keyword
https://read.qxmd.com/read/38178152/impaired-cerebral-microvascular-endothelial-cells-integrity-due-to-elevated-dopamine-in-myasthenic-model
#21
JOURNAL ARTICLE
Yue Hao, Yinchun Su, Yifan He, Wenyuan Zhang, Yang Liu, Yu Guo, Xingfan Chen, Chunhan Liu, Siyu Han, Buyi Wang, Yushuang Liu, Wei Zhao, Lili Mu, Jinghua Wang, Haisheng Peng, Junwei Han, Qingfei Kong
Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, depression, and other neurological symptoms, suggesting the complex nature of the neurological manifestations. With the aim of explaining the symptoms related to the central nervous system, we utilized a rat model to investigate the impact of dopamine signaling in the central nervous and peripheral circulation...
January 4, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38137174/treadmill-exercise-reverses-the-adverse-effects-of-intermittent-fasting-on-behavior-and-cortical-spreading-depression-in-young-rats
#22
JOURNAL ARTICLE
Amanda Ferraz Braz, Maria Luísa Figueira de Oliveira, Dominique Hellen Silva da Costa, Francisco Leonardo Torres-Leal, Rubem Carlos Araújo Guedes
Intermittent fasting (IF) and physical exercise (PE) have beneficial psychological and physiological effects, improving memory and anxiety-like behavior. However, the impact of this combination on brain electrophysiological patterns is unknown. We aimed to evaluate the behavior and parameters of a brain excitability-related phenomenon named cortical spreading depression (CSD) in young rats (31-87 days of life) submitted to IF and treadmill PE for eight weeks. Sixty-four male and female Wistar rats aged 24 days were randomized into control, IF, PE, and IF+PE groups...
December 17, 2023: Brain Sciences
https://read.qxmd.com/read/38135278/chronic-stress-induced-elevation-of-melanin-concentrating-hormone-in-the-locus-coeruleus-inhibits-norepinephrine-production-and-associated-with-depression-like-behaviors-in-rats
#23
JOURNAL ARTICLE
Nurhumar Kurban, Yu Qin, Hui-Ling Zhao, Xiao Hu, Xi Chen, Yi-Yi Zhao, Yu-Shuo Peng, Hong-Bo Wang, Su-Ying Cui, Yong-He Zhang
BACKGROUND: Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that projects throughout the central nervous system, including the noradrenergic locus coeruleus (LC). Our previous study suggested that MCH/MCH receptor 1 (MCHR1) in the LC may be involved in the regulation of depression. The present study investigated whether the role of MCH/MCHR1 in the LC in depression-like behaviors is associated with the regulation of norepinephrine. METHOD: Chronic unpredictable stress (CUS) and an acute intra-LC microinjection of MCH induced depression-like behaviors in rats...
December 22, 2023: International Journal of Neuropsychopharmacology
https://read.qxmd.com/read/38128891/assessment-of-the-anxiolytic-antidepressant-and-antioxidant-potential-of-parquetina-nigrescens-afzel-bullock-in-wistar-rats
#24
JOURNAL ARTICLE
Ayokunmi Adebukola Akinduko, Sule Ola Salawu, Afolabi Clement Akinmoladun, Afolabi Akintunde Akindahunsi, Osarenkhoe Omorefosa Osemwegie
ETHNOPHARMACOLOGICAL RELEVANCE: The recent growing concerns about the multisystemic nature of mental health conditions in the global population are facilitating a new paradigm involving alternative natural, nutritional, and complementary therapies. Herbal remedies despite accounts in literature of their ethnobotanical as alternative remedies for diverse ailments, remain underexplored for psychiatric disorders like anxiety, depression, and insomnia. AIM OF THE STUDY: Hence, the anxiolytic, antidepressant, and antioxidant properties of a hydro-ethanolic leaf extract of Parquetina nigrescens (PN) in male Wistar rats were investigated...
