keyword
https://read.qxmd.com/read/37988912/therapeutic-potential-of-a-synthetic-dual-jak1-tyk2-inhibitor-in-inflammatory-bowel-disease
#1
JOURNAL ARTICLE
Xue Cui, Yaxin Teng, Yiguo Hu, Qingqing Li, Heying Pei, Zhuang Yang
Inflammatory bowel disease (IBD) is a chronic and incurable disease with an increasing incidence rate and low mortality rate. Selectively inhibiting JAK1 and TYK2 has been proposed as a strategy to enhance the efficacy of such inhibitors while minimizing the potential side effects on other JAK isoforms. Our previous studies identified small molecule 18 as a JAK1/TYK2 inhibitor with high selectivity and a new structure. Specifically, the IC50 of 18 at the kinase level reached 39 nM and 21 nM for JAK1 and TYK2, respectively, with 10-fold selectivity over both JAK2 and JAK3...
November 20, 2023: International Immunopharmacology
https://read.qxmd.com/read/37984469/tregs-protect-against-invariant-nkt-cell-mediated-autoimmune-colitis-and-hepatitis
#2
JOURNAL ARTICLE
Koen Venken, Tine Decruy, Tim Sparwasser, Dirk Elewaut
Immunomodulatory T cells play a pivotal role in protection against (auto)immune-mediated diseases that open perspectives for therapeutic modulation. However, how immune regulatory networks operate in vivo is less understood. To this end, we focused on FOXP3+CD4+CD25+ regulatory T cells (Tregs) and invariant natural killer T (iNKT) cells, two lymphocyte populations that independently regulate adaptive and innate immune responses. In vitro, a functional interplay between Tregs and iNKT cells has been described, but whether Tregs modulate the function and phenotype of iNKT cell subsets in vivo and whether this controls iNKT-mediated autoimmunity is unclear...
November 20, 2023: Immunology
https://read.qxmd.com/read/37902927/management-of-ulcerative-colitis-by-dichloroacetate-impact-on-nfatc1-nlrp3-il1b-signaling-based-on-bioinformatics-analysis-combined-with-in-vivo-experimental-verification
#3
JOURNAL ARTICLE
Esraa Abdel-Nassir Abdel-Razek, Heba M Mahmoud, Amany A Azouz
The inflammatory response in ulcerative colitis (UC) could be relieved by the conventional immunomodulatory agents; 5-aminosalicylic acid, corticosteroids, or azathioprine. However, the low remission rates and the intolerance to these agents necessitate investigation of gene expression signature in UC that could influence the therapeutic efficacy of drugs, as well as the interference with persistence genes by novel therapeutic option. Three microarray datasets (GSE66407, GSE38713 and GSE14580) from the NCBI-GEO database were utilized...
October 30, 2023: Inflammopharmacology
https://read.qxmd.com/read/36824172/structural-properties-and-anti-inflammatory-activity-of-purified-polysaccharides-from-hen-of-the-woods-mushrooms-grifola-frondosa
#4
JOURNAL ARTICLE
Xiaoyi Liu, Shuai Chen, Huijuan Liu, Jiao Xie, K M Faridul Hasan, Qibing Zeng, Shaofeng Wei, Peng Luo
Grifola frondosa is an edible medicinal mushroom that has been proven to have a variety of health benefits. The main active ingredients of this mushroom are polysaccharides. In this study, ultrasonic-assisted extraction was used to obtain crude Grifola frondosa polysaccharides (GFPs). Then, purified GFP was obtained after purification. The optimum extraction conditions were an extraction time of 71 min, an extraction temperature of 90°C in a solid-to-liquid ratio of 1:37 g/mL, and an ultrasonic power of 500 W...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/36769034/moderating-gut-microbiome-mitochondrial-axis-in-oxazolone-induced-ulcerative-colitis-the-evolving-role-of-%C3%AE-glucan-and-or-aldose-reductase-inhibitor-fidarestat
#5
JOURNAL ARTICLE
Omnia Safwat El-Deeb, Rasha Osama Elesawy, Amira K Eltokhy, Hanan Alsaeid Al-Shenawy, Heba Bassiony Ghanem, Fatma H Rizk, Ramez Ae Barhoma, Rania H Shalaby, Amal M Abdelsattar, Shaimaa S Mashal, Kareman Ahmed Eshra, Radwa Mahmoud El-Sharaby, Dina Adam Ali, Rowida Raafat Ibrahim
A mechanistic understanding of the dynamic interactions between the mitochondria and the gut microbiome is thought to offer innovative explanations for many diseases and thus provide innovative management approaches, especially in GIT-related autoimmune diseases, such as ulcerative colitis (UC). β-Glucans, important components of many nutritious diets, including oats and mushrooms, have been shown to exhibit a variety of biological anti-inflammatory and immune-modulating actions. Our research study sought to provide insight into the function of β-glucan and/or fidarestat in modifying the microbiome/mitochondrial gut axis in the treatment of UC...
