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https://www.readbyqxmd.com/read/27913254/quetiapine-treatment-reverses-depressive-like-behavior-and-reduces-dna-methyltransferase-activity-induced-by-maternal-deprivation
#1
Zuleide M Ignácio, Gislaine Z Réus, Helena M Abelaira, Amanda L Maciel, Airam B de Moura, Danyela Matos, Júlia P Demo, Júlia B I da Silva, Fernanda F Gava, Samira S Valvassori, André F Carvalho, João Quevedo
Stress in early life has been appointed as an important phenomenon in the onset of depression and poor response to treatment with classical antidepressants. Furthermore, childhood trauma triggers epigenetic changes, which are associated with the pathophysiology of major depressive disorder (MDD). Treatment with atypical antipsychotics such as quetiapine, exerts therapeutic effect for MDD patients and induces epigenetic changes. This study aimed to analyze the effect of chronic treatment with quetiapine (20mg/kg) on depressive-like behavior of rats submitted to maternal deprivation (MD), as well as the activity of histone acetylation by the enzymes histone acetyl transferases (HAT) and deacetylases (HDAC) and DNA methylation, through DNA methyltransferase enzyme (DNMT) in the prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus...
November 29, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27880890/potential-antidepressant-and-resilience-mechanism-revealed-by-metabolomic-study-on-peripheral-blood-mononuclear-cells-of-stress-resilient-rats
#2
Juan Li, Shu-Xiao Zhang, Wei Wang, Ke Cheng, Hua Guo, Cheng-Long Rao, De-Yu Yang, Yong He, De-Zhi Zou, Yu Han, Li-Bo Zhao, Peng-Fei Li, Peng Xie
Resilience is an active coping response to stress, which plays a very important role in major depressive disorder study. The molecular mechanisms underlying such resilience are poorly understood. Peripheral blood mononuclear cells (PBMCs) were promising objects in unveiling the underlying pathogenesis of resilience. Hereby we carried out successive study on PBMCs metabolomics in resilient rats of chronic unpredictable mild stress (CUMS) model. A gas chromatography-mass spectrometry (GC-MS) metabolomic approach coupled with principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) was used to detect differential metabolites in PBMCs of resilient rats...
November 21, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27873013/neonatal-l-glutamine-modulates-anxiety-like-behavior-cortical-spreading-depression-and-microglial-immunoreactivity-analysis-in-developing-rats-suckled-on-normal-size-and-large-size-litters
#3
Denise Sandrelly Cavalcanti de Lima, Elian da Silva Francisco, Cássia Borges Lima, Rubem Carlos Araújo Guedes
In mammals, L-glutamine (Gln) can alter the glutamate-Gln cycle and consequently brain excitability. Here, we investigated in developing rats the effect of treatment with different doses of Gln on anxiety-like behavior, cortical spreading depression (CSD), and microglial activation expressed as Iba1-immunoreactivity. Wistar rats were suckled in litters with 9 and 15 pups (groups L 9 and L 15; respectively, normal size- and large size litters). From postnatal days (P) 7-27, the animals received Gln per gavage (250, 500 or 750 mg/kg/day), or vehicle (water), or no treatment (naive)...
November 21, 2016: Amino Acids
https://www.readbyqxmd.com/read/27802175/neurotransmitter-alteration-in-a-testosterone-propionate-induced-polycystic-ovarian-syndrome-rat-model
#4
Nirja K Chaudhari, Laxmipriya P Nampoothiri
BACKGROUND: Polycystic ovarian syndrome (PCOS), one of the leading causes of infertility seen in women, is characterized by anovulation and hyperandrogenism, resulting in ovarian dysfunction. In addition, associations of several metabolic complications like insulin resistance, obesity, dyslipidemia and psychological co-morbidities are well known in PCOS. One of the major factors influencing mood and the emotional state of mind is neurotransmitters. Also, these neurotransmitters are very crucial for GnRH release...
October 29, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27755991/risperidone-and-escitalopram-co-administration-a-potential-treatment-of-schizophrenia-symptoms-with-less-side-effects
#5
Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Alexandra Jurczak, Anna Górska, Zofia Rogóż, Krystyna Gołembiowska
BACKGROUND: Schizophrenia is a psychiatric disorder characterized by positive and negative symptoms often accompanied by depression and cognitive deficits. Positive symptoms, like delusions and hallucinations are caused by an excess of dopamine (DA) signaling and are treated with the second generation antipsychotic drugs. Negative symptoms of schizophrenia are represented by social withdrawal, apathy and blunted emotional response. It was demonstrated that co-administration of risperidone and selective serotonin reuptake inhibitors alleviated depressive symptoms and cognitive dysfunction in animal models of schizophrenia...
