Kenichi Inaba, Masaaki Higashiyama, Chikako Watanabe, Akira Tomioka, Suguru Ito, Rina Tanemoto, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi, Yoshihiro Akita, Yoshikiyo Okada, Chie Kurihara, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Hajime Karasuyama, Takahiro Satoh, Ryota Hokari
INTRODUCTION: The functions of basophils have not been elucidated until recently because of their rarity. However, with recent developments in basophil-specific antibodies and basophil-deficient animals, the roles of basophils in various diseases related to chronic inflammation have been clarified. In this study, we aimed to investigate the roles of basophils in human ulcerative colitis (UC) and oxazolone (OXA) colitis using genetically engineered Mcpt8DTR mice. METHODS: Immunohistochemical staining of human colon specimens was performed to examine the involvement of basophils in the pathogenesis of UC...
July 25, 2022: Journal of Gastroenterology and Hepatology