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Helicobacter eradication

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https://www.readbyqxmd.com/read/28098408/vonoprazan-improves-the-efficacy-of-helicobacter-pylori-eradication-therapy-with-a-regimen-consisting-of-clarithromycin-and-metronidazole-in-patients-allergic-to-penicillin
#1
Shoko Ono, Mototsugu Kato, Soichi Nakagawa, Katsuhiro Mabe, Naoya Sakamoto
BACKGROUND: Although all Helicobacter pylori (H. pylori)-positive patients should receive eradication therapy, the therapy is a challenge for patients allergic to penicillin. There have been a few reports on the efficacy of eradication therapy for such patients. OBJECTIVE: To analyze the efficacy of vonoprazan or proton pump inhibitor (PPI)-based 7-day triple therapy in patients allergic to penicillin. MATERIALS AND METHODS: A total of 88 consecutive patients allergic to penicillin who received H...
January 18, 2017: Helicobacter
https://www.readbyqxmd.com/read/28095729/impact-of-reactive-oxygen-species-generation-on-helicobacter-pylori-related-extragastric-diseases-a-hypothesis
#2
Jannis Kountouras, Marina Boziki, Stergios A Polyzos, Panagiotis Katsinelos, Emmanouel Gavalas, Christos Zeglinas, Dimitri Tzivras, Iordanis Romiopoulos, Nikolaos Giorgakis, Kyriaki Anastasiadou, Elizabeth Vardaka, Constantinos Kountouras, Evangelos Kazakos, Georgia Xiromerisiou, Efthimios Dardiotis, Georgia Deretzi
Helicobacter pylori (H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety of H. pylori-related gastric diseases, as shown in animal and human studies. Helicobacter pylori infection is also associated with variety of systemic extragastric diseases in which H. pylori-related ROS production might also be involved in the pathogenesis of these systemic conditions. We proposed that Hp-related ROS may play a crucial role in the pathophysiology of Hp-related systemic diseases including Alzheimer's disease, multiple sclerosis, glaucoma and other relative neurodegenerative diseases, thereby suggesting introduction of relative ROS scavengers as therapeutic strategies against these diseases which are among the leading causes of disability and are associated with a large public health global burden...
January 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28091405/evaluation-of-helicobacter-pylori-infection-in-patients-with-chronic-hepatic-disease
#3
Ju Huang, Jun Cui
BACKGROUND: The 13C urea breath test (13C-UBT) is the gold standard for detecting Helicobacter pylori infection. H. pylori pathogenesis in patients with hepatitis B virus (HBV) and related diseases remains obscure. We used 13C-UBT to detect H. pylori infection in patients with chronic HBV infection, HBV-related cirrhosis, HBV-related hepatic carcinoma, and other chronic hepatic diseases. METHODS: A total of 131 patients with chronic hepatitis B (HB), 179 with HBV-related cirrhosis, 103 with HBV-related hepatic carcinoma, 45 with HBV-negative hepatic carcinoma, and 150 controls were tested for H...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28087975/screening-and-treating-helicobacter-pylori-infection-for-gastric-cancer-prevention-on-the-population-level
#4
REVIEW
Yi-Chia Lee, Jaw-Town Lin
Helicobacter pylori infection is the major cause of gastric cancer, and removal of H. pylori infection from a population could theoretically decrease the number of cases by about 89%. However, in real-life settings, few studies have reported the effect of screening and treating this pathogen in population-based programs. This is mainly because of the lack of an adequate infrastructure for delivery of systematic screening services to asymptomatic individuals, the lack of standardization to ensure that each subject receives the correct diagnostic testing and antibiotic treatment, and limited resources...
January 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28079669/the-irish-helicobacter-pylori-working-group-consensus-for-the-diagnosis-and-treatment-of-h-pylori-infection-in-adult-patients-in-ireland
#5
Sinead Smith, Breida Boyle, Denise Brennan, Martin Buckley, Paul Crotty, Maeve Doyle, Richard Farrell, Mary Hussey, David Kevans, Peter Malfertheiner, Francis Megraud, Sean Nugent, Anthony O'Connor, Colm O'Morain, Shiobhan Weston, Deirdre McNamara
BACKGROUND: Irish eradication rates for Helicobacter pylori are decreasing and there is an increase in the prevalence of antibiotic-resistant bacteria. These trends call into question current management strategies. OBJECTIVE: To establish an Irish Helicobacter pylori Working Group (IHPWG) to assess, revise and tailor current available recommendations. METHODS: Experts in the areas of gastroenterology and microbiology were invited to join the IHPWG...
