Philip D Tatman, David P Kao, Kathryn C Chatfield, Ian A Carroll, Jessica A Wagner, Eric R Jonas, Carmen C Sucharov, J David Port, Brian D Lowes, Wayne A Minobe, Sophia P Huebler, Anis Karimpour-Fard, Erin M Rodriguez, Stephen B Liggett, Michael R Bristow
We investigated the extent, biologic characterization, phenotypic specificity, and possible regulation of a β1-adrenergic receptor-linked (β1-AR-linked) gene signaling network (β1-GSN) involved in left ventricular (LV) eccentric pathologic remodeling. A 430-member β1-GSN was identified by mRNA expression in transgenic mice overexpressing human β1-ARs or from literature curation, which exhibited opposite directional behavior in interventricular septum endomyocardial biopsies taken from patients with beta-blocker-treated, reverse remodeled dilated cardiomyopathies...
August 22, 2023: JCI Insight