keyword
https://read.qxmd.com/read/38531705/review-phenotypic-and-molecular-evidence-of-inter-and-trans-generational-effects-of-heat-stress-in-livestock-mammals-and-humans
#1
REVIEW
J Laporta, H Khatib, M Zachut
Internal and external factors can change an individual's phenotype. A significant external threat to humans and livestock is environmental heat load, a combination of high ambient temperatures and humidity. A heat stress response occurs when an endothermal animal is exposed to a heat load that challenges its' thermoregulation capacity. With the ongoing climate change trends, the incidence of chronically elevated temperatures causing heat stress is expected to rise, posing an even greater risk to the health and survival of all species...
February 29, 2024: Animal
https://read.qxmd.com/read/38521130/melatonin-supplementation-in-obese-mothers-reduces-hypothalamic-inflammation-and-enhances-thermogenesis-in-mice-progeny
#2
JOURNAL ARTICLE
Brenda A Nagagata, Gabrielle Brito, Fernanda Ornellas, Carlos A Mandarim-de-Lacerda, Marcia Barbosa Aguila
Maternal obesity might induce obesity and metabolic alterations in the progeny. The study aimed to determine the effect of supplementing obese mothers with Mel (Mel) on thermogenesis and inflammation. C57BL/6 female mice (mothers) were fed from weaning to 12 weeks control diet (C, 17 % kJ as fat) or a high-fat diet (HF, 49 % kJ as fat) and then matted with male mice fed the control diet. Melatonin (10 mg/kg daily) was supplemented to mothers during gestation and lactation, forming the groups C, CMel, HF, and HFMel (n=10/group)...
March 21, 2024: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/38474810/nutritional-approaches-targeting-gut-microbiota-in-oxidative-stress-associated-metabolic-syndrome-focus-on-early-life-programming
#3
REVIEW
You-Lin Tain, Chien-Ning Hsu
Metabolic syndrome (MetS) denotes a constellation of risk factors associated with the development of cardiovascular disease, with its roots potentially traced back to early life. Given the pivotal role of oxidative stress and dysbiotic gut microbiota in MetS pathogenesis, comprehending their influence on MetS programming is crucial. Targeting these mechanisms during the early stages of life presents a promising avenue for preventing MetS later in life. This article begins by examining detrimental insults during early life that impact fetal programming, ultimately contributing to MetS in adulthood...
February 28, 2024: Nutrients
https://read.qxmd.com/read/38461803/comparison-of-anthropometric-metabolic-and-body-compositional-abnormalities-in-korean-children-and-adolescents-born-small-appropriate-and-large-for-gestational-age-a-population-based-study-from-knhanes-v-2010-2011
#4
JOURNAL ARTICLE
Tae Kwan Lee, Yoo Mi Kim, Han Hyuk Lim
PURPOSE: The impacts of growth restriction and programming in the fetal stage on metabolic and bone health in children and adolescents are poorly understood. Moreover, there is insufficient evidence for the relationship between current growth status and metabolic components. Herein, we compared the growth status, metabolic and body compositions, and bone mineral density in Korean children and adolescents based on birth weight at gestational age. METHODS: We studied 1,748 subjects (272 small for gestational age [SGA], 1,286 appropriate for gestational age [AGA], and 190 large for gestational age [LGA]; 931 men and 817 women) aged 10-18 years from the Korean National Health and Nutrition Examination Survey (KNHANES) V (2010-2011)...
February 2024: Annals of Pediatric Endocrinology & Metabolism
https://read.qxmd.com/read/38434579/the-fascinating-theory-of-fetal-programming-of-adult-diseases-a-review-of-the-fundamentals-of-the-barker-hypothesis
#5
JOURNAL ARTICLE
Gavino Faa, Vassilios Fanos, Mirko Manchia, Peter Van Eyken, Jasjit S Suri, Luca Saba
The theory of fetal programming of adult diseases was first proposed by David J.P. Barker in the eighties of the previous century, to explain the higher susceptibility of some people toward the development of ischemic heart disease. According to his hypothesis, poor maternal living conditions during gestation represent an important risk factor for the onset of atherosclerotic heart disease later in life. The analysis of the early phases of fetal development is a fundamental tool for the risk stratification of children and adults, allowing the identification of susceptible or resistant subjects to multiple diseases later in life...
