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endomyocardial fibrosis

Suneesh Kalliath, Rajesh Gopalan Nair, Haridasan Vellani
A 48-year-old man presented with chronic right sided heart failure. 2D echocardiography revealed the classical features of left ventricular endomyocardial fibrosis with a prominent right ventricular apical aneurysm. Right ventriculography further defined the aneurysm. Cardiac magnetic resonance images revealed a thin-walled, apical aneurysm of right ventricle with multiple septations and marked obliteration of left ventricular apex. A delayed-enhancement sequence after the infusion of contrast, demonstrated a hypersignal in the subendocardium, consistent with the right ventricular involvement of endomyocardial fibrosis...
September 2016: Indian Heart Journal
Mukund A Prabhu, B V Srinivas Prasad, Anees Thajudeen, Narayanan Namboodiri
INTRODUCTION: Bundle branch reentry as a mechanism of ventricular tachycardia (VT) in endomyocardial fibrosis (EMF) is not described. CASE REPORT: A 52-year-old woman with left ventricular (LV) EMF had VT needing cardioversion. She had mitral regurgitation and left bundle branch block, but no LV dilation or heart failure. During electrophysiological study, clinical VT could be easily induced, and it was confirmed to be bundle branch reentrant VT (BBRVT). She was treated with ablation of the right bundle branch...
September 2016: Indian Heart Journal
Rajiv Ananthakrishna, Nagaraja Moorthy
Myocardial calcification is rare and occurs in previous myocardial infarction, endomyocardial fibrosis, and infections such as tuberculosis, chronic renal failure, or hyperparathyroidism. We present an interesting case of massive myocardial calcification of the left ventricle following prior extensive myocardial infarction, presenting as progressive heart failure.
September 2016: Indian Heart Journal
Mahim Saran, Sivasankaran Sivasubramonian
A 55-year-old female presented with worsening dyspnea secondary to left ventricular endomyocardial fibrosis (EMF). Obliteration of left ventricular apex and hypertrophied papillary muscle gave the classical appearance of a "doughnut" on left ventricular angiography. We present here a novel doughnut appearance of left ventricle on angiogram.
September 2016: Indian Heart Journal
Saumya Tiwari, Jai Raman, Vijaya Reddy, Andrew Ghetler, Richard P Tella, Yang Han, Christopher R Moon, Charles D Hoke, Rohit Bhargava
Fourier transform infrared (FT-IR) spectroscopic imaging has been widely tested as a tool for stainless digital histology of biomedical specimens, including for the identification of infiltration and fibrosis in endomyocardial biopsy samples to assess transplant rejection. A major barrier in clinical translation has been the slow speed of imaging. To address this need, we tested and report here the viability of using high speed discrete frequency infrared (DFIR) imaging to obtain stain-free biochemical imaging in cardiovascular samples collected from patients...
October 18, 2016: Analytical Chemistry
Y-Q He, J-M Zhu, Y-N Zhao, L Liu, H Zeng, P Yang
Idiopathic hypereosinophilic syndrome (IHES) is a rare disease involving multiple vital organ systems. Here we present the case of a 42-year-old man who had IHES associated with simultaneously occurring endomyocardial fibrosis, thrombi, and pulmonary and skin infiltration. The patient was referred to our hospital with electrocardiographic and biochemical cardiac marker abnormalities suggesting acute coronary syndrome. The patient's condition aggravated within one month, but was greatly improved with the combination therapy of glucocorticoids, hydroxyurea, warfarin and standard treatment for heart failure...
March 10, 2016: West Indian Medical Journal
Avishay Grupper, Jose Nativi-Nicolau, Joseph J Maleszewski, Jennifer R Geske, Walter K Kremers, Brooks S Edwards, Sudhir S Kushwaha, Naveen L Pereira
OBJECTIVES: This study evaluated changes in serum levels of galectin-3 (Gal-3) before and after heart transplantation (HTx) and assessed the role of pre-HTx Gal-3 as a biomarker for post-HTx outcomes. BACKGROUND: Gal-3 is a novel biomarker that reflects cardiac remodeling and fibrosis. Elevated serum Gal-3 levels are associated with poor prognosis in heart failure patients. Whether Gal-3 levels change following HTx and the significance of post-HTx outcomes are unknown...
August 27, 2016: JACC. Heart Failure
Agnieszka Madej-Pilarczyk, Adam Niezgoda, Magdalena Janus, Romuald Wojnicz, Michał Marchel, Anna Fidziańska, Stefan Grajek, Irena Hausmanowa-Petrusewicz
Laminopathies, a group of heterogeneous disorders associated with lamin A/C gene (LMNA) mutations, encompass a wide spectrum of clinical phenotypes, which may present as separate disease or as overlapping syndromes. We describe a 35-year-old female in whom a novel sporadic heterozygous mutation c.1001_1003delGCC (p.Ser334del) of the LMNA gene was found. The patient presented with overlapping syndrome of heart failure secondary to dilated cardiomyopathy, limb-girdle dystrophy and partial lipodystrophy. Endomyocardial biopsy revealed strong up-regulation of HLA classes I and II antigens on microvessels and induction of the class I antigens on cardiomyocytes...