January 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36768979/differential-roles-of-cystathionine-gamma-lyase-and-mercaptopyruvate-sulfurtransferase-in-hapten-induced-colitis-and-contact-dermatitis-in-mice
#6
JOURNAL ARTICLE
Noriyuki Akahoshi, Ryoka Hasegawa, Shingo Yamamoto, Rintaro Takemoto, Toshiki Yoshizawa, Waka Kamichatani, Isao Ishii
Hydrogen sulfide (H2 S) has been shown to act as both anti-inflammatory and pro-inflammatory mediators. Application of H2 S donors generally protects against inflammation; however, experimental results using mice lacking endogenous H2 S-producing enzymes, such as cystathionine γ-lyase (CTH) and mercaptopyruvate sulfurtransferase (MPST), are often contradictory. We herein examined two types of model hapten-induced inflammation models, colitis (an inflammatory bowel disease model of mucosal immunity) and contact dermatitis (a type IV allergic model of systemic immunity), in CTH-deficient ( Cth -/- ) and MPST-deficient ( Mpst -/- ) mice...
January 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36634827/f4-80-ly6c-high-macrophages-lead-to-cell-plasticity-and-cancer-initiation-in-colitis
#7
JOURNAL ARTICLE
Alice E Shin, Yodit Tesfagiorgis, Frederikke Larsen, Mathieu Derouet, Peter Y F Zeng, Hayley J Good, Liyue Zhang, Mara R Rubinstein, Yiping W Han, Steven M Kerfoot, Anthony C Nichols, Yoku Hayakawa, Christopher J Howlett, Timothy C Wang, Samuel Asfaha
BACKGROUND & AIMS: Colorectal cancer is a leading cause of cancer death, and a major risk factor is chronic inflammation. Despite the link between colitis and cancer, the mechanism by which inflammation leads to colorectal cancer is not well understood. METHODS: To investigate whether different forms of inflammation pose the same risk of cancer, we compared several murine models of colitis (dextran sodium sulfate [DSS], 2,4,6-trinitrobenzene sulfonic acid, 4-ethoxylmethylene-2-phenyloxazol-5-one, Citrobacter rodentium, Fusobacterium nucleatum, and doxorubicin) with respect to their ability to lead to colonic tumorigenesis...
April 2023: Gastroenterology
https://read.qxmd.com/read/36118767/elucidation-of-physicochemical-properties-of-polysaccharides-extracted-from-cordyceps-militaris-fruiting-bodies-with-different-drying-treatments-and-their-effects-on-ulcerative-colitis-in-zebrafish
#8
JOURNAL ARTICLE
Yin Wei, Xiao Du, Yangbian Guo, Mingchang Chang, Bing Deng, Jingyu Liu, Jinling Cao
Dry fruiting bodies of Cordyceps militaris (CMF) have been widely used in folk tonic foods and traditional herbal medicine in East Asia. Drying treatment serves as the last step in CMF industrial processes. In this work, the physicochemical properties of polysaccharides from C. militaris fruiting bodies (CMFPs) with hot air drying (HD), far-infrared radiation drying (ID) and vacuum freeze-drying (FD) treatments were analyzed, and their effects on ulcerative colitis (UC) were further investigated in oxazolone-induced zebrafish...