January 10, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28079346/increasing-role-for-modified-bismuth-containing-quadruple-therapies-for-helicobacter-pylori-eradication
#6
David Y Graham, Sharmila Fagoonee, Rinaldo Pellicano
No abstract text is available yet for this article.
January 12, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28077338/10-day-bismuth-containing-quadruple-therapy-is-effective-as-first-line-therapy-for-helicobacter-pylori-related-chronic-gastritis-a-prospective-randomized-study-in-china
#7
Liangjing Wang, Zhenghua Lin, Shujie Chen, Jun Li, Chun Xiao Chen, Zhiming Huang, Bin Ye, Jin Ding, Wei Li, Lunpo Wu, Ying Jiang, Lina Meng, Qin Du, Jianmin Si
OBJECTIVES: To investigate the effectiveness of 10-day bismuth-containing quadruple (B-quadruple) treatment as first-line therapy in patients with Helicobacter pylori related chronic gastritis. METHODS: Randomized control trial conducted from Oct. 2011 to Dec. 2013 in Zhejiang, China, including patients with H. pylori-related chronic gastritis who were randomly given either 10-day omeprazole-based triple (OM-triple, omeprazole 20 mg twice daily, clarithromycin 500 mg twice daily and amoxicillin 1g twice daily), or 10-day B-quadruple therapy (OM-triple + bismuth subcitrate 120 mg four times daily)...
January 7, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28074932/the-helicobacter-cinaedi-antigen-caip-participates-in-atherosclerotic-inflammation-by-promoting-the-differentiation-of-macrophages-in-foam-cells
#8
Mario Milco D'Elios, Francesca Vallese, Nagaja Capitani, Marisa Benagiano, Maria Lina Bernardini, Mirko Rossi, Gian Paolo Rossi, Mauro Ferrari, Cosima Tatiana Baldari, Giuseppe Zanotti, Marina de Bernard, Gaia Codolo
Recent studies have shown that certain specific microbial infections participate in atherosclerosis by inducing inflammation and immune reactions, but how the pathogens implicated in this pathology trigger the host responses remains unknown. In this study we show that Helicobacter cinaedi (Hc) is a human pathogen linked to atherosclerosis development since at least 27% of sera from atherosclerotic patients specifically recognize a protein of the Hc proteome, that we named Cinaedi Atherosclerosis Inflammatory Protein (CAIP) (n = 71)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071063/acute-psychotic-episode-secondary-to-helicobacter-pylori-eradication-treatment
#9
Rubén Fernández Martos, Aurora Burgos García, Consuelo Froilán Torres
The side effects of Helicobacter pylori (H. pylori) eradication treatment are few, usually in the form of gastrointestinal or allergic complaints. However, occasionally, some antibiotics including clarithromycin, included in the classic eradication regimen, may result in reversible psychosis, a condition called "antibiomania" or "Hoigne syndrome".
January 10, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28066960/consensus-on-the-clinical-management-screening-to-treat-and-surveillance-of-helicobacter-pylori-infection-to-improve-gastric-cancer-control-on-a-nationwide-scale
#10
Bor-Shyang Sheu, Ming-Shiang Wu, Cheng-Tang Chiu, Jing-Chuan Lo, Deng-Chyang Wu, Jyh-Ming Liou, Chun-Ying Wu, Hsiu-Chi Cheng, Yi-Chia Lee, Ping-I Hsu, Chun-Chao Chang, Wei-Lun Chang, Jaw-Town Lin
BACKGROUND: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. MATERIALS AND METHODS: This consensus statement for management of H...