September 1, 2016: Journal of Applied Genetics
Svetlana I Sazonova, Julia N Ilyushenkova, Yuri B Lishmanov, Roman E Batalov, Alexey E Sazonov, Ludmila A Larionova, Evgeniy A Nesterov, Natalia V Varlamova, Julia V Rogovskaya, Tatyana A Shelkovnikova, Sergey V Popov
OBJECTIVE: Aim was to study the performance of single-photon emission computed tomography (SPECT) with (99m)Tc-pyrophosphate ((99m)Tc-PYP) in diagnostics of chronic latent inflammation in myocardium of patients with atrial fibrillation (AF). METHODS: The research included 70 patients (the average age of 49.3 ± 10.2 years) with persistent form of idiopathic AF. All patients underwent myocardium SPECT with (99m)Tc-PYP and cardiac magnetic resonance imaging (CMR) before the ablation...
August 24, 2016: Annals of Nuclear Medicine
Joseph Xavier, Maruti Yamanappa Haranal, Shashidhar Ranga Reddy, Sharadaprasad Suryaprakash
Mitral valve prolapse in endomyocardial fibrosis (EMF) is an unusual entity. Literature search reveals only 1 report of mitral valve prolapse assosiated with EMF. A 32-year-old woman, of African origin, who presented with features of right heart failure, was diagnosed to have mitral valve prolapse of rheumatic origin with severe mitral regurgitation and severe pulmonary hypertension (PAH). Intraoperative findings lead to the diagnosis of EMF. We report this rare case of mitral valve prolapse in EMF, in a geographical area where rheumatic heart disease is endemic, to showcase how a rare manifestation of EMF can be misdiagnosed as that of rheumatic heart disease...
September 2016: Annals of Thoracic Surgery
Paweł Rubiś, Sylwia Wiśniowska-Śmialek, Ewa Wypasek, Barbara Biernacka-Fijalkowska, Lucyna Rudnicka-Sosin, Ewa Dziewiecka, Patrycja Faltyn, Lusine Khachatryan, Aleksandra Karabinowska, Artur Kozanecki, Lidia Tomkiewicz-Pająk, Piotr Podolec
BACKGROUND: Fibrosis of extracellular matrix (ECM) in dilated cardiomyopathy (DCM) corresponds to the myocardial over-production of various types of collagens. However, mechanism of this process is poorly understood. OBJECTIVE: To investigate whether enhanced metabolism of ECM occur in DCM. METHODS: Seventy consecutive DCM patients (pts) (48 ± 12.1 years, EF 24.4 ± 7.4 %) and 20 healthy volunteers were studied. Based on symptoms duration, pts were divided into new-onset (n = 35, 6 months) and chronic DCM (n = 35, >6 months)...
August 11, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Sonoko Maemura, Eisuke Amiya, Hikari Seki, Kazutaka Ueda, Daisuke Nitta, Teruhiko Imamura, Masae Uehara, Takayuki Kawata, Masafumi Watanabe, Masaru Hatano, Koichiro Kinugawa, Issei Komuro
No abstract text is available yet for this article.
August 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Dominik Rath, Madhumita Chatterjee, Angela Bongartz, Karin Müller, Michal Droppa, Fabian Stimpfle, Oliver Borst, Christine Zuern, Sebastian Vogel, Meinrad Gawaz, Tobias Geisler
Platelet surface expression levels of stromal cell derived factor 1 (SDF-1) are elevated in acute coronary syndrome and associated with LVEF% improvement after myocardial infarction (MI). Platelet SDF-1 might facilitate thrombus formation and endomyocardial expression of SDF-1 is enhanced in inflammatory cardiomyopathy and positively correlates with myocardial fibrosis. The influence of platelet SDF-1 on outcome in the patients with symptomatic coronary artery disease (CAD) is to the best of our knowledge unknown...
July 27, 2016: Platelets
Kapka Miteva, Sophie Van Linthout, Kathleen Pappritz, Irene Müller, Frank Spillmann, Marion Haag, Harald Stachelscheid, Jochen Ringe, Michael Sittinger, Carsten Tschöpe
: : Cardiac-derived adherent proliferating cells (CardAPs) are cells derived from human endomyocardial biopsy specimens; they share several properties with mesenchymal stromal cells. The aims of this study were to evaluate whether intramyocardial injection of CardAPs modulates cardiac fibrosis and hypertrophy in a mouse model of angiotensin II (Ang II)-induced systolic heart failure and to analyze underlying mechanisms. Intramyocardial application of 200,000 CardAPs improved left ventricular function...
