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https://www.readbyqxmd.com/read/29775875/the-reduced-level-of-growth-factors-in-an-animal-model-of-depression-is-accompanied-by-regulated-necrosis-in-the-frontal-cortex-but-not-in-the-hippocampus
#1
Mateusz Kucharczyk, Anna Kurek, Bartosz Pomierny, Jan Detka, Mariusz Papp, Katarzyna Tota, Bogusława Budziszewska
In the present study, we asked if the different types of stress alter neuronal plasticity markers distinctively in the frontal cortex (FCx) and in the hippocampus (Hp). To do so, we implemented various stress regimens to analyze changes evoked in these rat brain structures. We utilized several molecular techniques, including western blot, ELISA, quantitative RT-PCR, and various biochemical assays, to examine a range of proteins and subjected rats to behavioral tests to evaluate potential maladaptive alterations...
May 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775222/abca1-inhibits-pdgf-induced-proliferation-and-migration-of-rat-airway-smooth-muscle-cell-through-blocking-tlr2-nf-%C3%AE%C2%BAb-nfatc1-signaling
#2
Wei Cheng, Kun Yan, Yanni Chen, Wen Zhang, Zongzheng Ji, Chengxue Dang
Airway remodeling is a key feature of asthma, characterized by abnormal proliferation and migration of airway smooth muscle cells (ASMCs). ABCA1, a member of the ATP-binding cassette family of active transporters, plays an essential role in the progression of lung diseases. However, the contributions of ABCA1 in ASMCs remain to be explored. The purpose of the present study was to investigate the functional role and potential molecular mechanism of ABCA1 in platelet derived growth factor (PDGF)-induced primary rat ASMC proliferation and migration...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29774748/assessment-of-trazodone-induced-cardiotoxicity-after-repeated-doses-in-rats
#3
O Atli, V Kilic, M Baysal, G Kilic, G Gormus, S Ucarcan, B Korkut, S Ilgin
Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting results were observed in these studies. Therefore, we aimed to investigate the cardiac adverse effects of TRZ in rats at repeated doses in our study. In accordance with this purpose, TRZ was administered orally to rats at 5, 10, and 20 mg/kg doses for 28 days. Electrocardiogram records, serum aspartate aminotransferase (AST), lactate dehydrogenase, creatine kinase-myoglobin band, cardiac troponin-T (cTn-T) levels, DNA damage in cardiomyocytes, and histologic view of heart tissues were evaluated...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29773910/the-l-type-calcium-channel-blocker-isradipine-attenuates-cue-induced-cocaine-seeking-by-enhancing-dopaminergic-activity-in-the-ventral-tegmental-area-to-nucleus-accumbens-pathway
#4
Nii A Addy, Eric J Nunes, Shannon M Hughley, Keri M Small, Sarah J Baracz, Joshua L Haight, Anjali M Rajadhyaksha
Previous preclinical and clinical investigations have focused on the L-type calcium channel (LTCC) as a potential therapeutic target for substance abuse. While some clinical studies have examined the ability of LTCC blockers to alter cocaine's subjective effects, very few LTCC studies have examined cocaine relapse. Here, we examined whether ventral tegmental area (VTA)-specific or systemic administration of the LTCC inhibitor, isradipine, altered cocaine-seeking behavior in a rat model. Male Sprague-Dawley rats first received 10 days of cocaine self-administration training (2 h sessions), where active lever depression resulted in delivery of a ∼0...
