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canine parvovirus

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https://www.readbyqxmd.com/read/28414634/detection-of-the-canine-parvovirus-2c-subtype-in-australian-dogs
#1
Lucy Woolford, Paul Crocker, Hannah Bobrowski, Trevor Baker, Farhid Hemmatzadeh
Canine parvovirus (CPV-2) is an important cause of hemorrhagic enteritis in dogs. In Australia the disease has been associated with CPV-2a and CPV-2b variants. A third more recently emerged variant overseas, CPV-2c, has not been detected in surveys of the Australian dog population. In this study, we report three cases of canine parvoviral enteritis associated with CPV-2c infection; case 1 occurred in an 8-week-old puppy that died following acute hemorrhagic enteritis. Cases 2 and 3 were an 11-month-old female entire Saint Bernard and a 9-month-old male entire Siberian husky, respectively, both which had completed vaccination schedules and presented with vomiting or mild diarrhea only...
April 17, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28410597/the-role-of-nuclear-localization-signal-in-parvovirus-life-cycle
#2
REVIEW
Peng Liu, Shun Chen, Mingshu Wang, Anchun Cheng
Parvoviruses are small, non-enveloped viruses with an approximately 5.0 kb, single-stranded DNA genome. Usually, the parvovirus capsid gene contains one or more nuclear localization signals (NLSs), which are required for guiding the virus particle into the nucleus through the nuclear pore. However, several classical NLSs (cNLSs) and non-classical NLSs (ncNLSs) have been identified in non-structural genes, and the ncNLSs can also target non-structural proteins into the nucleus. In this review, we have summarized recent research findings on parvovirus NLSs...
April 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28399176/pathological-findings-in-the-red-fox-vulpes-vulpes-stone-marten-martes-foina-and-raccoon-dog-nyctereutes-procyonoides-with-special-emphasis-on-infectious-and-zoonotic-agents-in-northern-germany
#3
Charlotte Lempp, Nicole Jungwirth, Miguel L Grilo, Anja Reckendorf, Arlena Ulrich, Abbo van Neer, Rogier Bodewes, Vanessa M Pfankuche, Christian Bauer, Albert D M E Osterhaus, Wolfgang Baumgärtner, Ursula Siebert
Anthropogenic landscape changes contributed to the reduction of availability of habitats to wild animals. Hence, the presence of wild terrestrial carnivores in urban and peri-urban sites has increased considerably over the years implying an increased risk of interspecies spillover of infectious diseases and the transmission of zoonoses. The present study provides a detailed characterisation of the health status of the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides) in their natural rural and peri-urban habitats in Schleswig-Holstein, Germany between November 2013 and January 2016 with focus on zoonoses and infectious diseases that are potentially threatening to other wildlife or domestic animal species...
2017: PloS One
https://www.readbyqxmd.com/read/28369886/efficacy-of-feline-anti-parvovirus-antibodies-in-the-treatment-of-canine-parvovirus-infection
#4
M Gerlach, A L Proksch, S Unterer, S Speck, U Truyen, K Hartmann
OBJECTIVE: This prospective, randomised, placebo-controlled, double-blinded study aimed to evaluate efficacy of commercially available feline anti-parvovirus antibodies in dogs with canine parvovirus infection. METHODS: First, cross-protection of feline panleukopenia virus antibodies against canine parvovirus was evaluated in vitro. In the subsequent prospective clinical trial, 31 dogs with clinical signs of canine parvovirus infection and a positive faecal canine parvovirus polymerase chain reaction were randomly assigned to a group receiving feline panleukopenia virus antibodies (n=15) or placebo (n=16)...
March 31, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28362831/the-genetic-evolution-of-canine-parvovirus-a-new-perspective
#5
Pei Zhou, Weijie Zeng, Xin Zhang, Shoujun Li
To trace the evolution process of CPV-2, all of the VP2 gene sequences of CPV-2 and FPV (from 1978 to 2015) from GenBank were analyzed in this study. Then, several new ideas regarding CPV-2 evolution were presented. First, the VP2 amino acid 555 and 375 positions of CPV-2 were first ruled out as a universal mutation site in CPV-2a and amino acid 101 position of FPV feature I or T instead of only I in existing rule. Second, the recently confusing nomenclature of CPV-2 variants was substituted with a optional nomenclature that would serve future CPV-2 research...
