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canine parvovirus

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https://www.readbyqxmd.com/read/29134762/introduction-of-asian-canine-parvovirus-in-europe-through-dog-importation
#1
F Mira, G Purpari, E Lorusso, S Di Bella, F Gucciardi, C Desario, G Macaluso, N Decaro, A Guercio
Canine parvovirus (CPV) is an important infectious agent of domestic and wild carnivores, responsible for severe and often fatal haemorrhagic gastroenteritis and leukopenia. This paper reports the genomic characterization of a CPV strain collected from a dog recently imported to Italy from Thailand. The virus was detected in all tissue samples collected. The whole genome encompassing the two open reading frames encoding for non-structural (NS1/NS2) and structural (VP1/VP2) proteins was amplified and sequenced...
November 13, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29133942/canine-parvovirus-ns1-gene-and-chicken-anemia-vp3-gene-induce-partial-oncolysis-of-canine-transmissible-venereal-tumor
#2
Aubid Hussain Bhat, Bhaskar Ganguly, Ashok Kumar Tiwari, Arup Kumar Das
The oncolytic effect of Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene in naturally occurring cases of Canine Transmissible Venereal Tumor (CTVT) is being reported. Dogs suffering from CTVT (N = 18) were systematically randomized into three groups viz. A, B, and C (n = 6). Animals of the groups A, B, and C received 100 µg of the ns1 gene, vp3 gene, and ns1  +  vp3 gene combination, respectively, for three weeks intratumorally at weekly intervals; results were normalized against base values before commencement of therapy and after complete remission that were taken as negative and positive controls, respectively...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127489/genetic-characterization-of-the-complete-genome-of-a-mutant-canine-parvovirus-isolated-in-china
#3
Chuanfeng Li, Jingyu Tang, Zongyan Chen, Qi Li, Zhenhua Huang, Quan Wang, Chunchun Meng, Yong Wang, Guangqing Liu
A field canine parvovirus (CPV) strain, CPV-SH14, was previously isolated from an outbreak of severe gastroenteritis in Shanghai in 2014. The complete genome of CPV-SH14 was determined by using PCR with modified primers. When compared to other CPV-2 strains, several insertions, deletions, and point mutations were identified in the 5' and 3' UTR, with key amino acid (aa) mutations (K19R, E572K in NS1 and F267Y, Y324I and T440A in VP2) also being observed in the coding regions of CPV-SH14. These results indicated that significant and unique genetic variations have occurred at key sites or residues in the genome of CPV-SH14, suggesting the presence of a novel genetic variant of new CPV-2a...
November 10, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29110666/development-of-real-time-recombinase-polymerase-amplification-assay-for-rapid-and-sensitive-detection-of-canine-parvovirus-2
#4
Yunyun Geng, Jianchang Wang, Libing Liu, Yan Lu, Ke Tan, Yan-Zhong Chang
BACKGROUND: Canine parvovirus 2, a linear single-stranded DNA virus belonging to the genus Parvovirus within the family Parvoviridae, is a highly contagious pathogen of domestic dogs and several wild canidae species. Early detection of canine parvovirus (CPV-2) is crucial to initiating appropriate outbreak control strategies. Recombinase polymerase amplification (RPA), a novel isothermal gene amplification technique, has been developed for the molecular detection of diverse pathogens...
November 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29103701/are-vaccine-strain-type-or-administration-protocol-risk-factors-for-canine-parvovirus-vaccine-failure
#5
K D Altman, M Kelman, M P Ward
Canine parvovirus (CPV) is a highly contagious and worldwide cause of serious and often fatal disease in dogs, despite the widespread availability of vaccines. Which vaccine-related factors are associated with vaccination failure is largely unknown, and there are no reports from Australia. In this study - the first national population-level CPV study of its kind ever conducted - we analysed data on 594 cases of apparent CPV vaccination failure reported from an Australian national surveillance system to determine whether vaccine strain, type or administration protocol are risk factors for vaccination failures...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29049413/microrna-expression-analysis-of-feline-and-canine-parvovirus-infection-in-vivo-felis
#6
Pei Zhou, Xin Zhang, Weijie Zeng, Qingxu Zheng, Xiangqi Hao, Xi Lin, Yun Zheng, Lifang Wang, Guihong Zhang, Shoujun Li
Feline panleukopenia is a common contagious disease with high morbidity and mortality. At present, feline parvovirus (FPV) and canine parvovirus (CPV) variants are the pathogens of feline panleukopenia. Many studies have shown that miRNAs are involved in virus-host interactions. Nevertheless, miRNA expression profiling of FPV (original virus) or CPV-2b (new virus) in cats has not been reported. To investigate these profiles, three 10-week-old cats were orally inoculated with 106 TCID50 of the viruses (FPV and CPV-2b), and the jejunums of one cat in each group were sectioned for miRNA sequencing at 5 days post-inoculation (dpi)...