May 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29772867/-depressant-effect-of-lithium-on-apoptosis-of-nerve-cells-of-adult-rats-after-spinal-cord-injury
#5
Fang Wang, Chao Zhou, Zheng-Chao Gao, Yu-Huan Li, Wen-Long Yang, Dong Wang, Hao-Peng Li, Xi-Jing He
OBJECTIVE: To study whether lithium agent produces neuroprotective effect by inhibiting the nerve cell apoptosis of rats after spinal cord injury. METHODS: Forty-two male SD rats weighing 200 to 250 g were randomly divided into 3 groups: blank control group( n =6) without surgery, normal saline(NS) group( n =18) with intraperitoneal injection of NS (40 mg/kg); and Lithium chloride (Licl) group ( n =18) with intraperitoneal injection of Licl (40 mg/kg). After Allen method modeling, Licl group started intraperitoneal injection of Licl solution (40 mg·kg⁻¹·d⁻¹) within 15 min after operation to the second week...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772537/maternal-deprivation-promotes-hippocampal-neuronal-apoptosis-via-erk1-2-signaling
#6
Min Chen, Guoping He, Qiang Li
Neonatal maternal deprivation (MD) leads to depressive-like behaviors by promoting hippocampal neuronal apoptosis, but whether and how ERK1/2 signaling participates in MD-induced hippocampal neuronal apoptosis remains unclear. We therefore explored the role of ERK1/2 signaling pathway in neonatal MD-induced depression. Neonatal rats were divided into control group, PD group given intraperitoneal injections of MAPKK inhibitor (PD98059), MD group, and MD+PD group. The neonatal MD model was confirmed by behavioral tests...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29772083/effects-of-prenatal-stress-on-anxiety-and-depressive-like-behaviors-are-sex-specific-in-prepubertal-rats
#7
Ann Mary Iturra-Mena, Marcia Arriagada-Solimano, Ariane Luttecke-Anders, Alexies Dagnino-Subiabre
The fetal brain is highly susceptible to stress in late pregnancy, with lifelong effects of stress on physiology and behavior. The aim of this study was to determine the physiological and behavioral effects of prenatal stress during the prepubertal period of female and male rats. We subjected pregnant Sprague-Dawley rats to a restraint stress protocol from gestational day 14 until 21, a critical period for fetal brain susceptibility to stress effects. Male and female offspring were subsequently assessed at postnatal day 24 for anxiety- and depressive-like behaviors, and spontaneous social interaction...
May 17, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29770521/nicotine-mediated-neuroprotection-of-rat-spinal-networks-against-excitotoxicity
#8
Jaspreet Kaur, Rossana Rauti, Andrea Nistri
Activation of neuronal nicotinic acetylcholine receptors (nAChRs) by nicotine is reported to protect brain neurons from glutamate excitotoxicity. We inquired whether a similar phenomenon can occur in the rat isolated spinal cord (or spinal slice culture) challenged by a transient (1 h) application of kainate (a powerful glutamate receptor agonist) to induce excitotoxicity mimicking spinal injury in vitro. We recorded spinal reflexes and fictive locomotion generated by the locomotor central pattern generator before and 24 h after applying kainate...
May 16, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29769654/morphological-and-functional-changes-in-the-rat-retina-associated-with-2-months-of-intermittent-moderate-intraocular-pressure-elevation
#9
Bingyao Tan, Akshay Gurdita, Vivian Choh, Karen M Joos, Ratna Prasad, Kostadinka Bizheva
Morphological and functional changes in the rat retina and optic nerve head (ONH), associated with 8 weeks of intermittent moderately elevated intraocular pressure (IOP) were measured with a combined ultrahigh resolution optical coherence tomography (UHR-OCT) and electroretinography (ERG) system. The IOP of male Sprague-Dawley rats was raised in one eye to ~35 mmHg for 1 hour/day on 6 days each week using vascular loops. Single-flash ERG traces and volumetric UHR-OCT images of the ONH were acquired from both eyes before, during and after IOP elevations at weeks 1, 5 and 9 of the study...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768248/bisphenol-a-decreases-the-spontaneous-contractions-of-rat-uterus-in-vitro-through-a-nitrergic-mechanism
#10
Hemlata Gupta, Shripad B Deshpande
BACKGROUND: Bisphenol A (BPA), a chemical used in the manufacture of plastics, has toxic effects on various systems of the human body including the reproductive system. BPA possesses estrogenic activity and is implicated in altering oogenesis, ovulation, and fertility. In addition to ovulatory changes, uterine contractility is an important factor for fertility. However, the effects of BPA on myometrial contractions are not known. Therefore, we examined the effect of BPA on rat uterine contractions...