2017: PloS One
https://www.readbyqxmd.com/read/28356522/the-minute-virus-of-canines-mvc-np1-protein-governs-the-expression-of-a-subset-of-essential-ns-proteins-via-its-role-in-rna-processing
#6
Olufemi O Fasina, Stephanie Stupps, Wanda Figueroa-Cuilan, David J Pintel
Parvoviruses use a variety of means to control the expression of their compact genomes. The Bocaparvovirus Minute Virus of Canines (MVC) encodes a small, genus-specific protein, NP1, which governs access to the viral capsid gene via its role in alternative polyadenylation and alternative splicing of the single MVC pre-mRNA. In addition to NP1, MVC encodes five additional non-structural proteins (NS) that share an initiation codon at the left end of the genome and which are individually encoded by alternative multiply-spliced mRNAs...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28349355/polymerase-spiral-reaction-psr-a-novel-visual-isothermal-amplification-method-for-detection-of-canine-parvovirus-2-genomic-dna
#7
Vikas Gupta, Soumendu Chakravarti, Vishal Chander, Saurabh Majumder, Shabir Ahmad Bhat, Vivek Kumar Gupta, Sukdeb Nandi
Canine parvovirus-2 (CPV-2), which is ubiquitously distributed worldwide, causes severe and often fatal gastroenteritis in dogs. Accurate, differential and rapid diagnosis of canine parvoviral enteritis remains a challenge for clinicians. A recently developed isothermal amplification technique, polymerase spiral reaction (PSR), was optimized for the first time for a viral pathogen with reference recombinant plasmid standards from different CPV-2 antigenic variants (CPV-2, CPV-2a, CPV-2b and CPV-2c) and subsequently validated using clinical samples...
March 27, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28284623/prevalence-and-molecular-epidemiology-of-canine-parvovirus-2-in-diarrheic-dogs-in-colombia-south-america-a-possible-new-cpv-2a-is-emerging
#8
Yeison Duque-García, Manuela Echeverri-Zuluaga, Juanita Trejos-Suarez, Julian Ruiz-Saenz
Since its identification in 1978, Canine parvovirus type 2 (CPV-2) has been considered a pathogen of great importance in the canine population because it causes severe enteritis with high mortality rates in pups. CPV-2 is a virus belonging to the family Parvoviridae. Currently, there are three described antigenic variants (CPV-2a, CPV-2b, and CPV-2c). CPV-2c is an emerging virus that is seen as a global health hazard. The objective of this work was to confirm the presence of CPV-2 in dogs with acute gastroenteritis compatible with parvovirus and to molecularly characterize the antigenic variants circulating in two regions of Colombia...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28283075/canine-parvovirus-post-vaccination-shedding-interference-with-diagnostic-assays-and-correlation-with-host-immune-status
#9
EDITORIAL
Nicola Decaro, Canio Buonavoglia
No abstract text is available yet for this article.
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28254505/mt-pcr-panel-detection-of-canine-parvovirus-cpv-2-vaccine-and-wild-type-cpv-2-can-be-difficult-to-differentiate-in-canine-diagnostic-fecal-samples
#10
Maira N Meggiolaro, Anna Ly, Benjamin Rysnik-Steck, Carolina Silva, Joshua Zhang, Damien P Higgins, Gary Muscatello, Jacqueline M Norris, Mark Krockenberger, Jan Šlapeta
Canine parvovirus (CPV-2) remains an important cause of devastating enteritis in young dogs. It can be successfully prevented with live attenuated CPV-2 vaccines when given at the appropriate age and in the absence of maternal antibody interference. Rapid diagnosis of parvoviral enteritis in young dogs is essential to ensuring suitable barrier nursing protocols within veterinary hospitals. The current diagnostic trend is to use multiplexed PCR panels to detect an array of pathogens commonly responsible for diarrhea in dogs...
