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Rat DA depression

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https://www.readbyqxmd.com/read/29218948/-preliminary-screening-of-biomarkers-for-curcumin-s-antidepressant-effect-based-on-metabonomics-method
#1
Zhi-Jie Ma, Wei Zhang, Jie-Ming Dong, Xiao-Hong Yu, Xiao-Mei Zhao, Shi-Biao Pu
To screen potential biomarkers of curcumin related to treating depression rats by using metabolomics means, so as to explore the antidepressant action mechanism of curcumin. The healthy male SD rats were randomly divided into four groups. Chronic unpredictable mild stress (CUMS) stimulation was conducted for modeling for 2 weeks, and then curcumin (200 mg•kg⁻¹) or venlafaxine (40 mg•kg⁻¹) was given by gavage administration. The blank group and model group rats were given with the same volume of 1% CMCNa normal saline, once per day for two weeks...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29188780/dizocilpine-induced-psychosis-like-behavior-in-rats-a-possible-animal-model-with-full-spectrum-of-schizophrenia
#2
Sidrah Shahzad, Saara Ahmad, Syeda Madiha, Saima Khaliq, Laraib Liaquat, Sadia Sadir, Sahar Rafiq, Saiqa Tabassum, Zehra Batool, Saida Haider
Schizophrenia (SZ) is categorized as neuropsychiatric disorder with reduced lifespan and significant impairments in social and vocational functioning. One of the best proposed pharmacological animal models is dizocilpine, as it can mimic the full spectrum of schizophrenic disorder including positive and negative symptoms along with cognitive deficits. Dizocilpine is N-methyl-D-aspartate (NMDA) receptor antagonist known to induce hyper-locomotion and stereotyped behavior in rodents. Present study was designed to develop an animal model of SZ via intraperitoneal administration of dizocilpine in rats (100-150g) at a dose of 0...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29169416/-decursin-reduces-reactive-oxygen-species-and-inhibits-cisplatin-induced-apoptosis-in-rat-renal-tubular-epithelial-cells
#3
Cuiqiong Li, Jianchun Li, Junming Fan, Lifeng Meng, Ling Cao
Objective To study the mechanism underlying the inhibitory effect of decursin on the apoptosis of rat renal tubular epithelial cells NRK-52E induced by cisplatin. Methods First, CCK-8 assay was used to detect the effects of 0, 10, 20, 40, 80, 100, 150, 200 μmol/L decursin and 0, 5, 10, 20, 30, 40, 50 μg/mL cispatin treatment for 24 hours on cell proliferation in NRK-52E cells via determining the half inhibitory concentration (IC50). Then, NRK-52E cells were stimulated with 20 μg/mL cisplatin combined with 10, 50, 100 μmol/L decursin, and cell activity was detected by CCK-8 assay...
October 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29153928/enhancing-excitability-of-dopamine-neurons-promotes-motivational-behaviour-through-increased-action-initiation
#4
Linde Boekhoudt, Ellen C Wijbrans, Jodie H K Man, Mieneke C M Luijendijk, Johannes W de Jong, Geoffrey van der Plasse, Louk J M J Vanderschuren, Roger A H Adan
Motivational deficits are a key symptom in multiple psychiatric disorders, including major depressive disorder, schizophrenia and addiction. A likely neural substrate for these motivational deficits is the brain dopamine (DA) system. In particular, DA signalling in the nucleus accumbens, which originates from DA neurons in the ventral tegmental area (VTA), has been identified as a crucial substrate for effort-related and activational aspects of motivation. Unravelling how VTA DA neuronal activity relates to motivational behaviours is required to understand how motivational deficits in psychiatry can be specifically targeted...
November 16, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29141189/role-of-cyclooxygenase-inhibitors-in-diminution-of-dissimilar-stress-induced-depressive-behavior-and-memory-impairment-in-rats
#5
Tahira Perveen, Shaista Emad, Saida Haider, Sana Sadaf, Sara Qadeer, Zehra Batool, Yousra Sarfaraz, Sheeza Sheikh
Memory functions can be considerably affected by various life events and stress has shown to be a chief regulator. Different stress patterns have distinct effects on the overall functioning of the brain. Stress provokes inflammation not only in the periphery but also in the brain. Neuroinflammation causes alterations in neuronal structure and function, which eventually progress to the development of neurodegenerative diseases. Inflammatory reactions are modulated through communication between the nervous, endocrine and immune systems...
