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Dopamine transients

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https://www.readbyqxmd.com/read/29324402/c-fscv-compressive-fast-scan-cyclic-voltammetry-for-brain-dopamine-recording
#1
Hossein Zamani, Hamid Reza Bahrami, Preeti Chalwadi, Paul A Garris, Pedram Mohseni
This paper presents a novel compressive sensing framework for recording brain dopamine levels with fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode. Termed compressive FSCV (C-FSCV), this approach compressively samples the measured total current in each FSCV scan and performs basic FSCV processing steps, e.g., background current averaging and subtraction, directly with compressed measurements. The resulting background-subtracted faradaic currents, which are shown to have a block-sparse representation in the discrete cosine transform domain, are next reconstructed from their compressively sampled counterparts with the block sparse Bayesian learning algorithm...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29321525/exploring-the-consequences-of-social-defeat-stress-and-intermittent-ethanol-drinking-on-dopamine-dynamics-in-the-rat-nucleus-accumbens
#2
Alex L Deal, Joanne K Konstantopoulos, Jeff L Weiner, Evgeny A Budygin
The current study aimed to explore how presynaptic dopamine (DA) function is altered following brief stress episodes and chronic ethanol self-administration and whether these neuroadaptations modify the acute effects of ethanol on DA dynamics. We used fast-scan cyclic voltammetry to evaluate changes in DA release and uptake parameters in rat nucleus accumbens brain slices by analyzing DA transients evoked through single pulse electrical stimulation. Adult male rats were divided into four groups: ethanol-naïve or ethanol drinking (six week intermittent two-bottle choice) and stressed (mild social defeat) or nonstressed...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313985/cart-peptide-in-the-nucleus-accumbens-shell-inhibits-cocaine-induced-locomotor-sensitization-to-transient-overexpression-of-%C3%AE-ca2-calmodulin-dependent-protein-kinase-ii
#3
Lixia Xiong, Qing Meng, Xi Sun, Xiangtong Lu, Qiang Fu, Qinghua Peng, Jianhua Yang, Ki-Wan Oh, Zhen Zhen Hu
Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter that attenuates cocaine-induced locomotor activity when injected into the nucleus accumbens (NAc). Our previous work first confirmed that the inhibitory mechanism of the CART peptide on cocaine-induced locomotor activity is related to a reduction in cocaine-enhanced phosphorylated Ca2+ /calmodulin-dependent protein kinaseIIα (pCaMKIIα) and the enhancement of cocaine-induced D3R function. The present study investigated whether CART peptide inhibited cocaine-induced locomotor activity via inhibition of interactions between pCaMKIIα and the D3 dopamine receptor (D3R)...
January 4, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29305987/l-3-4-dihydroxyphenylalanine-l-dopa-induces-neuroendocrinological-physiological-and-immunological-regulation-in-white-shrimp-litopenaeus-vannamei
#4
Ratchaneegorn Mapanao, Hsin-Wei Kuo, Chin-Chuan Chang, Kuan-Fu Liu, Winton Cheng
L-3,4-Dihydroxyphenylalanine (l-DOPA) is a precursor for dopamine (DA) synthesis. Assessments were conducted to analyze the effects of l-DOPA on mediating regulation of neuroendocrinological, immunological, and physiological parameters in the shrimp, Litopenaeus vannamei when they were individually injected with 0.01 N HCl or l-DOPA at 0.5 or 1.0 μmol shrimp-1 for 60, 120, and 240 min. For catecholamine synthesis evaluation, tyrosine hydroxylase (TH) and DA beta hydroxylase (DBH) activities, l-DOPA, DA, and norepinephrine (NE) levels in hemolymph were determined...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29297512/the-protective-action-encoding-of-serotonin-transients-in-the-human-brain
#5
Rosalyn J Moran, Kenneth T Kishida, Terry Lohrenz, Ignacio Saez, Adrian W Laxton, Mark R Witcher, Stephen B Tatter, Thomas L Ellis, Paul Em Phillips, Peter Dayan, P Read Montague
The role of serotonin in human brain function remains elusive due, at least in part, to our inability to measure rapidly the local concentration of this neurotransmitter. We used fast-scan cyclic voltammetry to infer serotonergic signaling from the striatum of fourteen brains of human patients with Parkinson's disease. Here we report these novel measurements and show that they correlate with outcomes and decisions in a sequential investment game. We find that serotonergic concentrations transiently increase as a whole following negative reward prediction errors, while reversing when counterfactual losses predominate...
