epithelial-mesenchymal transition (EMT) is a crucial pathological event in cancer, particularly in tumor cell budding and metastasis. Therefore, control of EMT can represent a novel therapeutic strategy in cancer. Here, we introduce an innovative three-dimensional (3D) high-throughput screening (HTS) system that leads to an identification of EMT inhibitors. For the establishment of the novel 3D-HTS system, we chose NanoCulture Plates (NCP) that provided a gel-free micro-patterned scaffold for cells and were independent of other spheroid formation systems using soft-agar...
2016: PloS One
https://www.readbyqxmd.com/read/27613105/differences-in-the-rate-of-in-situ-mammary-gland-development-and-other-developmental-endpoints-in-three-strains-of-female-rat-commonly-used-in-mammary-carcinogenesis-studies-implications-for-timing-of-carcinogen-exposure
#20
Jason P Stanko, Grace E Kissling, Vesna A Chappell, Suzanne E Fenton
The potential of chemicals to alter susceptibility to mammary tumor formation is often assessed using a carcinogen-induced study design in various rat strains. The rate of mammary gland (MG) development must be considered so that the timing of carcinogen administration is impactful. In this study, in situ MG development was assessed in females of the Harlan Sprague-Dawley (Hsd:SD), Charles River Sprague-Dawley (Crl:SD), and Charles River Long-Evans (Crl:LE) rat strains at postnatal days 25, 33, and 45. Development was evaluated by physical assessment of growth parameters, developmental scoring, and quantitative morphometric analysis...
October 2016: Toxicologic Pathology
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