November 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/29128806/emotional-disorders-induced-by-hemopressin-and-rvd-hemopressin-%C3%AE-administration-in-rats
#6
Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Sara Martinotti, Claudio Ferrante, Adriano Mollica, Giorgia Macedonio, Azzurra Stefanucci, Szabolcs Dvorácskó, Csaba Tömböly, Luciano De Petrocellis, Michele Vacca, Luigi Brunetti, Giustino Orlando
BACKGROUND: The endocannabinoid (eCB) system plays an important role in regulating emotional disorders, and is involved, directly or indirectly, in psychiatric diseases, such as anxiety and depression. Hemopressin, a hemoglobin α chain-derived peptide, and RVD-hemopressin(α), a N-terminally extended form of hemopressin, act as antagonist/inverse agonist and negative allosteric modulator of the cannabinoid 1 (CB1) receptor, respectively. METHODS: Considering the possible involvement of these peptides on emotional behaviour, the aim of our study was to investigate the behavioural effects of a single intraperitoneal (ip) injection of hemopressin (0...
June 23, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29125056/monosodium-glutamate-and-treadmill-exercise-anxiety-like-behavior-and-spreading-depression-features-in-young-adult-rats
#7
Suênia Marcele Vitor-de-Lima, Larissa de Brito Medeiros, Regina de Deus Lira Benevides, Catarina Nicácio Dos Santos, Nahara Oliveira Lima da Silva, Rubem Carlos Araújo Guedes
OBJECTIVES: The route of administration is an important factor in determining the action of some drugs. We previously demonstrated that subcutaneous monosodium glutamate (MSG) accelerated cortical spreading depression (CSD) in the rat and that treadmill exercise attenuated this effect. This study evaluated whether other routes of administration exert the same action by testing orogastric (gavage) and topical cortical MSG administration in treadmill-exercised and sedentary rats. Additionally, in the orogastric treatment we tested anxiety-like behavior...
November 10, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29107702/intra-nasal-dopamine-alleviates-cognitive-deficits-in-tgdisc1-rats-which-overexpress-the-human-disc1-gene
#8
An-Li Wang, Benedetta Fazari, Owen Y Chao, Susanne Nikolaus, Svenja V Trossbach, Carsten Korth, Fernando J Sialana, Gert Lubec, Joseph P Huston, Claudia Mattern, Maria Angelica de Souza Silva
The Disrupted-in-Schizophrenia 1 (DISC1) gene has been associated with mental illnesses such as major depression and schizophrenia. The transgenic DISC1 (tgDISC1) rat, which overexpresses the human DISC1 gene, is known to exhibit deficient dopamine (DA) homeostasis. To ascertain whether the DISC1 gene also impacts cognitive functions, 14-15 months old male tgDISC1 rats and wild-type controls were subjected to the novel object preference (NOP) test and the object-based attention test (OBAT) in order to assess short-term memory (1 h), long-term memory (24 h), and attention...
October 28, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29054014/sex-differences-in-behavioral-and-neurochemical-effects-of-gonadectomy-and-aromatase-inhibition-in-rats
#9
N Kokras, N Pastromas, D Papasava, C de Bournonville, C A Cornil, C Dalla
Aromatase inhibitors, which are widely used for the treatment of estrogen-dependent cancers, have been associated with psychiatric side effects ranging from mania to depression. In the present study, we investigated sex differences in the behavioral and neurochemical effects of aromatase inhibition on male and female, sham-operated or gonadectomized adult rats. Three weeks after surgery, rats received chronic treatment with the aromatase inhibitor letrozole or vehicle and were then subjected to the open field test, which assesses general activity...
October 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28985964/the-hemoglobin-derived-peptide-lvv-hemorphin-7-evokes-behavioral-effects-mediated-by-oxytocin-receptors
#10
Kellen Rosa da Cruz, Larissa Córdova Turones, Gabriel Camargo-Silva, Karina Pereira Gomes, Michelle Mendanha Mendonça, Pablinny Galdino, Christielly Rodrigues-Silva, Robson Augusto Souza Santos, Elson Alves Costa, Paulo Cesar Ghedini, Danielle Ianzer, Carlos Henrique Xavier
LVV-hemorphin-7 (LVV-h7) is bioactive peptide resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which displays oxytocinase activity. Herein, our aims were to assess whether: i) LVV-h7 modifies centrally organized behavior and cardiovascular responses to stress and ii) mechanisms underlying LVV-h7 effects involve activation of oxytocin (OT) receptors, probably as result of reduction of IRAP proteolytic activity upon OT...