January 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29288665/intact-calcium-signaling-in-adrenergic-deficient-embryonic-mouse-hearts
#6
Jessica N Peoples, David G Taylor, Alexander N Katchman, Steven N Ebert
Mouse embryos that lack the ability to produce the adrenergic hormones, norepinephrine (NE) and epinephrine (EPI), due to disruption of the dopamine beta-hydroxylase (Dbh-/-) gene inevitably perish from heart failure during mid-gestation. Since adrenergic stimulation is well-known to enhance calcium signaling in developing as well as adult myocardium, and impairments in calcium signaling are typically associated with heart failure, we hypothesized that adrenergic-deficient embryonic hearts would display deficiencies in cardiac calcium signaling relative to adrenergic-competent controls at a developmental stage immediately preceding the onset of heart failure, which first appears beginning or shortly after mouse embryonic day 10...
December 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29261226/in-vitro-assays-for-the-functional-characterization-of-the-dopamine-transporter-dat
#7
Shaili Aggarwal, Ole V Mortensen
Detailed in this unit are protocols for studying the in vitro uptake of dopamine (DA) as a means for defining the functional characteristics of dopamine transporters. All assays are performed using commercially available cell lines that transiently express the transporter under investigation. The three main assays provided are: a kinetic assay to calculate the affinity (KM ) and maximal velocity (Vmax ) of radiolabeled DA uptake into cells; concentration-response assays to measure the potencies (IC50 /Ki values) of test compounds as transport inhibitors; and an efflux assay to assess the ability and potency (EC50 ) of a ligand to elicit reverse transport of DA accumulated in the cell...
December 20, 2017: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/29220863/a-small-dose-of-apomorphine-counteracts-the-deleterious-effects-of-middle-cerebral-artery-occlusion-in-different-models
#8
F Mastroiacovo, A Gaglione, C L Busceti, L Ryskalin, G Bozza, F Nicoletti, F Orzi, F Fornai
The present manuscript investigates in two animal species by using two different experimental models of middle cerebral artery occlusion (permanent and transient), the neuroprotective effects of the dopamine receptor agonist apomorphine. These effects were evaluated by measuring the infarct volume and by counting muscle strength at different time points following the ischemic insult. Apomorphine at the dose of 3 mg/Kg when adminsitered at two hours following the occlusion of the middle cerebral artery was able to reduce significantly the infarct volume in the cortex of mice and the ischemic volume of the basal ganglia perfused by the perforant branches of the middle cerebral artery in the rat...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29216597/role-of-dopamine-receptors-in-the-anticancer-activity-of-onc201
#9
Christina Leah B Kline, Marie D Ralff, Amriti R Lulla, Jessica M Wagner, Phillip H Abbosh, David T Dicker, Joshua E Allen, Wafik S El-Deiry
ONC201/TIC10 is a first-in-class small molecule inducer of TRAIL that causes early activation of the integrated stress response. Its promising safety profile and broad-spectrum efficacy in vitro have been confirmed in Phase I/II trials in several advanced malignancies. Binding and reporter assays have shown that ONC201 is a selective antagonist of the dopamine D2-like receptors, specifically, DRD2 and DRD3. We hypothesized that ONC201's interaction with DRD2 plays a role in ONC201's anticancer effects. Using cBioportal and quantitative reverse-transcription polymerase chain reaction analyses, we confirmed that DRD2 is expressed in different cancer cell types in a cell type-specific manner...