2022: Frontiers in Nutrition
https://read.qxmd.com/read/36090686/restorative-effects-of-rg3-enriched-korean-red-ginseng-and-persicaria-tinctoria-extract-on-oxazolone-induced-ulcerative-colitis-in-mice
#9
JOURNAL ARTICLE
H M Arif Ullah, Evelyn Saba, Yuan Yee Lee, Seung-Bok Hong, Sun-Hee Hyun, Yi-Seong Kwak, Chae-Kyu Park, Sung Dae Kim, Man Hee Rhee
Background: Ulcerative colitis (UC) is the large intestine disease that results in chronic inflammation and ulcers in the colon. Rg3-enriched Korean Red Ginseng extract (Rg3-RGE) is known for its pharmacological activities. Persicaria tinctoria (PT) is also used in the treatment of various inflammatory diseases. The aim of this study is to investigate the attenuating effects of Rg3-RGE with PT on oxazolone (OXA)-induced UC in mice. Methods: A total of six groups of mice including control group, OXA (as model group, 1...
September 2022: Journal of Ginseng Research
https://read.qxmd.com/read/36032134/glucocorticoid-induced-group-2-innate-lymphoid-cell-overactivation-exacerbates-experimental-colitis
#10
JOURNAL ARTICLE
Bingcheng Feng, Lin Lin, Lixiang Li, Xin Long, Chao Liu, Zixiao Zhao, Shiyang Li, Yanqing Li
Abnormal activation of the innate and adaptive immune systems has been observed in inflammatory bowel disease (IBD) patients. Anxiety and depression increase the risk of IBD by activating the adaptive immune system. However, whether anxiety affects innate immunity and its impact on IBD severity remains elusive. This study investigated the mechanism by which anxiety contributes to IBD development in a murine model of acute wrap restraint stress (WRS). Here, we found that anxiety-induced overactivation of group 2 innate lymphoid cells (ILC2) aggravated colonic inflammation...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36012618/inflammatory-bowel-disease-a-review-of-pre-clinical-murine-models-of-human-disease
#11
REVIEW
Brunette Katsandegwaza, William Horsnell, Katherine Smith
Crohn's disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although the cause of IBD is still unclear, several experimental IBD murine models have enabled researchers to make great inroads into understanding human IBD pathology. Here, we discuss the current pre-clinical experimental murine models for human IBD, including the chemical-induced trinitrobenzene sulfonic acid (TNBS) model, oxazolone and dextran sulphate sodium (DSS) models, the gene-deficient I-kappa-B kinase gamma (Iκκ-γ) and interleukin(IL)-10 models, and the CD4+ T-cell transfer model...
August 19, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35917251/a-protective-role-of-nod2-on-oxazolone-induced-intestinal-inflammation-through-il-1%C3%AF-mediated-signaling-pathway
#12
JOURNAL ARTICLE
Thomas Secher, Aurélie Couturier, Ludovic Huot, Helene Bouscayrol, Teddy Grandjean, Olivier Boulard, David Hot, Bernhard Ryffel, Mathias Chamaillard
BACKGROUND AND AIMS: NOD2 has emerged as a critical player in the induction of both Th1- and Th2-responses for potentiation and polarization of antigen-dependent immunity. Loss-of-function mutations in the NOD2-encoding gene and deregulation of its downstream signaling pathway have been linked to Crohn's disease. While it is well documented that NOD2 is capable of sensing bacterial muramyl dipeptide, it remains counterintuitive to link development of overt intestinal inflammation to a loss of bacterial-induced inflammatory response...