February 27, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28242782/role-of-canine-circovirus-in-dogs-with-acute-haemorrhagic-diarrhoea
#11
A Anderson, K Hartmann, C M Leutenegger, A L Proksch, R S Mueller, S Unterer
Canine circovirus (CanineCV) has been detected in some dogs with severe haemorrhagic diarrhoea, but its pathogenic role is unclear. This study evaluated a suspected association between the presence of CanineCV and acute haemorrhagic diarrhoea syndrome (AHDS) in dogs. The prevalence of CanineCV in dogs with AHDS was compared with that in healthy dogs and those infected with canine parvovirus (CPV). Additionally, time to recovery and mortality rate were compared between CanineCV-positive and CanineCV-negative dogs...
February 27, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28238913/antiviral-activity-of-phosphorylated-radix-cyathulae-officinalis-polysaccharide-against-canine-parvovirus-in-vitro
#12
Haibo Feng, Jing Fan, Shiping Yang, Xuelian Zhao, Xiao Yi
Phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) was prepared according to three-factors, ratio of STMP (%) and STPP (%), reaction time and reaction temperature, and three level L9(3(4)) orthogonal design. The antiviral activity of nine pRCPS (pRCPS1-9) was systematically evaluated by three methods pre-adding mode, mixed mode, and post-adding mode. Cellular activity was tested by the CCK-8 assay. The results showed that the optimal modification conditions were the ratio of STMP (%) and STPP (%) 1:4, reaction time 2h and reaction temperature 65°C...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28237237/expanding-veterinary-biosurveillance-in-washington-dc-the-creation-and-utilization-of-an-electronic-based-online-veterinary-surveillance-system
#13
Andrew Hennenfent, Vito DelVento, John Davies-Cole, Fern Johnson-Clarke
OBJECTIVES: To enhance the early detection of emerging infectious diseases and bioterrorism events using companion animal-based surveillance. METHODS: Washington, DC, small animal veterinary facilities (n=17) were surveyed to determine interest in conducting infectious disease surveillance. Using these results, an electronic-based online reporting system was developed and launched in August 2015 to monitor rates of canine influenza, canine leptospirosis, antibiotic resistant infections, canine parvovirus, and syndromic disease trends...
March 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28192048/a-serosurvey-of-diseases-of-free-ranging-gray-wolves-canis-lupus-in-minnesota
#14
Michelle Carstensen, John H Giudice, Erik C Hildebrand, J P Dubey, John Erb, Dan Stark, John Hart, Shannon Barber-Meyer, L David Mech, Steve K Windels, Andrew J Edwards
We tested serum samples from 387 free-ranging wolves ( Canis lupus ) from 2007 to 2013 for exposure to eight canid pathogens to establish baseline data on disease prevalence and spatial distribution in Minnesota's wolf population. We found high exposure to canine adenoviruses 1 and 2 (88% adults, 45% pups), canine parvovirus (82% adults, 24% pups), and Lyme disease (76% adults, 39% pups). Sixty-six percent of adults and 36% of pups exhibited exposure to the protozoan parasite Neospora caninum . Exposure to arboviruses was confirmed, including West Nile virus (37% adults, 18% pups) and eastern equine encephalitis (3% adults)...
February 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28135131/health-survey-of-free-ranging-raccoons-procyon-lotor-in-central-park-new-york-new-york-usa-implications-for-human-and-domestic-animal-health
#15
Kimberly L Rainwater, Krysten Marchese, Sally Slavinski, Lee A Humberg, Edward J Dubovi, Jodie A Jarvis, Denise McAloose, Paul P Calle
We conducted health assessments on 113 free-ranging raccoons ( Procyon lotor ) in Central Park, New York City, US, in February 2010, September 2010, and November 2011 in conjunction with a trap-vaccinate-release program to control a raccoon rabies epizootic. Five individuals were sampled at two time points for 118 raccoon examinations in total. We tested 13 of 13 and 8 of 13 euthanized raccoons for rabies and canine distemper virus (CDV), respectively, by antigen testing on brain tissue; all were negative for both viruses...