2017: PloS One
https://www.readbyqxmd.com/read/28984228/substitutions-at-residues-300-and-389-of-the-vp2-capsid-protein-serve-as-the-minimal-determinant-of-attenuation-for-canine-parvovirus-vaccine-strain-9985-46
#7
Go Sehata, Hiroaki Sato, Morimasa Yamanaka, Takuo Takahashi, Risa Kainuma, Tatsuhiko Igarashi, Sho Oshima, Taichi Noro, Eiji Oishi
Identifying molecular determinants of virulence attenuation in live attenuated canine parvovirus (CPV) vaccines is important for assuring their safety. To this end, we identified mutations in the attenuated CPV 9985-46 vaccine strain that arose during serial passage in Crandell-Rees feline kidney cells by comparison with the wild-type counterpart, as well as minimal determinants of the loss of virulence. Four amino acid substitutions (N93K, G300V, T389N and V562L) in VP2 of strain 9985-46 significantly restricted infection in canine A72 cells...
November 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28973725/full-length-genomic-and-molecular-characterization-of-canine-parvovirus-in-dogs-from-north-of-brazil
#8
S P Silva, L N P P Silva, E D L Rodrigues, J F Cardoso, F N Tavares, W M Souza, C M P Santos, F M S Martins, I S Jesus, T C Brito, T P C Moura, M R T Nunes, L M N Casseb, E Silva Filho, A R Casseb
With the objective of characterizing Canine parvovirus (CPV) from some suspected fecal samples of dogs collected from the Veterinarian Hospital in Belém city, five positive samples were found by PCR assay and an update molecular characterization was provided of the CPV-2 circulation in Belém. Through sequencing of the complete DNA sequences (NS1, NS2, VP1, and VP2 genes), the CPV-2 strain was identified as CPV-2b (Asn426Asp) circulating in Belém. The CPV-2b strain with a different change at the position Tyr324Leu was detected in all samples assessed and thus reported for the first time for the scientific community...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28957693/interferon-omega-current-status-in-clinical-applications
#9
REVIEW
Shi-Fang Li, Fu-Rong Zhao, Jun-Jun Shao, Yin-Li Xie, Hui-Yun Chang, Yong-Guang Zhang
Since 1985, interferon (IFN)-ω, a type I IFN, has been identified in many animals, but not canines and mice. It has been demonstrated to have antiviral, anti-proliferation, and antitumor activities that are similar to those of IFN-α. To date, IFN-ω has been explored as a treatment option for some diseases or viral infections in humans and other animals. Studies have revealed that human IFN-ω displays antitumor activities in some models of human cancer cells and that it can be used to diagnose some diseases...
September 25, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28947335/epidemiology-and-molecular-characterization-of-protoparvoviruses-infecting-wild-raccoons-procyon-lotor-in-british-columbia-canada
#10
Marta Canuti, Ann P Britton, Stephanie M Graham, Andrew S Lang
Feline panleukopenia virus (FPV) and canine parvovirus 2 (CPV-2) belong to the species Carnivore protoparvovirus 1. While FPV has been endemic in cats for many years, CPV-2 emerged at the end of the 1970s and 3 antigenic variants (CPV-2a, b and c) are currently circulating in domestic and wild animals. Although raccoons played a fundamental role in the emergence of CPV-2a in dogs, knowledge about protoparvoviruses in these animals is still limited. We investigated 72 raccoons found dead or injured in southern British Columbia (BC), Canada, between 2009 and 2017...