May 16, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29766828/protective-effects-of-crocetin-on-depression-like-behavior-induced-by-immobilization-in-rat
#11
Tahereh Farkhondeh, Saeed Samarghandian, Fariborz Samini, Ali Rajabpour Sanati
Crocetin, an active ingredient of saffron, has been recognized as a potent antioxidant. Plant extracts or their components may be useful in ameliorating the various diseases, including neurodegenerative disorders. This study investigated the effects of crocetin on oxidative damage induced by chronic restraint stress in the rat brain. For this reason, rats were kept in the restrainers for 1 hour every day, for 21 consecutive days. The animals were injected of crocetin (20, 40, 60 mg/kg) or vehicle daily for 21 days...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29764242/morbidity-and-mortality-resulting-from-acute-inhalation-exposures-to-hydrogen-fluoride-and-carbonyl-fluoride-in-rats
#12
Adolph J Januszkiewicz, Matthew A Bazar, Lee C B Crouse, Michael A Chapman, Steven E Hodges, Steven J McCormick, Arthur J O'Neill
OBJECTIVE: Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF2 ). METHODS: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF2 . Respiration was monitored before, during, and after exposure. Animals were observed up to 6 days post-exposure. Terminal blood samples were collected for routine clinical chemistry and hematology...
May 15, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29761007/behavioral-changes-induced-through-adenosine-a2a-receptor-ligands-in-a-rat-depression-model-induced-by-olfactory-bulbectomy
#13
Karla Margarita Padilla, Andres Quintanar-Setephano, Fabian López-Vallejo, Laura Cristina Berumen, Ricardo Miledi, Guadalupe García-Alcocer
Background: Major depressive disorders are characterized by their severity and long-lasting symptoms, which make such disorders highly disabling illnesses. Unfortunately, 50% of major depressive patients experience relapses, perhaps partly because drug research has been performed only in animal models that screen for antidepressant drugs that appear to only ameliorate acute depression symptoms. The bilateral olfactory bulbectomy (OBX) animal model presents the advantage of mimicking the symptoms of chronic depression by means of brain surgery...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29759136/characterization-of-sleep-pattern-and-neuro-immune-endocrine-markers-at-24-hour-post-injection-of-a-single-low-dose-of-lipopolysaccharide-in-male-wistar-rats
#14
Francisco Nachón-García, Gabriela Hurtado-Alvarado, Mario E Acosta-Hernández, Carolina Peña-Escudero, Sergio Priego-Fernández, Samantha Alvarez-Herrera, Enrique Becerril-Villanueva, Gilberto Pérez-Sánchez, Lenin Pavón, Fabio García-García
The long-term effect of immune system activation by a low dose of lipopolysaccharide on neuro-immune-endocrine regulation is unclear. Sleep, neurotransmitter concentrations, TNF-α, and corticosterone levels were evaluated in male Wistar rats implanted with conventional sleep recordings. In this work, we found that REM sleep was reduced in the first 4 h post-injection, without affecting the total sleep time, while adrenaline concentration was reduced in the hippocampus at 24 h post-injection of LPS. Our results demonstrated that, although the acute immune response was not evident 24 h after the injection of LPS, it was able to promote the reduction of AD in the hippocampus, which may explain in part the depressive behavior reported in rodents following LPS administration...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29758248/beneficial-effect-of-etazolate-on-depression-like-behavior-and-learning-and-memory-impairment-in-a-model-of-parkinson-s-disease
#15
Karem H Alzoubi, Enas Mokhemer, Amjad N Abuirmeileh
The aim of this study was to evaluate etazolate against depression-like behavior and, learning and memory impairment induced by 6- hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD). This aim was achieved through comparing 6-OHDA lesioned rats in the presence and absence of etazolate. The 6-OHDA was used to induce lesion as a model of PD. Etazolate was administered at a dose of 1 mg/kg/day for 14 days, starting 7 days after lesion induction. Apomorphine-induced rotation test was used to evaluate 6-OHDA-induced motor deficits, tail suspension test was used to assess depression-like symptoms, and the radial arms water maze (RAWM) was used to evaluate special learning and memory functions...