December 19, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38113957/di-2-ethylhexyl-phthalate-alters-neurobehavioral-responses-and-oxidative-status-architecture-and-gfap-and-bdnf-signaling-in-juvenile-rat-s-brain-protective-role-of-coenzyme10
#25
JOURNAL ARTICLE
Naglaa Z H Eleiwa, Alaa S F Elsayed, Enas N Said, Mohamed M M Metwally, Yasmina M Abd-Elhakim
Di-(2-ethylhexyl) phthalate (DEHP), a phthalate plasticizer, is widely spread in the environment, presenting hazards to human health and food safety. Hence, this study examined the probable preventive role of coenzyme10 (CQ10) (10 mg/kg.b.wt) against DEHP (500 mg/kg.wt) - induced neurotoxic and neurobehavioral impacts in juvenile (34 ± 1.01g and 3 weeks old) male Sprague Dawley rats in 35-days oral dosing trial. The results indicated that CQ10 significantly protected against DEHP-induced memory impairment, anxiety, depression, spatial learning disorders, and repetitive/stereotypic-like behavior...
December 17, 2023: Food and Chemical Toxicology
https://read.qxmd.com/read/38103709/trek-1-inhibition-promotes-synaptic-plasticity-in-the-prelimbic-cortex
#26
JOURNAL ARTICLE
José Francis-Oliveira, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Emily Cruvinel, Estevão Carlos Lima, Fernando da Silva Borges, Thais Zampieri, Fernanda Pereira Rebello, Henning Ulrich, Roberto De Pasquale
Synaptic plasticity is one of the putative mechanisms involved in the maturation of the prefrontal cortex (PFC) during postnatal development. Early life stress (ELS) affects the shaping of cortical circuitries through impairment of synaptic plasticity supporting the onset of mood disorders. Growing evidence suggests that dysfunctional postnatal maturation of the prelimbic division (PL) of the PFC might be related to the emergence of depression. The potassium channel TREK-1 has attracted particular interest among many factors that modulate plasticity, concerning synaptic modifications that could underlie mood disorders...
December 14, 2023: Experimental Neurology
https://read.qxmd.com/read/38081330/reducing-sugar-intake-through-chronic-swimming-training-exploring-palatability-changes-and-central-vasopressin-mechanisms
#27
JOURNAL ARTICLE
Marcone Rodrigues da Silva E Santos, Milede Hanner Paes, Renata Cristina Queiroz Silva Bento, Leonardo Máximo Cardoso, Lisandra Brandino de Oliveira
Excessive sugar intake has been associated with the onset of several non-communicable chronic diseases seen in humans. Physical activity could affect sweet taste perception which may affect sugar intake. Therefore, it was investigated the chronic effects of swimming training on sucrose intake/preference, reactivity to sucrose taste, self-care in neurobehavioral stress, and the possible involvement of the vasopressin type V1 receptor in sucrose solution intake. Male Wistar rats, of from different cohorts were used, subjected to a sedentary lifestyle (SED) or swimming training (TR - 1 h/day, 5×/week, for 8 weeks, with no added load)...
December 9, 2023: Pharmacology, Biochemistry, and Behavior
https://read.qxmd.com/read/38064347/the-differential-sensitivity-of-the-hypothalamic-hypophysial-ovarian-axis-to-5-hydroxytryptophan-alters-the-secretion-of-estradiol
#28
JOURNAL ARTICLE
Juana Monroy, Omar D Cortés, Roberto Domínguez, María Eugenia Mendoza-Garrido, Eloir Gallegos, Mario Cárdenas, Andrés Aragón, María E Ayala
Serotonin [5-hydroxytryptamine (5-HT)] modulates ovarian function. The precursor of 5-HT, 5-hydroxytryptophan (5-HTP), has been used to treat depression. However, the effects of 5-HTP on ovarian and reproductive physiology remain unknown. In this research, we analysed the impact of 5-HTP on the monoaminergic system and its interactions with the reproductive axis and ovarian estradiol secretion when administered by distinct routes. Female rats 30 days of age were injected with 5-HTP i.p. (100 mg/kg), into the ovarian bursa (1...