September 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27721791/dopamine-d1-d5-but-not-d2-d3-receptor-dependency-of-synaptic-plasticity-at-hippocampal-mossy-fiber-synapses-that-is-enabled-by-patterned-afferent-stimulation-or-spatial-learning
#6
Hardy Hagena, Denise Manahan-Vaughan
Although the mossy fiber (MF) synapses of the hippocampal CA3 region display quite distinct properties in terms of the molecular mechanisms that underlie synaptic plasticity, they nonetheless exhibit persistent (>24 h) synaptic plasticity that is akin to that observed at the Schaffer collateral (SCH)-CA1 and perforant path (PP)-dentate gyrus (DG) synapses of freely behaving rats. In addition, they also respond to novel spatial learning with very enduring forms of long-term potentiation (LTP) and long-term depression (LTD)...
2016: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/27623554/antidepressant-like-effects-and-cognitive-enhancement-of-the-total-phenols-extract-of-hemerocallis-citrina-baroni-in-chronic-unpredictable-mild-stress-rats-and-its-related-mechanism
#7
Pan Xu, Ke Zhu Wang, Cong Lu, Li Ming Dong, Jun Le Zhai, Yong Hong Liao, Silafu Aibai, Xin Min Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Depression induce distressed emotional state and cognitve deficits simultaneously, which both should be improved in the treatment. Hemerocallis citrina Baroni (HC) is a traditional herbal medicine in Eastern-Asia areas and the total phenols extract of HC (HCPE) contains the main active ingredients. It has been reported that HC has the emotional improvement effect. But the cognitive effect of HC was seldom researched. AIM OF THE STUDY: We designed to evaluate the antidepressant and cognitive improvement effect of HCPE using a chronic unpredictable mild stress (CUMS) model, and the potential mechanisms were explored by investigating the corticosterone (CORT), monoamine neurotansmitters, brain-derived neurotropic factor (BDNF) and oxidative stress...
September 10, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27590136/ketamine-exhibits-different-neuroanatomical-profile-after-mammalian-target-of-rapamycin-inhibition-in-the-prefrontal-cortex-the-role-of-inflammation-and-oxidative-stress
#8
Helena M Abelaira, Gislaine Z Réus, Zuleide M Ignácio, Maria Augusta B Dos Santos, Airam B de Moura, Danyela Matos, Júlia P Demo, Júlia B I da Silva, Lucineia G Danielski, Fabricia Petronilho, André F Carvalho, João Quevedo
Studies indicated that mammalian target of rapamycin (mTOR), oxidative stress, and inflammation are involved in the pathophysiology of major depressive disorder (MDD). Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been identified as a novel MDD therapy; however, the antidepressant mechanism is not fully understood. In addition, the effects of ketamine after mTOR inhibition have not been fully investigated. In the present study, we examined the behavioral and biochemical effects of ketamine in the prefrontal cortex (PFC), hippocampus, amygdala, and nucleus accumbens after inhibition of mTOR signaling in the PFC...
September 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27544303/anandamide-reverses-depressive-like-behavior-neurochemical-abnormalities-and-oxidative-stress-parameters-in-streptozotocin-diabetic-rats-role-of-cb1-receptors
#9
Helen de Morais, Camila P de Souza, Luisa M da Silva, Daniele M Ferreira, Cristiane Hatsuko Baggio, Ana Carolina Vanvossen, Milene Cristina de Carvalho, José Eduardo da Silva-Santos, Leandro José Bertoglio, Joice M Cunha, Janaina M Zanoveli
The pathophysiology associated with increased prevalence of depression in diabetics is not completely understood, although studies have pointed the endocannabinoid system as a possible target. Then, we aimed to investigate the role of this system in the pathophysiology of depression associated with diabetes. For this, diabetic (DBT) male Wistar rats were intraperitoneally treated with cannabinoid CB1 (AM251, 1mg/kg) or CB2 (AM630, 1mg/kg) receptor antagonists followed by anandamide (AEA, 0.005mg/kg) and then submitted to the forced swimming test (FST)...
October 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27524835/the-dopamine-d1-receptor-agonist-skf81297-has-dose-related-effects-on-locomotor-activity-but-is-without-effect-in-a-cer-trace-conditioning-procedure-conducted-with-two-versus-four-trials
#10
M A Pezze, H J Marshall, H J Cassaday
In an appetitively motivated procedure, we have previously reported that systemic treatment with the dopamine (DA) D1 receptor agonist SKF81297 (0.4 and 0.8 mg/kg) depressed acquisition at a 2 s inter-stimulus-interval (ISI), suitable to detect trace conditioning impairment. However since DA is involved in reinforcement processes, the generality of effects across appetitively- and aversively-motivated trace conditioning procedures cannot be assumed. The present study tested the effects of SKF81297 (0.4 and 0...