September 28, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28948556/effects-of-fluorencarbonic-acid-derivative-on-the-levels-of-monoamines-and-their-metabolites-in-brain-structures-of-rats-with-modeled-depression-like-state
#11
L K Khnychenko, E E Yakovleva, E R Bychkov, P D Shabanov
The effects of the new structural analogue of benactyzine, a derivative of fluorencarbonic acid, on monoamine levels in brain structures were studied in male Wistar rats with experimental depression. Depressive state in rats was modeled by single injection of reserpine (4 mg/kg). The concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and their metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanilic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamus and striatum were measured by HPLC...
September 26, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28948423/repetitive-transcranial-magnetic-stimulation-inhibits-sirt1-mao-a-signaling-in-the-prefrontal-cortex-in-a-rat-model-of-depression-and-cortex-derived-astrocytes
#12
Zheng-Wu Peng, Fen Xue, Cui-Hong Zhou, Rui-Guo Zhang, Ying Wang, Ling Liu, Han-Fei Sang, Hua-Ning Wang, Qing-Rong Tan
Repetitive transcranial magnetic stimulation (rTMS) is a useful monotherapy for depression or adjunctive therapy for resistant depression. However, the anti-depressive effects of different parameters and the underlying mechanisms remain unclear. Here, we aimed to assess the effect of rTMS with different parameters (1/5/10 Hz, 0.84/1.26 T) on the depressive-like behaviors, 5-hydroxytryptamine (5-HT), 5-HIAA (5-hydroxyindoleacetic acid) and DA and NE levels, and monoamine oxidase A (MAO-A) activity in chronic unpredictable stress-treated rats, along with the expression of sirtuin 1 (Sirt1) and MAO-A in the prefrontal cortex (PFC) and cortex-derived astrocytes from new-born rats...
September 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28918253/deep-brain-stimulation-of-the-medial-forebrain-bundle-elevates-striatal-dopamine-concentration-without-affecting-spontaneous-or-reward-induced-phasic-release
#13
Marianne Klanker, Matthijs Feenstra, Ingo Willuhn, Damiaan Denys
Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) induces rapid improvement of depressive symptoms in patients suffering from treatment-refractory major depressive disorder (MDD). It has been hypothesized that activation of the dopamine (DA) system contributes to this effect. To investigate whether DBS in the MFB affects DA release in the striatum, we combined DBS with fast-scan cyclic voltammetry (FSCV) in freely moving rats. Animals were implanted with a stimulating electrode at the border of the MFB and the ventral tegmental area, and a FSCV microelectrode in the ventromedial striatum to monitor extracellular DA during the acute onset of DBS and subsequent continued stimulation...
November 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28887183/electrical-stimulation-of-the-hippocampal-fimbria-facilitates-neuronal-nitric-oxide-synthase-activity-in-the-medial-shell-of-the-rat-nucleus-accumbens-modulation-by-dopamine-d1-and-d2-receptor-activation
#14
Kristina E Hoque, Shannon R Blume, Stephen Sammut, Anthony R West
The medial shell region of the nucleus accumbens (msNAc) is a key center for the regulation of goal-directed behavior and is likely to be dysfunctional in neuropsychiatric disorders such as addiction, depression and schizophrenia. Nitric oxide (NO)-producing interneurons in the msNAc are potently modulated by dopamine (DA) and may play an important role in synaptic integration in msNAc networks. In this study, neuronal NO synthase (nNOS) activity was measured in anesthetized rats using amperometric microsensors implanted into the msNAc or via histochemical techniques...
November 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28843848/depressive-like-neurochemical-and-behavioral-markers-of-parkinson-s-disease-after-6-ohda-administered-unilaterally-to-the-rat-medial-forebrain-bundle
#15
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Anna Czarnecka, Elżbieta Lorenc-Koci
BACKGROUND: Although Parkinson's disease (PD) is characterized by progressive neurodegeneration of multiple neurotransmitter systems, 6-hydroxydopamine (6-OHDA) as a model substance is mainly used to selectively damage the nigrostriatal dopaminergic neurons and induce parkinsonian-like motor disturbances in rats. We hypothesized that high doses of this neurotoxin affecting other monoaminergic systems may also evoke the depressive-like behavior. METHODS: The impact of 6-OHDA (8, 12, 16μg/4μl) administered unilaterally into the medial forebrain bundle on the sucrose solution intake (a measure of anhedonia) and on the tissue levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the striatum (STR), substantia nigra (SN), prefrontal cortex (PFC) and hippocampus (HIP) was examined in rats pretreated or non-pretreated with desipramine...