September 22, 2017: Virus Research
https://www.readbyqxmd.com/read/28935611/introduction-of-canine-parvovirus-2-into-wildlife-on-the-island-of-newfoundland-canada
#11
Marta Canuti, Bruce Rodrigues, Hugh G Whitney, Andrew S Lang
Canine parvovirus-2 (CPV-2) and feline panleukopenia virus (FPV) (species Carnivore protoparvovirus 1, family Parvoviridae) cause a severe gastrointestinal disease associated with immune depression in a broad range of terrestrial carnivores. We report here the first molecular epidemiological investigation of protoparvoviruses on the Island of Newfoundland, Canada. In particular, we investigated red foxes (Vulpes vulpes deletrix) and lynx (Lynx canadensis subsolanus), two autochthonous species, and coyotes (Canis latrans), which immigrated onto the island during the 1980s...
September 18, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28919674/prevalence-of-enteropathogens-and-their-antibiotic-sensitivity-pattern-in-puppies-with-hemorrhagic-gastroenteritis
#12
A Kokila Priya, M Balagangatharathilagar, D Chandrasekaran, M Parthiban, S Prathaban
AIM: Hemorrhagic gastroenteritis (HGE) ranging from mild to severe forms is commonly encountered in puppies. The aim of the study was to identify the prevalence of common enteropathogens and the antibiotic sensitivity pattern in puppies reported with HGE. MATERIALS AND METHODS: The canine HGE activity index, with little modification, was adopted to identify Grade III/severely affected puppies below 6 months of age. Fecal polymerase chain reaction (PCR) assay was employed to screen and compare the enteropathogens in puppies with hemorrhagic diarrhea and healthy control...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28895871/type-i-interferons-in-the-pathogenesis-and-treatment-of-canine-diseases
#13
REVIEW
Daniela Klotz, Wolfgang Baumgärtner, Ingo Gerhauser
Type I interferons (IFNs) such as IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω represent cytokines, which are deeply involved in the regulation and activation of innate and adaptive immune responses. They possess strong antiviral, antiproliferative, and immunomodulatory activities allowing their use in the therapy of different viral diseases, neoplasms, and immune-mediated disorders, respectively. Initially, treatment strategies were based on nonspecific inducers of type I IFNs, which were soon replaced by different recombinant proteins...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28852158/investigation-of-a-canine-parvovirus-outbreak-using-next-generation-sequencing
#14
Jayme Parker, Molly Murphy, Karsten Hueffer, Jack Chen
Canine parvovirus (CPV) outbreaks can have a devastating effect in communities with dense dog populations. The interior region of Alaska experienced a CPV outbreak in the winter of 2016 leading to the further investigation of the virus due to reports of increased morbidity and mortality occurring at dog mushing kennels in the area. Twelve rectal-swab specimens from dogs displaying clinical signs consistent with parvoviral-associated disease were processed using next-generation sequencing (NGS) methodologies by targeting RNA transcripts, and therefore detecting only replicating virus...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28834737/immunocapture-loop-mediated-isothermal-amplification-assays-for-the-detection-of-canine-parvovirus
#15
Yu-Ling Sun, Chon-Ho Yen, Ching-Fu Tu
A loop-mediated isothermal amplification (LAMP) assay was used for rapid canine parvovirus (CPV) diagnosis. To reduce the time required and increase the sensitivity of the assay, an immunocapture (IC) technique was developed in this study to exclude the DNA extraction step in molecular diagnostic procedures for CPV. A polyclonal rabbit anti-CPV serum was produced against VP2-EpC that was cloned via DNA recombination. The polyclonal anti-VP2-EpC serum was used for virus capture to prepare microtubes. IC-LAMP was performed to amplify a specific CPV target gene sequence from the CPV viral particles that were captured on the microtubes, and the amplicons were analyzed using agarose electrophoresis or enzyme-linked immunosorbent assay (IC-LAMP-ELISA) and lateral-flow dipstick (IC-LAMP-LFD)...