August 2016: Learning and Motivation
https://www.readbyqxmd.com/read/27424103/activation-and-blockade-of-prelimbic-5-ht6-receptors-produce-different-effects-on-depressive-like-behaviors-in-unilateral-6-hydroxydopamine-induced-parkinson-s-rats
#11
Yu-Ming Zhang, Li Zhang, Yong Wang, Yi-Na Sun, Yuan Guo, Cheng-Xue Du, Jin Zhang, Lu Yao, Shu-Qi Yu, Jian Liu
The role of prelimbic (PrL) 5-HT6 receptors in depression is poorly understood, particularly in Parkinson's disease-related depression. Here we reported that 6-hydroxydopamine lesions in rats decreased sucrose preference and increased immobility time as measured by the sucrose preference and forced swim tests when compared to sham-operated rats, indicating the induction of depressive-like behaviors. Intra-PrL injection of 5-HT6 receptor agonist WAY208466 induced depressive-like responses in sham-operated rats, and produced antidepressant-like effects in the lesioned rats...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27371920/metabonomic-identification-of-the-effects-of-the-zhimu-baihe-saponins-on-a-chronic-unpredictable-mild-stress-induced-rat-model-of-depression
#12
Hongli Du, Keqing Wang, Li Su, Hongxia Zhao, Songyan Gao, Qishan Lin, Xiaofang Ma, Baokang Zhu, Xin Dong, Ziyang Lou
The herbal pair Zhimu-Baihe (Zhimu: Anemarrhena asphodeloides; Baihe: Lilium brownii var. viridulum) is a traditional Chinese medicament used for the treatment of depression. However, the relevant mechanisms of action has not been clarified. This study investigated the anti-depressant activity of the total saponins from Zhimu and Baihe and the mechanisms underlying using a chronic unpredictable mild stress (CUMS)-induced rat model of depression. High performance liquid chromatography with electrochemical detection (HPLC-ECD) was applied to determine the levels of three monoamine neurotransmitters, 5-hydroxytryptamine (5-HT), noradrenaline (NE) and dopamine (DA), in the rat hippocampus...
September 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27369326/pain-relief-induces-dopamine-release-in-the-rat-nucleus-accumbens-during-the-early-but-not-late-phase-of-neuropathic-pain
#13
Takahiro Kato, Soichiro Ide, Masabumi Minami
Comorbidity of chronic pain and depression has long been recognized in the clinic, and preclinical studies have reported depression-like behaviors in animal models of chronic pain. These findings suggest a common neuronal basis for chronic pain and depression. The neuronal pathway from the ventral tegmental area to the nucleus accumbens (NAc) is critical in the mesolimbic dopamine (DA) reward circuit, and dysfunction of this pathway has been implicated in depression. Although time-dependent development of depression-related behaviors has been reported in chronic pain animals, time-dependent functional changes in this pathway remain to be examined...
August 26, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27233481/thyroid-hormone-disruption-and-cognitive-impairment-in-rats-exposed-to-pbde-during-postnatal-development
#14
Andressa S de-Miranda, Sergio N Kuriyama, Camille S da-Silva, Monicke S C do-Nascimento, Thiago E M Parente, Francisco J R Paumgartten
Polybrominated diphenyl ether flame-retardants (PBDEs) are thyroid-disrupting environmental chemicals. We investigated the effects of postnatal exposure to DE-71 (a mixture of tetra- and penta-brominated congeners), n-propylthiouracil (PTU) and thyroxine (T4) replacement on open-field (OF) and radial maze (RAM) tests. Wistar rats (5 males/5 females per litter, 32 litters) were treated orally (PND 5-22) with PTU (4mg/kg bw/d), DE-71 (30mg/kg bw/d), with and without co-administration of T4 (15μg/kg bw/d, sc)...
August 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27142317/loss-of-dopaminergic-neurons-occurs-in-the-ventral-tegmental-area-and-hypothalamus-of-rats-following-chronic-stress-possible-pathogenetic-loci-for-depression-involved-in-parkinson-s-disease
#15
Shuei Sugama, Yoshihiko Kakinuma
Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic (DA) neurons in the nigrostriatal and mesolimbic pathways including ventral tegmental area (VTA). Although several factors for the neuronal loss have been suggested, most of the PD cases are sporadic and idiopathic. In our previous study, we demonstrated the first evidence that solely chronic restraint stress (RS) induced the DA neuronal loss in the substantia nigra (SN). In this study, we further investigated whether chronic stress could affect other major DA systems, VTA and tuberoinfundibular system (TIDA), by using immunohistochemical and in situ hybridization techniques...