December 8, 2023: Experimental Physiology
https://read.qxmd.com/read/38059293/exercise-induced-neuroplasticity-in-autonomic-nuclei-restores-the-cardiac-vagal-tone-and-baroreflex-dysfunction-in-aged-hypertensive-rats
#29
JOURNAL ARTICLE
Lais Oliveira Dellacqua, Paula Magalhães Gomes, Julia Santos Batista, Lisete Compagno Michelini, Vagner Roberto Antunes
Aging is accompanied by considerable deterioration of homeostatic systems, such as autonomic imbalance characterized by heightened sympathetic activity, lower parasympathetic tone, and depressed heart rate (HR) variability, which are aggravated by hypertension. Here, we hypothesized that these age-related deficits in aged hypertensive rats can be ameliorated by exercise training, with benefits to the cardiovascular system. Therefore, male 22 month-old Spontaneously Hypertensive Rats (SHR) and age-matched Wistar Kyoto (WKY) submitted to moderate-intensity exercise training (T) or kept sedentary (S) for 8 weeks were evaluated for hemodynamic/autonomic parameters, baroreflex sensitivity, cardiac sympathetic/parasympathetic tone and analysis of dopamine β-hydroxylase (DBH) and oxytocin (OT) pathways of autonomic brain nuclei...
December 7, 2023: Journal of Applied Physiology
https://read.qxmd.com/read/38026921/ketamine-promptly-normalizes-excess-norepinephrine-and-enhances-dopamine-neuronal-activity-in-wistar-kyoto-rats
#30
JOURNAL ARTICLE
Stephen Daniels, Mostafa El Mansari, Rami Hamoudeh, Pierre Blier
Ketamine acts primarily by blocking the N-methyl-D-aspartate (NMDA) receptor at the phencyclidine site. The rapid antidepressant properties of ketamine were demonstrated in the clinic and several behavioral models of depression in rodents. We hypothesized that the normalization of abnormal activity of monoamine neurons in Wistar Kyoto (WKY) rats contributes to the rapid antidepressant effects of ketamine. A single administration of ketamine (10 mg/kg, i. p) or saline was administered to anesthetized WKY rats before in vivo electrophysiological recordings of dorsal raphe nucleus (DRN) serotonin (5-HT), locus coeruleus (LC) norepinephrine (NE) and ventral tegmental area (VTA) dopamine (DA) neuronal activity...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38025387/quantitative-and-qualitative-sex-difference-in-habenula-induced-inhibition-of-midbrain-dopamine-neurons-in-the-rat
#31
JOURNAL ARTICLE
Dana Bell, Vaughn J Waldron, P Leon Brown
INTRODUCTION: Clinically relevant sex differences have been noted in a number of affective, behavioral, cognitive, and neurological health disorders. Midbrain dopamine neurons are implicated in several of these same disorders and consequently are under investigation for their potential role in the manifestation of these sex differences. The lateral habenula exerts significant inhibitory control over dopamine neuronal firing, yet little is known about sex differences in this particular neurocircuit...
2023: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/38022903/evaluation-of-glycogen-synthase-kinase-pathway-for-assessing-the-antidepressant-like-effect-of-glucosamine-as-a-radioprotector-in-rats-behavioral-and-biochemical-studies
#32
JOURNAL ARTICLE
Mai H Mekkawy, Heba M Karam, Marwa A Mohamed, Dina M Lotfy
Radiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate oxidative stress biochemical parameters and glycogen synthase kinase pathway in addition to the biogenic amines...