August 20, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28812526/parvovirus-infection-is-associated-with-myocarditis-and-myocardial-fibrosis-in-young-dogs
#16
Jordan Ford, Laura McEndaffer, Randall Renshaw, Alex Molesan, Kathleen Kelly
Perinatal parvoviral infection causes necrotizing myocarditis in puppies, which results in acute high mortality or progressive cardiac injury. While widespread vaccination has dramatically curtailed the epidemic of canine parvoviral myocarditis, we hypothesized that canine parvovirus 2 (CPV-2) myocardial infection is an underrecognized cause of myocarditis, cardiac damage, and/or repair by fibrosis in young dogs. In this retrospective study, DNA was extracted from formalin-fixed, paraffin-embedded tissues from 40 cases and 41 control dogs under 2 years of age from 2007 to 2015...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28810858/rapid-and-sensitive-detection-of-canine-distemper-virus-by-real-time-reverse-transcription-recombinase-polymerase-amplification
#17
Jianchang Wang, Jinfeng Wang, Ruiwen Li, Libing Liu, Wanzhe Yuan
BACKGROUND: Canine distemper, caused by Canine distemper virus (CDV), is a highly contagious and fatal systemic disease in free-living and captive carnivores worldwide. Recombinase polymerase amplification (RPA), as an isothermal gene amplification technique, has been explored for the molecular detection of diverse pathogens. METHODS: A real-time reverse transcription RPA (RT-RPA) assay for the detection of canine distemper virus (CDV) using primers and exo probe targeting the CDV nucleocapsid protein gene was developed...
August 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28808849/a-rapid-method-for-establishment-of-a-reverse-genetics-system-for-canine-parvovirus
#18
Yongle Yu, Jun Su, Jigui Wang, Ji Xi, Yaping Mao, Qiang Hou, Xiaomei Zhang, Weiquan Liu
Canine parvovirus (CPV) is an important and highly prevalent pathogen of dogs that causes acute hemorrhagic enteritis disease. Here, we describe a rapid method for the construction and characterization of a full-length infectious clone (rCPV) of CPV. Feline kidney (F81) cells were transfected with rCPV incorporating an engineered EcoR I site that served as a genetic marker. The rescued virus was indistinguishable from that of wild-type virus in its biological properties.
August 14, 2017: Virus Genes
https://www.readbyqxmd.com/read/28733230/clostridium-perfringens-and-c-%C3%A2-difficile-in-parvovirus-positive-dogs
#19
Rodrigo Otávio Silveira Silva, Fernanda Alves Dorella, Henrique Cesar Pereira Figueiredo, Érica Azevedo Costa, Vanessa Pelicia, Bruna Letícia Devidé Ribeiro, Marcio Garcia Ribeiro, Antonio Carlos Paes, Jane Megid, Francisco Carlos Faria Lobato
The aim of this study was to investigate Clostridium difficile and Clostridium perfringens in 82 diarrheic dogs positive for canine parvovirus type 2 (CPV). Enterotoxigenic C. perfringens type A was isolated from three (3.6%) dogs. One (1.2%) strain was also positive for NetE- and NetF-encoding genes, which are commonly associated with diarrhea in dogs. Toxigenic C. difficile was isolated from one animal (1.2%), which was also positive for A/B toxins. The present study identified C. difficile and C. perfringens infection in CPV-positive dogs...
July 19, 2017: Anaerobe
https://www.readbyqxmd.com/read/28716388/identification-of-co-infection-by-rotavirus-and-parvovirus-in-dogs-with-gastroenteritis-in-mexico
#20
Ariadna Flores Ortega, José Simón Martínez-Castañeda, Linda G Bautista-Gómez, Raúl Fajardo Muñoz, Israel Quijano Hernández
This is the first report on circulating canine rotavirus in Mexico. Fifty samples from dogs with gastroenteritis were analyzed used polymerase chain reaction and reverse transcription polymerase chain reaction in order to identify parvovirus and rotavirus, respectively; 7% of dogs were infected with rotavirus exclusively, while 14% were co-infected with both rotavirus and parvovirus; clinical signs in co-infected dogs were more severe.
October 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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