January 2024: Journal of Public Health Research
https://read.qxmd.com/read/38396620/evaluation-of-muscle-long-non-coding-rna-profile-during-rearing-and-finishing-phase-of-bulls-subjected-to-different-prenatal-nutritional-strategies
#6
JOURNAL ARTICLE
Roberta Cavalcante Cracco, Pamela Almeida Alexandre, Guilherme Henrique Gebim Polizel, Arícia Christofaro Fernandes, Miguel Henrique de Almeida Santana
Maternal nutrition has the ability of influence critical processes in fetal life, including muscle development. Also, in this period, epigenetic sensitivity to external stimuli is higher and produces long-lasting effects. Thus, the aim of this study was to investigate epigenetic mechanisms, including the identification and characterization of long non-coding RNA (lncRNA) from animals that had undergone different strategies of prenatal supplementation. A group of Nellore cows (n = 126) were separated into three nutritional plans: NP (control)-Not Programmed, without protein-energy supplementation; PP-Partially Programmed, protein-energy supplementation in the final third of pregnancy; and CP-Complete Programming, protein-energy supplementation during the full period of gestation...
February 18, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38377153/prenatal-exposure-to-social-adversity-and-infant-cortisol-in-the-first-year-of-life
#7
JOURNAL ARTICLE
Victoria F Keeton, Thomas J Hoffmann, Kalisha Moneé Goodwin, Bree Powell, Sophia Tupuola, Sandra J Weiss
Exposure to social adversity has been associated with cortisol dysregulation during pregnancy and in later childhood; less is known about how prenatal exposure to social stressors affects postnatal cortisol of infants. In a secondary analysis of data from a longitudinal study, we tested whether a pregnant woman's reports of social adversity during the third trimester were associated with their infant's resting cortisol at 1, 6, and 12 months postnatal. Our hypothesis was that prenatal exposure to social adversity would be associated with elevation of infants' cortisol...
January 2024: Stress: the International Journal on the Biology of Stress
https://read.qxmd.com/read/38373508/interplay-between-maternal-nutrition-and-epigenetic-programming-on-offspring-hypertension
#8
REVIEW
You-Lin Tain, Chien-Ning Hsu
Recent human and animal studies have delineated hypertension can develop in the earliest stage of life. A lack or excess of particular nutrients in the maternal diet may impact the expression of genes associated with BP, leading to an increased risk of hypertension in adulthood. Modulations in gene expression could be caused by epigenetic mechanisms through aberrant DNA methylation, histone modification, and microRNAs (miRNAs). Several molecular mechanisms for the developmental programming of hypertension, including oxidative stress, dysregulated nutrient-sensing signal, aberrant renin-angiotensin system, and dysbiotic gut microbiota have been associated with epigenetic programming...
February 17, 2024: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/38337626/sex-dependent-variations-in-hypothalamic-fatty-acid-profile-and-neuropeptides-in-offspring-exposed-to-maternal-obesity-and-high-fat-diet
#9
JOURNAL ARTICLE
Mayara da Nóbrega Baqueiro, Laís Angélica de Paula Simino, João Paulo Costa, Carolina Panzarin, Andressa Reginato, Marcio Alberto Torsoni, Letícia Ignácio-Souza, Marciane Milanski, Michael G Ross, Kelly Pereira Coca, Mina Desai, Adriana Souza Torsoni
Maternal obesity and/or high-fat diet (HF) consumption can disrupt appetite regulation in their offspring, contributing to transgenerational obesity and metabolic diseases. As fatty acids (FAs) play a role in appetite regulation, we investigated the maternal and fetal levels of FAs as potential contributors to programmed hyperphagia observed in the offspring of obese dams. Female mice were fed either a control diet (CT) or HF prior to mating, and fetal and maternal blood and tissues were collected at 19 days of gestation...
January 24, 2024: Nutrients
https://read.qxmd.com/read/38282972/perspective-science-and-the-future-of-livestock-industries
#10
REVIEW
Graeme B Martin
Since the 1990s, livestock industries have been forced to respond to major pressures from society, particularly with respect to methane emissions and animal welfare. These challenges are exacerbated by the inevitability of global heating and the effects it will have on livestock productivity. The same challenges also led to questions about the value of animal-sourced foods for feeding the world. The industries and the research communities supporting them are meeting those challenges. For example, we can now envisage solutions to the ruminant methane problem and those solutions will also improve the efficiency of meat and milk production...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38282608/nutrition-during-pregnancy-influence-on-the-gut-microbiome-and-fetal-development
#11
REVIEW
Gabriela Barrientos, Francesca Ronchi, Melanie L Conrad
Pregnancy is a finely tuned process, with the health and well-being of the developing fetus determined by the metabolic status and dietary intake of the mother. The maternal gut microbiome is remodeled during pregnancy, and this, coupled with the maternal nutrient intake during gestation shapes the production of metabolites that can cross the placenta and affect fetal development. As posited by the Developmental Origins of Health and Disease Hypothesis, such environmental influences can have major effects on the developing organ systems...