2023: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/38017639/regulation-of-ethanol-mediated-dopamine-elevation-by-glycine-receptors-located-on-cholinergic-interneurons-in-the-nucleus-accumbens
#33
JOURNAL ARTICLE
Anna Loftén, Louise Adermark, Mia Ericson, Bo Söderpalm
Alcohol use disorder is one of the major psychiatric disorders worldwide, and there are many factors and effects contributing to the disorder, for example, the experience of ethanol reward. The rewarding and reinforcing properties of ethanol have been linked to activation of the mesolimbic dopamine system, an effect that appears to involve glycine receptors (GlyRs) in the nucleus accumbens. On which neuronal subtypes these receptors are located is, however, not known. The aim of this study was to explore the role of GlyRs on cholinergic interneurons (CIN) in sustaining extracellular dopamine levels and in ethanol-induced dopamine release...
December 2023: Addiction Biology
https://read.qxmd.com/read/38002521/cashew-anacardium-occidentale-extract-possible-effects-on-hypothalamic-pituitary-adrenal-hpa-axis-in-modulating-chronic-stress
#34
JOURNAL ARTICLE
Guedang Nyayi Simon Désiré, Foyet Harquin Simplice, Camdi Woumitna Guillaume, Fatima Zahra Kamal, Bouvourné Parfait, Tchinda Defo Serge Hermann, Ngatanko Abaissou Hervé Hervé, Keugong Wado Eglantine, Damo Kamda Jorelle Linda, Rebe Nhouma Roland, Kamleu Nkwingwa Balbine, Kenko Djoumessi Lea Blondelle, Alin Ciobica, Laura Romila
Depression presents a significant global health burden, necessitating the search for effective and safe treatments. This investigation aims to assess the antidepressant effect of the hydroethanolic extract of Anacardium occidentale (AO) on depression-related behaviors in rats. The depression model involved 42 days of unpredictable chronic mild stress (UCMS) exposure and was assessed using the sucrose preference and the forced swimming (FST) test. Additionally, memory-related aspects were examined using the tests Y-maze and Morris water maze (MWM), following 21 days of treatment with varying doses of the AO extract (150, 300, and 450 mg/kg) and Imipramine (20 mg/kg), commencing on day 21...
November 7, 2023: Brain Sciences
https://read.qxmd.com/read/38001881/alterations-in-serotonin-neurotransmission-in-hyperdopaminergic-rats-lacking-the-dopamine-transporter
#35
JOURNAL ARTICLE
Dmitrii S Traktirov, Ilya R Nazarov, Valeria S Artemova, Raul R Gainetdinov, Nina S Pestereva, Marina N Karpenko
Biogenic amines dopamine (DA) and serotonin (5-HT) are among the most significant monoaminergic neurotransmitters in the central nervous system (CNS). Separately, the physiological roles of DA and 5-HT have been studied in detail, and progress has been made in understanding their roles in normal and various pathological conditions (Parkinson's disease, schizophrenia, addiction, depression, etc.). In this article we showed that knockout of the gene encoding DAT leads not only to a profound dysregulation of dopamine neurotransmission in the striatum but also in the midbrain, prefrontal cortex, hippocampus, medulla oblongata and spinal cord...
October 24, 2023: Biomedicines
https://read.qxmd.com/read/37950769/immunoregulatory-role-of-hesperidin-against-ovalbumin-ova-induced-bronchial-asthma-and-depression-in-rats
#36
JOURNAL ARTICLE
Abeer Salama, Mona S O Gouida, Noha N Yassen, Ahmed A Sedik
Links between bronchial asthma and depression have recently become a great subject of interest. The present study was carried out to assess the protective role of hesperidin against ovalbumin (OVA)-induced bronchial asthma that is associated with depression in rats, for this purpose, four groups. Rats were sensitized with intraperitoneal administration of 200 μg OVA/10 mg aluminum hydroxide (Al (OH) 3 for 3 consecutive days then at day 11 followed by intranasal challenge with OVA (1.5 mg/kg) at days 19, 20, and 21...