August 2, 2022: Journal of Crohn's & Colitis
https://read.qxmd.com/read/35877196/basophils-play-a-proinflammatory-role-in-oxazolone-induced-chronic-intestinal-inflammation
#13
JOURNAL ARTICLE
Kenichi Inaba, Masaaki Higashiyama, Chikako Watanabe, Akira Tomioka, Suguru Ito, Rina Tanemoto, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi, Yoshihiro Akita, Yoshikiyo Okada, Chie Kurihara, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Hajime Karasuyama, Takahiro Satoh, Ryota Hokari
INTRODUCTION: The functions of basophils have not been elucidated until recently because of their rarity. However, with recent developments in basophil-specific antibodies and basophil-deficient animals, the roles of basophils in various diseases related to chronic inflammation have been clarified. In this study, we aimed to investigate the roles of basophils in human ulcerative colitis (UC) and oxazolone (OXA) colitis using genetically engineered Mcpt8DTR mice. METHODS: Immunohistochemical staining of human colon specimens was performed to examine the involvement of basophils in the pathogenesis of UC...
July 25, 2022: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/35699622/label-free-characterization-and-quantification-of-mucosal-inflammation-in-common-murine-colitis-models-with-multiphoton-imaging
#14
JOURNAL ARTICLE
Lucas Kreiss, Oana-Maria Thoma, Sarah Lemire, Kristina Lechner, Birgitta Carlé, Ashwathama Dilipkumar, Timo Kunert, Kristina Scheibe, Christina Heichler, Anna-Lena Merten, Benno Weigmann, Clemens Neufert, Kai Hildner, Michael Vieth, Markus F Neurath, Oliver Friedrich, Sebastian Schürmann, Maximilian J Waldner
BACKGROUND: Clinical challenges in inflammatory bowel diseases require microscopic in vivo evaluation of inflammation. Here, label-free imaging holds great potential, and recently, our group demonstrated the advantage of using in vivo multiphoton endomicroscopy for longitudinal animal studies. This article extends our previous work by in-depth analysis of label-free tissue features in common colitis models quantified by the multiphoton colitis score (MCS). METHODS: Fresh mucosal tissues were evaluated from acute and chronic dextran sulfate sodium (DSS), TNBS, oxazolone, and transfer colitis...
June 14, 2022: Inflammatory Bowel Diseases
https://read.qxmd.com/read/35622259/influence-of-rectal-ozone-application-on-the-intensity-of-free-radical-destruction-of-lipids-and-intestinal-proteins-in-the-dynamics-of-experimental-colitis
#15
JOURNAL ARTICLE
M V Osikov, E V Davydova, N V Kaigorodtseva, A A Fedosov, M A Il'inykh, K S Savchuk, L V Vorgova
We studied clinical status, content of products of LPO, and oxidative modification of proteins (OMP) in the lesion focus of the intestine in experimental colitis under conditions of rectal administration of ozone. Experimental colitis was simulated by two-stage administration of oxazolone; rectal insufflation of ozone in the ozone-oxygen mixture was performed daily. The disease activity index (DAI), the content of calprotectin in the feces, and LPO and OMP products in the intestinal homogenate were assessed...
May 2022: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/35103289/pulsatilla-decoction-alleviates-colitis-by-enhancing-autophagy-and-regulating-pi3k%C3%A2-akt%C3%A2-mtorc1-signaling-pathway
#16
JOURNAL ARTICLE
Xuewei Wang, Lijun Xu, Tao Wang, Jian Xu, Fugang Fan, Yu Zhang, Jinpin Wang, Qin Cao
The aim of the present study was to investigate the therapeutic effect of Pulsatilla decoction (PD) on ulcerative colitis (UC) and to elucidate its potential molecular mechanisms. C57BL/6 mice expressing natural killer (NK)1.1 were used as experimental animals in the present study and a model of oxazolone‑induced colitis was established. Mice were randomly divided into the following five groups: i) PD group; ii) oxazolone‑induced colitis group; iii) IL‑13 intervention group; iv) 5‑aminosalicylic acid positive control group; and v) negative control group (equal volume saline gavage)...