July 26, 2016: Stem Cells Translational Medicine
Prabhakar Rajiah, Samreen Raza, Sachin S Saboo, Brian Ghoshhajra, Suhny Abbara
Cardiomyopathies refer to a variety of myocardial disorders without underlying coronary artery disease, valvular heart disease, hypertension, or congenital heart disease. Several imaging modalities are available, but cardiac magnetic resonance (CMR) has now established itself as a crucial imaging technique in the evaluation of several cardiomyopathies. It not only provides comprehensive information on structure and function, but also can perform tissue characterization, which helps in establishing the etiology of cardiomyopathy...
November 2016: Journal of Thoracic Imaging
Sabine Ameling, Gourav Bhardwaj, Elke Hammer, Daniel Beug, Leif Steil, Yvonne Reinke, Kerstin Weitmann, Markus Grube, Christiane Trimpert, Karin Klingel, Reinhard Kandolf, Wolfgang Hoffmann, Matthias Nauck, Marcus Dörr, Klaus Empen, Stephan B Felix, Uwe Völker
Immunoadsorption with subsequent immunoglobulin substitution (IA/IgG) represents a therapeutic approach for patients with dilated cardiomyopathy (DCM). Here, we studied which molecular cardiac alterations are initiated after this treatment. Transcription profiling of endomyocardial biopsies with Affymetrix whole genome arrays was performed on 33 paired samples of DCM patients collected before and 6 months after IA/IgG. Therapy-related effects on myocardial protein levels were analysed by label-free proteome profiling for a subset of 23 DCM patients...
September 2016: Basic Research in Cardiology
Martial M Massin, Caroline Jacquemart, Nasroolla Damry
Eosinophilic endomyocarditis is extremely rare in paediatrics. This case report aims to present the sequential changes from thrombotic to fibrotic stages of the cardiac involvement in a child with hypereosinophilic syndrome. Endomyocardial fibrosis progressively aggravated the severity of the mitral regurgitation. Bioprosthetic valve replacement was finally performed without recurrence of cardiac complications despite a late relapse of the underlying disease.
June 22, 2016: Cardiology in the Young
Antonio Grimaldi, Ana Olga Mocumbi, Juergen Freers, Matthias Lachaud, Mariana Mirabel, Beatriz Ferreira, Kumar Narayanan, David S Celermajer, Daniel Sidi, Xavier Jouven, Eloi Marijon
Tropical endomyocardial fibrosis (EMF) is a neglected disease of poverty that afflicts rural populations in tropical low-income countries, with some certain high-prevalence areas. Tropical EMF is characterized by the deposition of fibrous tissue in the endomyocardium, leading to restrictive physiology. Since the first descriptions in Uganda in 1948, high-frequency areas for EMF have included Africa, Asia, and South America. Although there is no clear consensus on a unified hypothesis, it seems likely that dietary, environmental, and infectious factors may combine in a susceptible individual to give rise to an inflammatory process leading to endomyocardial damage and scar formation...
June 14, 2016: Circulation
Christian Besler, Daniel Urban, Stefan Watzka, David Lang, Karl-Philipp Rommel, Reinhard Kandolf, Karin Klingel, Holger Thiele, Axel Linke, Gerhard Schuler, Volker Adams, Philipp Lurz
AIMS: Inflammatory heart disease represents an important cause of chronic dilated cardiomyopathy (DCM). Predicting the clinical course of patients with inflammatory cardiomyopathy (iCMP) is difficult, and the prognostic value of current biological markers remains controversial. We tested whether expression of selected microRNAs in endomyocardial biopsies (EMBs) is related to LV functional recovery and clinical events in iCMP patients. METHODS AND RESULTS: EMBs were obtained from patients with iCMP (n = 76) and non-inflammatory DCM (n = 22)...
June 13, 2016: European Journal of Heart Failure
Giacomo Vandi, Leonardo Calza, Nicolò Girometti, Roberto Manfredi, Giuseppina Musumeci, Isabella Bon, Maria Carla Re
A 30-year-old man was admitted to hospital after complaining of a retrosternal burning pain, radiating to the jugular region, and to both upper limbs. An electrocardiography examination showed a ST segment elevation involving the lower-lateral leads. A trans-thoracic ultrasonography showed findings compatible with an acute myopericarditis. All performed serological testings excluded other recent infections with cardiac tropism. Among screening tests, a peripheral lymphocyte subset analysis was performed and an inversion of the CD4/CD8 ratio was found...
June 6, 2016: International Journal of STD & AIDS
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