Madelín Pérez-Armas, Elena Fauste, Cristina Donis, Silvia Rodrigo, Lourdes Rodríguez, Juan J Álvarez-Millán, María I Panadero, Paola Otero, Carlos Bocos
H2 S, a gasotransmitter that can be produced both via the transsulfuration pathway and non-enzymatically, plays a key role in vasodilation and angiogenesis during pregnancy. In fact, the involvement of H2 S production on plasma levels of sFLT1, PGF, and other molecules related to preeclampsia has been demonstrated. Interestingly, we have found that maternal fructose intake (a common component of the Western diet) affects tissular H2 S production. However, its consumption is allowed during pregnancy. Thus, (1) to study whether maternal fructose intake affects placental production of H2 S in the offspring, when pregnant; and (2) to study if fructose consumption during pregnancy can increase the risk of preeclampsia, pregnant rats from fructose-fed mothers (10% w / v ) subjected (FF) or not (FC) to a fructose supplementation were studied and compared to pregnant control rats (CC)...
January 20, 2024: Nutrients