March 2022: Molecular Medicine Reports
https://read.qxmd.com/read/34997096/cholinergic-anti-inflammatory-pathway-ameliorates-murine-experimental-th2-type-colitis-by-suppressing-the-migration-of-plasmacytoid-dendritic-cells
#17
JOURNAL ARTICLE
Yuya Kanauchi, Takeshi Yamamoto, Minako Yoshida, Yue Zhang, Jaemin Lee, Shusaku Hayashi, Makoto Kadowaki
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Several studies have demonstrated that α7 nicotinic acetylcholine receptors (α7nAChRs) exert anti-inflammatory effects on immune cells and nicotine suppress UC onset and relapse. Plasmacytoid dendritic cells (pDCs) reportedly accumulate in the colon of UC patients. Therefore, we investigated the pathophysiological roles of α7nAChRs on pDCs in the pathology of UC using oxazolone (OXZ)-induced Th2-type colitis with BALB/c mice. 2-deoxy-D-glucose, a central vagal stimulant suppressed OXZ colitis, and nicotine also ameliorated OXZ colitis with suppressing Th2 cytokines, which was reversed by α7nAChR antagonist methyllycaconitine...
January 7, 2022: Scientific Reports
https://read.qxmd.com/read/34461283/activated-mucosal-associated-invariant-t-cells-have-a-pathogenic-role-in-a-murine-model-of-inflammatory-bowel-disease
#18
JOURNAL ARTICLE
Yusuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Sachiko Miyake
BACKGROUND & AIMS: Mucosal-associated invariant T (MAIT) cells are innate-like T cells restricted by major histocompatibility complex-related molecule 1 (MR1) and express a semi-invariant T cell receptor. Previously, we reported the activation status of circulating MAIT cells in patients with ulcerative colitis (UC) was associated with disease activity and that these cells had infiltrated the inflamed colonic mucosa. These findings suggest MAIT cells are involved in the pathogenesis of inflammatory bowel disease...
2022: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/34324951/limonene-from-agastache-mexicana-essential-oil-produces-antinociceptive-effects-gastrointestinal-protection-and-improves-experimental-ulcerative-colitis
#19
COMPARATIVE STUDY
González-Ramírez Adriana Estrella, González-Trujano María Eva, Hernandez-Leon Alberto, Valle-Dorado María Guadalupe, Carballo-Villalobos Azucena, Orozco-Suárez Sandra, Alvarado-Vásquez Noé, López-Muñoz Francisco Javier
ETHNOPHARMACOLOGY RELEVANCE: Agastache mexicana is a popular plant of great demand in folk medicine, essentially due to its calming properties and for alleviating arthritic, muscular and abdominal pain. Despite its spectrum for pain relief, pharmacological studies of its bioactive constituents have been barely investigated. AIM OF THE STUDY: To evaluate protective properties of the A. mexicana and bioactive compounds improving pathological gastrointestinal conditions in rodents...
November 15, 2021: Journal of Ethnopharmacology
https://read.qxmd.com/read/34260310/persistence-of-lgr5-colonic-epithelial-stem-cells-in-mouse-models-of-inflammatory-bowel-disease
#20
JOURNAL ARTICLE
Nandini Girish, Cambrian Y Liu, Safina Gadeock, Marie L Gomez, Ying Huang, Zohreh Sharifkhodaei, M Kay Washington, D Brent Polk
Intestinal mucosal healing is the primary therapeutic goal of medical treatments for inflammatory bowel disease (IBD). Epithelial stem cells are key players in the healing process. Lgr5+ stem cells maintain cellular turnover during homeostasis in the colonic crypt. However, they are lost and dispensable for repair in a wide variety of injury models, including dextran sulfate sodium (DSS) colitis, radiation, helminth infection, and T-cell activation. The direct loss of Lgr5+ cells activates a plasticity response in the epithelium in which other cell types can serve as stem cells...
September 1, 2021: American Journal of Physiology. Gastrointestinal and Liver Physiology
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