October 2016: Neuroscience Research
https://www.readbyqxmd.com/read/27003115/the-role-of-medial-prefrontal-corticosterone-and-dopamine-in-the-antidepressant-like-effect-of-exercise
#16
Chong Chen, Shin Nakagawa, Yuji Kitaichi, Yan An, Yuki Omiya, Ning Song, Minori Koga, Akiko Kato, Takeshi Inoue, Ichiro Kusumi
Despite the well-documented beneficial effect of exercise on stress coping and depression treatment, its underlying neurobiological mechanism remains unclear. This is further complicated by a 'side effect' of exercise: it increases basal glucocorticoid (CORT), the stress hormone, which has been shown to be a mediator linking stress to depressive disorders. Here we show that three weeks of voluntary wheel running reduced rats' immobility in the forced swim test (FST), an antidepressant-like effect. Monitoring extracellular fluids in the medial prefrontal cortex PFC (mPFC) using microdialysis we found that, wheel running was associated with higher baseline CORT, but lower FST-responsive CORT...
July 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/26901591/effects-of-gaboxadol-on-the-expression-of-cocaine-sensitization-in-rats
#17
Nora Siegal Silverman, Susanna Popp, Vincent Vialou, Konstantin Astafurov, Eric J Nestler, Diana Dow-Edwards
Behavioral sensitization to psychostimulants is associated with changes in dopamine (DA), glutamate, and GABA within the mesocorticolimbic and nigrostriatal DA systems. Because GABAA receptors are highly expressed within these systems, we examined the role of these receptors containing a δ subunit in cocaine behavioral sensitization. Experiment 1 examined the effects of Gaboxadol (GBX, also known as THIP [4,5,6,7-tetrahydro-isoxazolo[5,4-c]pyridin-3-ol]), a selective δ-GABAA receptor agonist, on the locomotor responses to acute cocaine...
April 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26899746/the-pharmacology-of-effort-related-choice-behavior-dopamine-depression-and-individual-differences
#18
REVIEW
John D Salamone, Merce Correa, Samantha Yohn, Laura Lopez Cruz, Noemi San Miguel, Luisa Alatorre
This review paper is focused upon the involvement of mesolimbic dopamine (DA) and related brain systems in effort-based processes. Interference with DA transmission affects instrumental behavior in a manner that interacts with the response requirements of the task, such that rats with impaired DA transmission show a heightened sensitivity to ratio requirements. Impaired DA transmission also affects effort-related choice behavior, which is assessed by tasks that offer a choice between a preferred reinforcer that has a high work requirement vs...
June 2016: Behavioural Processes
https://www.readbyqxmd.com/read/26899441/anti-depressant-effects-of-gastrodia-elata-blume-and-its-compounds-gastrodin-and-4-hydroxybenzyl-alcohol-via-the-monoaminergic-system-and-neuronal-cytoskeletal-remodeling
#19
Wei-Cheng Chen, Yi-Syuan Lai, Shih-Hang Lin, Kuan-Hung Lu, Yu-En Lin, Suraphan Panyod, Chi-Tang Ho, Lee-Yan Sheen
ETHNOPHARMACOLOGY RELEVANCE: Gastrodia elata Blume is a highly valuable traditional Chinese medicine used in the treatment of depression. However, compounds with antidepressant effects in water extracts of G. elata Bl. (WGE) have not been identified. The aims of this study were to determine the major antidepressant compound in WGE and to evaluate the antidepressant effects of WGE and its active compounds which involved the monoaminergic system and neuronal cytoskeletal remodeling. MATERIALS AND METHODS: Gastrodin (GAS) and 4-hydroxybenzyl alcohol (HBA) in WGE, were analyzed with high-performance liquid chromatography (HPLC)-ultraviolet detection...
April 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26876447/effects-of-botulinum-toxin-type-a-facial-injection-on-monoamines-and-their-metabolites-in-sensory-limbic-and-motor-brain-regions-in-rats
#20
S Ibragić, I Matak, A Dračić, A Smajlović, M Muminović, F Proft, E Sofić, Z Lacković, P Riederer
Despite its toxicity, botulinum neurotoxin type A (BTX-A) is a valuable therapeutic agent for several motor, autonomic and pain disorders. Numerous studies have described its peripheral as well as central effects. Using reversed-phase High Performance Liquid Chromatography with Electrochemical Detection (HPLC-ED) and gradient elution, we quantified the concentrations of dopamine (DA), noradrenaline (NA), serotonin (5-HT) and their metabolites in 10 brain regions, ipsilateral and contralateral from the site of unilateral BTX-A administration (5 U/kg) into the rat whisker pad...
March 23, 2016: Neuroscience Letters
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