January 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38276803/evidence-based-eating-patterns-and-behavior-changes-to-limit-excessive-gestational-weight-gain-a-scoping-review
#12
REVIEW
Kiley Ketchum, Cecilia M Jevitt
BACKGROUND: International prenatal care guidelines set a standard for clinicians to discuss gestational weight gain with their patients along with the complications associated with prepregnancy obesity and excessive gestational weight gain. Clinicians often lack evidence-based eating, nutrition, and activity strategies to share with patients. METHODS: This systematic review aimed to find eating patterns and behaviors that could be used safely during pregnancy to limit excessive gestational weight gain...
December 21, 2023: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38276566/maternal-lutein-intake-during-pregnancies-with-or-without-gestational-diabetes-mellitus-and-cognitive-development-of-children-at-2-years-of-age-a-prospective-observational-study
#13
JOURNAL ARTICLE
Isma'il Kadam, Chauntelle Nebie, Mudar Dalloul, Joan Hittelman, Lawrence Fordjour, Lori Hoepner, Itamar D Futterman, Howard Minkoff, Xinyin Jiang
Lutein and its isomer zeaxanthin serve as antioxidants and preserve cognitive function during aging. However, whether lutein/zeaxanthin (L + Z) exposure early in life improves cognitive development of children is rarely explored. It is also unknown whether gestational diabetes mellitus (GDM), characterized by heightened oxidative stress, affects lutein metabolism. This prospective longitudinal cohort study examined the differences in L + Z intake and metabolism, as well as the association between maternal L + Z intake and children's cognitive development in GDM versus non-GDM pregnancies...
January 22, 2024: Nutrients
https://read.qxmd.com/read/38276547/fructose-consumption-affects-placental-production-of-h-2-s-impact-on-preeclampsia-related-parameters
#14
JOURNAL ARTICLE
Madelín Pérez-Armas, Elena Fauste, Cristina Donis, Silvia Rodrigo, Lourdes Rodríguez, Juan J Álvarez-Millán, María I Panadero, Paola Otero, Carlos Bocos
H2 S, a gasotransmitter that can be produced both via the transsulfuration pathway and non-enzymatically, plays a key role in vasodilation and angiogenesis during pregnancy. In fact, the involvement of H2 S production on plasma levels of sFLT1, PGF, and other molecules related to preeclampsia has been demonstrated. Interestingly, we have found that maternal fructose intake (a common component of the Western diet) affects tissular H2 S production. However, its consumption is allowed during pregnancy. Thus, (1) to study whether maternal fructose intake affects placental production of H2 S in the offspring, when pregnant; and (2) to study if fructose consumption during pregnancy can increase the risk of preeclampsia, pregnant rats from fructose-fed mothers (10% w / v ) subjected (FF) or not (FC) to a fructose supplementation were studied and compared to pregnant control rats (CC)...
January 20, 2024: Nutrients
https://read.qxmd.com/read/38248812/metabolomics-changes-in-meat-and-subcutaneous-fat-of-male-cattle-submitted-to-fetal-programming
#15
JOURNAL ARTICLE
Arícia Christofaro Fernandes, Guilherme Henrique Gebim Polizel, Roberta Cavalcante Cracco, Fernando Augusto Correia Queiroz Cançado, Geovana Camila Baldin, Mirele Daiana Poleti, José Bento Sterman Ferraz, Miguel Henrique de Almeida Santana
This study investigated changes in meat and subcutaneous fat metabolomes and possible metabolic pathways related to prenatal nutrition in beef cattle. For this purpose, 18 Nellore bulls were used for meat sampling and 15 for fat sampling. The nutritional treatments during the gestation were: NP-not programmed or control, without protein-energy supplementation; PP-partially programmed, with protein-energy supplementation (0.3% of body weight (BW)) only in the final third of pregnancy; and FP-full programming, with protein-energy supplementation (0...