June 3, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28764937/distinctive-changes-of-l-type-calcium-channels-and-dopamine-receptors-in-the-dorsomedial-and-dorsolateral-striatum-after-the-expression-of-habitual-cocaine-seeking-behavior-in-rats
#16
Fang Shen, Shubo Jin, Ying Duan, Jing Liang, Meng Zhang, Fengze Jiang, Nan Sui
Habitual drug-seeking behavior is essential in the transition from recreational drug use to compulsive drug use and is regulated by the dopamine (DA) system of the dorsal striatum (DS). However, a comparative study of the two subtypes of DA receptors, D1 receptors (D1R) and D2 receptors (D2R), which have opposite regulatory functions, in habitual drug-seeking behavior is absent. Moreover, the effects of L-type calcium channels (LTCCs) and the subtypes Cav1.2 and Cav1.3, which are downstream of D1R and D2R, respectively, on habitual drug-seeking behavior have yet to be revealed...
July 29, 2017: Neuroscience
https://www.readbyqxmd.com/read/28713283/excitatory-modulation-of-the-preb%C3%A3-tzinger-complex-inspiratory-rhythm-generating-network-by-endogenous-hydrogen-sulfide
#17
Glauber S F da Silva, João P J Sabino, Vishaal Rajani, Tucaauê S Alvares, Silvia Pagliardini, Luiz G S Branco, Gregory D Funk
Hydrogen Sulfide (H2S) is one of three gasotransmitters that modulate excitability in the CNS. Global application of H2S donors or inhibitors of H2S synthesis to the respiratory network has suggested that inspiratory rhythm is modulated by exogenous and endogenous H2S. However, effects have been variable, which may reflect that the RTN/pFRG (retrotrapezoid nucleus, parafacial respiratory group) and the preBötzinger Complex (preBötC, critical for inspiratory rhythm generation) are differentially modulated by exogenous H2S...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28711395/silymarin-ameliorates-experimentally-induced-depressive-like-behavior-in-rats-involvement-of-hippocampal-bdnf-signaling-inflammatory-cytokines-and-oxidative-stress-response
#18
Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Patel
Silymarin is a polyphenolic flavonoid of Silybum marianum, exhibited neuroprotection and antidepressant like activity in acute restraint stressed mice. The main objective of the present study is to investigate possible antidepressant like activity of silymarin in experimentally induced depressive behavior in rats. The depressive behaviors were induced in rats by olfactory bulbectomized (OBX) technique. Wistar rats were administered with silymarin at a dose of 100mg/kg and 200mg/kg, by per oral in OBX and sham operated rats...
July 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28694833/huanglian-jie-du-tang-extract-ameliorates-depression-like-behaviors-through-bdnf-trkb-creb-pathway-in-rats-with-chronic-unpredictable-stress
#19
Yi-Lu Ye, Kai Zhong, Dan-Dan Liu, Jing Xu, Bei-Bei Pan, Xiang Li, Yue-Ping Yu, Qi Zhang
Neuroinflammation is considered as one of the common pathogeneses of depression. Huanglian-Jie-Du-Tang (HJDT) is a traditional Chinese herbal formula. The present study investigates the antidepressant-like effect of HJDT and its possible mechanism in rats. Rats were given HJDT (2, 4, and 8 g/kg, intragastrically), paroxetine (1.8 mg/kg, intragastrically), or an equivalent volume of saline for 42 days. The depression-related behaviors, including sucrose preference test (SPT), open field test (OFT), novel objective recognition task (NORT), and forced swimming test (FST), were detected...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28662375/the-impact-of-chronic-mild-stress-on-long-term-depressive-behavior-in-rats-which-have-survived-sepsis
#20
Amanda V Steckert, Diogo Dominguini, Monique Michels, Helena M Abelaira, Débora B Tomaz, Beatriz Sonai, Airam B de Moura, Danyela Matos, Júlia B I da Silva, Gislaine Z Réus, Tatiana Barichello, João Quevedo, Felipe Dal-Pizzol
The present study was created to investigate the effects of chronic mild stress (CMS) on the depressive behavior and neurochemical parameters of rats that were subjected to sepsis. Wistar rats were subjected to a CMS protocol, and sepsis was induced by cecal ligation and perforation (CLP). The animals were then divided into 4 separate groups; Control + Sham (n = 20), Control + CLP (n = 30), CMS + Sham (n = 20) and CMS + CLP (n = 30). Body weight, food and water intake and mortality were measured on a daily basis for a period of 10 days after the induction of sepsis...
June 16, 2017: Journal of Psychiatric Research
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