December 5, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29196318/inactivation-of-nmda-receptors-in-the-ventral-tegmental-area-during-cocaine-self-administration-prevents-glua1-up-regulation-but-with-paradoxical-increases-in-cocaine-seeking-behavior
#10
Daniel Guzman, Maria B Carreira, Allyson K Friedman, Megumi Adachi, Rachael L Neve, Lisa M Monteggia, Ming-Hu Han, Christopher W Cowan, David W Self
Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons that subsequently enhance the motivation for cocaine. This increase in GluA1 may be dependent on concomitant NMDA receptor (NMDAR) activation during self-administration, similar to cocaine-induced LTP in the VTA. In this study, we used viral-mediated expression of a dominant negative GluN1 subunit (HSV-dnGluN1) in VTA neurons to study the effect of transient NMDAR inactivation on the GluA1 increases induced by chronic cocaine self-administration in male rats...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29175028/17%C3%AE-estradiol-locally-increases-phasic-dopamine-release-in-the-dorsal-striatum
#11
Waqqas M Shams, Marie-Pierre Cossette, Peter Shizgal, Wayne G Brake
Studies using in vivo microdialysis have shown that 17β-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anesthetized (1.5mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum...
November 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29167404/a-critical-role-for-dopamine-d5-receptors-in-pain-chronicity-in-male-mice
#12
Salim Megat, Stephanie Shiers, Jamie K Moy, Paulino Barragan-Iglesias, Grishma Pradhan, Rebecca P Seal, Gregory Dussor, Theodore J Price
Dopaminergic modulation of spinal cord plasticity has long been recognized but circuits affected by this system and the precise receptor subtypes involved in this modulation have not been defined. Dopaminergic modulation from the A11 nucleus of the hypothalamus contributes to plasticity in a model of chronic pain called hyperalgesic priming. Here we tested the hypothesis that the key receptor subtype mediating this effect is the D5 receptor (D5R). We find that a spinally-directed lesion of dopaminergic neurons reverses hyperalgesic priming in both sexes and that a D1/D5 antagonist transiently inhibits neuropathic pain...
November 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29118889/successful-treatment-of-iatrogenic-external-iliac-artery-perforation-with-covered-stent-case-report-and-review-of-the-literature
#13
Muhammad Umer Awan, Bassam Omar, Ghazanfar Qureshi, Ghulam Mustafa Awan
Retroperitoneal hemorrhage from iliac artery injury is a potentially serious complication of vascular interventional procedures leading to hemorrhagic shock and death if not diagnosed early and treated promptly. We report a 70-year-old male admitted to our facility with non-ST-elevation myocardial infarction, whose heart catheterization revealed left anterior descending artery (LAD) with 80% proximal, 95% mid and 100% distal disease. The left circumflex and right coronary arteries were 100% occluded proximally and received collaterals from the LAD...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29116599/the-class-a-gpcr-dopamine-d2-receptor-forms-transient-dimers-stabilized-by-agonists-detection-by-single-molecule-tracking
#14
Rinshi S Kasai, Shuichi V Ito, Ryo M Awane, Takahiro K Fujiwara, Akihiro Kusumi
Whether class-A G-protein coupled receptors (GPCRs) exist and work as monomers or dimers has drawn extensive attention. A class-A GPCR dopamine D2 receptor (D2R) is involved in many physiological and pathological processes and diseases, indicating its critical role in proper functioning of neuronal circuits. In particular, D2R homodimers might play key roles in schizophrenia development and amphetamine-induced psychosis. Here, using single-molecule imaging, we directly tracked single D2R molecules in the plasma membrane at a physiological temperature of 37 °C, and unequivocally determined that D2R forms transient dimers with a lifetime of 68 ms in its resting state...