December 22, 2023: Metabolites
https://read.qxmd.com/read/38201877/impact-of-maternal-mediterranean-type-diet-adherence-on-microbiota-composition-and-epigenetic-programming-of-offspring
#16
JOURNAL ARTICLE
Tamlyn Sasaki, Megan Kawamura, Chirstyn Okuno, Kayleen Lau, Jonathan Riel, Men-Jean Lee, Corrie Miller
Understanding how maternal diet affects in utero neonatal gut microbiota and epigenetic regulation may provide insight into disease origins and long-term health. The impact of Mediterranean diet pattern adherence (MDA) on fetal gut microbiome and epigenetic regulation was assessed in 33 pregnant women. Participants completed a validated food frequency questionnaire in each trimester of pregnancy; the alternate Mediterranean diet (aMED) score was applied. Umbilical cord blood, placental tissue, and neonatal meconium were collected from offspring...
December 22, 2023: Nutrients
https://read.qxmd.com/read/38198718/fetal-programming-effect-of-rumen-protected-methionine-on-primiparous-angus-%C3%A3-simmental-offspring-s-performance-and-skeletal-muscle-gene-expression
#17
JOURNAL ARTICLE
Gastón F Alfaro, Soren Rodning, Sonia Moisá
Primiparous Angus × Simmental dams (n = 22) with average body weight of 449 ± 32 kg of body weight were divided based on two nutritional treatments: control (CTRL) and rumen-protected methionine (RPM). Control group received bermudagrass hay, and corn gluten and soybean hulls pellets supplementation (base diet); whereas RPM group received the base diet in addition to 0.07 % of DM of RPM at a fixed rate during the last trimester of gestation and the first ~ 80 days of lactation, in which calves (n = 17) were early weaned...
January 10, 2024: Journal of Animal Science
https://read.qxmd.com/read/38195352/early-life-exposure-to-gestational-diabetes-mellitus-predisposes-offspring-to-pediatric-nonalcoholic-fatty-liver-disease
#18
REVIEW
Qian-Ren Zhang, Yan Dong, Jian-Gao Fan
Nonalcoholic fatty liver disease (NAFLD) has emerged as the prevailing chronic liver disease in the pediatric population due to the global obesity pandemic. Evidence shows that prenatal and postnatal exposure to maternal abnormalities leads to a higher risk of pediatric NAFLD through persistent alterations in developmental programming. Gestational diabetes mellitus (GDM) is a hyperglycemic syndrome which has become the most prevalent complication in pregnant women. An increasing number of both epidemiologic investigations and animal model studies have validated adverse and long-term outcomes in offspring following GDM exposure in utero...
December 30, 2023: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38181968/adverse-metabolic-phenotypes-in-parenterally-fed-neonatal-pigs-do-not-persist-into-adolescence
#19
JOURNAL ARTICLE
Sarah K Elefson, Barbara Stoll, Teresa A Davis, Marta L Fiorotto, Samer W El Kadi, Kenneth Genovese, Thomas Thymann, Per T Sangild, Douglas G Burrin
BACKGROUND: Nutrition during fetal and neonatal life is an important determinant for the risk of adult-onset diseases, especially Type 2 diabetes and obesity. OBJECTIVE: Our aim was to determine whether total parenteral nutrition (TPN) vs. enteral formula feeding (EN) in term piglets during the first 2 weeks after birth would increase the long-term (5-month) development of metabolic syndrome phenotypes with adverse glucose homeostasis, fatty liver disease, and obesity...
January 3, 2024: Journal of Nutrition
https://read.qxmd.com/read/38137473/the-impact-of-maternal-obesity-on-adipose-progenitor-cells
#20
REVIEW
Simon Lecoutre, Salwan Maqdasy, Mélanie Lambert, Christophe Breton
The concept of Developmental Origin of Health and Disease (DOHaD) postulates that adult-onset metabolic disorders may originate from suboptimal conditions during critical embryonic and fetal programming windows. In particular, nutritional disturbance during key developmental stages may program the set point of adiposity and its associated metabolic diseases later in life. Numerous studies in mammals have reported that maternal obesity and the resulting accelerated growth in neonates may affect adipocyte development, resulting in persistent alterations in adipose tissue plasticity (i...
December 8, 2023: Biomedicines
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