May 11, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29757463/depression-related-behavioural-and-neuroendocrine-changes-in-the-spontaneously-diabetic-torii-sdt-fatty-rat-an-animal-model-of-type-2-diabetes-mellitus
#16
Katsuya Sakimura, Tatsuya Maekawa, Kazuo Sasagawa, Yukihito Ishii, Shin-Ichi Kume, Takeshi Ohta
Depression is one of the most common psychiatric diseases and is commonly comorbid with type 1 or 2 diabetes mellitus (DM). However, the pathophysiology underlying the depressive state in DM remains poorly understood. Animal models are useful tools to investigate the association between depression and DM. In the present study we investigated whether the Spontaneously Diabetic Torii (SDT) fatty rat, a novel animal model of type 2 DM, shows depression-related features. We assessed depression-like behaviour, hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and neurotransmitter levels in the brain...
May 14, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29756530/the-occurrence-of-spontaneous-cortical-spreading-depression-is-increased-by-blood-constituents-and-impairs-neurological-recovery-after-subdural-hematoma-in-rats
#17
Harald Krenzlin, Daniel Jussen, Michaela Maria Plath, Stephan Tretzel, Tobias Kraemer, Oliver Kempski, Beat Alessandri
Acute subdural haemorrhage (ASDH) is common and associated with severe morbidity and mortality. To date, the role of spontaneous cortical spreading depression (sCSD) in exaggerating secondary injury after ASDH, is poorly understood. The present study contains two experimental groups: First, we investigated and characterized the occurrence of sCSD after subdural blood infusion (300 µl) via tissue impedance (IMP) measurement in a rat model. Second, we compared the occurrence and influence of sCSD on lesion growth and neurological deficit in the presence and absence of whole blood constituents...
May 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29755030/detrimental-effect-of-hypericum-perforatum-on-ovarian-functions
#18
Buket Demirci, Fadime Kahyaoğlu, Tolga Atakul, Mustafa Yılmaz, Yavuz Özoran
OBJECTIVE: Hypericum perforatum (HP) is widely used for depression and distress treatment as an over-the-counter plant in any age. This study investigated the safety of HP on ovarian functions and infertility. MATERIAL AND METHODS: HP given to the rats in two different doses (100 and 300 mg/kg/day) with drinking water for four weeks. Half of the treatment groups have been sacrificed at the end of four weeks intervention, remained have been sacrificed after additional waiting period for four weeks to see reversibility if there is...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29753752/the-cingulum-bundle-anatomy-function-and-dysfunction
#19
REVIEW
Emma J Bubb, Claudia Metzler-Baddeley, John P Aggleton
The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its apparent continuity, the cingulum's composition continually changes as fibres join and leave the bundle. To help understand its complex structure, this review begins with detailed, comparative descriptions of the multiple connections comprising the cingulum bundle. Next, the impact of cingulum bundle damage in rats, monkeys, and humans is analysed...
May 10, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29752492/novel-antidepressant-effects-of-paeonol-alleviate-neuronal-injury-with-concomitant-alterations-in-bdnf-rac1-and-rhoa-levels-in-chronic-unpredictable-mild-stress-rats
#20
Xiu-Ling Zhu, Jing-Jing Chen, Fei Han, Chuan Pan, Ting-Ting Zhuang, Ya-Fei Cai, Ya-Ping Lu
RATIONALE: Increasing evidence has suggested that major depressive disorder (MDD) is highly associated with brain-derived neurotrophic factor (BDNF) levels, dendrites atrophy, and loss of dendritic spines, especially in emotion-associated brain regions including the hippocampus. Paeonol is a kind of polyphenols natural product with a variety of therapeutic effects. Recent studies have reported its antidepressant effects. However, it is unclear what signaling pathways contribute to improve MDD...
May 12, 2018: Psychopharmacology
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