January 8, 2017: Helicobacter
https://www.readbyqxmd.com/read/28057446/long-term-follow-up-of-pepsinogen-i-ii-ratio-after-eradication-of-helicobacter-pylori-in-patients-who-underwent-endoscopic-mucosal-resection-for-gastric-cancer
#11
Su Youn Nam, Seong Woo Jeon, Hyun Seok Lee, Yong Hwan Kwon, Haeyoon Park, Jin Woo Choi
BACKGROUND: Although the pepsinogen I/II (PGI/II) ratio after Helicobacter pylori eradication is recovered at short-term follow-up, long-term follow-up studies of PGI/II are rare. METHODS: A total of 773 patients with gastric cancer who underwent endoscopic resection and pepsinogen and H. pylori tests were enrolled. H. pylori was eradicated in these patients. Endoscopic and pepsinogen tests were performed every year. A low PGI/II ratio was defined as ≤3. RESULTS: The PGI/II ratio was higher in non-infected patients (n=275, 4...
December 21, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28056333/-recommendation-for-the-prevention-and-treatment-of-non-steroidal-anti-inflammatory-drug-induced-gastrointestinal-ulcers-and-its-complications
#12
(no author information available yet)
Non-steroidal anti-inflammatory drugs (NSAIDs) are a broad class of non glucocorticoid drugs which are extensively used in anti-inflammatory, analgesic, and antipyretic therapies. However, NSAIDs may cause many side effects, most commonly in gastrointestinal(GI) tract. Cardiovascular system, kidney, liver, central nervous system and hematopoietic system are also involved. NSAID-induced GI side effects not only endanger the patients' health, increase mortality, but also greatly increase the cost of medical care...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28054994/synthesis-of-new-nitrofluoroquinolone-derivatives-with-novel-anti-microbial-properties-against-metronidazole-resistant-h-pylori
#13
Luay Abu-Qatouseh, Mohammad Abu-Sini, Amal Mayyas, Yusuf Al-Hiari, Rula Darwish, Talal Aburjai
One of the major therapeutic approaches to preventing relapse and accelerating the healing of duodenal and gastric ulcers is the eradication of Helicobacter pylori. Due to the emergence of antibiotic resistance among clinical strains of H. pylori, alternative approaches using newly discovered antimicrobial agents in combination with the standard regimens for the treatment of H. pylori are increasingly needed. The purpose of the present study was to investigate the effect of newly synthesized 8-nitroflouroqunolone derivatives when used either alone or when combined with metronidazole against metronidazole-resistant H...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28054971/the-development-of-urease-inhibitors-what-opportunities-exist-for-better-treatment-of-helicobacter-pylori-infection-in-children
#14
Sherif T S Hassan, Miroslava Šudomová
Stomach infection with Helicobacter pylori (H. pylori) causes severe gastroduodenal diseases in a large number of patients worldwide. The H. pylori infection breaks up in early childhood, persists lifelong if not treated, and is associated with chronic gastritis and an increased risk of peptic ulcers and gastric cancer. In recent years, the problem of drug-resistant strains has become a global concern that makes the treatment more complicated and the infection persistent at higher levels when the antibiotic treatment is stopped...
January 4, 2017: Children
https://www.readbyqxmd.com/read/28053856/a-primary-esophageal-malt-lymphoma-patient-with-helicobacter-pylori-infection-achieved-complete-remission-after-h-pylori-eradication-without-anti-lymphoma-treatment
#15
Keiichi Moriya, Hideto Tamura, Kyoko Nakamura, Masaru Hosone, Koiti Inokuchi
Primary esophageal lymphoma is an extremely rare disease. We report a 76-year-old woman with esophageal lymphoma who achieved remission after Helicobacter pylori (HP) eradication. Esophagogastroduodenoscopy (EGD) revealed a mass in the lower esophagus, and she was diagnosed with stage IE mucosa-associated lymphoid tissue (MALT) lymphoma. She rejected any anti-lymphoma treatment except for HP eradication. Follow-up EGD demonstrated the disappearance of the esophageal MALT lymphoma 2 months after HP eradication, and she remained in remission for more than 3 years...