November 11, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37942525/wistar-kyoto-rats-exhibit-decreased-serotonin-neuronal-firing-and-increased-norepinephrine-burst-activity-but-dampened-hippocampal-%C3%AE-2-adrenoceptor-sensitivity
#37
JOURNAL ARTICLE
Mostafa El Mansari, Rami Hamoudeh, Stephen Daniels, Pierre Blier
BACKGROUND: Wistar Kyoto (WKY) rats manifest abnormalities in the function of monoamine receptors and transporters, as well as levels of these neurotransmitters in the brain. The present study assessed alterations in the firing activity of serotonin (5-hydroxytryptamine [5-HT]), norepinephrine (NE), and dopamine (DA) neurons, as well as the activity of 5-HT and NE receptors and transporters in the hippocampus. METHODS: In vivo electrophysiological recordings were conducted in male WKY and Wistar rats...
November 9, 2023: Journal of Psychopharmacology
https://read.qxmd.com/read/37933822/the-development-and-full-validation-of-a-novel-liquid-chromatography-electrochemical-detection-method-for-simultaneous-determination-of-nine-catecholamines-in-rat-brain
#38
JOURNAL ARTICLE
Saniye Özcan, Aysun Geven, Murat Kozanlı, Nafiz Öncü Can
OBJECTIVES: Chemical neurotransmission, managed by neurotransmitters, has a crucial role in brain processes such as fear, memory, learning, and pain, or neuropathology such as schizophrenia, epilepsy, anxiety/depression, and Parkinson's disease. The measurement of these compounds is used to elucidate the disease mechanisms and evaluate the outcomes of therapeutic interventions. However, this can be quite difficult because of various matrix effects and the problems of chromatographic separation of analysts...
November 7, 2023: Turkish journal of pharmaceutical sciences
https://read.qxmd.com/read/37851944/tailoring-efficient-fluorogenic-tactic-for-ultrasensitive-detection-of-dopamine-in-urine-and-rat-brain-through-real-time-and-in-situ-formation-of-high-performance-fluorophore
#39
JOURNAL ARTICLE
Zi Yi Xu, Xiao Dong He, Hong Qun Luo, Li Qun Xu, Nian Bing Li
Owing to the predominance of dopamine (DA) in controlling mental health, planning an innovative method for DA detection with simplicity and high efficacy is conducive to the assessment of neurological disorders. Herein, an efficient fluorogenic tactic has been elaborated for ultrasensitive detection of DA with remarkably enhanced turn-on response. Utilizing a twisted intramolecular charge-transfer (TICT)-suppressing strategy, a highly emissive azocine derivative 11-hydroxy-2,3,6,7,11,12,13,14-octahydro-1 H ,5 H ,10 H -11,14a-methanoazocino[5',4':4,5]furo[2,3- f ]pyrido[3,2,1- ij ]quinolin-10-one ( J-Aza ) is generated via a one-step reaction between DA and 8-hydroxyjulolidine...
October 18, 2023: Analytical Chemistry
https://read.qxmd.com/read/37840624/inhibition-of-sk-channels-in-vta-affects-dopaminergic-neurons-to-improve-the-depression-like-behaviors-of-post-stroke-depression-rats
#40
JOURNAL ARTICLE
Anqi Wang, Yujia Zhou, Huangying Chen, Jiawei Jin, Yingqi Mao, Shuiliang Tao, Tao Qiu
PURPOSE: This study aimed to investigate the effect of small-conductance calcium-activated potassium channels (SK channels) on the dopaminergic (DA) neuron pathways in the ventral tegmental area (VTA) during the pathogenesis of post-stroke depression (PSD) and explore the improvement of PSD by inhibiting the SK channels. PATIENTS AND METHODS: Four groups of Sprague-Dawley rats were randomly divided: Control, PSD, SK channel inhibitor (apamin) and SK channel activator (CyPPA) groups...
2023: Neuropsychiatric Disease and Treatment
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