November 7, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29109253/a-transient-dopamine-signal-encodes-subjective-value-and-causally-influences-demand-in-an-economic-context
#15
Scott A Schelp, Katherine J Pultorak, Dylan R Rakowski, Devan M Gomez, Gregory Krzystyniak, Raibatak Das, Erik B Oleson
The mesolimbic dopamine system is strongly implicated in motivational processes. Currently accepted theories suggest that transient mesolimbic dopamine release events energize reward seeking and encode reward value. During the pursuit of reward, critical associations are formed between the reward and cues that predict its availability. Conditioned by these experiences, dopamine neurons begin to fire upon the earliest presentation of a cue, and again at the receipt of reward. The resulting dopamine concentration scales proportionally to the value of the reward...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29103933/optogenetic-blockade-of-dopamine-transients-prevents-learning-induced-by-changes-in-reward-features
#16
Chun Yun Chang, Matthew Gardner, Maria Gonzalez Di Tillio, Geoffrey Schoenbaum
Prediction errors are critical for associative learning [1, 2]. Transient changes in dopamine neuron activity correlate with positive and negative reward prediction errors and can mimic their effects [3-15]. However, although causal studies show that dopamine transients of 1-2 s are sufficient to drive learning about reward, these studies do not address whether they are necessary (but see [11]). Further, the precise nature of this signal is not yet fully established. Although it has been equated with the cached-value error signal proposed to support model-free reinforcement learning, cached-value errors are typically confounded with errors in the prediction of reward features [16]...
November 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29090092/current-understanding-of-the-molecular-mechanisms-in-parkinson-s-disease-targets-for-potential-treatments
#17
REVIEW
Panchanan Maiti, Jayeeta Manna, Gary L Dunbar
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson's disease (PD). In addition, half of the PD patients also exhibit frontostriatal-mediated executive dysfunction, including deficits in attention, short-term working memory, speed of mental processing, and impulsivity. The most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of patients...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29082315/n-arachidonoyl-dopamine-a-novel-endocannabinoid-and-endovanilloid-with-widespread-physiological-and-pharmacological-activities
#18
REVIEW
Urszula Grabiec, Faramarz Dehghani
N-arachidonoyl dopamine (NADA) is a member of the family of endocannabinoids to which several other N-acyldopamines belong as well. Their activity is mediated through various targets that include cannabinoid receptors or transient receptor potential vanilloid (TRPV)1. Synthesis and degradation of NADA are not yet fully understood. Nonetheless, there is evidence that NADA plays an important role in nociception and inflammation in the central and peripheral nervous system. The TRPV1 receptor, for which NADA is a potent agonist, was shown to be an endogenous transducer of noxious heat...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29068793/use-of-fast-scan-cyclic-voltammetry-to-assess-phasic-dopamine-release-in-rat-models-of-early-postpartum-maternal-behavior-and-neglect
#19
Tatiana A Shnitko, Kyla D Mace, Kaitlin M Sullivan, W Kyle Martin, Elizabeth H Andersen, Sarah K Williams Avram, Josephine M Johns, Donita L Robinson
Maternal behavior (MB) is a complex response to infant cues, orchestrated by postpartum neurophysiology. Although mesolimbic dopamine contributes toward MB, little is known about real-time dopamine fluctuations during the postpartum period. Thus, we used fast-scan cyclic voltammetry to measure individual dopamine transients in the nucleus accumbens of early postpartum rats and compared them with dopamine transients in virgins and in postpartum females exposed to cocaine during pregnancy, which is known to disrupt MB...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29054857/diazepam-concurrently-increases-the-frequency-and-decreases-the-amplitude-of-dopamine-transient-release-events-in-the-nucleus-accumbens
#20
Scott A Schelp, Zachary D Brodnik, Dylan R Rakowski, Katherine J Pultorak, Asha T Sambells, Rodrigo A Espana, Erik B Oleson
Benzodiazepines are commonly prescribed anxiolytics that pose abuse liability in susceptible individuals. While it is well established that all drugs of abuse increase brain dopamine levels and benzodiazepines are allosteric modulators of the GABAAR, it remains unclear how they alter dopamine release. Using in vivo fast-scan cyclic voltammetry, we measured diazepam (trade name valium) induced changes in the frequency and amplitude of transient dopamine release events. We found that diazepam concurrently increase the frequency and decreases the amplitude of transient dopamine release events in the awake and freely-moving rat...
October 20, 2017: Journal of Pharmacology and Experimental Therapeutics
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