2017: Leukemia Research Reports
https://www.readbyqxmd.com/read/28053340/population-screening-and-treatment-of-helicobacter-pylori-infection
#16
REVIEW
Anthony O'Connor, Colm A O'Morain, Alexander C Ford
Helicobacter pylori is an important human pathogen, associated with a substantial burden from both malignant and non-malignant diseases. The bacterium is classed as a human carcinogen, being strongly linked with gastric cancer, the third most common cause of cancer death worldwide and is also associated with common conditions such as dyspepsia and peptic ulcer. Eradication of H. pylori reduces the incidence of gastric cancer and peptic ulcer, as well as the prevalence and costs of managing dyspepsia. Economic analyses suggest that eradication of H...
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28049442/analyzing-the-influence-of-gastric-intestinal-metaplasia-on-gastric-ulcer-healing-in-helicobacter-pylori-infected-patients-without-atrophic-gastritis
#17
Li-Wei Chen, Liang-Che Chang, Chung-Ching Hua, Bor-Jen Hsieh, Shuo-Wei Chen, Rong-Nan Chien
BACKGROUND: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM. This study aimed to compare the difference in GU healing between H. pylori-infected patients with IM and those without IM. METHODS: We retrospectively analyzed patients at the Keelung Chung Gung Memorial Hospital during the period from March 2005 to January 2011...
January 3, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28030862/a-comparative-study-of-a-new-class-of-gastric-acid-suppressant-agent-named-vonoparazan-versus-esomeprazole-for-the-eradication-of-helicobacter-pylori
#18
Masahiro Tsujimae, Hiroshi Yamashita, Hiroki Hashimura, Chise Kano, Keiko Shimoyama, Atsushi Kanamori, Kei Matsumoto, Akio Koizumi, Kenji Momose, Takaaki Eguchi, Takumi Fukuchi, Mikio Fujita, Akihiko Okada
BACKGROUND: Helicobacter pylori eradication rates have decreased worldwide. Gastric acid inhibition during treatment is important to eradicate these bacteria successfully. A new potassium-competitive acid blocker, vonoprazan (VPZ), has been shown to achieve high eradication rates in a previous randomized controlled trial. OBJECTIVE: To determine the efficacy of VPZ for H. pylori eradication. METHODS: A total of 874 patients were enrolled; 431 received esomeprazole (EPZ) and 443 received VPZ...
2016: Digestion
https://www.readbyqxmd.com/read/28026906/recurrence-of-helicobacter-pylori-infection-and-the-affecting-factors-a-follow-up-study
#19
Li Ya Zhou, Zhi Qiang Song, Yan Xue, Xiao Li, Yan Qing Li, Jia Ming Qian
OBJECTIVE: Recurrence of Helicobacter pylori (H. pylori) infection weakens the protective effect and long-term prognosis of eradication. With the widespread therapies, decreasing prevalence of H. pylori infection and improvement in living conditions, the recurrence of H. pylori infection may present with new features. This study aimed to determine the recurrence rate of H. pylori infection and its affecting factors in a prospective, large-sample-sized, multicenter follow-up study. METHODS: A total of 827 patients receiving successful H...
December 27, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28025702/characteristics-of-gastric-cancer-in-negative-test-of-serum-anti-helicobacter-pylori-antibody-and-pepsinogen-test-a-multicenter-study
#20
Mariko Kiso, Masaharu Yoshihara, Masanori Ito, Kazuhiko Inoue, Katsuaki Kato, Shigemi Nakajima, Katsuhiro Mabe, Masao Kobayashi, Naomi Uemura, Tomoyuki Yada, Masashi Oka, Takashi Kawai, Tomoyuki Boda, Takahiro Kotachi, Kazuhiko Masuda, Shinji Tanaka, Kazuaki Chayama
BACKGROUND AND AIM: The serological risk prediction system combines the pepsinogen test and anti-Helicobacter pylori (H. pylori) antibody determination. In this system, chronic atrophic gastritis (CAG) is diagnosed using the pepsinogen test. Patients who are H. pylori negative and pepsinogen negative are classified into group A, are assumed to be H. pylori uninfected, and are at an extremely low risk for gastric cancer. However, gastric cancers are detected in this group. The aim of this study is to clarify the clinicopathological status of group A patients with gastric cancer...
December 26, 2016: Gastric Cancer
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