April 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28125171/prevalence-of-increased-canine-pancreas-specific-lipase-concentrations-in-young-dogs-with-parvovirus-enteritis
#16
Irida V Kalli, Katerina K Adamama-Moraitou, Michael N Patsika, Dimitra Pardali, Jörg M Steiner, Jan S Suchodolski, George Menexes, Georgia D Brellou, Timoleon S Rallis
BACKGROUND: Pancreatic abnormalities during canine parvovirus (CPV) enteritis have not been studied prospectively. OBJECTIVES: The objective of this study was to evaluate the diagnostic significance of canine serum pancreas-specific lipase (Spec cPL) concentration in dogs with CPV enteritis for the presence of acute pancreatitis (AP). Puppies with naturally occurring CPV enteritis were recruited and prospectively allocated into 2 groups according to normal or increased serum Spec cPL concentration...
January 26, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28124140/molecular-characterization-of-canine-parvovirus-in-vientiane-laos
#17
Soulasack Vannamahaxay, Souliya Vongkhamchanh, Montira Intanon, Sahatchai Tangtrongsup, Saruda Tiwananthagorn, Kidsadagon Pringproa, Phongsakorn Chuammitri
The global emergence of canine parvovirus type 2c (CPV-2c) has been well documented. In the present study, 139 rectal swab samples collected from diarrheic dogs living in Vientiane, Laos, in 2016 were tested for the presence of the canine parvovirus (CPV) VP2 gene by PCR. The results showed that 82.73% (115/139) of dogs were CPV positive by PCR. The partial VP2 gene was sequenced in 94 of the positive samples; 91 samples belonged to CPV-2c (426Glu) subtype, while 3 samples belonged to the CPV-2a (426Asn) subtype...
January 25, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28109291/systemic-nocardiosis-in-a-dog-caused-by-nocardia-cyriacigeorgica
#18
Yesari Eroksuz, Nafia Canan Gursoy, Tolga Karapinar, Burak Karabulut, Canan Akdeniz Incili, Zeynep Yerlikaya, Zulal Asci Toraman, Mehmet Ozkan Timurkan, Hatice Eroksuz
BACKGROUND: Systemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs. CASE PRESENTATION: Light and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes...
January 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28093104/faecal-shedding-of-canine-parvovirus-after-modified-live-vaccination-in-healthy-adult-dogs
#19
M Freisl, S Speck, U Truyen, S Reese, A-L Proksch, K Hartmann
Since little is known about the persistence and faecal shedding of canine parvovirus (CPV) in dogs after modified-live vaccination, diagnostic tests for CPV can be difficult to interpret in the post-vaccination period. The primary aim of this study was to determine the incidence, duration and extent of CPV vaccine virus shedding in adult dogs and to investigate related factors, including the presence of protective antibodies, increase in anti-CPV antibody titres and development of any gastrointestinal side-effects...
January 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28040513/novel-chimeric-virus-like-particles-vaccine-displaying-mers-cov-receptor-binding-domain-induce-specific-humoral-and-cellular-immune-response-in-mice
#20
Chong Wang, Xuexing Zheng, Weiwei Gai, Gary Wong, Hualei Wang, Hongli Jin, Na Feng, Yongkun Zhao, Weijiao Zhang, Nan Li, Guoxing Zhao, Junfu Li, Jinghua Yan, Yuwei Gao, Guixue Hu, Songtao Yang, Xianzhu Xia
Middle East respiratory syndrome coronavirus (MERS-CoV) has continued spreading since its emergence in 2012 with a mortality rate of 35.6%, and is a potential pandemic threat. Prophylactics and therapies are urgently needed to address this public health problem. We report here the efficacy of a vaccine consisting of chimeric virus-like particles (VLP) expressing the receptor binding domain (RBD) of MERS-CoV. In this study, a fusion of the canine parvovirus (CPV) VP2 structural protein gene with the RBD of MERS-CoV can self-assemble into chimeric, spherical VLP (sVLP)...
April 2017: Antiviral Research
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